Journal articles on the topic 'Optical Tweezers'

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1

YOUPLAO, P., T. PHATTARAWORAMET, S. MITATHA, C. TEEKA, and P. P. YUPAPIN. "NOVEL OPTICAL TRAPPING TOOL GENERATION AND STORAGE CONTROLLED BY LIGHT." Journal of Nonlinear Optical Physics & Materials 19, no. 02 (June 2010): 371–78. http://dx.doi.org/10.1142/s0218863510005182.

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We propose a novel system of an optical trapping tool using a dark-bright soliton pulse-propagating within an add/drop optical filter. The multiplexing signals with different wavelengths of the dark soliton are controlled and amplified within the system. The dynamic behavior of dark bright soliton interaction is analyzed and described. The storage signal is controlled and tuned to be an optical probe which can be configured as the optical tweezer. The optical tweezer storage is embedded within the add/drop optical filter system. By using some suitable parameters, we found that the tweezers storage time of 1.2 ns is achieved. Therefore, the generated optical tweezers can be stored and amplified within the design system. In application, the optical tweezers can be stored and trapped light/atom, which can be transmitted and recovered by using the proposed system.
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2

Sun, Rui, Xin Wang, Kong Zhang, Jun He, and Junmin Wang. "Influence of Laser Intensity Fluctuation on Single-Cesium Atom Trapping Lifetime in a 1064-nm Microscopic Optical Tweezer." Applied Sciences 10, no. 2 (January 16, 2020): 659. http://dx.doi.org/10.3390/app10020659.

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An optical tweezer composed of a strongly focused single-spatial-mode Gaussian beam of a red-detuned 1064-nm laser can confine a single-cesium (Cs) atom at the strongest point of the light intensity. We can use this for coherent manipulation of single-quantum bits and single-photon sources. The trapping lifetime of the atoms in the optical tweezers is very short due to the impact of the background atoms, the parametric heating of the optical tweezer and the residual thermal motion of the atoms. In this paper, we analyzed the influence of the background pressure, the trap frequency of optical tweezers and the laser intensity fluctuation of optical tweezers on the atomic trapping lifetime. Combined with the external feedback loop based on an acousto-optical modulator (AOM), the intensity fluctuation of the 1064-nm laser in the time domain was suppressed from ±3.360% to ±0.064%, and the suppression bandwidth in the frequency domain reached approximately 33 kHz. The trapping lifetime of a single-Cs atom in the microscopic optical tweezers was extended from 4.04 s to 6.34 s.
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3

Lee, Moosung, Hervé Hugonnet, Mahn Jae Lee, Youngmoon Cho, and YongKeun Park. "Optical trapping with holographically structured light for single-cell studies." Biophysics Reviews 4, no. 1 (March 2023): 011302. http://dx.doi.org/10.1063/5.0111104.

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A groundbreaking work in 1970 by Arthur Ashkin paved the way for developing various optical trapping techniques. Optical tweezers have become an established method for the manipulation of biological objects, due to their noninvasiveness and precise controllability. Recent innovations are accelerating and now enable single-cell manipulation through holographic light structuring. In this review, we provide an overview of recent advances in optical tweezer techniques for studies at the individual cell level. Our review focuses on holographic optical tweezers that utilize active spatial light modulators to noninvasively manipulate live cells. The versatility of the technology has led to valuable integrations with microscopy, microfluidics, and biotechnological techniques for various single-cell studies. We aim to recapitulate the basic principles of holographic optical tweezers, highlight trends in their biophysical applications, and discuss challenges and future prospects.
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4

Ukita, Hiroo. "Optical tweezers." IEEJ Transactions on Sensors and Micromachines 116, no. 1 (1996): 11–15. http://dx.doi.org/10.1541/ieejsmas.116.11.

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5

Ulanowski, Z. J., and Ian R. Williams. "Optical tweezers." Physics Education 31, no. 3 (May 1996): 179–82. http://dx.doi.org/10.1088/0031-9120/31/3/020.

