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1
Wang, Yang-Kao, Hsi-Hui Lin, and Ming-Jer Tang. "Collagen gel overlay induces two phases of apoptosis in MDCK cells." American Journal of Physiology-Cell Physiology 280, no. 6 (June 1, 2001): C1440—C1448. http://dx.doi.org/10.1152/ajpcell.2001.280.6.c1440.
Abstract:
We previously demonstrated that collagen gel overlay induced cell remodeling to form lumen and apoptosis in Madin-Darby canine kidney cells. In the present study, we established that collagen gel overlay-induced apoptosis was initiated at areas exclusive of cell remodeling within 24 h (first phase) and extended into areas of cell remodeling within 48 h (second phase). Collagen gel overlay-induced apoptosis was accompanied by selective proteolysis of focal adhesion kinase (FAK), talin, p130cas, and c- src. Upon collagen gel overlay, FAK was initially degraded into a 90-kDa product during the first phase and subsequently into a 80-kDa product during the second phase. Collagen gel overlay-induced apoptosis of focal adhesion complex proteins and apoptosis of the first phase could be blocked only by a protease inhibitor cocktail. In addition, we found that both DEVD-fmk and ZVAD-fmk inhibited secondary proteolysis of FAK, but only ZVAD-fmk blocked collagen gel overlay-induced apoptosis of the second phase. Finally, collagen gel overlay-induced apoptosis and proteolysis of focal adhesion complex proteins were completely inhibited by the combination of protease inhibitor cocktail and ZVAD-fmk. Taken together, collagen gel overlay induces two phases of apoptosis; the first phase is dependent on proteolysis of focal adhesion complex proteins, and the second phase on activation of caspases.
2
Ann Drago, Dorothy, Carol Pollack-Nelson, and Sarah Beth Newens. "Infant fatality patterns in shared sleep: keys to intervention strategies?" Proceedings of the Human Factors and Ergonomics Society Annual Meeting 65, no. 1 (September 2021): 1322–26. http://dx.doi.org/10.1177/1071181321651174.
Abstract:
This study examines infant fatalities that occurred while sharing a sleep surface. Fatality data reported to the U.S. Consumer Product Safety Commission (CPSC) during the time period January, 2013 through December, 2017 and involving infants through age 10 months were reviewed. 1,587 Cases were analyzed on the following variables: infant age and sex; sleep environment by product; cause of death; fatality pattern; and breastfeeding, where it was mentioned. 97% Of deaths were due to some form of asphyxia. Adult beds were associated with 78% of shared sleep fatalities, and the primary fatality pattern was overlay (35.4%)/probable overlay (8.8%). Infants <3 months made up 65% of fatalities. The data reflect that bedsharing continues, despite AAP guidelines to the contrary, and that overlay is the primary hazard pattern to be addressed. This paper discusses potential risk reduction strategies that may reduce the potential for overlay fatalities.
3
Sattayawat, Pachara, Ian Sofian Yunus, and Patrik R. Jones. "Bioderivatization as a concept for renewable production of chemicals that are toxic or poorly soluble in the liquid phase." Proceedings of the National Academy of Sciences 117, no. 3 (January 8, 2020): 1404–13. http://dx.doi.org/10.1073/pnas.1914069117.
Abstract:
Bio-based production technologies may complement or replace petroleum-based production of chemicals, but they face a number of technical challenges, including product toxicity and/or water insolubility. Plants and microorganisms naturally biosynthesize chemicals that often are converted into derivatives with reduced toxicity or enhanced solubility. Inspired by this principle, we propose a bioderivatization strategy for biotechnological chemicals production, defined as purposeful biochemical derivatization of intended target molecules. As proof of principle, the effects of hydrophobic (e.g., esterification) and hydrophilic (e.g., glycosylation) bioderivatization strategies on the biosynthesis of a relatively toxic and poorly soluble chemical, 1-octanol, were evaluated in Escherichia coli and Synechocystis sp. PCC 6803. The 1-octanol pathway was first optimized to reach product titers at which the host displayed symptoms of toxicity. Solvent overlay used to capture volatile products partially masked product toxicity. Regardless of whether solvent overlay was used, most strains with bioderivatization had a higher molar product titer and product yield, as well as improved cellular growth and glucose consumption, compared with strains without bioderivatization. The positive effect on bioproduction was observed with both the hydrophobic and hydrophilic strategies. Interestingly, in several combinations of genotype/induction strength, bioderivatization had a positive effect on productivity without any apparent effect on growth. We attribute this to enhanced product solubility in the aqueous or solvent fraction of the bioreactor liquid phase (depending on the derivative and medium used), with consequent enhanced product removal. Overall, under most conditions, a benefit of bioproduction was observed, and the bioderivatization strategy could be considered for other similar chemicals as well.
4
HAH, ZOO-HWAN, HYUN-JUNG KIM, and SUNG-KIE YOUN. "A HIERARCHICALLY SUPERIMPOSING LOCAL REFINEMENT METHOD FOR ISOGEOMETRIC ANALYSIS." International Journal of Computational Methods 11, no. 05 (October 2014): 1350074. http://dx.doi.org/10.1142/s0219876213500746.
Abstract:
In isogeometric analysis, the tensor-product form of Nonuniform Rational B-spline (NURBS) represents spline surfaces. Due to the nature of the tensor-product, the local refinement in isogeometric analysis has many issues to be resolved. Attempts have been made in this regard, such as T-splines and hierarchical approaches. In this work, a local refinement method for isogeometric analysis based on a superimposing concept is proposed. Local refinements are performed by superimposing hierarchically-created finer overlay meshes onto the regions of high error rather than a change of analysis basis (from NURBS to some other spline space). To employ the superimposing concept as a local refinement strategy in isogeometric analysis, a hierarchical framework to construct overlay meshes is developed, and compatibility conditions across the interfacial boundaries of different levels of meshes is discussed. Through numerical examples, the effectiveness and validity of the proposed method are demonstrated.
5
Combrier, Emmanuel, and Dominique Castelli. "The Agarose Overlay Method as a Screening Approach for Ocular Irritancy: Application to Cosmetic Products." Alternatives to Laboratory Animals 20, no. 3 (July 1992): 438–44. http://dx.doi.org/10.1177/026119299202000310.
Abstract:
The in vitro agarose overlay method was investigated as an alternative to the Draize eye irritation test for the evaluation of the ocular irritancy of cosmetic products. Modifications to the original protocol include the definition of an area of lysis (expressed as a weighty)/toxicity relationship for each product by a planimetric method and the creation of an agarose classification. 56 different cosmetic formulations, including emulsions, gels, lotions and tonics, were evaluated using this modified test, and the results were correlated with in vivo Draize data. Four different agarose classes were delimited: non-irritant; minimally irritant; mildly irritant; and irritant; corresponding respectively to the following scoring scales (x 10 4g): 0; 0 <x<200; 200≤ x <450 and ≥ 450. A high correlation between the agarose overlay method and the Draize test was observed when taking into account two classes: non-irritant (non-irritant, minimally irritant) and irritant (mildly irritant, moderately irritant [Draize] or irritant [agarose]) as shown by an 86% concordance value. In this study, the sensitivity was 92% (11–12 irritants were predicted by the agarose diffusion method) and the specificity was 84%. The overestimation error of 16% suggests that the agarose overlay method might be slightly more sensitive than the Draize eye test. When applying the kappa test, the agarose overlay method reached a 64% coefficient, attesting that the good correlation with the Draize test was not due to chance. In relation to the Landis & Koch classification, this percentage places the agarose overlay method in the “good concordance” class. Based on these results, the use of the agarose overlay method for screening the ocular irritation potential for the cosmetics industry can be considered to be a very interesting alternative to be included in a battery of tests.
6
Hasanloo, M., P. Pahlavani, and B. Bigdeli. "FLOOD RISK ZONATION USING A MULTI-CRITERIA SPATIAL GROUP FUZZY-AHP DECISION MAKING AND FUZZY OVERLAY ANALYSIS." ISPRS - International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences XLII-4/W18 (October 18, 2019): 455–60. http://dx.doi.org/10.5194/isprs-archives-xlii-4-w18-455-2019.
Abstract:
Abstract. In this study, a GIS based approach has been proposed for the flood risk zonation based on a multi-criteria spatial group fuzzy AHP decision making analysis and its integration with fuzzy overlay analysis. For this purpose, 10 layers affecting flood occurrence have been used including: the Digital Elevation Model (DEM), Slope, NDVI, Flow Accumulation (Flow Ac.), HOFD, VOFD, Topographic Position Index (TPI), Topographic Wetness Index (TWI), Curve Number (CN), Modified Fournier Index. Each layer was classified into 5 sub-classes and their preference at its layer was weighted by a group of experts using fuzzy analytical hierarchy processes (GFAHP) method. Finally, the risk map of the studied area with the weight of experts and fuzzy overlay method was product and divided into five categories.
7
Shelton, Doug, Tomii Kume, Charles Wang, Alex Hubbard, Cody Murray, and Rob DeLancey. "Advanced Process Technology for 3D and 2.5D Applications." International Symposium on Microelectronics 2014, no. 1 (October 1, 2014): 000905–11. http://dx.doi.org/10.4071/isom-thp55.
