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Journal articles on the topic 'On-Demand release'

Author: Grafiati

Published: 5 October 2024

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1

Field, Rachel D., Margaret A. Jakus, Xiaoyu Chen, Kelia A. Human, Xuanhe Zhao, Parag V. Chitnis, and Samuel K. Sia. "Ultrasound-responsive hydrogel microcapsules for on-demand drug release." Journal of the Acoustical Society of America 154, no. 4_supplement (October 1, 2023): A279. http://dx.doi.org/10.1121/10.0023522.

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Hydrogel-based implantable systems offer viable solutions for localized drug delivery but often lack the ability to easily achieve on-demand actuation or real-time tuning of release kinetics in response to physiological changes. Here, we present a hydrogel microcapsules produced using two-phase microfluidics that can release drugs on demand as triggered by focused ultrasound (FUS). The biphasic microcapsules consist of an outer phase of mixed molecular weight (MW) poly(ethylene glycol) diacrylate that mitigates premature payload release and an inner phase of high MW dextran with payload that breaks down in response to FUS. Compound release from microcapsules could be triggered as desired; 0.4 μg of payload was released across 16 on-demand steps over days. We detected broadband acoustic signals amidst low heating, suggesting inertial cavitation as a key mechanism for payload release. Overall, FUS-responsive microcapsules are a biocompatible and wirelessly triggerable structure for on-demand drug delivery over days to weeks.

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2

Wood, Jonathan. "Coatings release corrosion inhibitors on demand." Materials Today 8, no. 10 (October 2005): 10. http://dx.doi.org/10.1016/s1369-7021(05)71113-5.

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3

Vakil, Anand Utpal, Maryam Ramezani, and Mary Beth B. Monroe. "Magnetically Actuated Shape Memory Polymers for On-Demand Drug Delivery." Materials 15, no. 20 (October 18, 2022): 7279. http://dx.doi.org/10.3390/ma15207279.

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Repeated use of intravenous infusions to deliver drugs can cause nerve damage, pain, and infection. There is an unmet need for a drug delivery method that administers drugs on demand for prolonged use. Here, we developed magnetically responsive shape memory polymers (SMPs) to enhance control over drug release. Iron oxide magnetic nanoparticles (mnps) were synthesized and incorporated into previously developed SMPs to enable magnetically induced shape memory effects that can be activated remotely via the application of an alternating magnetic field. These materials were tested for their shape memory properties (dynamic mechanical analysis), cytocompatibility (3T3 fibroblast viability), and tunable drug delivery rates (UV–VIS to evaluate the release of incorporated doxorubicin, 6-mercaptopurine, and/or rhodamine). All polymer composites had >75% cytocompatibility over 72 h. Altering the polymer chemistry and mnp content provided methods to tune drug release. Namely, linear polymers with higher mnp content had faster drug release. Highly cross-linked polymer networks with lower mnp content slowed drug release. Shape memory properties and polymer/drug interactions provided additional variables to tune drug delivery rates. Polymers that were fixed in a strained secondary shape had a slower release rate compared with unstrained polymers, and hydrophobic drugs were released more slowly than hydrophilic drugs. Using these design principles, a single material with gradient chemistry and dual drug loading was synthesized, which provided a unique mechanism to deliver two drugs from a single scaffold with distinct delivery profiles. This system could be employed in future work to provide controlled release of selected drug combinations with enhanced control over release as compared with previous approaches.

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4

Singh, Baljinder, Kibeom Kim, and Myoung-Hwan Park. "On-Demand Drug Delivery Systems Using Nanofibers." Nanomaterials 11, no. 12 (December 16, 2021): 3411. http://dx.doi.org/10.3390/nano11123411.

