Dissertations / Theses on the topic 'Opioid consumption'
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Svendsen, Kristian. "Methodological Challenges in Pharmacoepidemiological Studies of Opioid Consumption." Doctoral thesis, Norges teknisk-naturvitenskapelige universitet, Institutt for samfunnsmedisin, 2012. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-17244.
Full textEverett, Bronwyn L., University of Western Sydney, and of Nursing Family and Community Health School. "The impact of linguistic diversity on postoperative opioid consumption." THESIS_CSHS_NFC_Everett_B.xml, 2000. http://handle.uws.edu.au:8081/1959.7/465.
Full textMaster of Science (Hons) (Health)
Everett, Bronwyn L. "The impact of linguistic diversity on postoperative opioid consumption /." View thesis, 2000. http://library.uws.edu.au/adt-NUWS/public/adt-NUWS20031118.123321/index.html.
Full text"March 2000" "A thesis presented to the University of Western Sydney Macarthur in partial fulfilment of the requirements for the Degree of Master of Science (Hons) Health" Bibliography: leaves 90-101.
Yu, Justin M. Eng (Justin K. )Massachusetts Institute of Technology. "Predicting post-surgical opioid consumption using perioperative surgical data." Thesis, Massachusetts Institute of Technology, 2020. https://hdl.handle.net/1721.1/130199.
Full text"May 2020." Date of graduation confirmed by MIT Registrar Office. Cataloged from student-submitted PDF of thesis.
Includes bibliographical references (pages 49-50).
Improper consumption of prescription opioids is a massive public health issue in the United States currently. Here, we propose one approach of tackling this issue through using machine learning techniques to predict opioid consumption post discharge for surgical patients. Through the data collected from surgical patients at BIDMC, relevant features will be identified and used to predict if patients high, outlier consumption. Using logistic regression and gradient boosted decision trees, model performance were evaluated at AUCs of 0.7270 and 0.7289 respectively.
by Justin Yu.
M. Eng.
M.Eng. Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science
Ploj, Karolina. "Involvement of the Opioid System in High Alcohol Consumption : Environmental and Genetic Influences." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2002. http://publications.uu.se/theses/91-554-5217-5/.
Full textGuo, Run Xiang, and jessica_guo2000@yahoo com. "The effect of electro-acupuncture on reducing opioid consumption in patients with chronic pain: a randomised controlled clinical trial." RMIT University. Health Sciences, 2007. http://adt.lib.rmit.edu.au/adt/public/adt-VIT20080703.161141.
Full textBeane, Amber. "Health and Academic Achievement in College and University Students." Digital Commons @ East Tennessee State University, 2020. https://dc.etsu.edu/etd/3702.
Full textSilva, Caroline Cristina. "Participação dos receptores opióides mu e kappa da substância cinzenta periaquedutal na febre induzida por estresse de contenção." Universidade Federal de São Carlos, 2016. https://repositorio.ufscar.br/handle/ufscar/7705.
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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
The endogenous opioids are involved in analgesia, thermoregulation and physiological responses to various stressful stimuli such as infection, psychological stress and hypoxia. The mu and kappa receptors in the hypothalamus play a role in endotoxin-induced fever and hypoxia-induced anapyrexia (opposite response to fever), respectively. In addition, periaqueductal gray (PAG), which express both mu and kappa receptors, is involved in defence and thermoregulatory responses. Thus, our hypothesis is that mu and kappa opioid receptors in the PAG modulate the restraint-induced fever in rats by activating and inhibiting this response, respectively. To this end, body temperature (Tb) and heat loss index (HLI; inference for heat conservation/loss) and oxygen consumption (VO ; inference for thermogenesis) of unanesthetized Wistar rats submitted or not to restraint stress, was monitored before and after intra-PAG microinjection of the selective mu opioid receptor antagonist (CTAP; 1 and 10 μg/ 100 nL/ animal), the selective kappa-opioid receptor antagonist (nor-BNI; 1 and 4 μg/ 100 nL/ animal), or vehicle (saline; 100nL/ animal). CTAP and nor-BNI did not change the Tb or the HLI of the animals in euthermia. During the restraint stress, Tb increased in all groups of animals. However, this effect was significantly lower in animals treated with CTAP, and significantly higher in animals treated with nor-BNI. No treatment affected HLI, but CTAP decreased thermogenesis and nor-BNI increased thermogenesis. The results indicate that the mu and kappa opioid receptors in the PAG of rats play a pyrogenic and antipyretic role, respectively, during fever induced by restraint stress and these receptors in PAG may not be essential for the maintenance of Tb during euthermia.
