Dissertations / Theses on the topic 'Nucleotides binding'
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Herzog, Mario. "Thermophoresis and cooperative binding of nucleotides." Diss., lmu, 2012. http://nbn-resolving.de/urn:nbn:de:bvb:19-149751.
Full textJohansson, Kenth. "Structural studies of four nucleotide binding proteins : aldehyde dehydrogenase, NADP-malate dehydrogenase and two deoxynucleoside kinases /." Uppsala : Swedish University of Agricultural Sciences, 2000. http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&doc_number=009416200&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA.
Full textKennedy, Eileen Jeanne. "Understanding modulation of nucleotide binding by PKA and regulation of extracellular nucleotides in saccharomyces cerevisiae /." Diss., Connect to a 24 p. preview or request complete full text in PDF formate. Access restricted to UC campuses, 2005. http://wwwlib.umi.com/cr/ucsd/fullcit?p3208636.
Full textWorth, Graham Alan. "The energetics of nucleotide binding to RAS proteins." Thesis, University of Oxford, 1992. http://ora.ox.ac.uk/objects/uuid:44524415-2f2b-4601-998c-56110f332153.
Full textHerzog, Mario [Verfasser], and Dieter [Akademischer Betreuer] Braun. "Thermophoresis and cooperative binding of nucleotides / Mario Herzog. Betreuer: Dieter Braun." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2012. http://d-nb.info/1027669522/34.
Full textLaw, Wing-lun, and 羅永倫. "Expression, purification and preliminary x-ray crystallographic studies of two nucleotide binding proteins." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B46939118.
Full textPeake, Sarah Jayne. "Structure and function of the NADP(H)-binding component (dIII) of human heart transhydrogenase." Thesis, University of Birmingham, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.367626.
Full textJeans, David Richard. "Properties of the nucleotide binding sites of the Ca²⁺-ATPase of sarcoplasmic reticulum." Master's thesis, University of Cape Town, 1988. http://hdl.handle.net/11427/26592.
Full textMontgomery, Kyle Everett. "MOLECULAR FACTORS THAT INFLUENCE THE BINDING OF AGONISTS TO AMPA RECEPTORS." OpenSIUC, 2009. https://opensiuc.lib.siu.edu/dissertations/297.
Full textAung-Htut, May Thandar Biotechnology & Biomolecular Sciences Faculty of Science UNSW. "Characterisation of Escherichia coli GTPase Der reveals previously unknown regulation by RNA." Publisher:University of New South Wales. Biotechnology & Biomolecular Sciences, 2008. http://handle.unsw.edu.au/1959.4/41840.
Full textSeebregts, Christopher J. "Photoaffinity labeling the nucleotide sites of the sarcoplasmic reticulum Ca²⁺-ATPase." Doctoral thesis, University of Cape Town, 1989. http://hdl.handle.net/11427/27167.
Full textSehgal, Rippa. "Binding of Oxaliplatin and its Analogs with DNA Nucleotides at Variable pH and Concentration Levels." TopSCHOLAR®, 2016. http://digitalcommons.wku.edu/theses/1602.
Full textDavidson, George Alexander. "Properties of the non-catalytic nucleotide site of the Ca²⁺-ATPase of sarcoplasmic reticulum." Doctoral thesis, University of Cape Town, 1986. http://hdl.handle.net/11427/27199.
Full textDahan, Albert. "Receptor binding of somatostatin-14 and somatostatin-28 in rat brain differential modulation by nucleotides and ions." Thesis, McGill University, 1986. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=66121.
Full textHatcher, Mary Elana. "A solid-state deuterium NMR investigation of the local dynamics of nucleotides in the EcoRI restriction endonuclease binding site /." Thesis, Connect to this title online; UW restricted, 1996. http://hdl.handle.net/1773/8640.
Full textShyy, Yeun-Jund. "Nuclear magnetic resonance studies on the interaction of metal ions with adenine nucleotides and substrates binding to adenylate kinase /." The Ohio State University, 1987. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487329662147312.