Abstract:
Advanced process technology is required to develop and enable mass production of high-density 3D and 2.5D interconnect technologies. In this paper, Canon and IBM @ Albany NanoTech will present process optimization results for lithography applications requiring precise thick-resist profile control and precise overlay accuracy of distorted patterns on bonded process wafers. Canon will also provide additional product updates from Canon Anelva.
8
Pratama, Surya Adi, and Alla Asmara. "The Role of Leading Sectors in Supporting the Economic Growth of East Java Province Before and During the Covid-19 Pandemic." International Journal of Research and Review 10, no. 9 (September 15, 2023): 62–75. http://dx.doi.org/10.52403/ijrr.20230908.
Abstract:
East Java is one of the driving forces of Indonesia's economy as it is the second-largest contributor to the Gross Regional Domestic Product (PDRB) after DKI Jakarta. However, in 2020, the economy of East Java experienced a contraction with a growth rate reaching -2.33 percent. This was primarily due to the impact of the Covid-19 pandemic, which led to negative growth in several sectors. In order to achieve the objectives and targets of regional development, especially in terms of economic growth in East Java Province, regional development can be structured according to inter-sectoral goals. Through descriptive analysis, the Location Quotient (LQ) approach, the Shift Share approach, and overlay using the Real Gross Domestic Product (PDRB Rill) based on constant prices in 2010, four leading sectors were identified. These sectors are the manufacturing industry, wholesale and retail trade, motor vehicle and motorcycle repair, accommodation, and food services, as well as information and communication. These four leading sectors play a crucial role in supporting economic growth in East Java due to their rapid growth rate, high contribution, and broad market share, both before and during the Covid-19 pandemic. Hence, the government needs to prioritize these leading sectors to support economic growth in East Java Province. Keywords: Covid-19, Economic Growth, Gross Domestic Regional Product, Overlay, Location Quotient, Shift Share
9
Tita, Efrida, Slamet Santoso, Rochmat Aldy Purnomo, Asis Riat Winanto, and Choirul Hamidah. "ANALISIS DAYA SAING EKSPOR JASA NEGARA ASEAN." Bina Ekonomi 24, no. 1 (September 10, 2021): 71–86. http://dx.doi.org/10.26593/be.v24i1.5030.71-86.
Abstract:
This research aims to determine the export competitiveness of asean country's service sector’s. The data used to support this research is secondary data in the form of service sector export data, total exports, and Gross Domestic Product (GDP) Constant Price for the study period in 2015-2019. The analysis tools used are Klassen Typology, Location Quotient (LQ), Revealed Competitive Advantage (RCA), and Overlay analysis. Based on the results of overlay analysis by combining three analytical tools (Klassen Typology, LQ, and RCA), shows that the export competitiveness of the service sector owned by Singapore is insurance and pension services; charges for the use of intellectual property; telecommunications, computer, and information services; and other business services. Malaysia's export competitiveness of the service sector is personal, cultural, and recreational services, while the Philippines is telecommunications, computer, and information services. Meanwhile, Indonesia and Vietnam are ASEAN countries that do not have export-competitive service sectors.
10
Shrivastaw, Nilesh. "Augmented Reality-Based Product Video Promotion Application: A Framework and Implementation." International Journal for Research in Applied Science and Engineering Technology 12, no. 3 (March 31, 2024): 2500–2504. http://dx.doi.org/10.22214/ijraset.2024.59384.
Abstract:
Abstract: Augmented Reality (AR) technology has gained significant attention in recent years due to its potential to enhance user experiences across various domains. In the realm of marketing and promotion, AR presents a promising avenue for engaging consumers in immersive product experiences. This paper proposes a framework and implementation of a product video promotion application leveraging augmented reality technology. The application aims to revolutionize traditional product promotion strategies by providing users with interactive and immersive experiences through AR-enhanced product videos. The proposed system integrates computer vision, 3D modelling, and AR rendering techniques to overlay virtual product information seamlessly onto the real-world environment captured through a smartphone or tablet camera. Additionally, the application incorporates features such as real-time product visualization, interactive product demonstrations, and social sharing functionalities to enhance user engagement and promote viral marketing. Through a comprehensive review of related works and the presentation of our framework and implementation details, this paper contributes to the growing body of research on ARbased marketing solutions and provides insights into the potential of AR technology for transforming product promotion strategies.
11
Oloton, Enosakhare, and Emmanuel Obaseki. "Quantitative assessment of available probiotic products in community pharmacies in Benin City, Nigeria." Tropical Journal of Pharmaceutical Research 19, no. 7 (November 18, 2020): 1511–17. http://dx.doi.org/10.4314/tjpr.v19i7.25.
Abstract:
Purpose: To assess four probiotic products available in community pharmacies in Benin City, Nigeria for accuracy of information on product labels with regard to the quantity and type of microorganisms, pH and bile tolerance, and antimicrobial activity.Methods: Percent label compliance of products was determined, in addition to isolation, identification and enumeration of microorganisms. Determination of pH and bile tolerance was conducted using turbidity studies in MRS broth. Antimicrobial activity against Pseudomonas aeruginosa, Escherichia coli, Bacillus subtilis, Klebsiella pneumonia, Staphylococcus aureus and Candida albicans pathogens was investigated using agar overlay technique.Results: In each product, there was 100 % label compliance with regard to name of probiotic organism, storage condition, dose, expiration date, contact details and batch number. Three-quarters (75 %) of the probiotic products indicated product net quantity, National Agency for Food and Drug Administration and Control (NAFDAC) number, and microbial count; 50 % of products indicated the excipients used, while only 25 % of the products showed their indications. None of the products indicated strain designation. In species identification, Enterococcus faecium was absent in a multi-species product PB1, while PB3 contained Saccharomyces cerevisiae instead of Saccharomyces boulardii. Enumeration showed comparatively low quantities of probiotic organisms. Tolerance to pH 3 and pH 7, and bile levels of 0.3 and 2 % were within acceptable range. The probiotic organisms demonstrated antimicrobial effect specifically against P. aeruginosa, E. coli, B. subtilis, K. pneumonia, S. aureus and C. albicans.Conclusion: Antimicrobial effect and tolerance to pH and bile salts were consistent with acceptable properties of probiotics. However, there is need for total compliance with the indications, strain designation, excipients, and actual quantity of the individual probiotic organisms in the formulations.
Keywords: Probiotics, Strain designation, Agar overlay technique, Saccharomyces cerevisiae, Saccharomyces boulardii
12
Pilipović, Ana, Tomaž Brajlih, and Igor Drstvenšek. "Influence of Processing Parameters on Tensile Properties of SLS Polymer Product." Polymers 10, no. 11 (October 31, 2018): 1208. http://dx.doi.org/10.3390/polym10111208.
Abstract:
Polymer products manufactured by additive processes are today increasingly flooding the market. Given that they have broad application ranging from various consumer products to medicine and automotive industry, the products must satisfy certain mechanical properties. In the past studies of selective laser sintering (SLS) for polymer materials, the processing parameter of energy density has been confirmed which affects the tensile properties. Energy density depends on the laser beam speed, laser power and hatch distance; however, in this paper the existing mathematical model has been expanded by the overlay ratio and tests have been conducted how on the basis of the new mathematical model a product with good tensile properties (tensile strength, tensile strength at break, tensile modulus, tensile strain at break) can be manufactured. However, in parameter selection as well, the layer thickness and the manufacturing strategy also play a role, and they may shorten the time and reduce the cost necessary to manufacture a new product from the initial concept to production. The paper also provides a proposal of processing parameters (laser beam speed, laser power and energy density) depending on the manufacturing strategy and layer thickness.
13
Schoemaker, Paul J. H., Sohvi Heaton, and David Teece. "Innovation, Dynamic Capabilities, and Leadership." California Management Review 61, no. 1 (August 1, 2018): 15–42. http://dx.doi.org/10.1177/0008125618790246.
Abstract:
The world in which today’s businesses operate has become not only riskier but also more volatile, uncertain, complex, and ambiguous (VUCA). Organizations that hew too closely to traditional ways of operating will be hampered in their ability to succeed. In contrast, those that focus on new product and process developments coupled with business model innovation will leverage their dynamic capabilities. An essential overlay is entrepreneurial leadership from top management teams. Strong dynamic capabilities are impossible without it. This article examines how business model innovations, dynamic capabilities, and strategic leadership intertwine to help organizations thrive in VUCA worlds.
14
Al Wakil, Anmar. "WHEN GAMBLING IS NOT WINNING: EXPLORING OPTIMALITY OF VIX TRADING UNDER THE EXPECTED UTILITY THEORY." Journal of Business Accounting and Finance Perspectives 1, no. 1 (August 26, 2019): 1. http://dx.doi.org/10.26870/jbafp.2018.01.004.
Abstract:
Recently, financial innovations have given rise to complex derivatives within the asset management industry. Although traditional assets pay dividends or coupons, vIX futures contracts have been partly misunderstood by unsophisticated investors, as they only provide portfolio insurance against stock market crashes. Therefore, over the calmer period 2009-2014, the most traded vIX futures exchange-traded product lost practically all of its value, ruining unexperienced investors. hence, this paper investigates appropriateness of these complex derivatives with investor's risk aversion. We address portfolio-choice optimality under uncertainty, for overlay allocations composed of equities, bonds, and vIX futures. This paper proposes a non-trivial solution based on the expected utility theory to simulate investor's behavior with risk aversion. Furthermore, it derives an investor's surprise metric defined as a welfare criterion measure, and a modelimplied risk premium defined as the insurance premium investor pays ex post to hedge. Empirical results show investing in vIX futures significantly beats traditionally diversified portfolios, but they turn to be particularly inappropriate for risk-loving investors. From the asset management perspective, this paper has practical implications since it recommends pedagogical efforts to raise investors' awareness of overlay strategies.
