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1
Santoalla, Ed L. Lessons in ODA: Theory and practice. Diliman, Quezon City, Philippines: Management and Orgnizational Development for Empowerment, 2001.
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2
Robin, Morgan. The word ofa woman: Feminist dispatches 1968-1992. New York: W.W. Norton, 1992.
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3
Ubezhishta na vi︠a︡rata: T︠s︡ŭrkvata i sŭborŭt v sŭchinenii︠a︡ta na Marsilio ot Padua i Uili︠a︡m ot Okam. Sofii︠a︡: Universitetsko izdatelstvo "Sv. Kliment Okhridski", 2010.
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4
Woolf, Virginia. Kendine ait bir oda. Istanbul: Afa, 1988.
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5
Schellhammer. The last aristocrats: The cutlers of Solingen and Sheffield in the nineteenth century and the theory ofa labor aristocracy. Ann Arbor: UMI, 1994.
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6
Ohsawa, Takeo. L² Approaches in Several Complex Variables: Towards the Oka-Cartan Theory with Precise Bounds. Springer, 2019.
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7
Ohsawa, Takeo. L² Approaches in Several Complex Variables: Towards the Oka–Cartan Theory with Precise Bounds. Springer, 2018.
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8
Ohsawa, Takeo. L² Approaches in Several Complex Variables: Development of Oka-Cartan Theory by L² Estimates for the d-bar Operator. Springer, 2015.
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9
Ohsawa, Takeo. L² Approaches in Several Complex Variables: Development of Oka-Cartan Theory by l² Estimates for the d-Bar Operator. Springer, 2015.
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10
Ohsawa, Takeo. L² Approaches in Several Complex Variables: Development of Oka–Cartan Theory by L² Estimates for the d-bar Operator. Springer, 2016.
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11
Dyken, Mark Eric, Kyoung Bin Im, George B. Richerson, and Deborah C. Lin-Dyken. Sleep and stroke. Edited by Sudhansu Chokroverty, Luigi Ferini-Strambi, and Christopher Kennard. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199682003.003.0027.
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The study of stroke and sleep is in its infancy, as exemplified by the fact that polysomnography (PSG) has only recently been used to help confirm that obstructive sleep apnea (OSA) is a stroke risk factor. There is a strong association between stroke and sleep problems, as stroke can cause, and also may result from, some sleep disorders. Symptoms of OSA, the most frequent and dangerous sleep problem associated with stroke, often suggest other primary sleep disorders. OSA should be the first concern, and, if diagnosed, positive airway pressure (PAP) and positional therapies are first-line treatments. If OSA is ruled out, good sleep hygiene through cognitive–behavioral techniques (cognitive, sleep restriction, stimulus control, and progressive relaxation therapies) are often recommended, as stroke patients are prone to the adverse effects of medications routinely used for sleep problems.
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Randerath, Winfried J., and Shahrokh Javaheri. Sleep and the heart. Edited by Sudhansu Chokroverty, Luigi Ferini-Strambi, and Christopher Kennard. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199682003.003.0040.
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Heart function and sleep are closely associated. While NREM sleep reduces cardiac workload, phasic REM sleep increases sympathetic activity and cardiac vulnerability. Heart failure (HF) patients suffer from disturbed sleep due to frequent awakenings, periodic limb movements, sleep apnea, and depression. Insomnia seems to be associated with incident HF, and, when comorbid, results in a vicious circle. There is much evidence of a relationship between breathing disturbances during sleep and heart diseases. At least 50% of HF patients suffer from obstructive (OSA) or central (CSA) sleep apnea, both associated with impaired prognosis. OSA is a risk factor for arterial hypertension, atrial fibrillation, and HF. Continuous positive airway pressure devices reduce adverse cardiac events and improve outcome in severe OSA in compliant subjects. Adaptive servoventilation (ASV) is superior to other therapeutic options for CSA. However, the use of ASV is contraindicated in severe HF with reduced, but not preserved, ejection fraction.
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Kolsdorf, Juliane, and Ulrich Müller, eds. Transforming International Cooperation. Nomos Verlagsgesellschaft mbH & Co. KG, 2020. http://dx.doi.org/10.5771/9783748908388.
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The world of international cooperation is in transition. Global power shifts and the rise of populism have made the world multipolar, but not necessarily more multilateral. The traditional North–South aid system is being called into question, while transnational challenges are affecting all countries and require stronger global partnerships. In this context, the graduation of countries from Official Development Assistance (ODA) stands out as a focal topic in connecting current debates. Facilitated by the Deutsche Gesellschaft für Internationale Zusammenarbeit (GIZ), this publication sees experts from various sectors and regions share and exchange their views in open dialogues and spotlight texts. They embed ODA graduation in its broader global context, discuss its implications and call for a new partnership based on global goals and knowledge sharing. This collection of thoughts and perspectives will thus hopefully serve as a milestone in the debate on transforming international cooperation.
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Doherty, Michael, Johannes Bijlsma, Nigel Arden, David J. Hunter, and Nicola Dalbeth. Introduction: the comprehensive approach. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199668847.003.0020.
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This introductory chapter to the section on management of osteoarthritis (OA) emphasizes the need for a full assessment of the patient, not just in terms of joint symptoms and examination findings but a full holistic assessment of the person, including the impact of OA on their life, their illness perceptions of OA, and the presence of comorbidities. An individualized package of care can then be developed. Patients should be fully informed about OA and fully involved in all management decisions. Apart from education, which is an ongoing not one-off process, other core treatments to be considered in every person with OA are exercise (both strengthening and aerobic) and strategies to reduce adverse mechanical factors, including weight loss if overweight or obese. Topical non-steroidal anti-inflammatory drugs are the safest analgesic drug to try first for peripheral joint OA. Other treatments can be selected as required from a wide range of drug and non-pharmacological options, to address the needs of the individual. The patient requires regular follow-up for reassessment and re-adjustment of management as required. Currently there are sparse data on predictors of response to treatment, limiting a stratified medicine approach. Caveats to the research evidence for OA and its transition to clinical practice are discussed, and one way of improving this (reporting overall treatment effect and the proportion attributable to placebo in clinical trials) is presented. Optimizing contextual effects, which are an integral part of any treatment and which may explain the majority of improvement that a patient experiences for their OA, is emphasized as a key aspect of care.
