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Journal articles on the topic 'Old Man Range (N.Z.)'

Author: Grafiati

Published: 4 June 2021

Last updated: 19 February 2022

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1

Maraston, C., L. Hill, D. Thomas, et al. "Stellar population models based on the SDSS-IV MaStar library of stellar spectra – I. Intermediate-age/old models." Monthly Notices of the Royal Astronomical Society 496, no. 3 (2020): 2962–97. http://dx.doi.org/10.1093/mnras/staa1489.

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ABSTRACT We use the first release of the SDSS/MaStar stellar library comprising ∼9000, high S/N spectra, to calculate integrated spectra of stellar population models. The models extend over the wavelength range 0.36–1.03 µm and share the same spectral resolution ($R\sim 1800$) and flux calibration as the SDSS-IV/MaNGA galaxy data. The parameter space covered by the stellar spectra collected thus far allows the calculation of models with ages and chemical composition in the range $\rm {\mathit{ t}\gt 200 \,Myr, -2 \lt = [Z/H] \lt = + 0.35}$, which will be extended as MaStar proceeds. Notably, t

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Koval, O. A., O. M. Klygunenko, and O. Yu Muryzina. "Coagulation properties of the blood coagulation system in acute pulmonary embolism and their dynamics against the background of systemic thrombolytic therapy for patients with different risk of hospital mortality." Ukrainian Journal of Cardiology 27, no. 1 (2020): 27–38. http://dx.doi.org/10.31928/1608-635x-2020.1.2738.

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The aim – to evaluate the dynamics of blood coagulation changes in patients with acute pulmonary embolism before and after systemic thrombolytic therapy (TLT), by comparing high and intermediate-high risk groups. Materials and methods. 45 patients, 29 male (62 %) and 17 female (38 %), 55.6±13.6 years old admitted into an intensive care unit with the first episode of acute PE and received systemic thrombolysis, were included into prospective nonrandomized investigation. Accoding to the ESC Guideline on pulmonary embolism (2014) these patients were split into two groups: unstable high-risk pulmo

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Góralski, Wojciech. "Poważny brak rozeznania oceniającego (kan. 1095, n. 2 KPK) w wyroku Roty Rzymskiej c. Caberletti z 20 listopada 2018 roku." Ius Matrimoniale 31, no. 2 (2020): 91–114. http://dx.doi.org/10.21697/im.2020.31.2.05.

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The sentence of the Roman Rota, c. Caberletti, concerns the marriage of a 34-year-old man, which was concluded in a certain haste. Therefore, from the very beginning the parties lived side by side, and after less than two years they broke up. The immediate reason for the claimant's departure was the defendant's infertility. The case for nullity was initiated by a man pointing to two grounds of nullity: a mistake as to the attribute of a woman intended directly and principally (can. 1097 § 2 CIC) and the exclusion of the indissolubility of marriage by the woman (can. 1101 § 2 CIC). After the ha

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Carrigg, Bronwyn, Elise Baker, Louise Parry, and Kirrie J. Ballard. "Persistent Speech Sound Disorder in a 22-Year-Old Male: Communication, Educational, Socio-Emotional, and Vocational Outcomes." Perspectives on School-Based Issues 16, no. 2 (2015): 37–49. http://dx.doi.org/10.1044/sbi16.2.37.

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Persistent Speech Disorder (PSD) is present when a speech impairment extends beyond 8–9 years of age. Persistent Speech Disorder can extend into adolescence and adulthood. While PSD can include individuals with residual speech errors, such as distortions of /r/, /s/, and /z/, clinicians are particularly concerned in cases where PSD affects speech intelligibility. This paper is presented in two parts. Part 1 reviews the limited literature available on speech, language, literacy, educational, vocational, and socio-emotional outcomes in people with PSD of currently unknown origin. Part 2 presents

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Al-Najjar, Mohammad A. A., and Majed M. Albokari. "Shifts in microbial community composition in tannery-contaminated soil in response to increased gamma radiation." Annals of Microbiology 69, no. 13 (2019): 1567–77. http://dx.doi.org/10.1007/s13213-019-01541-z.

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Abstract Purpose Contaminated sites from man-made activities such as old-fashioned tanneries are inhabited by virulent microorganisms that exhibit more resistance against extreme and toxic environmental conditions. We investigated the effect of different Gamma radiation doses on microbial community composition in the sediment of an old-fashioned tannery. Methods Seven samples collected from the contaminated sites received different gamma radiation doses (I = 0.0, II = 5, III = 10, VI = 15, V = 20, VI = 25, and VII = 30 kGy) as an acute exposure. The shift in microbial community structure was a

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Shelton, Chasity M., Amanda J. Clark, Michael C. Storm, and Richard A. Helms. "Plasma Amino Acid Concentrations in 108 Children Receiving a Pediatric Amino Acid Formulation as Part of Parenteral Nutrition." Journal of Pediatric Pharmacology and Therapeutics 15, no. 2 (2010): 110–18. http://dx.doi.org/10.5863/1551-6776-15.2.110.

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ABSTRACT BACKGROUND Plasma amino acid (PAA) levels can be largely normalized during parenteral nutrition (PN) in infants and children using a pediatric-specific amino acid (AA) formulation. However, these previous results were based on individual clinical studies of small populations of neonates and infants. OBJECTIVE We have now examined AA levels in 108 children (0–7 years of age) receiving a pediatric-specific AA formulation in PN using a single analytical methodology. METHODS Infants and children were enrolled in specific protocols and parents/caregivers gave informed consent. Patients wer

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Lonoce, I., C. Maraston, D. Thomas, et al. "Stellar population properties of individual massive early-type galaxies at 1.4 < z < 2." Monthly Notices of the Royal Astronomical Society 492, no. 1 (2019): 326–51. http://dx.doi.org/10.1093/mnras/stz3404.

