Relevant bibliographies by topics / Ocel 11 320.3

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Academic literature on the topic 'Ocel 11 320.3'

Author: Grafiati
Published: 28 June 2021
Last updated: 12 February 2022

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Journal articles on the topic "Ocel 11 320.3"

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RocíoOviedoZampaña, M., Jesús Flores González, Antonio J. Guerrero Altamirano, Jesus Martínez Faure, and Juan A. Péculo Carrasco. "AP036 Comparision between in-and out-of-hospital cardiac arrest: 320 CPR analyzed." Resuscitation 82 (October 2011): S18. http://dx.doi.org/10.1016/s0300-9572(11)70070-3.

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Francis, Lanie, Judy Anderson, Michael Timm, Noriyoshi Kurihara, Ujjal Singha, Yazan Alsayed, Alissa Huston, Suzanne Lentzsch, G. David Roodman, and Irene M. Ghobrial. "The Effect of Rapamycin, 17-AAG and the Combination on the Bone Marrow Microenvironment in Multiple Myeloma (MM)." Blood 106, no. 11 (November 16, 2005): 3476. http://dx.doi.org/10.1182/blood.v106.11.3476.3476.

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Abstract The bone marrow microenvironment in MM is characterized by the presence of upregulated osteoclast activity (OCL) and increased angiogenesis. We have recently demonstrated that the HSP90 inhibitor 17-AAG (provided by the NCI) and the mTOR inhibitor rapamycin (LC Laboratories, MA) have synergistic inhibitory activity on MM cells. The objective of this study was to determine the effect of rapamycin, 17-AAG and the combination on OCL formation and angiogenesis. Rapamycin (0.01–100nM), 17-AAG (10–1000nM) and the combination was tested using an in vitro human OCL formation assay and a human angiogenesis assay (AngioKit, TCS Cellworks, UK). Nonadherent human marrow mononuclear cells (1 x 105/100 μL) were plated in 96-well plates in the presence or absence of DMSO, rapamycin, 17-AAG or the combination. RANKL (100ng/ml) and MCSF (20ng/ml) were added to all wells except control media and MCSF. After 3 weeks, cells were fixed, and the number of OCL-like multinucleated cells were scored. To test the effect of the agents on early OCL precursors, we added the inhibitory agents on days 1, 7 or 14 of the culture. The AngioKit is comprised of human endothelial cells in a 24 well plate. The endothelial cells proliferate and then migrate through the matrix to form tubular structures and anastomosing tubules by 2 weeks. Two control wells were treated with VEGF (+ve control) and two with suramin (−ve control). The optimized medium and test samples were replaced on days 4, 7, and 9 after initial treatment. On day 11, cultures were fixed and stained with antibodies to CD31 to detect vessel formation. The degree of tubule formation was quantitated using computerized image analysis (Angiosys, TCS Cellworks, UK). Single agent rapamycin (20–100nM) inhibited OCL formation by 35% as compared to control in all tested doses indicating that PI3K/mTOR is an important regulator of OCL formation. The effect was similar on day 7 and day 14 indicating that this pathway is important for early and late OCL formation. 17-AAG 100–600nM significantly inhibited OCL formation with 100nM 17-AAG inducing 12% OCL formation as compared to control, while 300 and 600nM completely abrogated OCLs (0% OCLs). This effect was similar at day 7. However, when 17-AAG was added on day 14, it only induced 50–60% reduction in OCL formation indicating that 17-AAG affects early OCL formation. The combination of the two agents completely inhibited OCL formation on day 1 and 7 and led to a 65% reduction in OCLs when added on day 14 of the culture. Rapamycin showed a marked decrease in angiogenesis (similar to the negative control suramin), even at the lowest level tested of 0.01nM. 17-AAG demonstrated some inhibition of angiogenesis at 10 nM, and completely abrogated angiogenesis at 500–1000nM. In summary, rapamycin and 17-AAG inhibit OCL formation and angiogenesis. The effect of 17-AAG was on early OCL formation while rapamycin was on both early and late OCL. These results are contradictory to previous data indicating that 17-AAG increases OCL activity in MM. Rapamycin had a significant inhibitory effect on angiogenesis even at low doses. These results demonstrate that the use of rapamycin analogues and 17-AAG in clinical trials may have a therapeutic effect, not only on MM cells, but also on the bone marrow microenvironment. Supported in part by an ASH Scholar Award and an MMRF grant.
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Lalani, Nafisha, Sue Richter, Peter W. M. Chung, Neil Eric Fleshner, Michael A. Jewett, Alexandre Zlotta, Robert Glen Bristow, Michael Milosevic, and Srikala S. Sridhar. "Concurrent cisplatin and radiotherapy: Decision making, tolerability, and outcomes for patients treated in a multidisciplinary bladder clinic." Journal of Clinical Oncology 32, no. 4_suppl (February 1, 2014): 320. http://dx.doi.org/10.1200/jco.2014.32.4_suppl.320.

