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1

Ackley, Stephen F., Hongjie Xie, and Elizabeth A. Tichenor. "Ocean heat flux under Antarctic sea ice in the Bellingshausen and Amundsen Seas: two case studies." Annals of Glaciology 56, no. 69 (2015): 200–210. http://dx.doi.org/10.3189/2015aog69a890.

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AbstractWe examine the role of ocean heat flux (OHF) in Antarctic sea-ice growth and melt using data from autonomous ice mass-balance buoys deployed on pack ice in the Bellingshausen Sea and on fast ice in the Amundsen Sea during the spring/summer (October-December 2007) and summer/ autumn (February-March 2009) transitions, respectively. OHFs are derived using two methods that examine changes in (1) sub-ice ocean water properties (OHF1) and (2) ice thickness (OHF2), the latter only applying to thick snow-covered ice (i.e. a near-zero temperature gradient near the ice bottom). Good agreement is found between the time-averaged estimates of OHF1 and OHF2. Average OHF measured was 8 ± 2 W m-2 under the pack ice and 17 ± 2 W m-2 under the landfast ice. Some short-term OHF values (OHF1) in both seas exceeded 55 W m-2. The spring OHF variations in the Bellingshausen Sea were periodic and controlled by semi-diurnal ice velocity fluctuations. Larger temperature fluctuations in the summer Amundsen Sea, originating from incursions of warm deep water masses, contributed to the OHF being twice as high as in the Bellingshausen Sea and also accounted for the irregular OHF variability there.
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2

Larsen, Fenton E., and Stewart S. Higgins. "Tree Size of Ten Asian Pear Cultivars on Five Old Home × Farmingdale Rootstocks." HortScience 31, no. 4 (August 1996): 666b—666. http://dx.doi.org/10.21273/hortsci.31.4.666b.

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The influence of five Old Home × Farmingdale (OHF) rootstocks on tree size with 10 Asian pear scion cultivars was examined after 10 years in an experimental orchard in central Washington state. The effect of rootstock on tree size varied among scion cultivars. Within `Chojuro', `Hosui', `Niitaka', and `Seigyoku', trunk cross-sectional areas were similar regardless of rootstock. Within `Li', OHF 333 produced larger trees than OHF 282 and OHF 217. `Okusankichi' trees, which were generally the same size as `Hosui', were significantly larger on OHF 217 and OHF 97 than on OHF 333. `Kikusui' trees, which were generally similar in size to `Niitaka' and `Seigyoku', were larger on OHF 217, OHF 97, and OHF 282 than on OHF 333. `20th Century', which was similar in size to `Chojuro' and `Shinseiki', appeared to be the cultivar most sensitive to rootstock. `20th Century'/OHF 217 were significantly larger than trees on OHF 97 and OHF 282, which were larger than trees on OHF 51. `Shinseiki'/OHF 97 were larger than trees on OHF 333. The smallest trees were `Shinko', with trees on OHF 217, OHF 97, OHF 333, and OHF 51 all being larger than trees on OHF 282. Contrary to research with some European pear scions, consistent trends did not emerge from this research that would allow a general prediction of the relative influence of these five OHF clonal rootstocks on Asian pear tree size.
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3

Rudakov, N. V., V. K. Yastrebov, and V. V. Yakimenko. "Epidemiology of Omsk Haemorragic Fever." Epidemiology and Vaccine Prevention 14, no. 1 (February 20, 2015): 39–48. http://dx.doi.org/10.31631/2073-3046-2015-14-1-39-48.

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The main aspects of epidemiology and epizootology of omsk haemorrhagic fever (OHF) were analysed. Described: the discovery of virus OHF (1947), the first outbreak of new diseases in districts of Omsk region; comprehensive work for decryption the etiology of OHF of specialists from Omsk and Moscow institutes. In the long-term dynamics of activity of natural foci of OHF stand out 4 periods, what different intensity of epidemic and epizootic processes. The main reservoir of the virus OHF in natural foci and the source of human infection is muskrat. In maintaining populations of the virus is of some significance change of hosts (metaxenosis). Established independent position of the virus OHF in group Flaviviruses of mammals, transmitted by ticks. There are two genovariants of virus OHF.
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4

Jiang, Feng, Jiansha Gao, and Di Lang. "Photocatalytic Selective Degradation of Catechol and Resorcinol on the TiO2 with Exposed {001} Facets: Roles of Two Types of Hydroxyl Radicals." Catalysts 12, no. 4 (March 29, 2022): 378. http://dx.doi.org/10.3390/catal12040378.

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Photocatalytic studies on contaminant degradation in water suspension generally suggest that the degradation reaction mainly takes place on the surface of the photocatalysts rather than in the water phase. The mechanism of selective degradation is often difficult to distinguish concerning the contribution of adsorption and radical selectivity. This study is thus designed to investigate the roles of two types of hydroxyl radicals, adsorbed hydroxyl radical (·OHa) and free hydroxyl radical (·OHf), on the selective degradation of catechol (CT) and resorcinol (RE). CT and RE are significantly different in adsorption on a TiO2 photocatalyst with a highly exposed {001} facet. CT can be selectively degraded by TiO2 and was highly correlated with adsorption. Free radical quenching experiment results showed that the degradation of CT can be identified as the combined effect of both ·OHa and ·OHf, while the degradation of RE was mainly due to the ·OHf. Electron paramagnetic resonance coupled with spin trapping agents was used to detect the relative concentration of hydroxyl radicals in all the photocatalytic degradation processes. After a series analysis, we proposed that the mechanism of selective degradation mainly depends on the concentration of ·OHf for the pollutant molecules with weak adsorption on the catalyst surface.
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5

Deccache, Carole, Thierry Hamon, Maxime Morsa, Vincent De Andrade, Maria Grazia Albano, and Rémi Gagnayre. "Helping patients to learn: characteristics and types of users and uses of independent online forums on health problems and chronic conditions." Education Thérapeutique du Patient - Therapeutic Patient Education 11, no. 1 (May 27, 2019): 10208. http://dx.doi.org/10.1051/tpe/2019008.