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ABSTRACT We analyse publicly available, individual spectra of four massive ($M\gt 10^{11}\, \mathrm{M}_{\odot }$) early-type galaxies with redshifts in the range 1.4 ≤ z ≤ 2 to determine their stellar content, extending our previous work up to z ∼ 2. The wide wavelength range of the VLT/X-Shooter spectroscopic data in the UV–Optical–NIR arms along with the availability of spectro-photometry allows us to explore different techniques to obtain the stellar population properties, namely through age/metallicity-sensitive spectral indices, full spectral fitting, and broad-band photometric fitting. M

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Milanese, Manlio, Chiara Mondino, Mariangela Tosca, G. Walter Canonica, and Vito Brusasco. "Modulation of airway caliber by deep inhalation in children." Journal of Applied Physiology 88, no. 4 (2000): 1259–64. http://dx.doi.org/10.1152/jappl.2000.88.4.1259.

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To elucidate whether deep inhalation (DI) modulates changes in airway caliber in childhood, we measured the effect of DI on respiratory impedance before and after inhaled methacholine or salbutamol in 4- to 7-yr-old children ( n = 15) suffering from recurrent wheezing. In all children, the real part of impedance between 12 and 16 Hz (Re[Z]12–16) increased after methacholine from 5.6 ± 1.2 to 8.2 ± 1.6 cmH2O ⋅ l− 1 ⋅ s ( P < 0.001) and resonance frequency from 18 ± 3 to 25 ± 5 Hz ( P < 0.001). These changes were partially reversed by DI: Re[Z]12–16 decreased to 7.2 ± 1.2 cmH2O ⋅ l− 1 ⋅ s

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Ramel, Alfons. "LIVING ALONE IS ASSOCIATED WITH POORER PHYSICAL FUNCTION AND BONE MINERAL DENSITY IN ICELANDIC OLD ADULTS." Innovation in Aging 3, Supplement_1 (2019): S482. http://dx.doi.org/10.1093/geroni/igz038.1793.

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Abstract Background: Loneliness and living alone have been significant public health concerns among older adults given their association with a wide range of adverse health outcomes. Aim: The aim of this study was to examine whether living alone is associated with physical function and bone health in community-dwelling older adults. Methods: This was a secondary analysis of existing cross-sectional data of old adults (N=182, 73.7±5.7yrs, 58.2% female) from the Reykjavik capital area in Iceland. Information on socioeconomics, health, dietary intake and physical function was collected. 25-hydrox

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Lorand, Laszlo, Pauline T. Velasco, S. N. Prasanna Murthy, Phil Lefebvre, and David Green. "Autoimmune Antibody in a Hemorrhagic Patient Interacts With Thrombin-Activated Factor XIII in a Unique Manner." Blood 93, no. 3 (1999): 909–17. http://dx.doi.org/10.1182/blood.v93.3.909.

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Abstract Without a prior history of hemorrhagic disease, a 62-year-old man suffered recurrent episodes of bleeding. Solubility of the patient’s clot in 5 mol/L urea indicated a problem with fibrin stabilization. The transamidase activity potential of factor XIII, measured by the incorporation of radioactive putrescine into N,N-dimethylcasein as test substrate, was 62% of control, close to the normal range of values. Examination of the patient’s clot from recalcified plasma by sodium dodecyl sulfate-polyacrylamide gel electrophoresis showed that essentially none of the  chains and only about t

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Lorand, Laszlo, Pauline T. Velasco, S. N. Prasanna Murthy, Phil Lefebvre, and David Green. "Autoimmune Antibody in a Hemorrhagic Patient Interacts With Thrombin-Activated Factor XIII in a Unique Manner." Blood 93, no. 3 (1999): 909–17. http://dx.doi.org/10.1182/blood.v93.3.909.403k17_909_917.

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Without a prior history of hemorrhagic disease, a 62-year-old man suffered recurrent episodes of bleeding. Solubility of the patient’s clot in 5 mol/L urea indicated a problem with fibrin stabilization. The transamidase activity potential of factor XIII, measured by the incorporation of radioactive putrescine into N,N-dimethylcasein as test substrate, was 62% of control, close to the normal range of values. Examination of the patient’s clot from recalcified plasma by sodium dodecyl sulfate-polyacrylamide gel electrophoresis showed that essentially none of the  chains and only about two thirds

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Taylor, Caroline M., Jean Golding, and Katarzyna Kordas. "Prenatal lead exposure: associations with growth and anthropometry in early childhood in a UK observational birth cohort study." Wellcome Open Research 5 (October 8, 2020): 235. http://dx.doi.org/10.12688/wellcomeopenres.16338.1.

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Background: Lead is a neurotoxic metal that crosses the placenta freely. It has adverse effects on a range of birth outcomes. The few studies reporting on the associations of prenatal exposure to lead and child growth have had conflicting results. This study aimed to examine the effect of low-level prenatal exposure to lead on children’s growth from 4 to 61 months old. Methods: Pregnant women were enrolled in the UK Avon Longitudinal Study of Parents and Children (ALSPAC). Whole blood samples for pregnancies with a live birth were analysed for lead (n=4140). A 10% subsample of the offspring co

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Tishova, Yuliya, and Svetlana Y. Kalinchenko. "Breaking the vicious circle of obesity: the metabolic syndrome and low testosterone by administration of testosterone to a young man with morbid obesity." Arquivos Brasileiros de Endocrinologia & Metabologia 53, no. 8 (2009): 1047–51. http://dx.doi.org/10.1590/s0004-27302009000800021.

