Journal articles on the topic 'Oorah'
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Vranic, Valentino, and Milan Laslop. "Aspects and roles in software modeling: A composition based comparison." Computer Science and Information Systems 13, no. 1 (2016): 199–216. http://dx.doi.org/10.2298/csis151207065v.
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It?s intriguing how the work on inherent aspect-oriented modeling almost completely ignores the similarity between aspect-oriented and role based decomposition and composition. Ever since the notion of aspect entered the software development arena, it has been compared to the notion of role. Findings range from identifying greater similarities to more cautious observations that albeit aspects and roles are similar, they appear to be more as complimentary with a significant effort needed to really bring them together in programming. Even a cursory comparison of Theme/UML, which represents a design part of Theme, probably the best known and most comprehensive approach to aspect-oriented modeling, to OOram, a prominent representative of approaches to role based modeling that influenced UML, reveals striking similarities in both decomposition and composition. Within a more comprehensive effort of finding the principles of a sustainable approach to aspect-oriented modeling, this paper pursues further this observation by establishing a partially reversible transformation of a Theme/UML model to the corresponding OOram model that proves principal analogy of themes to OOram collaboration view diagrams accompanied by the corresponding scenario view and interface view diagrams. An important implication is that aspects have their counterpart not in roles themselves, but in role collaboration. Based on these results, a possibility of using UML composite structure diagrams for aspect-oriented design is sketched out in the paper.
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Graham, Ian. "Working with objects: The OOram software engineering method." Fuzzy Sets and Systems 82, no. 1 (August 1996): 130–31. http://dx.doi.org/10.1016/0165-0114(96)87709-8.
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Molina, Jesús García, María José Ortín, Begoña Moros, and Joaquín Nicolás. "Transforming the OOram Three-Model Architecture into a UML-based Process." Journal of Object Technology 1, no. 4 (2002): 119. http://dx.doi.org/10.5381/jot.2002.1.4.a2.
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Hughes, Nicky J., Chris L. Clayton, Peter A. Chalk, and David J. Kelly. "Helicobacter pylori porCDAB and oorDABCGenes Encode Distinct Pyruvate:Flavodoxin and 2-Oxoglutarate:Acceptor Oxidoreductases Which Mediate Electron Transport to NADP." Journal of Bacteriology 180, no. 5 (March 1, 1998): 1119–28. http://dx.doi.org/10.1128/jb.180.5.1119-1128.1998.
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ABSTRACT Helicobacter pylori, a major cause of human gastric disease, is a microaerophilic bacterium that contains neither pyruvate nor 2-oxoglutarate dehydrogenase activity. Previous studies (N. J. Hughes, P. A. Chalk, C. L. Clayton, and D. J. Kelly, J. Bacteriol. 177:3953–3959, 1995) have indicated that the major routes for the generation of acetyl coenzyme A (acetyl-CoA) and succinyl-CoA are via pyruvate:flavodoxin oxidoreductase (POR) and 2-oxoglutarate:acceptor oxidoreductase (OOR), respectively. The purified POR is a heterotetrameric protein, with subunits of 48 (PorA), 36 (PorB), 24 (PorC), and 14 (PorD) kDa. In this study OOR has been purified, and it is similarly composed of polypeptides of 43 (OorA), 33 (OorB), 24 (OorC), and 10 (OorD) kDa. Both POR and OOR are oxygen labile and are likely to be major contributors to the microaerophilic phenotype of H. pylori. Unlike POR, OOR was unable to use a previously identified flavodoxin (FldA) as an electron acceptor. Although the purified enzymes were unable to reduce NAD(P), electrons from both pyruvate and 2-oxoglutarate could reduce NADP in cell extracts, consistent with a role for these oxidoreductases in the provision of NADPH as a respiratory electron donor. The H. pylori por,oor, and fldA genes were cloned and sequenced. The deduced por gene products showed significant sequence similarity to archaeal four-subunit 2-oxoacid:acceptor oxidoreductases. However, the amino acid sequences of OorA and -B were more closely related to that of the two-subunit POR of the aerobic halophile Halobacterium halobium. BothporD and oorD encode integral ferredoxin-like subunits. POR and OOR are probably essential enzymes in H. pylori, as insertion inactivation of porB andoorA appeared to be lethal.
