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1
Kerekes, Amália. Mehr oder Weininger: Eine Textoffensive aus Österreich/Ungarn. Wien: Braumüller, 2005.
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2
Fattahi, Mir Taher. Emil Abderhalden (1877-1950), die Abwehrfermente: Ein langer Irrweg oder wissenschaftlicher Betrug? Berlin: Uni-Edition, 2006.
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3
Issel, Wolfgang. Die Wiederaurarbeitung von bestrahlten Kernbrennstoffen in der Bundesrepublik Deutschland: Technologische Chance oder energiepolitischer Zwang. Frankfurt am Main: P. Lang, 2003.
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4
Henriksen, Niels Engholm, and Flemming Yssing Hansen. Bimolecular Reactions, Dynamics of Collisions. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780198805014.003.0004.
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This chapter discusses the dynamics of bimolecular collisions within the framework of (quasi-)classical mechanics as well as quantum mechanics. The relation between the cross-section and the reaction probability, which can be calculated theoretically from a (quasi-)classical or quantum mechanical description of the collision, is described in terms of classical trajectories and wave packets, respectively. As an introduction to reactive scattering, classical two-body scattering is described and used to formulate simple models for chemical reactions, based on reasonable assumptions for the reaction probability. Three-body (and many-body) quasi-classical scattering is formulated and the numerical evaluation of the reaction probability is described. The relation between scattering angles and differential cross-sections in various frames is emphasized. The chapter concludes with a brief description of non-adiabatic dynamics, that is, situations beyond the Born–Oppenheimer approximation where more than one electronic state is in play. A discussion of the so-called Landau–Zener model is included.
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Wiffen, Philip, Marc Mitchell, Melanie Snelling, and Nicola Stoner. Adverse drug reactions and drug interactions. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780198735823.003.0002.
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This chapter provides an overview of adverse drug reactions and drug interactions for pharmacists and other healthcare professionals. It provides a practical guide to determining whether a reaction is related to the drug or disease. A classification of adverse drug reactions is given and how this relates to immediate management of the reaction and future drug choices is discussed. Tips are given on how to discuss adverse drug reactions and explain risks to patients. Mechanisms of drug interactions are covered and a practical guide for predicting and managing interactions is given.
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Henriksen, Niels Engholm, and Flemming Yssing Hansen. From Microscopic to Macroscopic Descriptions. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780198805014.003.0002.
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This chapter discusses bimolecular reactions from both a microscopic and macroscopic point of view. The outcome of an isolated reactive scattering event can be specified in terms of an intrinsic fundamental quantity, the reaction cross-section that can be measured in a molecular beam experiment. It depends on the quantum states of the molecules as well as the relative velocity of reactants and products. The relation between the cross-section and the macroscopic rate constant is derived. The rate constant is a weighted average of the product between the relative speed of the reactants and the reaction cross-section. The chapter concludes with the special case of thermal equilibrium, where the velocity distributions for the molecules are the Maxwell–Boltzmann distribution. The expression for the rate constant at temperature T is reduced to a one-dimensional integral over the relative speed of the reactants.
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Ferner, Robin, and Anthony Cox. Drug-induced neurological disease. Edited by Patrick Davey and David Sprigings. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199568741.003.0240.
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An adverse drug reaction is defined as ‘an appreciably harmful or unpleasant reaction, resulting from an intervention related to the use of a medicinal product; adverse effects usually predict hazard from future administration and warrant prevention, or specific treatment, or alteration of the dosage regimen, or withdrawal of the product’ (p. 1255, Edwards IR and Aronson JK. Adverse drug reactions: Definitions, diagnosis, and management. Lancet 2000; 356: 1255–9). Adverse drug reactions can cause or contribute to central and peripheral nervous system disorders, including traumatic, infective, neoplastic, demyelinating, and vascular diseases.
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Misbah, Siraj. Suspected anaphylaxis. Edited by Patrick Davey and David Sprigings. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199568741.003.0075.
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A type I IgE-mediated systemic allergic reaction is characterized by a constellation of symptoms which are due to widespread histamine release and which comprise acute-onset urticaria, angioedema, bronchospasm, and hypotension. While a mild reaction may be limited to localized urticaria and/or angioedema, a full-blown allergic reaction associated with systemic features is best described as anaphylaxis. The term ‘anaphylactoid’, previously used to denote non-IgE-mediated systemic allergic reactions, is no longer recommended for use.
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Henriksen, Niels E., and Flemming Y. Hansen. Theories of Molecular Reaction Dynamics. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780198805014.001.0001.
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This book deals with a central topic at the interface of chemistry and physics—the understanding of how the transformation of matter takes place at the atomic level. Building on the laws of physics, the book focuses on the theoretical framework for predicting the outcome of chemical reactions. The style is highly systematic with attention to basic concepts and clarity of presentation. Molecular reaction dynamics is about the detailed atomic-level description of chemical reactions. Based on quantum mechanics and statistical mechanics or, as an approximation, classical mechanics, the dynamics of uni- and bimolecular elementary reactions are described. The first part of the book is on gas-phase dynamics and it features a detailed presentation of reaction cross-sections and their relation to a quasi-classical as well as a quantum mechanical description of the reaction dynamics on a potential energy surface. Direct approaches to the calculation of the rate constant that bypasses the detailed state-to-state reaction cross-sections are presented, including transition-state theory, which plays an important role in practice. The second part gives a comprehensive discussion of basic theories of reaction dynamics in condensed phases, including Kramers and Grote–Hynes theory for dynamical solvent effects. Examples and end-of-chapter problems are included in order to illustrate the theory and its connection to chemical problems. The book has ten appendices with useful details, for example, on adiabatic and non-adiabatic electron-nuclear dynamics, statistical mechanics including the Boltzmann distribution, quantum mechanics, stochastic dynamics and various coordinate transformations including normal-mode and Jacobi coordinates.