15
Demir, Abdullah, ed. Türkiye Sosyal Bilimler Sempozyumu – 2021: Bildiri Özetleri Kitabı. Oku Okut Yayınları, 2021. http://dx.doi.org/10.55709/okuokutyayinlari.8.
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Turkish Symposium of Social Sciences – 2021: The Book of Abstracts. Oku Okut Academy organizes the Turkish Symposium of Social Sciences to bring together professionals who continue their research in the field of Social Sciences and graduate students who continue their education in the field to enable the transfer of experience and strengthen interdisciplinary studies, and contribute to the academic output. Applications to the symposium may be submitted in the fields of Archeology, Anthropology, Literature, Education, Philosophy, Philology, Law, Economics, Theology, Communication, Business, Architecture, Psychology, Art, Political Science, Social Work, Sociology, History, and International Relations. Applications are reviewed by the Symposium Scientific Committee and subjected to the evaluation of at least two referees. The summaries and full texts of accepted papers are brought to the readers by Oku Okut Publications as open access. This book contains the abstracts presented at the Turkish Symposium of Social Sciences held on August 28, 2021.
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Doherty, Michael, Johannes Bijlsma, Nigel Arden, David J. Hunter, and Nicola Dalbeth. Introduction: what is osteoarthritis? Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199668847.003.0001.
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This brief introductory chapter summarizes some of the key clinical and structural features of osteoarthritis (OA) and highlights some general observations and concepts concerning the nature of OA. General observations include the preservation of OA throughout human evolution; the occurrence of OA in many other animals; the dynamic, metabolically active nature of OA pathophysiology; the fact that most OA never associates with symptoms or functional impairment; and the good outcome in many cases of symptomatic OA. Such observations support the concept of OA as the inherent repair process of synovial joints, which can be triggered by a range of diverse insults and in which all the joint tissues are involved. Aetiologically, OA is a common complex disorder with recognized genetic, constitutional, and environmental risk factors, and these may combine in multiple ways to cause marked variation in phenotypic presentation and in some instances ‘joint failure’ with associated symptoms and disability. Within the spectrum of OA are some discrete subsets, the best defined being nodal generalized OA. However, in many people OA does not fit neatly into one type and its phenotypic characteristics may change as it evolves. Two striking associations of OA are with ageing and with crystal deposition, especially calcium crystals but also urate crystals, and there are a number of possible mechanisms to explain these.
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MacGregor, Alex, Ana Valdes, and Frances M. K. Williams. Genetics of osteoarthritis. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199642489.003.0044.
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In this chapter we outline the approaches which have been adopted to identify genetic variants predisposing to osteoarthritis (OA), a condition long recognized as having a heritable component. Such routes to their identification include examining mendelian traits in which OA is a feature, candidate gene studies based on knowledge of OA pathobiology, linkage analysis in related individuals, and, more recently, genome-wide association studies in large samples of unrelated individuals. It is increasingly evident that the main symptom deriving from OA—notably joint pain—also has a genetic basis but this is differs from that underlying OA. Variants convincingly shown to predispose to OA lie in the GDF5 and MCF2L genes and in the chr7 cluster mapping to the COG5 gene, in addition to the ASPN gene in Asian populations. Those associated with pain in OA include TRPV1 and PACE4. Epigenetic influences are also being explored in both the pathogenesis of OA and the variation of pain processing.
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Bannwarth, Bernard, and Francis Berenbaum. Systemic analgesics (including paracetamol and opioids). Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199668847.003.0029.
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Apart from non-steroidal anti-inflammatory drugs (NSAIDs), there are only two categories of systemic analgesics, namely paracetamol (acetaminophen) and opioids, that are currently available worldwide for clinical use. Paracetamol is poorly effective in relieving pain and improving function in patients with symptomatic osteoarthritis (OA). Furthermore, its safety profile is less favourable than classically thought. In fact, there is evidence paracetamol acts as a weak inhibitor of the cyclooxygenase enzymes. Given that paracetamol poses a lower risk of severe adverse events than NSAIDs while being better tolerated than opioids, it is usually considered as the first-line systemic analgesic for OA. Commonly prescribed opioids are primarily agonists of the mu receptors, thereby producing similar desirable (analgesia) and untoward effects. Meta-analyses of short-term clinical trials showed that, on average, the modest clinical benefits of opioids did not outweigh the side effects in patients with knee or hip OA. Accordingly, most current guidelines support the use of opioids for selected OA patients only (e.g. patients who have not had an adequate response to other treatment modalities and are not candidates for total joint arthroplasty). In view of the limited efficacy and/or potential harms of available analgesics, particular attention was paid to novel painkillers, especially nerve growth factor (NGF) antagonists. Although these agents provided clinically meaningful improvements in pain and physical function in patients with hip or knee OA, they lead to severe side effects, including rapidly destructive arthropathies and neuropathies. Thus, if approved for marketing, NGF antagonists would be reserved for selected and well-defined patients with OA.
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Arden, Nigel, and Michael C. Nevitt. Epidemiology. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199668847.003.0008.
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Despite the impact of osteoarthritis (OA) on patients and the health service, OA remains an elusive condition to define and treat. Traditionally, OA has been diagnosed using radiographs and more recently magnetic resonance imaging; however, the last 20 years of research have changed our thinking about the disease and its treatment. We know today that OA takes up to 10–15 years to develop, has a range of risk factors, and that there is a considerable discordance between symptoms and structural signs, such that new classifications and definitions are moving away from structural criteria to combined structure and pain definitions. This chapter reviews the definition and classification of OA and its prevalence, incidence, and natural history.