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Feinleib, Jessica, and Arthur French. "Standardization of US Veterans Health Administration system non-OR airway management through the OORAM educational program." Trends in Anaesthesia and Critical Care 30 (February 2020): e174-e175. http://dx.doi.org/10.1016/j.tacc.2019.12.428.
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Mulder, J. A., R. F. Berry, J. A. Halpin, S. Meffre, and J. L. Everard. "Depositional age and correlation of the Oonah Formation: refining the timing of Neoproterozoic basin formation in Tasmania." Australian Journal of Earth Sciences 65, no. 3 (February 15, 2018): 391–407. http://dx.doi.org/10.1080/08120099.2018.1426629.
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Sampath, Prabakaran, Sowmyapriya Rajalingam, Sharmila Murugesan, Rakesh Bhardwaj, and Veena Gupta. "Evaluation of Chemical Composition among the Multi Colored Germplasm of Abrus precatorius L." Plants 13, no. 14 (July 18, 2024): 1963. http://dx.doi.org/10.3390/plants13141963.
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The medicinal plant Abrus precatorius L. was traditionally used in the Siddha and Ayurvedic systems of medicine in India. The Indian center of origin holds a vast variability in its seed color. The objective of this study was to assess the total monomeric anthocyanin, flavonol, as well as the antioxidative potential, protein content and ash content among the accessions. A total of 99 accessions conserved in the Indian National Genebank were used in this study. The methods used for the estimation of total monomeric anthocyanin, flavonol, as well as the antioxidative potential, protein content and ash content were the pH differential method, Oomah method, Ferric Reducing Antioxidant Potential, Dumas method and gravimetric method, respectively. The completely black colored accession was recorded with highest total monomeric anthocyanin (51.95 mg/100 g of cyanidin 3-glucoside equivalent) and flavonol content (66.41 mg/g of quercetin equivalent). Red + black colored accessions have recorded the maximum value with respect to antioxidants (14.18 mg/g of gallic acid equivalent). The highest amount of protein content was found in a completely white colored accession (20.67%) and the maximum ash content was recorded in red + black colored accession (4.01%). The promising accessions identified can be used by pharmaceutical companies in drug development and in curing degenerative diseases.
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Knill, C. "Herbs, botanicals and teas G. Mazza, B.D. Oomah (Eds.); Technomic Publishing Co., Lancaster, PA, 2000, xvii+416 pp, ISBN 1-56676-851-9 (£77.00)." Carbohydrate Polymers 49, no. 4 (September 1, 2002): 516–17. http://dx.doi.org/10.1016/s0144-8617(01)00361-7.
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Takai, Ken, Barbara J. Campbell, S. Craig Cary, Masae Suzuki, Hanako Oida, Takuro Nunoura, Hisako Hirayama, et al. "Enzymatic and Genetic Characterization of Carbon and Energy Metabolisms by Deep-Sea Hydrothermal Chemolithoautotrophic Isolates of Epsilonproteobacteria." Applied and Environmental Microbiology 71, no. 11 (November 2005): 7310–20. http://dx.doi.org/10.1128/aem.71.11.7310-7320.2005.