15
Hongrattanavorakit, Sakarin, and Sukunya Chantakul. "Product design of Sukhothai fabric woven Lampshade from Origami techniques." Asian Journal of Arts and Culture 21, no. 2 (December 27, 2021): 8–14. http://dx.doi.org/10.48048/ajac.2021.248654.
Abstract:
Research on Product design of Sukhothai fabric woven Lampshade from Origami techniques is to study consumer satisfaction with the product. The researcher has defined and design sketch of the fabric pattern on one lampshade for five expertise to choose the most suitable design for Sukhothai fabric woven Lampshade from Origami techniques. Then we did a satisfaction survey for the satisfaction level from 50 persons of the target group, The collected data were analyzed using frequency, percentage and mean with the following analysis results.The survey found that by patterning the fabric horizontally will make the lamp bigger and gives relaxation feel, and the six-petaled origami fold is appropriate because it’s resembles a lotus flower which is the province flower of Sukhothai, The decoration styled is group overlay, suitable because the natural composition. The satisfaction of sample consumer towards the prototype product, The average score of 4.10 toward the design and composition of the pattern is related, The average score of 4.36 which is at the highest level for the lampshade is convenient to use and in term of usability and the product suitable for sale the average score is at 4.16
16
Pilipović, Ana, Igor Drstvenšek, and Mladen Šercer. "Mathematical Model for the Selection of Processing Parameters in Selective Laser Sintering of Polymer Products." Advances in Mechanical Engineering 6 (January 1, 2014): 648562. http://dx.doi.org/10.1155/2014/648562.
Abstract:
Additive manufacturing (AM) is increasingly applied in the development projects from the initial idea to the finished product. The reasons are multiple, but what should be emphasised is the possibility of relatively rapid manufacturing of the products of complicated geometry based on the computer 3D model of the product. There are numerous limitations primarily in the number of available materials and their properties, which may be quite different from the properties of the material of the finished product. Therefore, it is necessary to know the properties of the product materials. In AM procedures the mechanical properties of materials are affected by the manufacturing procedure and the production parameters. During SLS procedures it is possible to adjust various manufacturing parameters which are used to influence the improvement of various mechanical and other properties of the products. The paper sets a new mathematical model to determine the influence of individual manufacturing parameters on the polymer product made by selective laser sintering. Old mathematical model is checked by statistical method with central composite plan and it is established that old mathematical model must be expanded with new parameter beam overlay ratio. Verification of new mathematical model and optimization of the processing parameters are made on SLS machine.
17
Bause, Melania, Bahar Khayamian Esfahani, Hannah Forbes, and Dirk Schaefer. "Design for Health 4.0: Exploration of a New Area." Proceedings of the Design Society: International Conference on Engineering Design 1, no. 1 (July 2019): 887–96. http://dx.doi.org/10.1017/dsi.2019.93.
Abstract:
AbstractDriven by networked Electronic Health Record systems, Artificial Intelligence, real-time data from wearable devices with an overlay of invisible user interfaces and improved analytics, Health 4.0 is changing the healthcare industry. The focus on collaboration, coherence, and convergence that will make healthcare more predictive and personalised. Furthermore, Health 4.0 realises the value of data more consistently and effectively. It can pinpoint areas of improvement and enable more informed decisions. What it also does is help move the entire healthcare industry from a system that is reactive and focused on fee-for-service to a system that is value-based, which measures outcomes and ensures proactive prevention.In this paper, the authors will first explore the realm of the emerging area of Health 4.0 and identify its opportunities and challenges. This includes understanding the relevant base technologies as well as the design principles for the realization of smart healthcare product, systems and product-service-systems of the future. Following on from there, the authors focus on the role of design in the specific context of healthcare.
18
Pingki, Anadiya, Bambang Sumantri, and Ketut Sukiyono. "Analysis of Economic Structure and Leading Sectors in Rejang Lebong District." AGRITROPICA : Journal of Agricultural Sciences 4, no. 1 (May 31, 2021): 8–19. http://dx.doi.org/10.31186/j.agritropica.4.1.8-19.
Abstract:
This study aims to determine and analyze the economic structure and leading sectors in Rejang Lebong Regency. The data used is secondary data on Gross Regional Domestic Product from 2015 to 2019 obtained from the Central Statistics Agency. The analysis used is economy structure, Location Quotient (LQ), Dynamic Location Quotient (DLQ), Shift-share, and Overlay. The results show that the highest GRDP contributor is the Agriculture, Fisheries, and Forestry sectors while the lowest is the Electricity and Gas Procurement sector with contribution of 32% and 0.15% respectively. The results of the leading economic sectors in the Rejang Lebong Regency are the sectors of Agriculture, Forestry and Fisheries, Providing Accommodation and Food and Drink; Defense and Compulsory Social Security; Education Services; Health Services and Other Services.
19
Tanovic, Brankica, Slavica Gasic, Jovana Hrustic, Milica Mihajlovic, Mila Grahovac, Goran Delibasic, and Marija Stevanovic. "Development of a thyme essential oil formulation and its effect on Monilinia ructigena." Pesticidi i fitomedicina 28, no. 4 (2013): 273–80. http://dx.doi.org/10.2298/pif1304273t.
Abstract:
Antifungal activity of thyme essential oil against Monilinia fructigena and development of an effective and stable oil formulation for agricultural use were studied in this paper. Bioactivity of the oil itself and its developed formulation, an emulsifiable concentrate (EC), was tested in vitro and in vivo. In vitro experiments, using a slightly modified agar overlay technique, showed that the initially emulsified thyme essential oil, as well as the developed formulation, significantly inhibited mycelial growth of M. fructigena in vitro. Experiments in vivo, performed on inoculated apple fruits, revealed that the formulation successfully decreased oil evaporation from the treated area and provided a significant level of M. fructigena suppression, 64.7-72.1% compared to the control. To our knowledge, an EC formulation of thyme essential oil for agricultural uses had never been developed before. The presented results are initial findings and evaluation of product activity should be continued in the field to determine its efficacy and activity spectrum, and to estimate the economic aspect of its use.
20
Rusmala, Iga. "Identification of the Puting Beliung Event by Utilizing the Interpretations of Radar Products and Himawari-8 Weather Satellite (Case Study: Puting Beliung Incident, November 22, 2018 in Jakarta)." Jurnal Meteorologi dan Geofisika 23, no. 3 (June 14, 2022): 15. http://dx.doi.org/10.31172/jmg.v23i3.799.
Abstract:
<em>Indonesia was shocked again by a Puting beliung or tornado-like incident on November 22, 2018, in the Jakarta area. This incident caused many losses. In this regard, a study was conducted to observe the reflectivity products to identifiy the hook echo or bow echo patterns, and the velocity products for mesocyclone patterns as the characteristic of the Puting Beliung used radar product. The study required the Cengkareng C-Band raw data radar that was processed to produce CMAX, VCUT, and CAPPI (V) at 0.5 km, 1.0 km, and 1.5 km elevations overlay by HWIND. The CMAX and VCUT radar products are used to identify the cloud structure that caused Puting Beliung, by observed the highest reflectivity of the Puting Beliung-producing clouds. Then the CAPPI product overlay by HWIND is used to identify the movement of the wind which is suspected to be the beginning of the formation of a Puting Beliung at that location which is characterized by the presence of a mesocyclone pattern in the form of wind components and radial velocity. It was suspected that there was a wind rotating in the Central Jakarta area which indicated a Puting Beliung in the area. The analysis of this radar interpretation was then validated using satellite imagery to detect the cumulonimbus clouds forming the Puting Beliung. From this research, it is known that the Puting Beliung occurred around 08.12 UTC. The growth of cyclone-producing clouds occurred rapidly with a reflectivity value between 35 - 45 dBZ and wind speed up to 35 knots. Analysis of satellite imagery showed a significant decrease in cloud peak temperature so that the formation of convective clouds in the form of Cumulonimbus clouds indicates the phenomenon of the Puting Beliung. However, in this case study the Puting Beliung phenomenon is indicated as seen from the mesocyclone pattern of the rotating radial velocity component, and not from the hook echo or bow echo pattern.</em>
21
Mahaesa, Rafi, and Syamsul Huda. "POTENSI SEKTOR UNGGULAN KABUPATEN PASURUAN DAN KABUPATEN MOJOKERTO." Jurnal Dinamika Ekonomi Pembangunan 5, no. 1 (January 28, 2022): 553–62. http://dx.doi.org/10.33005/jdep.v5i1.314.
Abstract:
The purpose of this study is to examine the key sectors of Pasuruan and Mojokerto districts. Applying the type of quantitative descriptive study. When using the data in this study, it is the Regional Gross Domestic Product, which is categorized based on constant prices based on the business field for the 2016-2020 period. The analytical model used is Location Quotient, Shift Share, Kalssen Typology and Overlay. The results of this assessment show that the leading sector in Pasuruan and Mojokerto is the manufacturing sector. With this research, the government can optimize its economic sector so as to create economic equality from the regional to the national level. national development is based on planning and development of various regions to be improved. The increase in the creativity of economic work can be one of the parameters for the success of the development of a region.