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OBJECTIVE: The metabolic syndrome (MS) is associated with low serum testosterone levels. Conversely, low testosterone levels induce MS. These operational mechanisms reinforce one another and induce a vicious cycle. This is a report on a morbid obesity 42 year-old man with the MS and serum testosterone of 5.0 nmol/L (N: 12.0-33.0), who was resistant to treatment with diet and exercise. He was treated with testosterone undecanoate for 16 months. METHODS: Anthropological and laboratory variables were measured before and during testosterone administration. Also the Aging Male Symptom Scale (AMS),

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Puchała, Michał, Józefa Krawczyk, Zofia Sokołowicz, and Katarzyna Utnik-Banaś. "Effect of Breed and Production System on Physicochemical Characteristics of Meat From Multi-Purpose Hens." Annals of Animal Science 15, no. 1 (2015): 247–61. http://dx.doi.org/10.2478/aoas-2014-0082.

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AbstractThe objective of the study was to determine the effect of breed (A) and free-range production system (B) on quality of meat from hens of two breeds, Greenleg Partridge (Z-11) and Rhode Island Red (R-11), which are under the biodiversity conservation programme in Poland. Subjects were 120 hens of each breed, which were assigned to two treatment groups differing in the housing system: 60 layers were kept on litter without outdoor access (C) and 60 layers were raised on litter with access to free range (FR). At 56 weeks of age, 8 hens were randomly chosen from each group, slaughtered, and

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Terriou, Louis, Hanane Gasmi, Salomon Manier, et al. "90-Yttrium Ibritumomab Tiuxetan (Zevalin) and BEAM Chemotherapy (Z-BEAM) Vs BEAM for Autologous Stem Cell Transplantation in Lymphoma: Toxicity and Long Term Outcome From a Retrospective Multicentric Study of 123 Patients." Blood 120, no. 21 (2012): 2726. http://dx.doi.org/10.1182/blood.v120.21.2726.2726.

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Abstract Abstract 2726 Background. There is a need for improving conditioning regimens in poor risk Non Hodgkin Lymphoma (NHL) patients (pts) eligible for autologous stem cell transplantation (ASCT). Incorporating radioimmunotherapy in the conditioning is an option. Bexxar-BEAM does not appear to be superior to BEAM in relapsed Diffuse Large B –cell lymphoma (DLBCL). The benefic risk ratio of 90-yttrium ibritumomab tiuxetan (Zevalin) BEAM remains to be established. Aims and methods. We analyzed retrospectively the efficacy and the toxicity of Zevalin combined with BEAM chemotherapy (Z-BEAM) co

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Raza, A., N. Galili, J. G. Jurcic, et al. "A humanized unconjugated antibody targeting CD33 (SGN-33; huM195) is active in patients with acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS)." Journal of Clinical Oncology 24, no. 18_suppl (2006): 16500. http://dx.doi.org/10.1200/jco.2006.24.18_suppl.16500.

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16500 Background: CD33 is a sialoglycan protein expressed on normal myeloid and monocytic cells as well as the vast majority of myeloid malignancies. A humanized antibody has been developed that recognizes CD33 and induces antibody-dependent cellular cytotoxicity and complement-dependent cytotoxicity. In prior clinical testing, this antibody led to significant reductions in blasts in patients with relapsed and refractory AML. Methods: A phase I single-arm dose escalation trial was initiated at multiple sites to assess the safety, immunogenicity, pharmacokinetics, and activity of SGN-33 at high

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Gorgan, M., Angela Neacsu, Narcisa Bucur, et al. "Brain abscesses: management and outcome analysis in a series of 84 patients during 12 year period." Romanian Neurosurgery 19, no. 3 (2012): 175–82. http://dx.doi.org/10.2478/v10282-012-0008-z.

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Abstract Authors analyze 84 cases of brain abscesses operated between January 2000 and December 2011, in the Fourth Neurosurgical Department by the same surgical team. We underline the general series profile: the mean age was 42.96 years (range: 11-75 years old), 72.62% were males, association with heart defects in seven cases (8.33%), positive bacteriological examination for germs in only 37 cases (44.04%), all negative for HIV infection. The median number of days to diagnosis was 9. Most frequent clinical presentations included headache (40.47%), fever (35.71%), focal neurologic deficits (29

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RAHNEFELD, G. W., R. M. McKAY, G. M. WEISS, et al. "GROWTH AND MATERNAL PERFORMANCE OF TWO-YEAR-OLD F1 AND RECIPROCAL BACKCROSS HEIFERS IN TWO ENVIRONMENTS." Canadian Journal of Animal Science 70, no. 1 (1990): 15–34. http://dx.doi.org/10.4141/cjas90-003.

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Growth patterns and calf performance of 2-yr-old F1 and reciprocal backcross females were compared in two contrasting environments, semi-intensive management (Brandon, Man.) and extensive range management (Manyberries, Alta.). At Brandon, 621 heifers of Hereford × Angus (HA), Simmental × Shorthorn (SN), Charolais × Shorthorn (CN) and reciprocal backcrosses from Charolais × Hereford (CH), Charolais × Angus (CA), Charolais × Shorthorn (CN), Simmental × Hereford (SH), Simmental × Angus (SA), and Simmental × Shorthorn (SN) were evaluated. At Manyberries, 271 heifers of HA, SN, CN and reciprocals o

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Elizagaray-Garcia, Ignacio, Hector Beltran-Alacreu, Santiago Angulo-Díaz, Miriam Garrigós-Pedrón, and Alfonso Gil-Martínez. "Chronic Primary Headache Subjects Have Greater Forward Head Posture than Asymptomatic and Episodic Primary Headache Sufferers: Systematic Review and Meta-analysis." Pain Medicine 21, no. 10 (2020): 2465–80. http://dx.doi.org/10.1093/pm/pnaa235.