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Background Patients are using online health forums (OHFs) to exchange about their health, diseases and treatments. Some OHFs are independent, not submitted to health care providers’ control nor to social desirability. This must probably influence the very nature of patient’s learning. Objectives: This research aims to bring some answers to the following questions: What are the characteristics of independent OHFs? What are OHF internaut patients’ profile? How do they use OHFs? Are there any characteristics that might help to understand their use of OHFs? Methods: A literature review has been undertaken querying 10 databases. The review was completed with an analysis of the “grey literature”. Eleven keywords were used singly or in combination. The article selection was conducted by two independent researchers. Results: 23 documents were selected and analysed. Five OHF definitions, three user’s classifications and four OHF uses were identified and analysed. Discussion: The review allowed us to 1) formulate a definition of a chronic health conditions oriented OHF, 2) describe its characteristics, 3) suggest a users’ classification and, 4) describe the four OHF uses. Conclusions: Independent OHF is a virtual and free space beyond institutional control. It may be considered as a learning and educational media, formal and informal, and spontaneous. The understanding of the knowledge acquisition processes and strategies among OHF users is necessary in order to use this web tool as patient education strategy.
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6

Wu, Xingren, W. F. Budd, A. P. Worby, and Ian Allison. "Sensitivity of the Antarctic sea-ice distribution to oceanic heat flux in a coupled atmosphere-sea-ice model." Annals of Glaciology 33 (2001): 577–84. http://dx.doi.org/10.3189/172756401781818545.

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AbstractA coupled atmosphere-sea-ice model is used to study the sensitivity of the Antarctic sea-ice distribution to oceanic heat flux (OHF). Remote sensing of sea ice from microwave radiometers provides data on ice extent and ice concentration. The ice-thickness data used are from ship-based observations. Our simulations suggest that OHF values of 0−5 W m−2 will cause sea ice to be too thick in the model. A value of 20−25 Wm−2 throughout the year causes sea ice to be too thin in the model. The model results indicate that a seasonally varying OHF is required to match the modelled thickness with observations. Values of 5−30 Wm with an annual mean of 10−15 Wm−2, give a reasonable distribution of sea-ice thickness. This agrees with the limited observations of OHF available for the Antarctic. The model results also indicate that the OHF should be varied spatially. When a seasonally and spatially variable OHF is applied to the coupled atmosphere-sea-ice model a still better simulation of the sea-ice distribution is obtained. Our results also suggest that the role of ice advection is very important in the determination of the sea-ice distribution, and it can be quantified by the model.
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7

Khan, I. Y., V. Dekou, G. Douglas, R. Jensen, M. A. Hanson, L. Poston, and P. D. Taylor. "A high-fat diet during rat pregnancy or suckling induces cardiovascular dysfunction in adult offspring." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 288, no. 1 (January 2005): R127—R133. http://dx.doi.org/10.1152/ajpregu.00354.2004.

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Epidemiological and animal studies suggest that diet-induced epigenetic modifications in early life can contribute to development of the metabolic syndrome in adulthood. We previously reported features of the metabolic syndrome in adult offspring of rats fed a diet rich in animal fat during pregnancy and suckling. We now report a study to compare the relative effects of high-fat feeding during 1) pregnancy and 2) the suckling period in the development of these disorders. As observed previously, 6-mo-old female offspring of fat-fed dams suckled by the same fat-fed dams (OHF) demonstrated raised blood pressure, despite being fed a balanced diet from weaning. Female offspring of fat-fed dams “cross fostered” to dams consuming a control diet during suckling (OHF/C) demonstrated raised blood pressure compared with controls (OC) [systolic blood pressure (SBP; mmHg) means ± SE: OHF/C, 132.5 ± 3.0, n = 6 vs. OC, 119.0 ± 3.8, n = 7, P < 0.05]. Female offspring of controls cross fostered to dams consuming the fat diet (OC/HF) were also hypertensive [SBP (mmHg) 131.0 ± 2.5 mmHg, n = 6 vs. OC, P < 0.05]. Endothelium-dependent relaxation (EDR) of male and female OHF and OHF/C mesenteric small arteries was similar and blunted compared with OC ( P < 0.001). OC/HF arteries showed profoundly impaired EDR (OC/HF vs. OHF, P < 0.001). OHF/C and OC/HF demonstrated hyperinsulinemia and increased adiposity. Features of the metabolic syndrome in adult offspring of fat-fed rats can be acquired both antenatally and during suckling. However, exposure during pregnancy confers adaptive protection against endothelial dysfunction induced by maternal fat feeding during suckling.
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8

Yamamoto, Noboru, Tomohide Tamura, Yoshikazu Kamiya, Ikuo Sekine, Hideo Kunitoh, and Nagahiro Saijo. "Correlation Between Docetaxel Clearance and Estimated Cytochrome P450 Activity by Urinary Metabolite of Exogenous Cortisol." Journal of Clinical Oncology 18, no. 11 (June 11, 2000): 2301–8. http://dx.doi.org/10.1200/jco.2000.18.11.2301.

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PURPOSE: There is no simple and practical method for the estimation of the interpatient variability of cytochrome P450 (CYP3A4) enzyme activity. Cortisol is metabolized by this enzyme and excreted as 6-beta-hydroxycortisol (6β-OHF) and free-cortisol (FC) in urine, and docetaxel is also metabolized by hepatic CYP3A4 enzyme. We developed a new method for the estimation of CYP3A4 activity by measuring urinary cortisol metabolite after administration of exogenous cortisol. This study was aimed at assessing the predictability of the individual activity of CYP3A4 estimated by this method. PATIENTS AND METHODS: Thirty patients with advanced non–small-cell lung cancer were entered onto this study. Hydrocortisone 300 mg was administered intravenously, and urinary 6β-OHF and FC were measured. More than 2 days later, 60 mg/m2 of docetaxel was administered intravenously with pharmacokinetic sampling. The correlation between docetaxel pharmacokinetics and estimated interpatient variability of CYP3A4 activity with the application of our method was assessed. RESULTS: After cortisol administration, the total amount of 24-hour urinary 6β-OHF (T6β-OHF) increased about 60-fold compared with pretreatment levels, averaging 12,273 ± 4,076 μg/d (mean ± SD). Docetaxel clearance (CL) and area under the concentration-time curve averaged 24.5 ± 6.4 L/h/m2 and 2.66 ± 0.91 mg/L 8729· h, respectively. An excellent correlation between docetaxel CL and T6β-OHF was observed (r = .867). In multivariate analysis, T6β-OHF (P < .001), alpha-1-acid glycoprotein (P < .004), AST (P = .007), and age (P = .022) significantly correlated with docetaxel CL. CONCLUSION: The interpatient variability of CYP3A4 activity and docetaxel CL could be predicted by measuring T6β-OHF after cortisol administration.
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9

