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Carey, Christine. "Omega Point." ScholarWorks@UNO, 2013. http://scholarworks.uno.edu/honors_theses/32.
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Burlamaqui, IdÃlia Maria Brasil. "Hyperlipidic, normolipidic and hypolipidic diets with low omega-6:omega-3 ratio and high omega-9:omega-6 ratio on colorectal carcinogenesis in rats." Universidade Federal do CearÃ, 2014. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=11938.
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CoordenaÃÃo de AperfeiÃoamento de NÃvel SuperiorCÃncer colorretal tem alta incidÃncia, sendo influenciado por fatores genÃticos e ambientais. Estudos sugerem que Ãcidos graxos Ãmegas 3, 6 e 9 estÃo envolvidos na sua gÃnese e prevenÃÃo. Objetivo foi verificar efeitos de dietas hiperlipÃdica, normolipÃdica e hipolipÃdica, com baixa relaÃÃo -6:-3 e alta -9:-6 na carcinogÃnese colorretal induzida por azoximetano (AOM). Foram usados 60 ratos Wistar, 3 semanas de idade, pesando 40 a 50g e distribuÃdos em 5 grupos de 12 animais: GI- Dieta PadrÃo sem AOM; GII- Dieta PadrÃo e AOM; GIII- Dieta HiperlipÃdica e AOM; GIV- Dieta NormolipÃdica e AOM; GV- Dieta HipolipÃdica e AOM. Avaliados peso e ingesta 4 vezes por semana atà a 36Â. Os colos foram analisados quanto à presenÃa de tumores, focos de criptas aberrantes, nÃmero de criptas por foco, incidÃncia, invasÃo, atipias e multiplicidade dos carcinomas. Determinaram-se colesterol total e fraÃÃes, triglicerÃdeos, glicemia, ALT e AST, glutationa, TBARS, interleucinas no plasma. Ãndice apoptÃtico e mitÃtico, NFkB, COX-2 e K-Ras foram medidos em tecido tumora. GI e GII apresentaram aumento da massa corporal em relaÃÃo aos GIII, GIV e GV. Ingestas de GI e GII foram maiores que em GIII, GIV e GV. Houve reduÃÃo do nÃmero de criptas aberrantes e do total de focos com menos e mais de 5 criptas em GIV e GV comparados com GII. Houve diminuiÃÃo na incidÃncia dos tumores em GV. O Ãndice de carcinogÃnese foi superior no GII em relaÃÃo ao GV. Glutationa foi maior e TBARS menor em GV. IL-10 no GIII foi maior que em GI. IFNγ elevou-se em GII em relaÃÃo aos GIII e GV. TNF-α aumentou em GIV e GV em relaÃÃo ao GI. Apoptose aumentou nos grupos V, IV, III, em relaÃÃo aos GII e GI. Ãndice mitÃtico foi menor em GV em relaÃÃo aos GII, GIII e GIV. Conclui-se que dietas com baixa razÃo -6:-3 e alta -9:-6 reduzem a ingesta, massa corporal e peroxidaÃÃo lipÃdica; elevam a capacidade antioxidante e protegem contra a carcinogÃnese cÃlica.
Colorectal cancer has a high incidence and is known to be influenced by dietary factors. The fatty acids -3, -6 and -9 are believed to be involved in its genesis and prevention. The objective was to evaluate the effect of hyperlipidic, normolipidic and hypolipidic diets with low -6:-3 ratio and high -9:-6 ratio on azoxymethane (AOM) induced colorectal carcinogenesis in rats. Sixty 3-week-old male Wistar rats weighing 40-50g were assigned to 5 groups of 12 each: GI=Standard diet without AOM; GII=Standard diet and AOM; GIII=Hyperlipidic diet and AOM; GIV=Normolipidic diet and AOM; GV=Hypolipidic diet and AOM. Weight and ingestion were registered 4 times/week until the 36th week. Colons were analyzed for tumors, aberrant crypt foci, number of crypts per focus, incidence, differentiation, invasion and carcinoma multiplicity. The levels of total and fractionated cholesterol, triglycerides, glycemia, ALT, AST, glutathione, TBARS, interleukins were determined in plasma. Apoptosis, mitosis, NFkB, COX-2 and K-Ras were measured in tumor tissue. Body mass was greater in GI and GII than in GIII, GIV and GV. Ingestion was greater in GI and GII than in GIII, GIV and GV. The number of aberrant crypts and the total number of foci with <5 and >5 crypts decreased in GIV and GV compared to GII. In GV, the incidence of tumors was reduced. The index of carcinogenesis was higher in GII than in GV. Glutathione was higher and TBARS was lower in GV. GIII was higher than in GI with regard to IL-10. IFNγ was higher in GII than in GIII and GV. TNF-α was higher in GIV and GV than in GI. Apoptosis increased in GV, GIV and GIII in relation to GII and GI. The mitotic index was lower in GV than in GII, GIII and GIV. In conclusion, hyperlipidic, normolipidic and hypolipidic diets with low -6:-3 ratio and high -9:-6 ratio reduce ingestion, body mass and lipid peroxidation; increase the antioxidant capacity and offer protection against colorectal carcinogenesis.
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Melo, RadamÃs Bezerra. "Anti-inflammatory and antioxidant action of oil mixes of omega 9, 6 and 3 with low ratio omega-6/omega-3 and high ratio omega-9/omega-6 after dental extraction in rats." Universidade Federal do CearÃ, 2014. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=17575.
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CoordenaÃÃo de AperfeÃoamento de Pessoal de NÃvel SuperiorOil fatty acids omega-3 and omega-9 have anti-inflammatory and antioxidant activities, while the omega-6 has pro-inflammatory action. The aim of this study was to evaluate the presence of antioxidant and anti-inflammatory effects with high nutraceutical ratio of omega-9: omega-6, antioxidant properties, and low ratio omega-6: omega-3, anti-inflammatory properties three days after tooth extraction in rats. Thirty-two young Wistar rats with 270-310g were randomly divided into four groups of 8 animals: Group Sham, Saline Group, Isolipid Group, and Mix Test Group. The animals received 0.9% NaCl, Sham Group and Salina Group, or Isolipid Mix (alpha-linolenic acid - ALA) mixture containing omega-6: omega-3 oils (ratio 8:01) and omega-9: omega-6 (ratio 0.4:1), Isolipid group, or Mix Test (alpha-linolenic acid - ALA, docosahexaenoic acid - DHA, eicosapentaenoic acid - EPA) omega-6: omega-3 (ratio 1.4: 1) and omega-9: omega -6 (3.4:1 ratio), Mix Text Group by gavage 1.2g solutions for kg/day for four days before and three days after the extraction of the left mandibular first molar. Evaluation of edema generated by the surgical procedure and collected the perialveolar the site of tooth extraction and dental alveolar mucosa itself for laboratory testing were performed: myeloperoxidase, osteoclast count, concentrations of TNF-α and IL-1β, glutathione (GSH) and thiobarbituric acid reactive substances (TBARS). The Mix Test induced a significant decrease on post-operative edema, myeloperoxidase , osteoclasts count , GSH in blood and tissue, on tissue and plasma TBARS and on the TNF-αconcentration, but did not show significant difference on the IL-1β concentration at the third post-operative day. The gavage with the Mix Test showed anti-inflammatory and antioxidant actions after molar tooth extraction in rats.
Os Ãcidos graxos insaturados Ãmega-3 e Ãmega-9 possuem aÃÃo anti-inflamatÃria e antioxidante, enquanto o Ãmega-6 possui aÃÃo prÃ-inflamatÃria. O objetivo do presente estudo foi avaliar a aÃÃo antioxidante e anti-inflamatÃria do mix de Ãleos em concentraÃÃes nutracÃuticas com alta razÃo Ãmega-9: Ãmega-6, favorecendo aÃÃo antioxidante, e baixa razÃo Ãmega-6:Ãmega-3, favorecendo aÃÃo anti-inflamatÃria no terceiro dia pÃs exodontia em ratos. Foram utilizados trinta e dois ratos Wistar jovens com 270-310g distribuÃdos aleatoriamente em quatro grupos de 8 animais: Grupo Sham, Grupo SoluÃÃo Salina, Grupo mix isolipÃdico e Mix Teste. Os animais receberam NaCl 0,9%, Grupo Sham e Grupo SoluÃÃo Salina, ou mix isolipÃdico, (Ãcido alfa-linolÃico - ALA) mistura contendo Ãmega-6:Ãmega-3 Ãleos (relaÃÃo de 8:01) e Ãmega-9:Ãmega-6 (relaÃÃo 0,4:1), Grupo IsolipÃdico, ou Mix Teste (Ãcido alfa-linolÃnico - ALA, Ãcido docosahexaenÃico - DHA, Ãcido eicosapentaenÃico - EPA) de Ãmega-6:Ãmega-3 (relaÃÃo 1,4:1) e Ãmega-9:Ãmega -6 (3,4:1 relaÃÃo), Grupo Teste, receberam por gavagem 1,2g da soluÃÃo correspondente a cada grupo por kg/dia durante quatro dias antes e trÃs dias apÃs a exodontia do primeiro molar inferior esquerdo. Foi realizada a avaliaÃÃo do edema gerado pelo procedimento cirÃrgico e coletada a mucosa perialveolar ao sÃtio da extraÃÃo dental e o prÃprio alvÃolo dental para anÃlises laboratoriais: mieloperoxidase, contagem de osteoclastos, expressÃo do TNF-α e IL-1β, glutationa (GSH) e substÃncias reativas ao Ãcido tiobarbitÃrico (TBARS). O Mix Teste induziu uma diminuiÃÃo significante na atividade da mieloperoxidase,no edema pÃs operatÃrio, na contagem de osteoclastos, na GSH plasmÃtica e do tecido, nas concentraÃÃes plasmÃticas e do tecido de TBARS, na expressÃo do TNF-α, mas nÃo mostrou diferenÃa significante na expressÃo de IL-1β no terceiro dia pÃs-operatÃrio. A administraÃÃo por gavagem do Mix Teste demonstrou uma reduÃÃo da resposta inflamatÃria e oxidante, atuando como anti-inflamatÃrio e antioxidante, apÃs exodontia em ratos
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Kurilla, Udo. "Analyse der Endzustände op0 [omega pi0], oj [omega eta] und oj' [omega eta'] in der Proton-Antiproton-Annihilation im Fluge." [S.l.] : [s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=968945724.