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Abstract Objective To summarize the cervical physical examination characteristics in subjects with chronic primary headache and compare those with a healthy population and a population with episodic primary headache. Design Systematic review and meta-analysis. Subjects Humans ≥18 years old. At least one of the study groups should be constituted by subjects diagnosed with one of the chronic primary headache subtypes according to the International Classification of Headache Disorders, 3rd Edition. Comparison Neck physical examination outcomes of subjects with chronic primary headache compared wi

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Christ, G. J., J. Rehman, N. Day, et al. "Intracorporal injection of hSlocDNA in rats produces physiologically relevant alterations in penile function." American Journal of Physiology-Heart and Circulatory Physiology 275, no. 2 (1998): H600—H608. http://dx.doi.org/10.1152/ajpheart.1998.275.2.h600.

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The Ca2+-sensitive K+ channel (maxi-K+) is an important modulator of corporal smooth muscle tone. The goal of these studies was twofold: 1) to determine the feasibility of transfecting corporal smooth muscle cells in vivo with the hSlo cDNA, which encodes for the human smooth muscle maxi-K+channel, and 2) to determine whether transfection of the maxi-K+channel would affect the physiological response to cavernous nerve stimulation in a rat model in vivo. Intracorporal microinjection of pCMVβ/Lac Z DNA in 10-wk-old rats resulted in significant incorporation and expression of β-galactosidase acti

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Babb, Anna, Nadine Farah, Jane Apperley, et al. "Uptake and Outcome of Artificial Reproductive Techniques Following Allogeneic Stem Cell Tranplantation: A Single Centre Experience." Blood 114, no. 22 (2009): 2257. http://dx.doi.org/10.1182/blood.v114.22.2257.2257.

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Abstract Abstract 2257 Poster Board II-234 Introduction: Infertility is common following allogeneic stem cell transplant (allo-SCT). Very little data are available on the use and success of artificial reproductive techniques in patients who have undergone allo-SCT as treatment for cancer. Patients and Methods: We have performed a retrospective survey to assess the uptake of gamete/embryo storage prior to SCT, their use following SCT and the success rate of these techniques. Two hundred patients (95 female) who received allo-SCT between 1979 and 2007 responded to a questionnaire at a median of

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Mehrbani, Solmaz Pourzare, Zohreh Babaloo, Zahra Jamali, Tahmoores Abdollahian, Hosein Eslami, and Narges Sobhani. "Effect of Air Pollution on Salivary Interleukin-8 Levels in Children." World Journal of Dentistry 7, no. 4 (2016): 175–78. http://dx.doi.org/10.5005/jp-journals-10015-1390.

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ABSTRACT Background Air pollution in cities has always been a permanent and serious threat for the health of society and the environment, influencing the health of different body organs and systems both acutely and chronically. Therefore, the aim of this study is to investigate the effect of air pollution in saliva Interleukin-8 (IL-8) levels in children. Materials and methods A total of 88, 8- to 10-year-old children were included in this descriptive cross-sectional study. Group I, the case group, included 44 children from Tabriz (Iranian Azerbaijan), and group II, the control group, included

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Cullen, Breda, Daniel J. Smith, Ian J. Deary, Jill P. Pell, Katherine M. Keyes, and Jonathan J. Evans. "Understanding cognitive impairment in mood disorders: mediation analyses in the UK Biobank cohort." British Journal of Psychiatry 215, no. 5 (2019): 683–90. http://dx.doi.org/10.1192/bjp.2019.188.

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BackgroundCognitive impairment is strongly linked with persistent disability in people with mood disorders, but the factors that explain cognitive impairment in this population are unclear.AimsTo estimate the total effect of (a) bipolar disorder and (b) major depression on cognitive function, and the magnitude of the effect that is explained by potentially modifiable intermediate factors.MethodCross-sectional study using baseline data from the UK Biobank cohort. Participants were categorised as having bipolar disorder (n = 2709), major depression (n = 50 975) or no mood disorder (n = 102 931 a

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Ramadan, Salim, Jim Wilde, Anne Tabard-Fougère, et al. "Cardiopulmonary function in adolescent patients with pectus excavatum or carinatum." BMJ Open Respiratory Research 8, no. 1 (2021): e001020. http://dx.doi.org/10.1136/bmjresp-2021-001020.

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BackgroundPectus excavatum (PE) and pectus carinatum (PC) have generally been considered an aesthetic issue, although there is growing evidence of associated cardiopulmonary function (CPF) impairment, especially in PE patients. The study goal was to determine any correlation between pectus malformations and cardiopulmonary symptoms and function based on systematic assessment of CPF and thoracic measurements, such as Haller Index (HI) and sternal torsion angle (STA).MethodsData from 76 adolescent patients with PE (n=30) or PC (n=46) were retrospectively collected referred between January 2015 a

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Tyminski, N., A. Hudson, J. Turner, and J. Silverman. "A134 RATES OF PARENTERAL NUTRITION-ASSOCIATED CHOLESTASIS/LIVER DISEASE AND GROWTH PRE- AND POST-SMOFLIPID INTRODUCTION IN NEONATES AND INFANTS WITH INTESTINAL FAILURE." Journal of the Canadian Association of Gastroenterology 3, Supplement_1 (2020): 155–56. http://dx.doi.org/10.1093/jcag/gwz047.133.

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Abstract Background Parenteral nutrition (PN) is essential for survival in infants with intestinal failure (IF). PN-associated cholestasis (PNAC) and liver disease (PNALD) are life-threatening complications of long-term PN use. SMOFlipid (soybean oil, medium-chain triglycerides, olive oil, and fish oil) has recently been approved as an off-label alternative to the conventional soy-based lipid emulsion (Intralipid). It is thought to have anti-cholestatic properties due to its more diverse lipid composition. Due to its’ recent approval in Canada (2013) and the USA (2016), data remains sparse. Ai

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Ataallah, Basma, Mustafa Abdulrahman, and Georgia Kulina. "A Case of Rhabdomyolysis in a Patient With Hashimoto’s Thyroiditis." Journal of the Endocrine Society 5, Supplement_1 (2021): A909—A910. http://dx.doi.org/10.1210/jendso/bvab048.1857.

