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Dissertations / Theses on the topic 'OMIEC'

Author: Grafiati

Published: 29 June 2021

Last updated: 29 July 2025

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1

Heimonen, Johanna. "Synthesis of a polar conjugated polythiophene for 3D-printing of complex coacervates." Thesis, Linköpings universitet, Laboratoriet för organisk elektronik, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-177396.

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The aim of this thesis was to synthesize a functionalized polar conjugated polythiophene that could be (3D-) printed into form-stable structures for bio-interfacing. The material design rationale aimed for a water-processable polymer that had the capability of electronic and ionic conduction, by using a thiophene backbone and oligoethylene side chains. Functionalization of the oligoethylene side chains with carboxylate groups created a polyanion, which allowed for a bio-inspired approach to combine printability and form-stability through formation of complex coacervates. The synthesis of the c

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2

Donate, Puertas Rosa. "Omic approach to atrial fibrillation." Thesis, Lyon, 2017. http://www.theses.fr/2017LYSE1164.

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La fibrillation atriale (FA) est un problème de santé publique majeur dans le monde entier. Le remodelage électrique, structurel et neuronal est sous-jacent à la myopathie atriale. La pharmacothérapie actuelle est souvent inefficace en raison du manque de connaissance de la pathophysiologie de la FA.Pour comprendre comment se réalise le remodelage atrial, une approche Omique qui explore le transcriptome, l'épigénome (méthylome et microOme) et le génome de patients atteints de FA a été réalisée. Parallèlement, le phénotype de vieux rats spontanément hypertendus (SHRs) a été caractérisé et une é

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3

Bilbrey, Emma A. "Seeding Multi-omic Improvement of Apple." The Ohio State University, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=osu1594907111820227.

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4

Guan, Xiaowei. "Bioinformatics Approaches to Heterogeneous Omic Data Integration." Case Western Reserve University School of Graduate Studies / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=case1340302883.

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5

Cason, Marco. "Application of omic technologies in Arrhythmogenic Cardiomyopathy." Doctoral thesis, Università degli studi di Padova, 2018. http://hdl.handle.net/11577/3427282.

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Background. Arrhythmogenic cardiomyopathy (AC) is an inherited myocardial disease characterized by fibro-fatty replacement of the myocardium and life-threatening arrhythmias. This genetically and phenotypically heterogeneous condition, caused mainly by mutations in desmosomal genes (JUP, DSP, PKP2, DSG2 and DSC2), exhibits reduced penetrance making challenging the diagnosis and the identification of a molecular mechanism underlying disease pathogenesis. Aims. (1) To identify one or more altered molecular pathways in AC carriers of desmosomal mutations; (2) to evaluate the diagnostic role of J

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6

Xiao, Hui. "Network-based approaches for multi-omic data integration." Thesis, University of Cambridge, 2019. https://www.repository.cam.ac.uk/handle/1810/289716.

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The advent of advanced high-throughput biological technologies provides opportunities to measure the whole genome at different molecular levels in biological systems, which produces different types of omic data such as genome, epigenome, transcriptome, translatome, proteome, metabolome and interactome. Biological systems are highly dynamic and complex mechanisms which involve not only the within-level functionality but also the between-level regulation. In order to uncover the complexity of biological systems, it is desirable to integrate multi-omic data to transform the multiple level data in

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7

Rossouw, Debra. "Comparative 'omic' profiling of industrial wine yeast strains." Thesis, Stellenbosch : University of Stellenbosch, 2009. http://hdl.handle.net/10019.1/1454.

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Thesis (PhD(Agric) Viticulture and Oenology. Wine Biotechnology))--University of Stellenbosch, 2009.<br>The main goal of this project was to elucidate the underlying genetic factors responsible for the different fermentation phenotypes and physiological adaptations of industrial wine yeast strains. To address this problem an ‘omic’ approach was pursued: Five industrial wine yeast strains, namely VIN13, EC1118, BM45, 285 and DV10, were subjected to transcriptional, proteomic and exometabolomic profiling during alcoholic fermentation in simulated wine-making conditions. The aim was to evalu

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8

Baldazzi, Davide <1993&gt. "Methods for Biodata Analysis in different Omic Contexts." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2022. http://amsdottorato.unibo.it/10076/3/Phd-Thesis_Baldazzi-Davide_27Jan2022.pdf.