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Deveza, Leticia A., Changhai Ding, Xingzhong Jin, Xia Wang, Zhaohua Zhu, and David J. Hunter. Laboratory tests. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199668847.003.0019.
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In clinical practice, laboratory tests play a major role in the investigation of underlying diseases predisposing to osteoarthritis (OA) (e.g. metabolic and genetic causes) and in the differential diagnosis of other joint disorders, particularly autoimmune and crystal-related arthropathies. In terms of diagnosis and management of OA, there is still no recommendation in guidelines for the use of laboratory tests. However, an increasing number of potential applications of laboratory tests in OA are emerging. In this regard, research investigating the role of vitamin D and other substances such as inflammatory markers, cytokines, and adipokines in the OA process is helping to reveal novel pathophysiologic mechanisms and, consequently, new possible therapeutic approaches. Furthermore, biochemical markers of cartilage, bone, and synovium metabolism is a growing field in OA and may also contribute to the diagnosis of early OA stages, assessment of prognosis, and management, once properly validated.
21
Kartomi, Margaret. South Sumatra. University of Illinois Press, 2017. http://dx.doi.org/10.5406/illinois/9780252036712.003.0007.
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This chapter examines the historical distribution of two musico-lingual groups living in South Sumatra: the Besemah in Tanjungsakti and Kayuagung, and the Ogan-Komering Ilir (OKI) people in Burai. South Sumatra's network of rivers and tributaries—known as the Batang Hari Sembilan—has governed its peoples' travels, worldviews, adat, legends, and musical arts for well over 2,000 years. This chapter explores how South Sumatra's environment and associated cosmology, adat customs, and the history of religion and foreign contact have shaped its musico-lingual groups and music, dance, and theater more generally. It first considers the Besemah's bardic legends and their classical and social dances and ensemble music, vocal music, and solo instrumental music before turning to the Anak Dalem people. It also describes the Ogan-Komering Ilir (OKI) river basins, the dance called tari tanggai, Palembang, and musical arts with a Muslim theme or flavor in the uplands and lowlands.
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Pevernagie, Dirk. Positive airway pressure therapy. Edited by Sudhansu Chokroverty, Luigi Ferini-Strambi, and Christopher Kennard. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199682003.003.0017.
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This chapter describes positive airway pressure (PAP) therapy for sleep disordered breathing. Continuous PAP (CPAP) acts as a mechanical splint on the upper airway and is the treatment of choice for moderate to severe obstructive sleep apnea (OSA). Autotitrating CPAP may be used when the pressure demand for stabilizing the upper airway is quite variable. In other cases, fixed CPAP is sufficient. There is robust evidence that CPAP reduces the symptomatic burden and risk of cardiovascular comorbidity in patients with moderate to severe OSA. Bilevel PAP is indicated for treatment of respiratory diseases characterized by chronic alveolar hypoventilation, which typically deteriorates during sleep. Adaptive servo-ventilation is a mode of bilevel PAP used to treat Cheyne–Stokes respiration with central sleep apnea . It is crucial that caregivers help patients get used to and be compliant with PAP therapy. Education, support, and resolution of adverse effects are mandatory for therapeutic success.
23
Walsh, David A. Contextual aspects of pain: why does the patient hurt? Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199668847.003.0014.
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The context in which osteoarthritis (OA) pain is experienced moderates and, to an extent, mediates its severity and impact. Context is both internal to the patient (e.g. genes, gender, age, comorbidities, psychological distress, and catastrophizing), and a consequence of external factors (e.g. social, healthcare, and work environment). Context influences how people report their pain, and also how the nervous system processes nociceptive information. Treatment contexts moderate and mediate therapeutic effectiveness, dependent on treatment expectations, beliefs, and risk evaluation. Uptake of treatments, both in primary and secondary care, is further influenced by the contexts in which they are offered. Understanding the nature and consequences of context helps explain heterogeneity between different people with OA pain, and opens avenues for potentially powerful interventions that could improve their quality of life. Context can be adjusted through the clinician–patient relationship and by targeting risk factors for poor outcome. Concurrent weight reduction, and psychological and physiotherapeutic interventions illustrate the use of combination therapy to address multiple contextual aspects of OA pain.
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Holden, Melanie A., Martin J. Thomas, and Krysia S. Dziedzic. Miscellaneous physical therapies. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199668847.003.0026.
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Miscellaneous physical therapies, such as assistive devices, thermotherapy, manual therapy, and electrotherapy are commonly used to treat patients with osteoarthritis (OA) in addition to written information and exercise. However, the evidence underpinning specific miscellaneous physical therapies is often limited, with small study sizes, heterogeneous populations, and differing study designs making it difficult to draw firm conclusions about their effectiveness. One or more miscellaneous physical therapies feature within 15 current clinical guidelines for OA. The specific types of physical therapies addressed are variable, as are their recommendations. There is most agreement for miscellaneous physical therapies in hand OA, with multiple guidelines addressing and consistently recommending joint protection, splinting, and thermotherapy in addition to core treatment. However these recommendations are predominantly based on a small number of randomized controlled trials (RCTs). Use of walking aids and footwear is commonly addressed and recommended for patients with hip and knee OA, although recommendations are predominantly based on expert opinion. Other physical therapies recommended for hip and knee OA range from orthoses to less conventional leech therapy. When a recommendation for a miscellaneous physical therapy is not made, it is commonly due to limited clinical evidence, rather than evidence of harm. Due to limited evidence and lack of consensus between clinical guidelines, for some therapies, use of specific miscellaneous physical therapies in clinical practice should be based upon the best available evidence, a holistic, individualized clinical assessment and shared decision-making with the patient. Further large-scale, high-quality RCTs would be useful to inform future guideline recommendations and clinical practice.
