Dissertations / Theses on the topic 'Oligosaccharide Synthesi'
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SINGH, MEENAKSHI. "Synthesis of Group B Streptococcus tipe II (GBSII) Oligosaccharide of Vaccine Development." Doctoral thesis, Università degli Studi di Milano, 2019. http://hdl.handle.net/2434/680023.
Full textFusari, M. M. "SYNTHESIS OF FRAGMENTS OF SALMONELLA TYPHI CAPSULAR POLYSACCHARIDE AND THEIR ZWITTERIONIC ANALOGUES." Doctoral thesis, Università degli Studi di Milano, 2014. http://hdl.handle.net/2434/243479.
Full textRuffing, Anne M. "Metabolic engineering and omics analysis of Agrobacterium sp. ATCC 31749 for oligosaccharide synthesis." Diss., Georgia Institute of Technology, 2010. http://hdl.handle.net/1853/39507.
Full textWatts, Christopher Rohan. "Synthesis of complex oligosaccharide." Thesis, University of Cambridge, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.624487.
Full textLe, Guen Yann. "Synthèse de fragments diversement acétylés des polysaccharides spécifiques des bactéries Shigella flexneri type I." Thesis, Sorbonne Paris Cité, 2015. http://www.theses.fr/2015USPCB143.
Full text700,000 children die each year due to diarrheal diseases, making it the second cause of death among this population. Shigella flexneri is a Gram negative enterobacterium responsible of the endemic form of shigellosis in developing countries. The O-antigen part of the bacterial lipopolysaccharide is the major target of the immune system during natural infection. The O-antigen of S. flexeni 1b, one of the prevalent serotypes, is defined by a ramified pentasaccharide made of three L-rhamnose, one D-glucosamine and one D-glucose with two non-stoichiometric sites for acetylation (I). This work is part of the project aimed at the development of a synthetic carbohydrate-based vaccine against Shigella infections. In order to obtain suitable glyconjugates inducing a high level of protection especially in children, the synthesis of mono- to pentasaccharide precursors was optimized, allowing a convergent synthesis of oligosaccharides with different acetylation patterns. Optimization of the glycosylation conditions, acetylations and protecting group manipulations enable the access to fragments from di to pentadecasaccharides representing S. flexneri type I O-antigen
Drouin, Ludovic. "New methodology for oligosaccharide synthesis." Thesis, University of Oxford, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.444903.
Full textBelogi, Gianluca. "Boronate esters in oligosaccharide synthesis." Thesis, University of Birmingham, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.367628.
Full textPatikis, Angela. "Enzymic studies of oligosaccharide synthesis." Thesis, University of Westminster, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.319626.
Full textDavis, Nicola Jane. "Synthesis of sulphated oligosaccharides." Thesis, University of Oxford, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.259866.
Full textNilsson, Magnus. "Chemical synthesis of oligosaccharide bacterial antigens /." Uppsala : Swedish Univ. of Agricultural Sciences (Sveriges lantbruksuniv.), 1999. http://epsilon.slu.se/avh/1999/91-576-5738-6.pdf.
Full textCancogni, D. "MICROFLUIDIC REACTOR TECHNOLOGY IN OLIGOSACCHARIDE SYNTHESIS." Doctoral thesis, Università degli Studi di Milano, 2014. http://hdl.handle.net/2434/229555.
Full textThomas, Baptiste. "Conception et synthèse d'hétéroglycoclusters pour l'immunothérapie anticancéreuse." Thesis, Grenoble, 2014. http://www.theses.fr/2014GRENV037/document.