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ABSTRACT The carbon and energy metabolisms of a variety of cultured chemolithoautotrophic Epsilonproteobacteria from deep-sea hydrothermal environments were characterized by both enzymatic and genetic analyses. All the Epsilonproteobacteria tested had all three key reductive tricarboxylic acid (rTCA) cycle enzymatic activities—ATP-dependent citrate lyase, pyruvate:ferredoxin oxidoreductase, and 2-oxoglutarate:ferredoxin oxidoreductase—while they had no ribulose 1,5-bisphosphate carboxylase (RubisCO) activity, the key enzyme in the Calvin-Benson cycle. These results paralleled the successful amplification of the key rTCA cycle genes aclB, porAB, and oorAB and the lack of success at amplifying the form I and II RubisCO genes, cbbL and cbbM. The combination of enzymatic and genetic analyses demonstrates that the Epsilonproteobacteria tested use the rTCA cycle for carbon assimilation. The energy metabolisms of deep-sea Epsilonproteobacteria were also well specified by the enzymatic and genetic characterization: hydrogen-oxidizing strains had evident soluble acceptor:methyl viologen hydrogenase activity and hydrogen uptake hydrogenase genes (hyn operon), while sulfur-oxidizing strains lacked both the enzyme activity and the genes. Although the energy metabolism of reduced sulfur compounds was not genetically analyzed and was not fully clarified, sulfur-oxidizing Epsilonproteobacteria showed enzyme activity of a potential sulfite:acceptor oxidoreductase for a direct oxidation pathway to sulfate but no activity of AMP-dependent adenosine 5′-phosphate sulfate reductase for a indirect oxidation pathway. No activity of thiosulfate-oxidizing enzymes was detected. The enzymatic and genetic characteristics described here were consistent with cellular carbon and energy metabolisms and suggest that molecular tools may have great potential for in situ elucidation of the ecophysiological roles of deep-sea Epsilonproteobacteria.
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Gilbreath, Jeremy J., Abby L. West, Oscar Q. Pich, Beth M. Carpenter, Sarah Michel, and D. Scott Merrell. "Fur Activates Expression of the 2-Oxoglutarate Oxidoreductase Genes (oorDABC) in Helicobacter pylori." Journal of Bacteriology 194, no. 23 (September 21, 2012): 6490–97. http://dx.doi.org/10.1128/jb.01226-12.
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ABSTRACTHelicobacter pyloriis a highly successful pathogen that colonizes the gastric mucosa of ∼50% of the world's population. Within this colonization niche, the bacteria encounter large fluctuations in nutrient availability. As such, it is critical that this organism regulate expression of key metabolic enzymes so that they are present when environmental conditions are optimal for growth. One such enzyme is the 2-oxoglutarate (α-ketoglutarate) oxidoreductase (OOR), which catalyzes the conversion of α-ketoglutarate to succinyl coenzyme A (succinyl-CoA) and CO2. Previous studies from our group suggested that the genes that encode the OOR are activated by iron-bound Fur (Fe-Fur); microarray analysis showed that expression ofoorD,oorA, andoorCwas altered in afurmutant strain ofH. pylori.The goal of the present work was to more thoroughly characterize expression of theoorDABCgenes inH. pylorias well as to define the role of Fe-Fur in this process. Here we show that these four genes are cotranscribed as an operon and that expression of the operon is decreased in afurmutant strain. Transcriptional start site mapping and promoter analysis revealed the presence of a canonical extended −10 element but a poorly conserved −35 element upstream of the +1. Additionally, we identified a conserved Fur binding sequence ∼130 bp upstream of the transcriptional start site. Transcriptional analysis using promoter fusions revealed that this binding sequence was required for Fe-Fur-mediated activation. Finally, fluorescence anisotropy assays indicate that Fe-Fur specifically bound this Fur box with a relatively high affinity (dissociation constant [Kd] = 200 nM). These findings provide novel insight into the genetic regulation of a key metabolic enzyme and add to our understanding of the diverse roles Fur plays in gene regulation inH. pylori.
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Galleguillos, Pedro A., Visnja Music, Mauricio Acosta, Camila N. Salazar, Raquel Quatrini, Amir Shmaryahu, David S. Holmes, et al. "Temporal Dynamics of Genes Involved in Metabolic Pathways of C and N of L. ferriphilum, in the Industrial Bioleaching Process of Escondida Mine, Chile." Advanced Materials Research 825 (October 2013): 162–65. http://dx.doi.org/10.4028/www.scientific.net/amr.825.162.