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Ross, John, Igor Schreiber, and Marcel O. Vlad. Determination of Complex Reaction Mechanisms. Oxford University Press, 2006. http://dx.doi.org/10.1093/oso/9780195178685.001.0001.
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In a chemical system with many chemical species several questions can be asked: what species react with other species: in what temporal order: and with what results? These questions have been asked for over one hundred years about simple and complex chemical systems, and the answers constitute the macroscopic reaction mechanism. In Determination of Complex Reaction Mechanisms authors John Ross, Igor Schreiber, and Marcel Vlad present several systematic approaches for obtaining information on the causal connectivity of chemical species, on correlations of chemical species, on the reaction pathway, and on the reaction mechanism. Basic pulse theory is demonstrated and tested in an experiment on glycolysis. In a second approach, measurements on time series of concentrations are used to construct correlation functions and a theory is developed which shows that from these functions information may be inferred on the reaction pathway, the reaction mechanism, and the centers of control in that mechanism. A third approach is based on application of genetic algorithm methods to the study of the evolutionary development of a reaction mechanism, to the attainment given goals in a mechanism, and to the determination of a reaction mechanism and rate coefficients by comparison with experiment. Responses of non-linear systems to pulses or other perturbations are analyzed, and mechanisms of oscillatory reactions are presented in detail. The concluding chapters give an introduction to bioinformatics and statistical methods for determining reaction mechanisms.
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Doraiswamy, L. K. Organic Synthesis Engineering. Oxford University Press, 2001. http://dx.doi.org/10.1093/oso/9780195096897.001.0001.
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This book will formally launch "organic synthesis engineering" as a distinctive field in the armory of the reaction engineer. Its main theme revolves around two developments: catalysis and the role of process intensification in enhancing overall productivity. Each of these two subjects are becoming increasingly useful in organic synthesis engineering, especially in the production of medium and small volume chemicals and enhancing reaction rates by extending laboratory techniques, such as ultrasound, phase transfer catalysts, membrane reactor, and microwaves, to industrial scale production. This volume describes the applications of catalysis in organic synthesis and outlines different techniques of reaction rate and/or selectivity enhancement against a background of reaction engineering principles for both homogeneous and heterogeneous systems.
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Tutino, Stefania. The Roman Reaction. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780190694098.003.0006.
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During the central decades of the seventeenth century, Caramuel’s understanding of probabilism was the object of both acute interest and widespread, and at times violent, criticism. As a result, the Congregation of the Index of Prohibited Book and the Holy Office decided to examine and eventually censure two of Caramuel’s most influential works. Through an analysis of the lengthy process leading to the censure and correction of these books, this chapter examines the theological, intellectual, moral, and political issues at stake in the debate over Caramuel’s doctrine and explores the complex and ambivalent way in which the institutional and theological center of the Catholic Church responded to probabilism.
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Atkins, Peter. Reactions. Oxford University Press, 2011. http://dx.doi.org/10.1093/oso/9780199695126.001.0001.
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Illustrated with remarkable new full-color images--indeed, one or more on every page--and written by one of the world's leading authorities on the subject, Reactions offers a compact, pain-free tour of the inner workings of chemistry. Reactions begins with the chemical formula almost everyone knows--the formula for water, H2O--a molecule with an "almost laughably simple chemical composition." But Atkins shows that water is also rather miraculous--it is the only substance whose solid form is less dense than its liquid (hence ice floats in water)--and incredibly central to many chemical reactions, as it is an excellent solvent, being able to dissolve gases and many solids. Moreover, Atkins tells us that water is actually chemically aggressive, and can react with and destroy the compounds dissolved in it, and he shows us what happens at the molecular level when water turns to ice--and when it melts. Moving beyond water, Atkins slowly builds up a toolkit of basic chemical processes, including precipitation (perhaps the simplest of all chemical reactions), combustion, reduction, corrosion, electrolysis, and catalysis. He then shows how these fundamental tools can be brought together in more complex processes such as photosynthesis, radical polymerization, vision, enzyme control, and synthesis. Peter Atkins is the world-renowned author of numerous best-selling chemistry textbooks for students. In this crystal-clear, attractively illustrated, and insightful volume, he provides a fantastic introductory tour--in just a few hundred colorful and lively pages - for anyone with a passing or serious interest in chemistry.
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Baer, Tomas, and William L. Hase. Unimolecular Reaction Dynamics. Oxford University Press, 1996. http://dx.doi.org/10.1093/oso/9780195074949.001.0001.
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This book provides a penetrating and comprehensive description of energy selected reactions from a theoretical as well as experimental view. Three major aspects of unimolecular reactions involving the preparation of the reactants in selected energy states, the rate of dissociation of the activated molecule, and the partitioning of the excess energy among the final products, are fully discussed with the aid of 175 illustrations and over 1,000 references, most from the recent literature. Examples of both neutral and ionic reactions are presented. Many of the difficult topics are discussed at several levels of sophistication to allow access by novices as well as experts. Among the topics covered for the first time in monograph form is a discussion of highly excited vibrational/rotational states and intramolecular vibrational energy redistribution. Problems associated with the application of RRKM theory are discussed with the aid of experimental examples. Detailed comparisons are also made between different statistical models of unimolecular decomposition. Both quantum and classical models not based on statistical assumptions are described. Finally, a chapter devoted to the theory of product energy distribution includes the application of phase space theory to the dissociation of small and large clusters. The work will be welcomed as a valuable resource by practicing researchers and graduate students in physical chemistry, and those involved in the study of chemical reaction dynamics.
