Relevant bibliographies by topics / Olfactory tissue

Academic literature on the topic 'Olfactory tissue'

Author: Grafiati
Published: 4 June 2021
Last updated: 9 February 2022

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Contents

Consult the lists of relevant articles, books, theses, conference reports, and other scholarly sources on the topic 'Olfactory tissue.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Journal articles on the topic "Olfactory tissue"

1

Nishizaki, Kazunori. "Olfactory Tissue and Regeneration Medicine." Practica Oto-Rhino-Laryngologica 104, no. 5 (2011): 309–15. http://dx.doi.org/10.5631/jibirin.104.309.

Full text
APA, Harvard, Vancouver, ISO, and other styles
2

Makino, N., S. Ookawara, S. Madoiwa, Y. Ohta, T. Ishikawa, K. Katoh, S. Takigami, et al. "Morphological assessment of the luminal surface of olfactory epithelium in mice deficient in tissue plasminogen activator following bulbectomy." Journal of Laryngology & Otology 126, no. 11 (September 19, 2012): 1114–20. http://dx.doi.org/10.1017/s002221511200206x.

Full text
Abstract:
AbstractObjective:This study aimed to investigate the function of tissue plasminogen activator in the olfactory epithelium of mice following neural injury.Method:Transmission electron microscopy was used to study the changes in the morphology of the olfactory epithelium 1–7 days after surgical ablation of the olfactory bulb (bulbectomy).Results:Prior to bulbectomy, a uniformly fine material was observed within some regions of the olfactory epithelium of mice deficient in tissue plasminogen activator. At 2–3 days after bulbectomy, there were degenerative changes in the olfactory epithelium. At 5–7 days after bulbectomy, we noted drastic differences in olfactory epithelium morphology between mice deficient in tissue plasminogen activator and wild-type mice (comparisons were made using findings from a previous study). The microvilli seemed to be normal and olfactory vesicles and receptor neuron dendrites were largely intact in the olfactory epithelium of mice deficient in tissue plasminogen activator.Conclusion:The tissue plasminogen activator plasmin system may inhibit the regeneration of the olfactory epithelium in the early stages following neural injury.
APA, Harvard, Vancouver, ISO, and other styles
3

Biedlingmaier, John F., and Philip J. Whelan. "Analysis for Olfactory Epithelium using Olfactory Marker Protein on Endoscopically Harvested Middle Turbinates." American Journal of Rhinology 10, no. 4 (July 1996): 221–24. http://dx.doi.org/10.2500/105065896782103144.

Full text
Abstract:
The middle turbinate is thought to play a key role in olfaction, and many surgeons have cautioned against removal of the middle turbinate during endoscopic sinus surgery. We reviewed 110 patients having 198 partial middle turbinate resections and found that only one patient complained of postoperative anosmia (0.9%). To further investigate the presence of olfactory tissue on the middle turbinate, 36 sections from 12 endoscopically resected turbinate specimens were stained for olfactory tissue, using olfactory marker protein (OMP). Cadaveric olfactory cleft specimens served as positive controls. Neither olfactory epithelium nor olfactory receptor cells were identified in the surgical specimens. The clinical rarity of anosmia suggests that partial resections must not adversely affect airflow to the olfactory cleft. The histologic data suggest that conservative partial turbinate resections should not affect olfaction directly, either because olfactory tissue is not removed by this maneuver, or because the amount of olfactory tissue in this segment is minimal.
APA, Harvard, Vancouver, ISO, and other styles
4

Menco, Bert Ph M. "Ultrastructural aspects of olfactory signal transduction and its development." Proceedings, annual meeting, Electron Microscopy Society of America 52 (1994): 142–43. http://dx.doi.org/10.1017/s042482010016844x.

Full text
Abstract:
Vertebrate olfactory receptor cells are specialized neurons that have numerous long tapering cilia. The distal parts of these cilia line the interface between the external odorous environment and the luminal surface of the olfactory epithelium. The length and number of these cilia results in a large surface area that presumably increases the chance that an odor molecule will meet a receptor cell. Advanced methods of cryoprepration and immuno-gold labeling were particularly useful to preserve the delicate ultrastructural and immunocytochemical features of olfactory cilia required for localization of molecules involved in olfactory signal-transduction. We subjected olfactory tissues to freeze-substitution in acetone (unfixed tissues) or methanol (fixed tissues) followed by low temperature embedding in Lowicryl K11M for that purpose. Tissue sections were immunoreacted with several antibodies against proteins that are presumably important in olfactory signal-transduction.
APA, Harvard, Vancouver, ISO, and other styles
5

Sindwani, R. "Immunohistochemical Characterization of Human Olfactory Tissue." Yearbook of Otolaryngology-Head and Neck Surgery 2012 (January 2012): 190–92. http://dx.doi.org/10.1016/j.yoto.2012.03.020.