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The structure of the microbial community inhabiting the copper bioleaching heap at Escondida mine has been systematically monitored since the operation was started up (2006), using biomolecular and microbiological analyses. Recent molecular analyses showed thatL. ferriphilumwas one of the most abundant organisms in the process during year 2012. In order to study the biological dynamics of carbon and nitrogen in the process, the expression levels of thirteen genes ofL. ferriphilumwere analyzed by RT-qPCR. The 16S rRNA andalaSgenes were used as reference, and two relative quantification methods (ΔΔct and and Pffafl) were applied to estimate the relative expression levels of metabolic genes. On the day 110 of operation, a significant increment in the expression level of one gene involved in the cycle of tricarboxilic acids (2-oxoglutarate-acceptor oxidoreductase,oorA) was detected. By other hand, the expression level of two genes involved in carbohydrate metabolism (glgP, Glycogen phosphorilase, andglgA, Glycogen synthase) gradually increased, as the operation time progressed. The expression levels of genes involved in the fixation and assimilation of nitrogen increased at later stages of the process. A significant increase of the expression level of the gene annotated for Nitrogenase iron protein (nifH) was detected on the day 185 of operation. The opposite trend was observed for the gene annotated as Ammonium transporter protein (amt), as an elevated expression level was observed in earlier stages to suddenly decrease on the day 185 of operation, suggesting a change of the nitrogen source. In agreement with molecular quantitative analyses, this work confirmed thatL. ferriphilumwas an active member of the community during the period studied. This work gives new insights into biological dynamics of carbon and nitrogen, and suggests the potential guidelines to enhance the efficiency of biological components in industrial heap bioleaching processes.
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Adegbite, B. A., T. O. Osuolale, A. D. Arowolo, and K. F. Akinloye. "Agro-economic damages assessment of artisanal gold mining in Ijesa land, Osun State." Journal of Agricultural Science and Practice 8, no. 1 (February 28, 2023): 7–15. http://dx.doi.org/10.31248/jasp2022.394.
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To feed the expanding population, agriculture must be practiced in a more sustainable manner that improves productivity and the natural ecosystem. The main components of sustainable production systems that support the health of agro-ecosystems are people and the environment. The extractive nature of gold miners' practices has significant negative effects on the environment, which lower agricultural productivity due to the harm caused to the environment. The study aimed to determine the extent of ecosystem damage induced by bio-geochemical components of soil contaminated with heavy metals, which has an impact on agriculture and public health. Soil samples were collected from eight communities due to noticeable degradation levels, and characterized for heavy metals and other toxicants in the soil adopting standard procedures. The results revealed wider variations in the concentration of heavy metals and other toxicants between the degraded and non-degraded forestland as control. The mean heavy metals (mg/kg) in the soil at Ido Ijesa/Campus area was recorded as Hg (1.07), Cd (8.52), Ar (42.77), and Pb (118.71); At Isua, Hg (0.64), Cd (8.33), Ar (32.74), and Pb (295.72); while Iperindo/Imogara/Odo Ijesa recorded Hg (1.33), Cd (10.47), Ar (21.78), and Pb (115.64) and OOra/Iregun community had Hg (2.06), Cd (6.74), Ar (35.75), and Pb (85.74) respectively. The mean Cyanide contents in degraded site against non-degraded site were recorded as 89.64 mg/kg against 25.50 mg/kg (3.5:1) at Ido Ijesa/Campus area; 102.51mg/kg against 22.68 mg/kg (4.5:1) at Isua, and 92.68 mg/kg against 21.65 mg/kg (4.3:1) at Iperindo/Imogbara/Odo Ijesa. The geo-accumulation index (Igeo) of heavy metal in the soil is significantly higher in degraded forestland. The high level of toxicants and contaminants present in the soil water is detrimental to crop yield and human food safety. The cyanidation that occurs in severely degraded areas for gold mining is characterized by low crop growth, yield, and the outcome being a high sensitivity to health challenges. However, if the threat continues unabated, many residents of Osun state would not be protected from a persistent outbreak of water-borne diseases.
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Abdallah, Mohammed, Ke Zhang, Lijun Chao, Abubaker Omer, Khalid Hassaballah, Kidane Welde Reda, Linxin Liu, Tolossa Lemma Tola, and Omar M. Nour. "A D-vine copula-based quantile regression towards merging satellite precipitation products over rugged topography: a case study in the upper Tekeze–Atbara Basin." Hydrology and Earth System Sciences 28, no. 5 (March 7, 2024): 1147–72. http://dx.doi.org/10.5194/hess-28-1147-2024.