Taylor, Paul D., Josie McConnell, Imran Y. Khan, Kathleen Holemans, Kevin M. Lawrence, Henry Asare-Anane, Shanta J. Persaud, et al. "Impaired glucose homeostasis and mitochondrial abnormalities in offspring of rats fed a fat-rich diet in pregnancy." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 288, no. 1 (January 2005): R134—R139. http://dx.doi.org/10.1152/ajpregu.00355.2004.

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We previously reported that prenatal and suckling exposure to a maternal diet rich in animal fat leads to cardiovascular dysfunction in young adult rat offspring with subsequent development of dyslipidemia and hyperglycemia. We have further investigated glucose homeostasis in adult female offspring by euglycemic-hyperinsulinemic clamp and by dynamic assessment of glucose-stimulated insulin secretion in isolated, perifused pancreatic islet cells. Additionally, given the link between reduced mitochondrial DNA (mtDNA) content and the development of type 2 diabetes mellitus, we have measured mtDNA in organs from young adult animals. Sprague-Dawley rats were fed a diet rich in animal fat or normal chow throughout pregnancy and weaning. Infusion of insulin (5 mU·kg−1·min−1) resulted in a higher steady-state plasma insulin concentration in 1-year-old offspring of fat-fed dams (OHF, n = 4) vs. offspring of control dams (OC, n = 4, P < 0.01). Glucose-stimulated insulin secretion in isolated islets from 9-mo-old OHF was significantly reduced compared with OC ( n = 4, P < 0.05). Transmission electron micrography showed altered insulin secretory granule morphology in OHF pancreatic β-cells. Kidney mtDNA was reduced in 3-mo-old OHF [16S-to-18S gene ratio: OC ( n = 10) 1.05 ± 0.19 vs. OHF ( n = 10) 0.66 ± 0.06, P < 0.05]. At 6 mo, gene chip microarray of OHF aorta showed reduced expression of the mitochondrial genome. Prenatal and suckling exposure to a diet rich in animal fat leads to whole body insulin resistance and pancreatic β-cell dysfunction in adulthood, which is preceded by reduced tissue mtDNA content and altered mitochondrial gene expression.
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10

Zhiri, A., H. A. Mayer, V. Michaux, M. Wellman-Bednawska, and G. Siest. "6 beta-hydroxycortisol in serum and urine as determined by enzyme immunoassay on microtitre plates." Clinical Chemistry 32, no. 11 (November 1, 1986): 2094–97. http://dx.doi.org/10.1093/clinchem/32.11.2094.

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Abstract We modified our previous enzyme immunoassay (Clin Chim Acta 1986;157:267-76) for estimating 6 beta-hydroxycortisol (6 beta-OHF) to provide a more routine procedure for measuring it in urine and to increase sensitivity for its measurement in serum. Precision, analytical recovery, specificity, and detection limit are reported. 6 beta-OHF and 17-hydroxycorticosteroids in 24-h and 4-h (08:00-12:00 h) urine collections from healthy volunteers showed no significant day-to-day differences in excretion rate for either collection period. Mean values for 6 beta-OHF in serum of men, women, and women taking oral contraceptives showed no significant differences among these groups.
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11

González-Sánchez, Lola, Susana Gómez-Carrasco, Alfredo Aguado, Miguel Paniagua, M. Luz Hernández, José M. Alvariño, and Octavio Roncero. "Transition state dynamics of OHF on several electronic states: Photodetachment spectrum of OHF− and conical intersections." Journal of Chemical Physics 121, no. 20 (November 22, 2004): 9865–75. http://dx.doi.org/10.1063/1.1807375.

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12

Clamp, Louise, Anthony P. J. Hehir, Estelle V. Lambert, Christoph Beglinger, and Julia H. Goedecke. "Lean and obese dietary phenotypes: differences in energy and substrate metabolism and appetite." British Journal of Nutrition 114, no. 10 (September 18, 2015): 1724–33. http://dx.doi.org/10.1017/s0007114515003402.

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AbstractThis study aimed to characterise lean and obese phenotypes according to diet and body composition, and to compare fasting and postprandial appetite and metabolic profiles following a high-fat test meal. A total of ten lean (BMI<25 kg/m2) high-fat (LHF), ten lean low-fat (LLF; >40 and <30 % energy from fat) and ten obese (BMI>30 kg/m2) high-fat consumers (OHF; >40 % energy from fat) were recruited. Before and following the test meal (4727 kJ (1130 kcal), 77 % fat, 20 % carbohydrate (CHO) and 3 % protein), fasting plasma glucose, insulin, leptin, ghrelin, peptide YY (PYY), RER, RMR and subjective appetite ratings (AR) were measured for 6 h. Thereafter, subjects consumed a self-selected portion of a standardised post-test meal (40 % fat, 45 % CHO and 15 % protein) and reported AR. Fasting (P=0·01) and postprandial (P<0·001) fat oxidation was significantly higher in LHF than in LLF but was not different between LHF and OHF. Although similar between the lean groups, fasting and postprandial energy expenditures were significantly higher in OHF compared with LHF (P<0·01). Despite similar AR across groups, LLF consumed a relatively greater quantity of the post-test meal than did LHF (7·87 (sd 2·96) v. 7·23 (sd 2·67) g/kg, P=0·013). The lean groups showed appropriate changes in plasma ghrelin and PYY following the test meal, whereas the OHF group showed a blunted response. In conclusion, the LHF phenotype had a greater capacity for fat oxidation, which may be protective against weight gain. OHF individuals had a blunted appetite hormone response to the high-fat test meal, which may subsequently increase energy intake, driving further weight gain.
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Rocha, Carlos Henrique Lopes, Flaviane Maria Galvão Rocha, and Cristina De Andrade Monteiro. "MODELO ALTERNATIVO DE TRATAMENTO DE VULVOVAGINITE CAUSADA POR Candida glabrata COM UMA FRAÇÃO DE N-BUTANOL DAS FOLHAS DE Terminalia catappa." Revista de Investigação Biomédica 10, no. 2 (April 22, 2019): 181. http://dx.doi.org/10.24863/rib.v10i2.289.