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Novak, Elizabeth Marie. "Dietary omega-3 and omega-6 fatty acids and neonatal liver metabolism." Thesis, University of British Columbia, 2011. http://hdl.handle.net/2429/36743.
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It is well-known that the n-3 fatty acids are important regulators of fat and glucose metabolism in adult liver; however, to date most research on the importance of n-3 fatty acids in early development has focused on the brain, with little consideration of effects on other organs. This research addressed the importance of the essential n-3 and n-6 fatty acids for the liver during early development. A series of studies were conducted to address the impact of the amount, balance, and types of n-6 and n-3 fatty acids in the maternal diet and infant milk diet on lipids, protein abundance, gene expression, and relevant metabolites in the developing liver. Using milk-formula fed piglets, the first study demonstrated that the supply of n-6 and n-3 fatty acids impacts infant liver fatty acids, with high dietary n-6 fatty acids decreasing hepatic n-3 fatty acids in a pattern similar to n-3 fatty acid deficiency. Using the rat to address the impact of maternal fatty acid nutrition in gestation and lactation on the infant liver, the second study showed that adding n-3 fatty acids to the maternal diet lead to higher long chain n-3 fatty acids in neonatal liver, and this was associated with higher expression of enzymes of fatty acid oxidation and lower expression of enzymes of glycolysis and amino acid catabolism, with altered amino acid patterns when compared to n-3 fatty acid deficiency. In the third study, providing long chain n-3 fatty acids in the maternal diet led to marked increase in long chain n-3 fatty acids in milk and in the liver of the milk-fed rat pups, and this was associated with lower gene expression for enzymes of fatty acid synthesis and glycolysis and higher gene expression for an enzyme of ketogenesis in the neonatal liver. These studies provide new knowledge to show that the amount, types and balance of n-3 and n-6 fatty acids in the maternal and infant diet are relevant to hepatic metabolic regulation in the early postnatal period. Nutrition support of young infants should consider the needs and functions of n-3 fatty acids beyond the brain.
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Tsipolitis, George. "[Omega omega] and [rho]+[rho-] production in two photon interactions at ARGUS." Thesis, McGill University, 1990. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=74351.
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The reactions $ gamma gamma$ $ to$ 2$ pi sp+2 pi sp-2 pi sp0$ and $ gamma gamma to pi sp+ pi sp- pi sp0 pi sp0$ have been studied by using the ARGUS detector at the $e sp+e sp-$ storage ring DORIS II at DESY.In the $2 pi sp+2 pi sp-2 pi sp0$ final state the production of $ omega$-mesons is observed and in particular the reaction $ gamma gamma$ $ to$ $ omega omega$ is seen for the first time. The cross section for $ gamma gamma to omega omega$ is found to have an enhancement at $ sim$1.9GeV/c$ sp2$ of about 12 nb. The topological cross sections for the reactions $ gamma gamma$ $ to$ 2$ pi sp+2 pi sp-2 pi sp0$ and $ gamma gamma$ $ to$ $ omega pi sp+ pi sp- pi sp0$ are also measured.
The production of charged $ rho$-mesons is observed in the $ pi sp+ pi sp- pi sp0 pi sp0$ final state. The cross section for the reaction $ gamma gamma$ $ to$ $ rho sp+ rho sp-$ is measured for the first time. The cross section did not show a threshold enhancement similar to that found in the reaction $ gamma gamma$ $ to$ $ rho sp0 rho sp0$ and is about a factor of four smaller. A spin parity analysis of the $ rho sp+ rho sp-$ system shows that the cross section is dominated by the two amplitudes $J sp{P}$ = 0$ sp+$ and $J sp{P}$ = 2$ sp+$ with helicity 2.
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Galles, Deborah Pedroso. "Importância da relação dos ácidos graxos omega-6/omega-3 na alimentação." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/74/74132/tde-14052015-095032/.
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O experimento foi realizado no Biotério Experimental da USP em Pirassununga - SP. Na primeira fase foram utilizados 42 coelhos machos em crescimento da raça Nova Zelândia mantidos individualmente durante todo o experimento. O ensaio biológico totalizou 150 dias. Na Fase 1 os animais receberam dietas com indução de hipercolesterolemia (0,5% de colesterol), com desequilíbrio na proporção de Omega-6/Omega-3 (n-6:n-3) de 15:1 e vice versa e balanço na proporção de n-6:n-3 de 4:1 (controle), totalizando 6 ensaios, os quais foram divididos aleatoriamente em 7 grupos de 6 coelhos cada. Óleos de girassol e de peixe foram utilizados como fontes de ácidos graxos poli-insaturados n-6 e n-3, respectivamente. Na Fase 2, os animais remanescentes continuaram recebendo as mesmas dietas, exceto no grupo B (hipercolesterolemia) que passou a receber o tratamento controle para verificar o efeito. No final da Fase 1, três animais de cada grupo foram eutanasiados com retirada da artéria aorta para determinação de placas lipídicas, histopatológica, colesterol total e imunohistoquímica para verificação da expressão da enzima LDL-receptor e determinação histopatológica do tecido hepático. Em soro foram realizadas determinações de perfil de ácidos graxos, colesterol total, LDL e HDL-colesterol e triacilgliceróis. Células endoteliais aórticas de coelhos foram isoladas para a realização do teste dose resposta com óleo de peixe para identificar a melhor relação do consumo destes ácidos graxos comparando com o experimento in vivo. O objetivo deste trabalho foi monitorar os efeitos do fornecimento de cada dieta sobre o teor de colesterol total, LDLcolesterol, HDL-colesterol e triacilgliceróis em sangue de coelhos. No geral, o perfil de ácidos graxos no soro correspondeu diretamente com a dieta consumida. Os principais efeitos dos ácidos graxos poli-insaturados Omega 3 foi a redução dos lipídios séricos quando os coelhos remanescentes da dieta hipercolesterolêmica (0,5% de colesterol e n-6:n-3 de 2:1) passaram a receber o equilíbrio da relação de ácidos graxos 4:1 de n-6:n-3. O teor de colesterol total no soro, artérias e o crescimento dos ateromas foram influenciados pelo elevado consumo de ácidos graxos n-6 e n-3 associados à adição de colesterol nas dietas. Por outro lado verificamos que o excesso de Omega 3 associado ou não ao colesterol contribuiu para o agravamento das placas ateroscleróticas inclusive deposição de cálcio nas mesmas e paredes endoteliais. Provavelmente, o excesso de n-3 tenha ocasionado efeito contrário às suas funções anti-inflamatória, antiagregatória e anti-trombótica. Dietas hipercolesterolêmicas provocaram esteatose hepática e o elevado consumo de Omega-6 em detrimento do baixo consumo de Omega -3 induziram hepatite crônica. Já o consumo elevado de Omega-3, sem colesterol, regrediu a esteatose hepática nos animais. O consumo equilibrado de n-6:n-3 reduziu a expressão da enzima LDL-receptor no grupo que anteriormente recebeu dieta hipercolesterolêmica. Ressaltando-se a importância do consumo equilibrado destes ácidos graxos já que esta enzima é controlada pelo colesterol livre circulante. No teste dose-resposta em células endoteliais da aorta de coelhos foi evidenciado que a melhor proporção de n-6:n-3 seria de 9 vezes mais do que a concentração de Omega 3 recomendada de 5:1.The experiment was conducted at the Experimental Biotery by USP in Pirassununga - SP. In the first phase were used 42 male rabbits growing New Zealand breed individually maintained throughout the experiment. The biological assay amounted to 150 days. In phase 1, the animals received diets induced hypercholesterolemia (0.5% cholesterol) with imbalance in the ratio of Omega-6 / Omega-3 (n-6 / n-3) 15:1 and vice versa, and balance the ratio of n-6 / n-3 of 4:1 (control), totaling six tests, which were randomly divided into 7 groups of six rabbits each. Sunflower and fish oils were used as sources of fatty acids polyunsaturated n-6 and n-3, respectively. In Phase 2, the remaining animals continued to receive the same diets except in group B (hypercholesterolemia) who went on to receive the control treatment to check the effect. At the end of Phase 1, three animals from each group were sacrificed with the aorta artery removed for determination of lipid plaques, histopathology, immunohistochemistry and total cholesterol to verify the expression of LDL-receptor enzyme and determination of histopathological liver tissue. In serum profile were made determinations of fatty acids, total cholesterol, LDL and HDL cholesterol and triglycerides. Aortic endothelial cells of rabbits were isolated to perform the dose response test with fish oil to identify the best value for the consumption of these fatty acids compared to the in vivo experiment. The objective of this work was to monitor the effects of provision for each diet on total cholesterol, LDL-cholesterol, HDLcholesterol and triglycerides in the blood of rabbits. In general, the profile of fatty acids in serum corresponded directly with the diet consumed. The main effects of polyunsaturated Omega 3 fatty acids was the reduction of serum lipids when the remaining rabbits with hypercholesterolemic diet (0.5% cholesterol and n-6: n-3 2:1) have received the balance of the relationship fatty acid 4:1 n-6: n-3. The total cholesterol content in serum, the growth of arteries and atheroma were influenced by a high intake of n-6 fatty acids and n-3 associated with the addition of cholesterol in diets. On the other hand we verified that the excess of Omega 3 with or without cholesterol contributed to the aggravation of the atherosclerotic plaques including deposition of calcium in them and endothelial walls. Probably the excess of n-3 has caused the opposite effect to their anti-inflammatory, anti-thrombotic and anti-aggregatory functions. Hypercholesterolemic diets caused hepatic steatosis and high intake of Omega-6 to the detriment of low consumption of Omega -3 induced chronic hepatitis. High consumption of Omega-3, no cholesterol, decreased hepatic steatosis in animals. Highlighting the importance of the balanced intake of this fatty acids, since this enzyme is controlled by circulating free cholesterol. In dose-response test in endothelial cells of the rabbits aorta was evident that the best ratio of n-6: n-3, nine times more than the recommended concentration of Omega 3 to 5:1.
