Academic literature on the topic 'Obstructive'

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Journal articles on the topic "Obstructive"

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Bashir, Ahsan, Sabina Qureshi Ahmad, Joshua Silverman, Emily Concepcion, and Haesoon Lee. "Post-obstructive pulmonary edema from aspirated nuts." SAGE Open Medical Case Reports 5 (January 1, 2017): 2050313X1771739. http://dx.doi.org/10.1177/2050313x17717391.

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Objectives: Post-obstructive pulmonary edema is thought to occur from hemodynamic changes secondary to forced inspiration against the closed airway due to acute or chronic airway obstruction. We report a case of a 13 month-old boy who developed pulmonary edema from aspirated foreign body, nuts. Methods: He underwent emergency bronchoscopy to confirm the clinical diagnosis of aspirated nuts in the trachea and nuts were removed endoscopically. His trachea was then intubated and he was mechanically ventilated with oxygen. Results: He developed florid pulmonary edema early in the course with tracheal obstruction and during endoscopic removal of nuts. After removal of obstruction he was ventilated mechanically and pulmonary edema cleared rapidly. Conclusions: Aspirated nuts obstructing trachea can induce obstructive pulmonary edema. Early recognition of foreign body obstruction based on clinical history and its removal resolved pulmonary edema.
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Phua, C. Q., W. X. Yeo, C. Su, and P. K. H. Mok. "Multi-level obstruction in obstructive sleep apnoea: prevalence, severity and predictive factors." Journal of Laryngology & Otology 131, no. 11 (September 5, 2017): 982–86. http://dx.doi.org/10.1017/s0022215117001906.

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AbstractObjectives:To characterise multi-level obstruction in terms of prevalence, obstructive sleep apnoea severity and predictive factors, and to collect epidemiological data on upper airway morphology in obstructive sleep apnoea patients.Methods:Retrospective review of 250 obstructive sleep apnoea patients.Results:On clinical examination, 171 patients (68.4 per cent) had multi-level obstruction, 49 (19.6 per cent) had single-level obstruction and 30 (12 per cent) showed no obstruction. Within each category of obstructive sleep apnoea severity, multi-level obstruction was more prevalent. Multi-level obstruction was associated with severe obstructive sleep apnoea (more than 30 events per hour) (p = 0.001). Obstructive sleep apnoea severity increased with the number of obstruction sites (correlation coefficient = 0.303, p < 0.001). Multi-level obstruction was more likely in younger (p = 0.042), male (p = 0.045) patients, with high body mass index (more than 30 kg/m2) (p < 0.001). Palatal (p = 0.004), tongue (p = 0.026) and lateral pharyngeal wall obstructions (p = 0.006) were associated with severe obstructive sleep apnoea.Conclusion:Multi-level obstruction is more prevalent in obstructive sleep apnoea and is associated with increased severity. Obstruction at certain anatomical levels contributes more towards obstructive sleep apnoea severity.
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Lau, W. Y., C. K. Leow, K. L. Leung, Thomas W. T. Leung, Michael Chan, and Simon C. H. Yu. "Cholangiographic Features in the Diagnosis and Management of Obstructive Icteric Type Hepatocellular Carcinoma." HPB Surgery 11, no. 5 (January 1, 2000): 299–306. http://dx.doi.org/10.1155/2000/79241.

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In 11 years and 3 months, 2037 patients with HCC were seen and 48 patients (2.4%) were diagnosed to have obstructive icteric type HCC. Five patients were terminally ill and were not investigated further. Forty three patients were initially investigated by endoscopic retrograde cholangiography (ERC) or percutaneous transhepatic cholangiogram (PTC) and classified as having obstructive icteric type 1, 2, or 3 HCC based on the cholangiographic findings. The obstruction in type 1 HCC was due to intraluminal tumour casts and/or tumour fragments obstructing the hepatic ductal confluence or common bile duct, while intraluminal blood clots, from haemobilia, filling the biliary tree was the cause in type 2 HCC. The pathology in type 3 HCC was extraluminal obstruction by extensive tumour encasement of the intra–hepatic biliary ductal system and/or extrinsic compression of the hepatic and common bile ducts by tumour(s) and/or malignant lymph nodes. At the initial ERC/PTC, 10 patients (5 resected, 50%) had obstructive icteric type 1 and 23 patients (0 resected) had obstructive icteric type 3 HCC. Of the 10 patients initially classified according to cholangiography to have obstructive icteric type 2 HCC, subsequent investigations revealed that 6 patients had type 1 HCC (4 resectable, 67%) and 4 patients had type 3 HCC (0 resectable). The classification of the obstructive icteric type HCC into types 1, 2, and 3, based on the initial cholangiographic appearances has simplified and rationalized our management strategy for this condition.
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Canonne-Guibert, Morgane. "Affections respiratoires supérieures." Le Nouveau Praticien Vétérinaire canine & féline 19, no. 81 (June 2022): 17–26. http://dx.doi.org/10.1051/npvcafe/2022054.