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The world of Computational Biology and Bioinformatics presently integrates many different expertise, including computer science and electronic engineering. A major aim in Data Science is the development and tuning of specific computational approaches to interpret the complexity of Biology. Molecular biologists and medical doctors heavily rely on an interdisciplinary expert capable of understanding the biological background to apply algorithms for finding optimal solutions to their problems. With this problem-solving orientation, I was involved in two basic research fields: Cancer Genomics and

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9

DENTI, VANNA. "Development of multi-omic mass spectrometry imaging approaches to assist clinical investigations." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2022. http://hdl.handle.net/10281/365169.

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Con il termine di –omica spaziale si intende l’insieme di diverse tecniche che consentono di rilevare alterazioni significative delle biomolecole all’interno dei loro tessuti d’origine o delle strutture cellulari, permettendo quindi di integrare ed ampliare la comprensione dei cambiamenti biologici che si verificano in tessuti patologici complessi ed eterogenei, come il cancro. Tuttavia, per comprendere appieno la complessità e le dinamiche al di là delle condizioni patologiche, è necessario studiare e integrare diverse analisi molecolari, come quelle di lipidi e glicani, in modo da ottenere u

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10

Martínez, Enguita David. "Identification of personalized multi-omic disease modules in asthma." Thesis, Högskolan i Skövde, Institutionen för biovetenskap, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-15987.

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Asthma is a respiratory syndrome associated with airflow limitation, bronchial hyperresponsiveness and inflammation of the airways in the lungs. Despite the ongoing research efforts, the outstanding heterogeneity displayed by the multiple forms in which this condition presents often hampers the attempts to determine and classify the phenotypic and endotypic biological structures at play, even when considering a limited assembly of asthmatic subjects. To increase our understanding of the molecular mechanisms and functional pathways that govern asthma from a systems medicine perspective, a compu

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11

Zuo, Yiming. "Differential Network Analysis based on Omic Data for Cancer Biomarker Discovery." Diss., Virginia Tech, 2017. http://hdl.handle.net/10919/78217.

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Recent advances in high-throughput technique enables the generation of a large amount of omic data such as genomics, transcriptomics, proteomics, metabolomics, glycomics etc. Typically, differential expression analysis (e.g., student's t-test, ANOVA) is performed to identify biomolecules (e.g., genes, proteins, metabolites, glycans) with significant changes on individual level between biologically disparate groups (disease cases vs. healthy controls) for cancer biomarker discovery. However, differential expression analysis on independent studies for the same clinical types of patients often le

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12

Tsai, Tsung-Heng. "Bayesian Alignment Model for Analysis of LC-MS-based Omic Data." Diss., Virginia Tech, 2014. http://hdl.handle.net/10919/64151.

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Liquid chromatography coupled with mass spectrometry (LC-MS) has been widely used in various omic studies for biomarker discovery. Appropriate LC-MS data preprocessing steps are needed to detect true differences between biological groups. Retention time alignment is one of the most important yet challenging preprocessing steps, in order to ensure that ion intensity measurements among multiple LC-MS runs are comparable. In this dissertation, we propose a Bayesian alignment model (BAM) for analysis of LC-MS data. BAM uses Markov chain Monte Carlo (MCMC) methods to draw inference on the model par

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Ruffalo, Matthew M. "Algorithms for Constructing Features for Integrated Analysis of Disparate Omic Data." Case Western Reserve University School of Graduate Studies / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=case1449238712.

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14

Elhezzani, Najla Saad R. "New statistical methodologies for improved analysis of genomic and omic data." Thesis, King's College London (University of London), 2018. https://kclpure.kcl.ac.uk/portal/en/theses/new-statistical-methodologies-for-improved-analysis-of-genomic-and-omic-data(eb8d95f4-e926-4c54-984f-94d86306525a).html.

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We develop statistical tools for analyzing different types of phenotypic data in genome-wide settings. When the phenotype of interest is a binary case-control status, most genome-wide association studies (GWASs) use randomly selected samples from the population (hereafter bases) as the control set. This approach is successful when the trait of interest is very rare; otherwise, a loss in the statistical power to detect disease-associated variants is expected. To address this, we propose a joint analysis of the three types of samples; cases, bases and controls. This is done by modeling the bases

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15

Elsheikh, Samar Salah Mohamedahmed. "Integration of multi-omic data and neuroimaging characteristics in studying brain related diseases." Doctoral thesis, Faculty of Health Sciences, 2020. http://hdl.handle.net/11427/32609.