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O objetivo principal deste trabalho foi avaliar o perfil de susceptibilidade de isolados clínicos de Candida glabrata através da técnica de difusão em ágar a uma fração extraída com n-butanol das folhas de Terminalia catappa (F-OHf), comparando este tratamento com um outro realizado com o antifúngico de uso clínico e tradicional, o fluconazol (FCZ). A F-OHf apresentou atividade inibitória contra os isolados de C. glabrata, as zonas de inibição de crescimento variaram entre 19 a 27 mm para o tratamento com 40 mg/mL e entre 24 a 31 mm para a concentração 100 mg/mL, para o FCZ as zonas de inibição variaram de 0 a 5 mm. Em sua totalidade, F-OHf pode ser uma alternativa promissora para o tratamento da candidíase, estes resultados representam novas perspectivas para futuras pesquisas em continuação a este estudo para desenvolver terapias alternativas no combate destas infecções.
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14

Johnson, Craig J., Kimberly J. Ferguson-Walter, Robert S. Gutzwiller, Dakota D. Scott, and Nancy J. Cooke. "Investigating Cyber Attacker Team Cognition." Proceedings of the Human Factors and Ergonomics Society Annual Meeting 66, no. 1 (September 2022): 105–9. http://dx.doi.org/10.1177/1071181322661132.

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Cyber attackers commonly operate in teams, which may process information collectively and thus, may be best understood when the team is treated as the unit of analysis. Future research in Oppositional Human Factors (OHF) should consider the impact of team-influencing and team-level biases and the impact that defensive interventions have on team cognition in general. Existing measurement approaches using team interactions may be well suited for studying red teams, and how OHF interventions impact cyber attackers.
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Reynolds, R. M., L. A. Shakerdi, K. Sandhu, A. M. Wallace, P. J. Wood, and B. R. Walker. "The utility of three different methods for measuring urinary 18-hydroxycortisol in the differential diagnosis of suspected primary hyperaldosteronism." European Journal of Endocrinology 152, no. 6 (June 2005): 903–7. http://dx.doi.org/10.1530/eje.1.01922.

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Objective: Urine 18-hydroxycortisol (18-OHF) measurements are claimed to discriminate between primary hyperaldosteronism due to Conn’s syndrome/adrenal adenoma or idiopathic bilateral adrenal hyperplasia (BAH), and also to identify cases of glucocorticoid-suppressible hyperaldosteronism (GSH). We have evaluated three urine 18-OHF methods using a panel of urine samples from patients with hypertension. Design: Clinical methods comparative study. Methods: Urine samples from patients with primary hyperaldosteronism due to either adenoma (n = 6), BAH (n = 6), GSH (n = 9), or essential hypertension (n = 38) were analysed without knowledge of the diagnosis using three different methods in different laboratories. These included ‘in-house’ radioimmunoassay (RIA), ‘in-house’ time-resolved fluorometric assay (DELFIA), and gas chromatography mass spectrometry (GC-MS). Results: The three assays showed good correlation, but there were large bias differences: RIA bias was greater than DELFIA which was greater than GC-MS. Discrimination between adenoma and BAH patients was best for the DELFIA method, with no overlap between results for these two groups. All three methods gave significantly elevated results for the GSH group compared with the BAH and essential hypertension groups. No assay distinguished BAH from essential hypertension. Conclusion: Measurement of urine 18-OHF may be a useful additional test in the differential diagnosis of primary hyperaldosteronism. The clinical diagnostic value of urinary 18-OHF measurements is method-dependent with the DELFIA assay having the best discriminatory value.
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Nguyen, Long The, Hui Chen, Crystal Mak, Amgad Zaky, Carol Pollock, and Sonia Saad. "SRT1720 attenuates obesity and insulin resistance but not liver damage in the offspring due to maternal and postnatal high-fat diet consumption." American Journal of Physiology-Endocrinology and Metabolism 315, no. 2 (August 1, 2018): E196—E203. http://dx.doi.org/10.1152/ajpendo.00472.2017.

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Recent studies indicate that sirtuin-1 (SIRT1), an important metabolic sensor and regulator of life span, plays a mechanistic role in maternal obesity-induced programming of metabolic disorders in the offspring. In this study we investigate whether SIRT1 activation in early childhood can mitigate metabolic disorders due to maternal and postnatal high-fat feeding in mice. Male offspring born to chow-fed (MC) or high fat diet-fed dams (MHF) were weaned onto postnatal chow or high-fat diet and treated with SRT1720 (25 mg/kg ip every 2 days) or vehicle control for 6 wk and examined for metabolic disorders. MHF exacerbated offspring body weight and insulin resistance in the offspring exposed to postnatal HFD (OHF). These metabolic changes were associated with reduced hepatic lipid droplet accumulation but increased plasma levels of alanine aminotransferase (ALT), a marker of liver damage. SRT1720 significantly decreased offspring body weight, adiposity, glucose intolerance, and hyperleptinemia due to OHF and reversed hyperinsulinemia and adipocyte hypertrophy due to the additive effects of MHF. Although SRT1720 suppresses liver lipogenesis, inflammation, and oxidative stress markers, it also reduces antioxidants and increased liver collagen deposition in OHF offspring independent of MHF. Hepatic steatosis was attenuated only in MC/OHF offspring in association with elevated plasma ALT levels. The study suggests that postnatal SRT1720 administration can mitigate obesity and insulin resistance in the offspring due to maternal and postnatal HFD exposure. However, the possibility of liver toxicity needs to be further examined.
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Uçgun, Kadir, Sinan Butar, Melike Çetinbaş, Mesut Altındal, and Murat Cansu. "Effect of Grafting on Iron Uptake of Farold 40, OHF 333 and OHF 87 Pear Rootstocks from the Soil." Communications in Soil Science and Plant Analysis 52, no. 2 (December 14, 2020): 128–35. http://dx.doi.org/10.1080/00103624.2020.1854285.