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Abstract Introduction: Hashimoto’s thyroiditis (HT) is an autoimmune disease that presents with musculoskeletal symptoms like proximal muscle weakness, stiffness, pain or cramps in the majority of patients. Rhabdomyolysis which is a breakdown of the skeletal muscles, is a rare but serious manifestation of hypothyroidism and if occurs, it is usually related to trauma, strenuous exercise or use of statins. We report a patient with unrecognized Hashimoto’s thyroiditis who presented with severe rhabdomyolysis without reported history of strenuous exercise, seizures or statin use and surprisingly,

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Li, Jingyu, Linlin Cui, Xiao Jiang, et al. "Transmission of polycystic ovary syndrome susceptibility single-nucleotide polymorphisms and their association with phenotype changes in offspring." Human Reproduction 35, no. 7 (2020): 1711–18. http://dx.doi.org/10.1093/humrep/deaa125.

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Abstract STUDY QUESTION Does the inheritance of polycystic ovary syndrome (PCOS) susceptibility single-nucleotide polymorphism affect the phenotype of offspring? SUMMARY ANSWER Male offspring who inherit PCOS-related genetic variations from PCOS mothers were more susceptible to developing the metabolic abnormality in their later life. WHAT IS KNOWN ALREADY Genetic factors are considered the major etiology of PCOS. Previous studies have highlighted that offspring of women with PCOS had an increased risk of the same disease or PCOS-like symptoms. STUDY DESIGN, SIZE, DURATION The study involved 1

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Bennett, Dorothy E., Ruba Riachy, Lucas S. Blanton, and L. Maria Belalcazar. "Hypercalcemia: A Metabolic Complication of an AIDS-Defining Illness." Journal of the Endocrine Society 5, Supplement_1 (2021): A198—A199. http://dx.doi.org/10.1210/jendso/bvab048.403.

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Abstract Background: Hypercalcemia may result from the activation of macrophages in granulomatous diseases with increased production of 1,25 dihydroxyvitamin D/calcitriol. Its occurrence in patients with human immunodeficiency virus-1 (HIV-1) infection may be atypical and signal major changes in immune status. We report on a patient with acquired immunodeficiency syndrome (AIDS) presenting with new-onset hypercalcemia after months of treatment for mycobacterium avium complex (MAC) infection and normal calcitriol levels. Clinical Case: A 37-year-old man on treatment for HIV-1 and disseminated M

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Russo, Filippo, Gaetano Corazzelli, Secondo Lastoria, et al. "Dose-Dense(dd) ABVD and Dose-Dense/Dose-Intense(dd-di) ABVD in Newly Diagnosed Patients (pts), Intermediate- and Advanced-Stage with Classical Hodgkin's Lymphoma (cHL): Final Results." Blood 114, no. 22 (2009): 715. http://dx.doi.org/10.1182/blood.v114.22.715.715.

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Abstract Abstract 715 We previously reported interim results (Blood-ASH Annual Meeting Abstracts-2007 110: abstract 2324) of a prospective study evaluating dose-dense and dose-intense variants of ABVD regimen. Seventy pts with a newly diagnosis of cHL were enrolled from 06/04 to 03/08. Pts had intermediate-(INT) or advanced-stage (ADV) according to GHLSG criteria (Tab.1). INT (n=24) were treated with dd ABVD, and ADV (n=46) with dd-di ABVD. Briefly, the strategy concepts of treatment were: 6 cycles of chemotherapy; the inter-cycle period shortened from 28 to 21 days; drugs delivered at day 1 a

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Stephens, Deborah M., Alexander N. Starodub, John C. Byrd, et al. "Subcutaneous Injections of IMMU-114 (Anti-HLA-DR IgG4 Monoclonal Antibody): Initial Results of a Phase I First-in-Man Study in Hematologic Malignancies." Blood 126, no. 23 (2015): 2740. http://dx.doi.org/10.1182/blood.v126.23.2740.2740.

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Abstract Introduction. HLA-DR is expressed in non-Hodgkin lymphoma (NHL), chronic lymphocytic leukemia (CLL), and other B-cell malignancies at significantly higher levels than typical B-cell markers, including CD20. Prior attempts to develop anti-HLA-DR antibodies in this population have been hampered by toxicity, notably infusion-related toxicities (Lin et al, Leuk Lymphoma, 2009). In preclinical studies, a novel anti-HLA-DR IgG4 antibody, L243, was consistently more cytotoxic than rituximab in the cell lines studied, with minimal CDC and ADCC, but activating internal signaling and inducing a

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Swords, Ronan T., Harry P. Erba, Daniel J. DeAngelo, et al. "The Novel, Investigational NEDD8-Activating Enzyme Inhibitor MLN4924 In Adult Patients with Acute Myeloid Leukemia (AML) or High-Grade Myelodysplastic Syndromes (MDS): A Phase 1 Study." Blood 116, no. 21 (2010): 658. http://dx.doi.org/10.1182/blood.v116.21.658.658.

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Abstract Abstract 658 Background: NEDD8-activating enzyme (NAE) regulates the NEDD8 conjugation pathway, and is required for the activity of the cullin-RING E3 ligases (CRLs). CRLs control the timed degradation of several substrates involved in cell-cycle regulation, signal transduction, DNA replication, and stress response, including proteins important for the survival of AML cells. We evaluated the preclinical anti-leukemic activity of MLN4924, a novel, investigational, first-in-class small molecule inhibitor of NAE, and based on the activity of MLN4924 in preclinical AML models (Swords RT e

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Radhakrishnan, Neetu, and Mark A. Hoffman. "Hypercalcemia in B-Cell Chronic Lymphocytic Leukemia: Report of a Case and Review of the Literature." Blood 106, no. 11 (2005): 5009. http://dx.doi.org/10.1182/blood.v106.11.5009.5009.