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Parmi les affections des voies respiratoires supérieures, selon le site anatomique touché, l’exploration diagnostique nécessitera souvent a minima un examen endoscopique, celui-ci pouvant suffire dans de nombreux cas. À ce titre, pour les atteintes laryngées et trachéales ou dans l’exploration d’un syndrome obstructif respiratoire des races brachycéphales, il convient de réaliser l’endoscopie chez un animal non intubé pour parfaitement visualiser les voies respiratoires dans leur position et leur mouvement naturels. Pour les atteintes nasales et nasopharyngées, l’examen tomodensitométrique pourra s’avérer complémentaire ; pour les atteintes trachéales, la radiographie reste un très bon examen dans le cadre des affections obstructives (collapsus, sténose, tumeur) compte tenu du contraste apporté par l’air luminal. De nombreuses affections conduiront à la programmation d’une intervention chirurgicale (syndrome obstructif respiratoire des races brachycéphales, paralysie laryngée, polype nasopharyngé, rétroversion épiglottique), d’autres motiveront une prise en charge mini-invasive (sténose nasopharyngée) ou une prise en charge plus spécifique comme lors de processus tumoral. Au détour de la démarche diagnostique de confirmation, il convient également de rechercher les éventuelles complications d’une atteinte obstructive : bronchopneumonie par aspiration, hyperthermie, anomalies œsophagiennes (dilatation aérique majeure, redondance, hernie hiatale, œsophagite). Dans le contexte d’urgence, la stabilisation d’une atteinte obstructive est peu spécifique et repose sur trois piliers : une oxygénothérapie, une sédation comprenant le plus souvent du butorphanol +/- alpha-2 mimétique et le traitement des complications éventuelles (antibiotique lors d’aspiration, antiacides et pansements lors de conséquences œsophagiennes). Enfin, toute obstruction respiratoire s’accompagne d’une inflammation et d’un œdème des muqueuses respiratoires et doit conduire à l’initiation d’une corticothérapie efficace et temporaire.
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AFZAL KIANI, ASMA, RANA HASSAN JAVAID, ABDUL GHAFFAR, and Shamrez Khan. "ULTRASONOGRAPHY IN OBSTRUCTIVE JAUNDICE." Professional Medical Journal 19, no. 04 (August 7, 2012): 436–41. http://dx.doi.org/10.29309/tpmj/2012.19.04.2245.

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Objective: To evaluate the validity of ultrasonography in patients who have obstructive jaundice. Design: Descriptive study.Place and duration of study: The study was carried out from September 2006 to May 2008 in department of Radiology Combined MilitaryHospital Quetta. Patients and Methods: A total of 30 patients; 14 male and 16 female underwent operation for obstructive jaundice. All of themhad preoperative ultrasonography. The site and nature of biliary obstruction were noted and the accuracy was determined with per-operativefindings / histological diagnosis as gold standard. Results: The cause of obstructive jaundice identified by ultrasonography with reasonablesensitivity of 90% and specificity of 90% for choledocholithiasis and sensitivity of 55.5% and specificity of 95.2% for pancreatic head tumours.Conclusions: Ultrasonography should be the first and best initial imaging procedure in patients who have obstructive jaundice and showsreasonable sensitivity and specificity to identify causes of obstruction in obstructive jaundice.
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Mohson, Khaleel I., and Zaid Hadi Kadhum. "Role of Interventional Radiology in the Management of Obstructive Jaundice: Achieving Drainage and Stenting." Open Access Macedonian Journal of Medical Sciences 10, B (March 9, 2022): 529–31. http://dx.doi.org/10.3889/oamjms.2022.8438.

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BACKGROUND: Obstructive jaundice due to the central malignant cause is really challenging for gastroenterologists and usually results in failed drainage of obstructing system, the percutaneous transhepatic biliary drainage (PTBD) usually results in a dramatic pathway opening. AIM: The study aimed to evaluate the role of interventional radiology (IR) in achieving drainage of obstructing system and subsequent reduction of serum bilirubin and its role in stenting the obstructing lesion. METHODS: A prospective study included 40 patients who complained of obstructive jaundice referred to IR unit in specialties surgical hospital from gastroenterology hospital after failed endoscopic drainage and stenting during the period from September 2020 to November 2021. RESULTS: Of 40 patients in study population, 26 are male and 14 females, their median age was 65 years, cholangiocarcinoma is leading cause of biliary obstruction, the technical success of PTBD was 100% and clinical success achieved by lowering of total serum bilirubin by 60% within 2 weeks seen in 75% of the patients, no significant major complications seen after procedure, and only 5% of the patients developed leaking bile along the drain tract. CONCLUSIONS: PTBD and transhepatic biliary stenting are amazing technique in acute and chronic management of patients with obstructive jaundice, achieve dramatic lowering of serum bilirubin, fighting biliary sepsis and long-term palliation of advanced biliary, pancreatic, and ampullary malignancy.
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Gaparkhoeva, Z. M., O. A. Bashkina, and E. N. Seliverstova. "Comparative characteristics of bronchial obstruction formation trigger mechanisms in children with bronchial asthma and recurrent obstructive bronchitis." Kazan medical journal 97, no. 1 (February 15, 2016): 66–69. http://dx.doi.org/10.17750/kmj2016-66.