Full text
APA, Harvard, Vancouver, ISO, and other styles
6

Holbrook, Eric H., Enming Wu, William T. Curry, Derrick T. Lin, and James E. Schwob. "Immunohistochemical characterization of human olfactory tissue." Laryngoscope 121, no. 8 (July 25, 2011): 1687–701. http://dx.doi.org/10.1002/lary.21856.

Full text
APA, Harvard, Vancouver, ISO, and other styles
7

SCHULZE, D. H., M. PYRSKI, A. RUKNUDIN, J. W. MARGOLIS, S. K. POLUMURI, and F. L. MARGOLIS. "Sodium-Calcium Exchangers in Olfactory Tissue." Annals of the New York Academy of Sciences 976, no. 1 (January 24, 2006): 67–72. http://dx.doi.org/10.1111/j.1749-6632.2002.tb04716.x.

Full text
APA, Harvard, Vancouver, ISO, and other styles
8

McClintock, Timothy S., Chad E. Glasser, Soma C. Bose, and Daniel A. Bergman. "Tissue expression patterns identify mouse cilia genes." Physiological Genomics 32, no. 2 (January 2008): 198–206. http://dx.doi.org/10.1152/physiolgenomics.00128.2007.

Full text
Abstract:
In mammals, cilia are critical for development, sensation, cell signaling, sperm motility, and fluid movement. Defects in cilia are causes of several congenital syndromes, providing additional reasons to identify cilia-related genes. We hypothesized that mRNAs selectively abundant in tissues rich in highly ciliated cells encode cilia proteins. Selective abundance in olfactory epithelium, testes, vomeronasal organ, trachea, and lung proved to be an expression pattern uniquely effective in identifying documented cilia-related genes. Known and suspected cilia-related genes were statistically overrepresented among the 99 genes identified, but the majority encoded proteins of unknown function, thereby predicting new cilia-related proteins. Evidence of expression in a highly ciliated cell, the olfactory sensory neuron, exists for 73 of the genes. In situ hybridization for 17 mRNAs confirmed expression of all 17 in olfactory sensory neurons. Most were also detected in vomeronasal sensory neurons and in neighboring tissues rich in ciliated cells such as respiratory epithelium. Immunoreactivity for one of the proteins identified, Spa17, colocalized with acetylated tubulin in the cilia layer of the olfactory epithelium. In contrast, the ciliary rootlet protein, Crocc, was located in discrete structures whose position was consistent with the dendritic knobs of the olfactory sensory neurons. A compilation of >2,000 mouse genes predicted to encode cilia-related proteins revealed a strong correlation ( R = 0.99) between the number of studies predicting a gene's involvement in cilia and documented evidence of such involvement, a fact that simplifies the selection of genes for further study of the physiology of cilia.
APA, Harvard, Vancouver, ISO, and other styles
9

Reed, C. J., E. A. Lock, and F. De Matteis. "NADPH: cytochrome P-450 reductase in olfactory epithelium Relevance to cytochrome P-450-dependent reactions." Biochemical Journal 240, no. 2 (December 1, 1986): 585–92. http://dx.doi.org/10.1042/bj2400585.

Full text
Abstract:
The presence of a very active cytochrome P-450-dependent drug-metabolizing system in the olfactory epithelium has been confirmed by using 7-ethoxycoumarin, 7-ethoxyresorufin, hexobarbitone and aniline as substrates, and the reasons for the marked activity of the cytochrome P-450 in this tissue have been investigated. The spectral interaction of hexobarbitone and aniline with hepatic and olfactory microsomes has been examined. By this criterion there was no evidence for marked differences in the spin state of the cytochromes of the two tissues, or for the olfactory epithelium containing a greater amount of cytochrome capable of binding hexobarbitone, a very actively metabolized substrate. Rates of NADPH and NADH: cytochrome c reductase activity were found to be higher in the olfactory epithelium than in the liver, and direct evidence was obtained for a greater amount of the NADPH-dependent flavoprotein in the olfactory microsomes. Investigation of male rats and male and female mice, as well as male hamsters, demonstrated that, in all cases, the cytochrome P-450 levels of the olfactory epithelium were lower than those of the liver, while the 7-ethoxycoumarin de-ethylase and NADPH:cytochrome c reductase activities were higher. A correlation was found between 7-ethoxycoumarin de-ethylase and NADPH:cytochrome c reductase activities for both tissues in all species examined. The ratio of reductase to cytochrome P-450 was found to be considerably higher in the olfactory epithelium (1:2-1:3) than in the liver (1:11-1:15), regardless of the species examined, suggesting that facilitated electron flow may contribute significantly to the cytochrome P-450 catalytic turnover in the olfactory tissue.
APA, Harvard, Vancouver, ISO, and other styles
10

