Dissertations / Theses on the topic 'Nuclear role'
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Di, Vona Chiara 1981. "Nuclear DYRK1A :new insights into its role within the nucleus." Doctoral thesis, Universitat Pompeu Fabra, 2013. http://hdl.handle.net/10803/283483.
Resultados recientes han puesto de manifiesto que la regulación de la expresión génica por proteína quinasas va mas allá de su modulación de la actividad de factores de transcripción, ya que tanto histonas como remodeladores de cromatina o componentes de la maquinaria basal de transcripción puedes ser sustratos de fosforilaciones directamente en regiones genómicas reguladoras. La proteína quinasa DYRK1A (dual-specificity tyrosine-regulated kinase) está presente tanto en el núcleo como en el citoplasma de células de mamífero, si bien la mayoría de sus actividades nucleares pueden ser explicadas por fosforilaciones que ocurren en el citosol, lo que ha planteado dudas sobre si esta quinasa posee funciones específicamente nucleares. En este trabajo, se ha definido el primer "interactoma" nuclear de DYRK1A mediante una aproximación proteómica no sesgada, que ha permitido mostrar que DYRK1A interacciona con componentes de la maquinaria basal de transcripción así como con complejos implicados en el procesamiento del pre-mRNA. Los resultados también han puesto de manifiesto un nuevo papel de DYRK1A como regulador de la transcripción de un grupo específico de genes relacionados con la traducción de proteínas. Análisis a nivel genómico de la presencia de DYRK1A en cromatina muestra que la quinasa es reclutada a regiones proximales de promotores dependientes de la RNA polimerasa II, mediante una secuencia palindrómica altamente conservada, así como a genes dependientes de la RNA polimerasa III. La inducción de la expresión de un grupo de estos genes diana (tanto codificantes como tRNAs) en respuesta a factores de crecimiento depende de DYRK1A. Además, la reducción en los niveles de DYRK1A provoca una reducción en el tamaño de las células. Los resultados permiten proponer un modelo por el que DYRK1A podría regular directamente la expresión de genes diana mediante la fosforilación, en regiones reguladoras promotoras, de diferentes componentes de la maquinaria basal de la transcripción y/o de los complejos proteicos implicados en el procesamiento del mRNA.
BERTORA, STEFANIA. "ROLE OF NUCLEAR ENVELOPE PROTEIN MAN1 IN NUCLEAR ORGANISATION AND MAINTENANCE OF GENOME STABILITY." Doctoral thesis, Università degli Studi di Milano, 2018. http://hdl.handle.net/2434/554706.
Reed, Alexander Ryan. "The role of technology denial in nuclear nonproliferation." Connect to Electronic Thesis (CONTENTdm), 2010. http://worldcat.org/oclc/643295978/viewonline.
Meaburn, Karen Jane. "The role of nuclear architecture in genomic stability." Thesis, Brunel University, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.422417.
Nofsinger, Russell R. "Role of corepressor SMRT in nuclear receptor biology /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2004. http://wwwlib.umi.com/cr/ucsd/fullcit?p3148259.
Katukhov, Alexey V. "The role of uranium enrichment in nuclear proliferation and potential implications for Iran's nuclear program." Connect to Electronic Thesis (CONTENTdm), 2010. http://worldcat.org/oclc/648979958/viewonline.
Walther, Tobias. "The role of Peripheral Nuclear Pore Complex (NPC) structures in nuclear transport and NPC architecture." Diss., lmu, 2002. http://nbn-resolving.de/urn:nbn:de:bvb:19-4945.
Knöpfel, Sascha [Verfasser], and Michael [Akademischer Betreuer] Brzoska. "The Roles of Non-Nuclear-Weapon States in Advancing Nuclear Disarmament from 2007 to 2013 : Ideal Type Role Concepts as well as Germany’s Role Conception and Role Performance / Sascha Knöpfel ; Betreuer: Michael Brzoska." Hamburg : Staats- und Universitätsbibliothek Hamburg, 2019. http://d-nb.info/1201821231/34.