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Liu, Kecheng. "Stationary subsets of aleph sub omega super less than omega sub n /." The Ohio State University, 1992. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487778663288101.
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Aranda, López Andrés. "Omega-categorical simple theories." Thesis, University of Leeds, 2013. http://etheses.whiterose.ac.uk/7838/.
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This thesis touches on many different aspects of homogeneous relational structures. We start with an introductory chapter in which we present all the background from model theory and homogeneity necessary to understand the results in the main chapters. The second chapter is a list of examples. We present examples of binary and ternary homogeneous relational stuctures, and prove the simplicity or non-simplicity of their theory. Many of these examples are well-known structures (the ordered rational numbers, random graphs and hypergraphs, the homogeneous Kn-free graphs), while others were constructed during the first stages of research. In the same chapter, we present some combinatorial results, including a proof of the TP2 in the Fraïssé limit of semifree amalgamation classes in the language of n-graphs, such that all the minimal forbidden configurations of the class of size at least 3 are all triangles. The third chapter contains the main results of this thesis. We prove that supersimple finitely homogeneous binary relational structures cannot have infinite monomial SU-rank, show that primitive binary supersimple homogeneous structures of rank 1 are “random” in the sense that all their minimal forbidden configurations are of size at most 2, and partially classify the supersimple 3-graphs under the assumption of stable forking in the theories of finitely homogeneous structures with supersimple theory. The fourth chapter is a proof of the directed-graph version of a well-known result by Erdős, Kleitman and Rothschild. Erdős et al. prove that almost all finite labelled trianglefree simple graphs are bipartite, and we prove that almost all finite labelled directed graphs in which any three distinct vertices span at least one directed arc consist of two disjoint tournaments, possibly with some directed arcs from one to the other.
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Nilsson, Hanna. "En litteraturstudie om effekten av omega-3 och omega-6 på torra ögon." Thesis, Linnéuniversitetet, Institutionen för naturvetenskap, NV, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-12969.
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Syftet med arbetet var att sammanställa vad som tidigare har skrivits om de essentiella fettsyrorna och huruvida de har effekt på ögats främre delar, framför allt på det torra ögat. Denna litteraturstudie har genomförts med hjälp av artiklar som hittats på PubMed och Google Scholar, med hjälp av sökord såsom ’nutrition, dry eye, omega-3 och fatty acids’,men även med hjälp av andra artiklars referenslistor. Artiklarna har sedan sammanställts tilldetta arbete. Efter sammanställning av artiklarna är det möjligt att skönja en mildrande effekt av omega-6 fettsyror på symtom på torra ögon och även en ökning av tårproduktionen. Även omega-3 fettsyror tycks ha dessa egenskaper och kan därför hjälpa det torra ögat. Dock tycks en högre omega-6:omega-3 – kvot leda till en ökad risk för torra ögon, vilket faktiskt till viss del motsäger resultatet att omega-6 fettsyror fungerar förbättrande för torra ögon. För att minska omega-6:omega-3 – kvoten bör mer omega-3 fettsyror intas via födan, gärna också de längre kedjorna EPA och DHA, då endast en liten del av den kortare omega-3kedjan ALA kan omvandlas till EPA och DHA som också finns i viss fisk. Utifrån detta arbete kan slutsatsen att ett tillskott av endast omega-3 fettsyror kan vara till fördel för det torra ögat dras, men kan också vara bra för att omega-6:omega-3 – kvoten ska hållas nere, vilket tycks vara till fördel för att risken för torra ögon ska minskas.
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Wang, Lei. "MODULATION OF ENDOTHELIAL CELL ACTIVATION BY OMEGA-6 AND OMEGA-3 FATTY ACIDS." UKnowledge, 2007. http://uknowledge.uky.edu/gradschool_diss/573.
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Endothelial activation is considered to be an early and critical event in the pathology of atherogenesis which can be modified by environmental factors such as diet, pollutants, and lifestyle habits. Dietary andamp;ugrave;-6 and andamp;ugrave;-3 fatty acids have been reported to either amplify or diminish inflammatory responses related to atherosclerosis development. However, the interactions of andamp;ugrave;-6 and andamp;ugrave;-3 fatty acids with inflammatory cytokines or organic pollutants on endothelial cell activation are not well understood. The studies presented in this dissertation tested the hypothesis that andamp;ugrave;-6 and andamp;ugrave;-3 fatty acids alone, or in varying ratios can differently modulate pro-atherogenic mediators and inflammatory responses that are initiated by tumor necrosis factor- andamp;aacute; (TNF-andamp;aacute;) or polychlorinated biphenyls (PCBs) in endothelial cells. Exposure to TNF-andamp;aacute; induced oxidative stress, p38 MAPK, NF-andamp;ecirc;B, COX-2 and PGE2, which was amplified by pre-enrichment with linoleic acid but blocked or reduced by andamp;aacute;-linolenic acid. Furthermore, TNF-andamp;aacute;-induced caveolin-1 up-regulation and the co-localization of TNF receptor-1 with caveolin-1 was markedly increased in the presence of linoleic acid and diminished by andamp;aacute;-linolenic acid. Silencing of the caveolin-1 gene completely blocked TNF-andamp;aacute;-induced production of COX-2 and PGE2 and significantly reduced the amplified response of linoleic acid plus TNF-andamp;aacute;. These data suggest that omega-6 and omega-3 fatty acids can differentially modulate TNF-andamp;aacute;-induced inflammatory stimuli and that caveolae and its fatty acid composition play a regulatory role in these observed metabolic events. Besides cytokines, lipophilic environmental contaminants such as PCBs can also trigger inflammatory events in endothelial cells. Our data suggest that increasing the relative amount of andamp;aacute;-linolenic acid to linoleic acid can markedly decrease oxidative stress and NF-andamp;ecirc;B-responsive genes. The inhibitor study revealed that the modulation effect of andamp;ugrave;-6 and andamp;ugrave;-3 fatty acids on PCB toxicity was mainly through the oxidative stress sensitive transcription factor, NF-andamp;ecirc;B. In conclusion, our studies demonstrate that different dietary fats can selectively modulate vascular cytotoxicity caused by TNF-andamp;aacute; as well as by persistent organic pollutants such as PCBs. We also demonstrated the important relevance of substituting dietary andamp;ugrave;-3 fatty acids such as andamp;aacute;-linolenic acid for andamp;ugrave;-6 fatty acid such as linoleic acid in reducing cardiovascular diseases.
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Barnard, Donald Edwin. "A critical edition of Derek Walcott's Omeros." Thesis, University of Warwick, 2012. http://wrap.warwick.ac.uk/46005/.
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The thesis is a Critical Edition of Derek Walcott’s Omeros, consisting of a Critical Introduction and Annotations. The Critical Introduction analyses: - Narrative - Settings - Metaphor and Paronomasia - Symbolism - Historiography - Intertexts - Dualism - Autobiography - Dialects - Prosody. The Annotations comment on more than 1000 references that may be obscure and on specifics of narrative, language and prosody. This study presents new conclusions about some aspects of Omeros: - It challenges the prevailing view that the work is written substantially in a variation of terza rima and shows that regular quatrains predominate. - It demonstrates ways in which the metrics follow the sense of the narrative and takes a more balanced position on the use of Caribbean as opposed to classical metrics than that put forward previously. - It identifies a paragraphic structure to the verse. - It proposes a new prosodic structure for the significant Chapter XXX/iii. - It extends Walcott’s recognised use of numerology into word counting the names of characters. - It develops the idea of Walcott’s dualism and his use of pairing and contradiction as a dialectical method. - It defines his wide use of paronomasia and shows that many of the puns have a metaphorical aspect beyond mere word-play. - It analyses some of Walcott’s symbolism. - It identifies intertextual links to his earlier works and to some thirty other writers, and suggests homage to Hemingway and possibly Heaney. - It provides the first complete analysis of Walcott’s rhyme types in Omeros. In its analysis of Omeros and in the Annotations it has included commentary from across the critical literature, to provide some sense of other views on Walcott’s writing, and has included as many as possible of Walcott’s own comments on Omeros and on the writer’s task, as a background to understanding the poem.
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Nilsson, Anna-Stina, and Sanna Engerdahl. "Omega-3-tillskott eller fisk? : En kartläggning av studenters användande av omega-3-tillskott." Thesis, Uppsala universitet, Institutionen för kostvetenskap, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-167509.
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Söderberg, Karin. "Skyddar omega-3 mot demens?" Thesis, Umeå universitet, Farmakologi, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-119800.