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McDougall, Jason J., and Joel A. Vilensky. The innervation of the joint and its role in osteoarthritis pain. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199668847.003.0007.
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Diarthrodial joints possess an extensive network of sensory and sympathetic nerve fibres whose physiological functions are varied and complex. Nerves are primarily located in the synovium but also innervate the subchondral bone, the outer third of menisci, and the superficial surface of tendons and ligaments. Large-diameter, myelinated neurons are involved in joint position sense while small-diameter neurons with thin or no myelin typically sense pain. The small-diameter nerves in conjunction with sympathetic fibres control synovial blood flow and maintain joint homeostasis. In patients with osteoarthritis (OA), the sensory nerves become sensitized and increase their firing rate in response to normal movement. This peripheral sensitization is mediated by numerous algogenic agents released into the OA knee including neuropeptides, eicosanoids, and proteinases. A portion of joint afferents fire in the absence of mechanical stimuli and encode pain at rest. Interestingly, the firing rate of joint afferents does not correlate with OA severity, indicating that pain is a poor predictor of joint pathology. Evidence is accumulating to suggest that a subpopulation of OA patients who are unresponsive to classical non-steroidal anti-inflammatory drugs may be suffering from neuropathic pain in which there is damage to the joint nerves themselves. Better understanding of the biology of joint nerves could help in the development of patient-targeted therapies to alleviate OA pain and inflammation.
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Abhishek, Abhishek, Adrian Jones, and Michael Doherty. Topical pharmacological treatments. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199668847.003.0028.
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Topical pharmacological agents such as non-steroidal anti-inflammatory drugs (NSAIDs) and capsaicin are widely recommended as first-line analgesics in the treatment of osteoarthritis (OA) of the knee, hand, and potentially other peripheral joints in view of their safety and efficacy. Although initial studies were short in duration (2–4 weeks), recent randomized controlled trials have confirmed the efficacy of topical NSAIDs over longer (12-week) study periods. Systematic reviews demonstrate that their efficacy can be equivalent to oral NSAIDs for OA pain, but they have a significantly better systemic toxicity profile than the corresponding oral formulations. Topical capsaicin is less well studied than topical NSAIDs but has been demonstrated to be effective in several placebo-controlled clinical trials. Local warming and an uncomfortable burning sensation is a common problem with initial applications, but this subsides with continued treatment and can be minimized by using a low-strength preparation (e.g. 0.025%) initially. Several other topical treatments such as drug-free transfersome gel and local lignocaine patches have been shown to be effective in controlling pain due to OA. However, they have been studied in relatively few studies and currently are not recommended for general use.
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Arden, Nigel, and Terence O’Neill. Intra-articular injection therapy. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199668847.003.0032.
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Intra-articular injection therapy is widely used in the management of osteoarthritis (OA). It has advantages over oral therapy in that it can provide targeted therapy to individual joint sites and at higher dose than could be achieved through oral administration and with fewer adverse effects. Intra-articular steroid therapy, the most widely used intra-articular therapy, is safe and effective in the short term particularly at the knee; though more studies are needed to better characterize the longer-term benefit. The role of intra-articular hyaluronic acid in clinical management of OA is less clear though it may have a role in selected patients in whom other therapies are contraindicated. Currently there are no factors which have been identified as being predictors of response to therapy with intra-articular therapy. Many other intra-articular agents have been used in the management of OA, however, because of the limited evidence base relating to efficacy and safety they cannot currently be recommended for use in routine clinical practice.
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Hawker, Gillian, Anne Lyddiatt, Linda Li, Dawn Stacey, Susan Jaglal, Sarah Munce, and Esther Waugh. Patient information strategies for decision-making and management of osteoarthritis. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199668847.003.0021.
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Osteoarthritis (OA) is a chronic, disabling disease that warrants care that aligns with the principles of ‘chronic disease management’. Central to the success of chronic disease management is the ‘informed, activated patient’. Patient information strategies, including the use of patient decision aids, are essential to enabling patients with OA to self-manage their disease and engage in informed, shared decision-making. Such strategies are best delivered by a multidisciplinary team of healthcare providers and adapted to the characteristics, preferences, and values of the individual OA patient. Patients actively involved in their own disease management, that is, ‘self-management’, including shared goal-setting and decision-making about treatment interventions, are, on average, more adherent to treatment recommendations, have enhanced self-efficacy and, ultimately, experience better health outcomes.
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Wenham, Claire Y. J., and Philip G. Conaghan. Osteoarthritis—management. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199642489.003.0140.
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Osteoarthritis (OA) is a common condition which often causes pain and functional limitation, significantly impacting on a person's quality of life. A comprehensive assessment of the impact of OA should be performed before selecting therapies and treatment goals. Current recommended therapies include a combination of pharmacological and non-pharmacological therapies, which should be considered for all people with OA, regardless of anatomical site of involvement. Non-pharmacological treatments include education, muscle strengthening and aerobic exercises, weight loss if appropriate, splints and devices, and aids. Pharmacological therapies include paracetamol, oral and topical non-steroidal anti-inflammatory drugs, topical capsaicin, intra-articular corticosteroid injections, and opioids. Many existing therapies have only a small analgesic effect size and, in the case of drug therapies, may be associated with important side effects, so an individual's symptoms and comorbidities must be taken into account when selecting therapies. For those who do not respond to these treatments, surgery such as a total joint arthroplasty may be required. There is a strong need for new analgesic treatments for OA. As it is becoming increasingly clear that the sources of pain in OA are complex and multifactorial, future treatments for OA will need to target both peripheral and central pain mechanisms.
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Dekker, Joost, Daniel Bossen, Jasmijn Holla, Mariëtte de Rooij, Cindy Veenhof, and Marike van der Leeden. Psychological strategies in osteoarthritis of the knee or hip. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199668847.003.0025.