Full textLevine, Kara B. "Identification of the Human Erythrocyte Glucose Transporter (GLUT1) ATP Binding Domain: A Dissertation." eScholarship@UMMS, 1999. https://escholarship.umassmed.edu/gsbs_diss/247.
Full textButler, Michelle Marie. "Probing the dNTP Binding Region of Bacillus subtilis: DNA Polymerase III with Site-Directed Inhibitors: A Dissertation." eScholarship@UMMS, 1992. https://escholarship.umassmed.edu/gsbs_diss/132.
Full textLin, Chien-Ling. "Studies on the Regulation of Cytoplasmic Polyadenylation Element-Binding Protein: A Dissertation." eScholarship@UMMS, 2012. https://escholarship.umassmed.edu/gsbs_diss/583.
Full textMadera, Dmitri. "Cooperating Events in Core Binding Factor Leukemia Development: A Dissertation." eScholarship@UMMS, 2011. https://escholarship.umassmed.edu/gsbs_diss/532.
Full textTisi, Dominic John Guiseppe. "Structural studies on nucleotide binding proteins." Thesis, Birkbeck (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.391822.
Full textBelk, Jonathan Philip. "A Characterization of Substrates and Factors Involved in Yeast Nonsense-Mediated mRNA Decay: A Dissertation." eScholarship@UMMS, 2002. https://escholarship.umassmed.edu/gsbs_diss/65.
Full textMutomba, Martha Chengetai. "Guanine nucleotide-binding proteins of Trypanosoma brucei." Thesis, University of Cambridge, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.308280.
Full textSchrift, Greta Lynn. "Energetic consequences of structural features and dynamics changes upon nucleotide binding to ribonuclease SA molecular basis for nucleotide binding specificity /." Diss., University of Iowa, 2004. http://ir.uiowa.edu/etd/120.
Full textIuga, Adriana. "Solid-state 31P NMR of nucleotide binding proteins." [S.l. : s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=973225238.
Full textHeurtel, Thuswaldner Sophie. "Nucleotide-binding Proteins in the Plant Thylakoid Membrane." Licentiate thesis, Linköping Department of Biomedicine and Surgery, Linköping University, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-7934.
Full textRaper, Jayne. "Guanine nucleotide binding protein function in T.B. Brucei." Thesis, University of Cambridge, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.305533.
Full textKakraba, Samuel. "A Hierarchical Graph for Nucleotide Binding Domain 2." Digital Commons @ East Tennessee State University, 2015. https://dc.etsu.edu/etd/2517.
Full textSmith, James. "Molecular discrimination analysis for purine nucleotide binding sites." Thesis, University of Cambridge, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.620247.
Full textGraham, Heidi C. "Nuclear magnetic resonance studies of a kinase : 3-phosphoglycerate kinase (PGK)." Thesis, University of Oxford, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.334917.
Full textRodrigues, Daniel Joseph. "Structure-function relationships in the NADP (H) binding component of proton-translocating transhydrogenase from Rhodospirillum rubrum." Thesis, Oxford Brookes University, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.289256.
Full textBlanco, Barrera José Antonio. "Structural analysis of nucleotide binding sites of antimicrobial ribonucleases." Doctoral thesis, Universitat Autònoma de Barcelona, 2015. http://hdl.handle.net/10803/311613.