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320 Background: For select muscle invasive bladder cancer (MIBC) patients, a multimodal approach using transurethral resection of the bladder tumor (TURBT) followed by concurrent cisplatin and external beam radiotherapy (EBRT) provides a curative bladder-sparing alternative to cystectomy. Our aim was to review decision making, tolerability and outcomes for patients treated in a multidisciplinary bladder clinic. Methods: Between June 1998-June 2011, MIBC patients treated with TURBT and concurrent cisplatin (40mg/m2 weekly) with EBRT (60-66Gy in 30-33 fractions to the bladder and pelvis) were identified. Post-treatment cystoscopy was performed every 3 months with regular imaging. Results: A total of 64 patients were assessed; mean age 73 (43-89), 83% were male. The decision to attempt bladder-sparing was based on patient preference (58%), nonsurgical candidate (25%), or unknown (17%). Patients received a mean 5/6 weeks of cisplatin with the most common toxicity being a 14% overall risk of grade 0-1 renal toxicity by NCIC CTC criteria. All patients completed the prescribed EBRT. No patients experienced acute toxicity requiring cystectomy or causing death. At a median follow-up of 3.5 years, 50/64 (78%) patients were alive and had their own bladders, 7/64 (11%) were alive after cystectomy for recurrence, 7/64 (11%) died. Of the 24/64 (38%) recurrences: 3/64 (5%) had positive cytology/carcinoma in-situ and received intravesicle therapy; 1/64 (2%) had local superficial recurrence and underwent TURBT; 7/64 (11%) had local invasive recurrence requiring cystectomy; 13/64 (20%) had distant recurrence, 6 received chemotherapy and 7 were observed. Estimated disease free survival was 51%, and overall survival was 90% at 3.5 years. Conclusions: Bladder-sparing therapy with concurrent cisplatin and EBRT is a well-tolerated and effective approach with outcomes comparable to cystectomy in carefully selected patients. Prospective trials are required to delineate clinical and molecular factors to further triage patients into sub-groups who may benefit from bladder sparing with neoadjuvant/adjuvant chemotherapy or molecularly-targeted agents to improve survival.
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Kuhn, J. G., H. A. Burris, S. F. Jones, D. W. Hein, N. T. Willcutt, F. A. Greco, D. S. Thompson, A. A. Meluch, R. S. Schwartz, and D. M. Brown. "Phase I/II dose-escalation trial of amonafide for treatment of advanced solid tumors: Genotyping to optimize dose based on polymorphic metabolism." Journal of Clinical Oncology 25, no. 18_suppl (June 20, 2007): 2503. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.2503.