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Characteristic clinical presentations of osteoarthritis (OA) include pain and activity limitations. These presentations are dependent on psychological processes. The literature reviewed in this chapter leads to the following conclusions: (1) symptoms of depression, anxiety, and fatigue are more prevalent among patients with OA than among the general population. Recently, a depressive mood phenotype has been identified in knee OA. (2) Symptoms of depression, anxiety, and fatigue, as well as other psychological variables are established risk factors for future worsening of pain and activity limitations. (3) Psychological interventions such as depression care and pain coping skills training have been demonstrated to improve pain and activity limitations, as well as psychological outcomes. Self-management may have beneficial effects, although there is clearly room for improvement. Interventions combining psychological interventions with exercise therapy have been shown to be effective; improved outcome over exercise therapy alone stills needs to be demonstrated. (4) Psychological interventions are effective in improving exercise adherence and promoting physical activity. Overall, it can be concluded that the psychological approach towards OA is fruitful: the psychological approach has resulted in substantial contributions to the understanding and management of clinical presentations of OA, including pain and activity limitations.
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Kloppenburg, Margreet. Clinical assessment: signs, symptoms, and patient perceptions in osteoarthritis. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199668847.003.0015.
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Osteoarthritis (OA) is a disorder that can affect any joint. It results in a high clinical burden in many patients. Patients with OA experience a wide range of symptoms and clinical signs such as pain, disability, stiffness, tenderness, crepitus, and decreased mobility and strength in their osteoarthritic joints, where the impact depends on the involved joint. Also general symptoms such as fatigue and psychosocial consequences are experienced by OA patients. The impact of symptoms and signs does not only depend on osteoarthritic abnormalities, but also on patient factors, such as coping strategies and illness perceptions, and co-morbidities. In this chapter, general and joint-specific symptoms and signs as well as the impact of patient factors are discussed.
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Hayashi, Daichi, Ali Guermazi, and Frank W. Roemer. Radiography and computed tomography imaging of osteoarthritis. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199668847.003.0016.
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Osteoarthritis (OA) is the most prevalent joint disorder in the elderly worldwide and there is still no effective treatment, other than joint arthroplasty for end-stage OA, despite ongoing research efforts. Imaging is essential for assessing structural joint damage and disease progression. Radiography is the most widely used first-line imaging modality for structural OA evaluation. Its inherent limitations should be noted including lack of ability to directly visualize most OA-related pathological features in and around the joint, lack of sensitivity to longitudinal change and missing specificity of joint space narrowing, and technical difficulties regarding reproducibility of positioning of the joints in longitudinal studies. Magnetic resonance imaging (MRI) is widely applied in epidemiological studies and clinical trials. Computed tomography (CT) is an important additional tool that offers insight into high-resolution bony anatomical details and allows three-dimensional post-processing of imaging data, which is of particular importance for orthopaedic surgery planning. However, its major disadvantage is limitations in the assessment of soft tissue structures compared to MRI. CT arthrography can be useful in evaluation of focal cartilage defects or meniscal tears; however, its applicability may be limited due to its invasive nature. This chapter describes the roles and limitations of both conventional radiography and CT, including CT arthrography, in clinical practice and OA research. The emphasis is on OA of the knee, but other joints are also mentioned where appropriate.
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Abhishek, Abhishek, and Michael Doherty. Treatment of calcium pyrophosphate deposition. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199668847.003.0052.
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The treatment of calcium pyrophosphate crystal deposition (CPPD) is mainly symptomatic. Acute calcium pyrophosphate (CPP) crystal synovitis should be treated with rest, local application of ice packs, joint aspiration, and/or intra-articular corticosteroid injection (once joint sepsis has been excluded). Oral colchicine or prednisolone may be used if joint aspiration and/or injection are not feasible. Anti-inflammatory agents (with proton pump inhibitors) may be used but in general these should be avoided as most patients with acute CPP crystal arthritis are elderly, and at a high risk of gastrointestinal and renal complication of non-steroidal anti-inflammatory drug (NSAIDs). Principles of management of CPPD with osteoarthritis (OA) are identical to those for isolated OA. However, patients may have more inflammatory signs and symptoms and periodic joint aspiration and corticosteroid injection may be required more often than in isolated OA. Oral NSAIDs (with gastro-protection), colchicine, low-dose corticosteroids, hydroxychloroquine, and radiosynovectomy have been suggested as options for the treatment of chronic CPP crystal arthritis. There is growing interest in use of anti-interleukin-1 agents for acute or chronic CPP crystal arthritis but the efficacy of these agents has not been formally studied, and their use should be considered on an individual basis.
34
Vincent, Tonia L., and Linda Troeberg. Pathogenesis of osteoarthritis. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199642489.003.0138.
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Understanding pathogenic mechanism in disease is critical for development of targeted therapeutic strategies. Although there are, at this time, only a handful of experimental approaches for treating osteoarthritis (OA), until 10 years ago this disease was almost universally considered an unmodifiable condition. Emerging data during this time, largely fuelled by studies in rodent models, has completely changed the paradigm of disease pathogenesis and has for the first time, generated novel, realistic targets for this highly prevalent and disabling condition. These targets include the aggrecanases, members of the ADAMTS family, and collagenases, which together are critical for the early breakdown of the extracellular matrix of cartilage. Some recent success has also been demonstrated by targeting bone in disease. Development of pain in OA is complex and likely arises from different tissues at different stages of disease. In the following section we describe the pathological features of OA, and discuss the evolution of theories of OA pathogenesis and factors that have limited mechanistic clarity in this disease. We summarize the molecular pathways that are now known to be active in disease, and consider how these identified molecular pathways could be linked to known epidemiological risk factors. We finish by discussing possible future therapeutic strategies that will emerge from these discoveries and the current limitations in implementing new therapies in OA.
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Hunter, David J., Frank W. Roemer, and Ed Riordan. Imaging: magnetic resonance imaging. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199668847.003.0018.