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Aim. To study the comparative characteristics of the causative significant factors involved in the bronchial obstruction development in children with bronchial asthma and recurrent obstructive bronchitis.Methods. A cross-sectional (transversal) study of 50 children with bronchial asthma, 38 children with recurrent obstructive bronchitis was conducted. The differences and similarities of etiopathogenetic factors of the bronchial obstruction occurrence were revealed. According to medical history, in all patients regardless of the severity and duration of the disease at the time of examination, the impact of the factors, acting as triggers of bronchial asthma, according to patients, such as infectious agents, infectious allergens and aeroallergens, nighttime, climatic conditions deterioration, physical and/or emotional stress, was registered.Results. The main triggers that influence the bronchial obstruction occurrence in children with asthma were infectious factors impact, allergens and aeroallergens, and in patients with recurrent obstructive bronchitis more important in the bronchial obstruction development were infectious agents and weather conditions worsening (high humidity, fog, rain). However, unlike the other factors involved in the bronchial obstruction development in asthma, nighttime, allergens and aeroallergens did not have significant impact on the bronchial obstruction occurrence in children with recurrent obstructive bronchitis. In both groups, physical stress (jogging, gymnastics) and emotional stress (loud laugh, crying) contributed to the bronchial obstruction syndrome development with the corresponding clinical picture, but in the second group of children with recurrent obstructive bronchitis duration of cough lasted 2 times less (1-1,5 h) than in children with bronchial asthma (over 3 hours).Conclusion. Conducted comparative characteristics showed that there is a clear link with the trigger mechanisms of bronchial obstruction occurrence in bronchial asthma and recurrent obstructive bronchitis, and triggers, regardless of the severity and duration of disease, have the same effect on the recurrent obstructive bronchitis outcome.
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Sheybani-Deloui, Sepideh, Lijun Chi, Marian V. Staite, Jason E. Cain, Brian J. Nieman, R. Mark Henkelman, Brandon J. Wainwright, et al. "Activated Hedgehog-GLI Signaling Causes Congenital Ureteropelvic Junction Obstruction." Journal of the American Society of Nephrology 29, no. 2 (November 6, 2017): 532–44. http://dx.doi.org/10.1681/asn.2017050482.

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Intrinsic ureteropelvic junction obstruction is the most common cause of congenital hydronephrosis, yet the underlying pathogenesis is undefined. Hedgehog proteins control morphogenesis by promoting GLI-dependent transcriptional activation and inhibiting the formation of the GLI3 transcriptional repressor. Hedgehog regulates differentiation and proliferation of ureteric smooth muscle progenitor cells during murine kidney-ureter development. Histopathologic findings of smooth muscle cell hypertrophy and stroma-like cells, consistently observed in obstructing tissue at the time of surgical correction, suggest that Hedgehog signaling is abnormally regulated during the genesis of congenital intrinsic ureteropelvic junction obstruction. Here, we demonstrate that constitutively active Hedgehog signaling in murine intermediate mesoderm–derived renal progenitors results in hydronephrosis and failure to develop a patent pelvic-ureteric junction. Tissue obstructing the ureteropelvic junction was marked as early as E13.5 by an ectopic population of cells expressing Ptch2, a Hedgehog signaling target. Constitutive expression of GLI3 repressor in Ptch1-deficient mice rescued ectopic Ptch2 expression and obstructive hydronephrosis. Whole transcriptome analysis of isolated Ptch2+ cells revealed coexpression of genes characteristic of stromal progenitor cells. Genetic lineage tracing indicated that stromal cells blocking the ureteropelvic junction were derived from intermediate mesoderm–derived renal progenitors and were distinct from the smooth muscle or epithelial lineages. Analysis of obstructive ureteric tissue resected from children with congenital intrinsic ureteropelvic junction obstruction revealed a molecular signature similar to that observed in Ptch1-deficient mice. Together, these results demonstrate a Hedgehog-dependent mechanism underlying mammalian intrinsic ureteropelvic junction obstruction.
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Sisniega, Carlos, and Umakanth Katwa. "Children with Upper Airway Dysfunction: At Risk of Obstructive Sleep Apnea." Journal of Child Science 09, no. 01 (January 2019): e59-e67. http://dx.doi.org/10.1055/s-0039-1688956.

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AbstractObstructive sleep apnea is characterized by prolonged partial upper airway obstruction or intermittent complete obstruction that disrupts normal ventilation during sleep and alters normal sleep patterns. Patients with obstructive sleep apnea tend to develop neurocognitive, cardiovascular, behavioral, attention issues, and poor academic performance. Therefore, it is essential to diagnose and treat obstructive sleep apnea early and avoid significant and long-lasting adverse outcomes. Most commonly, upper airway obstruction is caused by enlarged lymphoid tissues within the upper airway, and therefore adenotonsillectomy is considered as the first-line treatment of obstructive sleep apnea in children. Fifty to 70% of patients who have obstructive sleep apnea and treated by surgery are not entirely cured on follow-up polysomnography. In light of this, it is recommended that patients with suspected obstructive sleep apnea undergo a thorough evaluation, and all potential risk factors are identified and treated. The purpose of this review is to familiarize pediatricians with developmental, anatomical, and physiological risk factors involved in the development of obstructive sleep apnea. Additionally, we will present an array of evaluation techniques that can offer adequate assessment of the patient's upper airway anatomy and physiology.
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Rana, Surinder Singh, Ravi Sharma, Rajesh Gupta, and Sobur Uddin Ahmed. "Palliation of Obstructive Jaundice: Endoscopic Ultrasound‑guided Choledochoduodenostomy in the Presence of Bleeding Duodenal Infiltration Due to Metastatic Urinary Bladder Cancer." Journal of Digestive Endoscopy 09, no. 03 (July 2018): 118–21. http://dx.doi.org/10.4103/jde.jde_55_17.