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Clarke, Andrew. Temperature and reaction rate. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780199551668.003.0007.
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All other things being equal, physiological reaction rate increases roughly exponentially with temperature. Organisms that have adapted over evolutionary time to live at different temperatures can have enzyme variants that exhibit similar kinetics at the temperatures to which they have adapted to operate. Within species whose distribution covers a range of temperatures, there may be differential expression of enzyme variants with different kinetics across the distribution. Enzymes adapted to different optimum temperatures differ in their amino acid sequence and thermal stability. The Gibbs energy of activation tends to be slightly lower in enzyme variants adapted to lower temperatures, but the big change is a decrease in the enthalpy of activation, with a corresponding change in the entropy of activation, both associated with a more open, flexible structure. Despite evolutionary adjustments to individual enzymes involved in intermediary metabolism (ATP regeneration), many whole-organism processes operate faster in tropical ectotherms compared with temperate or polar ectotherms. Examples include locomotion (muscle power output), ATP regeneration (mitochondrial function), nervous conduction and growth.
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Frey, Perry A., and Adrian D. Hegeman. Enzymatic Reaction Mechanisms. Oxford University Press, 2007. http://dx.doi.org/10.1093/oso/9780195122589.001.0001.
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Books dealing with the mechanisms of enzymatic reactions were written a generation ago. They included volumes entitled Bioorganic Mechanisms, I and II by T.C. Bruice and S.J. Benkovic, published in 1965, the volume entitled Catalysis in Chemistry and Enzymology by W.P. Jencks in 1969, and the volume entitled Enzymatic Reaction Mechanisms by C.T. Walsh in 1979. The Walsh book was based on the course taught by W.P. Jencks and R.H. Abeles at Brandeis University in the 1960's and 1970's. By the late 1970's, much more could be included about the structures of enzymes and the kinetics and mechanisms of enzymatic reactions themselves, and less emphasis was placed on chemical models. Walshs book was widely used in courses on enzymatic mechanisms for many years. Much has happened in the field of mechanistic enzymology in the past 15 to 20 years. Walshs book is both out-of-date and out-of-focus in todays world of enzymatic mechanisms. There is no longer a single volume or a small collection of volumes to which students can be directed to obtain a clear understanding of the state of knowledge regarding the chemicals mechanisms by which enzymes catalyze biological reactions. There is no single volume to which medicinal chemists and biotechnologists can refer on the subject of enzymatic mechanisms. Practitioners in the field have recognized a need for a new book on enzymatic mechanisms for more than ten years, and several, including Walsh, have considered undertaking to modernize Walshs book. However, these good intentions have been abandoned for one reason or another. The great size of the knowledge base in mechanistic enzymology has been a deterrent. It seems too large a subject for a single author, and it is difficult for several authors to coordinate their work to mutual satisfaction. This text by Perry A. Frey and Adrian D. Hegeman accomplishes this feat, producing the long-awaited replacement for Walshs classic text.
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Williams, J., RA Hook, and HL Gascoigne, eds. Farming Action: Catchment Reaction. CSIRO Publishing, 1998. http://dx.doi.org/10.1071/9780643104990.
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Dryland farming is a major export earner for many temperate-zone countries, yet it continues to degrade a country's natural resources. Effects are not restricted to the land - changes in water quality can reduce the potential uses of water and bring about catastrophic changes in both freshwater and coastal ecosystems.
Farming Action: Catchment Reaction provides a comprehensive technical overview of the relationships between dryland farming systems and catchment land and water quality in Australia, and integrates it in a whole system framework. It deals with the issues in terms of people, pointers, processes and prediction as it discusses social aspects of developing and implementing research to improve dryland farming systems in catchment management programs, indicators of catchment health, and the processes which determine the impact of the farming action on the catchment response. It concludes by considering the adequacy of our ability to use this process knowledge in models to predict the effect of dryland farming on catchment condition.
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Atherstone, Andrew. Protestant Reactions. Edited by Stewart J. Brown, Peter Nockles, and James Pereiro. Oxford University Press, 2017. http://dx.doi.org/10.1093/oxfordhb/9780199580187.013.12.
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Protestantism was a major rallying cry during the Tractarian controversies. It was anathematized by some Oxford Movement radicals as a ‘heresy’, and held tenaciously by evangelical campaigners as ‘the pure Gospel of Christ’. Protestant polemicists decried Tractarianism as a revival of Roman Catholicism in an Anglican disguise and called their brothers-in-arms to fight the theological battles of the Reformation over again. Focusing on the events in Oxford itself between 1838 and 1846, this chapter surveys the rhetoric which surrounded three overlapping themes—Protestant Reformers, Protestant Formularies, and Protestant Truth. It shows how these loomed large in the speeches and writings of those who wanted to defend the Protestant hegemony of the Church of England and the University of Oxford.
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Hopkins, Philip M. Adverse drug reactions in anaesthesia. Edited by Michel M. R. F. Struys. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199642045.003.0022.