Os opióides endógenos estão envolvidos na analgesia, termorregulação e respostas fisiológicas a vários estímulos estressantes, como infecção, estresse psicológico e hipóxia. Os receptores mu e kappa no hipotálamo desempenham um papel na febre induzida por endotoxina e anapirexia induzida por hipoxia (resposta oposta à febre), respectivamente. Além disso, a substância cinzenta periaquedutal (PAG), que expressa ambos os receptores mu e kappa, está envolvida na defesa e respostas de termorregulação. Assim, nossa hipótese é que os receptores opióides mu e kappa na PAG modulam a febre induzida por contenção em ratos, ativando e inibindo esta resposta, respectivamente. Para este fim, a temperatura corporal (Tc) e o índice de perda de calor (IPC; inferência para a conservação/perda de calor) e o consumo de oxigênio (VO ; inferência para a termogênese) de ratos Wistar não anestesiados submetidos ou não ao estresse contenção, foi monitorado antes e depois microinjeção intra-PAG do antagonista seletivo do receptor opióide mu (CTAP; 1 e 10 μg/ 100 nL/ animal), antagonista seletivo do receptor opióide kappa (nor-BNI; 1 e 4 μg/ 100 nL/ animal) ou veículo (solução salina; 100 nL / animal). A microinjeção de CTAP ou nor-BNI não alterou a Tc ou IPC dos animais em eutermia. Durante o estresse de contenção, a Tc aumentou em todos os grupos de animais. No entanto, este efeito foi significativamente menor no grupo de animais tratados com CTAP, e significativamente maior em animais tratados com nor-BNI. Nenhum tratamento afetou o IPC, mas o CTAP diminuiu a termogênese e o nor-BNI aumentou a termogênese. Os resultados indicam que os receptores opióides mu e kappa na PAG de ratos desempenham um papel pirogênico e antipirético, respectivamente, durante a febre induzida pelo estresse de contenção e estes receptores na PAG podem não ser essenciais para a manutenção de Tc durante eutermia.
Daoura, Loudin. "Early Environment and Adolescent Ethanol Consumption : Effects on Endogenous Opioids and Behaviour in Rats." Doctoral thesis, Uppsala universitet, Institutionen för farmaceutisk biovetenskap, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-198670.
Full textLvovschi, Virginie-Eve. "Titration morphinique inhalée aux Urgences : modernisation de la prise en charge des douleurs sévères de l'adulte Targeting moderate pain in healthy volunteers by individual calibration of a nociceptive flexion reflex model Proposer un "modèle" de douleur provoquée par Electromyogramme pour optimiser les outils antalgiques aux urgences Nebulized versus intravenous morphine titration for the initial treatment of severe acute pain in the emergency department : study protocol for a multicenter, prospective randomized and controlled trial, CLIN-AEROMORPH Inhaled versus intravenous opioid dosing for the initial treatment of severe acute pain in the emergency department : pharmacological intermediate results of the CLIN-AEROMORPH french study Toward new eligibility criteria for ontravenous morphine in the French Emergency Department : Evaluation of physicians' bedside rationalization of opioid titration protocols Analysis of bedside determinisms leading to under-prescription of morphine titration in the Emergency Department : EPIMORPH study Medico-economic study of pain in an emergency department : a targeted literature review Opioid reflex at triage is not a solution for opioid-naive patients in emergency departments A systemic approach to complete the multimodal assessment model of pain Intravenous morphine titration to treat severe pain in the ED Morphine consumption is not modified in patients with severe pain and classified by the DN4 score as neuropathic Prise en charge de la douleur aiguë spontanée de l'adulte aux urgences." Thesis, Normandie, 2020. http://www.theses.fr/2020NORMR013.