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Det finns ett stort intresse för omega-3 idag på grund av dess många hälsogivande egenskaper. Brist på vissa typer av fett i kosten kan vara en viktig faktor för kognitiv nedsättning, demens och Alzheimers sjukdom. Dokosahexaensyra (DHA) är den dominerande omega-3-fettsyran i hjärnan. Det finns många faktorer som förklarar varför fettsyraintaget kan påverka kognitiva funktioner och risken att bli dement. Obduktionsstudier visar att patienter med Alzheimer har mindre mängd DHA i hjärnan än kognitivt intakta individer. Dessutom är serumkoncentrationerna av DHA reducerade i relation till sjukdomens svårighetsgrad. Vad som är orsak och verkan i denna process är dock inte klart. Syftet med denna litteraturstudie är att undersöka i vilken utsträckning omega-3 kan förebygga demens hos friska medelålders eller äldre (> 50 år) personer. Av de sex studier som inkluderades var två randomiserade kliniska prövningar (RCT), tre longitudinella och en tvärsnittsstudie. Två av mina utvalda studier stödjer hypotesen att omega-3 skyddar mot demens hos friska äldre, två av studierna hittar inga bevis för att omega-3 skyddar mot demens. De två randomiserade kontrollerade försök som jag hittat undersöker inverkan av omega-3 på den kognitiva förmågan och det ena försöket hittar ingen generell effekt av omega-3 på den kognitiva förmågan och det andra försöket kommer fram till att omega-3 utövar positiva effekter på den kognitiva förmågan hos friska äldre. Inga näringsrekommendationer är möjliga att ge med hjälp av denna studie.
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Lino, Gutiérrez Ana, López Edgard Arce, Mejía Hermann Ojeda, and Delgado Joseph Zevallos. "Planeamiento estratégico de Omega Tractor's." Master's thesis, Pontificia Universidad Católica del Perú, 2014. http://tesis.pucp.edu.pe/repositorio/handle/123456789/12835.
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x, 103 h. : il. ; 30 cmEl planeamiento estratégico de Omega Tractor´s desarrollado en el presente documento se realizó identificando las estrategias que la compañía debe implementar para generar un posicionamiento estratégico que le permita aprovechar las condiciones del mercado en su sector y desarrollar sus potencialidades, todo enmarcado en una visión, misión, valores y código de ética. Este planeamiento sigue la metodología del modelo secuencial del proceso estratégico. Omega Tractor’s es un compañía dedicada al rubro de comercialización de repuestos, prestación de servicios de reparación y alquiler de maquinaria pesada, con operaciones en la región sur del Perú, este sector en los 5 años previos al año 2014 se mostró muy dinámico por la gran presencia de operaciones mineras e inversión en obras civiles de infraestructura vial, lo que permite a la compañía desarrollar una propuesta comercial más agresiva y superar deficiencias internas enfocada principalmente en el desarrollo de una cultura organizacional de excelencia
Strategic planning of Omega Tractor 's developed in this paper was performed by identifying the strategies that the company should implement to generate a strategic position that allows to take advantage of market conditions in the sector and develop their potential , all framed in a vision, mission, values and ethics . This planning methodology follows the sequential model of the strategic process. Omega Tractor 's is a company dedicated to the commercialization of spare parts , service repair and rental of heavy equipment with operations in the southern region of Peru , this sector in the 5 years prior to 2014 was very dynamic due the large presence of mining operations and investment in civil works road infrastructure , enabling the company to develop a more aggressive commercial proposal and overcome internal weaknesses focused primarily on the development of an organizational culture of excellence
Tesis
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Juin, Gérard. "Autour de la fonction [omega]/." Limoges, 1996. http://www.theses.fr/1996LIMO0053.
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Le premier chapitre de cette these donne une presentation de la fonction arithmetique ainsi que certaines de ses proprietes. On donne ensuite les principaux resultats connus sur la fonction n (x, k, p#0) qui compte le nombre d'entiers naturels inferieurs au reel x, ayant k facteurs premiers (comptes avec multiplicite), tous superieurs au nombre premier p#0. Le cas p#0 = 2 est distingue des autres. Le deuxieme chapitre fournit la demonstration d'un nouveau resultat sur la fonction n (x, k, p#0), uniforme en k, pour p#0 assez grand et inferieur a la quantite (log log log x/k(39p#0) #1#-# ou est un reel quelconque compris entre 0 et 1 et fixe a l'avance. Ce resultat generalise le resultat de m. Balazard de 1987: sur la repartition des valeurs de certaines fonctions arithmetiques additives. Le troisieme chapitre donne d'autres resultats sur cette meme fonction. Ces resultats uniformes en k et p#0 sont obtenus a partir de ceux de k. Alladi dans un article de 1982 intitule the distribution of (n) in the sieve of eratostenes
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Wachs, Mirko. "Die Selbstenergie des Omega-Mesons." Phd thesis, [S.l. : s.n.], 2000. http://tuprints.ulb.tu-darmstadt.de/50/1/thesis.pdf.
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Es werden Zerfallsbreiten des Omega Mesons im Vakuum und in kalter Kernmaterie im Rahmen eines aus Pionen und Rho Mesonen bestehenden hadronischen Modells untersucht. Ausgangspunkt ist eine störungstheoretische Entwicklung in Selbstenergiediagrammen. Im ersten Abschnitt der Arbeit wird die Lagrangedichte des Modells zusammengestellt. Zur Konstruktion der Wechselwirkung von Rho Meson und Pionen bzw. Photon wird das Eichkonzept benutzt. Dabei erhält das Rho Meson durch seine Pionwolke Beiträge zur Selbstenergie. Die starken Zerfälle des Omega Mesons im Vakuum ergeben sich aus der anomalen Brechung der axialen U(1)--Symmetrie. Im zweiten Teil dieser Arbeit werden Selbstenergiediagramme bis zur Zwei--Loop--Struktur ausgewertet. Bei gleichzeitiger Erklärung der Partialbreite im Omega --> Pi + Gamma Kanal führen die berechneten Beiträge zu 57% der experimentellen Partialbreite im 3 Pi--Kanal des Omega Mesons. Die weiteren berechneten semileptonischen Dalitz--Zerfallsbreiten des Omega Mesons können mit den experimentellen Daten in Übereinstimmung gebracht werden. Die Berechnung des mikroskopischen Formfaktors am Omega,Rho,Pi Vertex erlaubt Vergleiche mit experimentellen Daten und läßt auf weitere Beiträge zur Omega Selbstenergie von höheren Diagrammen schließen. Im dritten Teil der Arbeit wird das hadronische Modell des Omega Mesons auf kalte Kernmaterie angewendet. Ausgehend von den jeweiligen Medium--Modifikationen des Rho Mesons und Pions wird das Ein--Loop--Diagramm zur Omega Selbstenergie berechnet. Für ein bei einfacher Kerndichte ruhendes Omega Meson erhält man eine Breite von 60 MeV. Die Abhängigkeit der Breite vom Dreierimpuls des Omega Mesons ist mit einigen MeV gering. Außerdem ergibt sich eine relativ schnelle Sättigung der Breite mit Anwachsen der Kerndichte.
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Secchiati, Giada <1991>. "L'esterovestizione societaria e il reato di omessa dichiarazione." Master's Degree Thesis, Università Ca' Foscari Venezia, 2017. http://hdl.handle.net/10579/10876.
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Il presente lavoro tratta una tematica di notevole rilevanza, quale quella della cosiddetta “esterovestizione” di società, con l’idea di analizzarne i profili di punibilità, prima penali e poi tributari, cogliendone, altresì, le implicazioni soggettive per il contribuente.
In questo capitolo introduttivo si intende definire il fenomeno indagato, con l’intento di chiarirne il significato e le problematiche che vi si legano, basandosi sulla normativa tributaria interna, le pronunce di Amministrazione Finanziaria e giurisprudenza e gli orientamenti in dottrina.
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Khang, Nguyen Thi Kim. "Genetic factors affecting the omega-3 and omega-6 fatty acid variation in egg yolk." [S.l.] : [s.n.], 2006. http://deposit.ddb.de/cgi-bin/dokserv?idn=982352107.
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Kunihiro, Andrew G. "The relationship between dietary omega-3 and omega-6 fatty acid intake and colorectal cancer." Thesis, California State University, Long Beach, 2014. http://pqdtopen.proquest.com/#viewpdf?dispub=1527970.
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Colorectal cancer (CRC) is the fourth leading cause of cancer-related deaths in the United States and the second most expensive. Low compliance with preventive screening predisposes a large portion of the at-risk population to poorer outcomes. Therefore, identification of primary interventions for those not regularly screened for CRC is of utmost importance. Self-reported dietary ω-3 and ω-6 fatty acid intake were used to determine the cross-sectional relationship with CRC cases (n = 211). Men and women of various ethnic backgrounds (N = 15,178) from the National Health and Nutrition Examination Survey (NHANES), 1999–2010, were eligible for inclusion in this study. Dietary ω-3 intake and the ω-3:ω-6 ratio were negatively associated with CRC while dietary ω-6 intake was positively associated with CRC, for those age 20 to < 50 years, after multivariate adjustment. The Glasgow Prognostic Score was also found to be significantly associated with both dietary ω-3 and ω-6 intake for all age groups.
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Purwaha, Preeti. "Effect of Dietary Omega-3 and Omega-6 Polyunsaturated Fatty Acids on Alcoholic Liver Disease." Diss., North Dakota State University, 2012. https://hdl.handle.net/10365/26488.
