Journal articles on the topic 'Off-target assessment'
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Soltani, Nader, Maxwel C. Oliveira, Guilherme S. Alves, Rodrigo Werle, Jason K. Norsworthy, Christy L. Sprague, Bryan G. Young, Daniel B. Reynolds, Ashli Brown, and Peter H. Sikkema. "Off-target movement assessment of dicamba in North America." Weed Technology 34, no. 3 (January 31, 2020): 318–30. http://dx.doi.org/10.1017/wet.2020.17.
Full textChaudhari, Hemangi G., Jon Penterman, Holly J. Whitton, Sarah J. Spencer, Nicole Flanagan, Maria C. Lei Zhang, Elaine Huang, et al. "Evaluation of Homology-Independent CRISPR-Cas9 Off-Target Assessment Methods." CRISPR Journal 3, no. 6 (December 1, 2020): 440–53. http://dx.doi.org/10.1089/crispr.2020.0053.
Full textWang, Dan, Cuili Niu, Jingxin Han, Dejun Ma, and Zhen Xi. "Target DNA mutagenesis-based fluorescence assessment of off-target activity of the CRISPR-Cas9 system." RSC Advances 9, no. 16 (2019): 9067–74. http://dx.doi.org/10.1039/c8ra10017a.
Full textCorsi, Giulia I., Veerendra P. Gadekar, Jan Gorodkin, and Stefan E. Seemann. "CRISPRroots: on- and off-target assessment of RNA-seq data in CRISPR–Cas9 edited cells." Nucleic Acids Research 50, no. 4 (November 29, 2021): e20-e20. http://dx.doi.org/10.1093/nar/gkab1131.
Full textZhao, Hui, and Jeffrey D. Wolt. "Risk associated with off-target plant genome editing and methods for its limitation." Emerging Topics in Life Sciences 1, no. 2 (November 10, 2017): 231–40. http://dx.doi.org/10.1042/etls20170037.
Full textFischer, André, Manuel Sellner, Karolina Mitusińska, Maria Bzówka, Markus A. Lill, Artur Góra, and Martin Smieško. "Computational Selectivity Assessment of Protease Inhibitors against SARS-CoV-2." International Journal of Molecular Sciences 22, no. 4 (February 19, 2021): 2065. http://dx.doi.org/10.3390/ijms22042065.
Full textZhang, Weiwei, Jianhang Yin, Zhengrong Zhang-Ding, Changchang Xin, Mengzhu Liu, Yuhong Wang, Chen Ai, and Jiazhi Hu. "In-depth assessment of the PAM compatibility and editing activities of Cas9 variants." Nucleic Acids Research 49, no. 15 (June 16, 2021): 8785–95. http://dx.doi.org/10.1093/nar/gkab507.
Full textJefferts, Katharine, Janusz Burczynski, and William G. Pearcy. "Acoustical Assessment of Squid (Loligo opalescens) off the Central Oregon Coast." Canadian Journal of Fisheries and Aquatic Sciences 44, no. 6 (June 1, 1987): 1261–67. http://dx.doi.org/10.1139/f87-149.
Full textRao, D. D., N. Senzer, M. A. Cleary, and J. Nemunaitis. "Comparative assessment of siRNA and shRNA off target effects: what is slowing clinical development." Cancer Gene Therapy 16, no. 11 (August 28, 2009): 807–9. http://dx.doi.org/10.1038/cgt.2009.53.
Full textIvanov, P. Yu, and O. G. Mikhailova. "By-catch in the specialized fishery of target crab species near Kamchatka." Researches of the aquatic biological resources of Kamchatka and the North-West Part of the Pacific Ocean 2, no. 64 (October 9, 2022): 35–54. http://dx.doi.org/10.15853/2072-8212.2022.64.35-54.
