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Journal articles on the topic 'OLE'

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Published: 4 June 2021
Last updated: 20 February 2023

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1

Dunlop, Sarah. "Mongolia in Transition: Old Patterns, New Challenges. Ole Bruun , Ole Odgaard." China Journal 41 (January 1999): 236–38. http://dx.doi.org/10.2307/2667626.

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2

Carnes, J., and E. Fernandez-Caldas. "Ole e 4 and Ole e 5, important allergens of Olea europaea." Allergy 57, s71 (April 2002): 24–28. http://dx.doi.org/10.1034/j.1398-9995.2002.057s71024.x.

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3

Beale, Hugh. "Ole Lando." European Review of Private Law 27, Issue 4 (August 1, 2019): 689–93. http://dx.doi.org/10.54648/erpl2019038.

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4

Blumentha, Anita. "Gray, Ole!" Synergist 19, no. 4 (2008): 44. http://dx.doi.org/10.3320/1.2928482.

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5

Shell, Hanna Rose. "“Ole Cloes”." Thresholds 34 (January 2007): 82–83. http://dx.doi.org/10.1162/thld_a_00234.

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6

Redaktionen. "Ole Nørgaard." Politica 20, no. 1 (January 1, 1988): 122. http://dx.doi.org/10.7146/politica.v20i1.68976.

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7

Redaktionen. "Ole Nørgaard." Politica 23, no. 3 (January 1, 1991): 348. http://dx.doi.org/10.7146/politica.v23i3.69379.

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8

Henriksen, Tore. "Ole Espersen, Frederik Harhoff og Ole Spierman: Folkeret." Tidsskrift for Rettsvitenskap 118, no. 01-02 (July 28, 2005): 199–204. http://dx.doi.org/10.18261/issn1504-3096-2005-01-02-08.

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9

Haug, Charlotte. "Ole Brumm-syndromet." Tidsskrift for Den norske legeforening 130, no. 4 (2010): 363. http://dx.doi.org/10.4045/tidsskr.10.0207.

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10

Blix, Arnoldus S., Nicholas Tyler, and Odd Erling Smuk. "Ole Klemet Sara." Rangifer 33, no. 1 (September 1, 2013): iii. http://dx.doi.org/10.7557/2.33.1.2570.

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11

McGrail, Seán. "Ole Crumlin-Pedersen." Journal of Maritime Archaeology 6, no. 2 (December 2011): 101–6. http://dx.doi.org/10.1007/s11457-012-9083-z.

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12

Trakadas, Athena. "Ole Crumlin-Pedersen." Journal of Maritime Archaeology 6, no. 2 (December 2011): 95–100. http://dx.doi.org/10.1007/s11457-012-9084-y.

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13

Kirsch, Raymond P. "Teaching OLE automation." ACM SIGCSE Bulletin 28, no. 1 (March 1996): 68–72. http://dx.doi.org/10.1145/236462.236511.

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14

Andersen, Klaus Bahl, Boerge Diderichsen, Steen Petersen, Charles Kurland, James Friesen, Tove Atlung, Søren Molin, et al. "Honoring Ole Maaløe." Microbe Magazine 1, no. 5 (May 1, 2006): 210–11. http://dx.doi.org/10.1128/microbe.1.210.1.

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15

Huguet-Casquero, Amaia, Maria Moreno-Sastre, Tania Belén López-Méndez, Eusebio Gainza, and Jose Luis Pedraz. "Encapsulation of Oleuropein in Nanostructured Lipid Carriers: Biocompatibility and Antioxidant Efficacy in Lung Epithelial Cells." Pharmaceutics 12, no. 5 (May 6, 2020): 429. http://dx.doi.org/10.3390/pharmaceutics12050429.

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Oxidative damage has been linked to a number of diseases. Oleuropein (OLE), a natural occurring polyphenol from olive leaves (Olea europaea L.), is known to be a potent antioxidant compound with inherent instability and compromised bioavailability. Therefore, in this work, nanostructured lipid carriers (NLCs) were proposed for OLE encapsulation to protect and improve its antioxidant efficacy. The lipid matrix, composed of olive oil and Precirol, was optimized prior to OLE encapsulation. The characterization of the optimized oleuropein-loaded NLCs (NLC-OLE) showed a mean size of 150 nm, a zeta potential of −21 mV, an encapsulation efficiency of 99.12%, sustained release profile, and improved radical scavenging activity. The cellular in vitro assays demonstrated the biocompatibility of the NLCs, which were found to improve and maintain OLE antioxidant efficacy in the A549 and CuFi-1 lung epithelial cell lines, respectively. Overall, these findings suggest a promising potential of NLC-OLE to further design a pulmonary formulation for OLE delivery in lung epithelia.
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16

Ruzzolini, Jessica, Silvia Peppicelli, Elena Andreucci, Francesca Bianchini, Arianna Scardigli, Annalisa Romani, Giancarlo la Marca, Chiara Nediani, and Lido Calorini. "Oleuropein, the Main Polyphenol of Olea europaea Leaf Extract, Has an Anti-Cancer Effect on Human BRAF Melanoma Cells and Potentiates the Cytotoxicity of Current Chemotherapies." Nutrients 10, no. 12 (December 8, 2018): 1950. http://dx.doi.org/10.3390/nu10121950.

