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1

Overfield, Mike L., and Lisa C. Symons. "The Use of the RUST Database to Inventory, Monitor, and Assess Risk from Undersea Threats." Marine Technology Society Journal 43, no. 4 (October 1, 2009): 33–40. http://dx.doi.org/10.4031/mtsj.43.4.9.

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AbstractThe mission of the National Oceanic and Atmospheric Administration’s Office of National Marine Sanctuaries (ONMS) is to serve as the trustee for the nation’s system of marine protected areas, to conserve, protect, and enhance their biodiversity, ecological integrity, and cultural legacy. A century of ocean dumping has left the world with a forgotten legacy of chemical and conventional weapons, nuclear waste dumpsites, shipwrecks, abandoned pipelines, and wellheads found in all ocean waters, including those of the National Marine Sanctuary System. The ONMS created the Resources and Undersea Threats (RUST) database to catalogue potential threats, including shipwrecks, munitions dumpsites, radiological waste dumpsites, abandoned pipelines, and wellheads. RUST data are composed of and synthesized from numerous databases and thousands of document files that cover the U.S. coastline out to the outer continental shelf; however, initial database population has primarily focused on the NMS System. These data sources combine to create a single, all-inclusive entry for each submerged site that includes but is not limited to positioning, site type (i.e., vessel or munitions dumpsite), ship/container typology, cargo, type and estimated amount of hazardous material remaining (e.g., oil, diesel fuel, mustard gas), and inherent risks associated with the site. Taking a proactive instead of a reactive approach to mitigating this risk will reduce response costs and diminish the threat of environmental and socioeconomic damages.
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Morozov, A. D., and K. E. Morozov. "Global Dynamics of Systems Close to Hamiltonian Ones Under Nonconservative Quasi-periodic Perturbation." Nelineinaya Dinamika 15, no. 2 (2019): 187–98. http://dx.doi.org/10.20537/nd190208.

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Uozumi, Yoichi, Masaaki Taniguchi, Tomoaki Nakai, Hidehito Kimura, Toru Umehara, and Eiji Kohmura. "Comparative Evaluation of 3-Dimensional High Definition and 2-Dimensional 4-K Ultra-High Definition Endoscopy Systems in Endonasal Skull Base Surgery." Operative Neurosurgery 19, no. 3 (January 20, 2020): 281–87. http://dx.doi.org/10.1093/ons/opz426.

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Abstract BACKGROUND The differences between 3-dimensional (3D) high definition (HD) and 2-dimensional (2D) 4-K ultra-HD (4K) endoscopy and their respective advantages remain unclear. OBJECTIVE To evaluate the utility of these endoscopy systems in endonasal skull base surgery. METHODS Consecutive series of endoscopic endonasal surgeries performed after introduction of 3D/HD and 2D/4K systems (July 2017) were retrospectively evaluated. Sporadic cases treated with either system, or a conventional 2D standard definition (SD) system, during the rental period from March 2016 were also included. Objective comparisons between the systems were made for newly diagnosed Knosp grade 0 to 3 pituitary adenomas. Surgical procedures were divided into nasal, sphenoidal, and intradural phases, and the surgical procedural time was compared for each phase. The time required for and accuracy of suturing the sellar floor dura was also evaluated. RESULTS A total of 74 cases were treated with 3D/HD and/or 2D/4K, and 12 cases with 2D/SD. 3D/HD was advantageous in the nasal phase because of its intuitive depth perception. 2D/4K was advantageous in the intradural phase because of its superior image quality. Surgical time of the nasal phase with 3D/HD, and that of the intradural phase with 2D/4K, were significantly shorter than that with 2D/SD. The time required for and accuracy of sellar floor dural suturing showed a trend toward improving in the order of 2D/SD, 2D/4K, and 3D/HD. CONCLUSION 3D/HD and 2D/4K endoscopy systems have different advantages, which are useful in distinct surgical phases. Understanding the characteristics of endoscopy systems is important for selecting the most appropriate system for distinct surgical situations.
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Bezrukov, V. N., A. V. Balobanov, and V. G. Balobanov. "ONM system coding and decoding device for digital video data stream compression." Infokommunikacionnye tehnologii 13, no. 2 (June 2015): 190–96. http://dx.doi.org/10.18469/ikt.2015.13.2.12.

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Momeni, Davood, Phongpichit Channuie, and Mudhahir Al Ajmi. "Mapping of non-autonomous dynamical systems to autonomous ones." International Journal of Geometric Methods in Modern Physics 16, no. 06 (June 2019): 1950089. http://dx.doi.org/10.1142/s0219887819500890.

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Using a proper choice of the dynamical variables, we show that a non-autonomous dynamical system transforming to an autonomous dynamical system with a certain coordinate transformations can be obtained by solving a general nonlinear first-order partial differential equations. We examine some special cases and provide particular physical examples. Our framework constitutes general machineries in investigating other non-autonomous dynamical systems.
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Durán Santomil, Pablo, José Manuel Maside Sanfíz, Sara Cantorna Agra, and David Rodeiro Pazos. "¿Es el nuevo sistema de evaluación del EEES realmente diferente del sistema tradicional?: Un análisis empírico del rendimiento académico en una asignatura de contabilidad." EDUCADE - Revista de Educación en Contabilidad, Finanzas y Administración de Empresas, no. 4 (2013): 77–96. http://dx.doi.org/10.12795/educade.2013.i04.06.

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McGovern, Robert A., Soha Alomar, William E. Bingaman, and Jorge Gonzalez-Martinez. "Robot-Assisted Responsive Neurostimulator System Placement in Medically Intractable Epilepsy: Instrumentation and Technique." Operative Neurosurgery 16, no. 4 (May 23, 2018): 455–64. http://dx.doi.org/10.1093/ons/opy112.

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Abstract BACKGROUND The management of medically refractory epilepsy patients who are not surgical candidates has remained challenging. Closed loop—or responsive—neurostimulation (RNS) is now an established therapy for the treatment of epilepsy with specific indications. The RNS® system (NeuroPace Inc, Mountainview, California) has recently been shown to be effective in reducing the seizure frequency of partial onset seizures. The electrode design consists of either intracerebral depth electrodes or subdural strip electrodes, and stereotaxis is typically used to guide placement into the EZ. Details on the operative techniques used to place these electrodes have been lacking. OBJECTIVE To address the advantage of using a robotic-assisted technique to place depth electrodes for RNS® system placement compared to the typical frame-based or frameless stereotactic systems. METHODS We retrospectively reviewed our single center, technical operative experience with RNS® system placement using robotic assistance from 2014 to 2016 via chart review. RESULTS Twelve patients underwent RNS® system placement using robotic assistance. Mean operative time was 121 min for a median of 2 depth electrodes with mean deviation from intended target of ∼3 mm in x, y, and z planes. Two patients developed wound infections, 1 of whom was reimplanted. Seizures were reduced by ∼40% at 2 yr, similar to the results seen in the open label portion of the pivotal RNS trial. CONCLUSION Robotic-assisted stereotaxis can be used to provide a stable and accurate stereotactic platform for insertion of intracerebral RNS electrodes, representing a safe, efficient and accurate procedure.
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Hameed, N. U. Farrukh, Zehao Zhao, Jie Zhang, Linghao Bu, Yuyao Zhou, Lei Jin, Hongmin Bai, et al. "A Novel Intraoperative Brain Mapping Integrated Task-Presentation Platform." Operative Neurosurgery 20, no. 5 (February 6, 2021): 477–83. http://dx.doi.org/10.1093/ons/opaa476.