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On-demand drug-delivery systems using nanofibers are extensively applicable for customized drug release based on target location and timing to achieve the desired therapeutic effects. A nanofiber formulation is typically created for a certain medication and changing the drug may have a significant impact on the release kinetics from the same delivery system. Nanofibers have several distinguishing features and properties, including the ease with which they may be manufactured, the variety of materials appropriate for processing into fibers, a large surface area, and a complex pore structure. Nanofibers with effective drug-loading capabilities, controllable release, and high stability have gained the interest of researchers owing to their potential applications in on-demand drug delivery systems. Based on their composition and drug-release characteristics, we review the numerous types of nanofibers from the most recent accessible studies. Nanofibers are classified based on their mechanism of drug release, as well as their structure and content. To achieve controlled drug release, a suitable polymer, large surface-to-volume ratio, and high porosity of the nanofiber mesh are necessary. The properties of nanofibers for modified drug release are categorized here as protracted, stimulus-activated, and biphasic. Swellable or degradable polymers are commonly utilized to alter drug release. In addition to the polymer used, the process and ambient conditions can have considerable impacts on the release characteristics of the nanofibers. The formulation of nanofibers is highly complicated and depends on many variables; nevertheless, numerous options are available to accomplish the desired nanofiber drug-release characteristics.

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5

Gupta, R. K., F. Mirza, M. U. F. Khan, and J. Esquivel. "Aluminum containing Na2CrO4: Inhibitor release on demand." Materials Letters 205 (October 2017): 194–97. http://dx.doi.org/10.1016/j.matlet.2017.06.080.

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6

Wang, Joseph. "On-Demand Electrochemical Release of Nucleic Acids." Electroanalysis 13, no. 8-9 (May 2001): 635–38. http://dx.doi.org/10.1002/1521-4109(200105)13:8/9<635::aid-elan635>3.0.co;2-j.

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7

Chen, Menglin, Yan-Fang Li, and Flemming Besenbacher. "Electrospun Nanofibers-Mediated On-Demand Drug Release." Advanced Healthcare Materials 3, no. 11 (May 30, 2014): 1721–32. http://dx.doi.org/10.1002/adhm.201400166.

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8

Fallahi, Hedieh, Haotian Cha, Hossein Adelnia, Yuchen Dai, Hang Thu Ta, Sharda Yadav, Jun Zhang, and Nam-Trung Nguyen. "On-demand deterministic release of particles and cells using stretchable microfluidics." Nanoscale Horizons 7, no. 4 (2022): 414–24. http://dx.doi.org/10.1039/d1nh00679g.

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This paper reports a stretchable microfluidic cell trapper for the on-demand release of particles and cells in a deterministic manner. The size of particles to be trapped and released can be tuned by stretching the device.

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9

Eslami, Parisa, Martin Albino, Francesca Scavone, Federica Chiellini, Andrea Morelli, Giovanni Baldi, Laura Cappiello, et al. "Smart Magnetic Nanocarriers for Multi-Stimuli On-Demand Drug Delivery." Nanomaterials 12, no. 3 (January 18, 2022): 303. http://dx.doi.org/10.3390/nano12030303.

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In this study, we report the realization of drug-loaded smart magnetic nanocarriers constituted by superparamagnetic iron oxide nanoparticles encapsulated in a dual pH- and temperature-responsive poly (N-vinylcaprolactam-co-acrylic acid) copolymer to achieve highly controlled drug release and localized magnetic hyperthermia. The magnetic core was constituted by flower-like magnetite nanoparticles with a size of 16.4 nm prepared by the polyol approach, with good saturation magnetization and a high specific absorption rate. The core was encapsulated in poly (N-vinylcaprolactam-co-acrylic acid) obtaining magnetic nanocarriers that revealed reversible hydration/dehydration transition at the acidic condition and/or at temperatures above physiological body temperature, which can be triggered by magnetic hyperthermia. The efficacy of the system was proved by loading doxorubicin with very high encapsulation efficiency (>96.0%) at neutral pH. The double pH- and temperature-responsive nature of the magnetic nanocarriers facilitated a burst, almost complete release of the drug at acidic pH under hyperthermia conditions, while a negligible amount of doxorubicin was released at physiological body temperature at neutral pH, confirming that in addition to pH variation, drug release can be improved by hyperthermia treatment. These results suggest this multi-stimuli-sensitive nanoplatform is a promising candidate for remote-controlled drug release in combination with magnetic hyperthermia for cancer treatment.