Full textThis thesis encompasses the structural and functional analysis of antimicrobial ribonucleases. Nucleotide-type ligand interaction sites have been analysed using RNase A as a reference protein. RNase complexes were analysed by statistical structural analysis and X-ray crystallography. Together with the catalytic triad, other secondary interaction subsites were also defined at the protein surface. The RNase A superfamily embraces ribonucleases with diverse functions not necessarily related to RNase activity. In particular, antimicrobial properties are ascribed to members with high isoelectric point values, which also explain their stability and high affinity to membrane components. However, a noticeably lower RNase activity is seen for cationic RNases owing to the lack of key residues important for the correct substrate alignment. The different nucleotide-type substrate binding and recognition patterns were deduced from an overall structure complex statistics’ analysis and compared to the particular traits of selected families of representative endoribonucleases . A large amount of mono- and dinucleotide protein complexes was analysed. The results provided a general model of protein-nucleotide interactions for cytotoxic endoribonucleases. The identification of amino acids and atoms frequently involved in the recognition interactions defined three-dimensional motifs for phosphate, ribose and bases in the RNase A superfamily. Together with the conserved catalytic triad at the active site, residue variability is commonly observed throughout the secondary binding subsites, in agreement with the RNase preferential binding patterns, the different alignment capability, substrate specificity and variable catalytic efficiency. Results were complemented with molecular modelling predictions and evolution comparisons by sequence alignment and structural overlapping. A final side-by-side comparison with the microbial RNase T1 superfamily has allowed an analysis of the common and particular features of substrate recognition processes, thereby building a general interaction architecture applicable to recognition for polyanionic biomolecules that may set a structural basis for the design of new drugs. Additionally, structural studies by X-ray crystallography were carried out. Recombinant wild-type RNases (RNase A, RNase 3, RNase 6) and mutant variants were expressed and purified in a high-yield prokaryotic system andtheir crystal structures were solved. In particular, a crystallisation condition has been discovered for human RNase 6. We report here the first crystal structure of RNase 6, which sets the basis for further analysis of interactions with nucleotide molecules and other putative ligands. On the other hand, the structural analysis of an RNase A mutant (RNase A/H7H10), where the secondary phosphate binding site p2 has been converted into a second active site, in complex with 3’-CMP, enabled the visualisation of induced neighbouring conformational changes. A second RNase A – 3’-CMP complex, obtained at atomic resolution, has enabled a more detailed comparative analysis with lower-resolution protein-nucleotide complexes together with a side-by-side study of subsite environments with the mutant complex, explaining the mutant catalytic properties. The additional visualisation of the protonation state of the active site residues has also provided information about the mechanism of catalysis. Following, two RNase 3/ECP active site mutants (ECP/H15A, ECP/H128N) were crystallised. Structural studies confirmed the conservation of the protein overall three dimensional structure together with previous kinetic experiments related to the abolished catalytic activity. Also, two native ECP crystals obtained by two distinct crystallization conditions were used for a comparison of the different unit cell packing, residue side chain variability and anion recognition sites. Finally, the structures of RNase A, RNase 3/ECP and RNase 6 with bound sulphate anions were compared, and their putative anion recognition sites characterized. The comparison of the binding subsites confirmed the higher affinity of RNase 3/ECP for sulphate/ phosphate anionsand may lead to the identification of protein regions prone to host nucleotides or heterosaccharide compounds.
De, Wet Heidi. "The nucleotide binding domains of multidrug resistance-p-glycoproteins." Doctoral thesis, University of Cape Town, 2001. http://hdl.handle.net/11427/2690.
Full textWatson, Dorothy M. A. "Cyclic nucleotide binding and oncogene expression in breast cancer." Thesis, University of Edinburgh, 1989. http://hdl.handle.net/1842/19398.
Full textChow, Sarah Sue Wen. "Energetic and structural impact of cyclic nucleotide binding to hyperpolarization-activated cyclic nucleotide-gated channels." Thesis, University of British Columbia, 2013. http://hdl.handle.net/2429/44980.
Full textDunaway, Adam Blake. "Characterization of the binding activity of immobilized DNA aptamers for nucleotide and non-nucleotide targets." Thesis, Georgia Institute of Technology, 2014. http://hdl.handle.net/1853/54310.
Full textBramble, Sharyl Elizabeth. "Guanine nucleotide binding properties and attempted immunopurification of ras protein from dictyostelium discoideum." Thesis, University of British Columbia, 1987. http://hdl.handle.net/2429/26172.
Full textScience, Faculty of
Microbiology and Immunology, Department of
Graduate
Gao, Enoch N. (Enoch Nuo). "Post-translational lipid modification and nucleotide binding of Myelin 2',3'-Cyclic Nucleotide 3'-Phosphodiesterase (CNP)." Thesis, McGill University, 1996. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=23889.
Full textLaine, Jennifer M. "Protein Ligand Interactions Probed by NMR: A Dissertation." eScholarship@UMMS, 2012. https://escholarship.umassmed.edu/gsbs_diss/617.