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Abstract BACKGROUND To be efficient, intraoperative task-presentation systems must accurately present various language and cognitive tasks to patients undergoing awake surgery, and record behavioral data without compromising convenience of surgery. OBJECTIVE To present an integrated brain mapping task-presentation system we developed and evaluate its effectiveness in intraoperative task presentation. METHODS The Brain Mapping Interactive Stimulation System (Brain MISS) is a flexible task presentation system that adjusts for patient comfort, needs of the surgeon, and operating team, with multivideo recording for patients’ behavior. A total of 48 patients from 3 centers underwent intraoperative language task test during awake brain surgery with the Brain MISS. Each patient was assigned 5 questions each on picture naming, reading, and listening comprehension before and during awake surgeries. The accuracy of intraoperative stimulus-response (without electrical stimulation) was recorded. The Brain MISS was to be considered effective, if the lower limit of 95% CI of patients’ intraoperative response was ≥80% and also if the accuracy of intraoperative response of all patients was statistically higher than 80%. RESULTS All patients successfully underwent intraoperative assessment with the Brain MISS. The overall accuracy of stimulus response was 95.8% (95% CI 90.18%-100.00%), with the lower limit being higher than 80% and the response accuracy also significantly being higher than 80% in all patients (P = .006). CONCLUSION The Brain MISS is a portable and effective system for presenting and streamlining complicated language and cognitive tasks during awake surgery. It can also record standardized patient response data for neuroscientific research.
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Murad, Dina Fitria, Widya Ratnasari, Bhumyamka Yala Saputra, and Bambang Dwi Wijanarko. "Warehouse Management System for Smart Digital Order Picking Systems." IJNMT (International Journal of New Media Technology) 6, no. 2 (January 16, 2020): 74–80. http://dx.doi.org/10.31937/ijnmt.v6i2.1215.

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The purpose of this paper is to identify problems in the identified picking process that lead to consumer dissatisfaction and provide solutions to problems that exist in the company, especially in warehousing, supported by analysis of the running system to obtain the information needed. The decision-making system is used to be able to produce information regarding picking orders in adjusting the number of orders, availability of pickers and distribution to consumers. The research method that uses the PIECES analysis and technology acceptance model method to determine the user's acceptance of the system being built. The smart digital order picking system was able to significantly accelerate the order picking business process from the ones that previously took a long time after implementation could meet consumer needs quickly.
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Asmaro, Karam, Jacob Pawloski, and Jesse Skoch. "Giant Choroid Plexus Papilloma Resection Utilizing a Transcollation System." Operative Neurosurgery 18, no. 1 (May 7, 2019): 47–51. http://dx.doi.org/10.1093/ons/opz096.

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Abstract BACKGROUND Large vascular brain tumors pose an exceptional challenge in young children. Choroid plexus papilloma (CPP) is an example of a rare, often large and especially vascular neuroepithelial tumor that most commonly arises in children under 5 yr old. Although patients may be cured by total resection, this tumor poses significant surgical risks and challenges related to intraoperative hemostasis. OBJECTIVE To describe our experience using a transcollation system during brain tumor surgery in a child to achieve hemostasis and minimize blood loss while preserving normal brain tissue. METHODS A 3-yr-old girl presented following a fall and was found to have a giant CPP growing from the right lateral ventricle. Given the vascularity of the tumor and the low intravascular reserve in a small child, a transcollation device was used to reduce blood loss intraoperatively. RESULTS Gross total resection was achieved with approximately 300 mL of blood loss without complications. The patient did well postoperatively. Imaging performed at 3 mo after resection revealed return of normal brain architecture. CONCLUSION Transcollation devices appear to be an effective and safe addition to the armamentarium of neurosurgical hemostatic options in intracranial tumor resection in which there is a high risk of intraoperative hemorrhage.
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Keeble, Hannah, José Pedro Lavrador, Noémia Pereira, Kornelius Lente, Christian Brogna, Richard Gullan, Ranjeev Bhangoo, Francesco Vergani, and Keyoumars Ashkan. "Electromagnetic Navigation Systems and Intraoperative Neuromonitoring: Reliability and Feasibility Study." Operative Neurosurgery 20, no. 4 (January 12, 2021): 373–82. http://dx.doi.org/10.1093/ons/opaa407.

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Abstract BACKGROUND A recent influx of intraoperative technology is being used in neurosurgery, but few reports investigate the accuracy and safety of these technologies when used simultaneously. OBJECTIVE To assess the ability to use an electromagnetic navigation system alongside multimodal intraoperative neurophysiological monitoring (IONM). METHODS Single-institution prospective cohort study of patients requiring craniotomy for brain tumor resection operated using an electromagnetic navigation system (AxiEM, Medtronic®). motor evoked potentials, somatosensory evoked potentials (SSEPs), electroencephalography, and electromyography were recorded and analyzed with AxiEM on (with/without filters) and off. The neurological outcomes of the patients were recorded. RESULTS A total of 15 patients were included (8 males/7 females, mean age 52.13 yr). Even though the raw acquisition is affected by the electromagnetic field (particularly SSEPs), no significant difference was detected in the morphology, amplitude, and latency of the different monitoring modalities (AxiEM off vs on) after the appropriate software filter application. Adjustments to the frequency of SSEP stimulation and number of averages, and reductions to the low-pass filters were applied. Notch filters were used appropriately and changes to the physical setup of the IONM and electromagnetic navigation system equipment reduced noise. Postoperatively, none of the patients developed new focal deficits; 7 patients showed improvement in their motor deficit (4 recovered fully). CONCLUSION The information provided by the IONM in intracranial neurosurgery patients whilst also using electromagnetic navigation systems is reliable for monitoring, mapping, and detecting intraoperative complications, provided that the appropriate software filters and tools are applied.
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Zasche, Petr. "Eclipsing Binaries Within Visual Ones: Prospects of Combined Solution." Proceedings of the International Astronomical Union 7, S282 (July 2011): 207–8. http://dx.doi.org/10.1017/s1743921311027384.

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AbstractThe study of eclipsing binaries as members of multiple systems can provide us important information about their origin, evolution, mutual inclination of the orbits, independent distance and mass determination, as well as the stellar multiplicity in general. We are carrying out a long-term photometric monitoring of several eclipsing binaries within the visual multiples and, besides the complete light curves, we are trying to detect the period changes due to the orbital motion around a common barycenter.Systems like DN UMa, V819 Her, LO Hya, or VW Cep are typical examples of eclipsing binaries orbiting around the barycenter of the multiple system, while their respective periods are on the order of years or decades. However, the expected period variation is only hardly detectable and there is still uncertainty about which of the components is the eclipsing one. Precise spectroscopy would be of great benefit, but detecting the changes in the gamma velocity is still problematic, and spectral disentangling of such complicated systems like sextuple VV Crv (periods 1.46, 3.14, and 44.51 days) is also rather difficult. However, the detection of the changing depths of the eclipses in the latter system would be interesting.
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Hendricks, Benjamin K., Jerome Hartman, and Aaron A. Cohen-Gadol. "Cerebrovascular Operative Anatomy: An Immersive 3D and Virtual Reality Description." Operative Neurosurgery 15, no. 6 (November 15, 2018): 613–23. http://dx.doi.org/10.1093/ons/opy283.