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Abstract A 53 year old man with Rai stage IV CLL was being treated with R-HyperCVAD when he presented between cycles with fatigue, lethargy and pancytopenia. Clinical examination revealed diffuse adenopathy and splenomegaly. Serum calcium was 13.6 mg/dl, phosphorus level was 2.7 mg/dl, and alkaline phosphatase was 54 U/L. PTH was 4 Units/L (10–65), PTHrP &lt; 0.2 pmole/L (0–1.9), 1–25 (OH) Vitamin D &lt; 10pgm/ml (22–67). Quantitative immunglobulins: IgA 10 mg/dl, IgG 252 mg/dl, IgM 50 mg/dl. Immunofixation revealed a faint IgG lambda paraprotein. There were no lytic lesions on skeleta

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Fröhling, Stefan, Mridul Agrawal, Nikolaus Jahn, et al. "CDK4/6 Inhibitor Palbociclib for Treatment of KMT2A-Rearranged Acute Myeloid Leukemia: Interim Analysis of the AMLSG 23-14 Trial." Blood 128, no. 22 (2016): 1608. http://dx.doi.org/10.1182/blood.v128.22.1608.1608.

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Abstract Background: Approximately 5% of adult acute myeloid leukemia (AML) cases are associated with balanced translocations of chromosome 11q23, and AML with t(9;11)(p22;q23) is recognized as a distinct entity by the WHO Classification. Similarly, the presence of t(4;11)(q21;q23), which accounts for 8-10% of B-cell precursor acute lymphoblastic leukemia (ALL) in patients over the age of 20 years, defines a distinct entity termed "B-lymphoblastic leukemia with t(v;11q23)" according to the WHO Classification. On the molecular level, t(11q23) result in fusion of the KMT2A (also called MLL) gene

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Suttorp, Meinolf, Ralf Knoefler, Hélène Deutsch, et al. "High Platelet Counts, Thrombosis, Bleeding Signs, and Acquired Von Willebrand Syndrome at Diagnosis of Pediatric Chronic Myeloid Leukemia." Blood 134, Supplement_1 (2019): 4152. http://dx.doi.org/10.1182/blood-2019-123343.

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Background: At diagnosis of chronic myeloid leukemia (CML) patients (pats) may present with elevated platelets (PLT) counts. Generally, high PLT counts may result in thrombosis and/or bleeding complications, the latter being due to binding of von Willebrand factor (VWF) multimers to platelets. Pediatric CML is very rare (Hijiya N, Suttorp M 2019; Blood 33:2374-2384) and no systematic investigation on clinical complications of elevated PLT counts has so far been reported. Methods: Data on PLT counts and associated thrombo-hemorrhagic complications were retrospectively analyzed in newly diagnose

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Ulmer, Anna, Josephine Tabea Tauer, and Meinolf Suttorp. "Impact of Treatment with Tyrosine Kinase Inhibitors (TKIs) On Blood Levels of Growth Hormone-Related Parameters, Testosterone, and Inhibin B in Juvenile Rats and Pediatric Patients with Chronic Myeloid Leukemia (CML)." Blood 120, no. 21 (2012): 3752. http://dx.doi.org/10.1182/blood.v120.21.3752.3752.

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Abstract Abstract 3752 Background: Long-term treatment with TKIs is of special concern in pediatric patients (pts) with CML as these drugs -beside their specific inhibition of the BCR-ABL oncogene- exert multiple off-target effects. Among these the precise influence on the longitudinal growth and the reproductive endocrine system –being of particular interest in growing organisms– is still not clarified. We therefore investigated in blood serum the growth hormone-related parameter insulin-like growth factor-binding protein 3 (IGFBP3) as well as testosterone (Testo) and inhibin B (InB) in an an

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Taguchi, Tomomi, Takuya Toki, Akinori Hayashi, and Koji Takano. "A Case With Adult GH Deficiency Complicated With Osteogenesis Imperfecta: Effect of GH Replacement on Bone Mineral Density." Journal of the Endocrine Society 5, Supplement_1 (2021): A564. http://dx.doi.org/10.1210/jendso/bvab048.1149.

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Abstract Background: Osteogenesis imperfecta (OI) is an inherited connective tissue disorder with many phenotypic presentations. Bisphosphonates are the mainstay of pharmacologic fracture prevention therapy, although they aren’t officially approved for the treatment of OI. Clinical Case: The patient was born by breech delivery. After he had multiple fractures at the age of two years, he was diagnosed with osteogenesis imperfecta (OI) type I by genetic analysis (c.1299 + 1G&gt; A mutation in the COL1A1 gene). On the growth curve, his height fell below -2SD at the age of six years. When he w

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Deguchi, Hiroshi, Sunia Trauger, Ewa Kalisiak, et al. "Warfarin Untargeted Metabolomics Study Identifies Novel Procoagulant Ethanolamide Lipids." Blood 118, no. 21 (2011): 1200. http://dx.doi.org/10.1182/blood.v118.21.1200.1200.

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Abstract Abstract 1200 Untargeted metabolomics denotes the profiling of several thousand low molecular weight biochemicals, including lipids, hormones, saccharides, nucleotides, organic acids, and amino acids. The analytes are measured using mass spectrometry (MS) as molecule mass peaks without specific “targeting” of specific metabolites or analytes. We undertook an untargeted metabolomics investigation to define the effect of warfarin on plasma metabolite profiles in a crossover study of 17 venous thrombosis patients (9 male, 8 female) (age 58.1 ± 18.6 yr old; range 27–83 yr old). Blood was

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Boily, Pascale, Nicole van Rossum, Marco Lefebvre, and Matthieu St-Jean. "Adrenoleukodystrophy and Secondary Hyperaldosteronism; A Clinical Demonstration of the Zona Glomerulosa Persistence." Journal of the Endocrine Society 5, Supplement_1 (2021): A112—A113. http://dx.doi.org/10.1210/jendso/bvab048.226.