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2503 Background: Amonafide (AMF), a synthetic imide derivative of naphthalic acid, is a topoisomerase II inhibitor and is subject to polymorphic metabolism based on acetylation genotype. AMF is extensively metabolized by N-acetyltransferase 2 (NAT2) to N- acetylamonafide (AAMF) which has activity nearly equipotent to AMF. In our phase I evaluation, we observed a correlation between NAT2 genotype, AMF/AAMF pharmacokinetics and toxicity (J Clin Oncol 22 [14S]: 2023, 2004). Patients (pts) with slow (S) acetylator genotype tolerated higher doses than those with rapid/intermediate (R/I) acetylator genotype. The present Phase II portion was designed to prospectively determine the dose of AMF based on NAT2 genotype and focused on selected tumor types. Methods: NAT2 genotyping of genomic DNA from blood samples was done prospectively to determine acetylator status of each pt. AMF was administered IV weekly x 3 q4wk, escalation range 320 to 400 mg/m2 for R/I and 400 to 500 mg/m2 for S acetylators. Primary endpoints: safety, MTD, tumor measurements or sustained decreases in tumor markers. Results: Total 47 pts (21 M/26 F), median 66 yr, PS 0–2, acetylator status R/I (26), S (21) with ovarian (11) or prostate (9), breast (8), colon (4) cancers (CA) and other common tumors refractory to therapy were treated; 30 of 47 pts were dosed based on prospective genotyping. Of these 30 pts, 17 were R/I acetylators: no toxicity at 320 mg/m2 AMF in 7/11 pts and manageable myelosuppresion in 4/11 pts observed days 15–21 of cycle but not dose-limiting (DLT); DLT in 3/6 pts at 400 mg/m2. In the 13 S acetylators: at 400 mg/m2 no DLT in 8 pts; DLT in 2/5 pts treated at 500 mg/m2. Other side effects included nausea/vomiting, fatigue and anemia. Of all 47 pts, biologic activity was seen in 6 pts: 3/9 prostate CA (decreased PSA), 2/11 ovarian CA (decreased CA125) and 1/1 GIST (decreased lymph nodes). Conclusions: MTD determined to be 320 mg/m2 in R/I and 400mg/m2 weekly x 3q 4 weeks in S acetylators, respectively, supporting hypothesis that AMF dosing based on prospective NAT2 genotyping may allow for dose optimization based on drug metabolism and result in better tolerance. Phase II assessments at the MTD dose levels are currently ongoing for prostate cancer. No significant financial relationships to disclose.
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Wei-Tian, Wang, Yang Guang, Chen Zheng-Hao, Zhou Yue-Liang, Lü Hui-Bin, and Yang Guo-Zhen. "Large third-order optical nonlinearity in Au nanometre particle doped BaTiO 3 composite films near the resonant frequency." Chinese Physics 11, no. 12 (December 2002): 1324–27. http://dx.doi.org/10.1088/1009-1963/11/12/320.

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Gómez-Amo, J. L., V. Estellés, A. di Sarra, R. Pedrós, M. P. Utrillas, J. A. Martínez- Lozano, C. González-Frias, E. Kyrö, and J. M. Vilaplana. "Operational considerations to improve total ozone measurements with a Microtops II ozone monitor." Atmospheric Measurement Techniques Discussions 4, no. 6 (December 16, 2011): 7529–58. http://dx.doi.org/10.5194/amtd-4-7529-2011.

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Abstract. A Microtops II "ozone monitor" with UV channels centered at 305.5, 312.5, and 320 nm has been used routinely in six experimental campaigns carried out in several geographic locations and seasons, covering latitudes from 35 to 68° N during the last ten years (2001–2011). The total ozone content is retrieved by Microtops II by using different combinations (Channel I, 305.5/312.5 nm; Channel II, 312.5/320 nm; and Channel III, 305.5/312.5/320 nm) of the signals at the three ultraviolet wavelengths. When a calibration was used and the airmass limit was fixed to 3, Microtops II produce mean relative deviations with respect to the Brewer of 0.1, −11, and 8% respectively for the Channel I, Channel II, and Channel III retrieval. The performance of the Microtops retrieval has been stable during the last ten years. Channel I represents the best option to determine the instantaneous total ozone content. Channel II and III values appear weakly sensitive to temperature, ozone content, and aerosols. Channel II is more stable than Channel I for airmasses larger than 2.6. The conclusions do not show any dependence on latitude and season.
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Zeller, Thomas, Ulrich Frank, Christian Müller, Karlheinz Bürgelin, Uwe Schwarzwälder, Lutz Sinn, Barbara Horn, Helmut Roskamm, and Franz-Josef Neumann. "Technological Advances in the Design of Catheters and Devices Used in Renal Artery Interventions: Impact on Complications." Journal of Endovascular Therapy 10, no. 5 (October 2003): 1006–14. http://dx.doi.org/10.1177/152660280301000526.