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Abstract BACKGROUND The innate detail of the cerebrovasculature is a demonstration of the structural complexity exhibited within the nervous system and highlights the challenges intrinsic to surgically influencing this system. Bridging the knowledge gap between the 2-dimentional learning environment and the 3-dimensional (3D) clinical setting is a challenge requiring experience. Computer graphic technology provides an opportunity for the learner to step into a new era of learning via the use of interactive 3D models and virtual reality. OBJECTIVE To create virtually anatomically accurate cerebrovascular models with superior detail and visual appeal. METHODS High-resolution angiographic radiological studies were utilized to create virtual 3D models which were edited for anatomical accuracy and artistry post-processing. RESULTS We have created anatomically realistic and detailed 3D virtual models of the cerebrovascular structures including the arterial and venous systems. The relevant surgical anatomy of the bony and brain structures was also included. In addition, these models were used to illustrate the pathoanatomy of a deep vascular malformation to demonstrate the potential of this technology. These models allow user interactivity in the 3D environment for improved understanding of anatomical relationships. CONCLUSION Advances in computer graphics have invited a new era of education and experiential learning. The authors have created an immersive virtual 3D model of the cerebrovasculature to augment education, research, and clinical applications.
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Zwart, H., Y. Le Gorrec, and B. Maschke. "Building systems from simple hyperbolic ones." Systems & Control Letters 91 (May 2016): 1–6. http://dx.doi.org/10.1016/j.sysconle.2016.02.002.

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Fan, Xiaoyao, Maxwell S. Durtschi, Chen Li, Linton T. Evans, Songbai Ji, Sohail K. Mirza, and Keith D. Paulsen. "Hand-Held Stereovision System for Image Updating in Open Spine Surgery." Operative Neurosurgery 19, no. 4 (May 4, 2020): 461–70. http://dx.doi.org/10.1093/ons/opaa057.

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Abstract BACKGROUND Image guidance in open spinal surgery is compromised by changes in spinal alignment between preoperative images and surgical positioning. We evaluated registration of stereo-views of the surgical field to compensate for vertebral alignment changes. OBJECTIVE To assess accuracy and efficiency of an optically tracked hand-held stereovision (HHS) system to acquire images of the exposed spine during surgery. METHODS Standard midline posterior approach exposed L1 to L6 in 6 cadaver porcine spines. Fiducial markers were placed on each vertebra as “ground truth” locations. Spines were positioned supine with accentuated lordosis, and preoperative computed tomography (pCT) was acquired. Spines were re-positioned in a neutral prone posture, and locations of fiducials were acquired with a tracked stylus. Intraoperative stereovision (iSV) images were acquired and 3-dimensional (3D) surfaces of the exposed spine were reconstructed. HHS accuracy was assessed in terms of distances between reconstructed fiducial marker locations and their tracked counterparts. Level-wise registrations aligned pCT with iSV to account for changes in spine posture. Accuracy of updated computed tomography (uCT) was assessed using fiducial markers and other landmarks. RESULTS Acquisition time for each image pair was <1 s. Mean reconstruction time was <1 s for each image pair using batch processing, and mean accuracy was 1.2 ± 0.6 mm across 6 cases. Mean errors of uCT were 3.1 ± 0.7 and 2.0 ± 0.5 mm on the dorsal and ventral sides, respectively. CONCLUSION Results suggest that a portable HHS system offers potential to acquire accurate image data from the surgical field to facilitate surgical navigation during open spine surgery.
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Tran, Diem Kieu, Michelle Paff, Lilit Mnatsakanyan, Indranil Sen-Gupta, Jack J. Lin, Frank P. K. Hsu, and Sumeet Vadera. "A Novel Robotic-Assisted Technique to Implant the Responsive Neurostimulation System." Operative Neurosurgery 18, no. 6 (September 19, 2019): 728–35. http://dx.doi.org/10.1093/ons/opz226.

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Abstract BACKGROUND The responsive neurostimulation system (RNS) (NeuroPace Inc, Mountain View, California) was approved as an adjunctive therapy for medically refractory focal epilepsy. RNS detects epileptiform patterns and delivers electrical stimulation to abort seizures. OBJECTIVE To describe a novel technique of RNS lead implantation using robotic-assisted targeting of ictal-onset zones based on stereoelectroencephalography (sEEG) localization. Secondary objectives are to report the accuracy of robotic-assisted lead implantation using the ROSA robot as well as to report the clinical outcome achieved after RNS implantation by this method. METHODS A total of 16 patients with medically refractory focal epilepsy underwent sEEG implantation for ictal-onset localization followed by robotic RNS implantation. The electrode most correlative with ictal onset on sEEG was chosen as the target for the RNS electrode. Seizure control was measured at 6-mo and 1-yr follow-up. Ictal-onset electrocorticography (ECoG) data from RNS were compared with ictal onset from sEEG leads based on calculations of lead target to actual lead location from the ROSA robot. RESULTS At 6-mo follow-up, the average percent seizure reduction was 82% based upon self-reported seizure diaries. At 1-yr follow-up, 8 patients had an average of 90% seizure reduction. The location of seizure onset from ECoG data show similar onset from sEEG leads within 0.165-mm discrepancy. CONCLUSION The ROSA robot provides an ideal method for targeting subcortical ictal-onset zones. This method of RNS lead implantation achieves high accuracy and is associated with favorable clinical outcomes.
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Liang, Allison S., Elizabeth E. Ginalis, Raja Jani, Eric L. Hargreaves, and Shabbar F. Danish. "Frameless Robotic-Assisted Deep Brain Stimulation With the Mazor Renaissance System." Operative Neurosurgery 22, no. 3 (December 31, 2021): 158–64. http://dx.doi.org/10.1227/ons.0000000000000050.

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Murai, Yasuo, Eitaro Ishisaka, Atsushi Tsukiyama, Shunsuke Nakagawa, Fumihiro Matano, Kojiro Tateyama, and Akio Morita. "Reuse of a Reversed “Bone Pad” to Perforate Incompletely Penetrated Burr Holes Created by Automatic-Releasing Cranial Perforators." Operative Neurosurgery 13, no. 3 (February 27, 2017): 324–28. http://dx.doi.org/10.1093/ons/opw043.

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Abstract BACKGROUND: It can be difficult to make complete burr holes using a perforator with automatic releasing systems in cases of a soft diploe or thick calvarial bone. OBJECTIVE: To demonstrate the utility of a flipped “bone pad” (BP) in recovery of penetration failure when using an automatic releasing perforator. METHODS: For craniotomy or ventricular drainage, the first step is to make 1 or more burr holes using a craniotome. Neurosurgeons sometimes incompletely penetrate the skull using the latest tools. As a countermeasure for such cases, we have developed a simple and practical method. When making a perforation using a high-speed perforator, a round bone piece we call the BP is formed just above the dura. We pulled the BP from a completed burr hole, and placed the reversed BP in position at the bottom of the incompletely perforated burr hole. The BP acted as a new hard surface, preventing the automatic releasing system from activating, and allowed the burr hole to be completed by the craniotome without the need for additional tools. RESULTS: With this technique, we have successfully completed 6 out of 7 imperfectly perforated burr holes using a perforator with an automatic releasing system. There were no technique-related complications, such as plunging or dural laceration. CONCLUSIONS: The method has the advantage that the BP can be obtained without drilling an additional burr hole, and can be completed without the need for increasing cost, time, or instrument usage.
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Malizia, Alessio, Pablo Acuna, Teresa Onorati, Paloma Diaz, and Ignacio Aedo. "CAP-ONES: an emergency notification system for all." International Journal of Emergency Management 6, no. 3/4 (2009): 302. http://dx.doi.org/10.1504/ijem.2009.031568.

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Koike, Tsukasa, Taichi Kin, Shota Tanaka, Katsuya Sato, Tatsuya Uchida, Yasuhiro Takeda, Hiroki Uchikawa, et al. "Development of a New Image-Guided Neuronavigation System: Mixed-Reality Projection Mapping Is Accurate and Feasible." Operative Neurosurgery 21, no. 6 (October 11, 2021): 549–57. http://dx.doi.org/10.1093/ons/opab353.