Full textLin, Linda Yingqi, Samuele Cancellieri, Jing Zeng, Francesco Masillo, My Anh Nguyen, Nicola Bombieri, Stacy A. Maitland, et al. "Human Genetic Diversity Alters Therapeutic Gene Editing Off-Target Outcomes." Blood 138, Supplement 1 (November 5, 2021): 3993. http://dx.doi.org/10.1182/blood-2021-152429.
Full textLim, Ming Tsuey, Norazida Ab Rahman, Xin Rou Teh, Chee Lee Chan, Shantini Thevendran, Najwa Ahmad Hamdi, Ka Keat Lim, and Sheamini Sivasampu. "Optimal cut-off points for adherence measure among patients with type 2 diabetes in primary care clinics: a retrospective analysis." Therapeutic Advances in Chronic Disease 12 (January 2021): 204062232199026. http://dx.doi.org/10.1177/2040622321990264.
Full textHall, F. R., J. Cooper, L. Kirchner, R. Downer, and R. Thacker. "Assessment of off-target movement of orchard pesticides: Capture efficiencies of synthetic and biological biomarkers." Journal of Environmental Science and Health, Part B 31, no. 4 (July 1996): 815–30. http://dx.doi.org/10.1080/03601239609373038.
Full textGarrood, William T., Nace Kranjc, Karl Petri, Daniel Y. Kim, Jimmy A. Guo, Andrew M. Hammond, Ioanna Morianou, et al. "Analysis of off-target effects in CRISPR-based gene drives in the human malaria mosquito." Proceedings of the National Academy of Sciences 118, no. 22 (April 30, 2021): e2004838117. http://dx.doi.org/10.1073/pnas.2004838117.
Full textHe-Hua, Wang, Zhu Jian-Jun, Gu Xiao-Yan, and Chen Ye. "A Multiple Criteria Decision Analysis Method for Alternative Assessment Results Obeying a Particular Distribution and Application." Mathematical Problems in Engineering 2018 (2018): 1–14. http://dx.doi.org/10.1155/2018/2108726.
Full textFan, Cuiqing, Xiongwei Cai, Feng Zhang, Cindy Hochstetler, Xiaoyi Chen, Fukun Guo, Weidong Tian, and Yi Zheng. "Precision Assessment of on- and Off-Target Effects of mTOR Kinase Inhibitors in a Mouse Model." Blood 132, Supplement 1 (November 29, 2018): 2632. http://dx.doi.org/10.1182/blood-2018-99-115225.
Full textFeng, Joseph C., Dean G. Thompson, and Philip E. Reynolds. "Fate of glyphosate in a Canadian forest watershed. 1. Aquatic residues and off-target deposit assessment." Journal of Agricultural and Food Chemistry 38, no. 4 (April 1990): 1110–18. http://dx.doi.org/10.1021/jf00094a045.
Full textRusso, Monia Teresa, Riccardo Aiese Cigliano, Walter Sanseverino, and Maria Immacolata Ferrante. "Assessment of genomic changes in a CRISPR/Cas9 Phaeodactylum tricornutum mutant through whole genome resequencing." PeerJ 6 (October 5, 2018): e5507. http://dx.doi.org/10.7717/peerj.5507.
Full textAhmad, Fiaz, Songchao Zhang, Baijing Qiu, Jing Ma, Huang Xin, Wei Qiu, Shibbir Ahmed, Farman Ali Chandio, and Aftab Khaliq. "Comparison of Water Sensitive Paper and Glass Strip Sampling Approaches to Access Spray Deposit by UAV Sprayers." Agronomy 12, no. 6 (May 29, 2022): 1302. http://dx.doi.org/10.3390/agronomy12061302.
Full textMogren, Christina L., and Jonathan Gary Lundgren. "In silico identification of off-target pesticidal dsRNA binding in honey bees (Apis mellifera)." PeerJ 5 (December 13, 2017): e4131. http://dx.doi.org/10.7717/peerj.4131.