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6

Zhao, Xiaoting, Nan Zhao, Yang Shi, Hongbao Xin, and Baojun Li. "Optical Fiber Tweezers: A Versatile Tool for Optical Trapping and Manipulation." Micromachines 11, no. 2 (January 21, 2020): 114. http://dx.doi.org/10.3390/mi11020114.

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Optical trapping is widely used in different areas, ranging from biomedical applications, to physics and material sciences. In recent years, optical fiber tweezers have attracted significant attention in the field of optical trapping due to their flexible manipulation, compact structure, and easy fabrication. As a versatile tool for optical trapping and manipulation, optical fiber tweezers can be used to trap, manipulate, arrange, and assemble tiny objects. Here, we review the optical fiber tweezers-based trapping and manipulation, including dual fiber tweezers for trapping and manipulation, single fiber tweezers for trapping and single cell analysis, optical fiber tweezers for cell assembly, structured optical fiber for enhanced trapping and manipulation, subwavelength optical fiber wire for evanescent fields-based trapping and delivery, and photothermal trapping, assembly, and manipulation.
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7

Samadi, Akbar, and Nader S. Reihani. "Optimal beam diameter for optical tweezers." Optics Letters 35, no. 10 (May 4, 2010): 1494. http://dx.doi.org/10.1364/ol.35.001494.

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8

Chiou, Arthur E., Wen Wang, Greg J. Sonek, John Hong, and M. W. Berns. "Interferometric Optical Tweezers." Optics and Photonics News 7, no. 12 (December 1, 1996): 11. http://dx.doi.org/10.1364/opn.7.12.000011.

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9

Chiou, Arthur E., Wen Wang, Greg J. Sonek, John Hong, and M. W. Berns. "Interferometric optical tweezers." Optics Communications 133, no. 1-6 (January 1997): 7–10. http://dx.doi.org/10.1016/s0030-4018(96)00456-7.

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10

Reece, Peter J. "Finer optical tweezers." Nature Photonics 2, no. 6 (June 2008): 333–34. http://dx.doi.org/10.1038/nphoton.2008.88.

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11

GAO, Hongyu, and Danni YU. "Application of Optical Tweezers and Raman Tweezers." ACTA BIOPHYSICA SINICA 28, no. 3 (January 7, 2013): 212–23. http://dx.doi.org/10.3724/sp.j.1260.2012.10112.

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12

Tanaka, Yoshio, and Ken’ichi Fujimoto. "Dual-Arm Visuo-Haptic Optical Tweezers for Bimanual Cooperative Micromanipulation of Nonspherical Objects." Micromachines 13, no. 11 (October 26, 2022): 1830. http://dx.doi.org/10.3390/mi13111830.

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Cooperative manipulation through dual-arm robots is widely implemented to perform precise and dexterous tasks to ensure automation; however, the implementation of cooperative micromanipulation through dual-arm optical tweezers is relatively rare in biomedical laboratories. To enable the bimanual and dexterous cooperative handling of a nonspherical object in microscopic workspaces, we present a dual-arm visuo-haptic optical tweezer system with two trapped microspheres, which are commercially available end-effectors, to realize indirect micromanipulation. By combining the precise correction technique of distortions in scanning optical tweezers and computer vision techniques, our dual-arm system allows a user to perceive the real contact forces during the cooperative manipulation of an object. The system enhances the dexterity of bimanual micromanipulation by employing the real-time representation of the forces and their directions. As a proof of concept, we demonstrate the cooperative indirect micromanipulation of single nonspherical objects, specifically, a glass fragment and a large diatom. Moreover, the precise correction method of the scanning optical tweezers is described. The unique capabilities offered by the proposed dual-arm visuo-haptic system can facilitate research on biomedical materials and single-cells under an optical microscope.
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13

Keloth, Anusha, Owen Anderson, Donald Risbridger, and Lynn Paterson. "Single Cell Isolation Using Optical Tweezers." Micromachines 9, no. 9 (August 29, 2018): 434. http://dx.doi.org/10.3390/mi9090434.