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Abstract BACKGROUND Image-guided systems improve the safety, functional outcome, and overall survival of neurosurgery but require extensive equipment. OBJECTIVE To develop an image-guided surgery system that combines the brain surface photographic texture (BSP-T) captured during surgery with 3-dimensional computer graphics (3DCG) using projection mapping. METHODS Patients who underwent initial surgery with brain tumors were prospectively enrolled. The texture of the 3DCG (3DCG-T) was obtained from 3DCG under similar conditions as those when capturing the brain surface photographs. The position and orientation at the time of 3DCG-T acquisition were used as the reference. The correct position and orientation of the BSP-T were obtained by aligning the BSP-T with the 3DCG-T using normalized mutual information. The BSP-T was combined with and displayed on the 3DCG using projection mapping. This mixed-reality projection mapping (MRPM) was used prospectively in 15 patients (mean age 46.6 yr, 6 males). The difference between the centerlines of surface blood vessels on the BSP-T and 3DCG constituted the target registration error (TRE) and was measured in 16 fields of the craniotomy area. We also measured the time required for image processing. RESULTS The TRE was measured at 158 locations in the 15 patients, with an average of 1.19 ± 0.14 mm (mean ± standard error). The average image processing time was 16.58 min. CONCLUSION Our MRPM method does not require extensive equipment while presenting information of patients’ anatomy together with medical images in the same coordinate system. It has the potential to improve patient safety.
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Sack, Jayson, Jeffrey A. Steinberg, Robert C. Rennert, Dustin Hatefi, Jeffrey S. Pannell, Michael Levy, and Alexander A. Khalessi. "Initial Experience Using a High-Definition 3-Dimensional Exoscope System for Microneurosurgery." Operative Neurosurgery 14, no. 4 (June 29, 2017): 395–401. http://dx.doi.org/10.1093/ons/opx145.

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Abstract BACKGROUND The operative microscope and endoscope have significantly advanced modern neurosurgery. These devices are nonetheless limited by high costs and suboptimal optics, ergonomics, and maneuverability. A recently developed extracorporeal telescope (“exoscope”) operative system combines characteristics from both the operative microscope and endoscope and provides an affordable, portable, high-definition operative experience. Widespread use of exoscopes in neurosurgery has previously been limited by a lack of stereopsis with 2-dimensional(2-D) monitors. OBJECTIVE To assess the surgical potential of a novel, 3-D, high-definition (4K-HD) exoscope system. METHODS Assess dissection time and visualization of critical structures in a series of human cadaveric cranial neurosurgical approaches with the 3-D 4K-HD exoscope as compared to a standard operating microscope. RESULTS Dissection times and visualization of critical structures was comparable with the 3-D 4K-HD exoscope and a standard operating microscope. The low-profile exoscope nonetheless allowed for larger operative corridors, enhanced instrument maneuverability, and less obstruction in passing instrumentation. The large monitor also resulted in an immersive surgical experience, and gave multiple team members the same high-quality view as the primary operator. Finally, the exoscope possessed a more ergonomically favorable setup as compared to the traditional microscope, allowing the surgeon to be in a neutral position despite the operative angle. CONCLUSION The novel 3-D 4K-HD exoscope system possesses favorable optics, ergonomics, and maneuverability as compared to the traditional operating microscope, with the exoscope's shared surgical view possessing obvious educational and workflow advantages. Further clinical trials are justified to validate this initial cadaveric experience.
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Guinto, Gerardo, Eli Hernández, Eric Estrada, David Gallardo, Miguel Kageyama, Norma Aréchiga, and Gerardo Y. Guinto-Nishimura. "Petroclival Meningiomas: A Simple System That Could Help in Selecting the Approach." Operative Neurosurgery 21, no. 4 (July 22, 2021): 225–34. http://dx.doi.org/10.1093/ons/opab224.

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Abstract BACKGROUND Petroclival meningiomas (PCM) represent a neurosurgical challenge due to their strategic location close to the brainstem. OBJECTIVE To assess the applicability of a retrosigmoid approach (RSA) by analyzing the degree of displacement of the middle cerebellar peduncle (MCP) elicited by PCM. METHODS Patients with PCM were prospectively included and divided into those whose imaging studies showed that the posterior end of the MCP was displaced by the tumor and were eligible for and underwent RSA (group A) and those who were not eligible for RSA and who underwent surgery via a posterior transpetrosal approach (group B). We compared tumor behavior, clinical characteristic of patients and surgical results. RESULTS Twenty patients with PCM were enrolled and allocated to group A (n = 15) or group B (n = 5). The clinical manifestations were more severe in group B; tumors in this group were larger and gross total removal was achieved in only 1 patient (20%). In comparison, in 12 cases on group A, tumors could be totally removed (80%) and all of these patients could recover their quality of life after surgery. CONCLUSION To our knowledge, this study is the first to consider displacement of the MCP when establishing a suitable surgical approach for PCM. Our results suggest that the RSA becomes increasingly suitable when peduncle displacement is greater. By using this method, it was also possible to identify two types of tumors: petroclivals (group A) and clivopetrosals (group B), that show some specific clinical and surgical differences.
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Kobak, L., O. Abrahamovych, U. Abrahamovych, and V. Chemes. "Modern View on the Problem of Systemic Lupus Erythematosus with and without Comorbid Lesions of the Circulatory System (Literature Review, Clinical Case Description) (first notice)." Lviv clinical bulletin 1-2, no. 33-34 (June 30, 2021): 37–50. http://dx.doi.org/10.25040/lkv2021.01-02.037.

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Context. The prevalence and incidence of systemic lupus erythematosus (SLE) in the world is significant. In recent years, there has been a tendency of the SLE prevalence increase. despite the undoubted progress in understanding the etiology and pathogenesis of SLE, its diagnosis and treatment, the mortality of patients, including ones at young and working age, is higher than in the general population, and circulatory system lesions are ones of its main reasons in these cases. Objective. To analyze the literature, dedicated to the modern view on the problem of systemic lupus erythematosus with and without comorbid lesions of the circulatory system, describe the clinical case. Materials and methods. Content analysis, method of system and comparative analysis, bibliosemantic method of studying the current scientific investigations on modern principles of diagnosis and treatment of patients with SLE are used. A clinical case is described. Results. The article presents modern ideas about the etiological factors and pathogenesis of the disease. The clinical manifestations of SLE are very diverse. The problem of comorbidity and syntropy of lesions is relevant. Lesions of the cardiovascular system in the case of SLE can manifest itself in the form of pericarditis, myocarditis, endocarditis, lesions of the heart valves, coronary arteries, aorta, conduction system, pulmonary hypertension occurrence. The basic principles of drug therapy are also briefly considered. Conclusions. The results of the literature review indicate the importance of the problem of systemic lupus erythematosus, due to its widespread prevalence among the young and people of working age, lack of accurate knowledge about the etiology and pathogenesis of the disease, comorbid lesions of many organs and systems, including circulatory system, the development of severe and often life-threatening manifestations, the lack of clear recommendations that would predict the differentiated use of drugs taking into account comorbid syntropic lesions, which is also demonstrated in the described clinical case. Given this, systemic lupus erythematosus needs further in-depth study.
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Tan, Lee A., and Ronald A. Lehman. "Robotic-Assisted Spine Surgery Using the Mazor XTM System: 2-Dimensional Operative Video." Operative Neurosurgery 16, no. 4 (August 7, 2018): E123. http://dx.doi.org/10.1093/ons/opy200.