Full textDe, Zutter Julie Kelley. "Allosteric Regulation of Recombination Enzymes E. coli RecA and Human Rad51: A Dissertation." eScholarship@UMMS, 2000. https://escholarship.umassmed.edu/gsbs_diss/192.
Full textGuy, E. C. "Nucleotide binding to type-M1̲ pyruvate kinase from rabbit muscle." Thesis, University of Southampton, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.235158.
Full textYakamavich, Joseph Andrew. "Control of HslUV protease function by nucleotide binding and hydrolysis." Thesis, Massachusetts Institute of Technology, 2007. http://hdl.handle.net/1721.1/42397.
Full textThesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, February 2008.
Many proteins act as molecular machines, using the power of nucleotide binding and hydrolysis to drive conformational changes in themselves and their target substrates. Like other AAA+ proteases, HslUV recognizes, unfolds, translocates, and degrades substrate proteins in an ATP-dependent manner. Understanding how nucleotides interact with HslU and control the activities of both HslU and HslV provides insights into the general mechanism of energy-dependent proteolysis. In order to better understand HslU-nucleotide interactions, I created a variant of HslU unable to hydrolyze ATP. HslU is composed of six identical subunits with a total of six nucleotide-binding sites. Moreover, many crystal structures show HslU with six bound nucleotides. Nevertheless, I found that HslU in solution is only able to bind 3-4 ATPs at saturation. This result rules out a model of ATP hydrolysis in which six nucleotides bind and are hydrolyzed together in a single power stroke and also suggests that many HslU crystal structures represent states that are not populated in the normal ATPase cycle. I also characterized the nucleotide requirement for various HslU activities. I found that at least two ATPs must be bound to HslU to support substrate binding and ATP hydrolysis, but showed that a single nucleotide is sufficient to support HslU-HslV binding and to stimulate HslV peptidase activity. I also found that the nucleotide state of HslU affects its affinity to HslV, weakening it when some subunits have ADP or no nucleotide bound. This effect is offset by an increase in HslU-HslV affinity during substrate degradation. This work suggests a simple model in which binding of a single ATP to HslU drives HslV binding, with further ATP binding acting to stabilize an HslU conformation that can bind protein substrate, hydrolyze ATP, and support substrate unfolding, translocation, and degradation.
by Joseph Andrew Yakamavich.
Ph.D.
Pagano, John M. Jr. "RNA Recognition by the Caenorhabditis elegans Embryonic Determinants MEX-5 and MEX-3: A Dissertation." eScholarship@UMMS, 2010. https://escholarship.umassmed.edu/gsbs_diss/486.
Full textBurns, David M. "Post-Transcriptional Control of Human Cellular Senescence: A Dissertation." eScholarship@UMMS, 2010. https://escholarship.umassmed.edu/gsbs_diss/491.
Full textMaurer, Brigitte. "Expression and purification of the nucleotide binding domains of P-glycoprotein." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp05/MQ63109.pdf.
Full textDelannoy, Sabine. "Structure-function relationship in the nucleotide-binding domains of ABC transporters." Ann Arbor, Mich. : ProQuest, 2007. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3244455.
Full textTitle from PDF title page (viewed Mar. 18, 2008). Source: Dissertation Abstracts International, Volume: 67-12, Section: B, page: 6885. Adviser: Pia D. Vogel. Includes bibliographical references.
Saiu, P. "Structural and functional studies on nucleotide binding to AMP-activated protein kinase." Thesis, University College London (University of London), 2010. http://discovery.ucl.ac.uk/645676/.
Full textAkam, Elizabeth Claire. "The activation of guanine nucleotide binding proteins by muscarinic acetylcholine receptor subtypes." Thesis, University of Leicester, 1999. http://hdl.handle.net/2381/29919.
Full textGorman, Christine. "The interaction of Ras with Raf and other potential effectors." Thesis, Imperial College London, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.312373.
Full textGrondin, Ronald Thomas. "Expression, purification, refolding, and ATP binding of the first nucleotide binding domain of the cystic fibrosis transmembrane conductance regulator." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp04/mq29275.pdf.
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