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Obstructive jaundice is a common manifestation of malignancies involving pancreaticobiliary area of the gastrointestinal tract. The palliation of obstructive jaundice involves bypassing the obstruction by an endoprosthesis using either endoscopic retrograde cholangiopancreatography (ERCP) or percutaneous transhepatic biliary drainage route. Endoscopic ultrasound‑guided choledochoduodenostomy (ECD) is a challenging alternative for obstructive jaundice due to distal bile duct obstruction in patients who have failed ERCP. In this report, we describe a challenging case of disseminated urinary bladder cancer that presented with extensive duodenal as well as periduodenal infiltration leading on to gastrointestinal bleed and severe pruritus along with obstructive jaundice and was successfully managed with initial argon plasma coagulation of bleeding duodenal lesions followed by ECD.
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Dissertations / Theses on the topic "Obstructive"

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Shaikh, Zarrin F. "Patent foramen ovale in obstructive sleep apnoea and chronic obstructive pulmonary disease." Thesis, Imperial College London, 2011. http://hdl.handle.net/10044/1/9478.

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The objective of this thesis was to determine the impact of right to left shunting (RLS) through patent foramen ovale (PFO) on oxygen saturation in obstructive sleep apnoea (OSA) and chronic obstructive pulmonary disease (COPD). The first aim was to determine the prevalence of PFO in severe OSA and whether PFO closure improves nocturnal oxygen saturation. The data showed that PFO with large shunts were more prevalent, however overall prevalence was not statistically different when compared to healthy controls. PFO closure did not reduce nocturnal desaturation. The second aim was to determine whether severe COPD patients with PaO2 ≤ 7.3kPa had a higher prevalence of PFO compared to patients with PaO2 > 8kPa, additionally to compare the prevalence of PFO in COPD with healthy controls. The data showed no difference in PFO prevalence in patients with PaO2 ≤ 7.3kPa compared to patients with PaO2 > 8kPa, however, intrapulmonary shunts were more prevalent in hypoxaemic patients. Similar to OSA, PFO with large shunts were more prevalent in severe COPD, however overall prevalence was not statistically different to healthy controls. The final aim was to determine whether patients with COPD and PFO developed RLS during exercise and whether this was associated with reduced oxygen saturation, reduced exercise endurance and increased intrathoracic pressure swings. The data showed that RLS through PFO increased from baseline during exercise and this was associated with increased swings in intrathoracic pressure. There was no difference in desaturation or exercise endurance when compared to patients with no PFO. In summary, this thesis shows that PFO with large shunts are more prevalent in both OSA and COPD. PFO closure in OSA did not reduce nocturnal desaturation. Furthermore, the presence of a PFO in COPD did not influence resting or exercise oxygen saturation despite the observed increase in RLS with exercise.
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Derderian, Marc Gallinari Claude. "Bronchopneumopathie chronique obstructive (BPCO) du sujet âgé étude rétrospective /." Créteil : Université de Paris-Val-de-Marne, 2005. http://doxa.scd.univ-paris12.fr:80/theses/th0233033.pdf.

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Matsumoto, Takeshi. "Microalbuminuria in Patients with Obstructive Sleep Apnea-Chronic Obstructive Pulmonary Disease Overlap Syndrome." Kyoto University, 2018. http://hdl.handle.net/2433/232105.

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Turino, Cecilia. "A new approach to obstructive sleep apnoea management." Doctoral thesis, Universitat de Lleida, 2021. http://hdl.handle.net/10803/673267.

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L'aplicació de la pressió positiva contínua en la via aèria superior (CPAP) representa el mètode terapèutic de referència de la Síndrome d'Apnea Obstructiva del Son (SAOS). No obstant això, la SAOS es considera una malaltia amb múltiples fenotips i resposta al tractament variable. Per tant, el tractament amb CPAP hauria d'aconsellar-se segons el fenotip dels pacients. Així doncs, es necessiten noves estratègies per millorar el compliment del mateix tractament. En el primer article hem identificat algunes variables relacionades amb la SAOS . En el segon article hem definit el perfil general dels pacients de Catalunya tractats amb CPAP i hem identificat sis clústers de pacients amb diferents patrons de comorbiditats, mortalitat i ús dels recursos sanitaris. En el tercer article la telemedicina va demostrar més cost efectivitat que el maneig tradicional del tractament amb CPAP. En el quart article, el Sistema Intel•ligent de Monitoratge (MiSAOS) va demostrar més cost efectiu que el maneig tradicional del tractament amb CPAP.
La aplicación de la presión positiva continua en la vía aérea superior (CPAP) representa el método terapéutico de referencia del Síndrome de Apneas Obstructivas del Sueño (SAOS) . Sin embargo, el SAOS se considera una enfermedad con múltiples fenotipos, por lo tanto, el tratamiento con CPAP debería aconsejarse según el fenotipo de los pacientes. Por otro lado, también se necesita nuevas estrategias para mejorar el cumplimento del mismo tratamiento. En el primer artículo hemos identificado algunas variables relacionadas con el SAOS . En el segundo artículo hemos definido el perfil general de los pacientes SAOS de Cataluña tratados con CPAP y hemos identificado seis clústers de pacientes con diferentes patrones de comorbilidades, mortalidad y uso de los recursos sanitarios. En el tercer artículo la telemonitorización demostró más coste efectividad que el manejo tradicional del tratamiento con CPAP. En el cuarto artículo, el Sistema Inteligente de Monitorización (MiSAOS) del cumplimiento con CPAP se demostró más coste efectivo que el manejo tradicional.
The application of continuous positive pressure (CPAP) represents the first line treatment for patients with Obstructive Sleep Apnoea (OSA) . However, OSA is now regarded as a disorder characterized by multiple phenotypes with variable response to treatment. Thus, CPAP treatment should be recommended according to phenotypes. On the other hand, new methods for improving CPAP compliance are required. In the first article we found some variables associated with OSA . In the second article, we defined a general profile of the entire CPAP-treated OSA population of Catalonia and identified six patient groups characterized by different patterns of comorbidities, mortality, and healthcare resource use. In the third article telemedicine did not improve CPAP compliance but was more cost effective than traditional follow-up. Finally, in the fourth article, the MiSAOS Intelligent Monitoring System for improving CPAP compliance resulted more cost effective than traditional management.
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Murat, Sandrine. "Débit cardiaque : Influence dans le pronostic de la bronchopneumopathie chronique obstructive." Bordeaux 2, 2000. http://www.theses.fr/2000BOR2M035.