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Abstract We demonstrate the setup and workflow of performing robotic spine surgery using the Mazor XTM system (MAZOR Robotics Inc, Orlando, Florida) in this video. An illustrative case was presented, including detailed steps for S2AI screw and lumbar pedicle screw placement using robotic assistance. A step-by-step narration is provided along with discussion of surgical nuances. Robotic spine surgery can be a safe and efficient method for screw placement, which can potentially reduce the risk of screw malposition. Spine surgeons should be familiar with this technology and keep this technique in their armamentarium. There is no identifying information in this video. A patient consent was obtained for publishing of the material included in the video.
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Driver, Joseph, John K. Dorman, and John H. Chi. "A Novel Mobile Device-Based Navigation System for Placement of Posterior Spinal Fixation." Operative Neurosurgery 22, no. 4 (February 11, 2022): 249–54. http://dx.doi.org/10.1227/ons.0000000000000116.

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Sharchenaliev, Zh, and N. Tsybov. "System Analysis Enhancement in Cognitive Learning Systems Engineering." Bulletin of Science and Practice 6, no. 1 (January 15, 2020): 226–36. http://dx.doi.org/10.33619/2414-2948/50/25.

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Improving the efficiency of the use of cognitive learning systems in education directly depends on the ability of the system to make reasonable decisions in the formation of didactic tools. One of the methods to improve the efficiency of functioning of cognitive learning systems is to improve the functioning algorithm of system analysis. Improving the individual components of system analysis has expanded its functionality and qualitatively changed its options. Using the advantages of the advanced functionality of system analysis enabled us to develop a cognitive learning system that forms didactic tools considering the psycho-factors of the participants of educational process. The goal of the article is to study methods for designing and expanding the functional capacities of cognitive learning systems and system analysis methods. Methodological basis is formed of comprehensive application of complementary approaches in which the system analysis considers the educational environment as a complex system containing interconnected subsystems. The main ones of them were the structural analysis method, comparison method, decomposition and aggregation method. Results. Improving the efficiency of use of the cognitive learning system and increasing its accuracy in the analysis of the educational situation while choosing pedagogical methods for teaching the educational material was achieved by improving the functionality of system analysis. Improving the accuracy of the implementation of system analysis was also achieved through the use of ‘fuzzy elements’ in the analysis and synthesis node of the cognitive learning system. The use of ‘fuzzy elements’ enabled the learning system to make corrections to the input data received at the beginning of task execution and to give adjusted administration commands to the algorithm correction node of the system analysis.
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WANG, YAN-WU, ZHI-HONG GUAN, HUA O. WANG, and JIANG-WEN XIAO. "IMPULSIVE CONTROL FOR T–S FUZZY SYSTEM AND ITS APPLICATION TO CHAOTIC SYSTEMS." International Journal of Bifurcation and Chaos 16, no. 08 (August 2006): 2417–23. http://dx.doi.org/10.1142/s0218127406016161.

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An impulsive T–S fuzzy model is presented in this paper. The stability of impulsive controlled T–S fuzzy system has been analyzed theoretically. The proposed impulsive control scheme seems to have a simple control structure and may need less control energy than the normal continuous ones for the stabilization of T–S fuzzy system. Some typical chaotic systems, such as Chua's circuit, Lorenz system and Chen's chaotic system, are considered as illustrations to demonstrate the effectiveness of the proposed control scheme.
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Wulandari, Arum Sekar, Aditya Wardani, and Nurheni Wijayanto. "Respon Fisiologi Mindi (Melia azedarach L.) dan Kedelai (Glycine max (L.) Merrill) dalam Agroforestri Secara Organik." Journal of Tropical Silviculture 11, no. 1 (April 27, 2020): 11–17. http://dx.doi.org/10.29244/j-siltrop.11.1.11-17.

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Mindi is one of commercial tree species for its timber. Sustainable management of mindi community forest can be obtained by inter-planting the trees with agricultural crop such as soybean. This study aimed to analyze physiological respond of mindi and soybean, which were planted in an organic agroforestry system. The research was done in Conservation Unit for Medicinal Plants at Cikabayan, Bogor Agricultural University (IPB). The first study was about the growth of mindi saplings in monoculture and agroforestry systems (with soybean). The experiment used completely randomized design (CRD). The second study was about the growth of soybean in monoculture and agroforestry systems (with mindi), and used split-plot design. The result show that nutrient uptake of N, P, and K in agroforestry system was higher than in monoculture. The increase of nutrient content in agroforestry system led to the higher increase of growth dimensions of mindi tree than the ones in monoculture. The content of soybean chlorophyll planted in agroforestry system was higher than the ones in monoculture. Soybean in agroforestry system had higher nutrient uptake of N, P, and K compared to the ones in monoculture. Soybean productivity in monoculture system showed higher result than the ones in agroforestry. Keywords: chlorophyll, monoculture, root, tree dimension, varieties
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Clotet, Josep, and M. Dolors Magret. "Upper Bounds for the Distance between a Controllable Switched Linear System and the Set of Uncontrollable Ones." Mathematical Problems in Engineering 2013 (2013): 1–9. http://dx.doi.org/10.1155/2013/948147.

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The set of controllable switched linear systems is an open and dense set in the space of all switched linear systems. Therefore it makes sense to compute the distance from a controllable system to the nearest uncontrollable one. In the case of a standard system,x˙t=Axt+But, R. Eising, D. Boley, and W. S. Lu obtain some results for this distance, both in the complex and real cases. In this work we explore this distance, for switched linear systems in the real case, obtaining upper bounds for it. The main contribution of the paper is to prove that a natural generalization of the upper bound obtained by D. Boley and W. S. Lu is true in the case of switched linear systems.
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Budke, Marcelo, Josue M. Avecillas-Chasin, and Francisco Villarejo. "Implantation of Depth Electrodes in Children Using VarioGuide® Frameless Navigation System: Technical Note." Operative Neurosurgery 15, no. 3 (September 9, 2017): 302–9. http://dx.doi.org/10.1093/ons/opx192.

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Abstract BACKGROUND Electrode placement in epilepsy surgery seeks to locate the sites of ictal onset and early propagation. An invasive diagnostic procedure, stereoelectroencephalography (SEEG) is usually implemented with frame-based methods that can be especially problematic in young children. OBJECTIVE To evaluate the feasibility and accuracy of a new technique for frameless SEEG in children using the VarioGuide® system (Brainlab AG, München, Germany). METHODS A frameless stereotactic navigation system was used to implant depth electrodes with percutaneous drilling and bolt insertion in pediatric patients with medically refractory epilepsy. Data on general demographic information of electrode implantation, duration, number, and complications were retrospectively collected. To determine the placement accuracy of the VarioGuide® frameless system, the mean Euclidean distances were calculated by comparing the preoperatively planned trajectories with the final electrode position observed on postoperative computed tomography scans. RESULTS From May 2011 to December 2015, 15 patients (8 males, 7 females; mean age: 8 yr, range: 3-16 yr) underwent SEEG depth electrode implantation of a total of 111 electrodes. The mean error measured by the Euclidean distance from the center of the entry point to the intended entry point was 3.64 ± 1.78 mm (range: 0.58-7.59 mm) and the tip of the electrode to the intended target was 2.96 ± 1.49 mm (range: 0.58-7.82 mm). There were no significant complications. CONCLUSION Depth electrodes can be placed safely and accurately in children using the VarioGuide® frameless stereotactic navigation system.
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Hamilton, Travis, and Victor Chang. "Commentary: A Novel Mobile-Device-Based Navigation System for Placement of Posterior Spinal Fixation." Operative Neurosurgery 22, no. 5 (March 22, 2022): e231-e232. http://dx.doi.org/10.1227/ons.0000000000000181.

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Ben Njima, Chakib, Walid Ben Mabrouk, Hassani Messaoud, and Germain Garcia. "Finite Time Stabilization of the Four Tanks System: Extensions to the Uncertain Systems." Abstract and Applied Analysis 2014 (2014): 1–7. http://dx.doi.org/10.1155/2014/964143.

