Academic literature on the topic 'Oleocanthal'

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Journal articles on the topic "Oleocanthal"

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Barbalace, Maria Cristina, Michela Freschi, Irene Rinaldi, et al. "Unraveling the Protective Role of Oleocanthal and Its Oxidation Product, Oleocanthalic Acid, against Neuroinflammation." Antioxidants 13, no. 9 (2024): 1074. http://dx.doi.org/10.3390/antiox13091074.

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Neuroinflammation is a critical aspect of various neurodegenerative diseases, such as Alzheimer’s and Parkinson’s diseases. This study investigates the anti-neuroinflammatory properties of oleocanthal and its oxidation product, oleocanthalic acid, using the BV-2 cell line activated with lipopolysaccharide. Our findings revealed that oleocanthal significantly inhibited the production of pro-inflammatory cytokines and reduced the expression of inflammatory genes, counteracted oxidative stress induced by lipopolysaccharide, and increased cell phagocytic activity. Conversely, oleocanthalic acid wa
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Esposito Salsano, Jasmine, Maria Digiacomo, Doretta Cuffaro, Simone Bertini, and Marco Macchia. "Content Variations in Oleocanthalic Acid and Other Phenolic Compounds in Extra-Virgin Olive Oil during Storage." Foods 11, no. 9 (2022): 1354. http://dx.doi.org/10.3390/foods11091354.

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The health benefits of extra-virgin olive oil (EVOO) are strictly linked to the presence of phenolic compounds, which exhibit numerous nutraceutical properties. In EVOO, the most important class of phenolic compounds is represented by secoiridoids (oleacein and oleocanthal). EVOO is constantly subjected to degradation processes, including hydrolytic and oxidative reactions that influence its phenolic composition. In particular, the hydrolytic reactions determine the transformation of oleocanthal and oleacein into the corresponding phenyl-alcohols, tyrosol, and hydroxytyrosol. Furthermore, oleo
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Liu, Xiuye, Lijuan Yang, Li Wang, and Qiongmei Guo. "Oleocanthal protects against neuronal inflammation and cardiopulmonary bypass surgery-induced brain injury in rats by regulating the NLRP3 pathway." Restorative Neurology and Neuroscience 39, no. 1 (2021): 39–44. http://dx.doi.org/10.3233/rnn-201073.

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Background: Open heart surgery is performed with the aid of cardiopulmonary bypass (CPB) techniques that may cause neuronal injuries. Objective: This study investigated the potential protective effect of oleocanthal pre-treatment against CPB-induced cerebral injury. Methods: Oleocanthal 30 mg/kg i.p. was administered 3 h before CPB induction in the treated group. Behavioral neurological scores and cerebral injury were assessed to determine the effects of oleocanthal, based on oxidative stress and serum mediators of inflammation by enzyme-linked immunosorbent assay (ELISA). Quantitative Polymer
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Muhammad Addien Prima Nanda and Muhammad Reagen. "Chondroprotective Potential of Oleocanthal and Hydroxytyrosol from Extra Virgin Olive Oil: A Meta-Analysis." Bioscientia Medicina : Journal of Biomedicine and Translational Research 9, no. 5 (2025): 7324–37. https://doi.org/10.37275/bsm.v9i5.1276.

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Background: Osteoarthritis (OA) is a prevalent degenerative joint disease characterized by cartilage degradation, inflammation, and pain. Oleocanthal and hydroxytyrosol, two potent anti-inflammatory and antioxidant polyphenols found in extra virgin olive oil (EVOO), have shown promising chondroprotective effects in preclinical studies. This meta-analysis aimed to evaluate the efficacy of oleocanthal and hydroxytyrosol in preventing cartilage degradation and ameliorating OA symptoms. Methods: A systematic search of electronic databases (PubMed, Scopus, and Web of Science) was conducted to ident
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Katsa, Maria Efthymia, Kleopatra Ketselidi, Marianna Kalliostra, et al. "Acute Antiplatelet Effects of an Oleocanthal-Rich Olive Oil in Type II Diabetic Patients: A Postprandial Study." International Journal of Molecular Sciences 25, no. 2 (2024): 908. http://dx.doi.org/10.3390/ijms25020908.

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Postprandial dysmetabolism is a common entity of type 2 diabetes mellitus (T2DM) and may act as a daily stressor of the already dysfunctional diabetic platelets. This study aims to investigate whether oleocanthal-rich olive oils (OO), incorporated into a carbohydrate-rich meal, can affect postprandial dysmetabolism and platelet aggregation. Oleocanthal is a cyclooxygenase inhibitor with putative antiplatelet properties. In this randomized, single-blinded, crossover study, ten T2DM patients consumed five isocaloric meals containing 120 g white bread combined with: (i) 39 g butter, (ii) 39 g but
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Giusti, Laura, Cristina Angeloni, Maria Barbalace, et al. "A Proteomic Approach to Uncover Neuroprotective Mechanisms of Oleocanthal against Oxidative Stress." International Journal of Molecular Sciences 19, no. 8 (2018): 2329. http://dx.doi.org/10.3390/ijms19082329.