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Optical tweezers offer a non-contact method for selecting single cells and translocating them from one microenvironment to another. We have characterized the optical tweezing of yeast S. cerevisiae and can manipulate single cells at 0.41 ± 0.06 mm/s using a 26.8 ± 0.1 mW from a 785 nm diode laser. We have fabricated and tested three cell isolation devices; a micropipette, a PDMS chip and a laser machined fused silica chip and we have isolated yeast, single bacteria and cyanobacteria cells. The most effective isolation was achieved in PDMS chips, where single yeast cells were grown and observed for 18 h without contamination. The duration of budding in S. cerevisiae was not affected by the laser parameters used, but the time from tweezing until the first budding event began increased with increasing laser energy (laser power × time). Yeast cells tweezed using 25.0 ± 0.1 mW for 1 min were viable after isolation. We have constructed a micro-consortium of yeast cells, and a co-culture of yeast and bacteria, using optical tweezers in combination with the PDMS network of channels and isolation chambers, which may impact on both industrial biotechnology and understanding pathogen dynamics.
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14

Zhang, D. W., and X. C. Yuan. "Optical doughnut for optical tweezers." Optics Letters 28, no. 9 (May 1, 2003): 740. http://dx.doi.org/10.1364/ol.28.000740.

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15

ZHENG Ming-jie, 郑明杰. "Parameter Evaluation of Optical Tweezers System Using Optical Tweezers Computational Toolbox." ACTA PHOTONICA SINICA 40, no. 12 (2011): 1884–87. http://dx.doi.org/10.3788/gzxb20114012.1884.

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16

Zhu, Yuchen, Minmin You, Yuzhi Shi, Haiyang Huang, Zeyong Wei, Tao He, Sha Xiong, Zhanshan Wang, and Xinbin Cheng. "Optofluidic Tweezers: Efficient and Versatile Micro/Nano-Manipulation Tools." Micromachines 14, no. 7 (June 28, 2023): 1326. http://dx.doi.org/10.3390/mi14071326.

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Optical tweezers (OTs) can transfer light momentum to particles, achieving the precise manipulation of particles through optical forces. Due to the properties of non-contact and precise control, OTs have provided a gateway for exploring the mysteries behind nonlinear optics, soft-condensed-matter physics, molecular biology, and analytical chemistry. In recent years, OTs have been combined with microfluidic chips to overcome their limitations in, for instance, speed and efficiency, creating a technology known as “optofluidic tweezers.” This paper describes static OTs briefly first. Next, we overview recent developments in optofluidic tweezers, summarizing advancements in capture, manipulation, sorting, and measurement based on different technologies. The focus is on various kinds of optofluidic tweezers, such as holographic optical tweezers, photonic-crystal optical tweezers, and waveguide optical tweezers. Moreover, there is a continuing trend of combining optofluidic tweezers with other techniques to achieve greater functionality, such as antigen–antibody interactions and Raman tweezers. We conclude by summarizing the main challenges and future directions in this research field.
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17

Vogt, Nina. "High-resolution optical tweezers." Nature Methods 18, no. 4 (April 2021): 333. http://dx.doi.org/10.1038/s41592-021-01121-7.

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18

Khosravi, Mohammad Hossein, Vahid Shahabadi, and Faegheh Hajizadeh. "Microsphere-coupled optical tweezers." Optics Letters 46, no. 17 (August 19, 2021): 4124. http://dx.doi.org/10.1364/ol.431271.

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19

Pu, Jixiong, and P. H. Jones. "Devil’s lens optical tweezers." Optics Express 23, no. 7 (March 23, 2015): 8190. http://dx.doi.org/10.1364/oe.23.008190.

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20

Pool, R. "Trapping with optical tweezers." Science 241, no. 4869 (August 26, 1988): 1042. http://dx.doi.org/10.1126/science.3045966.