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We consider the finite time stability and stabilization of linear systems described in continuous time. First, we provide a condition for the stability over time using the state transition matrix standard. Then we give conditions to design a state feedback control that stabilizes the system over time. In some cases where there is uncertainty in the system model, the previous conditions are extended to a certain class of uncertain systems. The considered uncertainties are the polytopic and norm bounded ones. To reveal the proposed approach, an application to the four tanks system was made.
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Rejabov, Zaylobitdin Mamatovich. "Dynamic Models Of An Electromechanical Electric Drive System Of An Asynchronous Motor." American Journal of Engineering And Techonology 03, no. 04 (April 30, 2021): 134–39. http://dx.doi.org/10.37547/tajet/volume03issue04-21.

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Asynchronous motors require its study not only in stationary modes, but also in dynamic ones. At the same time, this makes it possible to formulate the corresponding requirements for automatic control devices of a regulated IM, the implementation of which will ensure the optimal course of transient processes in the electric drive system; it requires its study not only in stationary modes, but also in dynamic ones. This simultaneously makes it possible to formulate the corresponding requirements for automatic control devices of variable IM, the implementation of which will ensure the optimal course of transient processes in the electric drive system The study of electromechanical transient modes requires a joint consideration and solution of the equations of equilibrium of electrical quantities in the windings of the machine and the equations of motion of an electric drive.
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Khalessi, Alexander A., Ralph Rahme, Robert C. Rennert, Pia Borgas, Jeffrey A. Steinberg, Timothy G. White, David R. Santiago-Dieppa, et al. "First-in-Man Clinical Experience Using a High-Definition 3-Dimensional Exoscope System for Microneurosurgery." Operative Neurosurgery 16, no. 6 (November 26, 2018): 717–25. http://dx.doi.org/10.1093/ons/opy320.

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ABSTRACT BACKGROUND During its development and preclinical assessment, a novel, 3-dimensional (3D), high-definition (4K-HD) exoscope system was formerly shown to provide an immersive surgical experience, while maintaining a portable, low-profile design. OBJECTIVE To assess the clinical applicability of this 3D 4K-HD exoscope via first-in-man surgical use. METHODS The operative workflow, functionality, and visual haptics of the 3D 4K-HD exoscope were assessed in a variety of microneurosurgical cases at 2 US centers. RESULTS Nineteen microneurosurgical procedures in 18 patients were performed exclusively using the 3D 4K-HD exoscope. Pathologies treated included 4 aneurysms, 3 cavernous malformations (1 with intraoperative electrocorticography), 2 arteriovenous malformations, 1 foramen magnum meningioma, 1 convexity meningioma, 1 glioma, 1 occipital cyst, 1 chiari malformation, 1 carotid endarterectomy, 1 subdural hematoma, 1 anterior cervical discectomy and fusion, and 2 lumbar laminectomies. All patients experienced good surgical and clinical outcomes. Similar to preclinical assessments, the 3D 4K-HD exoscope provided an immersive 3D surgical experience for the primary surgeon, assistants, and trainees. The small exoscope frame, large depth of field, and hand/foot pedal controls improved exoscope mobility, decreased need to re-focus, and provided unobstructed operative corridors. Flexible positioning of the camera allows the surgeon's posture to be kept in a neutral position with uncompromised viewing angles. CONCLUSION The first-in-man clinical experience with the 3D 4K-HD exoscope confirms its excellent optics and ergonomics for the entire operative team, with high workflow adaptability for a variety of microneurosurgical cases. Expanded clinical use of the 3D 4K-HD exoscope is justified.
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Goren, Oded, Christoph J. Griessenauer, Christian O. Bohan, Christopher M. Berry, and Clemens M. Schirmer. "Minimally Invasive Parafascicular Surgery for Resection of Cerebral Cavernous Malformations Utilizing Image-Guided BrainPath System." Operative Neurosurgery 17, no. 4 (December 19, 2018): 348–53. http://dx.doi.org/10.1093/ons/opy389.

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Abstract BACKGROUND The minimally invasive parafascicular approach provides a surgical corridor to reach deep lesions with minimal impact on the surrounding brain tissue. OBJECTIVE To evaluate the safety and efficacy of this approach utilizing the image-guided tubular BrainPath system (NICO Corp, Indianapolis, Indiana) for the resection of deep and subcortical supratentorial cerebral cavernous malformations (CCMs). METHODS We performed a retrospective analysis of patients who presented with subcortical CCMs treated with the BrainPath system. Patient demographics, clinical presentation, procedural complications, and clinical and imaging follow-up information were assessed. RESULTS Six patients were identified between December 2014 and November 2017 at a large volume academic institution in the United States. There were 3 males and 3 female patients with a median age of 25 yr. Locations included frontal, temporal, and parietal lobes. In selected cases, the fiber-sparing trajectory imposed a longer approach than the closest distance to the brain surface. Except for 1 patient who suffered from surgical wound dehiscence, there were no operative complications in any of the cases. All patients remained neurologically stable postoperatively with a mean follow-up of 20 moh. CONCLUSION This small series suggests that the use of a minimally invasive surgical approach to CCMs utilizing the image-guided parafascicular tubular BrainPath system is feasible, safe, and effective.
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Kostromina, O. S. "On two-frequency quasi-periodic perturbations of systems close to two-dimensional Hamiltonian ones with a double limit cycle." Vestnik Udmurtskogo Universiteta. Matematika. Mekhanika. Komp'yuternye Nauki 31, no. 1 (March 2021): 35–49. http://dx.doi.org/10.35634/vm210103.

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The problem of the effect of two-frequency quasi-periodic perturbations on systems close to arbitrary nonlinear two-dimensional Hamiltonian ones is studied in the case when the corresponding perturbed autonomous systems have a double limit cycle. Its solution is important both for the theory of synchronization of nonlinear oscillations and for the theory of bifurcations of dynamical systems. In the case of commensurability of the natural frequency of the unperturbed system with frequencies of quasi-periodic perturbation, resonance occurs. Averaged systems are derived that make it possible to ascertain the structure of the resonance zone, that is, to describe the behavior of solutions in the neighborhood of individual resonance levels. The study of these systems allows determining possible bifurcations arising when the resonance level deviates from the level of the unperturbed system, which generates a double limit cycle in a perturbed autonomous system. The theoretical results obtained are applied in the study of a two-frequency quasi-periodic perturbed pendulum-type equation and are illustrated by numerical computations.
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Tanaka, Keiji, Kazuho Ohara, Noriyuki Miyazaki, and Noboru Edagawa. "Performance analysis of Ethernet PON system accommodating 64 ONUs." Journal of Optical Networking 6, no. 5 (2007): 559. http://dx.doi.org/10.1364/jon.6.000559.

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Shkel, A. A., O. A. Mazhukina, and O. V. Fedotova. "Synthesis of thiopyranochromen-2-ones, a new heterocyclic system." Chemistry of Heterocyclic Compounds 47, no. 5 (August 2011): 656–58. http://dx.doi.org/10.1007/s10593-011-0816-y.

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Vrana, I. "How to approach the development of enterprise information system." Agricultural Economics (Zemědělská ekonomika) 50, No. 1 (February 24, 2012): 41–46. http://dx.doi.org/10.17221/5165-agricecon.

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Nowadays, many enterprises face  the problem of implementing their enterprise information system in order to keep pace with their competition. It holds generally for all types of enterprises, as e.g. manufacturing, agricultural, trading, financial, transportation, educational, etc. This paper deals with the basic rules for building an information system of the enterprise, particularly of medium or large  ones. The attention is focussed at the problems each enterprise must address before starting an IS project. These are mainly the enterprise information policy planning, project feasibility and forms of its management.
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Kobak, L., O. Abrahamovych, U. Abrahamovych, and V. Chemes. "Modern View on the Problem of Systemic Lupus Erythematosus with and without Comorbid Lesions of the Circulatory System (Literature Review, Clinical Case Description) – Second Notice." Lviv clinical bulletin 2-3, no. 35-36 (December 24, 2021): 65–69. http://dx.doi.org/10.25040/lkv2021.03-04.065.