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Brousse, Christophe. "L'inflammation éosinophilique dans la bronchopneumopathie chronique obstructive et sa reversibilité aux corticoi͏̈des." Montpellier 1, 1994. http://www.theses.fr/1994MON11146.

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McPherson, G. A. D. "Biliary drainage in obstructive jaundice." Thesis, University of Oxford, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.375172.

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Bemelmans, Marcus Henricus Adrianus. "Inflammatory cytokines in obstructive jaundice." Maastricht : Maastricht : Universitaire Pers Maastricht ; University Library, Maastricht University [Host], 1994. http://arno.unimaas.nl/show.cgi?fid=6812.

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Gunaratnam, Kogulan. "OBSTRUCTIVE SLEEP APNOEA AND PERIODONTITIS." Thesis, Faculty of Dentistry, 2008. http://hdl.handle.net/2123/4057.

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Obstructive sleep apnoea (OSA) and its associated daytime symptoms form a syndrome, obstructive sleep apnoea-hypopnoea syndrome (OSAHS) that affects about 5% of the population worldwide (Young et al 2002a, Pack 2006). OSA is characterized by repeated episodes of upper airway obstruction during sleep, resulting in recurrent hypoxemia and sleep fragmentation (Hensley & Ray 2005). These in turn are associated with neurocognitive disorders, hypertension and cardiovascular complications (Pack 2006). Current therapies for this condition include surgical interventions, oral appliances and continuous positive airways pressure (CPAP). Systemic and local airway inflammation has recently been linked to OSA and is hypothesized to increase the risk of cardiovascular complications (Lavie 2005). While the exact mechanism is not certain, it is believed that the underlying systemic inflammation from OSA is due to the hypoxia/reperfusion injury from intermittent hypoxia that occurs with OSA (Lavie 2005). Specifically, the episodic hypoxia in OSA leads to increased production of reactive oxidative species (ROS) and, via various pathways, in the formation of systemic inflammatory mediators. The resultant inflammatory response is then responsible for the increased cardiovascular morbidity and mortality by potentiating disease in those that already have inflammatory disease or triggering inflammatory diseases in people with existing genetic, behavioural and environmental exposure. Periodontitis involves the supporting structures of the tooth and is a disease caused by specific bacteria that triggers an inflammatory response (Kinane 2001). Tissue damage and destruction, including loss of the connective tissue attachment between the tooth and the jaw, together with resorption of supporting bone, is initiated by the micro-organisms and mediated by the host response. Periodontitis, which is a severe form of periodontal disease, is one of the most common chronic infections in the world. The prevalence of moderate to severe periodontitis across the globe is in the range of 5 to 20 % (Burt 2005). Recent studies have speculated on an association between periodontitis and systemic inflammation in, for example, diabetes (Soskolne & Klinger 2001), rheumatoid arthritis (Mercado et al. 2000) and cardiovascular disease (CVD) (Beck & Offenbacher 2005), but no research has been undertaken on the link between OSA and periodontitis. This review will focus on features of OSA, inflammation and periodontitis to examine if there is a possible link between OSA and periodontitis by means of systemic inflammation.
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Noell, Guillaume. "Multi-Level Integrated Analysis of Chronic Obstructive Pulmonary Disease (COPD) heterogeneity." Doctoral thesis, Universitat de Barcelona, 2019. http://hdl.handle.net/10803/667980.