Dumas, Gaelle. "THE ROLE OF HOST GALAXY KINEMATICS ON NUCLEAR ACTIVITY." Phd thesis, Ecole normale supérieure de lyon - ENS LYON, 2008. http://tel.archives-ouvertes.fr/tel-00350474.
permet de sonder à differentes échelles spatiales les perturbations liées à l'alimentation du noyau actif.
Du, Tung-Gia. "Role of nuclear RNP assembly in cytoplasmic mRNA localization." Diss., lmu, 2007. http://nbn-resolving.de/urn:nbn:de:bvb:19-76883.
O'Carroll, Simon J. (Simon Joseph). "The role of nuclear lipid signalling in adipocyte differentiation." Thesis, University of Auckland, 2005. http://hdl.handle.net/2292/3189.
Whole document restricted, but available by request, use the feedback form to request access.
Loinder, Kristina. "Nuclear receptor corepressor N-CoR : role in transcriptional repression /." Linköping : Univ, 2004. http://www.bibl.liu.se/liupubl/disp/disp2004/med869s.pdf.
Bayliss, R. W. R. "The role of FxFG-repeat nucleoporins in nuclear trafficking." Thesis, University of Cambridge, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.596489.
Roy, Nina [Verfasser]. "Study on the role of nuclear Cofilin1 / Nina Roy." Bonn : Universitäts- und Landesbibliothek Bonn, 2016. http://d-nb.info/1149154551/34.
Houalla, Rym. "The role of yeast Rrp6p in nuclear RNA turnover." Thesis, University of Edinburgh, 2003. http://hdl.handle.net/1842/14107.
Dumas, Gaëlle. "The role of host galaxy kinematics in nuclear activity." Thesis, Liverpool John Moores University, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.494047.
Kituyi, Sarah Naulikha. "The role of HOP in Emerin-mediated nuclear structure." Thesis, Rhodes University, 2017. http://hdl.handle.net/10962/59230.
Wang, Weizhong. "Nuclear galectins and their role in pre-mRNA splicing." Diss., Connect to online resource - MSU authorized users, 2006.
Title from PDF t.p. (viewed on Nov. 20, 2008) Includes bibliographical references. Also issued in print.
Byrd, Ronald Keith. "The role of the gypsy insulator in nuclear organization." Available to US Hopkins community, 2002. http://wwwlib.umi.com/dissertations/dlnow/3068125.
Nikitin, Artemii. "Role of nuclear receptor RORα in regulatory T cells." Thesis, Université de Lille (2018-2021), 2019. http://www.theses.fr/2019LILUS073.