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Magnetic resonance imaging (MRI) overcomes many of the limitations associated with conventional radiography, the technique historically regarded as the gold standard in imaging of osteoarthritis (OA). MRI allows visualization of changes and pathologies in joint tissues including cartilage and the menisci, the two tissue components responsible for the indirect radiographic marker of joint space narrowing, decreasing the length of time that must elapse before disease progression can be detected. Other elements of the joint can also be analysed simultaneously: a key development in the understanding of OA. This chapter focuses on the utility of MRI in observational studies and clinical trials, detailing the available MRI techniques and quantitative/qualitative measurements, and their correlation with tissue damage. The possible future directions of MRI in OA are also discussed, with a view to its potential utility in identifying disease-modifying interventions.
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Twarog, Emily E. LB. “Women—The Guardians of Price Control”. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780190685591.003.0003.
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When the Office of Price Administration introduced its wartime rationing program, the Home Front Pledge Campaign, it sought the help of America’s women through mass meetings and then follow-up meetings with local organizations. The OPA believed that its program would succeed only if every woman assumed an individual responsibility to hold prices in line. Chapter 2 explores the ways in which American housewives worked with the Office of Price Administration on wartime price controls; built alliances with a vast array of organizations through their involvement in the national consumer coalition, the Consumer Clearinghouse; and organized national meat boycotts during the post–World War II strike wave.
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Gersel, Johan, Rasmus Thybo Jensen, Morten S. Thaning, and Søren Overgaard, eds. In the Light of Experience. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780198809630.001.0001.
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A simple idea: Perception is of what is in view (before the eyes), or making noise, or the noises made, or emitting odours, or the thus emitted (etc.). What we see is, say, a pig, or its perambulations, or its rooting beneath that oak. Sight offers us a certain form of awareness of this, characterized in one way by its objects. It thus offers us occasion for another sort: we may recognize what we are aware of as, for example, a case of a pig rooting, or of an interminable drum machine. We take up the offer in exercising capacities for recognition such as they are. John McDowell has argued that this cannot be quite right (or anyway complete). For it needs to posit rational relations where there can be none. What follows argues that McDowell cannot be quite right: if he were, thought would cease to exist.
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Travis, Charles. The Move, the Divide, the Myth, and its Dogma. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780198809630.003.0004.
Full textAbstract:
A simple idea: Perception is of what is in view (before the eyes), or making noise, or the noises made, or emitting odours, or the thus emitted (etc.). What we see is, say, a pig, or its perambulations, or its rooting beneath that oak. Sight offers us a certain form of awareness of this, characterized in one way by its objects. It thus offers us occasion for another sort: we may recognize what we are aware of as, for example, a case of a pig rooting, or of an interminable drum machine. We take up the offer in exercising capacities for recognition such as they are. John McDowell has argued that this cannot be quite right (or anyway complete). For it needs to posit rational relations where there can be none. What follows argues that McDowell cannot be quite right: if he were, thought would cease to exist.
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Thorlund, Jonas Bloch, and L. Stefan Lohmander. Other surgical approaches in the management of osteoarthritis. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199668847.003.0034.
Full textAbstract:
Joint replacement is often considered the surgical treatment for patients with osteoarthritis (OA). However, several other surgical treatments, of which some are more frequently performed, have been advocated for patients with OA in order to relieve symptoms, stall progression, and avoid or postpone joint replacement. This chapter briefly describes the most common procedures such as knee and hip arthroscopy and knee and hip osteotomy. It also reviews the evidence for the efficacy of these treatments compared with non-surgical alternatives, which is frequently insufficient due to lack of controlled low-risk-of-bias studies. The risk of adverse events is also reported when data is available. Some of the more recent surgical techniques such as implantation of chondrocytes or stem cells are also described and discussed but their utility for treating osteoarthritis remains uncertain. There is a great need for continued innovation and development of surgical techniques for managing in particular the earlier stages of osteoarthritis. To reduce the risk of future costly failures, a stepwise introduction of new surgical procedures and devices must be encouraged.
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Abhishek, Abhishek, and Michael Doherty. Placebo, nocebo, and contextual effects. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199668847.003.0027.
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Placebo effect is an example of ‘contextual’ effect and is the symptomatic improvement experienced by patients who have unknowingly received a placebo (inactive treatment) instead of an active drug. It occurs due to patient-specific factors such as expectation of improvement and is influenced by the context in which the treatment is delivered. Nocebo effect is the opposite of placebo effect and includes worsening of symptoms or incident adverse effects due to expectancy or negative contextual or practitioner influence. Placebo effect has been demonstrated in a range of musculoskeletal conditions, including osteoarthritis (OA), as well as other conditions such as Parkinson’s disease, irritable bowel syndrome, and asthma. In OA, the placebo effect is strongest for subjective outcomes like pain. In fact, the effect size (ES) of placebo analgesia in OA clinical trials (0.51) is clinically significant and higher than the ES (defined by the additional improvement above placebo) obtained from non-pharmacological (0.25) and pharmacological (0.39) treatments. A number of patient- and intervention-specific and contextual factors influence the magnitude of placebo-induced improvements. Placebo analgesia is real, not a ‘trick of the mind’, and results from central mechanisms that increase descending inhibition of pain. Contextual effects are an integral part of everyday clinical practice. While patient- and intervention-specific determinants cannot be changed easily, healthcare practitioners should optimize the physician-specific factors that enhance positive contextual response and minimize nocebo response. Such a strategy that will increase the overall improvement is particularly relevant for OA where there is no ‘cure’ and a predominance of negative beliefs.
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Bennell, Kim L., Ans Van Ginckel, Fiona Dobson, and Rana S. Hinman. Exercise for the person with osteoarthritis. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199668847.003.0022.