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Gao, Jun, Ninghao Liu, Mark Lawley, and Xia Hu. "An Interpretable Classification Framework for Information Extraction from Online Healthcare Forums." Journal of Healthcare Engineering 2017 (2017): 1–12. http://dx.doi.org/10.1155/2017/2460174.

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Online healthcare forums (OHFs) have become increasingly popular for patients to share their health-related experiences. The healthcare-related texts posted in OHFs could help doctors and patients better understand specific diseases and the situations of other patients. To extract the meaning of a post, a commonly used way is to classify the sentences into several predefined categories of different semantics. However, the unstructured form of online posts brings challenges to existing classification algorithms. In addition, though many sophisticated classification models such as deep neural networks may have good predictive power, it is hard to interpret the models and the prediction results, which is, however, critical in healthcare applications. To tackle the challenges above, we propose an effective and interpretable OHF post classification framework. Specifically, we classify sentences into three classes: medication, symptom, and background. Each sentence is projected into an interpretable feature space consisting of labeled sequential patterns, UMLS semantic types, and other heuristic features. A forest-based model is developed for categorizing OHF posts. An interpretation method is also developed, where the decision rules can be explicitly extracted to gain an insight of useful information in texts. Experimental results on real-world OHF data demonstrate the effectiveness of our proposed computational framework.
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Hussain, Aftab, Haiyan Yuan, Wenliang Li, and Jingping Zhang. "Theoretical investigations of the realization of sky-blue to blue TADF materials via CH/N and H/CN substitution at the diphenylsulphone acceptor." Journal of Materials Chemistry C 7, no. 22 (2019): 6685–91. http://dx.doi.org/10.1039/c9tc01449g.

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Gómez-Carrasco, Susana, Alfredo Aguado, Miguel Paniagua, and Octavio Roncero. "Coupled diabatic potential energy surfaces for studying the nonadiabatic dynamics at conical intersections in angular resolved photodetachment simulations of OHF−→OHF+e−." Journal of Chemical Physics 125, no. 16 (October 28, 2006): 164321. http://dx.doi.org/10.1063/1.2363988.

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21

Parnell, Jill A., and Raylene A. Reimer. "Prebiotic fibres dose-dependently increase satiety hormones and alter Bacteroidetes and Firmicutes in lean and obese JCR:LA-cp rats." British Journal of Nutrition 107, no. 4 (July 15, 2011): 601–13. http://dx.doi.org/10.1017/s0007114511003163.

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There is a growing interest in modulating gut microbiota with diet in the context of obesity. The purpose of the present study was to evaluate the dose-dependent effects of prebiotics (inulin and oligofructose) on gut satiety hormones, energy expenditure, gastric emptying and gut microbiota. Male lean and obese JCR:LA-cp rats were randomised to either of the following: lean 0 % fibre (LC), lean 10 % fibre (LF), lean 20 % fibre (LHF), obese 0 % fibre (OC), obese 10 % fibre (OF) or obese 20 % fibre (OHF). Body composition, gastric emptying, energy expenditure, plasma satiety hormone concentrations and gut microbiota (using quantitative PCR) were measured. Caecal proglucagon and peptide YY mRNA levels were up-regulated 2-fold in the LF, OF and OHF groups and 3-fold in the LHF group. GhrelinO-acyltransferase mRNA levels were higher in obesev.lean rats and decreased in the OHF group. Plasma ghrelin response was attenuated in the LHF group. Microbial species measured in the Bacteroidetes division decreased, whereas those in the Firmicutes increased in obesev.lean rats and improved with prebiotic intake.BifidobacteriumandLactobacillusincreased in the OHFv.OC group.Bacteroidesand total bacteria negatively correlated with percentage of body fat and body weight. Enterobacteriaceae increased in conjunction with glucose area under the curve (AUC) and glucagon-like peptide-1 AUC.Bacteroidesand total bacteria correlated positively with ghrelin AUC yet negatively with insulin AUC and energy intake (P < 0·05). Several of the mechanisms through which prebiotics act (food intake, satiety hormones and alterations in gut microbiota) are regulated in a dose-dependent manner. The combined effects of prebiotics may have therapeutic potential for obesity.
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Elghobashi, Nadia, and Leticia González. "A theoretical anharmonic study of the infrared absorption spectra of FHF−, FDF−, OHF−, and ODF− anions." Journal of Chemical Physics 124, no. 17 (May 7, 2006): 174308. http://dx.doi.org/10.1063/1.2191042.

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23

Hampton, Matthew, Richard Stevens, Adrian Highland, Richard Gibson, and Mark B. Davies. "Differential diagnosis of acute traumatic hip pain in the elderly." Acta Orthopaedica Belgica 87, no. 1 (March 31, 2021): 1–7. http://dx.doi.org/10.52628/87.1.01.