Full textOur goal was to optimize the management of severe acute pain in emergency medicine. Intravenous morphine titration, which is currently the referent method, must be modernised to meet the new challenges of practice while at the same time, we must keep guaranteeing an unchanged risk-benefit balance in the fight against oligoanalgesia. Our work, described in this thesis, has been a cornerstone for the evaluation of a nebulized alternative solution to emergencies through 3 clinical studies, (AEROMORPH1, CLIN-AEROMORPH, EPIMORPH), and study of its contextualisation in literature. Work in healthy volunteers allowed us to establish a simple and accessible procedure for aerosol, of short duration (5 min), which can be repeated in titration procedures (every 10 min). Its feasibility is likely to be confirmed on our multicentre clinical study at a large scale and its efficacy, by a non-inferiority design of study is being evaluated. Pharmacological data in healthy volunteers and in patients confirm a blood morphine concentration close to the effective blood concentrations observed by intravenous administration (CLIN-AEROMORPH: 1-20 ng/ml), which is already a positive result demonstrated by our work. Moreover, regarding eligibility, our observational study, combined to a experiment about decision mechanisms, combined with the analysis of medico-economic data in literature, suggest the need to base its indication on more than just the simple VAS/NRS assessment at triage. In this work we showed that emergency practitioners’ practice today underlines their lack of adherence to the systematic initiation of intravenous morphine titration by patient self-assessment of severe pain (compliance with SFMU criteria 6 to 20%, re-assessment of VAS/NRS scores 61%). If nebulized morphine titration is only proposed as a starter for morphine titration without modernising the algorithms for opiate prescription decision in emergency protocols, it is likely that this new therapeutic proposal will only solve part of the current problem. Targeted pharmacological management, as individualised as possible, is more relevant than ever, with prescription of morphine titration according to the patient's typology, in addition to prioritisation by pain typology. By developing an original pain model in healthy volunteers, we have also highlighted profiles of "pain sensitive" and "enduring" patients, according to neurophysiological and biochemical data, that are certainly represented in daily clinical practice. Therefore, all these components should be taken into account to improve pain management in emergency medicine, with a more systemic vision and more dedicated studies using innovative evaluation methods, combining robust quantitative criteria with comprehensive qualitative criteria
Yu, Meei-Liam, and 余美蓮. "Opioid Analgesics Consumption and RelatedFactors in Hospitalized Cancer Patients- An example of National Health Insurance database." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/68003945036039705211.
Full text臺北醫學大學
護理學研究所
95
Pain is the most prevalent symptom in the majority of patients with cancer during hospitalization. Many of patients have not received adequate pain treatments.Inadequate pain management may compromise well being of the patients; therefore, pain control must be one of the priorities in caring for cancer patients. This study explored opioid analgesics consumption and related factors in hospitalized cancer patients . Cross-sectional design is used in is study . Hospitalized cancer patients using opioid drugs registered in the“2004 National Health Insurance Research Database” are selected as the study population. There are totally 163,780 cases. Descriptive analysis, t test, one-way ANOVA, and multiple regression analysis are used for data analysis. Rsults from this study indicate that pethidine is the most commonly used opioid for hospitalized cancer patients, with oral morphine being the second. The total morphine equivalent doses consumed annually by hospitalized cancer patients sum up to 45, 160,418mg. Because of the modest sample size, we present the DDD (defined daily dose) by per thousand patients. In this way, the hospitalized cancer patients of 2004 consumed 25.3 DDDs/thousand/day of morphine. The results of ANOVA show that patient, physician, and hospital characteristics significantly influence the opioid consumption (P <0.001). The result of multiple regression analysis also reveals that predictive factors affect the opioid usage (P<0.001). Hopefully this survey may serve the medical personnel and institutions as reference to cancer pain management, in order to improve life quality by relieving cancer pain timely and effectively for patients with cancer.
Clarke, Hance. "The Effects of Gabapentin on Pre-operative Anxiety, Morphine Consumption and Pain after Surgery." Thesis, 2013. http://hdl.handle.net/1807/35795.
Full textRamachandra, Vorani Sashrika. "Dopamine responses in the ventral straitum contribute to ethanol preference and consumption and, mu opioid receptors do not mediate ethanol stimulated dopamine release." Thesis, 2010. http://hdl.handle.net/2152/ETD-UT-2010-08-1698.
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Olsen, Andrew Edward. "A proposed study of supervised injection on Boston's "Recovery Road"." Thesis, 2018. https://hdl.handle.net/2144/33025.
Full textDoyon, William Maurice. "The effect of ethanol consumption on dopamine and ethanol concentrations in the nucleus accumbens during the development of reinforcement and the involvement of the k-Opioid receptor in the modulation of dopamine activity during ethanol self-administration." Thesis, 2005. http://hdl.handle.net/2152/2416.
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