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Popadić, Daliborka, Nemanja Gavrilov, Ljubiša Ignjatović, Danina Krajišnik, Slavko Mentus, Maja Milojević-Rakić, and Danica Bajuk-Bogdanović. "How to Obtain Maximum Environmental Applicability from Natural Silicates." Catalysts 12, no. 5 (May 5, 2022): 519. http://dx.doi.org/10.3390/catal12050519.
Abstract:
Unmodified natural silicates (bentonite, kaolin, clinoptilolite and diatomites) were tested as adsorbents for the organic pollutants in water tables using Methylene Blue (MB) as the model adsorbate. Among the selected materials, bentonite adsorbed as much as 237 mg/g, confirming its excellent suitability for pollutant removal. Spectral evidence confirmed successful MB immobilization at the bentonite surface. Furthermore, the thermal treatment of MB-saturated adsorbent in an inert atmosphere at 700 °C produced a carbon/silicate composite. EDX confirmed the formation of the nitrogen-doped carbon overlay on the silica scaffold and the obtained composite material was probed as an electrode material for oxygen reduction in an alkaline solution. Reduction proceeded via a two-electron mechanism with the main product being HO2−, a known nucleophile, which was subsequently used to degrade/demethylate MB. The composite showed a considerable 70% MB removal rate after an hour of electrochemical treatment. The synergy between the processes of adsorption of MB and the surface-generated HO2− dictates the efficiency of the method and points to a possible route for spent adsorbent reuse in the form of a durable product for environmental protection.
23
Wirawan, Dandy Ananda Patria. "Analysis Of The Leading Sector Of Ambon City During The Covid-19 Pandemic." Jurnal Pajak dan Keuangan Negara (PKN) 5, no. 1 (August 23, 2023): 46–54. http://dx.doi.org/10.31092/jpkn.v5i1.2248.
Abstract:
Gross Regional Domestic Product (GDP) is a major factor in viewing economic growth in a region. High production will contribute to Regional Original Income (PAD), which can later be used by regions to build infrastructure and other regional needs. However, the COVID-19 pandemic that has hit Indonesia has hampered the economy. This condition also hit Ambon City which is the capital of Maluku Province. The COVID-19 pandemic has had a different impact on every business sector in Ambon City. Through analysis of Location Quotient (LQ), Dynamic Location Quotient (DLQ), and Shift-share, also supported by using overlay identification analysis, conclusions were drawn when entering the COVID-19 pandemic, the period 2016 to 2020, the leading sector in Ambon City was the Financial Services and Insurance as well as Government Administration, Defense, and Compulsory Social Security sectors.
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LEINWEBER, Barbara D., Paul C. LEAVIS, Zenon GRABAREK, C. L. Albert WANG, and Kathleen G. MORGAN. "Extracellular regulated kinase (ERK) interaction with actin and the calponin homology (CH) domain of actin-binding proteins." Biochemical Journal 344, no. 1 (November 8, 1999): 117–23. http://dx.doi.org/10.1042/bj3440117.
Abstract:
An interaction between extracellular regulated kinase 1 (ERK1) and calponin has previously been reported (Menice, Hulvershorn, Adam, Wang and Morgan (1997) J. Biol. Chem.272(40), 25157-25161) and has been suggested to reflect a function of calponin as a signalling molecule. We report in this study that calponin binds to both ERK1 and ERK2 under native conditions as well as in an overlay assay. Using chymotryptic fragments of calponin, the binding site of ERK on calponin was identified as the calponin homology (CH) domain, an N-terminal region of calponin found in other actin-binding proteins. ERK also bound, in a gel overlay assay, α-actinin, a protein with two tandem CH domains, as well as a 27 kDa thermolysin product of α-actinin containing the CH domains of α-actinin. The CH domain of calponin could compete with intact calponin or α-actinin for ERK binding. Titration of acrylodan-labelled calponin with ERK gave a Ka of 6×106 M-1 and titration of acrylodan-labelled calponin with a peptide from the αL16 helix of ERK gave a Ka of 1×106 M-1. Recombinant ERK was found to co-sediment with purified actin and induced a fluorescence change in pyrene-labelled F-actin (Ka = 5×106 M-1). The interaction of ERK with CH domains points to a new potential function for CH domains. The interaction of ERK with actin raises the possibility that actin may provide a scaffold for ERK signalling complexes in both muscle and non-muscle cells.
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Ganzha, Anhelina. "Polyphonizm of narrative in documentary film (On the case of films about P. Tychyna, M. Rylskyi, V. Sosiura)." Culture of the Word, no. 90 (2019): 150–64. http://dx.doi.org/10.37919/0201-419x-2019.90.13.
Abstract:
Narratives in cinema text are seen as narratives of interrelated events occurring within specific space-time frames involving the author, narrator and characters. The intermedical nature of documentary filmmaking complicates its analysis in the coordinates of any research paradigm. However, among the universal categories of reception of film narratives, polyphonicism should be singled out as a means of creating a holistic view of a cultural product. The article offers the authorʼs vision of realization of the polyphonism of the film narrative in the documentaries “I Call You” (2006), “Poeta Maximus” (2008), “So No One Loved” (2008) from the series “Game of Fate”. It is concluded that there is a certain plot-compositional scheme of organization of audiovisual polyphonic narrative in the series. Among the specific figures of the screen narration in the analyzed documentary tapes we see transposition (eg, transition from the direct speech of the presenter to a voice-over commentary on a movie quote), overlay (simultaneous use of the “chronicle of the epoch” with the off-screen reading of an excerpt from an artistic text), photos and video snippets).
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Strand, D., R. Jakobs, G. Merdes, B. Neumann, A. Kalmes, H. W. Heid, I. Husmann, and B. M. Mechler. "The Drosophila lethal(2)giant larvae tumor suppressor protein forms homo-oligomers and is associated with nonmuscle myosin II heavy chain." Journal of Cell Biology 127, no. 5 (December 1, 1994): 1361–73. http://dx.doi.org/10.1083/jcb.127.5.1361.
Abstract:
Inactivation of the Drosophila lethal(2)giant larvae (l(2)gl) gene causes malignant tumors in the brain and the imaginal discs and produces developmental abnormalities in other tissues, including the germline, the ring gland and the salivary glands. Our investigations into the l(2)gl function have revealed that the gene product, or p127 protein, acts as a cytoskeletal protein distributed in both the cytoplasm and on the inner face of lateral cell membranes in a number of tissues throughout development. To determine whether p127 can form oligomers or can stably interact with other proteins we have analyzed the structure of the cytosolic form of p127. Using gel filtration and immunoaffinity chromatography we found that p127 is consistently recovered as high molecular weight complexes that contain predominantly p127 and at least ten additional proteins. Blot overlay assays indicated that p127 can form homo-oligomers and the use of a series of chimaeric proteins made of segments of p127 fused to protein A, which alone behaves as a monomer, showed that p127 contains at least three distinct domains contributing to its homo-oligomerization. Among the proteins separated from the immuno-purified p127 complexes or isolated by virtue of their affinity to p127, we identified one of the proteins by microsequencing as nonmuscle myosin II heavy chain. Further blot overlay assay showed that p127 can directly interact with nonmuscle myosin II. These findings confirm that p127 is a component of a cytoskeletal network including myosin and suggest that the neoplastic transformation resulting from l(2)gl gene inactivation may be caused by the partial disruption of this network.
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Laisa, Muhammad Ikbal, Sulistijono Sulistijono, and Jatmoko Awali. "Effect of Heat Input with Current Variation on Weld Overlay GTAW Method with ERNi-CI and ERNiFe-CI Fillers on Mechanical Properties and Micro Structure of Main Cap Product." IPTEK Journal of Proceedings Series, no. 4 (July 30, 2018): 33. http://dx.doi.org/10.12962/j23546026.y2018i4.3842.
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Saunders, Ginny C., Juliet Dukes, Helen C. Parkes, and Johanne H. Cornett. "Interlaboratory Study on Thermal Cycler Performance in Controlled PCR and Random Amplified Polymorphic DNA Analyses." Clinical Chemistry 47, no. 1 (January 1, 2001): 47–55. http://dx.doi.org/10.1093/clinchem/47.1.47.
Abstract:
Abstract Background: Intercomparisons of PCR-based data between laboratories require an assurance of assay reproducibility. We performed an interlaboratory study to investigate the contribution made by a variety of thermal cyclers to PCR performance as measured by interblock reproducibility and intrablock repeatability. Methods: Two standardized assays designed to minimize the introduction of non-thermal-cycler-dependent variations were evaluated by 18 laboratories in the United Kingdom, using 33 thermal cyclers of various makes and models. We used a single-product (590 bp) PCR, established in our laboratory as a robust and specific reaction. The second reaction, a multiproduct random amplified polymorphic DNA (RAPD) PCR, was known to be more susceptible to small changes in block temperature and was therefore considered a way of assessing block uniformity with respect to temperature. Assay repeatability data were analyzed with respect to temperature calibration status, the type of temperature control mechanism, thermal cycler age, and the presence of oil overlay or heated lid systems. Results: All (100%) of the laboratories produced the correct target for the single-product PCR assay, although substantial variation in yield in replicate reactions was observed in 9.4% of these. The RAPD reaction generated results that varied extensively both within the same block and between different thermal cyclers. For eight replicates of a positive sample, 88% intrablock repeatability was demonstrated in calibrated thermal cyclers, which decreased to 63% in noncalibrated instruments. Conclusions: Irrespective of the make and model of thermal cycler, temperature-calibrated instruments consistently generated more repeatable RAPD data than noncalibrated instruments. Guidelines are offered on optimizing and monitoring thermal cycler performance.
