Log in

Relevant bibliographies by topics / Olfactory nerve – Regeneration

Academic literature on the topic 'Olfactory nerve – Regeneration'

Author: Grafiati

Published: 4 June 2021

Last updated: 19 February 2022

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Contents

Journal articles
Dissertations / Theses
Books
Book chapters

Consult the lists of relevant articles, books, theses, conference reports, and other scholarly sources on the topic 'Olfactory nerve – Regeneration.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Journal articles on the topic "Olfactory nerve – Regeneration"

1

Jiang, Rong-San, and Yu-Yu Lu. "Functional Olfactory Nerve Regeneration Demonstrated by Thallium-201 Olfacto-Scintigraphy in Patients with Traumatic Anosmia: A Case Report." Case Reports in Otolaryngology 2019 (November 16, 2019): 1–7. http://dx.doi.org/10.1155/2019/1069741.

Full text

Abstract:

Head trauma is one of the most common etiologies of olfactory dysfunction. It is difficult to use either the olfactory function test or magnetic resonance imaging to directly assess the course of damage to olfactory nerves. Thallium-201 (201Tl) olfacto-scintigraphy has been shown to be an able means for objectively assessing the olfactory nerve transport function. It is expected to be used to evaluate olfactory nerve regeneration after damage to the olfactory nerves. However, no such result has been reported. We present a patient who lost his olfactory function after experiencing head trauma. When his olfactory function remained anosmic, a 201Tl olfacto-scintigraphy showed no migration of 201Tl from the nasal mucosa to the olfactory bulb. After treatment with medicines and olfactory training, his olfactory function improved. A second 201Tl olfacto-scintigraphy showed an increased migration of 201Tl from the nasal mucosa to the olfactory bulb.

APA, Harvard, Vancouver, ISO, and other styles

2

Li, Manyi, Qiubei Zhu, and Jisheng Liu. "Olfactory ensheathing cells in facial nerve regeneration." Brazilian Journal of Otorhinolaryngology 86, no. 5 (September 2020): 525–33. http://dx.doi.org/10.1016/j.bjorl.2018.07.006.

Full text

APA, Harvard, Vancouver, ISO, and other styles

3

Alvites, Rui D., Mariana V. Branquinho, Ana C. Sousa, Irina Amorim, Rui Magalhães, Filipa João, Diogo Almeida, et al. "Combined Use of Chitosan and Olfactory Mucosa Mesenchymal Stem/Stromal Cells to Promote Peripheral Nerve Regeneration In Vivo." Stem Cells International 2021 (January 2, 2021): 1–32. http://dx.doi.org/10.1155/2021/6613029.

Full text

Abstract:

Peripheral nerve injury remains a clinical challenge with severe physiological and functional consequences. Despite the existence of multiple possible therapeutic approaches, until now, there is no consensus regarding the advantages of each option or the best methodology in promoting nerve regeneration. Regenerative medicine is a promise to overcome this medical limitation, and in this work, chitosan nerve guide conduits and olfactory mucosa mesenchymal stem/stromal cells were applied in different therapeutic combinations to promote regeneration in sciatic nerves after neurotmesis injury. Over 20 weeks, the intervened animals were subjected to a regular functional assessment (determination of motor performance, nociception, and sciatic indexes), and after this period, they were evaluated kinematically and the sciatic nerves and cranial tibial muscles were evaluated stereologically and histomorphometrically, respectively. The results obtained allowed confirming the beneficial effects of using these therapeutic approaches. The use of chitosan NGCs and cells resulted in better motor performance, better sciatic indexes, and lower gait dysfunction after 20 weeks. The use of only NGGs demonstrated better nociceptive recoveries. The stereological evaluation of the sciatic nerve revealed identical values in the different parameters for all therapeutic groups. In the muscle histomorphometric evaluation, the groups treated with NGCs and cells showed results close to those of the group that received traditional sutures, the one with the best final values. The therapeutic combinations studied show promising outcomes and should be the target of new future works to overcome some irregularities found in the results and establish the combination of nerve guidance conduits and olfactory mucosa mesenchymal stem/stromal cells as viable options in the treatment of peripheral nerves after injury.