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Approaches to the identification of genetic variants associated with complex brain diseases have evolved in recent decades. This evolution was supported by advancements in medical imaging and genotyping technologies that result in rich data production in the field of imaging genetics and radiogenomics. Studies in these fields have taken different designs and directions from genomewide associations to studying the complex interplay between genetics and structural connectivity of a wide range of brain-related diseases. Nevertheless, such combinations of heterogeneous, high dimensional and inter-

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16

Contreras, Jodar Alexandra. "The use of omic-methodologies in the assessment of heat-stressed lactating dairy goats." Doctoral thesis, Universitat Autònoma de Barcelona, 2019. http://hdl.handle.net/10803/667937.

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L’estrés per calor (EC) genera pèrdues significatives en l’industria lletera caprina quan l’índex de temperatura-humitat (THI) és > 75. Les tecnologies ‘òmiques’ ofereixen una perspectiva holística de com les cabres combaten l’EC i poden permetre trobar biomarcadors. Amb aquest objectiu, es van portar a terme 3 experiments (Exp.) utilitzant cabres lleteres Murciano-Granadines i una càmbra climàtica amb caixes metabòliques. Les cabres lleteres (n = 32) es van alimentar amb una ració total mesclada i es van munyir ⨯1 diàriament sota dos condicions climàtiques. Aquestes foren: TN (termo-neutralit

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17

Ehrenberger, Tobias. "Cancer systems biology : functional insights and therapeutic strategies for medulloblastoma from omic data integration." Thesis, Massachusetts Institute of Technology, 2019. https://hdl.handle.net/1721.1/123062.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Biological Engineering, 2019<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (pages 151-167).<br>Medulloblastoma (MB) is a chiefly pediatric cancer of the cerebellum that has been studied extensively using genomic, epigenomic, and transcriptomic data. It comprises at least four molecularly distinct subgroups: WNT, SHH, Group 3, and Group 4. Despite the detailed characterization of MB, many disease-driving events remain to be elucidated and therapeutic targets to be nominated. In this thesis, we

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18

Ciaccio, Roberto <1990&gt. "Multi-omic analyses of the MYCN network unveil new potential vulnerabilities in childhood neuroblastoma." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2021. http://amsdottorato.unibo.it/9930/1/PhD%20thesis%20Ciaccio%20Roberto_2021.pdf.

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Neuroblastoma is the first neurogenic-extracranial solid cancer occurring in infancy and childhood. The genetic aberration most commonly associated with a poor prognosis is MYCN gene’s amplification. We hypothesize that effective anti-MYC therapeutics can be developed by understanding the regulation and function of N-MYC in neuroblastoma. Since N-MYC is an intrinsically disordered protein, it is still challenging to target this transcription factor, however, the model is shifting significantly after discovering novel therapeutic targets that impact MYC-driven tumorigenesis. The following work

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19

Fuertes, Rodríguez Inmaculada. "Application of omic approaches on the mechanisms of pollutants using Daphnia magna as model species." Doctoral thesis, Universitat de Barcelona, 2021. http://hdl.handle.net/10803/671146.

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Environmental toxicology is undergoing a paradigm shift due to the new concerning environmental reality. Nowadays, to manage subtler and chronic effects of chemicals, either single or mixtures, is an imperative need, especially at low and environmentally relevant concentrations. Not least important is to deal with emerging contaminants (ECs), whose harmful effects in ecosystems and toxicity mechanisms are still unknown. Therefore, new strategies for assessing the toxicity of pollutants with greater environmental relevance must be developed, what req

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20

Forrester, S. J. "Using OMIC approaches to understand the genetic mechanisms controlling virulence in Trypanosoma brucei rhodesiense isolates." Thesis, University of Liverpool, 2016. http://livrepository.liverpool.ac.uk/3000023/.