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Oleuropein (Ole), a secoiridoid glucoside present in Olea europaea leaves, gained scientific interest thanks to its several biological properties, including the anticancer one. We verified whether Ole might potentiate the cytotoxicity of conventional drugs used to treat melanoma, disclosing a potentially new therapeutic strategy. We tested the cytotoxic action of Ole alone or in combination with chemotherapeutics on A375 human melanoma cells. We found that Ole was able, at a dose of 500 µM, to stimulate apoptosis, while at a non-toxic dose of 250 µM, it affected cell proliferation and induced the downregulation of the pAKT/pS6 pathway. A dose of 250 µM Ole did not potentiate the effect of Vemurafenib (PLX4032), but it succeeded in increasing the cytotoxic effect of Dacarbazine (DTIC). The major effect was found in the association between Ole and Everolimus (RAD001), also on PLX4032-resistant BRAF melanoma cells, which possibly cooperate in the inhibition of the pAKT/pS6 pathway. Of interest, an olive leaf extract enriched in equimolar Ole was more effective and able to further improve DTIC and RAD001 efficacy on BRAF melanoma cells with respect to Ole alone. Therefore, Ole represents a natural product able to potentiate a wide array of chemotherapeutics against BRAF melanoma cells affecting the pAKT/pS6 pathway.
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17

Dekanski, Dragana, Slavica Ristic, Nevena Radonjic, Natasa Petronijevic, Aleksandar Dekanski, and Dusan Mitrovic. "Olive leaf extract modulates cold restraint stress-induced oxidative changes in rat liver." Journal of the Serbian Chemical Society 76, no. 9 (2011): 1207–18. http://dx.doi.org/10.2298/jsc110204107d.

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Recently, demonstrated the beneficial effects of different single doses of standardized dry olive (Olea europaea L.) leaf extract (OLE) in cold restraint stress (CRS)-induced gastric lesions in rats and its influence on oxidative parameters in gastric mucosa were demonstrated. The present study was undertaken to investigate the long-term pretreatment efficacy of OLE and its potential in the modulation of CRS-induced oxidative changes at the liver level. The experimental animals were divided into four groups, i.e., control, OLE-treated, CRS non-treated and CRS treated with OLE (CRS+OLE) groups. CRS caused severe gastric lesions in all non-pretreated animals and two-week pretreatment with OLE (80 mg kg-1 b.w.) attenuated stress-induced gastric lesions significantly. The malondialdehyde (MDA) level as an index of lipid peroxidation, superoxide dismutase (SOD) and catalase (CAT) activities were measured spectrophotometrically in liver tissue homogenates. The MDA level was increased in the CRS group and significantly decreased in the CRS+OLE group. The SOD and CAT activities were significantly decreased in the CRS group. In the CRS+OLE group, the activities of these two enzymes were significantly increased in comparison with the CRS group. The results obtained indicate that long-term supplementation with OLE provides oxidant/antioxidant balance in liver during stress condition.
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18

Shen, Ying, Su Jin Song, Narae Keum, and Taesun Park. "Olive Leaf Extract Attenuates Obesity in High-Fat Diet-Fed Mice by Modulating the Expression of Molecules Involved in Adipogenesis and Thermogenesis." Evidence-Based Complementary and Alternative Medicine 2014 (2014): 1–12. http://dx.doi.org/10.1155/2014/971890.