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Li, Mei, Luming Zhou, Robert A. Palais, and Carl T. Wittwer. "Genotyping Accuracy of High-Resolution DNA Melting Instruments." Clinical Chemistry 60, no. 6 (June 1, 2014): 864–72. http://dx.doi.org/10.1373/clinchem.2013.220160.
Abstract:
Abstract BACKGROUND High-resolution DNA melting is a closed-tube method for genotyping and variant scanning that depends on the thermal stability of PCR-generated products. Instruments vary in thermal precision, sample format, melting rates, acquisition, and software. Instrument genotyping accuracy has not been assessed. METHODS Each genotype of the single nucleotide variant (SNV) (c.3405–29A>T) of CPS1 (carbamoyl-phosphate synthase 1, mitochondrial) was amplified by PCR in the presence of LCGreen Plus with 4 PCR product lengths. After blinding and genotype randomization, samples were melted in 10 instrument configurations under conditions recommended by the manufacturer. For each configuration and PCR product length, we analyzed 32–96 samples (depending on batch size) with both commercial and custom software. We assessed the accuracy of heterozygote detection and homozygote differentiation of a difficult, nearest-neighbor symmetric, class 4 variant with predicted ΔTm of 0.00 °C. RESULTS Overall, the heterozygote accuracy was 99.7% (n = 2141), whereas homozygote accuracy was 70.3% (n = 4441). Instruments with single sample detection as opposed to full-plate imaging better distinguished homozygotes (78.1% and 61.8%, respectively, χ2P < 0.0005). Custom software improved accuracy over commercial software (P < 0.002), although melting protocols recommended by manufacturers were better than a constant ramp rate of 0.1 °C with an oil overlay. PCR products of 51, 100, 272, and 547 bp had accuracies of 72.3%, 83.1%, 59.8%, and 65.9%, respectively (P < 0.0005). CONCLUSIONS High-resolution melting detects heterozygotes with excellent accuracy, but homozygote accuracy is dependent on detection mode, analysis software, and PCR product size, as well as melting temperature differences between, and variation within, homozygotes.
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Said, Muh, Feri Padli, Muhammad Zulfadli, and Syarifah Balqis. "Mapping the Poverty Rate of The South Sulawesi Region." SHS Web of Conferences 149 (2022): 01029. http://dx.doi.org/10.1051/shsconf/202214901029.
Abstract:
This research purpose to presenting information on a smaller regional scale and comparing the conditions of each region. Researchers conducted a poverty mapping technique based on geospatial information. Utilizing the Geographic Information System (GIS) application, namely ArcMap with conversion tools techniques. Data collection techniques with literature study. The poverty level data is processed into tabulation form in the excel application. Meanwhile, the regional base map is first input into the ArcMap application to overlay all regions in one province. The product is a map of the poverty level of the district/city community in the administrative area of South Sulawesi Province. The map will show an image of the area by color category. The dark color gradation means the area with the highest poverty rate and the lightest color means the area with the lowest poverty rate. The results obtained indicate that the districts with the highest poverty rates are Makassar City and Bone District. Meanwhile, the areas with the lowest poverty rates are Barru Regency, Sidenreng Rappang Regency, Pare-Pare City and Palopo City.
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Meine, Timo C., Cornelia L. A. Dewald, L. S. Becker, Aline Mähringer-Kunz, Benjamin Massoumy, Sabine K. Maschke, Martha M. Kirstein, et al. "Transjugular intrahepatic portosystemic shunt placement: portal vein puncture guided by 3D/2D image registration of contrast-enhanced multi-detector computed tomography and fluoroscopy." Abdominal Radiology 45, no. 11 (May 25, 2020): 3934–43. http://dx.doi.org/10.1007/s00261-020-02589-1.
Abstract:
Abstract Background To assess the technical feasibility, success rate, puncture complications and procedural characteristics of transjugular intrahepatic portosystemic shunt (TIPS) placement using a three-dimensional vascular map (3D-VM) overlay based on image registration of pre-procedural contrast-enhanced (CE) multi-detector computed tomography (MDCT) for portal vein puncture guidance. Materials and methods Overall, 27 consecutive patients (59 ± 9 years, 18male) with portal hypertension undergoing elective TIPS procedure were included. TIPS was guided by CE-MDCT overlay after image registration based on fluoroscopic images. A 3D-VM of the hepatic veins and the portal vein was created based on the pre-procedural CE-MDCT and superimposed on fluoroscopy in real-time. Procedural characteristics as well as hepatic vein catheterization time (HVCT), puncture time (PT), overall procedural time (OPT), fluoroscopy time (FT) and the dose area product (DAP) were evaluated. Thereafter, HVCT, PT, OPT and FT using 3D-VM (61 ± 9 years, 14male) were compared to a previous using classical fluoroscopic guidance (53 ± 9 years, 21male) for two interventional radiologist with less than 3 years of experience in TIPS placement. Results All TIPS procedure using of 3D/2D image registered 3D-VM were successful with a significant reduction of the PSG (p < 0.0001). No clinical significant complication occurred. HVCT was 14 ± 11 min, PT was 14 ± 6 min, OPT was 64 ± 29 min, FT was 21 ± 12 min and DAP was 107.48 ± 93.84 Gy cm2. HVCT, OPT and FT of the interventionalist with less TIPS experience using 3D/2D image registered 3D-VM were statistically different to an interventionalist with similar experience using fluoroscopic guidance (pHVCT = 0.0022; pOPT = 0.0097; pFT = 0.0009). PT between these interventionalists was not significantly different (pPT = 0.2905). Conclusion TIPS placement applying registration-based CE-MDCT vessel information for puncture guidance is feasible and safe. It has the potential to improve hepatic vein catherization, portal vein puncture and radiation exposure.
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Cleveland, Gregory S., Robert L. Lytton, and Joe W. Button. "Using Pseudostrain Damage Theory to Characterize Reinforcing Benefits of Geosynthetic Materials in Asphalt Concrete Overlays." Transportation Research Record: Journal of the Transportation Research Board 1849, no. 1 (January 2003): 202–11. http://dx.doi.org/10.3141/1849-22.
Abstract:
Reflective cracking is one of the more serious distresses associated with existing hot-mix asphalt (HMA) or portland concrete cement pavements overlaid with a thin bituminous layer. Preventive maintenance techniques have included incorporating geosynthetic materials (defined here as grids, fabrics, or composites) into the pavement structure. These materials have exhibited varying degrees of success, and their use within a particular agency has been based primarily on local experience or a willingness to try a product that appears to have merit. A methodology is described that was used to compare the relative effectiveness of six commercially available geosynthetic materials in reducing the severity or delaying the appearance of reflective cracking in HMA overlay. Each geosynthetic material was incorporated into compacted HMA specimens and tested to failure. Engineering fracture mechanics and pseudostrain energy concepts based on the elastic-viscoelastic correspondence principle were used and demonstrated to be appropriate and efficient in characterizing the fatigue damage process. By considering the effects of the geosynthetic products on the loading and unloading paths of the HMA specimens, a new concept was developed and termed the reinforcing factor, R. The use of this value allows the industry to characterize the relative reinforcing benefits of geosynthetic materials in reducing reflective cracking in HMA overlays. A crack speed index was then derived to summarize the complex interactions of the material properties. In general, grids and composites performed better than fabrics, which in turn performed better than a thin tacked surface as compared with unreinforced specimens. Design equations were developed between the fracture properties of the geosyntheticmixture system and the relaxation modulus properties of the HMA, which can be used in forward-calculating design methods to predict the rate of crack growth and support the design of an HMA overlay to resist reflective cracking. To calibrate the design equations, comparative field test pavements were constructed in three regions of Texas (Amarillo, Waco, and McAllen) using each geosynthetic material. These pavements will be monitored over the next 4 years.
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Yilmaz, Murat, and Seda Erkan Buğday. "Planning of forest recreation services at provincial scale with a multi-criteria approach." Šumarski list 148, no. 1-2 (February 12, 2024): 29–38. http://dx.doi.org/10.31298/sl.148.1-2.3.
Abstract:
The planning of forest services is becoming more crucial day by day, depending on the people’s tendency to the services provided by forests. For this reason, this study focused on planning of recreation service, which is one of the non-wood forest products and services offered in forests in Türkiye. The distribution of national parks, nature parks, and A-, B-, C-, and D-type recreational areas, which are all types of recreational areas in forests, were evaluated by weighted overlay analysis at the provincial level in Türkiye. The criteria that can express the distribution of people in the country and the forest assets and existing recreational areas (Gross Domestic Product (GDP) per capita, number of people per km2, population growth rate, ratio of forest area to the overall area, and total forest recreation areas) were used. The criteria data of the provinces were rasterized and a reclassify analysis was performed with the obtained raster, dividing data into five categories. Weighted overlay analysis was carried out using the reclass maps. As a result of the analysis, in terms of planning recreational areas, the provinces were divided into three priority categories. The provinces, included in the first priority province category in the study, are those located in the south, east and southeast of Türkiye (where asylum seekers and irregular migrants enter Türkiye), those located along the line extending from the northwest to the interior provinces (important centers of both internal immigration and industrialization) and those located in the middle of Türkiye ( the ones that are poor in terms of forest assets). In this study, it was emphasized that the recreational areas of the provinces are planned to depend on the changing provincial populations with both internal and external migrations and economy. In addition, a different approach is presented to planners to manage of utilization of forest recreation services according to different needs, by evaluating forests and the changing characteristics of society structure altogether.