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Introduction. The prevalence and incidence of systemic lupus erythematosus (SLE) in the world is significant. In recent years, there has been a tendency of the SLE prevalence increase. Despite the undoubted progress in understanding the etiology and pathogenesis of SLE, its diagnosis and treatment, the mortality of patients, including ones at young and working age, is higher than in the general population, and circulatory system lesions are ones of its main reasons in these cases. The aim of the study. To analyze the literature, devoted to the modern view on the problem of systemic lupus erythematosus with and without comorbid lesions of the circulatory system, describe the clinical case. Materials and methods. Content analysis, method of system and comparative analysis, bibliosemantic method of studying the current scientific studies on modern principles of diagnosis and treatment of patients with SLE are used. A clinical case is described. Results. A clinical case of a 43-year-old patient S., who was hospitalized for SLE, she considers herself ill for eighteen years and she has been constantly taken outpatient and periodically inpatient treatment due to the frequent deteriorations in her general condition, clinical and laboratory parameters, is described. Based on the received results of the examinations, applying the method of determining the functional class of SLE, the patient was diagnosed with a clinical diagnosis indicating comorbid lesions of various organs and systems (skin, joints, kidneys, vessels, heart, blood system, immune system, eyes). The generally accepted basic medical complex of the patient includes drugs, taking into account the lesions to the circulatory system. The conducted complex pathogenetic treatment gave a positive result. Conclusions. In the described clinical case demonstrated the development of comorbid lesions of many organs and systems, including circulatory system, in a patient with systemic lupus erythematosus. Inclusion in the treatment complex in addition to basic and drugs for the treatment lesions of circulatory system has improved the general condition of the patient, stabilized clinical and laboratory parameters, as evidenced by a prospective study during three years. The information provided in our clinical case is consistent with the results of the literature review. Systemic lupus erythematosus needs further in-depth study due to its widespread prevalence among young and people of working age, lack of accurate knowledge about the etiology and pathogenesis of the disease, comorbid lesions of many organs and systems, including circulatory system, the development of severe and often life-threatening manifestations, the lack of clear recommendations that would predict the differentiated use of drugs taking into account comorbid syntropic lesions. Keywords: SLE, circulatory system lesions, atherosclerosis, diagnosis and treatment of SLE.
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Philipp, Lucas R., Mark R. Witcher, and Robert E. Gross. "A Novel Approach for Responsive Neural Stimulator Implantation With Infraclavicular Placement of the Internal Pulse Generator." Operative Neurosurgery 15, no. 6 (March 14, 2018): 711–19. http://dx.doi.org/10.1093/ons/opy025.

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Abstract INTRODUCTION The Responsive Neurostimulation System (RNS, Neuropace, Mountain View, California) has been proven to be effective at reducing seizures in patients with partial-onset epilepsy. The system incorporates a skull-mounted neurostimulator that requires a cranial incision for replacement. Although integral to the functioning of the system, in some circumstances, such as in the setting of infection, this can be disadvantageous. At present, there are no alternatives to cranial implantation of the RNS System. METHODS We describe a novel procedure enabling implantation of the neurostimulator within the chest wall, using components from a peripheral nerve stimulator. In a patient who achieved complete seizure freedom with the use of the RNS System, distant site implantation provided a viable means of continuing therapy in a setting where device explantation would have otherwise been inevitable as a result of cranial infection. We present continuous electrocorticographic data recorded from the device documenting the performance of the system with the subclavicular neurostimulator. RESULTS Band pass detection rates increased by 50%, while line length detection rates decreased by 50%. The number of detections decreased from 1046 to 846, with a resultant decrease in stimulations. Although there was some compromise of function due to the elevated noise floor, more than 2 yr following the procedure the patient remains free of seizures and infection. CONCLUSION The salvage procedure we describe offered an alternative therapeutic option in a patient with a complicated cranial wound issue, using heterogeneous components with marginal compromises in device functionality and no sacrifice in patient outcome.
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Hou, Yang, Yanping Lin, Jiangang Shi, Huajiang Chen, and Wen Yuan. "Effectiveness of the Thoracic Pedicle Screw Placement Using the Virtual Surgical Training System: A Cadaver Study." Operative Neurosurgery 15, no. 6 (March 14, 2018): 677–85. http://dx.doi.org/10.1093/ons/opy030.

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Abstract BACKGROUND The virtual simulation surgery has initially exhibited its promising potentials in neurosurgery training. OBJECTIVE To evaluate effectiveness of the Virtual Surgical Training System (VSTS) on novice residents placing thoracic pedicle screws in a cadaver study. METHODS A total of 10 inexperienced residents participated in this study and were randomly assigned to 2 groups. The group using VSTS to learn thoracic pedicle screw fixation was the simulation training (ST) group and the group receiving an introductory teaching session was the control group. Ten fresh adult spine specimens including 6 males and 4 females with a mean age of 58.5 yr (range: 33-72) were collected and randomly allocated to the 2 groups. After exposing anatomic structures of thoracic spine, the bilateral pedicle screw placement of T6-T12 was performed on each cadaver specimen. The postoperative computed tomography scan was performed on each spine specimen, and experienced observers independently reviewed the placement of the pedicle screws to assess the incidence of pedicle breach. RESULTS The screw penetration rates of the ST group (7.14%) was significantly lower in comparison to the control group (30%, P < .05). Statistically significant difference in acceptable rates of screws also occurred between the ST (100%) and control (92.86%) group (P < .05). In addition, the average screw penetration distance in control group (2.37 mm ± 0.23 mm) was significantly greater than ST group (1.23 mm ± 0.56 mm, P < .05). CONCLUSION The virtual reality surgical training of thoracic pedicle screw instrumentation effectively improves surgical performance of novice residents compared to those with traditional teaching method, and can help new beginners to master the surgical technique within shortest period of time.
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Murai, Yasuo, Shun Sato, Kanako Yui, Daijiro Morimoto, Tomohiro Ozeki, Masahiro Yamaguchi, Kojiro Tateyama, et al. "Preliminary Clinical Microneurosurgical Experience With the 4K3-Dimensional Microvideoscope (ORBEYE) System for Microneurological Surgery: Observation Study." Operative Neurosurgery 16, no. 6 (December 3, 2018): 707–16. http://dx.doi.org/10.1093/ons/opy277.

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Abstract BACKGROUND The exoscope has been reported as a novel neurosurgical instrumentation in clinical practice. OBJECTIVE To investigate the possibility that ORBEYE (OE), a novel instrument that excludes eyepiece lenses and allows for microsurgery by observation of the 4K3D monitor, could replace microscopes. METHODS We report 22 clinical cases by 5 experienced neurosurgeons and the comparative results of training 10 residents. An observation study with questionnaire survey was conducted on usability. Twelve items including image quality, eyestrain, and function of the arm were evaluated. RESULTS The following 22 clinical procedures were conducted: surgery for intracranial hemorrhage (n = 2) and brain tumor (n = 8), laminectomy (n = 3), aneurysm clipping (n = 3), vascular anastomosis (n = 2), carotid endarterectomy (n = 2), and nerve decompression (n = 1). No complications were observed. The fluorescent study, including indocyanine-green and 5-aminolevunic acid, allowed for clear depiction on the 4K monitor. The surgeon could operate in a comfortable posture. Similar to the microscope, it was possible to change the optical and viewing axes with the OE, but the OE was switched to the microscope or endoscope in hematoma removal and pituitary surgery. Residents judged that eyestrain was strong (P = .0096). Experienced neurosurgeons acting as assistants judged that the scope arm's range of movement was narrow (P = .0204). Sixty percent of residents judged that the OE was superior to the microscope. CONCLUSION Although based on limited experience, it was not possible to substitute the microscope with the OE in all operations; however, the OE surpasses the microscope in terms of ergonomic features.
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Dawley, Troy, and Michael Schulder. "Commentary: First-In-Man Clinical Experience Using a High-Definition 3-Dimensional Exoscope System for Microneurosurgery." Operative Neurosurgery 16, no. 6 (November 28, 2018): E161—E162. http://dx.doi.org/10.1093/ons/opy363.