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Abstract Adrenoleukodystrophy (ALD) is a peroxisomal disorder which leads to the accumulation of very long-chain fatty acids in all tissues. Age at onset of symptoms vary depending on the phenotype severity. It can present with progressive symptoms of neurological defects and/or primary adrenal insufficiency. We report a case of 31 yo man diagnosed in childhood with ALD and treated with hydrocortisone and fludrocortisone who eventually developed resistant hypertension due to secondary hyperaldosteronism. He was diagnosed with ALD at 9-year-old and have received an allogenic hematopoietic cell

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Zea-Bonilla, T., M. A. González-Sánchez, P. M. Martín-Sánchez, and R. M. Pérez-Jiménez. "Avocado Dieback Caused by Neofusicoccum parvum in the Andalucia Region, Spain." Plant Disease 91, no. 8 (2007): 1052. http://dx.doi.org/10.1094/pdis-91-8-1052b.

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From 2002 to 2006, adult avocado trees, Persea americana Miller cv. Hass, located in the subtropical-fruit-producing area of Andalucia (southern Spain) developed symptoms of dieback characterized by death of twigs and branches in the tree canopy. Sections of surface-disinfested, necrotic branch tissues were plated on Difco potato dextrose agar (PDA) (Sparks, NV) and a Neofusicoccum-like fungus was isolated. On PDA, the isolates had white, appressed mycelium that turned dull gray as the colony aged, although conidia were not formed. Abundant pycnidia and conidia developed when isolates were cul

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Baba, Rozita, Zulkefly Abdul Karim, Mariani Abdul-Majid, and Noorasiah Sulaiman. "TECHNICAL EFFICIENCY OF SECONDARY SCHOOLS IN MALAYSIA." Journal of Nusantara Studies (JONUS) 6, no. 1 (2021): 265–83. http://dx.doi.org/10.24200/jonus.vol6iss1pp265-283.

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Background and Purpose: The purpose of this study is to investigate the level of technical efficiency of Malaysia’s secondary education. Education efficiency has become an important issue since the education sector is the recipient of high priority budget allocation. An evaluation of whether the budget distribution for secondary education is technically efficient is necessary because secondary education represents almost 40% of the national education budget.   Methodology: The study applied the Data Envelopment Analysis (DEA) in examining the level of technical efficiency for a sam

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Katz-Jaffe, M. G., C. Sheehan, W. B. Schoolcraft, and D. K. Gardner. "330 THE PROTEIN EXPRESSION PROFILE (SECRETOME) OF INDIVIDUAL CUMULUS - OOCYTE COMPLEXES DURING IVM IN THE MOUSE IS AFFECTED BY FSH." Reproduction, Fertility and Development 18, no. 2 (2006): 272. http://dx.doi.org/10.1071/rdv18n2ab330.

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Studies of the protein expression profile into the surrounding medium (secretome) of in vitro-matured cumulus-oocyte complexes (COCs) have the potential to elucidate biochemical pathways involved in oogenesis, including the complex dialogue between the oocyte and its supporting cells. The understanding of these processes should assist in improving IVM success and fertility outcome, as early embryo development reflects the quality of the oocyte and its cumulus cells. Through the analysis of the individual COC secretome, we have investigated the effects of adding follicle stimulating hormone (FS

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Cardin, L., and B. Moury. "First Report of Alfalfa mosaic virus on Rhamnus alaternus in France." Plant Disease 90, no. 8 (2006): 1115. http://dx.doi.org/10.1094/pd-90-1115c.

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Rhamnus alaternus L. (evergreen buckthorn), family Rhamnaceae, is a small, hardy shrub from Mediterranean regions grown for its ornamental persistent green or variegated foliage. Chlorotic oak leaf or ringspot symptoms on R. alaternus leaves have been observed in southern France (Bellegarde, Gard department in 1998; Fanjaux, Aude department in 2000; and Saint-Jean-Cap-Ferrat, Alpes-Maritimes department in 2002). Samples from these three localities revealed the presence of Alfalfa mosaic virus (AMV) due to (i) the symptoms observed in an inoculated diagnostic host range previously described (1)

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Galhardo, Júlia, and Julian Shield. "O Papel da Hemoglobina A1c no Rastreio de Intolerância à Glicose e da Diabetes Tipo 2 em Crianças e Adolescentes Obesos." Acta Médica Portuguesa 28, no. 3 (2015): 307. http://dx.doi.org/10.20344/amp.5494.

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<strong>Introduction:</strong> In 2012, an international expert committee in diabetes wrote in favor of screening adult and paediatric patients for glucose intolerance and type 2 diabetes using glycated haemoglobin. The aim of this study was to evaluate glycated haemoglobin utility as a screening tool in a young obese mainly Caucasian population.<br /><strong>Material and Methods:</strong> Children [(n = 266), body mass index z-score 3.35 ± 0.59, 90% Caucasian 90%, 55% female, median age 12.3 (range: 8.9 - 17.6) years old] recently referred to a tertiary hospital-

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44

Bliznashka, Lilia, Ifeyinwa E. Udo, Christopher R. Sudfeld, Wafaie W. Fawzi, and Aisha K. Yousafzai. "Associations between women’s empowerment and child development, growth, and nurturing care practices in sub-Saharan Africa: A cross-sectional analysis of demographic and health survey data." PLOS Medicine 18, no. 9 (2021): e1003781. http://dx.doi.org/10.1371/journal.pmed.1003781.