Harrison, Paul J. H., Holly S. Cate, Pascal Steullet, and Charles D. Derby. "Structural plasticity in the olfactory system of adult spiny lobsters: postembryonic development permits life-long growth, turnover, and regeneration." Marine and Freshwater Research 52, no. 8 (2001): 1357. http://dx.doi.org/10.1071/mf01103.

Full text
Abstract:
Caribbean spiny lobsters (Panulirus argus) rely on their sense of olfaction for many behaviours. Growth of their olfactory systems, and maintenance of olfactory function, is ensured by structural change that occurs continuously throughout life. In this paper, we review recent studies on postembryonic development in the olfactory system of P. argus and several other decapod species. Major structural change occurs in both the peripheral and central olfactory systems; it includes addition and loss of olfactory receptor neurons (ORNs), aesthetasc and other sensilla, and interneurons associated with the olfactory lobes of the brain. From these studies it is clear that continuous growth and turnover of olfactory tissue is a normal process in decapod crustaceans. In addition, we describe for the first time mechanisms that enable the peripheral olfactory system of spiny lobsters to regenerate after injury. We monitored the regeneration of olfactory tissue usingin vivo incorporation of the cell proliferation marker 5- bromo-2′-deoxyuridine (BrdU). Our results show that regeneration after partial antennular amputation, which reduces the length of the antennule and thereby the number of ORNs, occurs as a result of upregulation of the normal mode of ORN addition and down-regulation of loss. In contrast, localized injury to aesthetasc sensilla, which causes the associated ORNs to degenerate but does not reduce antennular length, is followed by local regeneration of olfactory tissue.
APA, Harvard, Vancouver, ISO, and other styles
More sources

Dissertations / Theses on the topic "Olfactory tissue"

1

Lu, Jike Faculty of Medicine UNSW. "Transplantation of nasal olfactory tissues into transected spinal cord of adult rats." Awarded by:University of New South Wales, 2000. http://handle.unsw.edu.au/1959.4/17798.

Full text
Abstract:
Transplants of olfactory ensheathing cells (OECs) from olfactory bulbs have recently been shown to support regrowth and reinnervation of damaged spinal cord, which has led to improved functional recovery. Using complete transection in adult rat, the studies presented in this thesis examine the role of peripherally derived olfactory tissue in promoting axonal regeneration and functional recovery. Chapter One and Two provide the background to the area of spinal cord regeneration and the methods used in this thesis. Chapter Three shows that transplants of OECs from rat olfactory lamina propria (OLP) are able to support axon regrowth in the lesioned spinal cord. The BBB score was significantly higher in experimental rats (5.4???0.84) compared with control animals (1.9???0.33) (P<0.001). These dissociated OECs from OLP can promote axonal regrowth through the lesion. Histological assessment showed that: 1) axons labelled with Fluororuby grew into the injury site in OECs-transplanted rats, with occasional fibres extending into the rostral cord; 2) brainstem neurons in the raphe nucleus were retrogradely labeled with Fluororuby; and 3) serotonergic axons were detectable distal to the lesion in OECs-transplanted rats. No fibres grew into the injured region and no retrograde labeling or serotonergic fibres were seen in control animals. The role of regenerated serotonergic fibres in OECs-transplanted rats is discussed. Chapter Four demonstrates that solid pieces of OLP dissected from the nose can re-establish the continuity of the transected cord and supply the OECs that can migrate to the cord stumps to support the axon regeneration. Experimental rats which received OLP from olfactory mucosa showed significantly greater locomotive recovery (BBB scores: OLP, 5.0???1.9; control, 1.5???0.5, p<0.0001). In animals with OLP transplants, histological analysis indicated that nerve fibres, expressing neurofilament and serotonin were present at the transection site. Locomotive recovery of the hindlimbs occurred, similar to that seen after OECs transplantation. Retrograde labeling of medullary raphe neurons and gigantocellular reticular nucleus occurred following Fluororuby injection in the cord distal to the lesion, further supporting the supraspinal origin of the 5-HT innervation in the present studies. These results indicate that OLP is effective in promoting partial spinal cord repair. Chapter Five examines functional recovery of spinal reflex circuitry, ie., H-reflex excitability using paired stimuli, in OLP-transplanted rats compared with normal and respiratory lamina propria (RLP) transplanted animals. H-reflex amplitude of the conditioned response was significantly reduced in OLP transplanted rats compared to RLP transplanted animals (p< 0.05). Therefore, hindlimb reflex excitability can be modulated by OLP transplants after transection of the spinal cord in adult rats. Chapter Six examines whether functional recovery can occur if transplantation of OLP tissue is delayed by 1 month after the spinal cord transection. The BBB score was significantly higher in experimental rats (4.3???0.8 for OLP) compared with control animals (1.0???0.3, P< 0.001), but recovery was less than after acute transplantation. Asx before, histological assessment of OLP animals showed: a) serotonergic axons were present in the cord below the transection site; b) brainstem raphe nuclei was retrogradely labeled; c) bisbenzimide pre-labeled cells from OLP transplants migrated in host spinal cord. These changes were not seen in control animals. These results indicate that OLP has the ability to promote axonal regeneration in chronically injured cord of adult rats. Chapter Seven compares the results from these three types of intervention. In conclusion, these studies show that peripherally derived OECs or solid pieces of OLP can promote partial spinal cord repair in acute or chronic transection injuries. Such tissue might provide a potential source for autologous grafting in human paraplegia.
APA, Harvard, Vancouver, ISO, and other styles
2