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Elderly patients who present with an inability to weight bear following a fall, with normal radiographs, should be appropriately investigated to rule out an occult hip fracture (OHF). We aim to identify both the range and incidence of the differential diagnosis of acute traumatic hip pain in a large series of patients investigated for OHF. A retrospective analysis of consecutive patients investigated for an OHF with magnetic resonance imaging (MRI) was performed. Dedicated musculo- skeletal radiologists reported the MRI scans. All diagnoses including hip fractures, other fractures and soft tissue injuries were recorded. Case notes were reviewed for all patients to identify subsequent complications, management and outcomes. A total of 157 patients fulfilled the inclusion criteria. 52 (33%) patients had a fracture of the proximal femur. The majority of patients with proximal femoral fractures required surgical intervention. 9 patients who had fractures of the greater trochanter of the femur without fracture extension across the femoral neck were managed non-operatively. 40 (25%) patients had fractures of the pelvis, with a combined pubic rami and sacral fracture occurring frequently. The most common diagnosis was a soft tissue injury alone that was seen in 60 (38%) patients imaged. Injuries to the gluteal muscle group, iliopsaos complex and trochanteric bursa were most prevalent. All patients with soft tissue injuries or fractures of the pelvis were successfully managed non-operatively. This study highlights a wide range of differential diagnoses in elderly patients presenting with acute traumatic hip pain. The proximal femur was frac- tured in 33% of patients imaged for OHFs in our series. The most common diagnosis was a soft tissue injury around the hip and pelvis ; these injuries can be successfully managed without surgery.
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Yamamoto, Noboru, Tomohide Tamura, Haruyasu Murakami, Tatsu Shimoyama, Hiroshi Nokihara, Yutaka Ueda, Ikuo Sekine, et al. "Randomized Pharmacokinetic and Pharmacodynamic Study of Docetaxel: Dosing Based on Body-Surface Area Compared With Individualized Dosing Based on Cytochrome P450 Activity Estimated Using a Urinary Metabolite of Exogenous Cortisol." Journal of Clinical Oncology 23, no. 6 (February 20, 2005): 1061–69. http://dx.doi.org/10.1200/jco.2005.11.036.

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Purpose Docetaxel is metabolized by cytochrome P450 (CYP3A4) enzyme, and the area under the concentration-time curve (AUC) is correlated with neutropenia. We developed a novel method for estimating the interpatient variability of CYP3A4 activity by the urinary metabolite of exogenous cortisol (6-beta-hydroxycortisol [6-β-OHF]). This study was designed to assess whether the application of our method to individualized dosing could decrease pharmacokinetic (PK) and pharmacodynamic (PD) variability compared with body-surface area (BSA) –based dosing. Patients and Methods Fifty-nine patients with advanced non–small-cell lung cancer were randomly assigned to either the BSA-based arm or individualized arm. In the BSA-based arm, 60 mg/m2 of docetaxel was administered. In the individualized arm, individualized doses of docetaxel were calculated from the estimated clearance (estimated clearance = 31.177 + [7.655 × 10−4 × total 6-β-OHF] − [4.02 × alpha-1 acid glycoprotein] − [0.172 × AST] − [0.125 × age]) and the target AUC of 2.66 mg/L · h. Results In the individualized arm, individualized doses of docetaxel ranged from 37.4 to 76.4 mg/m2 (mean, 58.1 mg/m2). The mean AUC and standard deviation (SD) were 2.71 (range, 2.02 to 3.40 mg/L · h) and 0.40 mg/L · h in the BSA-based arm, and 2.64 (range, 2.15 to 3.07 mg/L · h) and 0.22 mg/L · h in the individualized arm, respectively. The SD of the AUC was significantly smaller in the individualized arm than in the BSA-based arm (P < .01). The percentage decrease in absolute neutrophil count (ANC) averaged 87.1% (range, 59.0 to 97.7%; SD, 8.7) in the BSA-based arm, and 87.4% (range, 78.0 to 97.2%; SD, 6.1) in the individualized arm, suggesting that the interpatient variability in percent decrease in ANC was slightly smaller in the individualized arm. Conclusion The individualized dosing method based on the total amount of urinary 6-β-OHF after cortisol administration can decrease PK variability of docetaxel.
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García-Chapa, M., A. Batlle, A. Laviña, A. Camprubí, V. Estaún, and C. Calvet. "TOLERANCE INCREASE TO PEAR DECLINE PHYTOPLASMA IN MYCORRHIZAL OHF-333 PEAR ROOTSTOCK." Acta Horticulturae, no. 657 (September 2004): 437–41. http://dx.doi.org/10.17660/actahortic.2004.657.70.

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26

Elghobashi-Meinhardt, Nadia, Leticia González, Ingo Barth, and Tamar Seideman. "Few-cycle laser pulses to obtain spatial separation of OHF− dissociation products." Journal of Chemical Physics 130, no. 2 (January 14, 2009): 024310. http://dx.doi.org/10.1063/1.3054276.

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YAMAGUCHI, IKUMATSU. "Human urinary 6.BETA.-OHF/F ratio as a CYP3A active index." Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics 29, no. 1/2 (1998): 225–26. http://dx.doi.org/10.3999/jscpt.29.225.

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Desfrère, Luc, M. Farhat, M. Couchard, P.-H. Jarreau, J.-P. Relier, and G. Moriette. "Incidence des hemorragies intraventriculaires selon le mode de ventilation (ohf et vmc)." Archives de Pédiatrie 4 (January 1997): 229s. http://dx.doi.org/10.1016/s0929-693x(97)86568-2.

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Spence, R. D., and C. H. Mattus. "Laboratory stabilization/solidification of tank sludges: GAAT, OHF, and combined tank sets." Journal of Environmental Management 70, no. 3 (March 2004): 203–14. http://dx.doi.org/10.1016/j.jenvman.2003.12.004.

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Nacheva, L. R., P. S. Gercheva, and V. T. Dzhuvinov. "EFFICIENT SHOOT REGENERATION SYSTEM OF PEAR ROOTSTOCK OHF 333 (PYRUS COMMUNIS L.) LEAVES." Acta Horticulturae, no. 839 (July 2009): 195–201. http://dx.doi.org/10.17660/actahortic.2009.839.23.

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DIXON, RICHARD N., and HIROTO TACHIKAWA. "The photodetachment spectrum of OHF−: the influence of vibration at a transition state." Molecular Physics 97, no. 1-2 (July 20, 1999): 195–203. http://dx.doi.org/10.1080/00268979909482822.

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TACHIKAWA, RICHARD N. DIXON, HIROTO. "The photodetachment spectrum of OHF : the influence of vibration at a transition state." Molecular Physics 97, no. 1 (July 10, 1999): 195–203. http://dx.doi.org/10.1080/002689799164045.