Full textCancer is a major cause of mortality worldwide. Even if the rate of deaths has decreased thanks to early diagnostics and the creation of a variety of treatments, reccurence happen frequently. Among the main treatments, chimiotherapy shows a very high toxicity and radiotherapy often leads to the destruction of healthy cells, while released tumors can be left around by surgery. Immunotherapy offers a very interesting alternative to fight cancer. The development of therapeutical and/or prophylactical vaccines, able to treat and protect against tumors, seems to be an ambitious goal. Our team has recently described a new generation of synthetical vaccines which involve in the same molecule an oligosaccharide cluster (B cells epitopes), a chimer peptide (T cells epitopes) and a palmitic acid (adjuvant), bound on its N-terminal end. Immunological studies have revealed a reduction of the tumor size and a spectacular increase of the survival rate on mice, without having to administrate any extern adjuvant. On the basis of these studies, our goal has been to develop a chemical approach which would give access to more sophisticated and more immunogenic structures. To do this, we have developed methodologies of chemoselective synthesis, such as oxime ligation, Cu(I) catalysed alkyne-azide cycloaddition, (CuAAc), the thiol-chloroacétyle (TCC) and/or the thiol-ène coupling (TEC), to prepare homoglycoclusters (4-, 16- or 64- valent) or heteroglycoclusters of variable combination (2+2, 3+1, 4+2, 4x1, 8+8, 4x4) via different kind of chemical links (oxime, triazole, thioéther). These methods have been applied to the synthesis of vaccine candidates having the same carbohydrate Tn and/or TF and an immunostimulating peptide. Some biological studies with bacterial (LecB) or vegetal (UEA-I) lectines have been realised to highlight the glycosylated compounds's templates (Fuc, Man, Gal) synthesized during this PhD and have revealed nanomolar ligands. The immunological studies currently in progress on our vaccine candidates will help to understand the influence of the linker, the valence and the antigen composition on the immune response created
Greenwell, David Robert. "Template directed synthesis of oligosaccharides." Thesis, University of Leeds, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.275698.
Full textHorrobin, Tina M. "The chemoenzymatic synthesis of oligosaccharides." Thesis, University of Warwick, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.307318.
Full textWilstermann, Michael. "Synthesis of conformationally restricted oligosaccharides." Lund : Dept. of Organic Chemistry 2, Lund University, 1997. http://catalog.hathitrust.org/api/volumes/oclc/39751534.html.
Full textFrance, Robert. "An electrochemical approach to selective oligosaccharide synthesis." Thesis, University of Oxford, 2004. http://ora.ox.ac.uk/objects/uuid:d46602e8-b05a-4791-8a31-ac92a42fb93d.
Full textYao, Yanping. "Study on chemical synthesis in chitin oligosaccharide analogues β-1, 3-N-acetyl-glucosamine oligosaccharides and their induced resistance of plants to diseases." Paris 6, 2006. http://www.theses.fr/2006PA066589.
Full textSchmidt, Dirk. "Chemoenzymatische Synthese sialylierter Oligosaccharidstrukturen durch Transglycosylierung." [S.l.] : [s.n.], 2000. http://deposit.ddb.de/cgi-bin/dokserv?idn=962775215.
Full textQian, Xiangping. "Enzymatic and chemical synthesis of oligosaccharide analogs." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0013/NQ60015.pdf.
Full textWhitaker, Simon Richard. "Applications of Ionic Liquids to Oligosaccharide Synthesis." Thesis, University of Bristol, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.629002.
Full textFranz, Andreas H. "Oligosaccharide mimics: Synthesis, characterization and biological properties." Scholarly Commons, 2000. https://scholarlycommons.pacific.edu/uop_etds/2752.
Full textWright, Karen. "Synthesis of oligosaccharides affecting cell adhesion." Thesis, University College London (University of London), 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.267483.
Full textMacManus, D. A. "Enzymatic synthesis of glycosides and oligosaccharides." Thesis, University of Warwick, 1991. http://wrap.warwick.ac.uk/110506/.
Full textBaeschlin, Daniel Kaspar. "Butanediacetals in oligosaccharide synthesis : total synthesis of a GPI anchor." Thesis, University of Cambridge, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.621500.
Full textPfister, Hélène. "Synthèse d'oligosaccharides représentatifs de l'antigène O de Shigella sonnei." Thesis, Paris 5, 2014. http://www.theses.fr/2014PA05P619.
