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Journal articles on the topic 'Optoretinography'

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Author: Grafiati

Published: 10 December 2022

Last updated: 28 January 2023

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1

Cooper, Robert F., David H. Brainard, and Jessica I. W. Morgan. "Optoretinography of individual human cone photoreceptors." Optics Express 28, no. 26 (December 14, 2020): 39326. http://dx.doi.org/10.1364/oe.409193.

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2

Yao, Xincheng, and Tae-Hoon Kim. "Fast intrinsic optical signal correlates with activation phase of phototransduction in retinal photoreceptors." Experimental Biology and Medicine 245, no. 13 (June 19, 2020): 1087–95. http://dx.doi.org/10.1177/1535370220935406.

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Quantitative assessment of physiological condition of retinal photoreceptors is desirable for better detection and treatment evaluation of eye diseases that can cause photoreceptor dysfunctions. Functional intrinsic optical signal (IOS) imaging, also termed as optoretinography (ORG) or optophysiology, has been proposed as a high-resolution method for objective assessment of retinal physiology. Fast IOS in retinal photoreceptors shows a time course earlier than that of electroretinography a-wave, promising an objective marker for noninvasive ORG of early phototransduction process in retinal photoreceptors. In this article, recent observations of fast photoreceptor-IOS in animal and human retinas are summarized, and the correlation of fast photoreceptor-IOS to five steps of phototransduction process is discussed. Transient outer segment conformational change, due to inter-disc space shrinkage correlated with activation phase of phototransduction, has been disclosed as a primary source of the fast photoreceptor-IOS. Impact statement As the center of phototransduction, retinal photoreceptors are responsible for capturing and converting photon energy to bioelectric signals for following visual information processing in the retina. This article summarizes experimental observation and discusses biophysical mechanism of fast photoreceptor-intrinsic optical signal (IOS) correlated with early phase of phototransduction. Quantitative imaging of fast photoreceptor-IOS may provide objective optoretinography to advance the study and diagnosis of age-related macular degeneration, retinitis pigmentosa, diabetic retinopathy, and other eye diseases that can cause photoreceptor dysfunctions.

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3

Pandiyan, Vimal Prabhu, Xiaoyun Jiang, Aiden Maloney-Bertelli, James A. Kuchenbecker, Utkarsh Sharma, and Ramkumar Sabesan. "High-speed adaptive optics line-scan OCT for cellular-resolution optoretinography." Biomedical Optics Express 11, no. 9 (August 26, 2020): 5274. http://dx.doi.org/10.1364/boe.399034.

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4

Ma, Guangying, Taeyoon Son, Tae-Hoon Kim, and Xincheng Yao. "Functional optoretinography: concurrent OCT monitoring of intrinsic signal amplitude and phase dynamics in human photoreceptors." Biomedical Optics Express 12, no. 5 (April 9, 2021): 2661. http://dx.doi.org/10.1364/boe.423733.

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5

Kim, Tae-Hoon, Benquan Wang, Yiming Lu, Taeyoon Son, and Xincheng Yao. "Functional optical coherence tomography enables in vivo optoretinography of photoreceptor dysfunction due to retinal degeneration." Biomedical Optics Express 11, no. 9 (August 27, 2020): 5306. http://dx.doi.org/10.1364/boe.399334.

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6

Vienola, Kari V., Robert J. Zawadzki, and Ravi S. Jonnal. "Contributed Session I: Towards clinically friendly optoretinography (ORG) using 100 kHz swept-source OCT without adaptive optics (AO)." Journal of Vision 22, no. 3 (February 1, 2022): 4. http://dx.doi.org/10.1167/jov.22.3.4.

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7

КИМ, А. Л., and Г. Ж. КАПАНОВА. "OPTICAL COHERENCE TOMOGRAPHY IN OPHTHALMOLOGY: A REVIEW." Farmaciâ Kazahstana, no. 1 (May 19, 2022): 15–21. http://dx.doi.org/10.53511/pharmkaz.2022.91.69.004.