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10

Onuora, Sarah. "Implanted ‘smart’ cells release biologic drugs on demand." Nature Reviews Rheumatology 17, no. 11 (September 29, 2021): 643. http://dx.doi.org/10.1038/s41584-021-00705-z.

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11

Azagarsamy, Malar A., Daniel L. Alge, Srinidhi J. Radhakrishnan, Mark W. Tibbitt, and Kristi S. Anseth. "Photocontrolled Nanoparticles for On-Demand Release of Proteins." Biomacromolecules 13, no. 8 (July 10, 2012): 2219–24. http://dx.doi.org/10.1021/bm300646q.

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12

Notman, Nina. "Lighting the way to on-demand drug release." Materials Today 17, no. 5 (June 2014): 211. http://dx.doi.org/10.1016/j.mattod.2014.04.041.

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13

De Smedt, Stefaan. "Release on demand: Artificial insemination by ovulation-triggered release of implanted sperms." Journal of Controlled Release 150, no. 1 (February 28, 2011): 1. http://dx.doi.org/10.1016/j.jconrel.2011.01.019.

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14

Jiang, Jianwei, Shaojuan Liu, Chunlei Wang, and Hongyan Zhang. "Overcoming Multidrug Resistance by On-Demand Intracellular Release of Doxorubicin and Verapamil." Journal of Nanomaterials 2018 (May 31, 2018): 1–7. http://dx.doi.org/10.1155/2018/3568190.

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Multidrug resistance (MDR) is one of the major obstacles to the successful application of cancer chemotherapy. Herein, we developed light-responsive doxorubicin-and-verapamil-coencapsulated gold liposomes to overcome MDR. Upon ns-pulsed laser irradiation, the highly confined thermal effect increased the permeability of the phospholipid bilayer, triggering the release of doxorubicin and verapamil, leading to high concentrations in cells. Free verapamil efficiently inhibited the membrane multidrug resistance proteins (MRPs), while the high concentration of doxorubicin saturated MRPs, thus overcoming MDR. We showed that nanosecond- (ns-) pulsed laser- (532 nm, 6 ns) induced doxorubicin release from gold liposomes depended on laser fluence and pulse number. More than 58% of the doxorubicin was released with a 10-pulse irradiation (100 mJ/cm2). Furthermore, ns laser pulses also liberated doxorubicin from endocytosed gold liposomes into the cytosol in MDA-MB-231-R cancer cells. The cytotoxicity of doxorubicin coencapsulated with verapamil was significantly enhanced upon laser irradiation. This study suggested that light-triggered on-demand release of chemotherapeutic agents and MRP inhibitors could be used advantageously to overcome multidrug resistance.

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15

Lin, Feng, Long Chen, Heng Zhang, William Shu Ching Ngai, Xiangmei Zeng, Jian Lin, and Peng R. Chen. "Bioorthogonal Prodrug–Antibody Conjugates for On-Target and On-Demand Chemotherapy." CCS Chemistry 1, no. 2 (June 2019): 226–36. http://dx.doi.org/10.31635/ccschem.019.20180038.

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Current antibody–drug conjugates (ADCs) suffer from low tissue penetration and significant side effects, largely due to the permanent linkage and/or premature release of cytotoxic payloads. Herein, we developed a prodrug–antibody conjugate (ProADC) strategy by conjugating a bioorthogonal-activatable prodrug with an antibody that allowed on-target release and on-demand activation of cytotoxic drugs at a tumor site. The bioorthogonal-caged prodrug exhibited an enhanced permeability into and on-demand activation within cancer cells, while the pH-sensitive ADC linker allowed on-target release of the anticancer agent. Together, the ProADCs showed enhanced tumor penetration and alleviated side effects for use as an on-target and on-demand chemotherapy agents.

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16

Yi, Y. T., J. Y. Sun, Y. W. Lu, and Y. C. Liao. "Programmable and on-demand drug release using electrical stimulation." Biomicrofluidics 9, no. 2 (March 2015): 022401. http://dx.doi.org/10.1063/1.4915607.