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The present study aimed to investigate whether olive leaf extract (OLE) prevents high-fat diet (HFD)-induced obesity in mice and to explore the underlying mechanisms. Mice were randomly divided into groups that received a chow diet (CD), HFD, or 0.15% OLE-supplemented diet (OLD) for 8 weeks. OLD-fed mice showed significantly reduced body weight gain, visceral fat-pad weights, and plasma lipid levels as compared with HFD-fed mice. OLE significantly reversed the HFD-induced upregulation of WNT10b- and galanin-mediated signaling molecules and key adipogenic genes (PPARγ, C/EBPα, CD36, FAS, and leptin) in the epididymal adipose tissue of HFD-fed mice. Furthermore, the HFD-induced downregulation of thermogenic genes involved in uncoupled respiration (SIRT1, PGC1α, and UCP1) and mitochondrial biogenesis (TFAM, NRF-1, and COX2) was also significantly reversed by OLE. These results suggest that OLE exerts beneficial effects against obesity by regulating the expression of genes involved in adipogenesis and thermogenesis in the visceral adipose tissue of HFD-fed mice.
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19

De la Ossa, Felice, Azimi, Salsano, Digiacomo, Macchia, Danti, and Di Stefano. "Waste Autochthonous Tuscan Olive Leaves (Olea europaea var. Olivastra seggianese) as Antioxidant Source for Biomedicine." International Journal of Molecular Sciences 20, no. 23 (November 25, 2019): 5918. http://dx.doi.org/10.3390/ijms20235918.

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Olive leaf extract (OLE) can be obtained as biowaste and is extensively used a food supplement and an over-the-counter drug for its beneficial effects. New studies have investigated OLE concerning the role of oxidative stress in the pathogenesis of vascular disease. This in vitro study aims to evaluate if OLE extracted from the Tuscan Olea europaea protects endothelial cells against oxidative stress generated by reactive oxygen species (ROS). Methods: OLE total polyphenols (TPs) were characterized by the Folin–Ciocalteu method. Endothelial cells were grown in conventional cultures (i.e., two-dimensional, 2D) and on a biomaterial scaffold (i.e., three-dimensional, 3D) fabricated via electrospinning. Cell viability and ROS measurement after H2O2 insults were performed. Results: OLE TP content was 23.29 mg GAE/g, and oleuropein was the principal compound. The dose-dependent viability curve highlighted the absence of significant cytotoxic effects at OLE concentrations below 250 µg/mL TPs. By using OLE preconditioning at 100 µg/mL, cell viability decrease was observed, being in 3D lower than in the 2D model. OLE was protective against ROS in both models. Conclusions: OLE represents a high-value antioxidant source obtained by biowaste that is interesting for biomedical products. Using a 3D scaffold could be the best predictive model to mimic the physiological conditions of vascular tissue reaction.
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20

Scala, Enrico, Damiano Abeni, Debora Pomponi, Roberto Paganelli, Maria Locanto, Mauro Giani, Lorenzo Cecchi, and Riccardo Asero. "Ole e 1, Ole e 7, and Ole e 9: Identifying distinct clinical subsets of olive tree–allergic patients." Journal of Allergy and Clinical Immunology 137, no. 2 (February 2016): 629–31. http://dx.doi.org/10.1016/j.jaci.2015.07.009.

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21

Schovsbo, Jens. "Ole-Andreas Rognstad: Opphavsrett." Tidsskrift for Rettsvitenskap 123, no. 04-05 (January 13, 2011): 870–75. http://dx.doi.org/10.18261/issn1504-3096-2010-04-05-15.

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22

Haakonssen, Knud, and Sebastian Olden-Jørgensen. "Svar til Ole Thomsen." 1700-tal: Nordic Journal for Eighteenth-Century Studies 17 (October 1, 2020): 225–28. http://dx.doi.org/10.7557/4.5648.

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23

Gregersen, Niels Henrik. "Ole Nyborg in memoriam." Grundtvig-Studier 65, no. 1 (May 29, 2015): 10–14. http://dx.doi.org/10.7146/grs.v65i1.20936.

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24

Park, S. J., F. Kiehn, and T. Rupert. "AC OLE common bean." Canadian Journal of Plant Science 79, no. 1 (January 1, 1999): 107–8. http://dx.doi.org/10.4141/p98-019.

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AC Ole is a high-yielding pinto bean (Phaseolus vulgaris L.) cultivar with mid-season maturity. It has high yield potential and an upright plant type, suitable for direct combine harvest. AC Ole seed has acceptable cooking/canning quality. It is resistant to races 1 and 15 of bean common mosaic virus. Key words: Phaseolus vulgaris, dry bean, cultivar description
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25

Kallo, Johanna. "Koulutus ei ole Bonanza." Aikuiskasvatus 23, no. 3 (September 15, 2003): 243–44. http://dx.doi.org/10.33336/aik.93503.

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26

Pätäri, Jenni. ""Valintamme eivät ole vapaita"." Aikuiskasvatus 37, no. 2 (May 15, 2017): 154–55. http://dx.doi.org/10.33336/aik.88424.