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PUFAs have been shown to modulate ALD by several mechanisms, including free radical generation from hepatic lipid peroxidation. However, how they modulate lipid peroxidation and generation of bioactive metabolites in ALD is poorly understood and it is still not clear which PUFAs (?-3 or ?-6) are beneficial or detrimental in ALD. Thus, our objective was to study the effect of ?-3/?-6 PUFAs on lipid peroxidation and ethanol mediated steatosis and inflammation. Using standard liquid diet (LDC), LDC with fish oil (rich in ?-3) and safflower oil (rich in ?-6), we studied the generation of bioactive metabolites, such as eicosanoids and free radicals generated via lipid peroxidation. In addition, we determined the effect of PUFAs on several inflammatory and fibrotic factors, e.g. gene as well as protein expression, using western blot and RT-PCR, respectively. We also investigated the effect of PUFA diets on novel targets, such as hepatic membrane transporters with potential role in liver inflammation. Our results suggest that ?-3 diet prevented while ?-6 based diets promoted the development of fatty liver and inflammation. ?-3 PUFA reduced AA-peroxidation by lowering hepatic AA concentration and expression of peroxidation enzymes, COX-2 and 5-LOX, resulting in lower generation of pro-inflammatory AA-derived PGs (Series-2), HETEs and free radicals, along with increase in anti-inflammatory EPA and DHA-derived PGs (Series-3). ?-3 diet might also reduce liver inflammation by preventing activation of NF-?B and induction of TNF-?. Rats fed with ?-3 diet showed high protein expression of efflux transporters, MRP-2 and ABCA1, indicating elimination of peroxidation metabolites and triglycerides from the liver and decreased inflammation. In contrast, ?-6 diets led to increase in AA-peroxidation and generation of AA-derived pro-inflammatory metabolites. ?-6 based diets also promoted fatty liver and inflammation by activating NF-?B, inducing TNF-? and downregulation of efflux transporters, MRP-2 and ABCA1. This study not only provides new insights into the effects and possible mechanisms by which ?-3 and ?-6 PUFAs may alter hepatic steatosis and inflammation, but also put forward new targets of research, such as hepatic membrane transporters in relation to liver pathology in ALD.
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Leva, Pedro David Huillca. "Geração de semigrupos por operadores elípticos em L POT. 2 (OMEGA) e C INF. 0 (OMEGA)." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/55/55135/tde-28042014-095009/.
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Neste trabalho estudaremos a geração do semigrupos por operadores elípticos em dois espaços. Em primeiro lugar estudaremos a geração de semigrupo no espaço \'L POT.2\' (\'OMEGA\') por operadores elípticos de ordem 2m com \'OMEGA\' suficientemente regular. Mais precisamente, se \'OMEGA\' é um domínio limitado com \'PARTIAL OMEGA\' de classe \'C POT. 2m,\' L (x;D) = \'SIGMA\' / [\'alpha\'] \'< ou =\' \'a IND. alpha\' (x) \'D POT. alpha\' é um operador diferencial elíptico de ordem 2m, com \'a IND. alpha\' \'PERTENCE\' \' \'C POT.j\' (\'OMEGA\'), j = max {0, [\'alpha\'] - m}, e A : D(A) \'ESTÁ CONTIDO\' EM \'L POT. 2 (\'OMEGA\') \'SETA\' \' L POT. 2 (\'OMEGA\') é o operador linear dado por D(A) = \'H POT. 2m\' (\'OMEGA\') \'H POT. m INF. 0\' (\'OMEGA\'), (Au)(x) = L (x;D)u; então -A gera um \'C IND. 0\'-semigrupo holomorfo em \'L POT.2\' (\'OMEGA\'). ). Em segundo lugar estudaremos a geração de semigrupo em \'C IND. 0\'(\'OMEGA\") = ) = {u \'PERTENCE A\' C (\'OMEGA\' \'BARRA\") : u[\'PARTIAL omega\' = 0} por operadores elípticos de ordem 2 com \'OMEGA\' satisfazendo uma propriedade geométrica. Mais precisamente, se \'OMEGA\' ESTA CONTIDO EM\' \'R POT. n\' (n \'> ou =\' 2) é um domínio limitado que satisfaz a condição de cone exterior uniforme, L é o operador Lu := - \\\\SIGMA SUP n INF. i,j = 1\' \'a IND. ij \'D IND. ij u + \'\\SIGMA SUP. n IND. j=1 \'b IND. j\' u + cu com coeficientes reais \'a IND. ij\' , \'b IND. j\' , c que satisfazem \'b IND. j \' \'PERTENCE A\' \'L POT. INFTY\' (\'OMEGA\') , j = 1, ..., n, c \'PERTENCE A \' \'L POT> INFTY\' (OMEGA), c \'> ou =\' 0, \'a IND. ij\' \'PERTECE A\' C(\' OMEGA BARRA)\' \' INTERSECCAO\' \'L POT. INFTY\' (OMEGA),e \'A IND. 0\' é parte de L em \'C IND. 0\' (\"OMEGA\'), isto é, D(\'A IND. 0\') = {u \'PERTENCE A\' \'C IND. 0\' (\'OMEGA\') \'INTERSECÇÂO\' \'W POT. 2, n INF. loc\' (\'OMEGA\') : Lu \'PERTENCE A\' \'C IND. 0\' (\'OMEGA\')\' \'A IND. 0\' u = Lu, então -\'A IND. 0\' gera um \'C IND. 0-semigrupo holomorfo limitado em \'C IND. 0\' (\'OMEGA\')In this work we study the generation of semigroups by elliptic operators in two spaces. Firstly we study the generation of semigroup in the space \'L POT. 2\' (OMEGA) for elliptic operators of order 2m with \'OMEGA\' regular domain. More precisely, if \'OMEGA\' is a bounded domain with \\PARTIAL OMEGA\' \'IT BELONGS\' \'C POT. 2m\', L (x, D) = \\ sigma INF.ALPHA \'> or =\' 2m, \'a IND. alpha\' ( x) \'D POT alpha\' is an elliptic differential operator of order 2m, with \'a IND. alpha\' \' \'IT BELONGS\' \'C POT. j\' (OMEGA), j = max , and A : D (A) \'THIS CONTAINED\' \'L POT. 2\' (OMEGA) \'ARROW\' \'L POT. 2\' (OMEGA) is linear operator given or D(A) = \'H POT. 2m\' (OMEGA) \'INTERSECTION\' \'H POT. m INF. 0 (OMEGA) (Au) (x) = L (x,D) u then -A generates a holomorphic \'C IND. 0\'-semigroup in \'L POT. 2\'.(OMEGA). Secondly we study the generation of semigroup in \'C IND. 0\' (OMEGA) = {u \'IT BELONGS\' (c INF. O\' (OMEGA BAR) : \'u [IND. \\partial omega\' = 0} for elliptic operators of second order with \'OMEGA\' satisfying a geometric property. That is, if \'OMEGA\' \'IT BELONGS\' \'R POT. n\' (n > or = 2) is a bounded domain that satisfies the uniform exterior cone condition, L is the elliptic operator given by Lu : = - \\SIGMA SUP. n INF. i,j = 1\' \'a IND. i, j\' \'D IND. ij \' u + \\SIGMA SUP n INF. j=1\' \'b IND j D IND j\' u + cu with real coefficients \'a IND. ij, \'b IND. j\' , c satisfying \'b ind. j\' \'IT BELONGS\' \' L POT. INFTY\' (omega), j = 1, ..., n, c \'it belongs\' \'L POT. INFTY\' (OMEGA), \'c > or =\' 0, \'\'a IND. ij \'IT BELONGS\' C (OMNEGA BAR) \'INTERSECTION\' (OMEGA), and \'A IND. 0\' is part of L in \'C IND. 0\'(OMEGA), that is, D (\'A IND. 0\') = {u \'IT BELONGS\' \'C IND. 0\' (OMEGA) INTERSECTION \'W POT. 2, n IND. loc (OMEGA)} \'A IND. 0u\' = Lu, then - \'A IND. 0\' generates a bounded holomorphic \'C IND. 0\'-semigroup on \'C IND. 0\' (OMEGA)
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Garin, Maria, and Emma Nilsson. "Effekten av omega 3 och omega 6. Är det framtidens skydd mot cancer mammae? En litteraturstudie." Thesis, Malmö högskola, Fakulteten för hälsa och samhälle (HS), 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-24329.
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Cancer mammae är den mest förekommande cancerformen hos kvinnor världen över. Etiologin är för närvarande relativt okänd. I decennier har det förts en diskussion huruvida kost har ett samband med denna fruktade cancerform. Syftet med denna systematiska litteraturstudie var att sammanställa litteratur rörande omega 3 och omega 6 för att undersöka om det finns ett samband med cancer mammae. Litteraturstudiens metod grundar sig på Forsberg & Wengström (2010). Enbart artiklar med kvantitativ design inkluderades i litteraturstudien. Granskning och kvalitetsbedömning av artiklarna gjordes individuellt och sedan gemensamt för att försäkra hög kvalitetsgrad. Tio artiklar av varierande kvalitet inkluderades i litteraturstudien. Resultatet av de tio sammanställda artiklarna tyder på att omega 3 fettsyrorna EPA och DHA har en skyddande effekt mot cancer mammae hos postmenopausala kvinnor. Fettsyran omega 6 visade inte något signifikant resultat. Ytterligare granskning av befintliga studier samt vidare forskning rörande berört ämne bör göras för att kunna implementera denna information i en evidensbaserad omvårdnad.Cancer mammae is the most common cancer among women worldwide. The etiology is currently relatively unknown. For decades there has been discussion whether the diet has a connection with this dreaded form of cancer. The purpose of this systematic review was to compile literature on omega 3 and omega 6 to examine whether there is a link with cancer mammae. Literature study's methodology is based on Forsberg & Wengström (2010). Only articles with a quantitative design were included in this study. Review and evaluate of the quality of articles were made individually and then jointly to ensure high-quality degree. Ten items of varying quality were included in this study. The results of the ten consolidated articles suggest that omega 3 fatty acids EPA and DHA have a protective effect on cancer mammae in postmenopausal women. Fatty acid omega 6 showed no significant results. Further analysis of existing studies and further research into the substance concerned should be made to implement this information in an evidence based nursing.