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Purpose: To analyze the impact of technical improvements in stent devices and guiding catheters (e.g., reduced device diameter, increased flexibility) on the complication rates associated with percutaneous renal artery interventions. Methods: During a 5-year period (1997–2001), 268 consecutive patients (178 men; mean age 67±9 years) had 370 atherosclerotic renal artery stenoses (RAS) ≥70% treated with angioplasty/stenting in 320 procedures. The guiding catheter technique was used routinely until 2000; in 2001, a guiding sheath was used in 29% of cases. From 1997 to 2000, sealing devices were frequently used for sheath removal; during the last year, the sheaths were removed using the Femostop device. Results: In 320 interventions, 32 (10%) complications occurred, with a decreasing frequency during the last 2 years (1996/97: 13% [7/53]; 1998: 16% [9/57]; 1999: 15% [11/74]; 2000: 4% [3/70]; 2001: 3% [2/66]). There were 21 (6.6%) local complications, including 4 cases requiring permanent hemodialysis after the intervention and 11 (3.4%) access site complications. No procedure-related death occurred. During the study period, the average sheath diameter was reduced from 8.15±0.76 F to 6.15±0.63 F (p<0.05). Mean procedural time was reduced from 42±13 minutes to 23±11 minutes (p<0.05). The initial heparin dose was reduced from 10,000 to 5000 units. Conclusions: In parallel with the use of more flexible catheters and premounted stents of lower profile, the complication rate of renal angioplasty/stenting of atherosclerotic RAS has been reduced significantly during a 5-year period.
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Yi, Lu, Li Qing-An, Di Nai-Li, Li Run-Wei, Ma Xiao, Kou Zhi-Qi, and Cheng Zhao-Hua. "Evidence of phase separation in Nd 1- x Sr x MnO 3 ( x =0.50, 0.51, 0.52, 0.53, 0.54, 0.55)." Chinese Physics 12, no. 11 (October 30, 2003): 1301–4. http://dx.doi.org/10.1088/1009-1963/12/11/320.

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Udupa, Ganesha, M. Singaperumal, R. S. Sirohi, and M. P. Kothiyal. "Characterization of surface topography by confocal microscopy: I. Principles and the measurement system." Measurement Science and Technology 11, no. 3 (February 14, 2000): 305–14. http://dx.doi.org/10.1088/0957-0233/11/3/320.

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Adjel-Lalouani, Farah, Sara Hammouchi, Nora Trad, and Souad Mehalaine. "Interactive effects of salt stress and gibberellic acid (GA3) on germination and ion content of barley (Hordeum vulgare L.)." South Asian Journal of Experimental Biology 11, no. 3 (May 24, 2021): 311–20. http://dx.doi.org/10.38150/sajeb.11(3).p311-320.

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Salinity is becoming one of the most important environmental factors lim-iting crop productivity around the world. Different strategies are employed to achieve optimal growth in saline conditions by employing some biochemi-cal agents such as plant hormones. This article provides an experimental investigation that was conducted to explore the effect of salt stress and hor-mones on barley. Three levels of salt stress tests, (0, 100 and 200 mM NaCl) on four barley genotypes (Hordeum vulgare L.): Jaidor, Fouara, Saida, and Tichedrett, were studied. Each test was treated with and without 20 μg/l of Gibberellic acid (GA3). Plants were assessed at germination and seedling growth stages to determine the percentage and the speed of germination, the coleoptile length, and the root length. In addition, the experimental in-vestigation was conducted to explore amount and the ash content of potas-sium and sodium due to salinity and the effect of gibberellic acid application to mitigate the impact of salt stress. The results revealed that the use of gib-berellic acid was beneficial in reducing the depressive effect of salt. In gen-eral, Jaidor registered the best results and Fouara registered the lowest ones. However, Saida and Tichedrett were marked with a high root K/Na ratio. In conclusion, the application of salt stress negatively affected the growth of the four studied genotypes. This effect is even more important as the intensity of the stress is high. However, the application of the GA3 hor-mone reduced the negative impact of the salt stress on all measured param-eters.
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Dissertations / Theses on the topic "Ocel 11 320.3"

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Vahala, Jiří. "Výroba krytu kloubu přívěsného vozíku." Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2021. http://www.nusl.cz/ntk/nusl-445155.