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27

Klemsdal, Tor Ole. "Tor Ole Klemsdal svarer:." Tidsskrift for Den norske legeforening 133, no. 6 (2013): 614. http://dx.doi.org/10.4045/tidsskr.13.0277.

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28

Jenny, Samantha Anne. "Good Ole Girls Club." Journal of Transcultural Nursing 30, no. 2 (September 15, 2018): 95. http://dx.doi.org/10.1177/1043659618799848.

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29

Segee, B. E., and Kevin S. LeBlanc. "Industrial automation using OLE." Computer Standards & Interfaces 20, no. 6-7 (March 1999): 435. http://dx.doi.org/10.1016/s0920-5489(99)90880-2.

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30

Kjeldgaard, Niels Ole. "Ole Maaløe (1915–1988)." Trends in Biochemical Sciences 14, no. 2 (February 1989): 51. http://dx.doi.org/10.1016/0968-0004(89)90042-x.

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31

Paul, Peter V. "Good Ole Summertime Musings." American Annals of the Deaf 161, no. 4 (2016): 403–5. http://dx.doi.org/10.1353/aad.2016.0032.

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32

Fels, Gregor. "Biblio im OLE-Gewand." Nachrichten aus Chemie, Technik und Laboratorium 43, no. 12 (December 1995): 1312–19. http://dx.doi.org/10.1002/nadc.19950431216.

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33

Öhrn, Yngve, and Jan Linderberg. "Linda and Ole Halkjaer." International Journal of Quantum Chemistry 16, S13 (June 19, 2009): 485. http://dx.doi.org/10.1002/qua.560160850.

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34

Bringeland, Hans. "Ole Hallesby og fascismen." Teologisk tidsskrift 11, no. 4 (December 9, 2022): 229–45. http://dx.doi.org/10.18261/tt.11.4.5.

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35

Dreyer, Kirsten. "Det er en deilig Fætter, den Ole! H.C. Andersen og Ole Bull." Magasin fra Det Kongelige Bibliotek 24, no. 2 (June 1, 2011): 38–55. http://dx.doi.org/10.7146/mag.v24i2.66702.

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36

Barral, Patricia, Mayte Villalba, Rosalí Rodíguez, and Eva Batanero. "The role of major olive pollen allergens Ole e 1, Ole e 9, and Ole e 10 on mice sensitization." Annals of Allergy, Asthma & Immunology 96, no. 3 (March 2006): 466–71. http://dx.doi.org/10.1016/s1081-1206(10)60915-5.

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37

Machado, Noelia D., Cristina Cejudo-Bastante, María L. Goñi, Nicolás A. Gañán, Lourdes Casas-Cardoso, and Casimiro Mantell-Serrano. "Screening of the Supercritical Impregnation of Olea europaea Leaves Extract into Filaments of Thermoplastic Polyurethane (TPU) and Polylactic Acid (PLA) Intended for Biomedical Applications." Antioxidants 11, no. 6 (June 14, 2022): 1170. http://dx.doi.org/10.3390/antiox11061170.

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The leaves of Olea europaea as agricultural waste represent a convenient source of antioxidants. In combination with supercritical CO2 (scCO2), assisted impregnation is an interesting strategy for the preparation of biomedical devices with specific bioactivity. For this purpose, 3D-printable filaments of thermoplastic polyurethane (TPU) and polylactic acid (PLA) were employed for the supercritical impregnation of ethanolic olive leaves extract (OLE) for biomedical application. The extraction of OLE was performed using pressurized liquids. The effect of pressure (100–400 bar), temperature (35–55 °C), and the polymer type on the OLE impregnation and the swelling degree were studied including a morphological analysis and the measurement of the final antioxidant activity. All the studied variables as well as their interactions showed significant effects on the OLE loading. Higher temperatures favored the OLE loading while the pressure presented opposite effects at values higher than 250 bar. Thus, the highest OLE loadings were achieved at 250 bar and 55 °C for both polymers. However, TPU showed c.a. 4 times higher OLE loading and antioxidant activity in comparison with PLA at the optimal conditions. To the best of our knowledge, this is the first report using TPU for the supercritical impregnation of a natural extract with bioactivity.
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38

González-Hedström, Daniel, Teresa Priego, Sara Amor, María de la Fuente-Fernández, Ana Isabel Martín, Asunción López-Calderón, Antonio Manuel Inarejos-García, Ángel Luís García-Villalón, and Miriam Granado. "Olive Leaf Extract Supplementation to Old Wistar Rats Attenuates Aging-Induced Sarcopenia and Increases Insulin Sensitivity in Adipose Tissue and Skeletal Muscle." Antioxidants 10, no. 5 (May 7, 2021): 737. http://dx.doi.org/10.3390/antiox10050737.