Full textBae, Taegeun, Hanseop Kim, Jeong Hee Kim, Yong Jun Kim, Seung Hwan Lee, Byung-Joo Ham, and Junho K. Hur. "Specificity Assessment of CRISPR Genome Editing of Oncogenic EGFR Point Mutation with Single-Base Differences." Molecules 25, no. 1 (December 22, 2019): 52. http://dx.doi.org/10.3390/molecules25010052.
Full textPatel, Bhavinkumar B., Carlos A. Barrero, Alan Braverman, Phillip D. Kim, Kelly A. Jones, Dian Er Chen, Russell P. Bowler, Salim Merali, Steven G. Kelsen, and Anthony T. Yeung. "Assessment of Two Immunodepletion Methods: Off-Target Effects and Variations in Immunodepletion Efficiency May Confound Plasma Proteomics." Journal of Proteome Research 11, no. 12 (October 29, 2012): 5947–58. http://dx.doi.org/10.1021/pr300686k.
Full textAhmed, Firoz, Muthappa Senthil-Kumar, Xinbin Dai, Vemanna S. Ramu, Seonghee Lee, Kirankumar S. Mysore, and Patrick Xuechun Zhao. "pssRNAit: A Web Server for Designing Effective and Specific Plant siRNAs with Genome-Wide Off-Target Assessment." Plant Physiology 184, no. 1 (July 10, 2020): 65–81. http://dx.doi.org/10.1104/pp.20.00293.
Full textPimentel, Helly, Helen Jarnagin, Hailing Zong, Courtney Todorov, Courtney M. Anderson, Bingqing Zhang, Christopher Bunker, and Xiao-Jun Ma. "Preclinical CAR-T cell target safety, biodistribution, and tumor infiltration analysis using in situ hybridization technology." Journal of Clinical Oncology 37, no. 8_suppl (March 10, 2019): 112. http://dx.doi.org/10.1200/jco.2019.37.8_suppl.112.
Full textVaillant, Andrew. "Oligonucleotide-Based Therapies for Chronic HBV Infection: A Primer on Biochemistry, Mechanisms and Antiviral Effects." Viruses 14, no. 9 (September 16, 2022): 2052. http://dx.doi.org/10.3390/v14092052.
Full textTan, E‐Pien, Yilong Li, Martin Del Castillo Velasco‐Herrera, Kosuke Yusa, and Allan Bradley. "Off‐target assessment of CRISPR ‐ C as9 guiding RNA s in human i PS and mouse ES cells." genesis 53, no. 2 (December 10, 2014): 225–36. http://dx.doi.org/10.1002/dvg.22835.
Full textRamaprasad, Jaya, Ming-Yi Tsai, Kai Elgethun, Vincent R. Hebert, Allan Felsot, Michael G. Yost, and Richard A. Fenske. "The Washington aerial spray drift study: assessment of off-target organophosphorus insecticide atmospheric movement by plant surface volatilization." Atmospheric Environment 38, no. 33 (October 2004): 5703–13. http://dx.doi.org/10.1016/j.atmosenv.2004.04.035.
Full textCancellieri, Samuele, Matthew C. Canver, Nicola Bombieri, Rosalba Giugno, and Luca Pinello. "CRISPRitz: rapid, high-throughput and variant-aware in silico off-target site identification for CRISPR genome editing." Bioinformatics 36, no. 7 (November 25, 2019): 2001–8. http://dx.doi.org/10.1093/bioinformatics/btz867.
Full textFennell, Myles, Qing Xiang, Alexia Hwang, Chong Chen, Chun-Hao Huang, Chi-Chao Chen, Raphael Pelossof, and Ralph J. Garippa. "Impact of RNA-Guided Technologies for Target Identification and Deconvolution." Journal of Biomolecular Screening 19, no. 10 (August 27, 2014): 1327–37. http://dx.doi.org/10.1177/1087057114548414.