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The project elaborated design of technology production of the trailer connecting joint from the deep drawing sheet iron 11 320. Pursuant to of the literary pursuit a problem of the deep drawing and calculation was designed progressive tool concatenate four operations. The lower ejectors are using for ejecting components. The drawing instrument especially made of non-standardised components and it is designed for use on a hydraulic press CTH 250, with nominal tensile force 250 kN. Drawing punch and drawing die are produced from alloyed instrumental steel 19 436 heat-worked according to drawing documentation. The technical and economical evaluation was focused on the forming cost, which is 2 922 893 CZK in total.
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Kos, Bohumír. "Výroba držáku klaksonu." Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2010. http://www.nusl.cz/ntk/nusl-228938.

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The project elaborated in frame of engineering studies branch 2303T002. The project is submitting design of technology production of the part from the deep drawing sheet iron 11 320.30. Pursuant to of the literary pursuit a problem of the shearing, bending and calculation was designed manufacturing in transfer combined die, which is set on the eccentric press LEXN 100 C (producer TOMA INDUSTRIES s.r.o. Trnava), with nominal force 1000 kN. Functional parts of tool are produced of tool steel 19 436.3.
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Dušek, Otakar. "Výroba uzavřené matice objemovým tvářením." Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2014. http://www.nusl.cz/ntk/nusl-231211.

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The diploma thesis suggests a producing plan of the cover nut using cold forming technology. The component will be made of the structural steel 11 320 5R. Size of its assumed annual production is 800 000 pieces. The best option was chosen from four suggested production versions. A wire with a diameter of 13.2 mm was designed as a semi-product. The component will be made in four forming operations. Roll forming machine TPM 8 (produced by Šmeral Brno) with a nominal force of 1000 kN was elected for the proposed manufacturing technology. Drawing documentation was elaborated, which includes drawing of the rolling tool assembly and drawing of tools for 3rd operation (backward extrusion). The results of the economic evaluation shows that the production cost of one nut is 1 CZK.
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Kosek, Lukáš. "Výroba pouzdra pružiny objemovým tvářením." Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2013. http://www.nusl.cz/ntk/nusl-230629.

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The master’s thesis presents a concept for spring bush manufacturing made of 11 320-5R steel by cold forming. Five steps process of manufacturing is based on the literary studies and technical calculations. The multistage cold forming machine HATEBUR AKP 5-5 was chosen for selected option of forming technology. As raw material was used cylinder shape with diameter of 26 mm and length of 29 mm. The economic results fix the price of one component of 16 CZK for annual dose 250 000 pieces.
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Koukal, Vojtěch. "Výroba spojovacího čepu objemovým tvářením." Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2014. http://www.nusl.cz/ntk/nusl-231212.

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The project of master’s thesis elaborated within engineering studies of engineering technology deals with concept of manufacturing procedure of connecting pin made of steel 11 320 5R with cold forming. Two variants of production technique were projected based on the literature study of the cold heading and cold extrusion. Selected variant, for which the technological calculation was accomplished, consists of five forming operations. Manufacture was projected for multistage automatic forming machine TPM 8-A made by manufacturer Šmeral Brno with nominal forming force 1000 kN. Tool steel 19 436 was chosen as a material of extrusion and heading tools.
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Books on the topic "Ocel 11 320.3"

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S&S Studio. Medium Sudoku Puzzle Book for Adults Volume 3: 320 Medium Puzzles Volume 3, Medium Sudoku Book for Adults to Sharpen Their Brains, 8. 5 X 11 In. Independently Published, 2020.