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17

Wang, Joseph, Mian Jiang, and Baidehi Mukherjee. "On-demand electrochemical release of DNA from gold surfaces." Bioelectrochemistry 52, no. 1 (September 2000): 111–14. http://dx.doi.org/10.1016/s0302-4598(00)00081-7.

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18

Venkatesh, Siddarth, Jacek Wower, and Mark E. Byrne. "Nucleic Acid Therapeutic Carriers with On-Demand Triggered Release." Bioconjugate Chemistry 20, no. 9 (September 16, 2009): 1773–82. http://dx.doi.org/10.1021/bc900187b.

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19

Amarjargal, Altangerel, Marzia Brunelli, Giuseppino Fortunato, Fabrizio Spano, Cheol Sang Kim, and René M. Rossi. "On-demand drug release from tailored blended electrospun nanofibers." Journal of Drug Delivery Science and Technology 52 (August 2019): 8–14. http://dx.doi.org/10.1016/j.jddst.2019.04.004.

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20

Wang, Wei, Chun Yang, YingShuai Liu, and Chang Ming Li. "On-demand droplet release for droplet-based microfluidic system." Lab on a Chip 10, no. 5 (2010): 559. http://dx.doi.org/10.1039/b924929j.

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21

Dyer, C. "Doctors demand release of postmortem findings on David Kelly." BMJ 340, jan29 1 (January 29, 2010): c577. http://dx.doi.org/10.1136/bmj.c577.

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22

Tuncaboylu, Deniz Ceylan, Fabian Friess, Christian Wischke, and Andreas Lendlein. "A multifunctional multimaterial system for on-demand protein release." Journal of Controlled Release 284 (August 2018): 240–47. http://dx.doi.org/10.1016/j.jconrel.2018.06.022.

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23

Davoodi, Pooya, Lai Yeng Lee, Qingxing Xu, Vishnu Sunil, Yajuan Sun, Siowling Soh, and Chi-Hwa Wang. "Drug delivery systems for programmed and on-demand release." Advanced Drug Delivery Reviews 132 (July 2018): 104–38. http://dx.doi.org/10.1016/j.addr.2018.07.002.

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24

Katagiri, Kiyofumi, Yuji Imai, and Kunihito Koumoto. "Variable on-demand release function of magnetoresponsive hybrid capsules." Journal of Colloid and Interface Science 361, no. 1 (September 2011): 109–14. http://dx.doi.org/10.1016/j.jcis.2011.05.035.

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25

Gelebart, Anne Helene, Danqing Liu, Dirk J. Mulder, Kevin H. J. Leunissen, Jop van Gerven, Albert P. H. J. Schenning, and Dirk J. Broer. "Photoresponsive Sponge-Like Coating for On-Demand Liquid Release." Advanced Functional Materials 28, no. 10 (January 29, 2018): 1705942. http://dx.doi.org/10.1002/adfm.201705942.

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26

Park, Tae-Hong, Thomas W. Eyster, Joshua M. Lumley, Sangyeul Hwang, Kyung Jin Lee, Asish Misra, Sahar Rahmani, and Joerg Lahann. "Photoswitchable Particles for On-Demand Degradation and Triggered Release." Small 9, no. 18 (April 19, 2013): 3051–57. http://dx.doi.org/10.1002/smll.201201921.

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27

Zhao, Xuanhe, Jaeyun Kim, Christine A. Cezar, Nathaniel Huebsch, Kangwon Lee, Kamal Bouhadir, and David J. Mooney. "Active scaffolds for on-demand drug and cell delivery." Proceedings of the National Academy of Sciences 108, no. 1 (December 13, 2010): 67–72. http://dx.doi.org/10.1073/pnas.1007862108.

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Porous biomaterials have been widely used as scaffolds in tissue engineering and cell-based therapies. The release of biological agents from conventional porous scaffolds is typically governed by molecular diffusion, material degradation, and cell migration, which do not allow for dynamic external regulation. We present a new active porous scaffold that can be remotely controlled by a magnetic field to deliver various biological agents on demand. The active porous scaffold, in the form of a macroporous ferrogel, gives a large deformation and volume change of over 70% under a moderate magnetic field. The deformation and volume variation allows a new mechanism to trigger and enhance the release of various drugs including mitoxantrone, plasmid DNA, and a chemokine from the scaffold. The porous scaffold can also act as a depot of various cells, whose release can be controlled by external magnetic fields.