Guo, Luzhi. "Ultrastructural characteristics of cultured embryonic mouse olfactory epithelial and bulb cells." Thesis, University of North Texas, 1991. https://digital.library.unt.edu/ark:/67531/metadc798462/.

Full text
Abstract:
This laboratory is involved in physiological and histochemical studies of olfactory tissue grown in cell culture in an attempt to create an in vitro model of the olfactory system. The present study is an in-depth ultrastructural study of the morphology of cultured olfactory cells to determine the extent of similarities and differences between cultured tissues and the intact olfactory system in vivo.
APA, Harvard, Vancouver, ISO, and other styles
3

Lee, Mary Elizabeth. "Axon growth and neuron-glia interactions in the olfactory system /." Thesis, Connect to this title online; UW restricted, 1997. http://hdl.handle.net/1773/5684.

Full text
APA, Harvard, Vancouver, ISO, and other styles
4

Franzen, Anna. "Tissue-selective activation and toxicity of substituted dichlorobenzenes : studies on the mechanism of cell death in the olfactory mucosa /." Uppsala : Acta Universitatis Upsaliensis: Univ.-bibl. [distributör], 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-6161.

Full text
APA, Harvard, Vancouver, ISO, and other styles
5

Franzén, Anna. "Tissue-Selective Activation and Toxicity of Substituted Dichlorobenzenes : Studies on the Mechanism of Cell Death in the Olfactory Mucosa." Doctoral thesis, Uppsala University, Department of Pharmaceutical Biosciences, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-6161.

Full text
Abstract:

The nasal passages are constantly exposed to both air- and bloodborne foreign compounds. In particular, the olfactory mucosa is demonstrated to be susceptible to a variety of drugs and chemicals. In this thesis, mechanisms involved in tissue-selective toxicity in the olfactory mucosa of rodents have been investigated using the olfactory toxicant 2,6-dichlorophenyl methylsulphone (2,6-diClPh-MeSO2) as a model compound. Comparative studies were performed with the non-toxic 2,5-dichlorophenyl methylsulphone (2,5-diClPh-MeSO2) and the reasons for the strikingly different toxicity were investigated.

A strong bioactivation and protein adduction of 2,6-diClPh-MeSO2 in olfactory microsomes and S9-fractions of rodents was demonstrated. In contrast, no significant metabolic activation of 2,5-diClPh-MeSO2 was observed and the bioactivation in the liver for both chlorinated isomers was negligible. In vitro studies with recombinant yeast cell microsomes expressing mouse cytochrome P450 2A5 (CYP2A5) demonstrated a metabolic activation of 2,6-diClPh-MeSO2. The 2,6-diClPh-MeSO2-induced lesions and CYP2A5 expression preferentially occurred in Bowman’s glands and sustentacular cells of the olfactory mucosa. A significant depletion of glutathione (GSH) in the olfactory mucosa was demonstrated in vivo, while no changes were observed in the liver. There was a rapid induction of the endoplasmic reticulum (ER)-specific chaperone Grp78, activation of the ER-specific caspase-12 and the downstream caspase-3 in the Bowman’s glands. Electron microscopy revealed swelling of ER and mitochondria and a lost integrity of the Bowman’s glands.