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Due to the resurgence of human African trypanosomiasis (HAT), the world health organization (WHO) and various non-governmental organisations NGO’s have implemented strategies that have led to a significant drop in disease incidence, with only ~3,500 new HAT cases recorded in 2014. However the causative agent, T. brucei is still responsible for a heavy socio-economic burden, with T. brucei infections in cattle representing an estimated billion dollar loss annually. Of the two human infective T. brucei subspecies, T.b. rhodesiense is responsible for less than 3% of all HAT cases and is primarily

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21

Ciucci, Sara, Yan Ge, Claudio Durán, et al. "Enlightening discriminative network functional modules behind Principal Component Analysis separation in differential-omic science studies." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2017. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-226961.

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Omic science is rapidly growing and one of the most employed techniques to explore differential patterns in omic datasets is principal component analysis (PCA). However, a method to enlighten the network of omic features that mostly contribute to the sample separation obtained by PCA is missing. An alternative is to build correlation networks between univariately-selected significant omic features, but this neglects the multivariate unsupervised feature compression responsible for the PCA sample segregation. Biologists and medical researchers often prefer effective methods that offer an immedi

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22

Lingam, Shivanjali. "Multi-Omic Characterisation of the Kidney in a Rodent Model of Type Two Diabetes Mellitus." Thesis, University of Sydney, 2020. https://hdl.handle.net/2123/23717.

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Type 2 diabetes mellitus (T2DM) is the most rapidly growing disease worldwide, with a more than four-fold increase in diagnosed people in the last 30 years. Almost 500 million people are affected, and many more are thought to be undiagnosed. T2DM is a disorder of human metabolism resulting from the resistance of peripheral tissues to the hormone insulin, which is produced by the β-cells of the pancreas. Insulin regulates blood glucose levels and therefore insulin resistance can generate a profound hyperglycemia that itself has major health risks. T2DM is largely considered therefore to be a ‘l

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23

ZAMARIAN, VALENTINA. "IDENTIFICATION OF TUMOR-ASSOCIATED MOLECULES AS SUITABLE BIOMARKERS OF CANCER IN DOGS USING OMIC APPROACHES." Doctoral thesis, Università degli Studi di Milano, 2021. http://hdl.handle.net/2434/820372.

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Omics techniques have been widely applied to veterinary science, although mostly on farm animal productions and infectious diseases. In canine oncology, on the contrary, the use of omics methodologies is still far behind. This thesis aims to fill in the gap in the molecular background of canine cancer tumors and to apply this new knowledge for the identification of suitable biomarkers mainly based on the identification and quantification of microRNAs. The thesis applied next generation sequencing (NGS) to investigate onco-miRNome and skin microbiota of one of the most relevant, highly metastat

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Tuck, Michael. "Molecular characterization of tuberculosis by MALDI mass spectrometry - applications toward multi-omic and multimodal imaging." Electronic Thesis or Diss., Bordeaux, 2024. http://www.theses.fr/2024BORD0015.

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Cette thèse vise à relever le défi sanitaire urgent de la tuberculose (TB) par le développement d'une stratégie d'imagerie par spectrométrie de masse quantitative ou QMSI, en se concentrant spécifiquement sur les médicaments antiTB tels que la clofazimine (CFZ), la rifampicine (RIF), et l'éthambutol (ETM). TB, causée par Mycobacterium tuberculosis (Mtb), constitue une menace pour la santé mondiale, également renforcée par la résistance bactérienne, induisant la mise en place de lignes de thérapie basées sur l'utilisation d'un traitement adapté et plus efficace avec un panel d'antibiotiques épr

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25

Angione, Claudio. "Computational methods for multi-omic models of cell metabolism and their importance for theoretical computer science." Thesis, University of Cambridge, 2015. https://www.repository.cam.ac.uk/handle/1810/252943.

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To paraphrase Stan Ulam, a Polish mathematician who became a leading figure in the Manhattan Project, in this dissertation I focus not only on how computer science can help biologists, but also on how biology can inspire computer scientists. On one hand, computer science provides powerful abstraction tools for metabolic networks. Cell metabolism is the set of chemical reactions taking place in a cell, with the aim of maintaining the living state of the cell. Due to the intrinsic complexity of metabolic networks, predicting the phenotypic traits resulting from a given genotype and metabolic str

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26

Détrée, Camille. "Mise en évidence des acteurs moléculaires de la symbiose chimiosynthetique chez Bathymodiolus azoricus : une approche OMIC." Thesis, Paris 6, 2015. http://www.theses.fr/2015PA066575/document.