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Neurodegenerative diseases represent a heterogeneous group of disorders that share common features like abnormal protein aggregation, perturbed Ca2+ homeostasis, excitotoxicity, impairment of mitochondrial functions, apoptosis, inflammation, and oxidative stress. Despite recent advances in the research of biomarkers, early diagnosis, and pharmacotherapy, there are no treatments that can halt the progression of these age-associated neurodegenerative diseases. Numerous epidemiological studies indicate that long-term intake of a Mediterranean diet, characterized by a high consumption of extra vir
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Cassiano, Chiara, Agostino Casapullo, Alessandra Tosco, Maria Chiara Monti, and Raffaele Riccio. "In Cell Interactome of Oleocanthal, an Extra Virgin Olive Oil Bioactive Component." Natural Product Communications 10, no. 6 (2015): 1934578X1501000. http://dx.doi.org/10.1177/1934578x1501000654.

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A copper-(I)-catalyzed variation of the Huisgen 1,3-dipolar cycloaddition has been applied to lead the in living-cell mass-spectrometry based identification of protein targets of oleocanthal, a natural metabolite daily ingested by millions of people. Chemical proteomics revealed heat-shock proteins, HSP70 and HSP90, as main oleocanthal interactors in living systems. These two proteins are involved in cancer development and, thus, our findings could have important outcomes for a deep evaluation of the bio-pharmacological significance of oleocanthal.
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Papakonstantinou, Aikaterini, Petrina Koumarianou, Aimilia Rigakou, et al. "New Affordable Methods for Large-Scale Isolation of Major Olive Secoiridoids and Systematic Comparative Study of Their Antiproliferative/Cytotoxic Effect on Multiple Cancer Cell Lines of Different Cancer Origins." International Journal of Molecular Sciences 24, no. 1 (2022): 3. http://dx.doi.org/10.3390/ijms24010003.

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Olive oil phenols (OOPs) are associated with the prevention of many human cancers. Some of these have been shown to inhibit cell proliferation and induce apoptosis. However, no systematic comparative study exists for all the investigated compounds under the same conditions, due to difficulties in their isolation or synthesis. Herein are presented innovative methods for large-scale selective extraction of six major secoiridoids from olive oil or leaves enabling their detailed investigation. The cytotoxic/antiproliferative bioactivity of these six compounds was evaluated on sixteen human cancer
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Di Pietro, Marisa, Simone Filardo, Roberto Mattioli, et al. "Anti-Biofilm Activity of Oleacein and Oleocanthal from Extra-Virgin Olive Oil toward Pseudomonas aeruginosa." International Journal of Molecular Sciences 25, no. 9 (2024): 5051. http://dx.doi.org/10.3390/ijms25095051.

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New antimicrobial molecules effective against Pseudomonas aeruginosa, known as an antibiotic-resistant “high-priority pathogen”, are urgently required because of its ability to develop biofilms related to healthcare-acquired infections. In this study, for the first time, the anti-biofilm and anti-virulence activities of a polyphenolic extract of extra-virgin olive oil as well as purified oleocanthal and oleacein, toward P. aeruginosa clinical isolates were investigated. The main result of our study was the anti-virulence activity of the mixture of oleacein and oleocanthal toward multidrug-resi
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Goren, Limor, George Zhang, Susmita Kaushik, Paul A. S. Breslin, Yi-Chieh Nancy Du, and David A. Foster. "(-)-Oleocanthal and (-)-oleocanthal-rich olive oils induce lysosomal membrane permeabilization in cancer cells." PLOS ONE 14, no. 8 (2019): e0216024. http://dx.doi.org/10.1371/journal.pone.0216024.

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Dissertations / Theses on the topic "Oleocanthal"

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Esposito, Salsano Jasmine. "Nutraceutical properties of extra-virgin olive oils and leaves extracts from autochthonous tuscan olive trees." Doctoral thesis, Università di Siena, 2022. http://hdl.handle.net/11365/1190965.