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28

Nguyen, Dung The, Nguyet-Minh Nguyen, Duc-Minh Vu, Minh-Duc Tran, and Van-Thao Ta. "On-Demand Release of Drug from Magnetic Nanoparticle-Loaded Alginate Beads." Journal of Analytical Methods in Chemistry 2021 (April 2, 2021): 1–7. http://dx.doi.org/10.1155/2021/5576283.

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Targeted delivery and controlled release of drugs has been considered to be an important therapeutic approach since it could allow a better treatment efficiency and less side effects. In this research, magnetite Fe3O4 nanoparticles were successfully synthesized via the coprecipitation method and then loaded in alginate beads with berberine as a drug model for drug release application. Various factors such as pH values of the suspended environment and surface modifications of the drug carrier could be exploited to adjust the amount of drug release. More importantly, the amount of drug release could be effectively controlled by an on-off switching operation of a static magnetic field.

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29

Chen, Yijun, James G. Boyd, and Mohammad Naraghi. "Encapsulation and on-demand release of functional materials from conductive nanofibers via electrical signals." Multifunctional Materials 5, no. 1 (February 14, 2022): 015003. http://dx.doi.org/10.1088/2399-7532/ac4fb8.

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Abstract The goal of this research is to establish a highly compact on-demand release platform for functional materials where porous nanofibers serve as the host, heat-based release trigger and temperature controller for regulated release. The ability to store functional materials in fibers and release them on demand via external signals may open up new frontiers in areas such as smart textiles and autonomous composites. The host material was porous carbon nanofibers (CNFs), which encapsulated functional materials, protected by a thin polymeric coating to thermally regulate the release. This platform was used to store Gentian violet (GV), an antibacterial material, and release it with highly controllable rates in aqueous environment. The high porosity of the CNF yarns, both inter- and intra-fiber porosity, resulted in a mass loading of as high as ∼50 wt%. The active release was triggered via passing electrical signals through CNF yarn backbone, thereby heating the coating. The rate of release as a function of temperature was measured. It was concluded that the release mechanism is via thermally augmented and reversible diffusion rates of GV and water through the coating. By applying electric current, the diffusion coefficient of the coating was increased, and the release rate dramatically increased in a reversible fashion by as much as 39×.

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30

Epley, Charity C., Kristina L. Roth, Shaoyang Lin, Spencer R. Ahrenholtz, Tijana Z. Grove, and Amanda J. Morris. "Cargo delivery on demand from photodegradable MOF nano-cages." Dalton Transactions 46, no. 15 (2017): 4917–22. http://dx.doi.org/10.1039/c6dt04787d.

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31

Samanta, Devleena, Rohan Mehrotra, Katy Margulis, and Richard N. Zare. "On-demand electrically controlled drug release from resorbable nanocomposite films." Nanoscale 9, no. 42 (2017): 16429–36. http://dx.doi.org/10.1039/c7nr06443h.

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32

Vertommen, Micky A. M. E., Henk-Jan L. Cornelissen, Carin H. J. T. Dietz, Richard Hoogenboom, Maartje F. Kemmere, and Jos T. F. Keurentjes. "Pore-covered thermoresponsive membranes for repeated on-demand drug release." Journal of Membrane Science 322, no. 1 (September 2008): 243–48. http://dx.doi.org/10.1016/j.memsci.2008.05.044.

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33

Seo, Yongbeom, Jiayu Leong, Jye Yng Teo, Jennifer W. Mitchell, Martha U. Gillette, Bumsoo Han, Jonghwi Lee, and Hyunjoon Kong. "Active Antioxidizing Particles for On-Demand Pressure-Driven Molecular Release." ACS Applied Materials & Interfaces 9, no. 41 (October 9, 2017): 35642–50. http://dx.doi.org/10.1021/acsami.7b12297.