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Ushakov, I. A., R. I. Dementiev, and D. Y. Derzhko. "Secure data transmission in geographically distributed information systems in ophthalmology based on domestic equipment." Fyodorov journal of ophthalmic surgery, no. 1S (February 17, 2023): 108–14. http://dx.doi.org/10.25276/0235-4160-2022-4s-108-114.
Abstract:
Relevance. Currently, to ensure secure data transmission in geographically distributed information systems, including in ophthalmology, in particular secure data transmission of telemedicine consultations, when exchanging data between various healthcare institutions, when transmitting data during multicenter clinical trials, scientific developments, Multipoint Private Network (DMVPN) technology is widely used. DMVPN allows you to significantly reduce the load on equipment when organizing the work of remote offices. This «overlay» VPN reduces the participation of the provider in organizing a connection with a large number of users compared to analogues of the «peer-to-peer» type. Purpose. To evaluate the features of the transition to Eltex equipment when building a DMVPN in geographically distributed information systems in ophthalmology. Material and methods. Eltex ESR-200 routers were used as a laboratory stand. To measure the throughput of routers, the Iperf3 software product was used – a cross-platform console client-server program. Results. This article provides an assessment of the throughput of Eltex equipment when building secure DMVPN tunnels. Conclusion. Eltex equipment is productive and effective for solving the problems of building secure DMVPN tunnels to ensure secure data transmission in geographically distributed information systems in ophthalmology. Keywords: information security, performance, fault tolerance, DMVPN, IPsec, NHRP, routing, GRE tunnels
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Ahmad Rizani. "ANALYSIS OF ECONOMIC PERFORMANCE AND ECONOMIC POTENTIAL OF EAST JAVA PROVINCE." East Java Economic Journal 1, no. 1 (September 30, 2017): 76–95. http://dx.doi.org/10.53572/ejavec.v1i1.3.
Abstract:
This study aimed to investigate economic growth, regional economic pattern and structure of East Java Province. Other than that, this study also identified anddetermined superior sectors in East Java Province to give an illustration on which superior economic activities to be developed to improve the economic potential in East Java Province. Data employed in this study was secondary data in six years’ time series form 2010 until 2015 about GDP (Gross Domestic Product) for Indonesia, RGDP (Regional Gross Domestic Product) for East Java Province, total population in Indonesia, total population in East Java Province, the number of people living in poverty in Indonesia, and the number of people living in poverty in East Java Province. Data was obtained from Central Statistics Institution Indonesia, National Planning and Development Institution, Central Statistics Institution of East Java Province, and Regional Planning and Development Institution of East Java Province. Analysis tools used in this study included economic performance analysis, ShiftShare, Location Quotient (LQ), Growth Ratio Model (MRP) and Overlay analysis. The results of the study showed that: (1) economic performance index of East Java Province was quite good because during 2011-2015 the province got average economic performance index 0.847; (2) shift-share analysis showed that East Java Province economic showed an improvement during 2010-2015 by 340.769,50 billion rupiahs. Those economic performance improvements in East Java Province could be seen from the positive value of 16 (sixteen) economic activity sectors; (3) according to Location Quotient (LQ) analysis, there were five superior sectors in East Java Province, they were processing industry sector, water procurement sector, waste and recycle management sector, wholesale and retail, auto car and motorcycle reparation sector, accommodation and foods providing sector, and information and communication sector; (4) Growth Ratio Model analysis showed that sectors which had dominants growth and big contribution were construction sector, wholesale and retail, auto car and motorcycle reparation sector, transportation and warehousing sector, accommodation and foods providing sector, information and communication sector financial and insurance service sector, real estate sector, education service sector, health service and social activity sector; (5) Overlay analysis showed that potential economic sector in East Java Province included wholesale and retail, auto car andmotorcycle reparation sector, accommodation and foods providing sector, and information and communication sector; (6) weighing result according to Shift-Share Location Quotient (LQ), and Growth Ratio Model analysis were five sectors based on the highest rank of the most potential weighing result, they were accommodation and foods providing sector, processing industry sector, wholesale and retail, auto car and motorcycle reparation sector, information and communication sector, and construction sector.
JEL Classification : P47, O47, C02, C02, C02, C02
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Hartati, Indah, and Vita Paramita. "Apocarotenoids: Sources, Classification and Their Potential Application as Food Additives." Research in Chemical Engineering (RiCE) 2, no. 2 (November 22, 2023): 44–50. http://dx.doi.org/10.30595/rice.v2i2.112.
Abstract:
Apocarotenoids are the degradation product of the enzymatic and or non enzymatic cleavage of carotenoids. Apocarotenoids are present in plants, fungi, bacteria and a certain animal species. There have been large numbers of apocaretonoids identified as the consequence of the great variety of naturally occurring carotenoids. Apocarotenoids can be found as volatile, semi-volatile or non-volatile compounds based on their chemical structures, while based on the number of the carbon atoms contained in their structure, apocarotenoids is classify into triporoids, cyclofarnesoids and methylhexanoids. Bibliometric analysis performed on publication having “apocarotenoids” keywords informs that crocin, pirocrocin, saffron and crocus sativus nodules appear in the overlay visualization. The appearance is attributed to the great potential application and commercialization of crocin which is originated from saffron. The bibliometric analysis also shows that there is food additive nodule appear which imply the strong correlation and potential application of apocarotenoids as food additive. The potential utilization and the commercial production of apocarotenoids are challenged by the the genetic diversity as well as the high cost, time consuming and seasonal production of natural apocarotenoids isolation process. Chemical synthesis, engineering biosynthesis and bio-manufacturing using microbes provide a promising and economical alternative.
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Izgec, B., and C. S. S. Kabir. "Identification and Characterization of High-Conductive Layers in Waterfloods." SPE Reservoir Evaluation & Engineering 14, no. 01 (December 20, 2010): 113–19. http://dx.doi.org/10.2118/123930-pa.
Abstract:
Summary This study expands upon the use of modified-Hall analysis (MHA) to discern the characteristics of a high-permeability channel. Briefly, the modified-Hall plot uses three curves involving improved Hall-integral (H-I) and the two derivatives, analytic and numeric. Ordinarily, the derivative curves overlay on the integral curve during matrix injection, but separate lower when fracturing occurs. This work presents a method to identify and characterize high-conductive layers or channels between injector and producer pairs with the MHA. The distance separating the integral and derivative curves provides the required information to quantify channel properties. A simple analytical solution is presented for transforming the separation distance into channel permeabilitythickness product. The analytic derivative is based on the radial-flow-pattern assumption and the numeric derivative is correlated to the pressure response. Therefore, a comparison of these two curves reveals clues about the maturity of a waterflood at a given time. Several simulated examples verified the channel-property-estimation algorithm and identified the distinctive derivative signatures for channeling and fracturing situations. This method is also useful for identification of wormhole propagation during sand production in unconsolidated formations.
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Masdupi, Erni, Tri Kurniawati, Halkadri Fitra, and Dini Faisal. "Desain Motif sebagai Brand Strategy Pengembangan Galeri Sulam Pinjaik Patah Kabupaten Agam Sumatra Barat." ANDHARUPA: Jurnal Desain Komunikasi Visual & Multimedia 8, no. 02 (November 3, 2022): 246–56. http://dx.doi.org/10.33633/andharupa.v8i02.5443.
Abstract:
Abstrak Pinjaik patah atau jarum jahit yang dipatahkan merupakan brand yang cukup dikenal untuk persoalan produk sulaman terawang di Sumatra Barat, khususnya di kabupaten Agam, Nagari Panampuang. Sayangnya, pengembangan motif yang dilakukan masih minim sehingga diversifikasi produk, pembeda produk hasil sulaman pinjaik patah dan hasil produk kompetitor tidak dapat dibedakan. Perlu dirancang sebuah desain motif baru yang berangkat dari picture mark logo galeri sulam pinjaik patah dengan tujuan untuk menciptakan diversifikasi produk dan brand awareness sulaman pinjaik patah. Metode yang digunakan adalah research and development dengan tahapan 1) Potensi dan Masalah; 2) Pengumpulan informasi; 3) Pengembangan model; 4) Validasi model; 5) Uji coba model. Hasil yang didapatkan yaitu perajin sulaman dapat mengaplikasikan desain motif dalam jenis sulaman terawang dan sulaman menggunakan bordir, hanya saja masih diperlukan revisi dan latihan dari perajin sulaman agar dapat menghasilkan motif yang harmonis. Pengembangan desain dan produk sebaiknya difokuskan pada sulaman terawang yang menjadi unggulan sulam pinjaik patah. Kata kunci: brand awareness, desain motif, pinjaik patah, sulaman AbstractPinjaik patah or a broken sewing needle is a well-known brand for embroidery products in West Sumatra, especially in Agam district, Nagari Panampuang. Unfortunately, the development of the motifs is still minimal so that product diversification, the difference between the product of pinjaik patah embroidery and the product of competitors cannot be distinguished. It is necessary to design a new motif design that departs from the picture mark of the Pinjaik Patah embroidery gallery logo with the aim of creating product diversification and brand awareness of Pinjaik Patah embroidery. The method used is research and development which includes five steps like 1) potentials and problems; 2) gathering information; 3) designing; 4) validation and; 5) design testing. The results obtained are that the embroiderer can apply the motif design in the type of overlay embroidery and embroidery using embroidery, it's just that revision and practice from the embroiderer is still needed in order to produce a harmonious motif. Design and product development should be focused on terawang embroidery which is the flagship of pinjaik patah embroidery. Keywords: brand awareness, embroidery, motif design, pinjaik patah
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Lawag, Ivan Lozada, Tomislav Sostaric, Lee Yong Lim, Katherine Hammer, and Cornelia Locher. "The Development and Application of a HPTLC-Derived Database for the Identification of Phenolics in Honey." Molecules 27, no. 19 (October 6, 2022): 6651. http://dx.doi.org/10.3390/molecules27196651.