APA, Harvard, Vancouver, ISO, and other styles

4

Verdú, Enrique, Xavier Navarro, Graciela Gudiño-Cabrera, Francisco J. Rodríguez, Dolores Ceballos, Antoni Valero, and Manuel Nieto-Sampedro. "Olfactory bulb ensheathing cells enhance peripheral nerve regeneration." NeuroReport 10, no. 5 (April 1999): 1097–101. http://dx.doi.org/10.1097/00001756-199904060-00035.

Full text

APA, Harvard, Vancouver, ISO, and other styles

5

Nathan, Britto P., Rafia Nisar, Jody Short, Shari Randall, Elin Grissom, Gwen Griffin, Paul V. Switzer, and Robert G. Struble. "Delayed olfactory nerve regeneration in ApoE-deficient mice." Brain Research 1041, no. 1 (April 2005): 87–94. http://dx.doi.org/10.1016/j.brainres.2005.02.011.

Full text

APA, Harvard, Vancouver, ISO, and other styles

6

Yamada, Kentaro, Hideaki Shiga, Takuya Noda, Masayuki Harita, Tomoko Ishikura, Yukari Nakamura, Toshihisa Hatta, Hiromi Sakata-Haga, Hiroki Shimada, and Takaki Miwa. "The Impact of Ovariectomy on Olfactory Neuron Regeneration in Mice." Chemical Senses 45, no. 3 (February 3, 2020): 203–9. http://dx.doi.org/10.1093/chemse/bjaa005.

Full text

Abstract:

Abstract Estrogen has been shown to affect differentiation and proliferation as a mitogen in various neural systems. Olfactory receptor cells are unique within the nervous system, and have the ability to regenerate even after an individual has reached maturity. Olfactory receptor cells also regenerate after experimentally induced degeneration. The purpose of this study is to observe the influence of estrogen depletion induced by ovariectomy on olfactory nerve regeneration. Female mice underwent bilateral ovariectomy at 8 weeks of age and received intraperitoneal administration of methimazole 1 week later. At 2, 4, and 6 weeks after methimazole administration, the olfactory mucosa was analyzed histochemically to determine olfactory epithelium (OE) thickness, olfactory marker protein distribution, and Ki-67 immunoreactivity. Furthermore, 2 weeks after ovariectomy, trkA protein distribution in the OE and nerve growth factor (NGF) levels in the olfactory bulb were determined by immunohistochemistry and enzyme-linked immunosorbent assay, respectively. Our results showed that in ovariectomized mice OMP, Ki-67, and trkA-immunopositive cells expression decreased at 2 weeks after methimazole injection, a time point at which regeneration is underway. At this same time point, although NGF production in the olfactory bulb had increased before methimazole administration, no differences were observed between the ovx and control groups. These results suggest that estrogen depletion induces a suppressive effect on regeneration of olfactory neurons, and that estrogen may have a potential use in the treatment of sensorineural olfactory dysfunction.

APA, Harvard, Vancouver, ISO, and other styles

7

Radtke, Christine, Masanori Sasaki, Karen L. Lankford, Vittorio Gallo, and Jeffery D. Kocsis. "CNPase Expression in Olfactory Ensheathing Cells." Journal of Biomedicine and Biotechnology 2011 (2011): 1–8. http://dx.doi.org/10.1155/2011/608496.

Full text

Abstract:

A large body of work supports the proposal that transplantation of olfactory ensheathing cells (OECs) into nerve or spinal cord injuries can promote axonal regeneration and remyelination. Yet, some investigators have questioned whether the transplanted OECs associate with axons and form peripheral myelin, or if they recruit endogenous Schwann cells that form myelin. Olfactory bulbs from transgenic mice expressing the enhanced green fluorescent protein (eGFP) under the control of the 2-3-cyclic nucleotide 3-phosphodiesterase (CNPase) promoter were studied. CNPase is expressed in myelin-forming cells throughout their lineage. We examined CNPase expression in both in situ in the olfactory bulb andin vitroto determine if OECs express CNPase commensurate with their myelination potential. eGFP was observed in the outer nerve layer of the olfactory bulb. Dissociated OECs maintained in culture had both intense eGFP expression and CNPase immunostaining. Transplantation of OECs into transected peripheral nerve longitudinally associated with the regenerated axons. These data indicate that OECs in the outer nerve layer of the olfactory bulb of CNPase transgenic mice express CNPase. Thus, while OECs do not normally form myelin on olfactory nerve axons, their expression of CNPase is commensurate with their potential to form myelin when transplanted into injured peripheral nerve.