Based on these results, the proposed mechanism for 2,6-diClPh-MeSO2-induced toxicity in the olfactory mucosa is bioactivation by CYP2A5 into a reactive intermediate causing protein adduction and GSH-depletion. This is initiating a sequence of downstream events of ER-stress, changes in ion homeostasis, ultrastructural organelle disruption and apoptotic signalling. In spite of the initial apoptotic signals, the terminal phase of apoptosis seemed to be blocked and necrotic features occurred. The predominant expression of CYP2A5 in the olfactory mucosa is proposed to play a key role for the tissue- and cell-specific toxicity induced by 2,6-diClPh-MeSO2.

APA, Harvard, Vancouver, ISO, and other styles
6

Dittrich, Katarina [Verfasser], Ivan [Akademischer Betreuer] Manzini, Thomas [Gutachter] Dresbach, Kristine [Gutachter] Henningfeld, Ralf [Gutachter] Heinrich, Camin [Gutachter] Dean, and Michael [Gutachter] Hörner. "Olfactory neurogenesis during tissue maintenance and repair / Katarina Dittrich ; Gutachter: Thomas Dresbach, Kristine Henningfeld, Ralf Heinrich, Camin Dean, Michael Hörner ; Betreuer: Ivan Manzini." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2018. http://d-nb.info/1161183175/34.

Full text
APA, Harvard, Vancouver, ISO, and other styles
7

Cui, Tao. "Novel Circulating and Tissue Biomarkers for Small Intestine Neuroendocrine Tumors and Lung Carcinoids." Doctoral thesis, Uppsala universitet, Onkologisk endokrinologi, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-205570.