Transcription factors of the nuclear receptor superfamily have a vast influence on development and function ofregulatory T cell (TREG) cells. TREG cells are suppressive immune cells of adaptive immune system. Their mainfunctions are control of inflammatory response mounted by other immune cells and maintenance of localtissue homeostasis. As TREG act at various sites of the body and both in homeostatic and inflammatory state,they need to adequately respond to local tissue-specific cues as well as adapt to aggressive immuneenvironments while preserving their long-lasting tolerogenic properties. This is achieved by weaving complextranscriptional networks, converging at transcription factors with various coordination functions, the mainbeing forkhead box P3 (FOXP3). During last few years, many studies focused on TREG cells found innon-lymphoid tissue (NLT). These populations of TREG are examined in the contexts of homeostasis and manyinflammatory diseases, and tissue- or function-specific transcription factor (TF) were assigned to some ofthem as regulators of development, activation, proliferation, stability, migration and suppressive functions.Retinoic acid receptor-related orphan receptor alpha (RORa) is a nuclear receptor, which controls cerebellumdevelopment, liver and whole-body metabolism and differentiation of T-helper (TH)17, type 2 innate lymphoidcells (ILC2) and type 3 innate lymphoid cells (ILC3). RORa is highly expressed in NLT TREG, includingpopulations in visceral adipose tissue (VAT), intestine and skin, and gets more and more mentions in thearticles dedicated to TREG in NLT. These RORa-expressing populations of TREG were all shown to be involvedin various pathologies. However, RORa role in TREG was directly addressed only once in a recent study. It’sactive involvement in various processes, high expression in NLT TREG and lack of knowledge make RORa anattractive target for investigation, to deepen current view of homeostasis control by TREG and thus betterunderstand mechanisms of development of associated diseases. To attain these objectives, a mouse strain withTREG-specific RORa deficiency was generated. Our central hypothesis is that RORa controls development orfunction of TREG cells in homeostasis of NLT and potentially in inflammatory diseases. For studying a role ofRORa in NLT TREG during control of tissue homeostasis, in particular, VAT TREG, we have charachterizedphenotype of untreated RORaFoxp3/Foxp3 mice and challenged mice with a model of diet-induced obesity(DIO). In both cases we have found an important role of TREG-expressed RORa. To further investigate a roleof RORa in TREG during pathologies and it’s contribution to various types of immune response we have testedan involvement of RORa in TREG in the model of allergic pathology, namely house dust mite (HDM)-inducedallergic airway inflammation (AAI) model.To elucidate molecular mechanisms of RORa action in TREG cells, we have performed gene expression profilingof TREG cells from examined tissues and conditions in vivo, as well as in vitro. We also have studied a role ofRORa in epigenetic landscape of TREG cells in vitro by probing histone acetylation marks genome wide. As aresult of this study, we have gained a broader understanding of TREG control by nuclear receptors and TF ingeneral in homeostatic conditions and during inflammation. Nuclear receptors proved to be useful targets fortherapeutic agents thanks to their versatile functions inside the cell and to ligand-dependency. Given thecrucial importance of TREG cells in organismal homeostasis and their involvement in numerous pathologies,targeting particular cues inside these cells may be a powerful tool in new treatment strategies. Results of ourstudy might serve as a basis for development of novel pharmaceutical agents targeting RORa
Thompson, D. E. "The ecology of steroid nuclear dehydrogenating clostridia in the gut." Thesis, Open University, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.380701.
Amira, Manelle. "Investigating the role of nuclear myosin I in the low serum induced repositioning of chromosome 10 in interphase nuclei." Thesis, Brunel University, 2010. http://bura.brunel.ac.uk/handle/2438/4621.
Woo, Dong Kyun. "Mitochondrial-nuclear communication: A role of the mitochondrial genome in nuclear gene expression and aging in yeast." Diss., Connect to online resource, 2006. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3207759.
Kelly, Richard David William. "Developmant of bovine nuclear transfer produced embryos : nuclear lamins expression and the role of heat shock proteins." Thesis, University of Nottingham, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.478928.
Luck, Stanley David. "The role of magnetic field gradients in nuclear magnetic resonance." Thesis, University of British Columbia, 1986. http://hdl.handle.net/2429/27541.
Science, Faculty of
Chemistry, Department of
Graduate
Gao, Kai. "The role of nuclear factor kappaB subunit p50 melanoma pathogenesis." Thesis, University of British Columbia, 2007. http://hdl.handle.net/2429/31757.
Medicine, Faculty of
Medicine, Department of
Experimental Medicine, Division of
Graduate
Debevec, Darja. "The role of the nuclear receptor corepressor RIP140 in adipocytes." Thesis, Imperial College London, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.435008.
Rampersaud, Navita. "Role of the nuclear substructure in immediate-early gene induction." Thesis, University of Oxford, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.400439.
Garnaas, Maija Kristine. "The Role of Nuclear Receptor Signaling in Vertebrate Liver Development." Thesis, Harvard University, 2014. http://dissertations.umi.com/gsas.harvard:11344.