APA, Harvard, Vancouver, ISO, and other styles

8

Zippel, Hans Peter. "In goldfish the discriminative ability for odours persists after reduction of the olfactory epithelium, and rapidly returns after olfactory nerve axotomy and crossing bulbs." Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences 355, no. 1401 (September 29, 2000): 1219–23. http://dx.doi.org/10.1098/rstb.2000.0671.

Full text

Abstract:

Goldfish are ideal vertebrates for the study of regeneration within the peripheral and the central olfactory system. The present behavioural investigations studied the effects of bilateral lesions on the animals' ability to qualitatively discriminate two amino acids (107 -6 M) and their performance in two more difficult tasks: (i) rewarded amino acid applied in a lower concentration, and (ii) rewarded stimulus contaminated. A 50 and 85% reduction of the olfactory epithelium resulted in no recordable behavioural deficit. After axotomy of olfactory nerves and lateral olfactory tractotomy, fishes were anosmic for seven to ten days. Following replacement of sensory cells in the epithelium, and after regeneration of olfactory tract fibres a full functional recovery, i.e. a highly specific regeneration, was recorded. After three surgical modifications of the olfactory bulbs' position, (i) crossing olfactory tracts and bulbs, (ii) crossing tracts and turning bulbs, and (iii) turning bulbs upside down, a full functional recovery was recorded for amino-acid discrimination in a similar concentration. A permanent, and similar slight deficit was, however, found during application of different concentrations, and of contaminated stimuli when medial lateral halves of the bulb were in ‘incorrect’ position (i) and (iii), or olfactory bulbs were positioned in the vicinity of the contralateral epithelium (i) and (ii).

APA, Harvard, Vancouver, ISO, and other styles

9

Deng, Yue, Jing-Ping Fan, Jian Gu, He Xu, Ya-Ping Xu, Huan-Hai Liu, Jun-Tian Lang, Xiao-Ping Chen, and Wei-Hua Xu. "Olfactory ensheathing cells promote nerve regeneration and functional recovery after facial nerve defects." Neural Regeneration Research 14, no. 1 (2019): 124. http://dx.doi.org/10.4103/1673-5374.243717.

Full text

APA, Harvard, Vancouver, ISO, and other styles

10

Radtke, Christine, Ayal A. Aizer, Samuel K. Agulian, Karen L. Lankford, Peter M. Vogt, and Jeffery D. Kocsis. "Transplantation of olfactory ensheathing cells enhances peripheral nerve regeneration after microsurgical nerve repair." Brain Research 1254 (February 2009): 10–17. http://dx.doi.org/10.1016/j.brainres.2008.11.036.

Full text

APA, Harvard, Vancouver, ISO, and other styles

More sources

Dissertations / Theses on the topic "Olfactory nerve – Regeneration"

1

Mallek, Jennifer de Toledo. "Hyaluronic acid-olfactory ensheathing cell compositions for spinal cord injury nerve regeneration." [Gainesville, Fla.] : University of Florida, 2006. http://purl.fcla.edu/fcla/etd/UFE0015880.

Full text

APA, Harvard, Vancouver, ISO, and other styles

2

Lee, I.-Hui. "On CNS injury and olfactory ensheathing cell engraftment strategies /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-551-8/.

Full text

APA, Harvard, Vancouver, ISO, and other styles

3

Dombrowski, Mary A. "Sciatic nerve remyelination and nodal formation following olfactory ensheathing cell transplantation." Yale University, 2008. http://ymtdl.med.yale.edu/theses/available/etd-08092007-114648/.