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21

Villarroel, Javier, Héctor Burgos, Ángel García-Cabañes, Mercedes Carrascosa, Alfonso Blázquez-Castro, and Fernando Agulló-López. "Photovoltaic versus optical tweezers." Optics Express 19, no. 24 (November 14, 2011): 24320. http://dx.doi.org/10.1364/oe.19.024320.

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22

Molloy, Justin E., and Miles J. Padgett. "Lights, action: Optical tweezers." Contemporary Physics 43, no. 4 (July 2002): 241–58. http://dx.doi.org/10.1080/00107510110116051.

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23

Kricka, Larry J. "Optical Tweezers and Immunoassay." Clinical Chemistry 43, no. 2 (February 1, 1997): 251–53. http://dx.doi.org/10.1093/clinchem/43.2.251.

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24

Yao, Alison, Manlio Tassieri, Miles Padgett, and Jonathan Cooper. "Microrheology with optical tweezers." Lab on a Chip 9, no. 17 (2009): 2568. http://dx.doi.org/10.1039/b907992k.

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25

Padgett, Miles, and Les Allen. "Optical tweezers and spanners." Physics World 10, no. 9 (September 1997): 35–40. http://dx.doi.org/10.1088/2058-7058/10/9/22.

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26

Evanko, Daniel. "Optimizing your optical tweezers." Nature Methods 3, no. 8 (August 2006): 584–85. http://dx.doi.org/10.1038/nmeth0806-584b.

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27

Shaw, L. A., C. M. Spadaccini, and J. B. Hopkins. "Scanning holographic optical tweezers." Optics Letters 42, no. 15 (July 17, 2017): 2862. http://dx.doi.org/10.1364/ol.42.002862.

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28

Mahmoudi, Ali, and S. Nader S. Reihani. "Phase contrast optical tweezers." Optics Express 18, no. 17 (August 6, 2010): 17983. http://dx.doi.org/10.1364/oe.18.017983.

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29

Preece, Daryl, Rebecca Warren, R. M. L. Evans, Graham M. Gibson, Miles J. Padgett, Jonathan M. Cooper, and Manlio Tassieri. "Optical tweezers: wideband microrheology." Journal of Optics 13, no. 4 (March 4, 2011): 044022. http://dx.doi.org/10.1088/2040-8978/13/4/044022.

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30

Curtis, Jennifer E., Brian A. Koss, and David G. Grier. "Dynamic holographic optical tweezers." Optics Communications 207, no. 1-6 (June 2002): 169–75. http://dx.doi.org/10.1016/s0030-4018(02)01524-9.

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31

Juan, Mathieu L., Maurizio Righini, and Romain Quidant. "Plasmon nano-optical tweezers." Nature Photonics 5, no. 6 (May 31, 2011): 349–56. http://dx.doi.org/10.1038/nphoton.2011.56.

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32

Mohammadnezhad, Mohammadbagher, and Abdollah Hassanzadeh. "Multibeam interferometric optical tweezers." Journal of Nanophotonics 11, no. 3 (July 27, 2017): 036007. http://dx.doi.org/10.1117/1.jnp.11.036007.

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33

Nieminen, Timo A., Vincent L. Y. Loke, Alexander B. Stilgoe, Gregor Knöner, Agata M. Brańczyk, Norman R. Heckenberg, and Halina Rubinsztein-Dunlop. "Optical tweezers computational toolbox." Journal of Optics A: Pure and Applied Optics 9, no. 8 (July 24, 2007): S196—S203. http://dx.doi.org/10.1088/1464-4258/9/8/s12.

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34

Bola, R., D. Treptow, A. Marzoa, M. Montes-Usategui, and E. Martín-Badosa. "Acousto-holographic optical tweezers." Optics Letters 45, no. 10 (May 15, 2020): 2938. http://dx.doi.org/10.1364/ol.391462.

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35

Neto, P. A. Maia, and H. M. Nussenzveig. "Theory of optical tweezers." Europhysics Letters (EPL) 50, no. 5 (June 1, 2000): 702–8. http://dx.doi.org/10.1209/epl/i2000-00327-4.