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Adverse drug reactions are implicated in more than 40% of anaesthesia-related deaths. Undoubtedly, many more patients experience morbidity from adverse drug reactions. Widely cited definitions of adverse drug reactions encompass common side-effects but this chapter focuses on those that are unexpected reactions to drugs administered by anaesthetists and that occur at normal drug doses. The chapter includes a comprehensive account of malignant hyperthermia, which remains a major contributor to anaesthesia related to deaths. Malignant hyperthermia is a pharmacogenetic condition triggered by potent inhalational anaesthetics and possibly also suxamethonium. The genetic basis, pathophysiology, clinical presentations, and management of malignant hyperthermia are discussed. The chapter covers two other pharmacogenetic conditions: the acute porphyrias and butyrylcholinesterase (plasma cholinesterase) deficiency. Drug-induced anaphylaxis is another cause of perioperative morbidity and mortality. Recent data indicate that anaphylaxis during anaesthesia may be much more common than previously thought. The other type of adverse drug reaction covered in the chapter is serotonin syndrome. Perioperative serotonin syndrome is most likely to occur when patients who are already taking serotonergic drugs, such as selective serotonin reuptake inhibitor antidepressants or ‘triptan’ antimigraine treatments, are given a second drug with serotonergic properties, such as tramadol.
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Hitlin, Steven, and Sarah K. Harkness. The Theory of Inequality and Moral Emotions. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780190465407.003.0006.
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This chapter brings together the strands of theory and research discussed previously to introduce our theory on inequality and morality. The general argument is that in societies with greater economic inequality, the negative sanctioning-based moral emotions of anger, contempt, disgust, shame, and the like will be more frequent and severe. Societies with lower levels of inequality will conversely normalize and exhibit the more positive moral emotions of self-transcendence (compassion, praise, and empathy). Inequality thus begets negative moral emotions. These various emotional reactions to moral events not only affect everyday interaction, but also overlap with criminal justice systems’ reactions to those who offend societies’ moral codes. The more negative the moral reaction in a society, the more likely events are to prompt feelings associated with condemning others, the more the criminal justice system will be similarly focused on sanctioning as opposed to rehabilitation.
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Fox, Raymond. The Use of Self. Oxford University Press, 2011. http://dx.doi.org/10.1093/oso/9780190616144.001.0001.
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This monograph presents recent advances in neural network (NN) approaches and applications to chemical reaction dynamics. Topics covered include: (i) the development of ab initio potential-energy surfaces (PES) for complex multichannel systems using modified novelty sampling and feedforward NNs; (ii) methods for sampling the configuration space of critical importance, such as trajectory and novelty sampling methods and gradient fitting methods; (iii) parametrization of interatomic potential functions using a genetic algorithm accelerated with a NN; (iv) parametrization of analytic interatomic potential functions using NNs; (v) self-starting methods for obtaining analytic PES from ab inito electronic structure calculations using direct dynamics; (vi) development of a novel method, namely, combined function derivative approximation (CFDA) for simultaneous fitting of a PES and its corresponding force fields using feedforward neural networks; (vii) development of generalized PES using many-body expansions, NNs, and moiety energy approximations; (viii) NN methods for data analysis, reaction probabilities, and statistical error reduction in chemical reaction dynamics; (ix) accurate prediction of higher-level electronic structure energies (e.g. MP4 or higher) for large databases using NNs, lower-level (Hartree-Fock) energies, and small subsets of the higher-energy database; and finally (x) illustrative examples of NN applications to chemical reaction dynamics of increasing complexity starting from simple near equilibrium structures (vibrational state studies) to more complex non-adiabatic reactions. The monograph is prepared by an interdisciplinary group of researchers working as a team for nearly two decades at Oklahoma State University, Stillwater, OK with expertise in gas phase reaction dynamics; neural networks; various aspects of MD and Monte Carlo (MC) simulations of nanometric cutting, tribology, and material properties at nanoscale; scaling laws from atomistic to continuum; and neural networks applications to chemical reaction dynamics. It is anticipated that this emerging field of NN in chemical reaction dynamics will play an increasingly important role in MD, MC, and quantum mechanical studies in the years to come.
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Raff, Lionel, Ranga Komanduri, Martin Hagan, and Satish Bukkapatnam. Neural Networks in Chemical Reaction Dynamics. Oxford University Press, 2012. http://dx.doi.org/10.1093/oso/9780199765652.001.0001.
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This monograph presents recent advances in neural network (NN) approaches and applications to chemical reaction dynamics. Topics covered include: (i) the development of ab initio potential-energy surfaces (PES) for complex multichannel systems using modified novelty sampling and feedforward NNs; (ii) methods for sampling the configuration space of critical importance, such as trajectory and novelty sampling methods and gradient fitting methods; (iii) parametrization of interatomic potential functions using a genetic algorithm accelerated with a NN; (iv) parametrization of analytic interatomic potential functions using NNs; (v) self-starting methods for obtaining analytic PES from ab inito electronic structure calculations using direct dynamics; (vi) development of a novel method, namely, combined function derivative approximation (CFDA) for simultaneous fitting of a PES and its corresponding force fields using feedforward neural networks; (vii) development of generalized PES using many-body expansions, NNs, and moiety energy approximations; (viii) NN methods for data analysis, reaction probabilities, and statistical error reduction in chemical reaction dynamics; (ix) accurate prediction of higher-level electronic structure energies (e.g. MP4 or higher) for large databases using NNs, lower-level (Hartree-Fock) energies, and small subsets of the higher-energy database; and finally (x) illustrative examples of NN applications to chemical reaction dynamics of increasing complexity starting from simple near equilibrium structures (vibrational state studies) to more complex non-adiabatic reactions. The monograph is prepared by an interdisciplinary group of researchers working as a team for nearly two decades at Oklahoma State University, Stillwater, OK with expertise in gas phase reaction dynamics; neural networks; various aspects of MD and Monte Carlo (MC) simulations of nanometric cutting, tribology, and material properties at nanoscale; scaling laws from atomistic to continuum; and neural networks applications to chemical reaction dynamics. It is anticipated that this emerging field of NN in chemical reaction dynamics will play an increasingly important role in MD, MC, and quantum mechanical studies in the years to come.