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Актуальность: В различных литературных источниках встречается более 75 000 публикаций, связанных с оптической когерентной томографией (ОКТ). ОКТ стала одной из самых быстро и успешно проводимых методов визуализации со значительной клинической и экономической эффективностью. ОКТ впервые была применена для визуализации структур глаза более 20 лет назад и до сих пор остается незаменимой в офтальмологии. С помощью ОКТ стало возможно неинвазивно получать оптические срезы тканей с разрешением выше, чем у любого другого метода. Динамическое развитие науки и техники привело к повышению чувствительности аппаратов ОКТ, увеличению разрешающей способности, скорости сканирования. В данном обзоре рассматривается развитие метода ОКТ, представлены данные о современных ОКТ-приборах.Цель: изучить ключевые технологии и перспективные инновации ОКТ глаза.Материалы и методы: всесторонний обзор современных достижений в области ОКТ глаза.Результаты: наиболее революционные будущие инновации ОКТ включают улучшение разрешения и скорости визуализации, новые реализации для двухмодальных или даже мультимодальных систем, а также использование эндогенного или экзогенного контраста в этих гибридных системах ОКТ, ориентированных на молекулярную и метаболическую визуализацию. Некоторые недавно разработанные расширения, например, оптическая когерентная эластография, динамическая контрастная ОКТ, опторетинография и ОКТ с искусственным интеллектом, также имеют большой потенциал в будущем. Перевод OКT глаза в широкую клиническую практику, включая нормативные требования к медицинскому оборудованию, остается попрежнему крайне важным.Выводы. Обладая превосходной неинвазивной способностью делать срезы по глубине с микрометровым разрешением, ОКТ является самой быстро внедряемой технологией визуализации в офтальмологии. Тем не менее, ОКТ используется не полностью и имеет значительный потенциал роста. Это относится не только к области применения в офтальмологии, но и к изначальной цели ОКТ сделать возможной оптическую биопсию, т. е. визуализацию микроструктуры ткани in situ с разрешением, приближающимся к гистологическому, но без необходимости иссечения ткани. Introduction: There are more than 75,000 publications related to optical coherence tomography (OCT) in various literary sources. OCT has become one of the fastest and most successful imaging modalities with signi cant clinical and costeffectiveness. OCT was rst used to visualize the structures of the eye more than 20 years ago and still remains indispensable in ophthalmology. With the help of OCT, it has become possible to noninvasively obtain optical sections of tissues with a resolution higher than that of any other method. The dynamic development of science and technology has led to an increase in the sensitivity of OCT devices, an increase in resolution, and scanning speed. This review discusses the development of the OCT method and presents data on modern OCT devices.Objective: to explore key technologies and promising innovations in OCT of the eye.Materials and Methods: A Comprehensive Review of Current Advances in OCT of the Eye.Results: The most revolutionary future OCT innovations include improvements in imaging resolution and speed, new implementations for bimodal or even multimodal systems, and the use of endogenous or exogenous contrast in these hybrid OCT systems focused on molecular and metabolic imaging. Some recently developed extensions, such as optical coherence elastography, dynamic contrast OCT, optoretinography, and AIassisted OCT, also have great potential for the future. The translation of OCT of the eye into broad clinical practice, including regulatory requirements for medical devices, remains critical.Conclusions. With its excellent noninvasive ability to make micrometerresolution depth slices, OCT is the fastestgrowing imaging technology in ophthalmology. However, OCT is underused and has signi cant growth potential. This applies not only to the eld of application in ophthalmology, but also to the original purpose of OCT to enable optical biopsy, i.e. in situ visualization of tissue microstructure with a resolution approaching histological, but without the need for tissue excision.

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8

Roorda, Austin. "Optoretinography is coming of age." Proceedings of the National Academy of Sciences 118, no. 51 (December 14, 2021). http://dx.doi.org/10.1073/pnas.2119737118.