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Non-Communicable Diseases (NCDs), including cancer, cardiovascular (heart diseases or stroke), respiratory (COPD or asthma) and metabolic diseases (diabetes) are chronic conditions that represent a major global health problem of the 21st century. All of them, however, are the end-result of a complex set of gene-environment interactions that develop over years and often lead to several NCDs co-existing in the same individual (multi-morbidity). Multi-level integrated analysis has the potential to uncover the heterogeneity of NCDs by conceptualizing them as emergent properties of a complex, non-linear, dynamic and multilevel biological system, or network of biological and environmental interactions. Chronic Obstructive Pulmonary Disease (COPD) is a NCD of increasing prevalence worldwide that is projected to be by 2020 the third leading cause of death worldwide. It is currently viewed as a broad diagnostic term that encompass a continuum of subtypes each characterized by distinct functional or pathobiological mechanisms (endotypes) and is characterized by persistent respiratory symptoms and airflow limitation. The underlying hypothesis of this PhD Thesis is that multi-level integrated analysis can help us understand highly heterogeneous respiratory diseases such as COPD. Specifically, the following two aspects of COPD heterogeneity will be addressed: 1) Exacerbations of COPD (ECOPD): ECOPD are episodes of worsening of the symptoms whose pathogenesis and biology are not entirely understood. They are heterogeneous events of non-specific diagnosis. Biomarkers analysis and networks medicine were used to uncover novel pathobiological information from the comparison of the multi-level (i.e., clinical, physiological, biological, imaging and microbiological) correlation networks determined during ECOPD and clinical recover. We concluded that ECOPD are characterised by disruption of network homeokinesis that exists during convalescence and can be identified objectively by using a panel of three biomarkers (dyspnoea, circulating neutrophils and CRP levels) frequently determined in clinical practice. 2) Early low lung function and health in later life: In 2015 Lange P. et al. showed that low peak lung function in early adulthood is associated with the diagnosis of COPD later in life. We assessed in three general population cohorts the prevalence of low peak lung function and its association with other clinical or biological parameters - specifically respiratory, cardiovascular, and metabolic abnormalities – as well as incidence of comorbid diseases during follow-up. We concluded that low peak lung function in early adulthood is common in the general population and could identify a group of individuals at risk of early (cardiovascular, metabolic and systemic) comorbidities and premature death.
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Books on the topic "Obstructive"

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O’Reilly, P. H., ed. Obstructive Uropathy. London: Springer London, 1986. http://dx.doi.org/10.1007/978-1-4471-1380-5.

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Carter, Rick. Courage and information for life with chronic obstructive pulmonary disease: The handbook for patients, families, and care givers managing COPD (emphysema, asthmatic bronchitis, or chronic bronchitis). Onset, MA: New Technology Pub., 1999.

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A, Stockley Robert, ed. Chronic obstructive pulmonary disease. Malden, Mass: Blackwell Pub., 2005.

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Carr, Michele M. Pediatric obstructive sleep apnea. Alexandria, VA: American Academy Of Otolaryngology--Head and Neck Surgery Foundation, 2007.

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Currie, Graeme P. Chronic obstructive pulmonary disease. Oxford: Oxford University Press, 2009.

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Nakamura, Hiroyuki, and Kazutetsu Aoshiba, eds. Chronic Obstructive Pulmonary Disease. Singapore: Springer Singapore, 2017. http://dx.doi.org/10.1007/978-981-10-0839-9.

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Nici, Linda, and Richard ZuWallack, eds. Chronic Obstructive Pulmonary Disease. Totowa, NJ: Humana Press, 2012. http://dx.doi.org/10.1007/978-1-60761-673-3.

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Stockley, Robert A., Stephen I. Rennard, Klaus Rabe, and Bartolome Celli, eds. Chronic Obstructive Pulmonary Disease. Oxford, UK: Blackwell Publishing Ltd, 2007. http://dx.doi.org/10.1002/9780470755976.

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Calverley, P. M. A., and N. B. Pride, eds. Chronic Obstructive Pulmonary Disease. Boston, MA: Springer US, 1995. http://dx.doi.org/10.1007/978-1-4899-4525-9.

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Celli, Bartolome R., and Stephen I. Rennard. Chronic obstructive pulmonary disease. Philadelphia, Pennsylvania: Saunders, an imprint of Elsevier, Inc., 2012.

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Book chapters on the topic "Obstructive"

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McCaig, Fiona, James Tomlinson, and Mark Harber. "Acquired Urinary Tract Obstruction/Obstructive Uropathy." In Primer on Nephrology, 993–1017. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-76419-7_57.

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O’Reilly, P. H. "Introduction and General Considerations." In Obstructive Uropathy, 3–12. London: Springer London, 1986. http://dx.doi.org/10.1007/978-1-4471-1380-5_1.

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George, N. J. R. "Basic Considerations." In Obstructive Uropathy, 197–233. London: Springer London, 1986. http://dx.doi.org/10.1007/978-1-4471-1380-5_10.

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George, N. J. R. "Obstructive and Functional Abnormalities I." In Obstructive Uropathy, 235–75. London: Springer London, 1986. http://dx.doi.org/10.1007/978-1-4471-1380-5_11.

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George, N. J. R. "Obstructive and Functional Abnormalities II." In Obstructive Uropathy, 277–97. London: Springer London, 1986. http://dx.doi.org/10.1007/978-1-4471-1380-5_12.

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O’Reilly, P. H., and M. H. Jamison. "Practical Aspects of the Management of Lower Urinary Tract Obstruction." In Obstructive Uropathy, 299–320. London: Springer London, 1986. http://dx.doi.org/10.1007/978-1-4471-1380-5_13.

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Martin, P. J., and T. D. Brogan. "Laboratory Investigations." In Obstructive Uropathy, 13–30. London: Springer London, 1986. http://dx.doi.org/10.1007/978-1-4471-1380-5_2.

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O’Reilly, P. H., and D. Rickards. "Radiology." In Obstructive Uropathy, 31–57. London: Springer London, 1986. http://dx.doi.org/10.1007/978-1-4471-1380-5_3.

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O’Reilly, P. H. "Nuclear Medicine." In Obstructive Uropathy, 59–79. London: Springer London, 1986. http://dx.doi.org/10.1007/978-1-4471-1380-5_4.

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Rickards, D., and P. H. O’Reilly. "Antegrade Percutaneous Studies." In Obstructive Uropathy, 81–92. London: Springer London, 1986. http://dx.doi.org/10.1007/978-1-4471-1380-5_5.