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Elements, Compounds and Mixtures and Chemical Reactions: OCR Gateway GCSE Chemistry. HarperCollins Publishers Limited, 2016.
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24
Jordan, Robert B. Reaction Mechanisms of Inorganic and Organometallic Systems. Oxford University Press, 2007. http://dx.doi.org/10.1093/oso/9780195301007.001.0001.
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This third edition retains the general level and scope of earlier editions, but has been substantially updated with over 900 new references covering the literature through 2005, and 140 more pages of text than the previous edition. In addition to the general updating of materials, there is new or greatly expanded coverage of topics such as Curtin-Hammett conditions, pressure effects, metal hydrides and asymmetric hydrogenation catalysts, the inverted electron-transfer region, intervalence electron transfer, photochemistry of metal carbonyls, methyl transferase and nitric oxide synthase. The new chapter on heterogeneous systems introduces the basic background to this industrially important area. The emphasis is on inorganic examples of gas/liquid and gas/liquid/solid systems and methods of determining heterogeneity.
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Puntis, John. Food allergy. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198759928.003.0019.
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Food allergy is an immune response to food that can be classified as immunoglobulin (Ig)-E and non-IgE mediated. Milk, egg, peanut, tree nuts, and fish are among the most prevalent causes of food allergy. Mild reactions can include itchy rash, watering eyes, and nasal congestion while a severe reaction results in anaphylaxis. A detailed clinical history is essential when making a diagnosis, and skin prick testing and quantitative measurement of food-specific IgE antibodies can be helpful. Cow milk protein allergy causes a plethora of symptoms and frequently resolves spontaneously over the first 2 years of life; diagnosis is based mainly on clinical history. Food challenges have a pivotal role in the diagnosis of food allergy. Introduction of ‘allergic’ foods at 3–6 months alongside continuing breastfeeding may prevent allergy.
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Gumuz and highland resettlers: differing strategies of livelihood and ethnic reaction in Metekel, Northwestern Ethiopia. M unster: Lit Verlag, 2005.
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27
Brownstein, Michael. Perception, Emotion, Behavior, and Change. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780190633721.003.0002.
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This chapter describes the four components of unplanned spontaneous inclinations. These are (1) noticing a salient Feature in the ambient environment; (2) feeling an immediate, directed, and affective Tension; (3) reacting Behaviorally; and (4) moving toward Alleviation of that tension in such a way that one’s spontaneous reactions can improve over time. Noticing a salient feature (F), in other words, sets a relatively automatic process in motion, involving co-activating particular feelings (T) and behaviors (B) that either will or will not diminish over time (A), depending on the success of the action. The interaction of FTBA components is described in terms of recent debates about the contents of perception, affective representation, and model-free and model-based evaluative learning.
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Richebé, Philippe, and Cyril Rivat. The effects of morphine on the CNS. Edited by Paul Farquhar-Smith, Pierre Beaulieu, and Sian Jagger. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198834359.003.0017.
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The 1973 paper by Jacquet and Lajtha, was a pivotal report in understanding the effects of opioids on nociception, as it investigated the effects of morphine on different brain structures. To do this, the authors used a microinjection technique that allowed them to specifically target subcortical sites. The animals used in this study were rats, and evaluation of the nociceptive threshold was based on the behavioural reaction to electrical shock. Two reactions were evaluated: flinch or jump responses. The main result was that, depending on the dose and the site of injection, morphine produced either an increase in nociceptive threshold (analgesia), or a decrease in the nociceptive threshold (hyperalgesia). The authors also reported severe effects characterized by hyper-reactivity and violent uncontrolled jumping in stereotyped circular leaps when morphine was administered in the periaqueductal grey matter.
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Spilsbury, Richard. Chemical Reactions: Investigating an Industrial Accident. Heinemann-Raintree, 2013.
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Spilsbury, Richard. Chemical Reactions: Investigating an Industrial Accident. Heinemann-Raintree, 2013.
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Brommelhoff, Jessica A. Depression in Dementia Syndromes. Edited by C. Steven Richards and Michael W. O'Hara. Oxford University Press, 2013. http://dx.doi.org/10.1093/oxfordhb/9780199797004.013.007.
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Depressive symptoms are common in many dementia syndromes, and depressive disorders are much more common in older adults with dementia than in cognitively intact older adults. Depression may be a risk factor for, or a prodromal feature of, subsequent dementia. Several neuropathological mechanisms have been suggested to explain these relationships, including the role of underlying cerebrovascular risk factors for depression and cognitive impairment. Depression also may be present in dementia as an emotional reaction to cognitive decline, or as a recurrence of early and midlife depression. Differential diagnosis between depression and dementia is essential, but complicated by problems in assessment, overlapping symptoms between the two conditions, and other medical co-morbidities. Pharmacological treatment of depression in dementia may also be complicated by medical co-morbidity, and can run the risk for adverse reactions or interactions between medications. Psychotherapy and psychosocial interventions, however, hold some promise for effective reduction of depressive symptoms.