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36

van Mameren, Joost, and Anna Wozniak. "Nanomanipulation with Optical Tweezers." Imaging & Microscopy 11, no. 1 (March 2009): 32–34. http://dx.doi.org/10.1002/imic.200990012.

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37

Bowman, Richard W., Graham M. Gibson, Anna Linnenberger, David B. Phillips, James A. Grieve, David M. Carberry, Steven Serati, Mervyn J. Miles, and Miles J. Padgett. "“Red Tweezers”: Fast, customisable hologram generation for optical tweezers." Computer Physics Communications 185, no. 1 (January 2014): 268–73. http://dx.doi.org/10.1016/j.cpc.2013.08.008.

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38

Tasakorn, M., N. Pornsuwancharoen, P. P. Yupapin, and S. Thongmee. "A New Design Optical Tweezers by Triple Ring Resonator." Advanced Materials Research 979 (June 2014): 504–7. http://dx.doi.org/10.4028/www.scientific.net/amr.979.504.

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We propose a new system of the multi-quantum tweezers array generation using a soliton generation control within the triple ring resonator system, whereas the dynamic tweezers can be generated within a microring device. By using the quantum processor, the entangle photon states of the tweezers can be formed, which is allowed to form the molecular quantum transmission. We have also theoretically shown that the optical tweezers can be controlled and tuned by varying the couple coefficient (κ) between 0.25 and 0.9, with ring resonator radii between 7 and 15 μm, which is available for molecule trapping. In application, the transmission of tweezers with different molecules or DNA can be performed, which is available for high density and security molecular transportation via the optical communication system.
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39

Ongrungrueng, Thamonwan, Sitti Buathong, Supasilp Fuengfung, and Sarayut Deachapunya. "Home-made optical tweezers for biomedical applications." Journal of Physics: Conference Series 2653, no. 1 (December 1, 2023): 012077. http://dx.doi.org/10.1088/1742-6596/2653/1/012077.

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Abstract Optical tweezers has been built with confocal fluorescence microscope as based detection. Microsphere particles and 780 nm fluorescence dye molecules are used in our demonstration. With the combination between these two particles, light focusing and particle manipulation can be performed simultaneously. The experimental results show that the tweezers can trap and move particles and even rotate the clusters of dye molecules sharply. We aim to apply our tweezers to biomedical applications such biological samples in the near future.
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40

Li, Yi Zhi, Shun Quan Shen, and An Pei Ye. "The Electronic Control System of Automatic Optical Scissors and Optical Tweezers." Applied Mechanics and Materials 423-426 (September 2013): 2894–98. http://dx.doi.org/10.4028/www.scientific.net/amm.423-426.2894.

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Optical tweezers and optical scissors is becoming a widely used technology. However, optical tweezers system that has been used, is not well automatic and convenient to operate. This article will introduce an automatic control system, mainly by describing the design, the composition and function of the system, which can automatically control each part of the entire platform by using a computer. The spatial resolution of the system has reached sub-nanometer level.
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41

van Mameren, Joost, Anna Wozniak, and Sid Ragona. "Single-Molecule DNA Stretching Using Optical Tweezers." Microscopy Today 17, no. 1 (January 2009): 42–43. http://dx.doi.org/10.1017/s1551929500055012.

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The advent of techniques to mechanically manipulate single (bio)molecules has sparked large efforts to precisely study the mechanical and elastic properties of proteins, protein fibers, DNA, RNA, etc. Two widely used techniques in this area are atomic force microscopy (AFM) and optical tweezers. Optical tweezers complement AFM at the lower end of the force regime: forces of typically a few hundred picoNewtons down to fractions of a picoNewton can be assessed using optical tweezers. This has allowed for, among other things, the precise measurement of forces and displacements exerted by individual motor proteins. In this report, we focus on the use of optical tweezers for force spectroscopy on single DNA molecules, and on the range of applications that this technique offers to learn not only about DNA itself, but also about the mechanics and thermodynamics of protein-DNA interaction.
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42

Kuo, Scot C. "Optical Tweezers: A Practical Guide." Microscopy and Microanalysis 1, no. 2 (June 1995): 65–74. http://dx.doi.org/10.1017/s143192769511065x.