Full textAbstract:
Because of its beneficial effects on pain and physical dysfunction commonly reported by afflicted individuals, all clinical guidelines of osteoarthritis (OA) advocate exercise therapy as a vital component of conservative management strategies. Although the optimal exercise modalities in terms of dosage, exercise type, or delivery mode are not yet known, clinical benefits can be achieved with a wide range of exercise types. While treatment effect sizes may be considered small to moderate, they are similar to those of common analgesic drugs or oral non-steroidal anti-inflammatories but seem to elicit fewer side effects. To achieve optimal treatment outcomes, programme parameters should be individualized to the patient’s clinical characteristics and preferences. Where validated instruments could assist the clinician in monitoring the progress of an exercise intervention programme, adherence to exercise in the longer term is a prerequisite to maintain symptom relief over time. Whereas the current body of evidence mainly comprises clinical trials in people with knee OA, future studies should continue to address efficacy and safety of exercise therapy in individuals suffering from hand or hip OA and should further determine its ability to postpone the need for costly arthroplasty surgery.
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Greve, Martin, ed. Writing the History of "Ottoman Music". Ergon Verlag, 2015. http://dx.doi.org/10.5771/9783956507038.
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Martin Greve: Introduction Bülent Aksoy: Preliminary Notes on the Possibility (or Impossibility) of Writing Ottoman Musical History Ralf Martin Jäger: Concepts of Western and Ottoman Music History Ruhi Ayangil: Thoughts and Suggestions on Writing Turkish Music History Ersu Pekin: Neither Dates nor Sources: A Methodological Problem in Writing the History of Ottoman Music Nilgün Dogrusöz: From Anatolian Edvâr (Musical Theory Book) Writers to Abdülbâkî Nâsir Dede: An Evaluation of the History of Ottoman/Turkish Music Theory Walter Feldman: The Musical “Renaissance” of Late Seventeenth Century Ottoman Turkey: Reflections on the Musical Materials of Ali Ufkî Bey (ca. 1610-1675), Hâfiz Post (d. 1694) and the “Marâghî” Repertoire Kyriakos Kalaitzidis: Post-Byzantine Musical Manuscripts as Sources for Oriental Secular Music: The Case of Petros Peloponnesios (1740-1778) and the Music of the Otto-man Court Gönül Paçaci: Changes in the Field of Turkish Music during the Late Ottoman/Early Republican Era Arzu Öztürkmen: The Quest for “National Music”: A Historical-Ethnographic Survey of New Approaches to Folk Music Research Okan Murat Öztürk: An Effective Means for Representing the Unity of Opposites: The Development of Ideology Concerning Folk Music in Turkey in the Context of Nationalism and Ethnic Identity Süley-man Senel: Ottoman Türkü Fikret Karakaya: Do Early Notation Collections Represent the Music of their Times? Sehvar Besiroglu: Demetrius Cantemir and the Music of his Time: The Concept of Authenticity and Types of Performance Andreas Haug: Reconstructing Western “Monophonic” Music Recep Uslu: Is an Echo of Seljuk Music Audible? A Methodological Research
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Konig, Christa. Ergativity in Africa. Edited by Jessica Coon, Diane Massam, and Lisa Demena Travis. Oxford University Press, 2017. http://dx.doi.org/10.1093/oxfordhb/9780198739371.013.37.
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Perhaps the most striking feature with regard to ergativity in Africa is its absence. Africa has long been seen as a continent without ergativity. Today a number of languages are being mentioned in the literature as having ergative features, even if only one language can be said to have a full-fledged ergative case system, namely Shilluk. Ergativity in Africa is closely related to marked nominative, where split systems are the norm. Ergativity is areally restricted to Eastern Africa, and runs genetically predominantly through the West Nilotic family of Nilo-Saharan. Ergativity is related to an odd OVA/SV word order pattern. There are different attempts that have been made to explain the emergence of ergativity from an historical perspective. The question whether marked nominative was first and ergativity second or the other way round is discussed controversially in the literature.
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Barsoum, Rashad S. Schistosomiasis. Edited by Neil Sheerin. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199592548.003.0182_update_001.
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AbstractSchistosomiasis is a parasitic disease that affects millions of people in 78 countries, where it is held responsible for considerable morbidity and mortality. It is caused by a blood fluke, which provokes an immunological response to hundreds of its antigens. This induces multi-organ pathology through the formation of tissue granulomata or circulating immune complexes. In addition, it is amyloidogenic and carcinogenic, through the interaction of immunological perturbation with confounding metabolic and genetic factors. The primary targets of schistosomiasis are urinary and hepatointestinal.The lower urinary tract is mainly affected in S. haematobium infection, and may lead to chronic pyelonephritis and/or obstructive nephropathy. The colon and liver are the targets of S. mansoni and S. japonicum infection, leading to hepatic fibrosis, portal hypertension, and liver failure. S. mansoni may also lead to immune complex glomerulonephritis, which is discussed elsewhere. Both S. haematobium and S. mansoni ova may be carried with the venous circulation to the lungs, where they provoke granulomatous and immune-mediated endothelial injury leading to cor-pulmonale. Ova may be subsequently carried with the arterial circulation to form ‘metastatic’ granulomas in other tissues, notably the brain (S. japonicum), spinal cord (S. haematobium), skin, conjunctiva, and genital organs.Schistosomiasis is preventable. World Health Organization programmes have successfully eradicated or reduced the incidence of infection in many countries, particularly Egypt and China. Prevention strategies include health education, raising hygiene standards, and interruption of the parasite’s life cycle by snail control and mass treatment. The search for a vaccine continues. Effective antiparasitic treatment is now possible with high elimination rates. Available agents include praziquantel and artemether for all species, metrifonate for S. haematobium, and oxamniquine for S. mansoni. Successful outcome correlates with early intervention, before fibrosis has occurred.
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Merchant, Tanya. Ancient Treasures, Modernized. University of Illinois Press, 2017. http://dx.doi.org/10.5406/illinois/9780252039539.003.0003.