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Aging is associated with increased visceral adiposity and a decrease in the amount of brown adipose tissue and muscle mass, known as sarcopenia, which results in the development of metabolic alterations such as insulin resistance. In this study, we aimed to analyze whether 3-week supplementation with a phenolic-rich olive leaf extract (OLE) to 24 months-old male Wistar rats orally (100 mg/kg) attenuated the aging-induced alterations in body composition and insulin resistance. OLE treatment increased brown adipose tissue and attenuated the aging-induced decrease in protein content and gastrocnemius weight. Treatment with OLE prevented the aging-induced increase in the expression of PPAR-γ in visceral and brown adipose tissues, while it significantly increased the expression of PPAR-α in the gastrocnemius of old rats and reduced various markers related to sarcopenia such as myostatin, HDAC-4, myogenin and MyoD. OLE supplementation increased insulin sensitivity in explants of gastrocnemius and epididymal visceral adipose tissue from aged rats through a greater activation of the PI3K/Akt pathway, probably through the attenuation of inflammation in both tissues. In conclusion, supplementation with OLE prevents the loss of muscle mass associated with aging and exerts anti-inflammatory and insulin-sensitizing effects on adipose tissue and skeletal muscle.
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39

Mcewan, Bonnie G. "Maiolica Ole: Spanish and Mexican Decorative Traditions:Maiolica Ole: Spanish and Mexican Decorative Traditions." Museum Anthropology 26, no. 1 (March 2003): 78–79. http://dx.doi.org/10.1525/mua.2003.26.1.78.

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40

Machała, Paulina, Oleksandra Liudvytska, Agnieszka Kicel, Angela Dziedzic, Monika A. Olszewska, and Halina Małgorzata Żbikowska. "Valorization of the Photo-Protective Potential of the Phytochemically Standardized Olive (Olea europaea L.) Leaf Extract in UVA-Irradiated Human Skin Fibroblasts." Molecules 27, no. 16 (August 12, 2022): 5144. http://dx.doi.org/10.3390/molecules27165144.

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Leaves of Olea europaea are a by-product of the olive oil industry and a dietary supplement with acknowledged antioxidant and anti-inflammatory activity but underestimated photoprotective potential. We investigated the protective effects of the LC-PDA-MS/MS standardized ethanol-water extract of olive leaves (OLE), containing 26.2% total phenols and 22.2% oleuropein, with underlying mechanisms against the UVA-induced oxidative damage in human dermal fibroblasts. Hs68 cells were pre-treated (24 h) with OLE (2.5–25 μg/mL) or the reference antioxidants, quercetin and ascorbic acid (25 μg/mL), followed by irradiation (8 J/cm2). OLE significantly reduced the UVA-induced DNA damage and reactive oxygen species (ROS) overproduction and increased the thioredoxin reductase (TrxR) expression and post-radiation viability of fibroblasts by inhibiting their apoptosis. Both intrinsic and extrinsic apoptotic signaling pathways appeared to be inhibited by OLE, but the activity of caspase 9 was the most reduced. We hypothesized that the TrxR up-regulation by OLE could have prevented the UVA-induced apoptosis of Hs68 cells. In addition, a significant decrease in UVA-induced secretion levels of tumor necrosis factor (TNF-α) and interleukin-2 (IL-2) was shown in human lymphocyte culture in response to OLE treatment. In summary, our results support the beneficial effect of OLE in an in vitro model and indicate its great potential for use in the cosmetic and pharmaceutical industry as a topical photoprotective, antioxidant, and anti-inflammatory agent.
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41

Ilic, Sonja, Nenad Stojiljkovic, Nikola Stojanovic, Milan Stoiljkovic, Katarina Mitic, Sonja Salinger-Martinovic, and Pavle Randjelovic. "Effects of oleuropein on rat’s atria and thoracic aorta: a study of antihypertensive mechanisms." Canadian Journal of Physiology and Pharmacology 99, no. 1 (January 2021): 110–14. http://dx.doi.org/10.1139/cjpp-2020-0363.