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Optical tweezers, or the single-beam optical gradient force trap, is becoming a major tool in biology for noninvasive micromanipulation on an optical microscope. The principles and practical aspects that influence construction are presented in an introductory primer. Quantitative theories are also reviewed but have yet to supplant user calibration. Various biological applications are summarized, including recent quantitative force and displacement measurements. Finally, tantalizing developments for new, nonimaging microscopy techniques based on optical tweezers are included.
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43

Nishimoto, Kyohei, and Kozo Taguchi. "Combination of Au Dielectrophoresis Chip and Optical Tweezers for Cell Culture." Key Engineering Materials 656-657 (July 2015): 549–53. http://dx.doi.org/10.4028/www.scientific.net/kem.656-657.549.

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Dielectrophoresis (DEP) force will arise when an inhomogeneous AC electric field with sinusoidal wave is applied to microelectrodes. By using DEP, we could distinguish between viable and non-viable cells by their movement through a non-uniform electric field. In this paper, we propose a yeast cell separation system, which utilizes an Au DEP chip and an optical tweezers. The Au DEP chip is planar quadrupole microelectrodes, which were fabricated by Au thin-film and a box cutter. This fabrication method is low cost and simpler than previous existing methods. The tip of the optical tweezers was fabricated by dynamic chemical etching in a mixture of hydrogen fluoride and toluene. The optical tweezers has the feature of high manipulation performance. That does not require objective lens for focusing light because the tip of optical tweezers has conical shape. By using both the Au DEP chip and optical tweezers, we could obtain three-dimensional manipulation of specific cells after viability separation.
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44

Kotnala, Abhay, Pavana Siddhartha Kollipara, and Yuebing Zheng. "Opto-thermoelectric speckle tweezers." Nanophotonics 9, no. 4 (March 7, 2020): 927–33. http://dx.doi.org/10.1515/nanoph-2019-0530.

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AbstractOpto-thermoelectric tweezers present a new paradigm for optical trapping and manipulation of particles using low-power and simple optics. New real-life applications of opto-thermoelectric tweezers in areas such as biophysics, microfluidics, and nanomanufacturing will require them to have large-scale and high-throughput manipulation capabilities in complex environments. Here, we present opto-thermoelectric speckle tweezers, which use speckle field consisting of many randomly distributed thermal hotspots that arise from an optical speckle pattern to trap multiple particles over large areas. By further integrating the speckle tweezers with a microfluidic system, we experimentally demonstrate their application for size-based nanoparticle filtration. With their low-power operation, simplicity, and versatility, opto-thermoelectric speckle tweezers will broaden the applications of optical manipulation techniques.
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45

Oliveira, Leandro, Warlley Campos, and Marcio Rocha. "Optical Trapping and Manipulation of Superparamagnetic Beads Using Annular-Shaped Beams." Methods and Protocols 1, no. 4 (November 20, 2018): 44. http://dx.doi.org/10.3390/mps1040044.

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We propose an optical tweezers setup based on an annular-shaped laser beam that is efficient to trap 2.8 μ m-diameter superparamagnetic particles. The optical trapping of such particles was fully characterized, and a direct absolute comparison with a geometrical optics model was performed. With this comparison, we were able to show that light absorption by the superparamagnetic particles is negligible for our annular beam tweezers, differing from the case of conventional Gaussian beam tweezers, in which laser absorption by the beads makes stable trapping difficult. In addition, the trap stiffness of the annular beam tweezers increases with the laser power and with the bead distance from the coverslip surface. While this first result is expected and similar to that achieved for conventional Gaussian tweezers, which use ordinary dielectric beads, the second result is quite surprising and different from the ordinary case, suggesting that spherical aberration is much less important in our annular beam geometry. The results obtained here provide new insights into the development of hybrid optomagnetic tweezers, which can apply simultaneously optical and magnetic forces on the same particles.
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46

McGloin, David. "Optical tweezers: 20 years on." Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences 364, no. 1849 (October 18, 2006): 3521–37. http://dx.doi.org/10.1098/rsta.2006.1891.