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Peikert, Ronald. "omega-Reguläre Sprachen und temporale Aussagenlogik /." Zürich, 1985. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=7905.
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Kraft, Anna. "Omega-3-fettsyror mot ADHD : Litteraturstudie." Thesis, Umeå universitet, Kemiska institutionen, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-66743.
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Fair, Barbara E. "An investigation of omega-phase catalysis." Diss., Georgia Institute of Technology, 1985. http://hdl.handle.net/1853/30308.
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Conroy, M. "Synthesis of #alpha#, #omega# functionalised oligomers." Thesis, Lancaster University, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.240508.
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Holmqvist, Merily. "Effekten av Omega-3 på demenssjukdom." Thesis, Högskolan i Skövde, Institutionen för biovetenskap, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-9529.
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Kännedom om Omega-3 började med att man upptäckte att omega-3 har en effekt på kardiovaskulära sjukdomar, sedan dess har man börjat utforska allt fler områden där omega-3 har visat sig ha en positiv effekt. Syftet med den här uppsatsen är att undersöka huruvida Omega-3 har en effekt på demens och den vanligaste demenssjukdomen Alzheimer. Demens orsakas bland annat av en omfattande celldöd i hjärnan och uttrycker sig genom att minnet och kognitionen blir gradvis försämrat eftersom det episodiska minnet är försämrat hos dementa. Alzheimer i sin tur har visat sig ha låga nivåer av DHA i hippocampus. Studier har visat att ett intag av fisk och Omega-3 kan förebygga en uppkomst av demens och Alzheimer och förbättra den kognitiva försämringen som sker vid demenssjukdom. Slutresultaten är motsägelsefulla. De flesta studier visar att Omega-3 påverkar och förbättrar kognitionen hos Demens och Alzheimer patienter och kan verka förebyggande och även som behandling. Emellertid finns det de studier som visar på att Omega-3 inte har visat någon signifikant effekt, eller enbart har en förebyggande effekt och endast ifall demenssjukdomen inte är starkt genetiskt betingad.
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Close, Marjory. "The chemistry of polycyclic #omega#hydroxylactams." Thesis, University of Wolverhampton, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.359669.
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Barbina, Silvia. "Automorphism groups of omega-categorical structures." Thesis, University of Leeds, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.410638.
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Quinn-Gregson, Thomas. "Homogeneity and omega-categoricity of semigroups." Thesis, University of York, 2017. http://etheses.whiterose.ac.uk/18788/.
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In this thesis we study problems in the theory of semigroups which arise from model theoretic notions. Our focus will be on omega-categoricity and homogeneity of semigroups, a common feature of both of these properties being symmetricity. A structure is homogeneous if every local symmetry can be extended to a global symmetry, and as such it will have a rich automorphism group. On the other hand, the Ryll-Nardzewski Theorem dictates that omega-categorical structures have oligomorphic automorphism groups. Numerous authors have investigated the homogeneity and omega-categoricity of algebras including groups, rings, and of relational structures such as graphs and posets. The central aim of this thesis is to forge a new path through the model theory of semigroups. The main body of this thesis is split into two parts. The first is an exploration into omega-categoricity of semigroups. We follow the usual semigroup theoretic method of analysing Green's relations on an omega-categorical semigroup, and prove a finiteness condition on their classes. This work motivates a generalization of characteristic subsemigroups, and subsemigroups of this form are shown to inherit omega-categoricity. We also explore methods for building omega-categorical semigroups from given omega-categorical structures. In the second part we study the homogeneity of certain classes of semigroups, with an emphasis on completely regular semigroups. A complete description of all homogeneous bands is achieved, which shows them to be regular bands with homogeneous structure semilattices. We also obtain a partial classification of homogeneous inverse semigroups. A complete description can be given in a number of cases, including inverse semigroups with finite maximal subgroups, and periodic commutative inverse semigroups. These results extend the classification of homogeneous semilattices by Droste, Truss, and Kuske. We pose a number of open problems, that we believe will open up a rich subsequent stream of research.
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Burgess, Lydia Anne. "Omega Production Resource: An Internship Report." ScholarWorks@UNO, 2015. http://scholarworks.uno.edu/aa_rpts/178.
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This report documents the internship of Lydia Anne Burgess with Omega Production Resource from August 2014 to March 2015. Omega is one of several event lighting companies operating in Greater New Orleans. Omega’s administrative offices are located in the Alario Center situated just inside of Bayou Segnette Park in Westwego, Louisiana. During her internship, Ms. Burgess worked under the direction of the Operations Director and the company founder and CEO. Among her various responsibilities, Ms. Burgess primarily assisted the CEO and Operations Director with administrative duties such as form creation/modernization, file organization, and scheduling. She also undertook marketing analysis for the company. An overview of Omega and of the internship is provided within this report. Additionally, this report provides an analysis of the company’s strengths, weaknesses, opportunities, and threats (S.W.O.T.), recommendations for the company based on Ms. Burgess’ observations, and an examination of best practices performed by similar companies.
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Collie, Hannah, Mary C. Mrs Andreae, and William A. Clark. "Omega-3 Fortification of Marinara Sauce." Digital Commons @ East Tennessee State University, 2021. https://dc.etsu.edu/asrf/2021/presentations/59.
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Omega-3 Fortification of Marinara Sauce
Hannah Collie, Mary Andreae, MS, RD, LDN, W. Andrew Clark, PhD, RD, LDN, Department of Rehabilitative Science,
College of Clinical and Rehabilitative Health
East Tennessee State University,
Johnson City, Tennessee
In westernized culture, there is a deficit of healthy fats in the average person’s diet. This is evidenced by many different conditions such as cardiovascular disease, cancer, and chronic inflammatory issues. The “Mediterranean Diet” has been shown as an ideal way to combat these health issues.The diet promotes fish as a protein source and a way to consume essential polyunsaturated fatty acids. Due to location and trends, fish is less often a main component of the western diet.This study investigated ways to fortify a more commonly consumed food in western culture, marinara sauce, with flaxseed oil, walnut oil, and anchovies. These fortified marinara sauces were compared to a commercial sauce, Paul Newman’s Marinara for nutritional content. We hypothesize that adding omega-3 rich ingredients to a base marinara sauce recipe will significantly vary the fatty acid profile and increase the amount of omega-3 fatty acids as well as decrease the omega-6 to omega-3 fatty acid ratio. Sauces were prepared and analyzed for nutrient content using proximate analysis methods. Preparation included cooking and freeze drying the variants. Nutrient content tests performed included: bomb calorimetry, Kjeldahl protein analysis, Soxhlet fat analysis, ash inorganic analysis, FRAP Assay for antioxidant content, and gas chromatography to characterize fatty acid composition. Each variant sauce had a fatty acid profile that was unique. Two of the three variants showed a better omega-6 to omega-3 fatty acid ratio than the (control) Paul Newman’s sauce. Samples with the highest to lowest omega-6 to omega-3 ratio were respectively, flaxseed oil, Paul Newman’s commercial sauce, walnut oil, and anchovy. From gas chromatography, omega three fatty acid composition as a percentage of total fatty acids were approximately in the flaxseed oil variant, 21% in the Paul Newman’s sauce, 30% in the walnut oil variant, and 81% in the anchovy variant. Two of three variant sauces, walnut and anchovy, when compared to the commercial Paul Newman's sauce, showed more favorable omega-3 fatty acid content and lower omega-6 to omega-3 fatty acid ratios. Unexpectedly, the flaxseed oil variant had less omega three fatty acids and a higher omega-6 to omega-3 fatty acid ratio than the commercial sauce. In conclusion, simple additions of omega-3 ingredients to marinara sauce can decrease the omega-6 to omega-3 fatty acid ratio in the diet.
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Savina, Y. "Alternative sources of getting omega 3." Thesis, Київський національний університет технологій та дизайну, 2018. https://er.knutd.edu.ua/handle/123456789/10779.
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Bernstein, Brett David. "Higher natural numbers and omega words." Diss., Online access via UMI:, 2005.
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Howard, Alicia Dawn. "Indices of stress in exercising horses fed diets containing varying amounts of omega-6 and omega-3 polyunsaturated fatty acids." Texas A&M University, 2005. http://hdl.handle.net/1969.1/2517.
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Dietary omega-3 polyunsaturated fatty acids have shown substantial benefits in
humans including lowered serum cholesterol, blood pressure and indices of stress. The
caloric and extracaloric benefits of feeding fat supplemented diets to performance horses
are well documented (Webb et al., 1987; Meyers et al., 1989; Julen et al., 1995).
However, omega-3 polyunsaturated fatty acids have not been studied to any great extent.
This study was conducted to determine the efficacy of feeding omega-3 fatty acids on
indices of stress and serum cholesterol in horses.
Nine three- and four-year old horses were assigned to diet treatments according to
sex, age and athletic ability. Concentrate diets consisted of: control (A), fatsupplemented
diet with corn oil (B) and fat-supplemented diet with extruded/expelled
soybean oil (C; N-3). Overall, heart rates were lower in horses fed the fat-supplemented
diets compared to the control diet. On reining and cutting exercise days, heart rates were
lower (P<.05) in horses fed fat-supplemented diets vs. the control diet. There were no
differences (P>.05) in heart rates during exercise on reining and cutting days between
horses fed the two fat-supplemented diets. Recovery heart rates following the SET from the end of exercise to 60 minutes recovery (R), were significantly quicker in horses fed
diet C.