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Book chapters on the topic "Ocel 11 320.3"

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"maize, 1.4-2.7%; of waxy barley, 2.1-8.3%; and of waxy swell only slightly in cold water. Granules differ in size rice 0-2.3%; thus the range of amylose contents of the and shape among plants. For example, corn starch has an waxy wheats is comparable to that of other waxy cereal average diameter of about 15 1.1,M, wheat starch has a bi-grains. Biochemical features of starch from waxy wheats modal size distribution of 25-40 and 5-10 [tm, potato are similar to those of waxy maize [71]. starch has an average size of 40 WTI, and rice starch has an Starch from barley contains 22-26% amylose, the rest average size of 5µm [99]. being amylopectin [28]. However, samples of 11-26% The particle sizes of starch granules have recently re-amylose are known, and starch from waxy barley contains ceived much attention because of their important roles in only 0-3% amylose, while high-amylose starches contain determining both the taste and mouthfeel of fat substitutes up to 45%. and the tensible properties of degradable plastic films. Amylose content of rice is categorized as very low Daniel and Whistler [39] reported that small-granule (0-9%), low (9-20%), intermediate (20-25%), or high starch about 2 !um in diameter, or similar in size to the lipid (25-33%) [124]. The amylose content of long grain rice micelle, had advantages as a fat substitute. Lim et al. [117] ranges from 23 to 26%, while medium grain ranges from investigated the use of starches of different particle size in 15 to 20% and short grain ranges from 18 to 20% [103]. degradable plastic film. They reported that a linear correla-Oat amylose content (16-27%) is similar to that of tion between film thickness and particle size and an in-wheat starch, but oat amylose is more linear and oat amy-verse linear correlation between film thickness and particle lopectin is more branched than that found in wheat [121]. size. Small-granule starches may also be used as face pow-Most sorghum starch is similar in composition to corn der or dusting powder, as a stabilizer in baking powder, and contains 70-80% branched amylopectin and 21-28% and as laundry-stiffening agents. amylose [127]. However, waxy or glutinous sorghum con-The size of the wheat starch granule is 1-30 lam, the tains starch with 100% amylopectin and has unique prop-size distribution being bimodal. Such a bimodal size distri-erties similar to waxy corn [158]. Badi et al. [11] reported bution is characteristic of wheat starch, as well as of rye 17% amylose in starch from one pearl milled population. and barley starches. Wheat starch consists of two basic Gracza [69] reviewed the minor constituents of starch. forms: small spherical granules (about 5-10 wri) and larg-Cereal starches contain low levels of lipids. Usually, the er lenticular granules (about 25-4011m). The small B-gran-lipids associated with starch are polar lipids. Generally, the ules are spherical and have a diameter of less than 10 wrt; level of lipids in cereal starch is between 0.5 and 1%. Be-a mean value of about 4 lam has been reported. The large sides low levels of other minerals, starches contain phos-A-granules are lenticular and have a diameter greater than phorus and nitrogen. In the cereals, phosphorus occurs 10 lam, with a mean 14.11.1m. In reality, the granules have a mostly in the form of phospholipids. The nitrogen is gener-continuous distribution of granule size within the range ally considered to be present as protein, but it may also be designated for that starch. Amylose and amylopectin are a constituent of the lipid fraction. intermixed and distributed evenly throughout the granule. The interaction between amylose and lipids is more Many believe that the composition and properties of small powerful by far than that between amylopectin and lipids and large granules are similar, but this is a subject of some [55]. It is well established that polar lipids (e.g., mono-argument and the subject of many research studies [42]. glycerides, fatty acids, and similar compounds) form a hel-Kulp [110] evaluated the fundamental and bread-mak-ical inclusion complex with the amylose molecule, be-ing properties of small wheat starch granules and com-tween the hydrocarbon chain of the lipid and the interior of pared them with those of regular starch. Small granules the amylose helix. were found to be lower in iodine affinity, indicating differ-ences in amylose levels or some fundamental structural differences. Gelatinization temperature ranges, water-binding capacities, and enzymic susceptibilities of small Starch is laid down in the shape of particles in special amy-granules were higher than those of regular ones. loplast cells in the plant. These particles are called gran-Rice has one of the smallest starch granules of cereal ules, and they are the means by which the plant stores en-grains, ranging in size from 3 to 5 pm in the mature grain, ergy for the carbohydrate in a space-saving way, but also to although the small granules of wheat starch are almost the make the energy easily accessible when the seed germi-same size [33]. The small granule size of that starch results nates [57]. One starch granule is synthesized in each amy-in physical properties that make it useful as a dusting flour loplast, and the shape and size of a starch granule is typical in bakeries. Rice starch amyloses have degree of polymer-of its botanical origin. ization (DP) values of 1000-1100 and average chain Starch granules are relatively dense, insoluble, and lengths of 250-320. These structural properties of amylose." In Handbook of Cereal Science and Technology, Revised and Expanded, 405–32. CRC Press, 2000. http://dx.doi.org/10.1201/9781420027228-41.