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9

Vienola, Kari, Denise Valente, Robert Zawadzki, and Ravi Jonnal. "Velocity-based optoretinography for clinical applications." Optica, August 29, 2022. http://dx.doi.org/10.1364/optica.460835.

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10

Pandiyan, Vimal, Sierra Schleufer, Emily Slezak, James Fong, RISHI UPADHYAY, Austin Roorda, Ren Ng, and Ramkumar Sabesan. "Characterizing Cone Spectral Classification by Optoretinography." Biomedical Optics Express, November 9, 2022. http://dx.doi.org/10.1364/boe.473608.

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11

Kim, Tae-Hoon, Jie Ding, and Xincheng Yao. "Intrinsic signal optoretinography of dark adaptation kinetics." Scientific Reports 12, no. 1 (February 15, 2022). http://dx.doi.org/10.1038/s41598-022-06562-4.

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AbstractDelayed dark adaptation due to impaired rod photoreceptor homeostasis has been reported as the earliest symptom of eye diseases such as age-related macular degeneration, diabetic retinopathy, and retinitis pigmentosa. Objective measurement of dark adaptation can facilitate early diagnosis to enable prompt intervention to prevent vision loss. However, there is a lack of noninvasive methods capable of spatiotemporal monitoring of photoreceptor changes during dark adaptation. Here we demonstrate functional optical coherence tomography (OCT) for in vivo intrinsic signal optoretinography (ORG) of dark adaptation kinetics in the C57BL/6J mouse retina. Functional OCT revealed a shortening of the outer retina, a rearrangement of the cone and rod photoreceptor interdigitation zone, and a reduction in intrinsic signal amplitude at the photoreceptor inner segment ellipsoid (ISe). A strong positive correlation between the outer retinal shortening and ISe intensity reduction was also confirmed. Functional OCT of dark adaptation kinetics promises an objective method for rapid ORG assessment of physiological integrity of retinal photoreceptors.

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12

Lassoued, Ayoub, Furu Zhang, Kazuhiro Kurokawa, Yan Liu, Marcel T. Bernucci, James A. Crowell, and Donald T. Miller. "Cone photoreceptor dysfunction in retinitis pigmentosa revealed by optoretinography." Proceedings of the National Academy of Sciences 118, no. 47 (November 18, 2021). http://dx.doi.org/10.1073/pnas.2107444118.

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Significance Many blinding diseases afflict photoreceptors, specialized cells in the retina that capture and transduce light to initiate vision. Biomarkers that are sensitive to photoreceptor health are crucial for early detection and effective treatment monitoring of these diseases yet remain elusive. Here, we develop an optical biomarker, based on optoretinographic photoreceptor responses to light stimulation, that reflects the degree of dysfunction of individual cone photoreceptors in patients with retinitis pigmentosa (RP), the most common inherited retinal degenerative disease. Our results show that this biomarker may be beneficial for assessing the functionality of remaining retinal cells in RP patients and for assessing efficacy of treatments such as gene therapy and stem cell transplantation for RP and other diseases afflicting photoreceptors.

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13

Son, Taeyoon, Tae-Hoon Kim, Guangying Ma, Hoonsup Kim, and Xincheng Yao. "Functional intrinsic optical signal imaging for objective optoretinography of human photoreceptors." Experimental Biology and Medicine, December 13, 2020, 153537022097889. http://dx.doi.org/10.1177/1535370220978898.

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Functional mapping of photoreceptor physiology is important for better disease diagnosis and treatment assessment. Fast intrinsic optical signal (IOS), which arises before light-evoked pupillary response, promises a unique biomarker of photoreceptor physiology for objective optoretinography with high resolution. This study is to test the feasibility of non-mydriatic IOS mapping of retinal photoreceptors in awake human. Depth-resolved optical coherence tomography verified outer segment (OS) as the anatomic origin of fast photoreceptor-IOS. Dynamic IOS changes are primarily confined at OS boundaries connected with inner segment and retinal pigment epithelium, supporting transient OS shrinkage due to phototransduction process as the mechanism of the fast photoreceptor-IOS response.