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In 1986, Arthur Ashkin and colleagues published a seminal paper in Optics Letters , ‘Observation of a single-beam gradient force optical trap for dielectric particles’ which outlined a technique for trapping micrometre-sized dielectric particles using a focused laser beam, a technology which is now termed optical tweezers. This paper will provide a background in optical manipulation technologies and an overview of the applications of optical tweezers. It contains some recent work on the optical manipulation of aerosols and concludes with a critical discussion of where the future might lead this maturing technology.
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47

Ren Yuxuan, 任煜轩, 周金华 Zhou Jinhua, 吴建光 Wu Jianguang, and 李银妹 Li Yinmei. "Holographic Tweezers-The Most Vigorous Member in Optical Tweezers' Family." Laser & Optoelectronics Progress 45, no. 11 (2008): 35–41. http://dx.doi.org/10.3788/lop20084511.0035.

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48

Stangner, Tim, Tobias Dahlberg, Pontus Svenmarker, Johan Zakrisson, Krister Wiklund, Lene B. Oddershede, and Magnus Andersson. "Cooke–Triplet tweezers: more compact, robust, and efficient optical tweezers." Optics Letters 43, no. 9 (April 19, 2018): 1990. http://dx.doi.org/10.1364/ol.43.001990.

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49

Li, Jingang, Zhihan Chen, Yaoran Liu, Pavana Siddhartha Kollipara, Yichao Feng, Zhenglong Zhang, and Yuebing Zheng. "Opto-refrigerative tweezers." Science Advances 7, no. 26 (June 2021): eabh1101. http://dx.doi.org/10.1126/sciadv.abh1101.

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Abstract:
Optical tweezers offer revolutionary opportunities for both fundamental and applied research in materials science, biology, and medical engineering. However, the requirement of a strongly focused and high-intensity laser beam results in potential photon-induced and thermal damages to target objects, including nanoparticles, cells, and biomolecules. Here, we report a new type of light-based tweezers, termed opto-refrigerative tweezers, which exploit solid-state optical refrigeration and thermophoresis to trap particles and molecules at the laser-generated cold region. While laser refrigeration can avoid photothermal heating, the use of a weakly focused laser beam can further reduce the photodamages to the target object. This novel and noninvasive optical tweezing technique will bring new possibilities in the optical control of nanomaterials and biomolecules for essential applications in nanotechnology, photonics, and life science.
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50

Bao, Yicheng, Scarlett S. Yu, Loïc Anderegg, Eunmi Chae, Wolfgang Ketterle, Kang-Kuen Ni, and John M. Doyle. "Dipolar spin-exchange and entanglement between molecules in an optical tweezer array." Science 382, no. 6675 (December 8, 2023): 1138–43. http://dx.doi.org/10.1126/science.adf8999.

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Abstract:
Ultracold polar molecules are promising candidate qubits for quantum computing and quantum simulations. Their long-lived molecular rotational states form robust qubits, and the long-range dipolar interaction between molecules provides quantum entanglement. In this work, we demonstrate dipolar spin-exchange interactions between single calcium monofluoride (CaF) molecules trapped in an optical tweezer array. We realized the spin- 1 2 quantum XY model by encoding an effective spin- 1 2 system into the rotational states of the molecules and used it to generate a Bell state through an iSWAP operation. Conditioned on the verified existence of molecules in both tweezers at the end of the measurement, we obtained a Bell state fidelity of 0.89(6). Using interleaved tweezer arrays, we demonstrate single-site molecular addressability.
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