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Conference papers on the topic "Ocel 11 320.3"

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Becht, Charles, Tony Paulin, Don Edwards, Mark Stonehouse, William Santiago Lock, and Charles Becht. "Sustained Stress Indices (SSI) in the B31.3 2010 Edition." In ASME 2014 Pressure Vessels and Piping Conference. American Society of Mechanical Engineers, 2014. http://dx.doi.org/10.1115/pvp2014-28267.

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The 2010 version of B31.3 introduced sustained stress indices (SSI’s) in paragraph 320. Using methods in references [1],[2],[3],[4],[5], and [11], a test procedure was developed to evaluate these SSI’s for standard metallic piping components. The test procedure has been incorporated into draft versions of B31J so that the sustained stress index can be produced at the same time stress intensification or flexibility factor tests are performed for a particular component. This paper describes the sustained stress index and the B31J test procedure used to determine the SSI.
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Day, H. J., R. Cherrey, D. O'Hara, and J. Carabello. "INCIDENCE OF PROCAINAMIDE-INDUCED LUPUS ANTICOAGULANT." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644241.

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Isolated cases of lupus anticoagulants (LA) in association with procainamide have been reported. This study was done to estimate the frequency of LA in patients taking procainamide. Two groups of patients were evaluated: Group A: 110 hospitalized patients (84 males, 26 females, ages 51-78, mean age 74.3) and Group B: 80 ambulatory patients (54 males, 26 females, ages 36-89, mean 67.5 years). The latter group of patients was on this drug for a period of two-five years, while the former group hadbeen on drug at least two full days. All patients were screened with baseline laboratory data including activated partial thromboplastin time (APTT) and prothrombin time (PT) which were performed using Auto APTT® and Simplastin® on a Coagulamate X2® (General Diagnostics/Organon Teknika). Patients taking drugs known to alter the APTT and PT were excluded. All patients were followed with daily (hospital patients) or weekly (ambulatory patients) APTT and PT. Prolongation of the APTT of 5 sec or PT of 3 sec over baseline was considered as a positive LA screening test. Patients with a positive screening test were further evaluated with tissue thromboplastin inhibitor assay (TTI), platelet neutralization procedure (PNP, anti-nuclear antibodies (ANA) and blood serology (RPR). In Group A. 11 out of 110 (1096) developed prolonged APTT while on procainamide . Of these, 9 developed abnormal TTI and 2 had positive PNP. The ANA was positive (titers of 1:320-1:2560) in 10 patients with the only positive RPR test, being in the patient with the highest ANA titer. In Group B, 12 out of 80 (1596) developed prolonged APTT, 11 had positive TTI. The ANA titer was elevated in all positive cases, although one patient's titer was 1:30. The PNP was positive in 1/12. All blood serologies were negative in this group. The difference in incidence between Groups A and B may reflect longer exposure to drug in the latter group. This difference is not statistically significant. This study indicates that the incidence of procainamide-induced lupus antocoagulant is between 10-1596 when the APTT (or PT) is used as a screening test. The TTI and ANA seem to have equal sensitivity in this syndrome when taking this drug. The failure of the PNP to be sensitive to LA may be due to the minimal prolongation of the APTT arbitrarily chosen as representing a positive screening test.
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