Full text800,000 children die each year of diarrhoeal diseases, making it the second cause of death among children under five. Shigellosis, caused by a Gram negative bacterium, Shigella, is one of the four major forms of diarrhoeal diseases in this population. Natural infection protects against reinfection and the humoral response is primarily directed against the specific polysaccharide moiety of the bacterial lipopolysaccharide. S. sonnei, the prevalent species in developed and transitional countries, displays a zwitterionic polysaccharide, whose disaccharide repeating unit is made of two rare aminosugars: a 2-acetamido-2-deoxy-L-altruronic acid (A) and a 2-acetamido-4-amino-2,4,6-trideoxy-D-galactose (B, AAT) 1,2-trans linked to one another (I). ->4-a-L-AltpNAcA-(1->3)-b-D-FucpNAc4N-(1-> (I). This work is part of the program aimed at the development of a synthetic carbohydrate-based broad coverage vaccine against Shigella infections. In order to define the protective epitopes located on the O-specific polysaccharide of S. sonnei, we tackled the synthesis of fragments thereof. First, multigram-scale syntheses of orthogonally protected precursors to residues A and B were undertaken to access donor and acceptor intermediates in the glycosylation reactions. In particular, two original routes to precursors of residue B were developed. Careful optimisation of the glycosylation and oxidation reaction conditions gave the disaccharide building block AB equipped for the synthesis of chain extension at both ends. Selected mono- and disaccharide building blocks were validated by the synthesis of four disaccharides, bearing modification of the charge pattern or not, two trisaccharides and a tetrasaccharide
Saliba, Regis C. "Design and synthesis of nanoparticles functionalised with Lewis oligosaccharides for selective targeting of DC-SIGN." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:21906fcb-b29f-415b-a1b7-bca375f06a2b.
Full textMason, Joanne Sheri. "Fluorescent tag methodology in enzyme-catalysed oligosaccharide synthesis." Thesis, University of Warwick, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.342692.
Full textLam, Son Ngoc. "Glycosyl iodides : a modern tool for oligosaccharide synthesis /." For electronic version search Digital dissertations database. Restricted to UC campuses. Access is free to UC campus dissertations, 2003. http://uclibs.org/PID/11984.
Full textObuchowska, Agnes K. "Acyl transfer in chemical synthesis of oligosaccharides." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp01/MQ34056.pdf.
Full textWacowich-Sgarbi, Shirley Ann. "Synthesis and conformational studies of constrained oligosaccharides." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0013/NQ60036.pdf.
Full textHall, Jonathan David. "Studies towards the combinatorial synthesis of oligosaccharides." Thesis, University of East Anglia, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.361723.
Full textNatunen, Jari. "Enzymatic synthesis of known and novel oligosaccharides." Helsinki : University of Helsinki, 1999. http://ethesis.helsinki.fi/julkaisut/mat/bioti/vk/natunen/.
Full textClaisse, Nathalie. "Préparation et modification d'oligosaccharides de cellulose par chimie douce bio-inspirée." Phd thesis, Université de Grenoble, 2012. http://tel.archives-ouvertes.fr/tel-00849149.
Full textCHEN, WENDY YUNTIEN. "SYNTHESIS AND OLIGOSACCHARIDE PROCESSING OF IMMUNOGLOBULIN-M DURING B-CELL DIFFERENTIATION." Diss., The University of Arizona, 1987. http://hdl.handle.net/10150/184207.
Full textApanga, Ludovic. "Mise au point de procédés de préparation d'oligosaccharides contenant du fucose à partir d'exopolysaccharides issus de souches mutées de bactéries du sol." Amiens, 2008. http://www.theses.fr/2008AMIE0116.
Full textL-fucose and oligosaccharides containing of L-fucose present interesting biological properties notably in the prevention of the metastases, in the reaction of inflammation, in the treatment of rheumatoid arthritics, in the vaccination (antigens) and in the cosmetic domain against the dehydration of the skin. A production of L-fucose as of oligosaccharides containing of L-fucose with the aim of their use in therapies, pushed numerous laboratories to a screening of organisms synthetizing polysaccharides containing of L-fucose. Our work, concerned first of all the production of the polysaccharides by Sinorhizobium M5N1 cPRK290 noted N and Enterobacter noted Sc strains, later these polysaccharides were characterized. And secondly we produced oligosaccharides containing of L-fucose from polysaccharides. This production of oligosaccharides required the use of several methods (acid hydrolysis, thermal hydrolysis, in the medium of culture and enzymatic degradation). The enzymatic method allows to obtain oligosaccharides in a reproducible way
Blomberg, Lennart. "Synthesis, coupling and use of oligosaccharides in affinity chromatography." Lund : Organic Chemistry 2, Lund Institute of Technology, Lund University, 1994. http://books.google.com/books?id=-A1rAAAAMAAJ.