Plasma cortisol concentrations were lowest in horses fed the soy oil-supplemented
diet and highest in horses fed the corn oil-supplemented diet. Across treatments, plasma
cortisol concentrations during the SET rose due to the onset of exercise and remained
significantly higher (P<.05) than baseline during the SET. Serum cholesterol
concentrations were higher in horses fed corn oil-supplemented diets than in the control
or the soy oil-supplemented diets.
There was no significant change (P>.05) in body weight between horses
consuming these three diets. However, when compared to consuming diets B and C the
horses fed diet A had higher (P<.05) concentrate intakes. There was no significant
difference in hay intake (P>.05) between horses consuming the three diets.
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Callahan, Lance Russell. "In the shadows of divine perfection, Derek Walcott's Omeros." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape9/PQDD_0016/NQ46289.pdf.
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Vieira, LÃlian Cavalcanti Fernandes. "Omeros: vozes de identidade e cultura em Derek Walcott." Universidade Federal do CearÃ, 2012. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=7979.
Full textAbstract:
nÃo hÃEste trabalho tem como objetivo investigar e analisar a questÃo da identidade e cultura de matriz africana por meio da obra do autor afro-caribenho e PrÃmio Nobel de Literatura em 1992, Derek Walcott, cuja obra ainda nÃo encontra no Brasil um estudo e divulgaÃÃo adequados. Com essa proposta, estamos cooperando com a lei no. 10.639/03 para a afirmaÃÃo do processo de consciÃncia negra por meio da busca de um processo identitÃrio que permeia os escritos do autor, analisando o entre-lugar do discurso do poeta e suas possÃveis influÃncias na produÃÃo de identidade e cultura no Brasil. Parte-se do pressuposto da pertinÃncia de se fazer uma reflexÃo sobre identidade e cultura como atos polÃticos, ao divulgar e expor a riqueza cultural afro ou afrodescendente sob uma nova Ãtica, recuperando o escravizado como sujeito de uma histÃria social, mostrando a infÃmia do escravismo e reforÃando as aÃÃes afirmativas no contexto brasileiro. O conhecimento e o estudo dessa literatura identitÃria pode contribuir tanto para a formaÃÃo de educadores como abrir caminhos para as Ãreas de filosofia da educaÃÃo brasileira pelo aprofundamento na cultura de base africana na diÃspora, servindo de aporte Ãs diversidades culturais.
The main purpose of this work is to analyze the thematic identity and culture of African basis through the work OMEROS written by the afro Caribbean writer and Literature Nobel Prize winner (1992), Derek Walcott. His work allows the focus to issues like the discussion of concepts such as identity and culture as political acts and artifacts of a good education, the affirmation of the process of black consciousness and the recovery of the enslaved one as the subject of a social history through post-colonial literature. The knowledge and study of this literature can contribute a great deal to the intellectual formation of educators as well as it may open paths to areas of philosophy of Brazilian education through the deepening in the culture of African basis during the Diaspora serving as a contribution to cultural diversity.
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VIEIRA, Lílian Cavalcanti Fernandes. "Omeros: vozes de identidade e cultura em Derek Walcott." www.teses.ufc.br, 2012. http://www.repositorio.ufc.br/handle/riufc/7652.
Full textAbstract:
VIEIRA, Lílian Cavalcanti Fernandes. Omeros: vozes de identidade e cultura em Derek Walcott. 2012. 154f. – Tese (Doutorado) – Universidade Federal do Ceará, Programa de Pós-graduação em Educação Brasileira, Fortaleza (CE), 2012.Submitted by Márcia Araújo (marcia_m_bezerra@yahoo.com.br) on 2014-03-12T17:29:18Z No. of bitstreams: 1 2012-TESE-LCFVIEIRA.pdf: 1359253 bytes, checksum: 01a1295b5eea11cc0a9f6cecb0c1f126 (MD5)
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The main purpose of this work is to analyze the thematic identity and culture of African basis through the work OMEROS written by the afro Caribbean writer and Literature Nobel Prize winner (1992), Derek Walcott. His work allows the focus to issues like the discussion of concepts such as identity and culture as political acts and artifacts of a good education, the affirmation of the process of black consciousness and the recovery of the enslaved one as the subject of a social history through post-colonial literature. The knowledge and study of this literature can contribute a great deal to the intellectual formation of educators as well as it may open paths to areas of philosophy of Brazilian education through the deepening in the culture of African basis during the Diaspora serving as a contribution to cultural diversity.
Este trabalho tem como objetivo investigar e analisar a questão da identidade e cultura de matriz africana por meio da obra do autor afro-caribenho e Prêmio Nobel de Literatura em 1992, Derek Walcott, cuja obra ainda não encontra no Brasil um estudo e divulgação adequados. Com essa proposta, estamos cooperando com a lei no. 10.639/03 para a afirmação do processo de consciência negra por meio da busca de um processo identitário que permeia os escritos do autor, analisando o entre-lugar do discurso do poeta e suas possíveis influências na produção de identidade e cultura no Brasil. Parte-se do pressuposto da pertinência de se fazer uma reflexão sobre identidade e cultura como atos políticos, ao divulgar e expor a riqueza cultural afro ou afrodescendente sob uma nova ótica, recuperando o escravizado como sujeito de uma história social, mostrando a infâmia do escravismo e reforçando as ações afirmativas no contexto brasileiro. O conhecimento e o estudo dessa literatura identitária pode contribuir tanto para a formação de educadores como abrir caminhos para as áreas de filosofia da educação brasileira pelo aprofundamento na cultura de base africana na diáspora, servindo de aporte às diversidades culturais.
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CHHEN, ABDEL-ILAH. "Utilisation des omega-azidoalkylidenetriphenylphosphorannes et des carbanions en alpha-des omega-aminosulfones comme reactifs pour l'aminoalkylation nucleophile." Rennes 1, 1989. http://www.theses.fr/1989REN10078.
Full textAbstract:
Synthese stereoselective d'-azidoolefines (z), d'-azidodienes (e, z), d'amines primaires ou secondaires -insaturees et d'amines primaires saturees. Utilisation des -aminosulfones bis-metallees comme reactifs pour l'aminoalkylation nucleophile. Elimination reductrice du groupe benzenesulfonyl dans les produits de monoalkylation et les -hydroxysulfones obtenues pour donner des amines primaires eventuellement -insaturees
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Alghamdi, Fatmah. "ANALYSIS OF THE OMEGA-3 FATTY ACIDS CONTENT IN COMMERCIAL OMEGA-3 SUPPLEMENTS IN ARAB GULF COUNTRIES." OpenSIUC, 2019. https://opensiuc.lib.siu.edu/theses/2571.
Full textAbstract:
The consumption of omega-3 fatty acids has increased over the past years for multiple reported health benefits. The omega-3 fatty acids of particular interest are eicosatetraenoic acid (C20:5n3; EPA) and docosahexaenoic acid (C22:6n3; DHA). High quality supplements are essential for safe intake. Studies from different countries including the United States and South Africa showed discrepancies between measured versus the claimed content of EPA and/or DHA in omega-3 supplements sold in Arab Gulf Countries. Therefore, the objective of this study was to analyze and compare the EPA and DHA content of omega-3 supplements with the contents claimed on the product label. Thirty-one commercial supplements purchased from stores in 3 different countries (Saudi Arabia, Kuwait, and Bahrain) had their fatty acid composition and content were analyzed using Gas- Chromatograph with a 100-m SP-2560 fused silica capillary column. The range of measured EPA was 5.09 mg to 469.63 mg per capsule and for DHA was 10.47 to 357.26 mg per capsule. The percentage of the stated label amount for EPA and DHA ranged from 6.5 to 138.6% and 10.9 to 126.3%, respectively. Using the U.S. Food and Drug Administration (FDA) labeling requirements where a supplement must contain at least 80% of the stated label amount of each component listed, only 43.8% of the supplements were compliant for EPA and 40.6% were compliant for DHA. Additionally, only 21.9% of the measured EPA and DHA fall within the 10% of the stated label amount. These results demonstrate the wide variability between the stated label amounts of EPA and DHA in omega-3 supplements sold in Arab Gulf Countries and the need for governmental agencies to perform testing to ensure compliance.
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Franko, Bettina. "Use of Dietary Supplementation of Unsaturated Fatty Acids to Delay Onset of Learning and Memory Deficits in TgCRND8 Mice." Thesis, Université d'Ottawa / University of Ottawa, 2014. http://hdl.handle.net/10393/31933.
Full textAbstract:
Alzheimer’s disease (AD) is a complex neurodegenerative disorder, involving metabolic dysfunction, pathogenic aggregation of amyloid beta, and deteriorating cognitive function. Patients exhibit deficiency in omega-3,-6,-9 unsaturated fatty acids (UFAs) in plasma and brain membrane phospholipids, suggesting aberrant fatty acid metabolism influences pathology. Cognitive benefits of omega UFAs in AD remain unknown. Here, I examined effects of a four-month dietary supplementation with UFAs for capacity to alter learning and memory behaviour in an AD mouse model. Cognitive impairment in a fifth generation backcross (N5) C57BL/6Crl X C3H/HeJ TgCRND8 (Tg) mice was compared to control (NonTg) littermates, with respect to both males and females, at six months of age using the Morris Water Maze (MWM). Impairment differed between sexes; female Tg mice were severely impaired, whereas male Tg mice displayed delayed learning. A reduced visual acuity in Tg and NonTg mice, shown by adapted SLAG reflex test, did not impair spatial navigation in cued MWM. A four-month omega-6/-9 UFA oral treatment (75 mg/kg/day) improved learning and memory of Tg mice as compared to vehicle and untreated controls. Omega-3 UFAs, or vehicle alone, did not alter learning and memory of Tg and NonTg mice. Thus, dietary supplementation, particularly when enriched in omega-6/9 UFAs, can affect neural function, and delay conversion from a presymptomatic to symptomatic state in the TgCRND8 mouse model.