Coleman, Stacey J. "The role of nuclear FGFR1 and FGF2 in pancreatic cancer." Thesis, Queen Mary, University of London, 2013. http://qmro.qmul.ac.uk/xmlui/handle/123456789/8403.
Monaghan, Richard. "A novel nuclear role for the mitochondrial hydroxylase Clk-1." Thesis, University of Manchester, 2012. https://www.research.manchester.ac.uk/portal/en/theses/a-novel-nuclear-role-for-the-mitochondrial-hydroxylase-clk1(8de582a1-bfe3-4421-bfbf-75f9229a13b1).html.
Drożdż, Marek Mateusz. "The role of the nuclear envelope in regulation of ageing." Thesis, University of Oxford, 2015. https://ora.ox.ac.uk/objects/uuid:0766d5da-e570-43ef-9a0c-5f39a3a15e30.
Somers, Sarin J. "Role of nuclear factors kappa-B in TNFα-induced cytoprotection." Master's thesis, University of Cape Town, 2006. http://hdl.handle.net/11427/3466.
Ta, Michelle Hieu Thao. "Role Of Nuclear Factor Kappa B In Polycystic Kidney Disease." Thesis, The University of Sydney, 2016. http://hdl.handle.net/2123/15821.
Cleasby, Alexa. "Investigating the role of a novel nuclear ESCRT-III assembly." Thesis, University of Sheffield, 2014. http://etheses.whiterose.ac.uk/5588/.
何潔雲 and Kit-wan Ho. "The role of the Legislative Council in the Daya Bay controversy." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1988. http://hub.hku.hk/bib/B31975367.
Smith, Robert A. "The Role of the Steroid Nuclear Receptor Genes in Breast Cancer." Thesis, Griffith University, 2006. http://hdl.handle.net/10072/365401.
Thesis (PhD Doctorate)
Doctor of Philosophy (PhD)
School of Medical Science
Full Text
Pinto, Belinda Sophia. "Understanding the role of LEM domain proteins in Drosophila development." Diss., University of Iowa, 2009. https://ir.uiowa.edu/etd/421.
Portier, Nathan Charles. "A role for aurora A kinase in timely nuclear envelope breakdown." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2007. http://wwwlib.umi.com/cr/ucsd/fullcit?p3270970.
Title from first page of PDF file (viewed April 9, 2008). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references.
Minoda, Akiko. "The role of fission yeast nuclear actin-related protein in mitosis." Thesis, University College London (University of London), 2005. http://discovery.ucl.ac.uk/1444847/.
Embleton, Joanne Jane. "A study of nuclear FGF-3 and its potential biological role." Thesis, King's College London (University of London), 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.392429.
Krelekrele, Thembela. "The role of Highly Enriched Uranium in South Africa’s nuclear diplomacy." University of the Western Cape, 2021. http://hdl.handle.net/11394/8306.
Highly enriched uranium (HEU) is one of the most dangerous materials in the world, because it is a key ingredient in making a nuclear bomb. If a terrorist organisation can get HEU, it would be close to making a nuclear bomb. After South Africa disarmed its nuclear weapons, it kept HEU that was extracted from the nuclear bombs. The US tried to persuade South Africa to blend down its HEU into low enriched uranium (LEU) or give it up for safekeeping. However, South Africa refused to give it up. After a breach at Pelindaba, a national key point facility where South Africa stores its HEU, the US intensified its efforts to pressure South Africa to give its HEU up. It even promised incentives to South Africa should they agree to give it up, but South Africa refused. The US used the nuclear terrorism narrative to justify its initiative to eliminate vulnerable materials in the world. However, South Africa is yet to be swayed. This is odd since South Africa's refusal can negatively affect its credentials as a nuclear nonproliferation and disarmament champion and its image as a norm entrepreneur. The objective of the study was to understand the role played by HEU in South Africa's nuclear diplomacy. It was to explore HEU as a factor in the state's nuclear diplomacy and to understand the power of having HEU in nuclear negotiations, as well as what SA intends to do with its HEU. The study is framed theoretically by drawing on foreign policy theory, namely middle-power theory, and revisionism. It juxtaposed middle power, reformist, and revisionist positions with status quo foreign policy to analyse the role of HEU in South Africa's nuclear diplomacy. As a middle power with a moral high ground, South Africa hoped that it can affect change in the nuclear regime. However, when this did not occur its foreign policy shifted to a revisionist character that is discontent with the status quo in the nuclear regime. SA is dissatisfied with the current nuclear order and wants it revised towards liberal values such as equality and nondiscrimination. It views the current nuclear order as nuclear apartheid.