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L'importance des symbioses dans l'évolution du vivant est désormais admise et les associations symbiotiques sont observées dans une grande diversité d'habitats. Notre étude porte sur une symbiose au sein d'un écosystème réduit, les sources hydrothermales de l'océan profond. Bathymodiolus azoricus est un bivalve hydrothermal vivant le long de la ride Médio-Atlantique, qui héberge dans des cellules branchiales spécialisées, deux types de γ-protéobactéries différentes : des méthanotrophes (MOX) et des sulfo-oxydantes (SOX). Ces dernières sont capables d'oxyder les composés réduits présents dans l

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27

PISCIOTTANI, ALESSANDRA. "Axonal mRNA dysregulation in a cellular model of TDP-43 proteinopathy: a functional and -omic analysis." Doctoral thesis, Università Vita-Salute San Raffaele, 2022. http://hdl.handle.net/20.500.11768/128351.

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Amyotrophic lateral sclerosis (ALS) is an incurable neurodegenerative disease that mainly affects upper and lower motor neurons. Only 10% of cases are familial, while the majority are sporadic. TDP-43, encoded by the TARDBP gene, is an RNA-binding protein that plays essential regulatory roles in RNA metabolism, from transcription and splicing to transport and translation. While TARDBP mutations are only found in 2-5% of ALS cases, 97% of patients, both sporadic and familial, show nuclear TDP-43 depletion as well as its cytoplasmic accumulation and aggregate formation, known as TDP-43 protein

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28

Thavamani, Abhishek [Verfasser], and Alfred [Akademischer Betreuer] Nordheim. "Integrated multi-omic analysis of HCC formation in the SRF-VP16iHep mouse model / Abhishek Thavamani ; Betreuer: Alfred Nordheim." Tübingen : Universitätsbibliothek Tübingen, 2018. http://d-nb.info/1173699864/34.

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Mahle, Deirdre A. "'Omic' Evaluation of the Region Specific Changes Induced by Non-Cholinergic Diisopropylfluorophosphate (DFP) Exposure in Fischer 344 Rat Brain." Wright State University / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=wright1347546283.

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30

Wang, Dongxue [Verfasser], Bernhard [Akademischer Betreuer] Küster, Bernhard [Gutachter] Küster, and Julien [Gutachter] Gagneur. "Comprehensive characterization of the human proteome by multi-omic analyses / Dongxue Wang ; Gutachter: Bernhard Küster, Julien Gagneur ; Betreuer: Bernhard Küster." München : Universitätsbibliothek der TU München, 2018. http://d-nb.info/1172415145/34.

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31

Hanf, Zachery R. "A Comprehensive Multi-Omic Approach Reveals a Simple Venom in a Diet Generalist, the Northern Short-Tailed Shrew, Blarina brevicauda." The Ohio State University, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=osu1555176292214023.

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Nobori, Tatsuya [Verfasser], Paul [Gutachter] Schulze-Lefert, Stanislav [Gutachter] Kopriva, and Corne [Gutachter] Pieterse. "In planta multi-omic profiling of pathogenic and commensal bacteria / Tatsuya Nobori ; Gutachter: Paul Schulze-Lefert, Stanislav Kopriva, Corne Pieterse." Köln : Universitäts- und Stadtbibliothek Köln, 2019. http://d-nb.info/1185067051/34.

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CAPORALE, NICOLO'. "A UNIFYING FRAMEWORK TO STUDY THE GENETIC AND ENVIRONMENTAL FACTORS SHAPING HUMAN BRAIN DEVELOPMENT." Doctoral thesis, Università degli Studi di Milano, 2020. http://hdl.handle.net/2434/697871.

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The development of human brain is a fascinating and complex process that still needs to be uncovered at the molecular resolution. Even though animal studies have revealed a lot of its unfolding, the fine regulation of cellular differentiation trajectories that characterizes humans has become only recently open to experimental tractability, thanks to the development of organoids, human cellular models that are able to recapitulate the spatiotemporal architecture of the brain in a 3D fashion. Here we first benchmarked human brain organoids at the level of transcriptomic and structural architectu

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Curti, Nico. "Implementazione e benchmarking dell'algoritmo QDANet PRO per l'analisi di big data genomici." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2016. http://amslaurea.unibo.it/12018/.