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Abstract. Precipitation is a vital key element in various studies of hydrology, flood prediction, drought monitoring, and water resource management. The main challenge in conducting studies over remote regions with rugged topography is that weather stations are usually scarce and unevenly distributed. However, open-source satellite-based precipitation products (SPPs) with a suitable resolution provide alternative options in these data-scarce regions, which are typically associated with high uncertainty. To reduce the uncertainty of individual satellite products, we have proposed a D-vine copula-based quantile regression (DVQR) model to merge multiple SPPs with rain gauges (RGs). The DVQR model was employed during the 2001–2017 summer monsoon seasons and compared with two other quantile regression methods based on the multivariate linear (MLQR) and the Bayesian model averaging (BMAQ) techniques, respectively, and with two traditional merging methods – the simple modeling average (SMA) and the one-outlier-removed average (OORA) – using descriptive and categorical statistics. Four SPPs have been considered in this study, namely, Tropical Applications of Meteorology using SATellite (TAMSAT v3.1), the Climate Prediction Center MORPHing Product Climate Data Record (CMORPH-CDR), Global Precipitation Measurement (GPM) Integrated Multi-satellitE Retrievals for GPM (IMERG v06), and Precipitation Estimation from Remotely Sensed Information using Artificial Neural Networks (PERSIANN-CDR). The bilinear (BIL) interpolation technique was applied to downscale SPPs from a coarse to a fine spatial resolution (1 km). The rugged-topography region of the upper Tekeze–Atbara Basin (UTAB) in Ethiopia was selected as the study area. The results indicate that the precipitation data estimates with the DVQR, MLQR, and BMAQ models and with traditional merging methods outperform the downscaled SPPs. Monthly evaluations reveal that all products perform better in July and September than in June and August due to precipitation variability. The DVQR, MLQR, and BMAQ models exhibit higher accuracy than the traditional merging methods over the UTAB. The DVQR model substantially improved all of the statistical metrics (CC = 0.80, NSE = 0.615, KGE = 0.785, MAE = 1.97 mm d−1, RMSE = 2.86 mm d−1, and PBIAS = 0.96 %) considered compared with the BMAQ and MLQR models. However, the DVQR model did not outperform the BMAQ and MLQR models with respect to the probability of detection (POD) and false-alarm ratio (FAR), although it had the best frequency bias index (FBI) and critical success index (CSI) among all of the employed models. Overall, the newly proposed merging approach improves the quality of SPPs and demonstrates the value of the proposed DVQR model in merging multiple SPPs over regions with rugged topography such as the UTAB.
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Sahni, Bindu. "Socio- Religious Dichotomy among the Gujjars of Himachal Pradesh." IRA-International Journal of Management & Social Sciences (ISSN 2455-2267) 4, no. 2 (September 7, 2016): 387. http://dx.doi.org/10.21013/jmss.v4.n2.p8.