Full text

Abstract:

Transplantation of olfactory ensheathing cells (OECs) into injured spinal cord results in improved functional outcome through axonal regeneration, remyelination, and neuroprotection. However, because little is known of the fate of OECs transplanted into injured peripheral nerve, their myelin forming potential requires investigation. To study these issues OECs were isolated from the olfactory bulbs of adult green fluorescent protein (GFP)-expressing transgenic rats and transplanted into a sciatic nerve crush lesions. Five weeks to six months after transplantation the nerves were studied histologically and it was determined that GFP-expressing OECs survived in the lesion and distributed longitudinally across the lesion zone. Immunostaining revealed a high density of isoform Nav1.6 at the newly formed nodes of Ranvier which were flanked by paranodal Caspr staining. Immuno-electron microscopy for GFP revealed transplanted OECs form peripheral type myelin. These results indicate that transplanted OECs extensively integrate into transected peripheral nerve, form myelin on regenerated peripheral nerve fibers, and reconstruct nodes of Ranvier with proper sodium channel structure.

APA, Harvard, Vancouver, ISO, and other styles

4

Vukovic, Jana. "An in vitro and in vitro study on the role of the glycoprotein fibulin-3 in olfactory nerve growth and repair." University of Western Australia. School of Anatomy and Human Biology, 2008. http://theses.library.uwa.edu.au/adt-WU2008.0182.

Full text

Abstract:

The primary olfactory pathway in adult mammals has retained a remarkable potential for self-repair. Olfactory ensheathing cells (OECs), specialized glial cells within the olfactory nerve, are thought to play an important role in the ongoing growth and replenishment of sensory connections in this system. To gain insight into novel molecules that could mediate OEC-supported growth of axons within the olfactory nerve, gene expression profiling experiments revealed very high expression of the fibulin-3 glycoprotein in OECs. To date, research on fibulin-3 has been limited and mainly focused on its involvement in Doyne honeycomb retinal dystrophy, vasculogenesis and tumor formation. As the extracellular matrix associated with OECs is thought to be an important contributor to a growth-permissive environment, the main aim of this thesis was to define a putative role for fibulin-3 during olfactory receptor neuron replacement and regeneration. This hypothesis was investigated in a series of in vitro and in vivo experiments that involved lentiviral vectors to manipulate fibulin-3 gene expression in OECs as well as the use of knock-out mice. Using genetically-modified OECs, experimental data showed that increased levels of fibulin-3 induced morphological changes in OECs and also impeded their migration. Lentiviral vector-mediated expression of fibulin-3 in OECs also had an inhibitory effect on neurite outgrowth from dorsal root ganglion explants. On the other hand, knock-down of fibulin-3 levels via siRNA technology resulted in reduced proliferation. Comparative lesioning experiments in fibulin-3 knock-out and wild-type mice allowed for further assessment of a role for fibulin-3 in olfactory nerve repair in vivo. Two experimental injury models, i.e. epithelial (Triton-X) lesioning and olfactory bulbectomy, were employed. The results obtained were in line with in vitro observations. A lack of fibulin-3 in knock-out mice resulted in a seemingly augmented regeneration of the olfactory epithelium at 10 days post-injury. However, at the latest recovery time point of 42 days post-injury, an impaired recovery of the olfactory epithelium from the experimental insults was observed. Although the precise mechanism for the latter phenomenon is not yet fully understood, our data point towards several factors which include vascular abnormalities and altered cell proliferation within the olfactory epithelium. Additionally, the precise protein distribution of another wide-spread family of extracellular matrix molecules, the laminins, was investigated in this thesis. It was of interest to investigate the spatiotemporal expression of laminin isoforms during iii olfactory nerve development and regeneration as these molecules may have distinct roles in promoting olfactory sensory neuron growth and patterning. In situ hybridization and immunohistochemical studies concluded that laminin-211 and laminin-411 were the most likely candidates to play such a role. In summary, this thesis provides new insights into the role of the extracellular matrix, fibulin-3 in particular, in regulating cell migration, division and axonal growth in the primary olfactory pathway. Such knowledge also gives a greater understanding of the molecular mechanisms by which OEC transplants may enhance axonal regeneration elsewhere in the CNS.

APA, Harvard, Vancouver, ISO, and other styles

5

Bakos, Stephen. "The Expression of Matrix Metalloproteinase-9 and -2 in Olfactory Injury and Recovery." VCU Scholars Compass, 2010. http://scholarscompass.vcu.edu/etd/143.