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14

Ma, Guangying, Taeyoon Son, Tae‐Hoon Kim, and Xincheng Yao. "In vivo optoretinography of phototransduction activation and energy metabolism in retinal photoreceptors." Journal of Biophotonics 14, no. 5 (February 18, 2021). http://dx.doi.org/10.1002/jbio.202000462.

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15

jiang, xiaoyun, Teng Liu, Vimal Pandiyan, Emily Slezak, and Ramkumar Sabesan. "Coarse-scale Optoretinography(CoORG) with extended field-of-view for normative characterization." Biomedical Optics Express, October 14, 2022. http://dx.doi.org/10.1364/boe.473475.

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16

Kim, Tae-Hoon, Guangying Ma, Taeyoon Son, and Xincheng Yao. "Functional Optical Coherence Tomography for Intrinsic Signal Optoretinography: Recent Developments and Deployment Challenges." Frontiers in Medicine 9 (April 4, 2022). http://dx.doi.org/10.3389/fmed.2022.864824.

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Intrinsic optical signal (IOS) imaging of the retina, also termed as optoretinogram or optoretinography (ORG), promises a non-invasive method for the objective assessment of retinal function. By providing the unparalleled capability to differentiate individual retinal layers, functional optical coherence tomography (OCT) has been actively investigated for intrinsic signal ORG measurements. However, clinical deployment of functional OCT for quantitative ORG is still challenging due to the lack of a standardized imaging protocol and the complication of IOS sources and mechanisms. This article aims to summarize recent developments of functional OCT for ORG measurement, OCT intensity- and phase-based IOS processing. Technical challenges and perspectives of quantitative IOS analysis and ORG interpretations are discussed.

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17

Pandiyan, Vimal Prabhu, Phoung T. Nguyen, Edward N. Pugh, and Ramkumar Sabesan. "Human cone elongation responses can be explained by photoactivated cone opsin and membrane swelling and osmotic response to phosphate produced by RGS9-catalyzed GTPase." Proceedings of the National Academy of Sciences 119, no. 39 (September 19, 2022). http://dx.doi.org/10.1073/pnas.2202485119.

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Human cone outer segment (COS) length changes in response to stimuli bleaching up to 99% of L- and M-cone opsins were measured with high resolution, phase-resolved optical coherence tomography (OCT). Responses comprised a fast phase (∼5 ms), during which COSs shrink, and two slower phases (1.5 s), during which COSs elongate. The slower components saturated in amplitude (∼425 nm) and initial rate (∼3 nm ms −1 ) and are well described over the 200-fold bleaching range as the sum of two exponentially rising functions with time constants of 80 to 90 ms (component 1) and 1,000 to 1,250 ms (component 2). Measurements with adaptive optics reflection densitometry revealed component 2 to be linearly related to cone pigment bleaching, and the hypothesis is proposed that it arises from cone opsin and disk membrane swelling triggered by isomerization and rate-limited by chromophore hydrolysis and its reduction to membrane-localized all-trans retinol. The light sensitivity and kinetics of component 1 suggested that the underlying mechanism is an osmotic response to an amplified soluble by-product of phototransduction. The hypotheses that component 1 corresponds to G-protein subunits dissociating from the membrane, metabolites of cyclic guanosine monophosphate (cGMP) hydrolysis, or by-products of activated guanylate cyclase are rejected, while the hypothesis that it corresponds to phosphate produced by regulator of G-protein signaling 9 (RGS9)-catalyzed hydrolysis of guanosine triphosphate (GTP) in G protein–phosphodiesterase complexes was found to be consistent with the results. These results provide a basis for the assessment with optoretinography of phototransduction in individual cone photoreceptors in health and during disease progression and therapeutic interventions.

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