Full text
Abstract:
Small intestine neuroendocrine tumors (SI-NETs) and lung carcinoids (LCs) are relatively indolent tumors, which originate from neuroendocrine (NE) cells of the diffuse NE system. Metastases can spread before diagnosis. Thus, potential cures become unavailable, which entitles new biomarker development. Indeed, we aimed at developing Ma2 autoantibodies and olfactory receptor 51E1 (OR51E1) as potential novel biomarkers and exploring other candidate protein markers in patients’ serum. First, we established a sensitive, specific and reliable anti-Ma2 indirect ELISA to distinguish SI-NET patients from healthy controls. We detected longer progression-free and recurrence-free survivals in patients expressing low anti-Ma2 titers. Moreover, a high anti-Ma2 titer was more sensitive than chromogranin A for the risk of recurrence after radical operation of SI-NET patients. We then investigated OR51E1 expression in SI-NETs and LCs. OR51E1 mRNA expression, analyzed by quantitative real-time PCR, was high in microdissected SI-NET cells, in LC cell lines and in frozen LC specimens. Immunohistochemistry (IHC) showed abundant OR51E1 protein expression in SI-NETs. OR51E1 co-expressed with vesicular-monoamine-transporter-1 in the majority of normal and neoplastic enterochromaffin cells. Furthermore, the study on LCs revealed that OR51E1, somatostatin receptor (SSTR) 2, SSTR3, and SSTR5 are expressed in 85%, 71%, 25% and 39% of typical carcinoids (TCs), whereas in 86%, 79%, 43% and 36% of atypical carcinoids (ACs). Based on the proposed IHC scoring system, in the LC cases, where all SSTR subtypes were absent, membrane OR51E1 expression was detected in 10 out of 17 TCs and 1 out of 2 ACs. Moreover, higher OR51E1 scores were detected in 5 out of 6 OctreoScan-negative LC lesions. In addition, the last presented study used a novel suspension bead array, which targeted 124 unique proteins, by using Human Protein Atlas antibodies, to profile biotinylated serum samples from SI-NET patients and healthy controls. We showed 9 proteins, IGFBP2, IGF1, SHKBP1, ETS1, IL1α, STX2, MAML3, EGR3 and XIAP as significant contributors to tumor classification. In conclusion, we proposed Ma2 autoantibodies as a sensitive circulating marker for SI-NET recurrence; OR51E1 as a candidate therapeutic target for SI-NETs; whereas as a novel diagnostic marker for LCs and 9 serum proteins as novel potential SI-NET markers.
小肠神经内分泌肿瘤(SI-NET)和肺类癌(LC)是起源于不同神经内分泌细胞的生长缓慢的肿瘤。肿瘤往往于诊断前已经转移。这导致目前缺乏有效的治疗方法，同时也使得对于新的生物标记物的研发变得有意义。因此，我们在本论文中分别研究了Ma2自身抗体(抗Ma2)，以及潜在的新型生物标记物嗅觉受体51E1(OR51E1)。我们还探讨了患者血清中的其他候选蛋白标记物。 首先，我们建立了一个灵敏特异而可靠的抗Ma2间接酶联免疫吸附试验，用以区分SI-NET患者组和健康对照组。在表达低滴度抗Ma2的患者中，我们检测到了较长的病情无恶化存活率以及肿瘤无复发存活率。此外，高滴度抗Ma2比嗜铬粒蛋白A更为灵敏地检测到了SI-NET患者根治手术后复发的风险。     接下来，我们研究了SI-NET和LC患者肿瘤中的OR51E1受体蛋白的表达。我们用实时定量PCR技术检测到了OR51E1信使核糖核酸在显微切除的SI-NET肿瘤细胞中，以及在LC细胞系和冷冻LC标本中的高度表达。免疫组化结果显示出OR51E1蛋白在SI-NET肿瘤组织中的高度表达。OR51E1与囊泡单胺转运蛋白1在大多数正常和肿瘤的肠嗜铬细胞中可共表达。 另外，我们针对LC患者的研究显示，OR51E1受体蛋白以及促生长素抑制素受体(SSTR)2，SSTR3和SSTR5分别在85％，71％，25％和39％的典型性肺类癌(TC)，以及86％，79％，43％和36的非典型性肺类癌(AC)中表达。基于我们我提出的免疫组化结果得分系统，在无SSTR表达的LC中，OR51E1蛋白在17个TC中的10个以及2个AC中的1个中呈细胞膜表达。而且，在6个OctreoScan显象呈阴性的LC中，有5个OR51E1免疫组化得分很高。     此外，在本论文最后的一项研究中，我们采用了一种新型的悬浮磁珠阵列技术，通过使用来自于人类蛋白质图谱项目的针对124种独特蛋白质的抗体，对SI-NET患者和健康对照组的用生物素标记过的血清样本进行了分析。结果显示，通过利用9种蛋白，即IGFBP2，IGF1，SHKBP1，ETS1，STX2，IL1α，MAML3，EGR3和XIAP，我们可以显著的对肿瘤进行分类。     综上所述，我们提出Ma2自身抗体可作为一个体液中灵敏的生物标记物用以暗示SI-NET肿瘤的复发; OR51E1受体蛋白可作为一个在SI-NET治疗中所能用及的候选生物靶分子，并在LC中作为一种新型的潜在生物标记物。此外，我们在SI-NET患者血清中检测到了9种新的候选标记物蛋白。
APA, Harvard, Vancouver, ISO, and other styles
8

Ould-Yahoui, Adlane. "Le système MMP/TIMP dans la croissance neuritique et la motilité des cellules souches de la muqueuse olfactive." Thesis, Aix-Marseille 2, 2011. http://www.theses.fr/2011AIX20672.

Full text
Abstract:
Les métalloproteases matricielles (MMPs) appartiennent à une famille d'endopéptidases dépendantes du zinc, présentent sous forme secrétée ou membranaire (MT-MMP) et qui jouent un rôle fondamental dans la signalisation cellulaire. L'activité des MMPs est régulée par leur inhibiteurs endogènes, les inhibiteurs tissulaires des MMPs (TIMPs). Le système MMP/TIMP régule les interactions cellule-cellule et cellule-matrice extra cellulaire et module la motilité cellulaire par clivage protéolytique des composants de la matrice extra cellulaire aussi bien lors de processus physiologiques que dans des situations pathologiques.Dans un premier temps, nous avons mis en évidence le rôle de TIMP-1 dans la modulation de la croissance neuritique et la morphologie neuronale, via l'inhibition de MMP-2 et non de MMP-9. souches de la muqueuse olfactive (OE-MSCs). Nous montrons dans cette étude que les gélatinases MMP-2 et MMP-9 ainsi que la MMP membranaire MT1-MMP, sont impliquées dans la migration des OE-MSCs. Nous montrons également que les gélatinases sont probablement impliquées dans les propriétés neurotrophiques des OE-MSCs et des cellules engainantes olfactives.L'ensemble de ces résultats apporte de nouveaux éléments fondamentaux, dans la compréhension du rôle du système MMP/TIMP dans les processus post-lésionnels qui ont lieu au sein du système nerveux central
The matrix metalloproteinases (MMPs) belong to a growing family of Zn2+-dependent endopeptidases, secreted or membrane-bound (MT-MMP), which play a fundamental role in the cell signalling. The activity of the MMPs is regulated by their endogenous inhibitors, the tissue inhibitors of MMPs (TIMPs). The MMP / TIMP system regulates the cell-cell and cell-extracellular matrix interactions and modulates the cellular motility through the cleavage of protein components of the extracellular matrix, as well during physiological and pathological conditions.Our results suggest that TIMP-1 is implicated in the modulation of the neurite outgrowth and morphology of cortical neurons through the inhibition at least in part, of MMP-2 and not MMP-9. Afterward, we study of the system MMP / TIMP in the migration of the stem cells of olfactory ectomesenchymal stem cells (OE-MSCs). We show that gelatinases MMP-2 and MMP-9 as well as MT1-MMP, are involved in OE-MSCs migration. We also show that gelatinases are probably involved in neurotrophic properties of the OE-MSCs and olfactory ensheathing cells.Altogether, these results provide new evidences on the role of MMP/TIMP system in central nervous system post-lesional processes
APA, Harvard, Vancouver, ISO, and other styles
9