Full textGoldmacher, Gregory V., Anuradha D. Khilnani, Robert H. I. Andtbacka, Jason J. Luke, F. Stephen Hodi, Aurelien Marabelle, Kevin Joseph Harrington, et al. "Response criteria for intratumoral immunotherapy in solid tumors: ItRECIST." Journal of Clinical Oncology 38, no. 15_suppl (May 20, 2020): 3141. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.3141.
Full textStover, Ed, Dominick Scotto, Chris Wilson, and Masoud Salyani. "Pesticide Spraying in Indian River Grapefruit: II. Overview of Factors Influencing Spray Efficacy and Off-target Deposition." HortTechnology 13, no. 1 (January 2003): 166–77. http://dx.doi.org/10.21273/horttech.13.1.0166.
Full textNazari-Shafti, Timo Z., Sebastian Neuber, Ana G. Duran, Vasileios Exarchos, Christien M. Beez, Heike Meyborg, Katrin Krüger, et al. "MiRNA Profiles of Extracellular Vesicles Secreted by Mesenchymal Stromal Cells—Can They Predict Potential Off-Target Effects?" Biomolecules 10, no. 9 (September 22, 2020): 1353. http://dx.doi.org/10.3390/biom10091353.
Full textvan Vollenhoven, Ronald, Alexandre Voskuyl, George Bertsias, Cynthia Aranow, Martin Aringer, Laurent Arnaud, Anca Askanase, et al. "A framework for remission in SLE: consensus findings from a large international task force on definitions of remission in SLE (DORIS)." Annals of the Rheumatic Diseases 76, no. 3 (November 24, 2016): 554–61. http://dx.doi.org/10.1136/annrheumdis-2016-209519.
Full textTirmenstein, Mark, Thomas E. Dorr, Evan B. Janovitz, Deborah Hagan, Lynn M. Abell, Joelle M. Onorato, Jean M. Whaley, Michael J. Graziano, and Timothy P. Reilly. "Nonclinical Toxicology Assessments Support the Chronic Safety of Dapagliflozin, a First-in-Class Sodium-Glucose Cotransporter 2 Inhibitor." International Journal of Toxicology 32, no. 5 (September 2013): 336–50. http://dx.doi.org/10.1177/1091581813505331.
Full textMensali, Nadia, Marit Renée Myhre, Pierre Dillard, Sylvie Pollmann, Gustav Gaudernack, Gunnar Kvalheim, Sébastien Wälchli, and Else Marit Inderberg. "Preclinical assessment of transiently TCR redirected T cells for solid tumour immunotherapy." Cancer Immunology, Immunotherapy 68, no. 8 (June 18, 2019): 1235–43. http://dx.doi.org/10.1007/s00262-019-02356-2.
Full textMiyake, Rina, and Hiroko Itoh. "Design and Safety Assessment of Recommended Route off the Western Coast of Izu O Shima Island." Journal of Marine Science and Engineering 10, no. 8 (August 2, 2022): 1060. http://dx.doi.org/10.3390/jmse10081060.
Full textGraham, Scott. "The Non-combatant Casualty Cut-off Value: Assessment of a Novel Targeting Technique in Operation Inherent Resolve." International Criminal Law Review 18, no. 4 (November 10, 2018): 655–85. http://dx.doi.org/10.1163/15718123-01804002.
Full textRoberts, M., S. Allen, E. Marsh, J. Clarke, and D. Coley. "Consequential impacts of a net-zero carbon design: life cycle assessment of an active building." IOP Conference Series: Earth and Environmental Science 1078, no. 1 (September 1, 2022): 012091. http://dx.doi.org/10.1088/1755-1315/1078/1/012091.
Full textOropilla, Jean Q. L., Cid C. E. Diesta, Parunut Itthimathin, Oksana Suchowersky, and Zelma H. T. Kiss. "Both thalamic and pallidal deep brain stimulation for myoclonic dystonia." Journal of Neurosurgery 112, no. 6 (June 2010): 1267–70. http://dx.doi.org/10.3171/2009.10.jns091062.