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Conference papers on the topic "Obstructive"

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Cousins, M., K. Hart, C. Course, B. Radics, Z. Hantos, P. Sly, and S. Kotecha. "Oscillometry in preterm-associated obstructive and non-obstructive lung disease." In ERS International Congress 2022 abstracts. European Respiratory Society, 2022. http://dx.doi.org/10.1183/13993003.congress-2022.1702.

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Grossman, Peter R., Michelle Guzman, Jason P. Kirkness, Susheel P. Patil, Philip L. Smith, Alan R. Schwartz, and Hartmut Schneider. "Compensatory Responses To Upper Airway Obstruction In Chronic Obstructive Pulmonary Disease." In American Thoracic Society 2012 International Conference, May 18-23, 2012 • San Francisco, California. American Thoracic Society, 2012. http://dx.doi.org/10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a3994.

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Gardner, Zechariah S., David A. Kaminsky, and Gregg L. Ruppel. "Grading The Severity Of Obstruction In Mixed Obstructive-Restrictive Lung Disease." In American Thoracic Society 2010 International Conference, May 14-19, 2010 • New Orleans. American Thoracic Society, 2010. http://dx.doi.org/10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a2107.

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Gell, L., D. Vena, A. Azarbarzin, N. Calianese, L. Hess, L. Taranto Montemurro, D. White, D. A. Wellman, and S. A. Sands. "Ventilatory Drive-Dependent Obstruction as the Predominant Phenotype of Obstructive Sleep Apnea." In American Thoracic Society 2020 International Conference, May 15-20, 2020 - Philadelphia, PA. American Thoracic Society, 2020. http://dx.doi.org/10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a4518.

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Jaradat, O., A. Osenga, G. Anders, and L. Olson. "Obstructive Sleep Apnea Screening." In American Thoracic Society 2020 International Conference, May 15-20, 2020 - Philadelphia, PA. American Thoracic Society, 2020. http://dx.doi.org/10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a4149.

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Manukyan, Aikush S., Irina V. Muzychenko, Tamara S. Popova, Elena A. Khomenko, and Tatiana A. Kosenchuk. "Obstructive sleep apnea syndrome." In Актуальные вопросы оториноларингологии. Благовещенск: Амурская государственная медицинская академия, 2022. http://dx.doi.org/10.22448/9785604863312_167.

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Greenberg Dotan, Sari, Haim Reuveni, Asher Tal, Arie Oksenberg, Arnon Cohen, Fadia Shaya, Ariel Tarasiuk, and Steven Scharf. "Increased Prevalence Of Obstructive Lung Disease In Patients With Obstructive Sleep Apnea." In American Thoracic Society 2011 International Conference, May 13-18, 2011 • Denver Colorado. American Thoracic Society, 2011. http://dx.doi.org/10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a1497.

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Al-Jumaily, A. M., S. Ashaat, B. A. Martin, R. Heinzer, J. Haba Rubio, and N. Stergiopulos. "Uvula Dynamic Characteristics." In ASME 2013 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/sbc2013-14019.

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The airway binary fluid layer and the structural characteristics of the upper airways have significant influence on the activity of the airway muscles by changing airway compliance and collapsibility during obstructive sleep apnea trauma. The uvula plays an important role in the collapse process. Using MRI scans, this paper develops a structural model for the uvula and determines its dynamic characteristics in terms of natural frequencies and mode shapes as a preliminary process to determine optimum conditions to therapeutically relieve upper airway obstruction. The effect of the variation of tissue elasticity due to water content is elaborated on.
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Neffati, O., H. Zaibi, B. Dhahri, J. Ben Ammar, M. A. Baccar, S. Azzabi, and H. Aouina. "Obstructive sleep apnoea and hypothyroidism." In Annual Congress 2015. European Respiratory Society, 2015. http://dx.doi.org/10.1183/13993003.congress-2015.pa2366.

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Sesemann, L. "Bradyarrhythmias in Obstructive Sleep Apnea." In American Thoracic Society 2021 International Conference, May 14-19, 2021 - San Diego, CA. American Thoracic Society, 2021. http://dx.doi.org/10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a4697.

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Reports on the topic "Obstructive"

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Czerwaty, Katarzyna, Karolina Dżaman, Krystyna Maria Sobczyk, and Katarzyna Irmina Sikrorska. The Overlap Syndrome of Obstructive Sleep Apnea and Chronic Obstructive Pulmonary Disease: A Systematic Review. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, November 2022. http://dx.doi.org/10.37766/inplasy2022.11.0077.

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Review question / Objective: To provide the essential findings in the field of overlap syndrome of chronic obstructive pulmonary disease and obstructive sleep apnea, including prevalence, possible predictors, association with clinical outcomes, and severity compared to both chronic obstructive pulmonary disease and obstructive sleep apnea patients. Condition being studied: OSA is characterized by complete cessation (apnea) or significant decrease (hy-popnea) in airflow during sleep and recurrent episodes of upper airway collapse cause it during sleep leading to nocturnal oxyhemoglobin desaturations and arousals from rest. The recurrent arousals which occur in OSA lead to neurocognitive consequences, daytime sleepiness, and reduced quality of life. Because of apneas and hypopneas, patients are experiencing hypoxemia and hypercapnia, which result in increasing levels of catecholamine, oxidative stress, and low-grade inflammation that lead to the appearance of cardio-metabolic consequences of OSA. COPD is a chronic inflammatory lung disease defined by persistent, usually pro-gressive AFL (airflow limitation). Changes in lung mechanics lead to the main clini-cal manifestations of dyspnea, cough, and chronic expectoration. Furthermore, patients with COPD often suffer from anxiety and depression also, the risk of OSA and insomnia is higher than those hospitalized for other reasons. Although COPD is twice as rare as asthma but is the cause of death eight times more often.
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Torres-Castro, Rodrigo, Lilian Solis-Navarro, Homero Puppo, Roberto Vera-Uribe, Victoria Alcaraz-Serrano, and Jordi Vilaró. Respiratory muscle training in patients with obstructive sleep apnea: A systematic review and meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, February 2022. http://dx.doi.org/10.37766/inplasy2022.2.0096.