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Dato il recente avvento delle tecnologie NGS, in grado di sequenziare interi genomi umani in tempi e costi ridotti, la capacità di estrarre informazioni dai dati ha un ruolo fondamentale per lo sviluppo della ricerca. Attualmente i problemi computazionali connessi a tali analisi rientrano nel topic dei Big Data, con databases contenenti svariati tipi di dati sperimentali di dimensione sempre più ampia. Questo lavoro di tesi si occupa dell'implementazione e del benchmarking dell'algoritmo QDANet PRO, sviluppato dal gruppo di Biofisica dell'Università di Bologna: il metodo consente l'elaborazion

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VITRIOLO, ALESSANDRO. "MULTI-OMIC DECONVOLUTION OF THE REGULATORY NETWORKS UNDERLYING NEURODEVELOPMENTAL AND AUTISM SPECTRUM DISORDERS: A MULTIDIMENTIONAL ANALYSIS FOR A NEW DISEASE MODELLING PARADIGM." Doctoral thesis, Università degli Studi di Milano, 2019. http://hdl.handle.net/2434/609586.

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Recent literature has highlighted that mutations causing neurodevelopmental syndromes are particularly enriched in genes related to chromatin regulation and synaptic functions. While the latter could be easily predicted, the former shed seeds to the flourishing of epigenomic studies focused on this type of disorders. Intriguingly, most of such disorders couple different shades of intellectual disabilities with peculiar cranio-facial features and systemic defects which are shared, opposite or unique across them. I have set up a dynamic framework of analysis, that encompasses the comparison of m

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Arsenteva, Polina. "Statistical modeling and analysis of radio-induced adverse effects based on in vitro and in vivo data." Electronic Thesis or Diss., Bourgogne Franche-Comté, 2023. http://www.theses.fr/2023UBFCK074.

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Dans ce travail nous abordons le problème des effets indésirables induits par la radiothérapie sur les tissus sains. L'objectif est de proposer un cadre mathématique pour comparer les effets de différentes modalités d'irradiation, afin de pouvoir éventuellement choisir les traitements qui produisent le moins d'effets indésirables pour l’utilisation potentielle en clinique. Les effets secondaires sont étudiés dans le cadre de deux types de données : en termes de réponse omique in vitro des cellules endothéliales humaines, et en termes d'effets indésirables observés sur des souris dans le cadre

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Portela, Rui Miguel Correia. "Hybrid systems biology: application to Escherichia coli." Master's thesis, Faculdade de Ciências e Tecnologia, 2011. http://hdl.handle.net/10362/6143.

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Dissertation presented to obtain a Master degree in Biotechnology<br>In complex biological systems, it is unlikely that all relevant cellular functions can be fully described either by a mechanistic (parametric) or by a statistic (nonparametric) modelling approach. Quite often, hybrid semiparametric models are the most appropriate to handle such problems. Hybrid semiparametric systems make simultaneous use of the parametric and nonparametric systems analysis paradigms to solve complex problems. The main advantage of the semiparametric over the parametric or nonparametric frameworks lies in tha

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Liang, Ziting. "Incremental democratization with Chinese characteristics." Thesis, University of Birmingham, 2011. http://etheses.bham.ac.uk//id/eprint/3247/.

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This thesis is centrally concerned with the ‘democratic debate’ and assessing the prospects for democratic transition in contemporary China. The first part of the thesis (including Chapters 1 and 2) reviews the (primarily) Western academic literature on democracy and democratisation. It is argued that while this literature is useful-up to a point-in understanding how the debate of democratisation is unfolding in China, and the processes that are generating political reforms and other changes that are conducive to democracy, it has wholly neglected the specificity of the Chinese case. The third

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Benoist, Louis. "Etude du système immunitaire chez la seiche Sepia officinalis : un potentiel pour l'aquaculture Omic Analysis of the Sepia officinalis White Body: New Insights into Multifunctionality and Haematopoiesis Regulation In-Depth In Silico Search for Cuttlefish (Sepia officinalis) Antimicrobial Peptides Following Bacterial Challenge of Haemocytes." Thesis, Normandie, 2020. http://www.theses.fr/2020NORMC226.