Full textWINTER, SIDNEY G. "Problems at the Foundation? Comments on Felin and Foss." Journal of Institutional Economics 7, no. 2 (January 28, 2011): 257–77. http://dx.doi.org/10.1017/s1744137410000470.
Full textAghdeab, Shukry, Ahmed G. Abdulameer, Ahmed B. Abdulwahhab, and Majid H. Ismiel. "Improve the Surface Characteristics of the Electric Discharge Machining Employing a Method Burnishing Process." Engineering and Technology Journal 38, no. 4A (April 25, 2020): 545–51. http://dx.doi.org/10.30684/etj.v38i4a.308.
Full textCoombs, Roger F., and Richard Barr. "In situ measurements of orange roughy (Hoplostethus atlanticus) target strength." ICES Journal of Marine Science 64, no. 6 (June 27, 2007): 1220–34. http://dx.doi.org/10.1093/icesjms/fsm084.
Full textJhawer, M., H. L. Kindler, Z. Wainberg, J. Ford, P. Kunz, L. Tang, S. McCallum, H. Kallender, and M. A. Shah. "Assessment of two dosing schedules of GSK1363089 (GSK089), a dual MET/VEGFR2 inhibitor, in metastatic gastric cancer (GC): Interim results of a multicenter phase II study." Journal of Clinical Oncology 27, no. 15_suppl (May 20, 2009): 4502. http://dx.doi.org/10.1200/jco.2009.27.15_suppl.4502.
Full textZhang, Yunpu, and Ganlin Shan. "A Risk-Based Multisensor Optimization Scheduling Method for Target Threat Assessment." Mathematical Problems in Engineering 2019 (August 4, 2019): 1–14. http://dx.doi.org/10.1155/2019/2043727.
Full textCiğerci, İbrahim Hakkı. "Genotoxic assessment of oxadiazon and pendimethalin herbicides on Eisenia hortensis by comet and micronucleus tests." Pakistan Journal of Agricultural Sciences 59, no. 02 (January 1, 2022): 207–11. http://dx.doi.org/10.21162/pakjas/22.9940.
Full textUrgessa, Megersso. "The Mini Nutritional Assessment tool’s applicability for the elderly in Ethiopia: validation study." PeerJ 10 (November 16, 2022): e14396. http://dx.doi.org/10.7717/peerj.14396.
Full textPunt, André E., Malcolm Haddon, L. Richard Little, and Geoffrey N. Tuck. "The effect of marine closures on a feedback control management strategy used in a spatially aggregated stock assessment: a case study based on pink ling in Australia." Canadian Journal of Fisheries and Aquatic Sciences 74, no. 11 (November 2017): 1960–73. http://dx.doi.org/10.1139/cjfas-2016-0017.
Full textZhang, Wei, Zheng Lv, Yupeng Zhang, Subash C. B. Gopinath, Yi Yuan, Deyou Huang, and Liu Miao. "Targeted Diagnosis, Therapeutic Monitoring, and Assessment of Atherosclerosis Based on Mesoporous Silica Nanoparticles Coated with cRGD-Platelets." Oxidative Medicine and Cellular Longevity 2022 (September 29, 2022): 1–19. http://dx.doi.org/10.1155/2022/6006601.
Full textGoraj, Zdobyslaw Jan, Marek Malinowski, and Andrzej Frydrychewicz. "Design of novel aerial jet target." Aircraft Engineering and Aerospace Technology 89, no. 4 (July 3, 2017): 511–19. http://dx.doi.org/10.1108/aeat-10-2016-0174.
Full textWang, Ena, Alessandra Cesano, Lisa H. Butterfield, and Francesco Marincola. "Improving the therapeutic index in adoptive cell therapy: key factors that impact efficacy." Journal for ImmunoTherapy of Cancer 8, no. 2 (October 2020): e001619. http://dx.doi.org/10.1136/jitc-2020-001619.
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