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34

Deok Kong, Seong, Weizhou Zhang, Jun Hee Lee, Chulmin Choi, Jirapon Khamwannah, Michael Karin, and Sungho Jin. "Externally triggered on-demand drug release and deep tumor penetration." Journal of Vacuum Science & Technology B, Nanotechnology and Microelectronics: Materials, Processing, Measurement, and Phenomena 30, no. 2 (March 2012): 02C102. http://dx.doi.org/10.1116/1.3694833.

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35

Ribovski, Laís, Qihui Zhou, Jiawen Chen, Ben L. Feringa, Patrick van Rijn, and Inge S. Zuhorn. "Light-induced molecular rotation triggers on-demand release from liposomes." Chemical Communications 56, no. 62 (2020): 8774–77. http://dx.doi.org/10.1039/d0cc02499f.

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36

Aschkenasy, Chaim, and Joseph Kost. "On-demand release by ultrasound from osmotically swollen hydrophobic matrices." Journal of Controlled Release 110, no. 1 (December 2005): 58–66. http://dx.doi.org/10.1016/j.jconrel.2005.09.025.

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37

Zhang, Yanfeng, Qian Yin, Lichen Yin, Liang Ma, Li Tang, and Jianjun Cheng. "Chain-Shattering Polymeric Therapeutics with On-Demand Drug-Release Capability." Angewandte Chemie 125, no. 25 (May 6, 2013): 6563–67. http://dx.doi.org/10.1002/ange.201300497.

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38

Zhang, Yanfeng, Qian Yin, Lichen Yin, Liang Ma, Li Tang, and Jianjun Cheng. "Chain-Shattering Polymeric Therapeutics with On-Demand Drug-Release Capability." Angewandte Chemie International Edition 52, no. 25 (May 6, 2013): 6435–39. http://dx.doi.org/10.1002/anie.201300497.

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39

Akash, Shahrukh Zaman, Farjana Yesmin Lucky, Murad Hossain, Asim Kumar Bepari, G. M. Sayedur Rahman, Hasan Mahmud Reza, and Shazid Md Sharker. "Remote Temperature-Responsive Parafilm Dermal Patch for On-Demand Topical Drug Delivery." Micromachines 12, no. 8 (August 18, 2021): 975. http://dx.doi.org/10.3390/mi12080975.

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The development of externally controlled drug delivery systems that can rapidly trigger drug release is widely expected to change the landscape of future drug carriers. In this study, a drug delivery system was developed for on-demand therapeutic effects. The thermoresponsive paraffin film can be loaded on the basis of therapeutic need, including local anesthetic (lidocaine) or topical antibiotic (neomycin), controlled remotely by a portable mini-heater. The application of mild temperature (45 °C) to the drug-loaded paraffin film allowed a rapid stimulus response within a short time (5 min). This system exploits regular drug release and the rapid generation of mild heat to trigger a burst release of 80% within 6 h of any locally administered drug. The in vitro drug release studies and in vivo therapeutic activity were observed for local anesthesia and wound healing using a neomycin-loaded film. The studies demonstrated on-demand drug release with minimized inflammation and microbial infection. This temperature-responsive drug-loaded film can be triggered remotely to provide flexible control of dose magnitude and timing. Our preclinical studies on these remotely adjustable drug delivery systems can significantly improve patient compliance and medical practice.

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40

Takeda, Shuntaro, Kan Takase, and Akira Furusawa. "On-demand photonic entanglement synthesizer." Science Advances 5, no. 5 (May 2019): eaaw4530. http://dx.doi.org/10.1126/sciadv.aaw4530.

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Quantum information protocols require various types of entanglement, such as Einstein-Podolsky-Rosen, Greenberger-Horne-Zeilinger, and cluster states. In optics, on-demand preparation of these states has been realized by squeezed light sources, but such experiments require different optical circuits for different entangled states, thus lacking versatility. Here, we demonstrate an on-demand entanglement synthesizer that programmably generates all these entangled states from a single squeezed light source. This is achieved by a loop-based circuit that is dynamically controllable at nanosecond time scales and processes optical pulses in the time domain. We verify the generation of five different small-scale entangled states and a large-scale cluster state containing more than 1000 modes without changing the optical circuit. Moreover, this circuit enables storage and release of one part of the generated entangled state, thus working as a quantum memory. Our demonstration should open a way for a more general entanglement synthesizer and a scalable quantum processor.