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Bittner, Daniel. "Der Einfluss eines mit Omega-3 Fettsäuren angereicherten Nahrungsmittels auf den Omega-3 Index bei Patienten mit Atherosklerose." Diss., lmu, 2011. http://nbn-resolving.de/urn:nbn:de:bvb:19-135626.
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Ogle, Mark Edward. "Spectroscopic studies of [alpha],[omega]-diphenylpolyenyl anions." Diss., Georgia Institute of Technology, 1990. http://hdl.handle.net/1853/30363.
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Barwell, Andrew David. "Omega-Limit Sets of Discrete Dynamical Systems." Thesis, University of Birmingham, 2011. http://etheses.bham.ac.uk//id/eprint/1476/.
Full textAbstract:
Omega-limit sets are interesting and important objects in the study of discrete dynamical systems. Using a variety of methods, we present and extend existing results in this area of research. Of particular interest is the property of internal chain transitivity, and we present several characterizations of omega-limit sets in terms of this property. In so doing, we will often focus our attention on the property of pseudo-orbit tracing (shadowing), which plays a central role in many of the characterizations, and about which we prove several new results. We also make extensive use of symbolic dynamics, and prove new results relating to this method of analysis.
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Ackerman, Nathaniel Leedom. "Quantifier rank spectrum of L-infinity-omega." Thesis, Massachusetts Institute of Technology, 2006. http://hdl.handle.net/1721.1/34269.
Full textAbstract:
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Mathematics, 2006.This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.
Includes bibliographical references (p. 321) and index.
In Part A we will study the quantifier rank spectrum of sentences of L!1,!. We will show that there are scattered sentences with models of arbitrarily high but bounded quantifier rank. We will also consider the case of weakly scattered and almost scattered sentences, and we will make some conjectures. In Part B we will look at a new method of induction in the case of sheaves. We will then use this method to generalize the classical proof of the Suslin-Kleene Separation Theorem to the context of sheaves on a partial Grothendieck topology.
by Nathaniel Leedom Ackerman.
Ph.D.
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Lalia, Antigoni. "Omega-3 fatty acids to combat sarcopenia." Thesis, College of Medicine - Mayo Clinic, 2016. http://pqdtopen.proquest.com/#viewpdf?dispub=10124986.
Full textAbstract:
Background: Age-related sarcopenia leads to frailty, physical disability and loss of independence. Although exercise is an effective strategy to counteract the prevailing loss of muscle mass, older adults exhibit blunted anabolic responses, and are often unable to adopt an active lifestyle due to comorbidities associated with aging. Long chain polyunsaturated fatty acids (n-3 PUFA), eicosapentaenoic (EPA) and docosahexaenoic (DHA) acid, are non-pharmaceutical nutrients which have surfaced for their potential anabolic properties on skeletal muscle and may be particularly beneficial in the context of sarcopenia.
Objective: First, to determine if EPA and DHA increase muscle protein synthesis in older adults. Second, to determine if n-3 PUFA increase the anabolic response to an acute resistance exercise stimulus in older adults. Third, to assess if their effect is mediated through improved mitochondrial function, which is known to be impaired with aging.
Methods: Twelve old, sedentary, healthy women and men (65-85 years) were given 3.9 grams/day purified EPA/DHA for 4 months. 12 young adults (18-35 years) were included as a comparison group for baseline measurements. Muscle protein fractional synthesis rate (FSR) was measured before and after treatment for mixed muscle, and subcellular fractions of myofibrillar, mitochondrial and sarcoplasmic proteins. We infused a stable isotope tracer of [ring- 13C6] phenylalanine and monitored incorporation of the amino acid into muscle proteins, at the fasting, post absorptive state, and 16 hours following an acute bout of unaccustomed resistance exercise, using mass spectrometry. Muscle mitochondrial function was assessed ex vivo from skeletal muscle biopsies. Further mechanistic information was generated through large scale and individual mRNA gene expression, inflammatory markers, and protein phosphorylation signaling of the anabolic pathway.
Results: Protein synthesis was similar between age groups at baseline and post exercise, despite the robust decline in mRNA gene expression with aging. EPA/DHA supplementation increased total lean mass, and increased mitochondrial and sarcoplasmic FSR at baseline. Following acute exercise, mixed muscle and subcellular FSR did not change significantly, but participants were segregated into responders and non-responders. EPA/DHA further potentiated the anabolic response of mitochondrial FSR to levels greater than that in the young. There was no improvement in mitochondrial oxidative capacity and efficiency, but there was a significant decrease in ROS emissions.
Conclusion: In healthy older adults, EPA/DHA exhibited significant anabolic effect in baseline skeletal muscle mitochondrial and sarcoplasmic FSR, which was dissociated from mitochondrial oxidative capacity. The anabolic response to exercise was variable between responders and non-responders where some individuals presented with marked increase in mixed muscle and subcellular FSR. This observation sets the ground for identifying the phenotypic traits of the elderly who are likely to benefit from the therapeutic use of n-3 PUFA to combat sarcopenia of aging.
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O'Shea, Karen Michelle. "Omega-3 Fatty Acids and Heart Failure." Case Western Reserve University School of Graduate Studies / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=case1258128805.
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Crego, García María. "Toledo en época Omeya (ss. VIII-X) /." Toledo : Diputación provincial de Toledo, 2007. http://catalogue.bnf.fr/ark:/12148/cb412744443.
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Xia, Ziqi. "Comparative Study of Open-Source Performance Testing tools versus OMEXUS." Thesis, KTH, Skolan för elektroteknik och datavetenskap (EECS), 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-302650.
Full textAbstract:
With the development of service digitalization and the increased adoption of web services, modern large-scale software systems often need to support a large volume of concurrent transactions. Therefore, performance testing focused on evaluating the performance of systems under workload has gained greater attention in current software development. Although there are many performance testing tools available for providing assistance in load generation, there is a lack of a systematic evaluation process to provide guidance and parameters for tool selection for a specific domain. Focusing on business operations as the specific domain and the Nasdaq Central Securities Depository (NCSD) system as an example of large-scale software systems, this thesis explores opportunities and challenges of existing open- source performance testing tools as measured by usability and feasibility metrics. The thesis presents an approach to evaluate performance testing tools concerning requirements from the business domain and the system under test. This approach consists of a user study conducted with four quality assurance experts discussing general performance metrics and specific analytical needs. The outcome of the user study provided the assessment metrics for a comparative experimental evaluation of three open-source performance testing tools (JMeter, Locust, and Gatling) with a realistic test scenario. These three tools were evaluated in terms of their affordance and limitations in presenting analytical details of performance metrics, efficiency of load generation, and ability to implement realistic load models. The research shows that the user study with potential tool users provided a clear direction when evaluating the usability of the three tools. Additionally, the realistic test case was sufficient to reveal each tool’s capability to achieve the same scale of performance as the Nasdaq’s in-house testing tool OMEXUS and provide additional value with realistic simulation of user population and user behavior during performance testing with regard to the specified requirements.Med utvecklingen av tjänste-digitalisering och ökad användning av webbtjänster behöver moderna storskaliga mjukvarusystem ofta stödja en stor mängd samtidiga transaktioner. Prestandatestning med fokus på att utvärdera prestanda för system under arbetsbelastning har därför fått större uppmärksamhet i den aktuella programvaru utvecklingen. Även om det finns många verktyg för prestandatestning tillgängliga för att ge hjälp i belastnings generering, saknas det en systematisk utvärderingsprocess för att ge vägledning och parametrar för verktygsval för en viss domän. Med fokus på affärsverksamhet som den specifika domänen och Nasdaq Central Securities Depository (NCSD) -systemet, som ett exempel på storskaliga mjukvarusystem, utforskar denna avhandling möjligheter och utmaningar med befintliga verktyg för prestandatestning med öppen källkod mätt med användbarhets- och genomförbarhet mått. Avhandlingen presenterar ett tillvägagångssätt för att utvärdera prestandatestverktyg avseende krav från företagsdomänen och det system som testas. Detta tillvägagångssätt består av en användarstudie utförd med fyra kvalitetssäkringsexperter som diskuterar allmänna prestandamått och specifika analytiska behov. Resultatet av användarstudien gav bedömningsmåtten för en jämförande experimentell utvärdering av tre verktyg för prestandatestning med öppen källkod (JMeter, Locust och Gatling) med ett realistiskt testscenario. Dessa tre verktyg utvärderades i termer av deras överkomlighet och begränsningar när det gäller att presentera analytiska detaljer om prestandamått, effektiviteten i lastgenereringen och förmågan att implementera realistiska belastningsmodeller. Forskningen visar att användarstudien med potentiella verktygsanvändare gav en tydlig riktning vid utvärdering av användbarheten av de tre verktygen. Dessutom var det realistiska testfallet tillräckligt för att avslöja varje verktygs förmåga att uppnå samma skala av prestanda som Nasdaqs interna testverktyg OMEXUS och ge ytterligare värde med realistisk simulering av användarpopulation och användarbeteende under prestandatestning med avseende på de angivna kraven.