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33

Jamshidi, Saeid, Abbas Yadollahi, Mohammad Mehdi Arab, Mohammad Soltani, Maliheh Eftekhari, and Jalal Shiri. "High throughput mathematical modeling and multi-objective evolutionary algorithms for plant tissue culture media formulation: Case study of pear rootstocks." PLOS ONE 15, no. 12 (December 18, 2020): e0243940. http://dx.doi.org/10.1371/journal.pone.0243940.

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Simplified prediction of the interactions of plant tissue culture media components is of critical importance to efficient development and optimization of new media. We applied two algorithms, gene expression programming (GEP) and M5’ model tree, to predict the effects of media components on in vitro proliferation rate (PR), shoot length (SL), shoot tip necrosis (STN), vitrification (Vitri) and quality index (QI) in pear rootstocks (Pyrodwarf and OHF 69). In order to optimize the selected prediction models, as well as achieving a precise multi-optimization method, multi-objective evolutionary optimization algorithms using genetic algorithm (GA) and particle swarm optimization (PSO) techniques were compared to the mono-objective GA optimization technique. A Gamma test (GT) was used to find the most important determinant input for optimizing each output factor. GEP had a higher prediction accuracy than M5’ model tree. GT results showed that BA (Γ = 4.0178), Mesos (Γ = 0.5482), Mesos (Γ = 184.0100), Micros (Γ = 136.6100) and Mesos (Γ = 1.1146), for PR, SL, STN, Vitri and QI respectively, were the most important factors in culturing OHF 69, while for Pyrodwarf culture, BA (Γ = 10.2920), Micros (Γ = 0.7874), NH4NO3 (Γ = 166.410), KNO3 (Γ = 168.4400), and Mesos (Γ = 1.4860) were the most important influences on PR, SL, STN, Vitri and QI respectively. The PSO optimized GEP models produced the best outputs for both rootstocks.
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González-Sánchez, Lola, Susana Gómez-Carrasco, Alfredo Aguado, Miguel Paniagua, M. Luz Hernández, José M. Alvariño, and Octavio Roncero. "Photodetachment spectrum of OHF[sup −]: Three-dimensional study of the heavy–light–heavy resonances." Journal of Chemical Physics 121, no. 1 (2004): 309. http://dx.doi.org/10.1063/1.1756581.

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35

Jacyna, Tadeusz, Christopher J. Starbuck, and Mark R. Ellersiek. "Increasing Branching of Landscape Pear Trees With Promalin and Dikegulac-sodium." Journal of Environmental Horticulture 12, no. 2 (June 1, 1994): 90–92. http://dx.doi.org/10.24266/0738-2898-12.2.90.

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Abstract One-year-old trees of Pyrus calleryana ‘Bradford’, ‘Aristocrat’ and ‘Redspire’ on ‘OHF 97’ rootstock were treated in a nursery with foliar sprays of Promalin at 750 or 1500 ppm ai or dikegulac-sodium (Atrimmec) at 1440 or 2880 ppm ai in June 1989. Untreated trees of the three pear cultivars averaged less than one branch per tree at the end of the season, while ‘Bradford’ and ‘Aristocrat’ treated with Promalin at either concentration averaged over 10 and ‘Redspire’ averaged 9. Dikegulac promoted branching of all cultivars however, unlike Promalin, reduced tree height and resulted in visibly narrower branching angles.
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36

Nikolova, Viktoria, and Dimitar Dimanov. "ESTABLISHING APPROPRIATE PARAMETARS FOR ROOTING OF MICROPROPAGATED PEAR ROOTSTOCK OHF X 333 (PYRUS COMMUNIS L.)." Journal of Agricultural, Food and Environmental Sciences 72, no. 3 (2018): 1–5. http://dx.doi.org/10.55302/jafes18723001n.

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Elghobashi, Nadia, and Leticia González. "Breaking the strong and weak bonds of OHF−using few-cycle IR + UV laser pulses." Phys. Chem. Chem. Phys. 6, no. 16 (2004): 4071–73. http://dx.doi.org/10.1039/b409446h.

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Mortimer, Michael, Elaine A. Moore, Andrew Healy, and Neil F. Peirson. "A comparison of ab initio, NMR and diffraction results for a strong OHF hydrogen bond." Journal of Molecular Structure 271, no. 1-2 (August 1992): 149–54. http://dx.doi.org/10.1016/0022-2860(92)80217-6.

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39

Thoan, Nguyen-Hoang, Nguyen-Trung Do, Nguyen-Ngoc Trung, and Le-Van Vinh. "The structural correlation and mechanical properties in amorphous hafnium oxide under pressure." International Journal of Modern Physics B 34, no. 22n24 (August 31, 2020): 2040149. http://dx.doi.org/10.1142/s0217979220401499.

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The classical molecular dynamics (MD) technique was used to investigate the atomistic structure of amorphous hafnium oxide (HfO2) under pressure. The local atomic structure and the liquid-solid transition of HfO2 were analyzed for the pair radical distribution functions, bond angle distributions and coordination number. The simulation reveals that although the fractions of structural units HfO[Formula: see text] and OHf[Formula: see text] strongly change with the density, the partial bond angle distributions of these structural units are almost identical for all constructed models. This result has enabled us to establish a relationship between the bond angle distributions and the fractions of structural units.
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40

Deyerl, Hans-Jürgen, and Robert E. Continetti. "Photoelectron–photofragment coincidence study of OHF−: transition state dynamics of the reaction OH + F → O + HF." Phys. Chem. Chem. Phys. 7, no. 5 (2005): 855–60. http://dx.doi.org/10.1039/b414604b.

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41

Gómez-Carrasco, S., and H. Köppel. "Ab initio study of the Renner–Teller effect in the 2Π electronic state of the OHF− anion." Chemical Physics 346, no. 1-3 (May 2008): 81–88. http://dx.doi.org/10.1016/j.chemphys.2008.03.010.