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<p><em>The Gujjars are primarily a pastoral tribe. They possess huge herds of buffaloes and in search of better grazing grounds they are constantly on the move. In Himachal Pradesh Gujjars are bracketed as a Scheduled Tribe<strong>. </strong>As per the Census of 2011, 5.7% population of Himachal Pradesh falls in the category of Scheduled Tribe. Though Gujjars are scattered all over Himachal Pradesh, their major concentrations are in Bilaspur, Chamba, Kangra and Una districts. Presently, Gujjars in Himachal Pradesh are nomad, semi-nomad and settled. Gujjars of Chamba and Kangra lead nomadic life, in Una and Bilaspur regions they are permanent settlers. Nomad Gujjars are those who keep on wandering from one place to another in search of grazing facilities. Nomad Gujjars always roam and shuttle between the higher and the lower hills in search of grazing tracts. Nomad Gujjars are known as Heer Gujjars in Una and Bilaspur and in Chamba and Kangra they are recognized as Ban Gujjars. The semi nomad Gujjars, though have permanent places of stay, they leave that for short periods in winters when the year faced scarcity of grazing grounds and return back in summers; after spending the winter in the rich grazing tracts; to their permanent residence in summers. Gujjars of Kangra lead a semi-nomadic life. Lyall mentions these semi- nomadic Gujjars of Kangra as Sawana Gujjars, who followed fixed grazing route i.e. in spite of being constantly on the move they follow the fixed tract every year and used to stay in the same huts where they stayed last year.<a title="" href="file:///C:/Users/SPub/Desktop/IRA%20August%20Issue%202016/IRAJMSS/IRAJMSS8.docx#_ftn1">[1]</a> Presently also these Gujjars are known as Sawana Gujjars. Settled Gujjars are those Gujjars who did not move any in search of grazing facilities, instead possess their own lands and grazing tracts and lead a settled life. These Gujjars have their permanent houses. Gujjars in Una and Bilaspur lead a settled life. Melveill, the first settlement officer of Una, confirms their settlements in Una as early as 1860s.<a title="" href="file:///C:/Users/SPub/Desktop/IRA%20August%20Issue%202016/IRAJMSS/IRAJMSS8.docx#_ftn2">[2]</a> However, in spite of leading diverse lifestyles one common thing between these nomad and settled Gujjars is that they all keep huge herds of buffaloes. Nomad (Ban) and semi nomad (Sawana) Gujjars in Himachal Pradesh are all Muslim by religion while settled Gujjars are largely Hindu; though a few among them are Muslim. <strong></strong></em></p><div><br clear="all" /><hr align="left" size="1" width="33%" /><div><p><em><a title="" href="file:///C:/Users/SPub/Desktop/IRA%20August%20Issue%202016/IRAJMSS/IRAJMSS8.docx#_ftnref1">[1]</a> Lyall, J.B., Report of the Land Revenue Settlement of the Kangra District, Panjab, 1867-72, Lahore: Central Jail Press, 1874,</em></p><p><em> p. 55.</em></p><p><em> </em></p></div><div><p><em><a title="" href="file:///C:/Users/SPub/Desktop/IRA%20August%20Issue%202016/IRAJMSS/IRAJMSS8.docx#_ftnref2">[2]</a> Melveill, P.S., Report of the Revised Settlement of the Oonah, Hushiarpur, Gurshunkur and Hurriana Purganahs of the </em></p><p><em> Hushiarpur District, Lahor: Punjab Press, 1860, p. 4</em></p></div></div>
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Árnason, Úlfur. "The unidirectional phylogeny of Homo sapiens anchors the origin of modern humans in Eurasia." Hereditas 158, no. 1 (September 14, 2021). http://dx.doi.org/10.1186/s41065-021-00197-7.
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Abstract Background The Out of Africa hypothesis, OOAH, was challenged recently in an extended mtDNA analysis, PPA (Progressive Phylogenetic Analysis), that identified the African human populations as paraphyletic, a finding that contradicted the common OOAH understanding that Hss had originated in Africa and invaded Eurasia from there. The results were consistent with the molecular Out of Eurasia hypothesis, OOEH, and Eurasian palaeontology, a subject that has been largely disregarded in the discussion of OOAH. Results In the present study the mtDNA tree, a phylogeny based on maternal inheritance, was compared to the nuclear DNA tree of the paternally transmitted Y-chromosome haplotypes, Y-DNAs. The comparison showed full phylogenetic coherence between these two separate sets of data. The results were consistent with potentially four translocations of modern humans from Eurasia into Africa, the earliest taking place ≈ 250,000 years before present, YBP. The results were in accordance with the postulates behind OOEH at the same time as they lent no support to the OOAH. Conclusions The conformity between the mtDNA and Y-DNA phylogenies of Hss is consistent with the understanding that Eurasia was the donor and not the receiver in human evolution. The evolutionary problems related to OOAH became similarly exposed by the mtDNA introgression that took place from Hss into Neanderthals ≈ 500,000 YBP, a circumstance that demonstrated the early coexistence of the two lineages in Eurasia.
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Árnason, Úlfur, and Björn Hallström. "The reversal of human phylogeny: Homo left Africa as erectus, came back as sapiens sapiens." Hereditas 157, no. 1 (December 2020). http://dx.doi.org/10.1186/s41065-020-00163-9.