Full text

Abstract:

The olfactory system has the remarkable capacity for neurogenesis following injury. However, the molecular mechanisms important for reinnervation of the olfactory bulb (OB) remain unknown. The matrix metalloproteinases (MMPs) are important components in many central nervous system (CNS) injury paradigms, yet remain unexplored in olfactory injury and recovery. To address the role of MMPs, the temporal expressions of MMP-9 and MMP-2 were examined in 3 olfactory injury models: nerve transection (NTx), methyl bromide gas (MeBr) exposure, and nerve transection with Teflon barrier (NTx-TB). Each injury model represents a different degree of olfactory injury and neuronal recovery. In NTx, sensory axons are lesioned, leading to neuronal degeneration and subsequent reinnervation of the OB. MeBr exposure damages the cell bodies of sensory neurons in the peripheral olfactory epithelium (OE), leading to degeneration and reinnervation of the OB without direct trauma to the OB. In NTx-TB, sensory axons are lesioned and a barrier is inserted following injury that blocks regenerated neurons from reinnervation of the OB. Following NTx, MMP-9 increased immediately in the OB and was localized to neutrophils, an inflammatory leukocyte. The elevated levels of MMP-9 corresponded to neuronal degeneration. To confirm this relationship, MMP-9 expression was measured following MeBr injury. MMP-9 increased during neuronal degeneration in the OB and was localized to neutrophils in the area of sensory axon degradation. These experiments demonstrated that MMP-9 is important for both neuronal degeneration and the acute inflammatory response following olfactory injury. In NTx injury, MMP-2 expression peaked at day 7 and corresponded to the transition between degeneration and reinnervation of the OB. MMP-2 was localized to the granule cell and external plexiform layers in control and day 7 bulbs. Following NTx-TB, MMP-2 remained low and was not expressed by regenerated axons. The absence of a MMP-2 peak in the NTx-TB injury suggests that this peak depends on reinnervation of the OB. This study demonstrates a temporal correlation between MMP-9 and degeneration and MMP-2 and reinnervation following olfactory injury. These findings provide new insight into the molecular mechanisms underlying olfactory nerve injury. Modulation of MMPs could provide novel therapeutic interventions to improve neuronal recovery following injury.

APA, Harvard, Vancouver, ISO, and other styles

6

Alvites, Rui Damazio. "Combined use of Olfactory Mucosa Mesenchymal Stem Cells and Biomaterials in Regenerative Therapies after Peripheral Nerve Injury." Tese, 2021. https://hdl.handle.net/10216/134928.

Full text

APA, Harvard, Vancouver, ISO, and other styles

7

Alvites, Rui Damazio. "Combined use of Olfactory Mucosa Mesenchymal Stem Cells and Biomaterials in Regenerative Therapies after Peripheral Nerve Injury." Doctoral thesis, 2021. https://hdl.handle.net/10216/134928.

Full text

APA, Harvard, Vancouver, ISO, and other styles

Books on the topic "Olfactory nerve – Regeneration"

1

Galbraith, David Allen. A study of the regeneration of olfactory neuron populations in Rana pipiens. [New Haven: s.n.], 1988.

Find full text

APA, Harvard, Vancouver, ISO, and other styles

Book chapters on the topic "Olfactory nerve – Regeneration"

1

Radtke, Christine, Jeffery D. Kocsis, and Peter M. Vogt. "Chapter 22 Transplantation of Olfactory Ensheathing Cells for Peripheral Nerve Regeneration." In International Review of Neurobiology, 405–15. Elsevier, 2009. http://dx.doi.org/10.1016/s0074-7742(09)87022-0.

Full text

APA, Harvard, Vancouver, ISO, and other styles

2

Alvites, Rui Damásio, Ana Rita Caseiro Santos, Artur Severo Proença Varejão, and Ana C. P. d. C. O. Maurício. "Olfactory Mucosa Mesenchymal Stem Cells and Biomaterials: A New Combination to Regenerative Therapies after Peripheral Nerve Injury." In Mesenchymal Stem Cells - Isolation, Characterization and Applications. InTech, 2017. http://dx.doi.org/10.5772/intechopen.68174.

Full text

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!