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41

Xiang, Li, Gulsu Sener, and Adem Yildirim. "Abstract 5751: Ultrasound responsive injectable hydrogels for on-demand drug delivery." Cancer Research 84, no. 6_Supplement (March 22, 2024): 5751. http://dx.doi.org/10.1158/1538-7445.am2024-5751.

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Abstract In this work, we developed ultrasound-responsive and injectable hydrogels for local and on-demand release of chemotherapeutics to solid tumors. Injectable hydrogels were prepared by using a zwitterionic monomer, sulfobetaine methacrylate (SBMA), without using any crosslinker. Gelation was performed at -20 oC using APS/TEMED as initiator, allowing the formation of strong electrostatic interactions between poly(SBMA) chains to physically crosslink the hydrogels. Monomer and initiator concentrations were carefully optimized to achieve injectable hydrogels with mechanical and thermal stability. To render ultrasound responsivity to the hydrogels, we loaded the hydrogels with hydrophobically (dodecyl) modified mesoporous silica nanoparticles (hMSNs) with sizes around 50 nm. When insonated with low-intensity focused ultrasound (LIUS), the hMSNs incept acoustic cavitation (i.e., growth and collapse of microsized bubbles), which in turn generates mechanical effects in the hydrogels such as shock waves or water jets. We found that loading the hydrogels with hMSN did not affect their injectability, and they remained mechanically stable at 37 °C for more than a week. hMSN-loaded hydrogels demonstrated strong ultrasound responsivity even at low particle concentrations (0.1 mg/mL) and ultrasound powers (25 W, 0.02% duty cycle). Finally, we loaded the hydrogels with a chemotherapy drug, doxorubicin (DOX, 0.2 mg/mL). DOX-loaded hydrogels demonstrated minimal release without LIUS treatment (<20% in a day). Application of LIUS (150 W, 1% duty cycle) for 5 min resulted in almost complete mechanical disintegration of the hydrogels, resulting in a burst DOX release. We also showed that the amount of released DOX could be controlled by tuning the LUIS power and its duration. In summary, we developed injectable hydrogels with strong ultrasound responsivity. These hydrogels hold great promise for local and on-demand drug delivery to solid tumors, which is currently under investigation in our laboratory. Citation Format: Li Xiang, Gulsu Sener, Adem Yildirim. Ultrasound responsive injectable hydrogels for on-demand drug delivery [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 5751.

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42

Sprague, Randy S., Daniel Goldman, Elizabeth A. Bowles, David Achilleus, Alan H. Stephenson, Christopher G. Ellis, and Mary L. Ellsworth. "Divergent effects of low-O2 tension and iloprost on ATP release from erythrocytes of humans with type 2 diabetes: implications for O2 supply to skeletal muscle." American Journal of Physiology-Heart and Circulatory Physiology 299, no. 2 (August 2010): H566—H573. http://dx.doi.org/10.1152/ajpheart.00430.2010.

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Erythrocytes release both O2 and a vasodilator, ATP, when exposed to reduced O2 tension. We investigated the hypothesis that ATP release is impaired in erythrocytes of humans with type 2 diabetes (DM2) and that this defect compromises the ability of these cells to stimulate dilation of resistance vessels. We also determined whether a general vasodilator, the prostacyclin analog iloprost (ILO), stimulates ATP release from healthy human (HH) and DM2 erythrocytes. Finally, we used a computational model to compare the effect on tissue O2 levels of increases in blood flow directed to areas of increased O2 demand (erythrocyte ATP release) with nondirected increases in flow (ILO). HH erythrocytes, but not DM2 cells, released increased amounts of ATP when exposed to reduced O2 tension (Po2 < 30 mmHg). In addition, isolated hamster skeletal muscle arterioles dilated in response to similar decreases in extraluminal O2 when perfused with HH erythrocytes, but not when perfused with DM2 erythrocytes. In contrast, both HH and DM2 erythrocytes released ATP in response to ILO. In the case of DM2 erythrocytes, amounts of ATP released correlated inversely with glycemic control. Modeling revealed that a functional regulatory system that directs blood flow to areas of need (low O2-induced ATP release) provides appropriate levels of tissue oxygenation and that this level of the matching of O2 delivery with demand in skeletal muscle cannot be achieved with a general vasodilator. These results suggest that the inability of erythrocytes to release ATP in response to exposure to low-O2 tension could contribute to the peripheral vascular disease of DM2.