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Background Approximately 40% of children 3 to 4 years of age in low- and middle-income countries have suboptimal development and growth. Women’s empowerment may help provide inputs of nurturing care for early development and growth by building caregiver capacity and family support. We examined the associations between women’s empowerment and child development, growth, early learning, and nutrition in sub-Saharan Africa (SSA). Methods and findings We pooled data on married women (15 to 49 years) and their children (36 to 59 months) from Demographic and Health Surveys that collected data on chil

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Caesar, A. J., R. T. Lartey, and T. Caesar-TonThat. "First Report of Anthracnose Stem Canker of the Invasive Perennial Weed Lepidium draba Caused by Colletotrichum higginsianum in Europe." Plant Disease 94, no. 9 (2010): 1166. http://dx.doi.org/10.1094/pdis-94-9-1166c.

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Exotic perennial Lepidium draba, native to Eurasia, is an invasive weed in dense stands in rangelands and disturbed areas in several states of the western United States and an agricultural weed in the prairie provinces of Canada. To determine strategies, such as a potential multipathogen strategy (1), for biological control of the weed, surveys that included the native range were conducted in spring 2009 to detect diseases that occur on this weed. Several stunted and chlorotic plants were found scattered throughout a stand of L. draba growing in a vacant lot near Riddes, Switzerland (46°08′22.

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Rezazadeh, Arash, Sandra C. Hollensead, Damian A. Laber, and Goetz H. Kloecker. "Intracranial Hemorrhage in a Patient with Osteogenesis Imperfecta Due to Inherited and Acquired Platelet Dysfunction." Blood 108, no. 11 (2006): 3960. http://dx.doi.org/10.1182/blood.v108.11.3960.3960.

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Abstract A 42 year-old man with Osteogenesis Imperfecta (OI) had three episodes of spontaneous Subdural Hematoma (SH) after binge drinking. There is no remote history of abnormal bleeding or easy bruising despite multiple fractures. Medications included Aspirin (ASA). The first and second SH occurred within the preceding year and were treated conservatively. The third SH occurred while on ASA and drinking more than 500cc liquor/day. The Platelet Function Assay (PFA-100) was significantly abnormal (see table). After platelet transfusions the SH was surgically evacuated without complications. An

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Badawi, Maha A., Linda M. Vickars, Jocelyn M. Chase, and Heather A. Leitch. "Red Blood Cell Transfusion Independence Following the Initiation of Iron Chelation Therapy in Myelodysplastic Syndrome." Blood 114, no. 22 (2009): 4844. http://dx.doi.org/10.1182/blood.v114.22.4844.4844.

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Abstract Abstract 4844 Background Iron chelation therapy (ICT) is often used to treat iron overload (IOL) in patients (pts) requiring transfusion of red blood cells (RBC) for chronic anemia. In myelodysplastic syndrome (MDS), guidelines recommend consideration of ICT in pts with lower risk International Prognostic Scoring System (IPSS) and IOL as defined by a ferritin level >1000 ug/l; IOL related organ dysfunction; or receipt of ≥20 RBC units. During treatment of a pt with MDS and IOL with ICT, RBC transfusion requirement (TR) ceased. Here we report his course and review reported cases of

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Gunes, Adalet Meral, Frédéric Millot, Krzysztof Kalwak, et al. "Features and Outcome of Chronic Myeloid Leukemia (CML) at Very Young Age: Data from the International Pediatric CML Registry (I-CML-Ped Study)." Blood 132, Supplement 1 (2018): 1748. http://dx.doi.org/10.1182/blood-2018-99-112905.

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Abstract Introduction: CML is rare in the first two decades of life comprising only 3% of pediatric and adolescent leukemias. The overall annual incidence is approximately 1 per million children and adolescents and it increases with age (median: 12 yrs, range: 1-18) resulting in an extreme rarity of children affected in the first years of life. Data regarding the clinicopathologic characteristics and response to therapy of childhood CML diagnosed at age <3 years has not been reported yet. Aims and objectives: We studied the epidemiologic and clinical features of patients(pts) with CML <3

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Intini, M., A. Panconesi, M. L. Ben Jamâa, G. Stanosz, and D. Smith. "First Report of Diplodia Canker of Cypress Caused by Diplodia pinea f. sp. cupressi on Mediterranean Cypress in Tunisia." Plant Disease 89, no. 11 (2005): 1246. http://dx.doi.org/10.1094/pd-89-1246a.

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Symptoms of decline were observed on Mediterranean cypress trees (Cupressus sempervirens L.) in Tunisia in 2003 and 2004; disease specimens were vouchered as FIAF 38649. The declining, windbreak trees in the Cap Bon Region were 25 to 30 years old. Severity of symptoms varied among trees. Thus, areas of reddish, withered foliage alternated with areas that were still green. Other trees were completely withered. The bases of withered branches and tree trunks bore slightly sunken cankers with longitudinal bark cracks that oozed drops of resin. When the outer layer of a cankered area was scraped aw

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Ding, Z., J. Namphueng, X. F. He, D. L. Peng, and W. K. Huang. "First Report of the Cyst Nematode (Heterodera elachista) on Rice in Hunan Province, China." Plant Disease 96, no. 1 (2012): 151. http://dx.doi.org/10.1094/pdis-07-11-0576.

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During a survey for the cyst nematodes (Heterodera elachista) from May to June of 2011, cyst nematodes were detected in hilly rice fields in five counties (Changsha, Pingjiang, Hengdong, Shaoyang, and Xiangxiang) of Hunan Province, China. Cyst nematodes obtained from soil samples and harvested rice root samples at these five locations had uniform morphological and molecular characteristics. Cysts (n = 20) had the following characteristics: spherical to lemon shaped, vulval cone ambifenestrate, vulval bridge narrow, medium sized underbridge, with a few dark brown bullae, body length (not includ

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