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Relevant bibliographies by topics / Nucleoside antibiotic synthesis

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Academic literature on the topic 'Nucleoside antibiotic synthesis'

Author: Grafiati

Published: 4 June 2021

Last updated: 11 February 2022

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Journal articles on the topic "Nucleoside antibiotic synthesis"

1

Ubukata, Makoto, and Kiyoshi Isono. "Total synthesis of nucleoside antibiotic. Ascamycin." Tetrahedron Letters 27, no. 33 (January 1986): 3907–8. http://dx.doi.org/10.1016/s0040-4039(00)83912-x.

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Nie, Shenyou, Wei Li, and Biao Yu. "Total Synthesis of Nucleoside Antibiotic A201A." Journal of the American Chemical Society 136, no. 11 (March 11, 2014): 4157–60. http://dx.doi.org/10.1021/ja501460j.

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3

Xiao, Guozhi, and Haiqing He. "Chemical Synthesis of the Nucleoside Antibiotic Capuramycin." European Journal of Organic Chemistry 2021, no. 26 (July 8, 2021): 3681–89. http://dx.doi.org/10.1002/ejoc.202100613.

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4

FEDUCHI, ELENA, MONTSE COSIN, and LUIS CARRASCO. "Mildiomycin: A nucleoside antibiotic that inhibits protein synthesis." Journal of Antibiotics 38, no. 3 (1985): 415–19. http://dx.doi.org/10.7164/antibiotics.38.415.

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5

Pletzer, Daniel, Yvonne Braun, Svetlana Dubiley, Corinne Lafon, Thilo Köhler, Malcolm G. P. Page, Michael Mourez, Konstantin Severinov, and Helge Weingart. "The Pseudomonas aeruginosa PA14 ABC Transporter NppA1A2BCD Is Required for Uptake of Peptidyl Nucleoside Antibiotics." Journal of Bacteriology 197, no. 13 (April 27, 2015): 2217–28. http://dx.doi.org/10.1128/jb.00234-15.

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ABSTRACTAnalysis of the genome sequence ofPseudomonas aeruginosaPA14 revealed the presence of an operon encoding an ABC-type transporter (NppA1A2BCD) showing homology to the Yej transporter ofEscherichia coli. The Yej transporter is involved in the uptake of the peptide-nucleotide antibiotic microcin C, a translation inhibitor that targets the enzyme aspartyl-tRNA synthetase. Furthermore, it was recently shown that the Opp transporter fromP. aeruginosaPAO1, which is identical to Npp, is required for uptake of the uridyl peptide antibiotic pacidamycin, which targets the enzyme translocase I (MraY), which is involved in peptidoglycan synthesis. We used several approaches to further explore the substrate specificity of the Npp transporter. Assays of growth in defined minimal medium containing peptides of various lengths and amino acid compositions as sole nitrogen sources, as well as Biolog Phenotype MicroArrays, showed that the Npp transporter is not required for di-, tri-, and oligopeptide uptake. Overexpression of thenppoperon increased susceptibility not just to pacidamycin but also to nickel chloride and the peptidyl nucleoside antibiotic blasticidin S. Furthermore, heterologous expression of thenppoperon in ayej-deficient mutant ofE. coliresulted in increased susceptibility to albomycin, a naturally occurring sideromycin with a peptidyl nucleoside antibiotic. Additionally, heterologous expression showed that microcin C is recognized by theP. aeruginosaNpp system. Overall, these results suggest that the NppA1A2BCD transporter is involved in the uptake of peptidyl nucleoside antibiotics byP. aeruginosaPA14.IMPORTANCEOne of the world's most serious health problems is the rise of antibiotic-resistant bacteria. There is a desperate need to find novel antibiotic therapeutics that either act on new biological targets or are able to bypass known resistance mechanisms. Bacterial ABC transporters play an important role in nutrient uptake from the environment. These uptake systems could also be exploited by a Trojan horse strategy to facilitate the transport of antibiotics into bacterial cells. Several natural antibiotics mimic substrates of peptide uptake routes. In this study, we analyzed an ABC transporter involved in the uptake of nucleoside peptidyl antibiotics. Our data might help to design drug conjugates that may hijack this uptake system to gain access to cells.