Abstract:
This study reports on the development and validation of a HPTLC-derived database to identify phenolic compounds in honey. Two database sets are developed to contain the profiles of 107 standard compounds. Rich data in the form of Rf values, colour hues (H°) at 254 nm and 366 nm, at 366 nm after derivatising with natural product PEG reagent, and at 366 nm and white light after derivatising with vanillin–sulfuric acid reagent, λ max and λ min values in their fluorescence and λ max values in their UV-Vis spectra as well as λ max values in their fluorescence and UV-Vis spectra after derivatisation are used as filtering parameters to identify potential matches in a honey sample. A spectral overlay system is also developed to confirm these matches. The adopted filtering approach is used to validate the database application using positive and negative controls and also by comparing matches with those identified via HPLC-DAD. Manuka honey is used as the test honey and leptosperine, mandelic acid, kojic acid, lepteridine, gallic acid, epigallocatechin gallate, 2,3,4-trihydroxybenzoic acid, o-anisic acid and methyl syringate are identified in the honey using the HPTLC-derived database.
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Nazareth, Tiago de Melo, Jorge Calpe, Carlos Luz, Jordi Mañes, and Giuseppe Meca. "Manufacture of a Potential Antifungal Ingredient Using Lactic Acid Bacteria from Dry-Cured Sausages." Foods 12, no. 7 (March 27, 2023): 1427. http://dx.doi.org/10.3390/foods12071427.
Abstract:
The growing interest in functional foods has fueled the hunt for novel lactic acid bacteria (LAB) found in natural sources such as fermented foods. Thus, the aims of this study were to isolate, identify, characterize, and quantify LAB’s antifungal activity and formulate an ingredient for meat product applications. The overlay method performed a logical initial screening by assessing isolated bacteria’s antifungal activity in vitro. Next, the antifungal activity of the fermented bacteria-free supernatants (BFS) was evaluated by agar diffusion assay against six toxigenic fungi. Subsequently, the antifungal activity of the most antifungal BFS was quantified using the microdilution method in 96-well microplates. The meat broth that showed higher antifungal activity was selected to elaborate on an ingredient to be applied to meat products. Finally, antifungal compounds such as organic acids, phenolic acids, and volatile organic compounds were identified in the chosen-fermented meat broth. The most promising biological candidates belonged to the Lactiplantibacillus plantarum and Pediococcus pentosaceus. P. pentosaceus C15 distinguished from other bacteria by the production of antifungal compounds such as nonanoic acid and phenyl ethyl alcohol, as well as the higher production of lactic and acetic acid.
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Kirby, James, Minobu Nishimoto, Ruthie W. N. Chow, Venkata N. Pasumarthi, Rossana Chan, Leanne Jade G. Chan, Christopher J. Petzold, and Jay D. Keasling. "Use of Nonionic Surfactants for Improvement of Terpene Production in Saccharomyces cerevisiae." Applied and Environmental Microbiology 80, no. 21 (August 22, 2014): 6685–93. http://dx.doi.org/10.1128/aem.02155-14.
Abstract:
ABSTRACTTo facilitate enzyme and pathway engineering, a selection was developed for improved sesquiterpene titers inSaccharomyces cerevisiae. α-Bisabolene, a candidate advanced biofuel, was found to protect yeast against the disruptive action of nonionic surfactants such as Tween 20 (T20). An experiment employing competition between two strains of yeast, one of which makes twice as much bisabolene as the other, demonstrated that growth in the presence of T20 provided sufficient selective pressure to enrich the high-titer strain to form 97% of the population. Following this, various methods were used to mutagenize the bisabolene synthase (BIS) coding sequence, coupled with selection by subculturing in the presence of T20. Mutagenesis targeting the BIS active site did not yield an improvement in bisabolene titers, although mutants were found which made a mixture of α-bisabolene and β-farnesene, another candidate biofuel. Based on evidence that the 3′ end of the BIS mRNA may be unstable in yeast, we randomly recoded the last 20 amino acids of the enzyme and, following selection in T20, found a variant which increased specific production of bisabolene by more than 30%. Since T20 could enrich a mixed population, efficiently removing strains that produced little or no bisabolene, we investigated whether it could also be applied to sustain high product titers in a monoculture for an extended period. Cultures grown in the presence of T20 for 14 days produced bisabolene at titers up to 4-fold higher than cultures grown with an overlay of dodecane, used to sequester the terpene product, and 20-fold higher than cultures grown without dodecane.
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Reed, Gudrun H., and Carl T. Wittwer. "Sensitivity and Specificity of Single-Nucleotide Polymorphism Scanning by High-Resolution Melting Analysis." Clinical Chemistry 50, no. 10 (October 1, 2004): 1748–54. http://dx.doi.org/10.1373/clinchem.2003.029751.
Abstract:
Abstract Background: Screening for heterozygous sequence changes in PCR products, also known as “mutation scanning”, is an important tool for genetic research and clinical applications. Conventional methods require a separation step. Methods: We evaluated the sensitivity and specificity of homogeneous scanning, using a saturating DNA dye and high-resolution melting. Heterozygous single-nucleotide polymorphism (SNP) detection was studied in three different sequence backgrounds of 40%, 50%, and 60% GC content. PCR products of 50–1000 bp were generated in the presence of LCGreen™ I. After fluorescence normalization and temperature overlay, melting curve shape was used to judge the presence or absence of heterozygotes among 1632 cases. Results: For PCR products of 300 bp or less, all 280 heterozygous and 296 wild-type cases were correctly called without error. In 672 cases between 400 and 1000 bp with the mutation centered, the sensitivity and specificity were 96.1% and 99.4%, respectively. When the sequence background and product size with the greatest error rate were used, the sensitivity of off-center SNPs (384 cases) was 95.6% with a specificity of 99.4%. Most false negatives occurred with SNPs that were compared with an A or T wild type sequence. Conclusions: High-resolution melting analysis with the dye LCGreen I identifies heterozygous single-base changes in PCR products with a sensitivity and specificity comparable or superior to nonhomogeneous techniques. The error rate of scanning depends on the PCR product size and the type of base change, but not on the position of the SNP. The technique requires only PCR reagents, the dye LCGreen I, and 1–2 min of closed-tube, post-PCR analysis.
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Wei, Zengqi. "The Impact of Co-branding on Brand Marketing: A Case Study of Holiland." Advances in Economics, Management and Political Sciences 38, no. 1 (November 10, 2023): 79–83. http://dx.doi.org/10.54254/2754-1169/38/20231890.
Abstract:
Co-branding is one of the most popular marketing models used by most well-known brands in recent years to attract the attention of a large number of consumers and to stimulate their desire to buy. The essence of co-branding is to create new products through collaboration, often with the characteristics and labels of both parties. Through a partnership model where both parties cooperate with each other, it is easier to break the stereotype about the brand image and expand the consumer market, thus increasing the commercial value of the brand and product. In recent years, Holiland has conducted co-branded marketing with different brands and celebrities, which has achieved a complementary overlay of consumer groups and inspired customer resonance through the integration of resources. In this paper, the author explores the strategy of Holiland's co-branding marketing and analyses the positive and negative impacts of co-branding on Holiland's brand marketing by means of a questionnaire survey. The study finds that the transfer of emotional value generated by co-branding promotes the effective complementarity of both consumer groups, but too frequent brand crossover may bring some negative effects, therefore, Holiland can be more flexible in future co-branding marketing by using a variety of marketing models, choosing suitable co-branding partners, and giving advance publicity. In addition, Holiland can pay further attention to the value of co-branded products and consider the introduction of localized marketing.
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Kuruvachalil, Lujain, Malindu Sandanayake, Ramya Kumanayake, and Radhakrishna. "Carbon Emission and Cost Analysis of Using Hybrid Fibre White Topping Overlays—A Road Rehabilitation Feasibility Study." Future Transportation 2, no. 1 (March 3, 2022): 263–80. http://dx.doi.org/10.3390/futuretransp2010014.