Muangmoonchai, Roongsiri. "Regulation of rat CYP2B1 gene expression : the role of nuclear receptors." Thesis, University College London (University of London), 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.392665.
Parker, Krystal 'Detweiler'. "The role of cerebellar nuclear GABAergic neurotransmission in eyeblink motor control." [Ames, Iowa : Iowa State University], 2009. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3355523.
Saleem, Zmkan Ali. "Determinants of Iran's nuclear ambitions : the role of the ethnic factor." Thesis, University of Leeds, 2014. http://etheses.whiterose.ac.uk/8776/.
Nichols, Brandt Alan. "The Role of Nuclear BMP2 in the Cell Cycle and Tumorigenesis." BYU ScholarsArchive, 2013. https://scholarsarchive.byu.edu/etd/4167.
Hsü, Ling-chih. "The role of the nuclear factor in the Sino-Soviet split." Thesis, Canberra, ACT : The Australian National University, 1989. http://hdl.handle.net/1885/111994.
Dion, Maxime. "Thermal photons and their role in probing the dynamics of heavy ion collisions." Thesis, McGill University, 2011. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=104864.
Cet ouvrage concerne la production de photons thermaux provenant du Plasma Quarks Gluons (PQG) et du gaz hadronique (GH) dans les collisions d'ions lourds. Nous utilisons un modèle hydrodynamique 3D + 1 (MUSIC) pour décrire le système après la thermalisation d'une collision Au+Au, avec lequel nous calculons la production totale de photons thermaux. Nous utilisons des modèles effectifs pour les interactions mésoniques dans le GH et dans le PQG. Nous comparons la production totale et l'écoulement elliptique des photons pour les deux sources et regardons comment la centralité et les équations d'état influencent les observables photoniques.Nous utilisons un modèle hydrodynamique idéal (non dissipatif), mais aussi un modèle incluant la viscosité. Nous regardons comment les propriétés hydrodynamiques (température, écoulement) sont modifiées par la viscosité de cisaillement et son effet sur la production de photons. De plus, la viscosité a aussi pour effet d'apporter une correction aux fonctions de distribution des quarks et des mesons. Dans notre approche, nous calculons numériquement les intégrales nécessaires pour les corrections visqueuses et tabulons les résultats en fonction de la température et de l'énergie du photon et interpolons entre ces valeurs. Nous examinons comment cela affecte la production totale de photons ainsi que l'écoulement elliptique. Nous regardons aussi l'effet des conditions initiales aléatoires.Nos calculs montrent que la viscosité a un effet significatif sur la production de photons, et surtout sur l'écoulement elliptique de ceux-ci. Les conditions initiales aléatoires ont aussi un effet très appréciable sur la production totale de photons. Pour tous les éléments mentionnés ci-haut, nos calculs sont restreints à des énergies du photon de 0.2 GeV à 4 GeV, qui correspond à la plage d'énergie pour laquelle les photons thermaux contribuent de façon significative à la production complète de photons (incluant tous les autres procédés pertinents). Nous montrons que les photons font d'excellentes sondes pour les collisions d'ions lourds car ils sont très sensibles aux concepts théoriques importants dont notre modèle dépend.