Dittrich, Katarina. "Olfactory neurogenesis during tissue maintenance and repair." Doctoral thesis, 2018. http://hdl.handle.net/11858/00-1735-0000-002E-E41A-B.

Full text
APA, Harvard, Vancouver, ISO, and other styles
10

Lu, Jike. "Transplantation of nasal olfactory tissues into transected spinal cord of adult rats /." 2000. http://www.library.unsw.edu.au/~thesis/adt-NUN/public/adt-NUN20010622.112434/index.html.

Full text
APA, Harvard, Vancouver, ISO, and other styles

Books on the topic "Olfactory tissue"

1

Skipper, Cathy, and Florian Birkmayer. The Role of Aromatherapy in the Treatment of Substance Use and Co-Occurring Disorders. Edited by Shahla J. Modir and George E. Muñoz. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190275334.003.0024.

Full text
Abstract:
Aromatherapy can be an important tool in the treatment of substance abuse and co-occurring disorders. When used by trained specialists, essential oils are safe, simple, and effective both in alleviating symptoms as well as helping increase self-awareness and transform consciousness. Olfaction is a powerful sensory modality, and olfactory receptors have been found in nearly every tissue of the body and parts of the Central Nervous System (CNS) relevant to addiction and motivation. Essential oils are widely used to support and alleviate nervous symptom disorders such as those triggered by addiction (i.e., anxiety, sleep problems, panic attacks, depression, stress etc.). The available scientific literature supports the traditional uses of the most common essential oils in this domain and is encouraging for the continued development of these powerful plants extracts for addiction support.
APA, Harvard, Vancouver, ISO, and other styles

Book chapters on the topic "Olfactory tissue"

1

Barber, Peter C., and Steen Jensen. "Olfactory Tissue Interactions Studied by Intraocular Transplantation." In Molecular Neurobiology of the Olfactory System, 333–52. Boston, MA: Springer US, 1988. http://dx.doi.org/10.1007/978-1-4613-0989-5_15.

Full text
APA, Harvard, Vancouver, ISO, and other styles
2

Chukhray, E. S., M. N. Veselova, O. M. Poltorack, V. V. Voznessenskaya, E. P. Zinkevich, and C. J. Wysocki. "Phosphatase Activity of Rat Olfactory and Vomeronasal Epithelial Tissue." In Chemical Signals in Vertebrates 6, 43–47. Boston, MA: Springer US, 1992. http://dx.doi.org/10.1007/978-1-4757-9655-1_8.

Full text
APA, Harvard, Vancouver, ISO, and other styles
3

Pisanelli, Anna Maria, and Krishna C. Persaud. "Whole Tissue Voltage Clamp of Frog Olfactory Mucosa Using a Modified Ussing Chamber." In Olfaction and Taste XI, 201–4. Tokyo: Springer Japan, 1994. http://dx.doi.org/10.1007/978-4-431-68355-1_80.

Full text
APA, Harvard, Vancouver, ISO, and other styles
4

Iloro, Ibon, Joaquín Fernández-Irigoyen, Iraide Escobes, Mikel Azkargorta, Enrique Santamaría, and Felix Elortza. "Methods for Human Olfactory Bulb Tissue Studies Using Peptide/Protein MALDI-TOF Imaging Mass Spectrometry (MALDI-IMS)." In Neuromethods, 91–106. New York, NY: Springer New York, 2017. http://dx.doi.org/10.1007/978-1-4939-7119-0_7.