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Review question / Objective: Is respiratory muscle training effective in patients with obstructive sleep apnea? Condition being studied: Effects of respiratory muscle training in patients with obstructive sleep apnea. Information sources: We included the following databases: Pubmed, CENTRAL, Web of Science, CINAHL, EMBASE, Scopus and Scielo. Additionally, the references list of the included studies will be manually reviewed.
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Liu, Lu, Wenchuan Qi, Qian Zeng, Ziyang Zhou, Daohong Chen, Lei Gao, Bin He, Dingjun Cai, and Ling Zhao. Does acupuncture improve lung function in chronic obstructive pulmonary disease animal model?: a systematic review and meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, March 2022. http://dx.doi.org/10.37766/inplasy2022.3.0104.

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Review question / Objective: Chronic obstructive pulmonary disease (COPD) is a common, preventable, and treatable disease characterized by persistent respiratory symptoms and progressive airflow obstruction documented on spirometry. Acupuncture, as a safe and economical non-pharmacology therapy, has pronounced therapeutic effects in COPD patients. Several systematic reviews draw the conclusion that acupuncture could improve patients’ quality of life, exercise capacity and dyspnoea, however, the results about lung function were inconclusive. Recently, increasing number of animal studies has been published to illustrate the effects of acupuncture in improving lung function in COPD animal model. However, the efficacy of acupuncture for experimentally induced COPD have not been systematically investigated yet. A systematic review of animal experiments can benefit future experimental designs, promote the conduct and report of basic researches and provide some guidance to translate the achievements of basic researches to clinical application in acupuncture for COPD. Therefore, we will conduct this systematic review and meta-analysis to evaluate effects of acupuncture on COPD animal model.
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Hazboun, Tawfiq N. Obstructive Sleep Apnea Oral Appliance vs. Auto Titrating Positive Airway Pressure. Fort Belvoir, VA: Defense Technical Information Center, June 2013. http://dx.doi.org/10.21236/ad1012981.

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Yu, Zhixiang, Qiuhe Ji, Fu Yi, and Jinxiang Cheng. Association Between Obstructive Sleep Apnoea And T2DM: A Dose-Response Meta-Analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, November 2020. http://dx.doi.org/10.37766/inplasy2020.11.0027.

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N Chui, Juanita, William A Ziaziaris, Ali Mohtashami, Christopher SH Lim, Nazim Bhimani, and Thomas J Hugh. Biliary Metastases from Colon Cancer: A Rare Differential Diagnosis for Obstructive Jaundice. Science Repository, December 2022. http://dx.doi.org/10.31487/j.ajscr.2022.03.03.

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Metastatic infiltration of the biliary tree is a rare manifestation of colorectal cancer. Currently, there is limited evidence to inform the management of such cases and the prognosis is poor. Herein, we report a case of biliary colorectal metastases with extensive multifocal involvement and discuss the challenges of the diagnosis and treatment.
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Torres, Claudia Fernandez, and Alvaro Zubizarreta Macho. Mandibular advancement appliances to treat apnea: an update of the most used currently. A systematic review and meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, November 2022. http://dx.doi.org/10.37766/inplasy2022.11.0034.

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Review question / Objective: Mandibular advancement devices used to treat obstructive sleep apnea. Condition being studied: Obstructive sleep apnea is characterized by episodes of a complete (apnea) or partial collapse (hypopnea) of the upper airway with an associated decrease in oxygen saturation or arousal from sleep. This disturbance results in fragmented, nonrestorative sleep. Other symptoms include loud, disruptive snoring, witnessed apneas during sleep, and excessive daytime sleepiness. OSA has significant implications for cardiovascular health, mental illness, quality of life, and driving safety.
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Sun, Dong, Yanan Zhang, and Di Zhou. The relationship between obstructive sleep apnea and retinal vein occlusion : a Meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, February 2022. http://dx.doi.org/10.37766/inplasy2022.2.0068.

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Lu, Jiyuan, Lingdan Xu, Yanduo Yang, Yucheng Meng, Yi Li, Huihui Wang, and Bin Liu. Obstructive sleep apnea and serum total testosterone: a system review and meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, March 2022. http://dx.doi.org/10.37766/inplasy2022.3.0110.

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Chen, Cheng, Shangren Wang, Aiqiao Zhang, Li Liu, Zhexin Zhang, Shuai Niu, Yuxuan Song, Yang Pan, and Xiaoqiang Liu. Association of polymorphisms in estrogen receptors with non-obstructive azoospermia and severe oligospermia. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, October 2022. http://dx.doi.org/10.37766/inplasy2022.10.0034.

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