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Les Céphalopodes comme la seiche Sepia officinalis, malgré une durée de vie courte, sont retrouvés dans les océans depuis des millions d’années. Chez ces animaux atypiques, peu de pathologies ont été observées révélant la présence d’un système immunitaire efficace mais peu étudié qui repose sur des processus innés. L’étude du système immunitaire de la seiche a été menée au niveau du corps blanc, organe hématopoïétique ; des cellules circulantes, les hémocytes et au niveau de la peau, première barrière avec le milieu extérieur. Au niveau du corps blanc, l’étude transcriptomique et protéomique a

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RIZZUTI, LUDOVICO. "PATIENT-SPECIFIC MODELLING OF SYNDROMIC AUTISM: UNCOVERING THE ROLE OF ADNP IN CHROMATIN DYSREGULATION." Doctoral thesis, Università degli Studi di Milano, 2022. http://hdl.handle.net/2434/907414.

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ADNP encodes Activity-Dependent Neuroprotective Protein, whose de novo heterozygous mutations cause Helsmoortel-Van der Aa Syndrome (HVDAS), a rare developmental syndrome affecting brain formation and neuronal functions, involving autism spectrum disorder and intellectual disability. Although ADNP is one of the single-gene most frequently mutated in ASD, its precise role in the syndrome onset has yet to be clarified. ADNP is the DNA-binding component of the newly identified chromatin remodeler complex ChAHP in mESC. It recognizes euchromatin regions to establish less accessible local chromatin

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Shah, Ismail. "Modeling and Forecasting Electricity Market Variables." Doctoral thesis, Università degli studi di Padova, 2016. http://hdl.handle.net/11577/3427110.

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In deregulated electricity markets, accurate modeling and forecasting of different variables, e.g. demand, prices, production etc. have obtained increasing importance in recent years. As in most electricity markets, the daily demand and prices are determined the day before the physical delivery by means of (semi-) hourly concurrent auctions, accurate forecasts are necessary for the efficient management of power systems. However, it is well known that electricity (demand/price) data exhibit some specific features, among which, daily, weekly and annual periodic patterns as well as non-constant m

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Crespo, Marion. "Analyse multi-omique des acylations de lysines d'histones pendant la gamétogénèse." Thesis, Université Grenoble Alpes (ComUE), 2019. http://www.theses.fr/2019GREAV066.

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L’aspect novateur de ce projet réside dans l’étude des acylations au niveau de la lysine K27 de l’histone H3, classiquement étudiée sous forme méthylée ou acétylée. Nous avons réalisé ce travail sur des cellules germinales méiotiques et post-méiotiques de souris. La spermiogénèse, qui implique un programme d’expression spécifique ainsi qu’une régulation fine de la transcription, est un processus particulièrement adapté à la compréhension du rôle des nouvelles modifications d’histones. Ces travaux regroupent l’utilisation de quatre approches omiques différentes, à savoir la protéomique, la méta

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LOVINO, MARTA. "Algorithms for complex systems in the life sciences." Doctoral thesis, Politecnico di Torino, 2021. http://hdl.handle.net/11583/2910082.

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Sousa, Samuel Anderson Alves de 1983. "Novas metodologias para a análise de dados em ciências ômicas e para o controle de qualidade de amostras de biodiesel-diesel." [s.n.], 2013. http://repositorio.unicamp.br/jspui/handle/REPOSIP/248548.

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Orientadores: Márcia Miguel Castro Ferreira, Alvicler Magalhães<br>Tese (doutorado) - Universidade Estadual de Campinas, Instituto de Química<br>Made available in DSpace on 2018-08-25T12:46:59Z (GMT). No. of bitstreams: 1 Sousa_SamuelAndersonAlvesde_D.pdf: 6563141 bytes, checksum: df96f3f360351f7d74d92a5834369ecf (MD5) Previous issue date: 2013<br>Resumo: Neste trabalho são apresentadas duas novas metodologias multivariadas. Na primeira, é desenvolvida uma ferramenta denominada bucketing otimizado para a correção dos desalinhamentos dos espectros de RMN 1H. A análise de componentes principai

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Carriot, Nathan. "Caractérisation de la production métabolique de biofilms marins. : Vers une application à l'étude de biofilms complexes in situ." Electronic Thesis or Diss., Toulon, 2022. http://www.theses.fr/2022TOUL0001.