Abstract:
White topping is a popular road rehabilitation technique that uses Portland cement concrete overlay on top of any existing bituminous pavement. However, this often results in additional cost and carbon emission escalations which complicates market useability of the product. The current study aims at comparing carbon emission and manufacturing cost of concrete topping mixes with three different fibre types. The study optimises the benefits and promotes the use of effective materials in sustainable road rehabilitation. Samples with polyolefin-twisted (F2) fibres indicated least carbon emission escalation while the sample with polypropylene (F3) exhibited least cost escalation with 0.75% and 7.17% from the control sample respectively. A multi-objective genetic optimisation study was conducted to identify the mix designs with least carbon emission and production cost escalations. Sensitivity analysis illustrated that transport distance is a critical contributing factor for production cost while carbon emission is highly sensitive to emission factors for transport and cement production. These results indicate the importance of considering locally available materials and clean energy for production processes. Future research can be focused on exploring the long-term environmental and economic benefits including the durability characteristics to benchmark the sustainable benefits of using waste fibre materials in the mix.
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Farangitakis, G. P., O. G. Brentas, E. Andreadakis, and E. Lekkas. "SEISMIC RISK ASSESSMENT IN THE ATTICA BASIN." Bulletin of the Geological Society of Greece 50, no. 3 (July 27, 2017): 1415. http://dx.doi.org/10.12681/bgsg.11854.
Abstract:
This paper aims to determine the exposure-based earthquake risk posed in the Attica Basin, Greece using a GIS based methodology. The hazard level is based on grouped geological formations according to the New Ground Anti-Earthquake Regulation of Greece and the structural setting of the area. Vulnerability is calculated using two different methodologies. The first one uses a deterministic approach by attributing population values to each building block divided by the of each municipality and the second one uses a probabilistic approach by using centroids based on a building block level and then creating their kernel density. Both of these approaches are combined with land use maps to create the final vulnerability layers. Risk is calculated in two ways, using the product and a weighted overlay of the hazard and vulnerability layers. In the Risk maps, proof of concept comes from overlaying the damages from the earthquakes of 1981 and 1999 that affected Attica Basin. Moreover, both the maps show high Risk probability in the area of the east part of the Attica Basin but without significant damages from past earthquakes. This suggests that the Kifisos Fault Zone might act as a seismic barrier depending of the location of the epicentre.
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Aadi Jindal. "Augmented Reality Applications in Mechanical System Design and Prototyping." Darpan International Research Analysis 12, no. 3 (July 1, 2024): 1–13. http://dx.doi.org/10.36676/dira.v12.i3.51.
Abstract:
With the integration of computer-generated images and data into the real world, augmented reality (AR) is a game-changing technology that improves users' perceptions and interactions with their surroundings. This technology, which can overlay digital data on real-world environments, has great potential for use in several fields, such as mechanical system design and prototyping. The use of AR in this industry is not just a theoretical idea; rather, it is a rapidly developing reality with enormous potential for creativity, effectiveness, and accuracy. Augmented Reality (AR) is a technology that combines the physical and digital worlds to provide a composite vision that improves the user's sense of reality. Augmented Reality (AR) superimposes digital data in real-time over the actual world, in contrast to Virtual Reality (VR), which submerges users in a fully digital environment. Usually, gadgets like tablets, smartphones, AR glasses, and head-mounted displays (HMDs) help with this integration. The term "mechanical system design" describes the entire process of imagining, creating, and perfecting mechanical parts and systems; it includes everything from rough concept drawings to intricate engineering models and simulations. Before moving on with full-scale manufacturing, prototyping entails building early models or samples of a product to test and verify design concepts.
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Assavalapsakul, Wanchai, Duncan R. Smith, and Sakol Panyim. "Identification and Characterization of a Penaeus monodon Lymphoid Cell-Expressed Receptor for the Yellow Head Virus." Journal of Virology 80, no. 1 (January 1, 2006): 262–69. http://dx.doi.org/10.1128/jvi.80.1.262-269.2006.
Abstract:
ABSTRACT The yellow head virus is a positive-sense, single-stranded RNA virus that causes significant mortality in farmed penaeid shrimp. This study sought to isolate and characterize the receptor protein used by the virus to gain entry into Penaeus monodon Oka (lymphoid) organ cells, a primary target of yellow head virus infections. Virus overlay protein binding assay on Oka organ membrane preparations identified a 65-kDa protein, and antibodies raised against this protein inhibited virus entry in primary Oka cell cultures by approximately 80%. N-terminal sequence analysis of the 65-kDa protein generated a 17-amino acid peptide fragment which was used to design degenerate primers that amplified a 1.5-kbp product from Oka organ total RNA, which was cloned and sequenced. Northern analysis and PCR were used to confirm a single RNA transcript that was expressed in most tissues. Subsequently, the mature cDNA was recloned and the expressed protein shown to cross-react with the antibody raised against the original virus binding band. Down regulation of the message through double-stranded RNA-mediated RNA interference silencing resulted in the complete inhibition of virus entry. While the identity of the clone remains unknown, it nevertheless represents the first invertebrate Nidovirus receptor isolated to date.
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Fitriyanti, Sarah Nabila, Purwadi, and Moch Arifin. "Land suitability in sustainable cultivation practices for porang (Amorphophallus oncophyllus L.) in Pasuruan Regency, Indonesia." Jurnal Ilmiah Pertanian 20, no. 2 (July 12, 2023): 163–74. http://dx.doi.org/10.31849/jip.v20i2.13291.
Abstract:
Porang (Amorphophallus oncophyllus L.) stands as a prominent agricultural product in Indonesia. As the demand for porang continues to grow, it becomes crucial to balance it with the expansion of suitable land for cultivation. The selection of appropriate land for crop planting requires a thorough analysis of land feasibility, commonly known as land suitability assessment. This study aims to evaluate land feasibility, identify limiting factors, and explore potential solutions for sustainable cultivation of porang in Sumberejo Village, Pasuruan, East Java. The research was employed by a matching method for land suitability assessment based on climatic, physical, and chemical data. The development of a land suitability map was achieved through the overlay of various stages using land characteristic information. The findings reveal that the residents' lands fall within the actual land classes of S3 (suitable marginal) and N (not suitable), with base saturation (nr3) and slope (eh) identified as the primary limiting factors. To improve the suitability of the selected lands, several recommendations were proposed, including the implementation of cover crops, terracing practices, and the addition of potassium-rich organic matter derived from bamboo waste. These recommendations have the potential to elevate the land class to S2 (suitable) and S3 (suitable marginal), thereby addressing the identified limitations and promoting sustainable porang cultivation.
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Caradonna, Grazia, Antonio Novelli, Eufemia Tarantino, Raffaela Cefalo, and Umberto Fratino. "A Webgis Framework for Disseminating Processed Remotely Sensed on Land Cover Transformations." Reports on Geodesy and Geoinformatics 100, no. 1 (June 1, 2016): 27–38. http://dx.doi.org/10.1515/rgg-2016-0004.
Abstract:
Abstract Mediterranean regions have experienced significant soil degradation over the past decades. In this context, careful land observation using satellite data is crucial for understanding the long-term usage patterns of natural resources and facilitating their sustainable management to monitor and evaluate the potential degradation. Given the environmental and political interest on this problem, there is urgent need for a centralized repository and mechanism to share geospatial data, information and maps of land change. Geospatial data collecting is one of the most important task for many users because there are significant barriers in accessing and using data. This limit could be overcome by implementing a WebGIS through a combination of existing free and open source software for geographic information systems (FOSS4G). In this paper we preliminary discuss methods for collecting raster data in a geodatabase by processing open multi-temporal and multi-scale satellite data aimed at retrieving indicators for land degradation phenomenon (i.e. land cover/land use analysis, vegetation indices, trend analysis, etc.). Then we describe a methodology for designing a WebGIS framework in order to disseminate information through maps for territory monitoring. Basic WebGIS functions were extended with the help of POSTGIS database and OpenLayers libraries. Geoserver was customized to set up and enhance the website functions developing various advanced queries using PostgreSQL and innovative tools to carry out efficiently multi-layer overlay analysis. The end-product is a simple system that provides the opportunity not only to consult interactively but also download processed remote sensing data.
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Triansyah, Fadli Agus, Ashari Gunawan, and Resti Ramadhaniyati. "Factors of Indonesia Economic Growth (2017-2022)." Jurnal Pendidikan Ekonomi Dan Bisnis (JPEB) 11, no. 01 (March 29, 2023): 51–65. http://dx.doi.org/10.21009/jpeb.011.1.5.
Abstract:
Economic growth is measured by changes in a country’s Gross Domestic Product (GDP), which can be unraveled into the population and economic elements. This research is conducted to find trends and identify publications on economic growth in Indonesia in the 2017–2022 period. The data collection techniques by downloading files from the Scopus database to see publication trends with the highest number of documents, ranking classifications of institutions or universities, journals, and documents, and using shared keywords. The method used is bibliometric analysis. A total of 168 documents collected from the Publish or Perish (PoP) application using the Scopus database were combined into one file in RIS format and entered into the VOSviewer application to obtain network visualization and overlay visualization. The study results show that the trend of publications related to economic growth in Indonesia for the last six years has decreased yearly. The highest number of documents is in the “International Journal of Energy Economics and Policy,” with 20 documents, followed by the Haseeb (2019) article, totaling 120 citations. Based on the keywords that have been visualized, several keywords are factors of economic growth in Indonesia from 2017 to 2022, namely Energy Consumption, Investment, CO2 Emissions, Education, GDP, Inflation, FDI, Exchange Rate, Export, Government Expenditure, Income Inequality, Inequality, Human Capital, Human Development Index, and Sustainable Development.