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Nie, Shenyou, Wei Li, and Biao Yu. "ChemInform Abstract: Total Synthesis of Nucleoside Antibiotic A201A." ChemInform 45, no. 43 (October 10, 2014): no. http://dx.doi.org/10.1002/chin.201443207.

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7

Castro-Pichel, Julia, M. Teresa García-López, Federico G. De las Heras, and Rosario Herranz. "Synthesis of pyrimidine analogues of the nucleoside antibiotic ascamycin." Liebigs Annalen der Chemie 1988, no. 8 (August 16, 1988): 737–42. http://dx.doi.org/10.1002/jlac.198819880805.

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8

Kondo, Tadao, Kaoru Okamoto, Manabu Yamamoto, Toshio Goto, and Ngbuo Tanaka. "A total synthesis of cadeguomycin, a nucleoside antibiotic produced by." Tetrahedron 42, no. 1 (January 1986): 199–205. http://dx.doi.org/10.1016/s0040-4020(01)87418-4.

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9

Patel, Bhautikkumar, Gary Grant, Matthew Zunk, and Santosh Rudrawar. "Stereoselective Approaches toward the Synthesis of Nucleoside Antibiotic Core Aminoribosyl Glycyluridine." European Journal of Organic Chemistry 2019, no. 35 (July 10, 2019): 6005–15. http://dx.doi.org/10.1002/ejoc.201900708.

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10

More, Jesse D., and Nathaniel S. Finney. "Synthesis of the Bicyclic Core of the Nucleoside Antibiotic Octosyl Acid A." Journal of Organic Chemistry 71, no. 6 (March 2006): 2236–41. http://dx.doi.org/10.1021/jo052025s.

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Dissertations / Theses on the topic "Nucleoside antibiotic synthesis"

1

Howard, P. N. "Synthetic studies on sinefungin." Thesis, University of Oxford, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.376917.

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Gethin, David Morris. "Towards the novel enantioselective synthesis of the nucleoside antibiotic, polyoxin J." Thesis, University of Nottingham, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.363937.

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3

Michailidou, Freideriki. "Structural and mechanistic studies on the biosynthesis of the 3'-deoxy nucleoside of the pacidamycins." Thesis, University of St Andrews, 2018. http://hdl.handle.net/10023/15668.

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Nucleic acids are ubiquitous in nature and modified nucleosides are present in a wide range of anti-viral, anti-cancer drugs and antibiotics. Although a variety of naturally occurring nucleoside analogues exist, few include modifications to the ribose or deoxyribose ring. Intriguingly, the uridyl peptide antibiotics (UPAs), such as pacidamycin, contain a biosynthetically unique 3'-deoxyuridine which resembles synthetic anti-retrovirals. Elucidation of the biosynthesis of this structuraly unique nucleoside motif suggests a degree of substrate flexibility, making it a highly attractive prospect for biosynthetic approaches to nucleoside modification. In order to fully exploit the biotransformative potential, a detailed mechanistic understanding of the individual enzymes involved in the biosynthesis of the nucleoside moiety, and especially the enzyme employed at the installation of the 3'-deoxy modification, is required. Chapter 1, the introduction the thesis, discusses the importance of nucleosides for Chemistry and Biology. The section describes the biosynthesis of the nucleoside antibiotics and reviews the recent advances relating to the synthesis and biosynthesis of 3'-deoxy-nucleosides. The Chapter proceeds to describes the biosynthesis of deoxy-sugars, deoxy-nucleosides and nucleotides, reviewing the most common dehydratase mechanisms in addition to examining unusual dehydratases involved in carbohydrate metabolism. Chapter 2, the study of Pac13, the uridine-5'-aldehyde dehydratase of the pacidamyicin nucleoside cluster, is reported. Through detailed functional, structural and kinetic analysis of the wild-type enzyme as well a series of mutants, Chapter 2 provides insight into the mechanism emplyed by this unusual enzyme. Chapter 3 describes the structural and functional analysis of Pac11, the flavin-dependent oxidoreductase of the nucleoside biosynthetic cluster, while Chapter 4 revolves around Pac5, the PLP-dependent aminotransferase. In Chapter 5, the chemical synthesis of fluorinated nucleosides, as probes for exploring the enzymes' mechanism is investigated. Chapter 7 reports the experimental procedures for the research described in this document. The work described in this thesis broadens the understanding of the biosynthesis of deoxy-nucleosides and constitutes the first structural and mechanistic study of the biosynthesis of the biosynthesis of the valuable yet, synthetically challenging 3'-deoxy nucleosides.