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Le phénomène de biofouling est un processus naturel qui impacte toutes les surfaces immergées en milieu marin engendrant des problèmes économiques et écologiques majeurs à l’échelle planétaire. Il est notamment induit par la formation de biofilms marins correspondant à la colonisation des surfaces immergées par des bactéries s’organisant en communautés en s’entourant d’une matrice de substances polymériques extracellulaires (EPS). L’objectif de ce travail est l’utilisation et le développement de méthodologies permettant l’étude et la compréhension de l’étape précurseur de ce phénomène. La corr

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Chocu, Sophie. "Découverte de nouvelles protéines impliquées dans la spermatogenèse chez le rat." Thesis, Rennes 1, 2014. http://www.theses.fr/2014REN1S064/document.

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La spermatogenèse chez les mammifères est une fonction biologique complexe incluant des processus de prolifération cellulaire, de méiose et de différenciation uniques visant à la production des gamètes mâles au sein du testicule. Si l’épithélium séminifère est bien décrit sur le plan de son organisation et de la morphologie des cellules qui le composent, les processus par lesquels les cellules germinales diploïdes indifférenciées entrent en méiose pour donner ensuite des cellules haploïdes subissant par la suite de nombreuses transformations morphologiques, ne sont pas totalement décryptés. Il

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Raad, Sabine. "Développement de nouveaux tests fonctionnels d'aide à l'interpretation des variants de signification biologique inconnue dans le cadre de prédispositions génétiques au cancer." Thesis, Normandie, 2018. http://www.theses.fr/2018NORMR079.

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L’identification des mutations constitutionnelles à l’origine d’une prédisposition génétique au cancer est essentielle à la prise en charge médicale des patients et de leurs familles. Depuis l’implémentation des technologies de séquençage à haut-débit dans les laboratoires diagnostiques, le principal défi n’est plus la détection des variations génétiques mais leur interprétation et leur classification. La question de l’interprétation de la variation est particulièrement cruciale lorsqu’elle conditionne la stratégie thérapeutique. Ainsi, il est essentiel de disposer de tests simples adaptables

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Wack, Maxime. "Dimension longitudinale du suivi omique dans les entrepôts de données cliniques : application aux cancers suivis par biopsie liquide." Electronic Thesis or Diss., Université Paris Cité, 2024. http://www.theses.fr/2024UNIP5258.

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Une nouvelle technique en génomique virale permet la capture et le séquençage d'HPV (Human Papilloma Virus) chez les patients porteurs. L'intégration de ces données aux informations médicales des Entrepôts de Données Cliniques (EDCs) ouvre de nouvelles perspectives en recherche translationnelle sur les cancers viro-induits. Cependant, les données génomiques nécessaires ne sont pas disponibles dans les EDCs, mais dans des outils dédiés limitant leur utilisation pour ces études. Nous proposons viroCapt, un pipeline bioinformatique automatisant l'analyse des données de capture HPV, permettant la

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Czerwińska, Urszula. "Unsupervised deconvolution of bulk omics profiles : methodology and application to characterize the immune landscape in tumors Determining the optimal number of independent components for reproducible transcriptomic data analysis Application of independent component analysis to tumor transcriptomes reveals specific and reproducible immune-related signals A multiscale signalling network map of innate immune response in cancer reveals signatures of cell heterogeneity and functional polarization." Thesis, Sorbonne Paris Cité, 2018. http://www.theses.fr/2018USPCB075.

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Les tumeurs sont entourées d'un microenvironnement complexe comprenant des cellules tumorales, des fibroblastes et une diversité de cellules immunitaires. Avec le développement actuel des immunothérapies, la compréhension de la composition du microenvironnement tumoral est d'une importance critique pour effectuer un pronostic sur la progression tumorale et sa réponse au traitement. Cependant, nous manquons d'approches quantitatives fiables et validées pour caractériser le microenvironnement tumoral, facilitant ainsi le choix de la meilleure thérapie. Une partie de ce défi consiste à quantifier

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Heng-HuiLiu and 劉恒惠. "Intelligent Biomedical Information Summarization for Omic Study." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/14042056071648837233.

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