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Henriksen, Niels Engholm, and Flemming Yssing Hansen. Static Solvent Effects, Transition-State Theory. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780198805014.003.0010.
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This chapter discusses static solvent effects on the rate constant for chemical reactions in solution. It starts with a brief discussion of the thermodynamic formulation of transition-state theory. The static equilibrium structure of the solvent will modify the potential energy surface for the chemical reaction. This effect is analyzed within the framework of transition-state theory. The rate constant is expressed in terms of the potential of mean force at the activated complex. Various definitions of this potential and their relations to n-particle- and pair-distribution functions are considered. The potential of mean force may, for example, be defined such that the gradient of the potential gives the average force on an atom in the activated complex, Boltzmann averaged over all configurations of the solvent. It concludes with a discussion of a relation between the rate constants in the gas phase and in solution.
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American reactions to Indonesia's role in the Belgrade Conference. Jakarta: Equinox Pub., 2009.
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Carey, Patrick W. Sin, Repentance, and Confession in Nineteenth-Century American Protestant Polemics. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780190889135.003.0004.
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This chapter describes the American Protestant reactions to the Catholic understanding of sacramental confession. That reaction is analyzed within the context of the heritage of the Protestant Reformation’s understandings of sin, repentance, and confession. The chapter demonstrates how the Protestant Episcopal Church in the late eighteenth century and American Lutherans in the early nineteenth century transformed the inherited Anglican and Lutheran traditions on the confession of sins to a priest or pastor. In the nineteenth century, sacramental confession became a central polemic issue, because for American Protestants that doctrine seemed to violate the Protestant understanding of justification by faith alone. The Protestant polemic was based on biblical, theological, legal, disciplinary, and historical issues. But, in some cases, the polemic made sensational charges on the immoral and evil political and social consequences of the practice of sacramental confession. Salacious accounts of confessional practice became a part of the polemical record.
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Hardt, Heidi. A Reactive Culture. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780190672171.003.0007.
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Chapter 7 explains why NATO’s institutional memory continues to develop in the way that it does – despite formal learning processes being underutilized. Findings in this chapter draw on the author’s survey-based interviews with 120 NATO elites. The chapter begins by arguing that NATO’s organizational culture locks-in elites’ preference for relying on informal processes and avoiding formal processes. Key characteristics of NATO’s culture posed challenges for identifying and reporting strategic errors. The organization’s norm of consensus made formal agreements on past strategic errors difficult. Moreover, NATO’s focus on reaction over retrospection and a broader culture of blame aversion provided elites with little incentive to break the tradition of reliance on informal processes for memory development. Elites described feeling continuous pressure to react to the crisis at hand and treat past crises as unique – leaving little reason to invest in learning from past failures.
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Wiffen, Philip, Marc Mitchell, Melanie Snelling, and Nicola Stoner. Adverse drug reactions and drug interactions. Oxford University Press, 2012. http://dx.doi.org/10.1093/med/9780199603640.003.0002.
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Introduction to ADRs 14Classification of ADRs 15Adverse reactions: drug or disease? 16Helping patients understand the risk of ADRs 17Reporting ADRs 18Drug interactions 20Managing drug interactions 23Adverse drug reactions (ADRs), also known as ‘side effects’, ‘adverse drug events’, or ‘drug misadventures’, are a frequent cause of morbidity in hospital and the community. They have a significant cost both financially and in terms of quality of life. Few studies of ADRs have been carried out in the community so the effect on primary care is harder to assess, but studies in the hospital environment have shown the following. ...
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Kraus, Alfred. Reaction and development of manic and melancholic-depressive patients. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199609253.003.0018.
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The significance of Jaspers’ differentiation of the notions of reaction and development in his General Psychopathology is shown by clinical examples of manic and melancholic as well as bipolar disturbances. Supplemented by his concepts of “situation” and “comprehensibility” the relevance of all these concepts for diagnostic classification, development and symptomatology of these states is demonstrated and discussed. These issues are compared with extended modern empirical and psychopathological research, in particular that on the personality structure of these patients. The results are brought in connection with Jaspers’ important concepts of the antinomic structure of human being, borderline situation and sc. “Gehäuse” in order to deepen our understanding of the clinical states of melancholia and mania on the background of the identity structure of these patients.
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Westlund, Andrea C. Answerability without Blame? Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780190609610.003.0011.
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Widely derided by popular psychologists as a destructive response, blame has many defenders among contemporary philosophers. The chapter pushes against their defenses of blame by distinguishing between blame as a reactive attitude and blaming as a speech act, arguing that some disagreement over blame’s value can be explained by the fact that blaming, as a speech act, takes several different forms. Critiques of blame properly target judgmental or strongly verdictive blaming, which treats the wrongdoer as deserving of the blamer’s hostile reactions. This tends to foreclose engagement in further moral dialogue with wrongdoers—an effect particularly destructive in therapeutic contexts; here, it is often more appropriate and constructive to hold others answerable without blaming them in the strongly verdictive sense. The chapter argues that such blame may be similarly destructive outside of straightforwardly therapeutic contexts, and challenges the existence of a sharp divide between therapeutic and nontherapeutic responses to wrongdoers.