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4

Leyerer, Kristin [Verfasser], and Christian [Akademischer Betreuer] Ducho. "Muraymycin nucleoside antibiotics : novel SAR Insights and synthetic approaches / Kristin Leyerer ; Betreuer: Christian Ducho." Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2018. http://d-nb.info/1192754778/34.

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Leyerer, Kristin Verfasser], and Christian [Akademischer Betreuer] [Ducho. "Muraymycin nucleoside antibiotics : novel SAR Insights and synthetic approaches / Kristin Leyerer ; Betreuer: Christian Ducho." Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2018. http://nbn-resolving.de/urn:nbn:de:bsz:291--ds-280041.

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6

Guo, Jincan. "Biosyntheis of Blasticidin S : pathway and enzymes for the nucleoside formation and blastidic acid assembly." Thesis, 1992. http://hdl.handle.net/1957/36622.

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Books on the topic "Nucleoside antibiotic synthesis"

1

Guo, Jincan. Biosyntheis of Blasticidin S: Pathway and enzymes for the nucleoside formation and blastidic acid assembly. 1992.

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2

Modified Nucleosides: In Biochemistry, Biotechnology and Medicine. Wiley-VCH, 2008.

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3

Piet, Herdewijn, ed. Modified nucleosides: In biochemistry, biotechnology, and medicine. Weinheim: Wiley-VCH, 2008.

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4

Herdewijn, Piet. Modified Nucleosides: In Biochemistry, Biotechnology and Medicine. Wiley & Sons, Incorporated, John, 2008.

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5

Herdewijn, Piet. Modified Nucleosides: In Biochemistry, Biotechnology and Medicine. Wiley & Sons, Limited, John, 2008.

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Book chapters on the topic "Nucleoside antibiotic synthesis"

1

Yang, Zhen-Jun, Maria-Grazia Concilio, Vasudevan Ramesh, and Li-He Zhang. "Synthesis and Evaluation of Novel Neamine–Nucleoside Conjugates as Potential Antibiotic Targets for Escherichia coli 16S Ribosomal RNA." In Epitranscriptomics, 151–63. New York, NY: Springer New York, 2018. http://dx.doi.org/10.1007/978-1-4939-8808-2_11.

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2

Datta, Apurba. "Synthetic Studies on Antifungal Peptidyl Nucleoside Antibiotics." In Chemical Synthesis of Nucleoside Analogues, 819–46. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2013. http://dx.doi.org/10.1002/9781118498088.ch18.

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3

De las Heras, Federico G., María José Camarasa, and José Fiandor. "Nucleosides: Potential Drugs for AIDS Therapy." In Recent Progress in the Chemical Synthesis of Antibiotics, 321–63. Berlin, Heidelberg: Springer Berlin Heidelberg, 1990. http://dx.doi.org/10.1007/978-3-642-75617-7_9.

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4

Sun, Dianqing, and Richard Lee. "High-Throughput Solid-Phase Synthesis of Nucleoside- Based Libraries in the Search for New Antibiotics." In High-Throughput Lead Optimization in Drug Discovery, 215–38. CRC Press, 2008. http://dx.doi.org/10.1201/9781420006964.ch9.

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5

"High-Throughput Solid-Phase Synthesis of Nucleoside-Based Libraries in the Search for New Antibiotics." In High-Throughput Lead Optimization in Drug Discovery, 225–48. CRC Press, 2008. http://dx.doi.org/10.1201/9781420006964-12.

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