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Maragkos, Georgios A., and Ajith J. Thomas. "Commentary: Minimally Invasive Parafascicular Surgery for Resection of Cerebral Cavernous Malformations Utilizing Image-Guided BrainPath System." Operative Neurosurgery 17, no. 4 (March 15, 2019): E141—E142. http://dx.doi.org/10.1093/ons/opz033.

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Harput, Mehmet Volkan, and Uğur Türe. "Commentary: First-in-Man Clinical Experience Using a High-Definition 3-Dimensional Exoscope System for Microneurosurgery." Operative Neurosurgery 17, no. 2 (April 18, 2019): E85—E87. http://dx.doi.org/10.1093/ons/opz067.

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Pitskhelauri, David, Andrey Bykanov, Alexander Konovalov, Gleb Danilov, Svetlana Buklina, Alexander Sanikidze, and Rinat Sufianov. "Transsylvian Insular Glioma Surgery: New Classification System, Clinical Outcome in a Consecutive Series of 79 Cases." Operative Neurosurgery 20, no. 6 (March 2, 2021): 541–48. http://dx.doi.org/10.1093/ons/opab051.

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Abstract BACKGROUND Surgery of insular glial tumors remains a challenge because of high incidence of postoperative neurological deterioration and the complex anatomy of the insular region. OBJECTIVE To explore the prognostic role of our and Berger-Sanai classifications on the extent of resection (EOR) and clinical outcome. METHODS From 2012 to 2017, a transsylvian removal of insular glial tumors was performed in 79 patients. The EOR was assessed depending on magnetic resonance imaging scans performed in the first 48 h after surgery. RESULTS The EOR ≥90% was achieved in 30 (38%) cases and <90% in 49 (62.0%) cases. In the early postoperative period, the new neurological deficit was observed in 31 (39.2%) patients, and in 5 patients (6.3%), it persisted up to 3 mo. We proposed a classification of insular gliomas based on its volumetric and anatomical characteristics. A statistically significant differences were found between proposed classes in tumor volume before and after surgery (P < .001), EOR (P = .02), rate of epileptic seizures before the surgical treatment (P = .04), and the incidence of persistent postoperative complications (P = .03). In the logistic regression model, tumor location in zone II (Berger-Sanai classification) was the predictor significantly related to less likely EOR of ≥90% and the maximum rate of residual tumor detection (P = .02). CONCLUSION The proposed classification of the insular gliomas was an independent predictor of the EOR and persistent postoperative neurological deficit. According to Berger-Sanai classification, zone II was a predictor of less EOR through the transsylvian approach.
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Medina, Rogelio, Luke Macyszyn, Andrew S. Lim, Mark Attiah, Kayla Kafka-Peterson, Tania Kaprelian, John V. Hegde, et al. "High-Dose Rate Interstitial Spine Brachytherapy Using an Intraoperative Mobile Computed Tomography-Guided Surgical Navigation System." Operative Neurosurgery 21, no. 6 (October 20, 2021): 507–15. http://dx.doi.org/10.1093/ons/opab328.

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Abstract BACKGROUND Up to 15% of previously irradiated metastatic spine tumors will progress. Re-irradiation of these tumors poses a significant risk of exceeding the radiation tolerance to the spinal cord. High-dose rate (HDR) brachytherapy is a treatment alternative. OBJECTIVE To develop a novel HDR spine brachytherapy technique using an intraoperative computed tomography-guided navigation (iCT navigation). METHODS Patients with progressive metastatic spine tumors were included in the study. HDR brachytherapy catheters were placed under iCT navigation. CT-based planning with magnetic resonance imaging fusion was performed to ensure conformal dose delivery to the target while sparing normal tissue, including the spinal cord. Patients received single fraction radiation treatment. RESULTS Five patients with thoracolumbar tumors were treated with HDR brachytherapy. Four patients previously received radiotherapy to the same spinal level. Preimplant plans demonstrated median clinical target volume (CTV) D90 of 116.5% (110.8%-147.7%), V100 of 95.7% (95.5%-99.6%), and Dmax of 8.08 Gy (7.65-9.8 Gy) to the spinal cord/cauda equina. Postimplant plans provided median CTV D90 of 113.8% (93.6%-120.1%), V100 of 95.9% (87%-99%), and Dmax of 9.48 Gy (6.5-10.3 Gy) to cord/cauda equina. Patients who presented with back pain (n = 3) noted symptomatic improvement at a median follow-up of 22 d after treatment. Four patients demonstrated local tumor control of spinal metastatic tumor at a median follow-up of 92 d after treatment. One patient demonstrated radiographic evidence of local tumor progression 2.7 mo after treatment. CONCLUSION HDR spine brachytherapy with iCT navigation is a promising treatment alternative to induce local tumor control and reduce pain symptoms associated with metastatic spine disease.
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Li, Boyi, Michael G. Kim, Jose Dominguez, Eric Feldstein, George Kleinman, and Simon Hanft. "Intraventricular Choroid Plexus Cavernoma Resection Using Tubular Retractor System and Exoscope Visualization: A Technical Case Report." Operative Neurosurgery 22, no. 3 (January 14, 2022): e134-e137. http://dx.doi.org/10.1227/ons.0000000000000075.

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50

Legnani, Federico G., Andrea Franzini, Luca Mattei, Andrea Saladino, Cecilia Casali, Francesco Prada, Alessandro Perin, et al. "Image-Guided Biopsy of Intracranial Lesions with a Small Robotic Device (iSYS1): A Prospective, Exploratory Pilot Study." Operative Neurosurgery 17, no. 4 (January 23, 2019): 403–12. http://dx.doi.org/10.1093/ons/opy411.

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Abstract BACKGROUND Robotic technologies have been used in the neurosurgical operating rooms for the last 30 yr. They have been adopted for several stereotactic applications and, particularly, image-guided biopsy of intracranial lesions which are not amenable for open surgical resection. OBJECTIVE To assess feasibility, safety, accuracy, and diagnostic yield of robot-assisted frameless stereotactic brain biopsy with a recently introduced miniaturized device (iSYS1; Interventional Systems Medizintechnik GmbH, Kitzbühel, Austria), fixed to the Mayfield headholder by a jointed arm. METHODS Clinical and surgical data of all patients undergoing frameless stereotactic biopsies using the iSYS1 robotized system from October 2016 to December 2017 have been prospectively collected and analyzed. Facial surface registration has been adopted for optical neuronavigation. RESULTS Thirty-nine patients were included in the study. Neither mortality nor morbidity related to the surgical procedure performed with the robot was recorded. Diagnostic tissue samples were obtained in 38 out of 39 procedures (diagnostic yield per procedure was 97.4%). All patients received a definitive histological diagnosis. Mean target error was 1.06 mm (median 1 mm, range 0.1-4 mm). CONCLUSION The frameless robotic iSYS1-assisted biopsy technique was determined to be feasible, safe, and accurate procedure; moreover, the diagnostic yield was high. The surface matching registration method with computed tomography as the reference image set did not negatively affect the accuracy of the procedure.
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