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Oleuropein (OLE) is the main bioactive ingredient in the leaves of the olive plant Olea europaea L. (Oleaceae), which has proven beneficial due to the antiinflammatory, antiatherogenic, anticancer, antimicrobial, and antiviral effects. This study aimed to investigate the antihypertensive and vasodilator potential of OLE by analyzing its acute effects on spontaneous atrial contractions and vasomotor responses of the isolated thoracic aorta in rats. We showed that the application of OLE induces negative chronotropic and inotropic effects on the heart. OLE also causes mild aortic vasodilation given that the maximal reduction in tension of intact aortic rings precontracted with phenylephrine was approximately 30%. This vasodilation is likely dependent on the nitric oxide released from the endothelium based on the effect obtained on denuded and phenylephrine precontracted aortic rings and responses reordered following vasoconstriction induced by high concentrations of K+ and heparin. Our findings provide a basis for further testing of OLE cardiovascular effects, which may lead to subsequent clinical research for its application in the treatment of hypertension and heart disease.
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42

Lepore, Saverio Massimo, Valeria Maria Morittu, Marilena Celano, Francesca Trimboli, Manuela Oliverio, Antonio Procopio, Carla Di Loreto, et al. "Oral Administration of Oleuropein and Its Semisynthetic Peracetylated Derivative Prevents Hepatic Steatosis, Hyperinsulinemia, and Weight Gain in Mice Fed with High Fat Cafeteria Diet." International Journal of Endocrinology 2015 (2015): 1–9. http://dx.doi.org/10.1155/2015/431453.

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The high consumption of olive tree products in the Mediterranean diet has been associated with a lower incidence of metabolic disorders and cardiovascular diseases. In particular, the protective effects of olive oil have been attributed to the presence of polyphenols such as oleuropein (Ole) and its derivatives. We have synthesized a peracetylated derivative of Ole (Ac-Ole) which has shownin vitroantioxidant and growth-inhibitory activity higher than the natural molecule. In this study, male C57BL/6JOlaHsd mice were fed with a standard (std), cafeteria (caf) diet, and caf diet supplemented with Ole (0.037 mmol/kg/day) and Ac-Ole (0.025 mmol/kg/day) for 15 weeks. We observed a significant reduction in the caf diet-induced body weight gain and increase of abdominal adipose tissue. Also, Ole and Ac-Ole prevented the development of hepatic steatosis. Finally, Ole and Ac-Ole determined a lower increase of HDL and LDL-cholesterol levels and corrected caf diet-induced elevation of plasma glucose concentrations by improving insulin sensitivity. The observed beneficial properties of Ole and Ac-Ole make these compounds and in particular Ac-Ole promising candidates for a potential pharmaceutic use in metabolic disorders.
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43

Difonzo, Graziana, Michela Pia Totaro, Francesco Caponio, Antonella Pasqualone, and Carmine Summo. "Olive Leaf Extract (OLE) Addition as Tool to Reduce Nitrate and Nitrite in Ripened Sausages." Foods 11, no. 3 (February 3, 2022): 451. http://dx.doi.org/10.3390/foods11030451.

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Olive leaf extract (OLE) is known to be a source of phenolic compounds with antioxidant and antimicrobial activities. This study investigated the effects of the OLE addition to reduce nitrate/nitrite (NO) content on the physico-chemical features of ripened pork sausages. Seven formulations of pork sausages were set up: CTRL (0 mg/kg OLE; 300 mg/kg NO), Tr1 (200 mg/kg OLE; 150 mg/kg NO), Tr2 (400 mg/kg OLE; 150 mg/kg NO), Tr3 (800 mg/kg OLE; 150 mg/kg NO), Tr4 (200 mg/kg OLE; 0 mg/kg NO), Tr5 (400 mg/kg OLE; 0 mg/kg NO), and Tr6 (800 mg/kg OLE; 0 mg/kg NO). At the end of the ripening period, all the samples were within hygienic limits and the substitution of the additives with OLE allowed the reduction of NO residual contents. Both OLE and NO influenced the colour parameters. At the highest dose of OLE, both alone and in combination with reduced dose of NO, no significant differences in terms of moisture, pH, and aw were found compared to CTRL. In absence of NO, a significant reduction of weight loss was observed. Moreover, in the samples without NO a reduction of the hardness was detected. Finally, the oxidative stability test showed that the increase of the OLE amount prolonged the induction time.
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44

Yang, Yang, Kimberly A. Harris, Danielle L. Widner, and Ronald R. Breaker. "Structure of a bacterial OapB protein with its OLE RNA target gives insights into the architecture of the OLE ribonucleoprotein complex." Proceedings of the National Academy of Sciences 118, no. 9 (February 22, 2021): e2020393118. http://dx.doi.org/10.1073/pnas.2020393118.