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L’olio extravergine d’oliva (Extra-Virgin Olive Oil, EVOO) e l’estratto di foglie d’ulivo (Olive Leaves Extract, OLE) rappresentano un'importante fonte di composti nutraceutici, tra cui si annoverano composti a struttura fenolica e polifenolica come i fenil alcoli, gli acidi fenolici, i lignani, i flavoni, i flavonoli ed i secoiridoidi, una classe di composti esclusivi della famiglia delle Oleaceae. I secoiridoidi principalmente presenti nell’EVOO sono l’oleaceina e l’oleocantale, mentre nelle foglie si ritrova l’oleuropeina. Questi composti possiedono proprietà nutraceutiche, quali quelle ant
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Serena, Lacerenza. "Proteomics as a tool to investigate ROS-related pathologies: new putative biomarkers for malignant pleural mesothelioma and neuroprotective mechanisms of oleocanthal in neurodegenerative diseases." Doctoral thesis, Università di Siena, 2019. http://hdl.handle.net/11365/1073196.

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Oxidative stress contributes to the development and progression of a broad range of syndromes and diseases, especially cancer and neurodegenerative processes. Malignant pleural mesothelioma (MPM) is a highly aggressive tumor originating from the mesothelial cells of the pleura, associated with asbestos exposure. Inhalation of long and thin asbestos fibers induces a chronic inflammatory response at sites of fibers deposition, with accumulation of reactive oxygen species (ROS) and reactive nitrogen species (RNS) that over time may lead to malignant cell transformation. MPM is characterized by a
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Ribeiro, Ana Sofia Salgueiro Costa da Costa. "Contributo para a caracterização de azeite virgem extra de qualidade superior na região Alentejo." Master's thesis, 2018. http://hdl.handle.net/10362/84552.

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O azeite é um dos principais componentes da dieta mediterrânica. A caracterização de azeites monovarietais permite identificar a singularidade das características de cada cultivar que lhe conferem propriedades únicas e valorizáveis, permitindo acrescentar valor ao azeite. Como tal, pretendeu-se com este estudo contribuir para o conhecimento da composição química de azeites monovarietais provenientes da região do Alentejo. Foram selecionadas sete variedades de azeitona Arbequina, Blanqueta, Cobrançosa, Cordovil, Galega, Picual e Verdeal de Serpa, por serem atualmente as que melhor representam
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Book chapters on the topic "Oleocanthal"

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Domínguez-López, Inés, Maria Pérez, Anallely López-Yerena, et al. "Chapter 9. Human Health and the Consumption of Fat-associated Compounds: Tyrosol, Hydroxytyrosol, Oleuropein, Oleacein, and Oleocanthal." In Food Chemistry, Function and Analysis. Royal Society of Chemistry, 2021. http://dx.doi.org/10.1039/9781839165078-00216.

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Brahmachari, Goutam. "Oleocanthal." In Total Synthesis of Bioactive Natural Products. Elsevier, 2019. http://dx.doi.org/10.1016/b978-0-08-102822-3.00044-4.

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Batarseh, Yazan S., Sweilem B. Al Rihani, Euitaek Yang, and Amal Kaddoumi. "Neuroprotective effects of oleocanthal in neurological disorders." In Olives and Olive Oil in Health and Disease Prevention. Elsevier, 2021. http://dx.doi.org/10.1016/b978-0-12-819528-4.00055-9.

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Ayoub, Nehad M. "Olive oil oleocanthal and estrogen receptor expression." In Olives and Olive Oil in Health and Disease Prevention. Elsevier, 2021. http://dx.doi.org/10.1016/b978-0-12-819528-4.00053-5.

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Üçüncüoğlu, Didar. "Olive Phenomenon from the Mediterranean Diet: Health Promotion Via Phytochemicals." In Olive Oil - New Perspectives and Applications [Working Title]. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.96938.

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The Mediterranean Diet contains fruits, vegetables, nuts, whole grains, fish and virgin olive oil (VOO) as a key component. It is well explained that those consumption has a number of positive health effects. It has been accepted for a long time that the leading compound in olive was oleic acid as a monounsaturated fatty acid. However, the latter researches were figured out that VOO rich in natural phenolics have multifaceted influence on major diseases including cancer, diabetes, cardiovascular diseases, neurodegenerative disease, and metabolic disorders. Recent medical studies proved that ol
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Cicerale, S., L. J., and R. S. J. Keast. "Oleocanthal: A Naturally Occurring Anti-Inflammatory Agent in Virgin Olive Oil." In Olive Oil - Constituents, Quality, Health Properties and Bioconversions. InTech, 2012. http://dx.doi.org/10.5772/28723.

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Nazir, Aqsa, Muhammad Aqib, and Muhammad Usman. "Liver Cancer-Genesis, Progression and Metastasis." In Liver Cancer - Genesis, Progression and Metastasis [Working Title]. IntechOpen, 2022. http://dx.doi.org/10.5772/intechopen.106020.