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Helm, Bennett W. Trust: A Forward-Looking Reactive Attitude. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780198801863.003.0004.
Full textAbstract:
The reactive attitudes are often thought to be “reactive” in that they are backward-looking responses to wrongdoing that has already happened. This is a mistake that obscures the rational interconnections among the reactive attitudes. Rather, we should understand trust and distrust to be forward-looking reactive attitudes, so that in feeling trust we are thereby committed to later feeling approbation or gratitude when our trust is upheld or resentment when it is betrayed. Understanding trust in this way not only clarifies the rational interconnections among reactive attitudes. It also provides a compelling account of trust itself, including: the nature of trustworthiness and the rationality of trust; distinctions among personal, self, and vicarious reactive trust; the nature of welcome and unwelcome trust; and how trust can motivate the trustee to act in accordance with that trust. The Chapter concludes by helpfully blurring the distinction between emotions and evaluative judgments.
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Goode, Erich. The Taming of New York's Washington Square. NYU Press, 2018. http://dx.doi.org/10.18574/nyu/9781479878574.001.0001.
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This book addresses the matter of how social audiences, both formal agents of social control (the NYPD and the Park Enforcement Control) and the ordinary, everyday park-goer, react when they encounter what they consider wrongdoing, or “deviance.” The focus is on the micro or face-to-face interactional level; the larger structural forces are held in abeyance and assumed to operate, but they are not analysed or accounted for here. Likewise, literary and philosophical speculations as well as considering political and ideological implications have been left to other analysts. What constitutes deviance in an unconventional public setting remains the central issue throughout the volume. Visitors to the park—one that is known for celebrating difference and diversity—observe behaviour or utterances by an actor or a speaker in their presence that, they feel goes too far in violating their sense of acceptable norms. What do they do? How do they sanction the offender? The analysis in this book presents the reader with a series of anecdotes—events or episodes observed or statements overheard by the researcher that audiences, judging by their reactions, consider untoward. The action-reaction-interaction dynamics constitutes the lodestone of this volume. Washington Square Park is a “text”; this book represents a sociological “reading” of that text.
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Thomas, Emily. Later British Reactions to Absolutism: 1690–1704. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780198807933.003.0009.
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This chapter considers British reactions to absolutism between the 1690 publication of Locke’s Essay and the 1704 delivery of Clarke’s Boyle lectures. These reactions tended to focus on absolutism about space rather than time, and they were extremely mixed. Thinkers such as William King, Joseph Raphson, Richard Bentley, and John Keill adopt absolutism about time, duration, or space. Their absolutisms draw on various sources, including Gassendi, Henry More, and Newton. Of these absolutisms, the Newtonian strain would prove the most influential. In contrast to these early advocates, thinkers such as Richard Burthogge, John Sergeant, and John Toland reject absolutism, advancing a variety of metaphysical and theological worries.
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Deigh, John. Reactive Attitudes Revisited: A Modest Revision. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780190878597.003.0006.
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The essay offers an interpretation of P. F. Strawson’s “Freedom and Resentment” on which attributions of moral responsibility presuppose a practice of holding people morally responsible for their actions, and what explains the practice is our liability to such reactive attitudes as resentment and indignation. The interpretation is offered to correct a common misinterpretation of Strawson’s essay. On this common misinterpretation, attributions of moral responsibility are implicit in the reactive attitudes of resentment and indignation, and consequently our liability to these attitudes cannot explain these attributions. The reason this is a misinterpretation of Strawson’s essay is that Strawson’s compatibilist solution to the free will problem requires that our liability to the reactive attitudes be conceptually prior to our attributions of moral responsibility.
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Billing, Gert D., ed. The Quantum Classical Theory. Oxford University Press, 2003. http://dx.doi.org/10.1093/oso/9780195146196.001.0001.
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Over a period of fifty years, the quantum-classical or semi-classical theories have been among the most popular for calculations of rates and cross sections for many dynamical processes: energy transfer, chemical reactions, photodissociation, surface dynamics, reactions in clusters and solutions, etc. These processes are important in the simulation of kinetics of processes in plasma chemistry, chemical reactors, chemical or gas lasers, atmospheric and interstellar chemistry, as well as various industrial processes. This book gives an overview of quantum-classical methods that are currently used for a theoretical description of these molecular processes. It gives the theoretical background for the derivation of the theories from first principles. Enough details are provided to allow numerical implementation of the methods. The book gives the necessary background for understanding the approximations behind the methods and the working schemes for treating energy transfer processes from diatomic to polyatomic molecules, reactions at surfaces, non-adiabatic processes, and chemical reactions.
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Gaston, J. S. Hill. Reactive arthritis and enteropathic arthropathy. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199642489.003.0115.
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Reactive arthritis (ReA), and enteropathic arthritis secondary to inflammatory bowel disease, are forms of spondyloarthritis, all of which share an association with HLA B27 and can involve both axial and peripheral joints. Genetic studies strongly implicate the cytokines IL-17 and IL-23 in their pathogenesis, and evidence for autoimmunity is lacking. ReA is triggered by particular bacteria, mainly affecting the gut and genitourinary tract, though infections are sometimes asymptomatic. Classically an acute oligo- or monoarthritis with enthesitis occurs, often with inflammatory back pain, though mild polyarthritis can also occur. Septic and crystal-induced arthritis are the principal differential diagnoses. Extra-articular features may aid diagnosis, which otherwise requires laboratory evidence of preceding infection. Bacterial components traffic to the joint (which is nevertheless sterile), and elicit local proinflammatory immune responses. Most ReA is self-limiting, but persistent cases may require disease-modifying anti-rheumatic drugs or even biologics.