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The OLE (ornate, large, and extremophilic) RNA class is one of the most complex and well-conserved bacterial noncoding RNAs known to exist. This RNA is known to be important for bacterial responses to stress caused by short-chain alcohols, cold, and elevated Mg2+concentrations. These biological functions have been shown to require the formation of a ribonucleoprotein (RNP) complex including at least two protein partners: OLE-associated protein A (OapA) and OLE-associated protein B (OapB). OapB directly binds OLE RNA with high-affinity and specificity and is believed to assist in assembling the functional OLE RNP complex. To provide the atomic details of OapB–OLE RNA interaction and to potentially reveal previously uncharacterized protein–RNA interfaces, we determined the structure of OapB fromBacillus haloduransalone and in complex with an OLE RNA fragment at resolutions of 1.0 Å and 2.0 Å, respectively. The structure of OapB exhibits a K-shaped overall architecture wherein its conserved KOW motif and additional unique structural elements of OapB form a bipartite RNA-binding surface that docks to the P13 hairpin and P12.2 helix of OLE RNA. These high-resolution structures elucidate the molecular contacts used by OapB to form a stable RNP complex and explain the high conservation of sequences and structural features at the OapB–OLE RNA-binding interface. These findings provide insight into the role of OapB in the assembly and biological function of OLE RNP complex and can guide the exploration of additional possible OLE RNA-binding interactions present in OapB.
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45

Sukovich, David J., Jennifer L. Seffernick, Jack E. Richman, Jeffrey A. Gralnick, and Lawrence P. Wackett. "Widespread Head-to-Head Hydrocarbon Biosynthesis in Bacteria and Role of OleA." Applied and Environmental Microbiology 76, no. 12 (April 23, 2010): 3850–62. http://dx.doi.org/10.1128/aem.00436-10.

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ABSTRACT Previous studies identified the oleABCD genes involved in head-to-head olefinic hydrocarbon biosynthesis. The present study more fully defined the OleABCD protein families within the thiolase, α/β-hydrolase, AMP-dependent ligase/synthase, and short-chain dehydrogenase superfamilies, respectively. Only 0.1 to 1% of each superfamily represents likely Ole proteins. Sequence analysis based on structural alignments and gene context was used to identify highly likely ole genes. Selected microorganisms from the phyla Verucomicrobia, Planctomyces, Chloroflexi, Proteobacteria, and Actinobacteria were tested experimentally and shown to produce long-chain olefinic hydrocarbons. However, different species from the same genera sometimes lack the ole genes and fail to produce olefinic hydrocarbons. Overall, only 1.9% of 3,558 genomes analyzed showed clear evidence for containing ole genes. The type of olefins produced by different bacteria differed greatly with respect to the number of carbon-carbon double bonds. The greatest number of organisms surveyed biosynthesized a single long-chain olefin, 3,6,9,12,15,19,22,25,28-hentriacontanonaene, that contains nine double bonds. Xanthomonas campestris produced the greatest number of distinct olefin products, 15 compounds ranging in length from C28 to C31 and containing one to three double bonds. The type of long-chain product formed was shown to be dependent on the oleA gene in experiments with Shewanella oneidensis MR-1 ole gene deletion mutants containing native or heterologous oleA genes expressed in trans. A strain deleted in oleABCD and containing oleA in trans produced only ketones. Based on these observations, it was proposed that OleA catalyzes a nondecarboxylative thiolytic condensation of fatty acyl chains to generate a β-ketoacyl intermediate that can decarboxylate spontaneously to generate ketones.
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46

Fabiano, Angela, Chiara Migone, Luca Cerri, Anna Maria Piras, Andrea Mezzetta, Giuseppantonio Maisetta, Semih Esin, Giovanna Batoni, Rossella Di Stefano, and Ylenia Zambito. "Combination of Two Kinds of Medicated Microparticles Based on Hyaluronic Acid or Chitosan for a Wound Healing Spray Patch." Pharmaceutics 13, no. 12 (December 18, 2021): 2195. http://dx.doi.org/10.3390/pharmaceutics13122195.

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Olive leaves extract (OLE) has been extensively studied as antioxidant and antibiotic and these characteristics make it particularly interesting for use on wounds. For this reason, the aim of this study was to introduce OLE in microparticles (MP) of hyaluronic acid (MPHA-OLE) or chitosan (MPCs-OLE) to obtain a spray patch for the treatment of wounds in anatomical areas that are difficult to protect with traditional patches. The MP were characterized for particle size and ability to protect OLE from degradation, to absorb water from wound exudate, to control OLE release from MP. The MPHA and MPCs medicated or not and mixtures of the two types in different proportions were studied in vitro on fibroblasts by the scratch wound healing assay. The MP size was always less than 5 µm, and therefore, suitable for a spray patch. The MPCs-OLE could slow down the release of OLE therefore only about 60% of the polyphenols contained in it were released after 4 h. Both MPHA and MPCs could accelerate wound healing. A 50% MPHA-OLE-50% MPCs-OLE blend was the most suitable for accelerating wound healing. The MPHA-OLE-MPCs-OLE blends studied in this work were shown to have the characteristics suitable for a spray patch, thus giving a second life to the waste products of olive growers.
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Özeren, Nurefşan, Mehmet Ali Kisacam, Gonca Ozan Kocamuftuoglu, Nalan Kaya, and Sema Temizer Ozan. "The protective role of oleuropein against diethylnitrosamine and phenobarbital induced damage in rats." Turkish Journal of Biochemistry 44, no. 5 (October 25, 2019): 714–21. http://dx.doi.org/10.1515/tjb-2018-0166.