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Abstract Background The molecular out of Africa hypothesis, OOAH, has been considered as an established fact amid population geneticists for some 25–30 years despite the early concern with it among phylogeneticists with experience beyond that of Homo. The palaeontological support for the hypothesis is also questionable, a circumstance that in the light of expanding Eurasian palaeontological knowledge has become accentuated through the last decades. Results The direction of evolution in the phylogenetic tree of modern humans (Homo sapiens sapiens, Hss) was established inter alia by applying progressive phylogenetic analysis to an mtDNA sampling that included a Eurasian, Lund, and the African Mbuti, San and Yoruba. The examination identified the African populations as paraphyletic, thereby compromising the OOAH. The finding, which was consistent with the out of Eurasia hypothesis, OOEH, was corroborated by the mtDNA introgression from Hss into Hsnn (Neanderthals) that demonstrated the temporal and physical Eurasian coexistence of the two lineages. The results are consistent with the palaeontologically established presence of H. erectus in Eurasia, a Eurasian divergence between H. sapiens and H. antecessor ≈ 850,000 YBP, an Hs divergence between Hss and Hsn (Neanderthals + Denisovans) ≈ 800,000 YBP, an mtDNA introgression from Hss into Hsnn* ≈ 500,000 YBP and an Eurasian divergence among the ancestors of extant Hss ≈ 250,000 YBP at the exodus of Mbuti/San into Africa. Conclusions The present study showed that Eurasia was not the receiver but the donor in Hss evolution. The findings that Homo left Africa as erectus and returned as sapiens sapiens constitute a change in the understanding of Hs evolution to one that conforms to the extensive Eurasian record of Hs palaeontology and archaeology.
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"Effects of ooral nicotine on P50 auditory sensory gating in nongating first-degree relatives of schizophrenic patients." Biological Psychiatry 31, no. 5 (March 1992): 71–72. http://dx.doi.org/10.1016/0006-3223(92)90376-b.
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P, Carolin, Kesavarajan S, Sudha Revathy S, and Mariappan A. "In Vitro Anti-Ulcer Activity Of Vempam Poo (Flower Of Azadirachta Indica) Ooral Kudineer – Siddha Herbal Drug." Educational Administration Theory and Practices, May 13, 2024. http://dx.doi.org/10.53555/kuey.v30i5.4097.
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Xu, Chun, Keping Zhou, Xin Xiong, and Yan Lu. "An Object-Oriented Approach for the Recursive Numeration and Visualization of the Key Strata of Coal Mines." Frontiers in Earth Science 9 (November 4, 2021). http://dx.doi.org/10.3389/feart.2021.717177.
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The exploitation and utilization of coal resources have caused serious ecological and environmental problems that are closely related to the movement and destruction of the overlying strata, especially the activities of the overlying key strata (KS). The existing KS calculation methods are characterized by low efficiency and high costs. This study proposes an object-oriented improved recursive algorithm (OORA) model to achieve efficient calculations for KS. An application program was developed and tested with the KS of the Xiadian coal mine, Shanxi, China. The calculation results were basically consistent with field observations, and the calculation depth was increased by 146.05 m. In addition, five typical KS calculation cases were selected for in-depth testing. The calculation time ranged from 0.175–0.225 s, and the calculation time was shortened by approximately three times compared to that with traditional methods. Therefore, it is feasible to apply the model algorithm for KS calculations, and the model provides benefits such as high efficiency and low costs.
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Torres, Lizeth Andrea Torres, Gabriel Silva, Jovelina Samara Ferreira Alves, Tatiane Resende Ushida, Julia Potenza, Cristiana Bernadelli Garcia, Lucas Oliveira Sousa, Norberto Peporine Lopes, Luciana Oliveira Almeida, and Andréia Machado Leopoldino. "FTY720 increases paclitaxel efficacy in cisplatin‐resistant oral squamous cell carcinoma." Journal of Oral Pathology & Medicine, November 9, 2023. http://dx.doi.org/10.1111/jop.13498.