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Gaston, J. S. Hill. Reactive arthritis and enteropathic arthropathy. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199642489.003.0115_update_002.
Full textAbstract:
Reactive arthritis (ReA), and enteropathic arthritis secondary to inflammatory bowel disease, are forms of spondyloarthritis, all of which share an association with HLA B27 and can involve both axial and peripheral joints. Genetic studies strongly implicate the cytokines IL-17 and IL-23 in their pathogenesis, and evidence for autoimmunity is lacking. ReA is triggered by particular bacteria, mainly affecting the gut and genitourinary tract, though infections are sometimes asymptomatic. Classically an acute oligo- or monoarthritis with enthesitis occurs, often with inflammatory back pain, though mild polyarthritis can also occur. Septic and crystal-induced arthritis are the principal differential diagnoses. Extra-articular features may aid diagnosis, which otherwise requires laboratory evidence of preceding infection. Bacterial components traffic to the joint (which is nevertheless sterile), and elicit local pro-inflammatory immune responses. Most ReA is self-limiting, but persistent cases may require disease-modifying anti-rheumatic drugs or even biologics.
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Thomas, Emily. Early British Reactions to Absolutism: 1664 to 1687. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780198807933.003.0006.
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This chapter considers early British reactions to absolutism between the start of Barrow’s pertinent lectures in 1664, and the publication of Newton’s Principia in 1687. Although the amount of discussion absolutism received in Britain during this period was much less than it would receive later, it was already capturing the attention of some important thinkers. The reactions to absolutism were mixed. Different kinds of absolutism about space or time was adopted by thinkers such as Samuel Parker, Robert Boyle, and John Turner. In contrast, absolutism was rejected by philosophers such as Margaret Cavendish, Ralph Cudworth, Nathaniel Fairfax, and Anne Conway.
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Bhole, Malini. Hypersensitivity diseases. Edited by Patrick Davey and David Sprigings. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199568741.003.0300.
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Hypersensitivity reactions are aberrant immune responses that are provoked by innocuous extrinsic or self-antigens, are mediated by B-cells or T-cells, and may result in tissue or organ damage. Coombs and Gell classified hypersensitivity reactions into four types, based on the different immune responses: type I, or immediate hypersensitivity; type II, or antibody-mediated (humoral) cytotoxicity; type III, or immune-complex disease; and type IV, or delayed hypersensitivity. This chapter reviews the clinical features, diagnosis, and management of hypersensitivity reactions.
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Palmer, Thomas. Reception in England. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780198816652.003.0005.
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This chapter explores reactions to the Jansenist anti-casuist and anti-Jesuit writings among Restoration religious thinkers and pamphleteers. These ranged from a straightforward assimilation of the material into existing structures of anti-Catholic thinking, to a more nuanced reception, which took account of the positive theological case argued by the Port-Royalists as well as the colourful evidence of Catholic iniquity which their polemics comprised. The latter added little that was absolutely new for English thinkers already conversant with Catholic theology and casuistry, but their style and power was striking, and their impact is visible across English religious discourse in the period. The manner in which they were used, furthermore, points to divisions within English theology. Their focus on morality, and their technical criticisms of probabilism, it is suggested, were of greatest relevance to thinkers reacting against a theological framework which prioritized faith over obedience, and denigrated the authority of reason.
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Javanbakht, Arash, and Gina R. Poe. Behavioral Neuroscience of Circuits Involved in Arousal Regulation. Edited by Israel Liberzon and Kerry J. Ressler. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780190215422.003.0007.
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This chapter evaluates the evidence that hyper-reactive noradrenergic responses during trauma contribute to hyperarousal symptoms in PTSD, including disturbances in sleep. Some genetic vulnerability for PTSD involves the adrenergic system, and a hyperactive central noradrenergic system might serve to over-consolidate and sustain the affective component of fear memories. Reduced moderation of noradrenergic reactions during low hormone phases of the menstrual cycle could also lead to increased susceptibility to PTSD. This chapter considers a mechanism by which hyperactivity in the noradrenergic system during sleep would impair REM sleep theta and non-REM sleep spindles in the limbic system, both of which are implicated in the consolidation of new safety memories, thereby compromising extinction recall and setting into motion a positive feedback loop in PTSD pathophysiology, involving hyperarousal, failure to integrate contextual information, and biased attention to threat. If so, novel pharmacotherapeutic interventions inhibiting the noradrenergic system during sensitive periods in sleep should be considered.
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Helm, Bennett W. Communal Values and Character-Oriented Reactive Attitudes. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780198801863.003.0007.
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Whereas most accounts of the reactive attitudes and of responsibility focus on norms of action, we must also consider norms of character: norms that govern the kind of person we can or must be. We are bound by norms of character and so responsible to fellow members for who we are in the same way as for norms of action: via the interpersonal rational patterns in our reactive attitudes. Accordingly, this Chapter develops an account of pride, shame, esteem, and contempt as character-oriented reactive attitudes, clarifies the sense in which these are globalist emotions, distinguishes between personal and social forms of pride and shame, and provides a partial defense of the value of shame and contempt. The result both illuminates the distinction between guilt and shame and, more fundamentally, provides a unified account of responsibility without dividing it into aretaic and accountability faces as Gary Watson does.