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43

Wang, Xiuxia, Liping Huang, Yiwei Zhang, Fanling Meng, Maria Donoso, Roy Haskell, and Liang Luo. "Tunable Two-Compartment On-Demand Sustained Drug Release Based on Lipid Gels." Journal of Pharmaceutical Sciences 109, no. 2 (February 2020): 1059–67. http://dx.doi.org/10.1016/j.xphs.2019.10.021.

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44

Leganés Bayón, Jorge, Ana Sánchez‐Migallón, Ángel Díaz‐Ortiz, Carlos Alberto Castillo, Inma Ballesteros‐Yáñez, Sonia Merino, and Ester Vázquez. "On‐Demand Hydrophobic Drug Release Based on Microwave‐Responsive Graphene Hydrogel Scaffolds." Chemistry – A European Journal 26, no. 71 (November 30, 2020): 17069–80. http://dx.doi.org/10.1002/chem.202001429.

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45

Zhao, Zheng, Jodi McGill, Pamela Gamero-Kubota, and Mei He. "Microfluidic on-demand engineering of exosomes towards cancer immunotherapy." Lab on a Chip 19, no. 10 (2019): 1877–86. http://dx.doi.org/10.1039/c8lc01279b.

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3D printing-based facile microfabrication of a microfluidic culture chip integrates harvesting, antigenic modification, and photo-release of surface engineered exosomes in one workflow, which enables rapid and real-time production of therapeutic exosomes for advancing cancer immunotherapy.

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46

Boulahneche, Samia, Roxana Jijie, Alexandre Barras, Fereshteh Chekin, Santosh K. Singh, Julie Bouckaert, Mohamed Salah Medjram, Sreekumar Kurungot, Rabah Boukherroub, and Sabine Szunerits. "On demand electrochemical release of drugs from porous reduced graphene oxide modified flexible electrodes." Journal of Materials Chemistry B 5, no. 32 (2017): 6557–65. http://dx.doi.org/10.1039/c7tb00687j.

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Wang, Max L., Christian F. Chamberlayne, Haixia Xu, Mohammad Mofidfar, Spyridon Baltsavias, Justin P. Annes, Richard N. Zare, and Amin Arbabian. "On-demand electrochemically controlled compound release from an ultrasonically powered implant." RSC Advances 12, no. 36 (2022): 23337–45. http://dx.doi.org/10.1039/d2ra03422k.

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48

Cao, Yanwu, Min Gao, Chao Chen, Aiping Fan, Ju Zhang, Deling Kong, Zheng Wang, Dan Peer, and Yanjun Zhao. "Triggered-release polymeric conjugate micelles for on-demand intracellular drug delivery." Nanotechnology 26, no. 11 (February 24, 2015): 115101. http://dx.doi.org/10.1088/0957-4484/26/11/115101.

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Ji, Xingyue, Zhixiang Pan, Bingchen Yu, Ladie Kimberly De La Cruz, Yueqin Zheng, Bowen Ke, and Binghe Wang. "Click and release: bioorthogonal approaches to “on-demand” activation of prodrugs." Chemical Society Reviews 48, no. 4 (2019): 1077–94. http://dx.doi.org/10.1039/c8cs00395e.

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Jeong, Woong-Chan, Shin-Hyun Kim, and Seung-Man Yang. "Photothermal Control of Membrane Permeability of Microcapsules for On-Demand Release." ACS Applied Materials & Interfaces 6, no. 2 (January 6, 2014): 826–32. http://dx.doi.org/10.1021/am4037993.

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