Mossaid, Ikram. "The nuclear pore protein Nup153: Dissecting its role in nuclear envelope and nuclear pore complex architecture and its interaction with the spindle assembly checkpoint protein Mad1." Doctoral thesis, Universite Libre de Bruxelles, 2016. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/234375.
Les pores nucléaires sont des structures enchâssées dans l’enveloppe nucléaire et composées de protéines appelées les nucléoporines. Ces pores nucléaires contrôlent le trafic bidirectionnel des protéines et des ARNs entre le noyau et le cytoplasme dans les cellules eucaryotes tandis que les nucléoporines individuelles sont également impliquées dans d’autres processus cellulaires tels que la division cellulaire, l’assemblage des kinétochores, l’expression génétique et la migration cellulaire. Un exemple primordial de la versatilité fonctionnelle des nucléoporines peut être observé à travers Nup153. Depuis sa découverte, Nup153 est connue pour être un élément clé dans le transport nucléo-cytoplasmique, mais il a également été démontré qu’elle participait directement ou indirectement à l’expression génétique et au contrôle du cycle cellulaire. Dans ce contexte, nous avons montrés précédemment que des niveaux altérés de Nup153 menaient à des anomalies mitotiques, particulièrement en cytokinèse et dans le point de contrôle de l’assemblage du fuseau mitotique (SAC). Le SAC assure la ségrégation correcte du matériel génétique entre les cellules filles. Il a été montré que Nup153 interagit avec la protéine du SAC Mad1. Dans cette étude, nous avons utilisé une technique d’imagerie de haute résolution, « in situ proximity ligation assay » pour disséquer davantage l’interaction entre Nup153 et Mad1 dans les cellules humaines. Nous avons montré que ces deux protéines interagissent exclusivement au niveau de l’enveloppe nucléaire, depuis les dernières phases de la mitose jusqu’à la prophase. Par des expériences d’interaction in vitro, nous avons également identifiés sur Mad1 deux sites de liaison indépendants pour Nup153. Nous avons également fourni des indications que Nup153 interagit aussi avec une forme SUMOylée de Mad1. La déplétion de Mad1 menait à un recrutement tardif de Nup153 au niveau de l’enveloppe nucléaire en cours de reformation en anaphase dans les cellules vivantes et à des altérations de l’architecture de l’enveloppe nucléaire, caractérisées par un changement de la courbure membranaire au niveau de l’interface pore nucléaire-enveloppe nucléaire. Suite à cela, une expansion de l’espace entre les membranes nucléaires internes et externes a été observée par microscopie électronique. Ceci suggère une implication de Mad1 dans un mécanisme lié à la stabilité de l’enveloppe nucléaire indépendant du SAC. La déplétion de Mad1 résultait également en une redistribution du RE et des mitochondries à travers la cellule. La déplétion de Nup153 coïncidait avec des anomalies similaires au niveau de l’enveloppe nucléaire et des organelles. De plus, la déplétion de Nup153 affectait partiellement la localisation des nucléoporines cytoplasmiques, contrairement à la déplétion de Mad1. Ensemble, nos résultats suggèrent que Nup153 est essentielle pour l’intégrité des pores nucléaires et de l’enveloppe nucléaire. Nup153 semble avoir deux rôles, un au niveau de la formation de l’enveloppe nucléaire en fin de mitose, en complexe avec Mad1 et un autre rôle au niveau de l’assemblage des pores nucléaires. Le complexe Nup153-Mad1 a une fonction indépendante du SAC, mais importante pour l’établissement d’une enveloppe nucléaire intacte.
Doctorat en Sciences
info:eu-repo/semantics/nonPublished
Van, Zyl Johannes Jacobus. "The role of a direct knock-out mechanism in the inclusive (p, \03B1) reaction /." Link to the online version, 2008. http://hdl.handle.net/10019/797.