Full textNieder, Veronika. "Glycosidase-katalysierte Synthese und Charakterisierung von Nucleotid-Di- und Oligosacchariden." [S.l. : s.n.], 2001. http://deposit.ddb.de/cgi-bin/dokserv?idn=962322776.
Full textGagné, Rodney A. "Design, synthesis and evaluation of high affinity oligosaccharide ligands." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0012/NQ59963.pdf.
Full textChindarkar, Nandkishor S. "Synthesis, characterization, and application of novel multifunctional oligosaccharide tags." Scholarly Commons, 2008. https://scholarlycommons.pacific.edu/uop_etds/2378.
Full textMaosah, Charity Kwamboka. "Enhancing transglycosylation reaction by minimizing hydrolysis in oligosaccharide synthesis." Youngstown State University / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=ysu161990153240475.
Full textYamada, Takeshi. "A new iterative strategy of oligosaccharide synthesis using chalcogenoglycosides." 京都大学 (Kyoto University), 2006. http://hdl.handle.net/2433/144037.
Full text0048
新制・課程博士
博士(工学)
甲第12353号
工博第2682号
新制||工||1379(附属図書館)
24189
UT51-2006-J345
京都大学大学院工学研究科合成・生物化学専攻
(主査)教授 吉田 潤一, 教授 村上 正浩, 教授 杉野目 道紀
学位規則第4条第1項該当
Ellervik, Ulf. "Synthetic analogs of sialyl Lewis x." Lund : Lund University, 1998. http://catalog.hathitrust.org/api/volumes/oclc/68945019.html.
Full textChassagne, Pierre. "En route vers des glycoconjugués à potentiel vaccinal contre la dysenterie bacillaire : synthèse d'oligosaccharides représentatifs de l'antigène O de Shigella flexneri sérotype 6." Thesis, Paris 5, 2012. http://www.theses.fr/2012PA05P603.
Full textNazabadioko, Serge. "Synthese d'oligosaccharides pour l'hemisynthese de saponines." Reims, 1996. http://www.theses.fr/1996REIMP202.
Full textUnderwood, Melanie. "The synthesis of oligosaccharides related to heparan sulphate." Thesis, University of Oxford, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.359986.
Full textLove, Kerry Routenberg 1977. "Automated synthesis of the Lewis blood group oligosaccharides." Thesis, Massachusetts Institute of Technology, 2004. http://hdl.handle.net/1721.1/17827.
Full textVita.
Includes bibliographical references.
Cell-surface carbohydrates are markers of specific cell types. These oligosaccharides are involved in recognition, adhesion, and signal transduction events. Advances in molecular glycobiology rely heavily on straightforward access to structurally defined oligosaccharides, but traditional syntheses of complex carbohydrates have been very laborious. Development of a novel linker and monitoring of each glycosylation reaction during automated solid-phase oligosaccharide synthesis allowed for the rapid synthesis of three Lewis-type cell surface oligosaccharides. The assembly of the nonasaccharide adenocarcinoma marker Le[superscript]y-Le[superscript]x monosaccharide building blocks was achieved in just 23 hours, while the syntheses of the tumor markers Lewis X, a pentasaccharide, and Lewis Y, a hexasaccharide, required only 12 and 14 hours respectively. The automation of carbohydrate synthesis greatly accelerates access to molecules for biological study and vaccine development.
by Kerry Routenberg Love.
Ph.D.
Bouhall, Samantha K. "Preactivation Glycosylation of Oligosaccharide Molecular Probes for the Investigation of Mycobacterium tuberculosis Enzyme GlgE." University of Toledo / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1449787207.
Full textRolland, David. "Nanofluidique de solutions polymériques appliquées à la synthèse in situ d'oligosaccharides." Phd thesis, Université de Grenoble, 2012. http://tel.archives-ouvertes.fr/tel-00721738.
Full textCumpstey, Ian. "The stereospecific formation of 1,2-cis glycosides via allyl-mediated intramolecular aglycon delivery." Thesis, University of Oxford, 2002. http://ora.ox.ac.uk/objects/uuid:2c4e0fb3-5a43-473a-bfbb-43557f19ffe9.
Full textDouglas, N. L. "Tuning glycoside reactivity : a new tool for efficient oligosaccharide synthesis." Thesis, University of Cambridge, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.598613.
Full text