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Abstract Objective Liver cancer is amongst the most lethal cancers worldwide. Diethylnitrosamine (DEN) and phenobarbital (PB) are common agents that form reactive oxygen species (ROS). Oleuropein (OLE) has efficient biological properties and used as a therapeutic agent. In this study, we aimed at investigating OLE against DEN + PB induced liver damage. Methods Adult Sprague-Dawley rats were divided into 5 groups (n = 10): Control, DEN, DEN + PB, DEN + PB + OLE and OLE. DEN, DEN + PB, DEN + PB + OLE groups were administered a single dose of 150 mg/kg DEN. After two weeks, DEN + PB and DEN + PB + OLE groups received 500 ppm of PB. 10 mg/kg/day of OLE was orally administered to DEN + PB + OLE and OLE groups. Biochemical and histopathological changes evaluated after the 8 weeks study. Results DEN and PB application with OLE treatment resulted significant differences, alone or combined. Although there was a significant difference among the groups in terms of liver GSH and MDA levels and CAT activities, there was no significant difference among the groups in SOD activity. In the liver sections of the DEN, DEN + PB and OLE groups, increase in some histopathological findings and TUNEL positive cells were increased compared to the control group. Conclusion OLE can be used as a protector against the effects of carcinogens causing liver damage.
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48

Raditya, Michael HB. "Musik sebagai Wujud Eksistensi dalam Gelaran World Cup." Resital: Jurnal Seni Pertunjukan 15, no. 1 (November 10, 2014): 83–99. http://dx.doi.org/10.24821/resital.v15i1.802.

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We Are One atau “Ole Ola” merupakan lagu resmi dari gelaran World Cup. Setiap World Cupmempunyai lagu resminya ditiap gelarannya. Dalam keberlangsungannya, setiap lagu world cupmembutuhkan pertimbangan dalam pembentukannya. Aspek-aspek seperti budaya, sosial, politikdan lainya menjadi alasan penting dalam pembentukannya. Pembentukan Ole Ola didasarkan padaproses hibriditas budaya lokal dan global. Perpaduan samba dan hip hop menjadi variant dalampembentukannya. Perpaduan tersebut membentuk identitas untuk lagu itu sendiri, dan untuk gelaranworld cup. Eksistensi dari lagu sehingga makin terasa karena perpaduan yang membentuk identitas.Terlebih lagu tersebut tercipta tidak hanya karena gelaran, tetapi mempunyai fungsi dan guna untukmasyarakat. Musik sebagai media dalam mengkonstruksi pesan atas kepentingan. Musik membentukidentitas, dan mempunyai eksistensi dalam keberlangsungannya. Musik tidak lagi hanya berfungsisebagai musik saja, tetapi musik mempunyai peran dalam pembentukan identitas dan menjamineksistensi.Music as a form of Existance in the World Cup Performance. We are one or Ole Ola is the officialsong of the world cup performance. Every world cup has its official song in each event. In its development ofexistance, every song in world cup needs requires of consideration for creating process. Aspects such as cultural,social, politics and others become the important reason for creation. The creating proses of Ole Ola song isbased on the local and global cultural hybridity. The combination of samba and hip hop is a primary varianton creating process. The combination creates an identity for the song itself, and for world cup identity. Theexistance of Ole Ola is stronger because the combination may create the new identity. Moreover, the songcreated is not only for the event, but also has a function and purpose to society. Music is as a medium inconstructing the messages of interest. Music creates an identity, and has an existance in its continuty. Musicis not only for music itself, but also has a role in creating identity and ensures the existance.
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Blondel, Éric. "Ole Hansen-Løve (1948-2020)." Revue philosophique de la France et de l'étranger 146, no. 1 (2021): 151. http://dx.doi.org/10.3917/rphi.211.0151.

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50

Storsæter, Odd. "Stopp hetsen av Ole Brumm!" Tidsskrift for Den norske legeforening 130, no. 7 (2010): 722. http://dx.doi.org/10.4045/tidsskr.10.0295.

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