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42

Nacheva, L., N. Dimitrova, and M. Berova. "Effect of LED lighting on the growth of micropropagated pear plantlets (Pyrus communis L. OHF 333)." Acta Horticulturae, no. 1337 (March 2022): 9–16. http://dx.doi.org/10.17660/actahortic.2022.1337.2.

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43

Gómez-Carrasco, Susana, Alfredo Aguado, Miguel Paniagua, and Octavio Roncero. "Transition state spectroscopy of open shell systems: Angle-resolved photodetachment spectra for the adiabatic singlet states of OHF." Journal of Photochemistry and Photobiology A: Chemistry 190, no. 2-3 (August 2007): 145–60. http://dx.doi.org/10.1016/j.jphotochem.2007.01.027.

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44

Zhao, Dan, Tian Yu Zhang, and Tian Shu Chu. "A quasi-classical trajectory (QCT) study of the H + OF reaction stereodynamics." Canadian Journal of Chemistry 88, no. 9 (September 2010): 893–97. http://dx.doi.org/10.1139/v10-063.

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Based on the global three-dimensional adiabatic potential surface of the 13A′ excited electronic state (J. Chem. Phys. 2005, 123, 114310) of the OHF system, we investigated the H + OF → OH + F/HF + O reaction stereodynamics by using the quasi-classical trajectory (QCT) method. The four polarization-dependent differential cross sections (PDDCSs) and the three angular distributions P(θr), P([Formula: see text]), P(θr, [Formula: see text]) were calculated at a low collision energy of 0.48 eV for both product channels. The results indicated that the products are backward-scattering on the triplet state, and the product rotational angular momenta are aligned or oriented. Moreover, there is a remarkable difference between the polarization behaviors of the two product channels. Product orientation exhibited by the OH + F channel is found to be absent in the HF + O channel at this collision energy albeit the latter shows stronger alignment along the direction perpendicular to the reagent relative velocity k than OH + F.
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45

Zhao, Juan. "Quasi-classical trajectory study of the O(1D) + HF reaction dynamics on 11A′ potential energy surface." Canadian Journal of Chemistry 89, no. 6 (June 2011): 650–56. http://dx.doi.org/10.1139/v11-059.

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The quasi-classical trajectory (QCT) calculations for the title reaction were carried out using the recently developed, accurate potential energy surface (PES) of the [Formula: see text] singlet state of the OHF system The integral cross section and the product rotational alignment factor [Formula: see text] were calculated as a function of collision energy. In addition, I discovered the effect of isotopic substitution on stereodynamics for the title reaction, and the influence of the rotation excitation of the reagent on stereodynamics is also presented. Both the scalar and vector properties of the reaction O(1D) + HF → OH + F(2P) are studied in this paper. It was found that the reaction is mainly controlled by an indirect reaction mechanism, and that the deep noncollinear insertion HOF well has a great impact on the dynamics of the reaction. The conclusions drawn in this paper will draw from references to similar reactions, and provide a theoretical foundation for related experiments.
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Nacheva, L. R., P. S. Gercheva, M. Y. Andonova, D. V. Panayotova, and V. T. Dzhuvinov. "SOMACLONAL VARIATION: A USEFUL TOOL TO IMPROVE DISEASE RESISTANCE OF PEAR ROOTSTOCK ¿OLD HOME × FARMINGDALE¿ (OHF 333) (PYRUS COMMUNIS L.)." Acta Horticulturae, no. 1056 (October 2014): 253–58. http://dx.doi.org/10.17660/actahortic.2014.1056.42.

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47

Dimitrova, N., V. Nikolova, and L. Nacheva. "Effect of acclimatization in a floating system on photosynthetic ability of pear plants (Pyrus communis L. OHF 333)." Acta Horticulturae, no. 1327 (November 2021): 753–62. http://dx.doi.org/10.17660/actahortic.2021.1327.101.

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48

Gong, Yu, and Mingfei Zhou. "Formation and Characterization of the Oxygen-Rich Hafnium Dioxygen Complexes: OHf(η2-O2)(η2-O3), Hf(η2-O2)3, and Hf(η2-O2)4." Journal of Physical Chemistry A 111, no. 37 (September 2007): 8973–79. http://dx.doi.org/10.1021/jp074531m.

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49

Gibertini, I., S. Cantagrel, H. Corvol, V. Tessier, and J. Laugier. "Ventilation Par Ohf Ou Vmc Des Nouveau-Nes Prematures De Moins De 30 Sa Atteints De Maladie Des Membranes Hyalines. évolution Fonctionnelle A 1 An." Archives de Pédiatrie 6 (January 1999): S514. http://dx.doi.org/10.1016/s0929-693x(99)81552-8.

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50

Obadă, B., Al O. Șerban, V. Botnaru, and Al Valcu. "The use of MRI and CT in Imaging Occult Hip Fractures." ARS Medica Tomitana 20, no. 4 (November 1, 2014): 207–10. http://dx.doi.org/10.1515/arsm-2015-0007.

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Abstract Diagnosis of hip fractures is particularly important due to the high dependence on the integrity of this structure for people to function in their daily lives. Left unrecognized, patients face increasing morbidity and mortality as time from the original injury lengthens. A delay of just 2 days in surgical treatment for an acute hip fracture doubles mortality. In addition, an unrecognized non-displaced fracture may displace, requiring surgery of much higher risk. This may be part of the reason that the most frequent lawsuit against Emergency Physicians is for missed orthopedic injury. We reviewed the use of MRI and CT for occult hip fractures (OHF) detection at a major urban trauma unit. Our study is a retrospective review. Inclusion criteria: all patients presenting to the Emergency Clinical Hospital of Constanta with a suspected, posttraumatic, occult hip fracture, over a 5 years period were included. All patients had negative initial radiographs and underwent further imaging with either CT or MRI. A total of 185 cases meeting the inclusion criteria were identified. 72 occult hip fractures were detected with both imaging modalities. Although MRI certainly enables greater image detail, in our experience both modalities are able to provide satisfactory fracture characterization. The choice of imaging should be determined by availability and indication. MRI provides superior imaging of soft tissue but is less sensitive for degenerative changes in presence of bone edema.
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