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This chapter examines the role of women in the arranged folk music in Uzbekistan in the post-Soviet era. It looks at the rhetoric of Ro'za opa and her students, which focuses much more on musical literacy, virtuosity, and international standards. These priorities stem from the emancipatory impetus, during the Soviet period, to include women in the ethnonational project of creating folk orchestras. The chapter begins with a discussion of the assumptions of youth and femininity associated with certain dutar ensembles. It then traces the origins of dutar ensembles as they share history with similar ensembles from other former Soviet republics. It also presents the accounts of three prominent women musicians of the Soviet period: Faizila Shukurova, Firuza Abdurahimova, and Ro'zibi Hodjayeva. Finally, it considers the importance of Western art music to Tashkent's soundscape, and role that women play in this.
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Hardy, Thomas, and Linda M. Shires. Far from the Madding Crowd. Edited by Suzanne B. Falck-Yi. Oxford University Press, 2008. http://dx.doi.org/10.1093/owc/9780199537013.001.0001.
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‘I shall do one thing in this life – one thing for certain – that is, love you, and long for you, and keep wanting you till I die.’ Gabriel Oak is only one of three suitors for the hand of the beautiful and spirited Bathsheba Everdene. He must compete with the dashing young soldier Sergeant Troy and respectable, middle-aged Farmer Boldwood. And while their fates depend upon the choice Bathsheba makes, she discovers the terrible consequences of an inconstant heart. Far from the Madding Crowd was the first of Hardy’s novels to give the name of Wessex to the landscape of south-west England, and the first to gain him widespread popularity as a novelist. Set against the backdrop of the unchanging natural cycle of the year, the story both upholds and questions rural values with a startlingly modern sensibility. This new edition retains the critical text that restores previously deleted and revised passages.
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Franklin, Sara B., ed. Edna Lewis. University of North Carolina Press, 2018. http://dx.doi.org/10.5149/northcarolina/9781469638553.001.0001.
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Edna Lewis (1916-2006) wrote some of America's most resonant, lyrical, and significant cookbooks, including the now classic The Taste of Country Cooking. Lewis cooked and wrote as a means to explore her memories of childhood on a farm in Freetown, Virginia, a community first founded by black families freed from slavery. With such observations as "we would gather wild honey from the hollow of oak trees to go with the hot biscuits and pick wild strawberries to go with the heavy cream," she commemorated the seasonal richness of southern food. After living many years in New York City, where she became a chef and a political activist, she returned to the South and continued to write. Her reputation as a trailblazer in the revival of regional cooking and as a progenitor of the farm-to-table movement continues to grow. In this first-ever critical appreciation of Lewis's work, food-world stars gather to reveal their own encounters with Edna Lewis. Together they penetrate the mythology around Lewis and illuminate her legacy for a new generation, making a case for Lewis as a critical voice in African American foodways, and a pioneering professional woman chef, and the single most important figure in regional American food.
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Kersen, Thomas Michael. Where Misfits Fit. University Press of Mississippi, 2021. http://dx.doi.org/10.14325/mississippi/9781496835420.001.0001.
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All regions and places are unique in their own way, but the Ozarks have an enduring place in American culture. Studying the Ozarks offers the ability to explore American life through the lens of one of the last remaining cultural frontiers in American society. Perhaps because the Ozarks were relatively isolated from mainstream American society, or were at least relegated to the margins of it, their identity and culture are liminal and oftentimes counter to mainstream culture. Whatever the case, looking at the Ozarks offers insights into changing ideas about what it means to be an American and, more specifically, a special type of southerner. Thomas Michael Kersen explores the people who made a home in the Ozarks and the ways they contributed to American popular culture. He argues the area attracts and even nurtures people and groups on the margins of the mainstream. These include UFO enthusiasts, cults, musical troupes, and back-to-the-land groups. Kersen examines how the Ozarks became a haven for creative, innovative, even nutty people to express themselves—a place where community could be reimagined in a variety of ways. Chapters examine real and imagined identity and highlight how the area has contributed to popular culture through analysis of the Eureka Springs energy vortex, fictional characters like Li’l Abner, cultic activity, environmentally minded communes, and the development of rockabilly music and near-communal rock bands such as Black Oak Arkansas.
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Zimmerman, Aaron Z. Pragmatic Self-Deception. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780198809517.003.0006.
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To conclude the discussion, the author turns to James’s defense of the will to believe. Philosophers have tended to focus on the normative question of whether it is ever OK to adopt beliefs for pragmatic reasons. The “evidentialists” are prepared to criticize those who would resort to this sort of thing, and the intellectualists go further to argue that pragmatists are self-deceived. The author argues against these epistemic scolds. The social science of “positive illusions” confirms the coherence of James’s doctrine and provides an evidential basis for Bain’s theory of belief. Sometimes, we can ignore the evidence and believe what we want to believe knowing full well that this is what we are doing. The will to believe is real. Within limits, it can even be a good thing.
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Allen, Antija M., and Justin T. Stewart, eds. We're Not OK. Cambridge University Press, 2022. http://dx.doi.org/10.1017/9781009064668.
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In the United States, only 6% of the 1.5 million faculty in degree-granting postsecondary institutions is Black. Research shows that, while many institutions tout the idea of diversity recruitment, not much progress has been made to diversify faculty ranks, especially at research-intensive institutions. We're Not Ok shares the experiences of Black faculty to take the reader on a journey, from the obstacles of landing a full-time faculty position through the unique struggles of being a Black educator at a predominantly white institution, along with how these deterrents impact inclusion, retention, and mental health. The book provides practical strategies and recommendations for graduate students, faculty, staff, and administrators, along with changemakers, to make strides in diversity, equity, and inclusion. More than a presentation of statistics and anecdotes, it is the start of a dialogue with the intent of ushering actual change that can benefit Black faculty, their students, and their institutions.