Full text
APA, Harvard, Vancouver, ISO, and other styles
5

Striedter, Georg F., and R. Glenn Northcutt. "The Origin of Vertebrates." In Brains Through Time, 58–124. Oxford University Press, 2019. http://dx.doi.org/10.1093/oso/9780195125689.003.0002.

Full text
Abstract:
Some time in the Ediacaran or early Cambrian period, the first vertebrates emerged. Compared to the invertebrate chordates, early vertebrates were active predators, rather than suspension feeders. This change in behavior was facilitated by several major morphological innovations, including pharyngeal muscles that pump water through the pharynx, vascularized gills, paired image-forming eyes, a complex vestibular apparatus, lateral line receptors, taste buds, and a well-developed olfactory system. Early vertebrates also evolved several new brain regions, notably the telencephalon and the midbrain. Developmentally, most of these innovations were linked to the emergence of two novel embryonic tissues, namely placodes and neural crest. Although these tissues and their adult derivatives did not evolve “out of nothing,” they represent genuine innovations that contributed substantially to the evolutionary success of the vertebrate lineage.
APA, Harvard, Vancouver, ISO, and other styles
6

Koch, Christof. "Dendritic Spines." In Biophysics of Computation. Oxford University Press, 1998. http://dx.doi.org/10.1093/oso/9780195104912.003.0018.

Full text
Abstract:
Dendritic spines, sometimes also called dendritic thorns, are tiny, specialized protoplasmic protuberances that cover the surface of many neurons. First described by Ramón y Cajal (1909; 1991) in light-microscopic studies of Golgi stained tissue, they are among the most striking subneuronal features of many neurons. Indeed, the presence of a high density of dendritic spines allows the unambiguous classification of neuronal types into spiny and aspiny, sparsely spiny, or smooth neurons. Over 90% of all excitatory synapses that occur in the cortex are located on dendritic spines. Spines can be found in all vertebrates as well as in invertebrates (e.g., the dendrites of Kenyon cells in the mushroom bodies in the olfactory system of the insect brain). The intimate association of spines with synaptic traffic suggests some crucial role in synaptic transmission and plasticity. Because of their submicrometer size (see below), physiological hypotheses as to the function of dendritic spines have only very recently become accessible to the experimentalist. For the previous two decades, spine properties have been investigated through analytical and computational studies based on morphological data, providing a very fertile ground for the crosspollination of theory and experiment. (For a very readable historical account of this see Segev et al., 1995.) The recent technical advances in the direct visualization of calcium dynamics in dendrites and spines are now permitting direct tests of some of these theoretical inferences (Guthrie, Segal, and Kater, 1991; Müller and Connor, 1991; Yuste and Denk, 1995; Denk, Sugimori, and Llinás, 1995; Svoboda, Tank, and Denk, 1996). As discussed in this chapter and, more extensively, in Chap. 19, the theoretical models that have endowed spines with active properties giving rise to all-or-none behavior (Perkel and Perkel, 1985; Shepherd et al., 1985; Segev and Rail, 1988; Baer and Rinzel, 1991) have, in general, been confirmed experimentally. Historically, the possibility of implementing synaptic memory by modulating the electroanatomy of spines was recognized early on (Chang, 1952) and was subsequently analyzed in depth by Rail (1970, 1974, 1978) and many others. Because small changes in the spine morphology can lead to large changes in the amplitude of the EPSP induced by the excitatory synapse on the spine, spines have been considered to contribute to the modulation of synaptic “weight” during long-term potentiation (see Chap. 13).
APA, Harvard, Vancouver, ISO, and other styles

Conference papers on the topic "Olfactory tissue"

1

Liu, Qingjun, Weiwei Ye, Hui Yu, Ning Hu, Hua Cai, Ping Wang, Matteo Pardo, and Giorgio Sberveglieri. "Olfactory Mucosa Tissue Based Biosensor for Bioelectronic Nose." In OLFACTION AND ELECTRONIC NOSE: Proceedings of the 13th International Symposium on Olfaction and Electronic Nose. AIP, 2009. http://dx.doi.org/10.1063/1.3156500.

Full text
APA, Harvard, Vancouver, ISO, and other styles
You might also be interested in the extended bibliographies on the topic 'Olfactory tissue' for particular source types:
Journal articles
We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!

To the bibliography