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Liver cancer or hepatocellular carcinoma (HCC) is a malignant tumor in liver tissue and worldwide it is fourth leading death cause among all cancers. The most common causes of liver cancer are hepatitis B or C virus infections, alcoholic liver disease (ALD), nonalcoholic fatty liver disease (NAFLD) to non-alcoholic steatohepatitis (NASH), smoking and obesity. The development and metastasis of liver cancer is a multistage and branched process of morphological and genetic traits. Various corresponding signaling pathways such as Yes-Associated Protein-Hippo Pathway (YAP-HIPPO), Wnt/β-catenin and
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El Sayed, Khalid A. "S-(−)-Oleocanthal as a c-Met receptor tyrosine kinase inhibitor and its application to synergize targeted therapies and prevent breast cancer recurrence." In Olives and Olive Oil in Health and Disease Prevention. Elsevier, 2021. http://dx.doi.org/10.1016/b978-0-12-819528-4.00037-7.

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"Good Taste is Required." In The Chemical Story of Olive Oil: From Grove to Table. The Royal Society of Chemistry, 2017. http://dx.doi.org/10.1039/9781782628569-00196.

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The bottom line for olive oil is how it tastes. We present an overview of the tasting process and explain how the human sensory apparatus interacts with the chemicals in the oil. Phenolic compounds that give rise to the bitterness and the oleocanthol that gives rise to the “burn” are featured here.
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Conference papers on the topic "Oleocanthal"

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Aydemir, Işıl. "The Effects of Atmospheric Plasma and Oleocanthal on Cancer Cell Migration." In 15th International Congress of Histochemistry and Cytochemistry. LookUs Scientific, 2017. http://dx.doi.org/10.5505/2017ichc.op-59.

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Siddique, Abu Bakar, Nehad M. Ayoub, and Khalid A. El Sayed. "Abstract 4810: Olive oil-derived (-)-oleocanthal for prevention of breast cancer recurrence." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.sabcs18-4810.

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Siddique, Abu Bakar, Nehad M. Ayoub, and Khalid A. El Sayed. "Abstract 4810: Olive oil-derived (-)-oleocanthal for prevention of breast cancer recurrence." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.am2019-4810.

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Nikou, T., K. V. Karampetsou, O. S. Koutsoni, et al. "Pharmacokinetics and metabolism of oleocanthal, a natural anti-inflammatory agent of olive oil." In GA – 70th Annual Meeting 2022. Georg Thieme Verlag KG, 2022. http://dx.doi.org/10.1055/s-0042-1759043.

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Li, W., M. Chountoulesi, L. Antoniadi, et al. "Development and physicochemical characterization of nanoliposomes with incorporated oleocanthal, oleacein, oleuropein and hydroxytyrosol." In GA – 69th Annual Meeting 2021, Virtual conference. Georg Thieme Verlag, 2021. http://dx.doi.org/10.1055/s-0041-1736909.

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Skaltsounis, L., I. Kostakis, G. Sarikaki, and P. Papakotsia. "Toward the Design and Synthesis of Novel Oleocanthal – Based compounds as Potential Anticancer Agents." In GA – 70th Annual Meeting 2022. Georg Thieme Verlag KG, 2022. http://dx.doi.org/10.1055/s-0042-1759235.

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Batarseh, Yazan, Hisham Qosa, Khalid Elsayed, Jeffrey N. Keller, and Amal Kaddoumi. "Extra-Virgin Olive Oil and Oleocanthal Reduce Amyloid ß Load in Alzheimer's Disease Mouse Model." In 2016 32nd Southern Biomedical Engineering Conference (SBEC). IEEE, 2016. http://dx.doi.org/10.1109/sbec.2016.42.

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Siddique, A., H. Yahia Mohamed, M. Mohyeldin, et al. "PO-406 The olive-based oleocanthal as a dual HER2-MET inhibitor for the control of breast cancer." In Abstracts of the 25th Biennial Congress of the European Association for Cancer Research, Amsterdam, The Netherlands, 30 June – 3 July 2018. BMJ Publishing Group Ltd, 2018. http://dx.doi.org/10.1136/esmoopen-2018-eacr25.432.

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Magiatis, P., F. Kalyva, P. Diamantakos, E. Melliou, and M. Nikolantonaki. "Short Lecture “New insights into the mechanism of action and bioavailability of oleocanthal and oleacein from olive oil”." In GA – 70th Annual Meeting 2022. Georg Thieme Verlag KG, 2022. http://dx.doi.org/10.1055/s-0042-1758968.

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Siddique, Abu Bakar, Hassan Y. Ebrahim, Mohamed R. Akl, Mohamed M. Mohyeldin, and Khalid A. El Sayed. "Abstract 1077: Extra-virgin olive oil Met inhibitor oleocanthal-lapatinib: a novel synergistic combination for HER2-dependent breast malignancies." In Proceedings: AACR Annual Meeting 2017; April 1-5, 2017; Washington, DC. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1538-7445.am2017-1077.

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