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AbstractBackgroundOral squamous cell carcinoma has high recurrence and cisplatin resistance. As cancer stem cells, autophagy, and sphingolipids have been appointed as associated with chemotherapy resistance, we tested combined treatments targeting autophagy and/or sphingolipid metabolism with paclitaxel using cisplatin‐resistant oral squamous cell carcinoma cells.MethodsCisplatin‐resistant oral squamous cell carcinoma cells were maintained under exposition to FTY720 and chloroquine combined with paclitaxel and submitted to viability, clonogenicity, and spheres formation assays. The xenograft tumor model using cisplatin‐resistant CAL27 cells was adopted to examine the drug combinations' potential antitumoral efficacy. Using an animal model, sphingolipids profiles from plasma and tissue samples were obtained by liquid chromatography coupled to mass spectrometry to identify potential lipids associated with drug response.Results and DiscussionOur results showed higher autophagic flux in cisplatin‐resistant Ooral squamous cell carcinoma (CAL27 and SCC9) cells than in parental cells. The combinations of an autophagy inhibitor (chloroquine) or an autophagy inducer/sphingosine kinase 1 antagonist (FTY720) with paclitaxel (PTX) had a synergistic antitumor effect. Treated CisR cells lost clonogenicity and tumor sphere abilities and reduced proteins associated with proliferation, survival, and cancer stem cells. FTY720 plus PTX had higher antitumor efficacy than PTX against CAL27 CisR xenograft tumor formation. Additionally, increases in glucosylceramide, dehydroglucosylceramide, and sphingomyelin were presented in responsive tumors.ConclusionFTY720 sensitizes cisplatin‐resistant oral squamous cell carcinoma cells for paclitaxel.
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Jefferson, Charles W., Robert H. Rainbird, Grant M. Young, Joseph C. White, Victoria Tschirhart, and Robert A. Creaser. "The Paleoproterozoic Amer supergroup, Amer Fold Belt, Nunavut: stratigraphy, structure, correlations and uranium metallogeny." Canadian Journal of Earth Sciences, November 21, 2022. http://dx.doi.org/10.1139/cjes-2022-0077.
Full textAbstract:
The Amer Belt, hosting eleven informal formations of the Amer supergroup, is proposed as type area for four regional Paleoproterozoic sequences (Ps1-Ps4) in central Rae Craton, western Churchill Province. The ca. 1.9-1.865 Ga Snowbird orogeny (DP1) affected only Ps1-Ps3, whereas the ca. 1.87-1.81 Ga Hudsonian orogeny (DP2) affected all four. Sequence Ps1 Ayagaq Lake formation (<2.3 Ga quartzite) initiates as schistose basal polymict orthoconglomerate unconformably overlying paleoweathered Neoarchean rocks. It transitions upward to lower Ps2 Resort Lake formation: gossanous, recessive, graphitic, pyritic-metalliferous phyllite (Re-Os age 2126 ± 24 Ma). Ps2 conductors beneath the <1.74 Ga Thelon Formation have been drilled for unconformity-related uranium. Gradationally overlying siliceous dolomitic marble (Aluminium River formation) completes Ps2. The gradationally overlying lower Ps3 is either foliated calcareous tholeiitic basalt (Five Mile Lake formation) or grey phyllite (Three Lakes formation). These lateral equivalents host strong linear aeromagnetic markers. The Oora Lake formation foliated feldspathic calcareous sandstone gradationally overlies only the Three Lakes formation and underlies the upper Ps3 Showing Lake formation (interbedded phyllite and foliated calcareous arkose) whose two arkose members host laterally continuous disseminated uraninite + magnetite forming linear aeromagnetic markers. Pristine sequence Ps4 molasse, deposited and later deformed during DP2, comprises four formations of rhythmically interbedded, deep maroon to pink and green, feldspathic-lithic arenite, conglomerate and mudstone that unconformably overlie and include clasts of DP1-deformed Ps1 – Ps3 + Neoarchean basement. Ps4 detrital zircon (3.05 to 1.90 Ga) suggest local + distal provenance from south Rae and Slave cratons, and Taltson-Thelon magmatic zone.