Relevant bibliographies by topics / NTCP

Academic literature on the topic 'NTCP'

Author: Grafiati
Published: 4 June 2021
Last updated: 31 January 2023

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Contents

Consult the lists of relevant articles, books, theses, conference reports, and other scholarly sources on the topic 'NTCP.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Journal articles on the topic "NTCP"

1

Bai, Han, Li Wang, Wenhui Li, Xuhong Liu, Yaoxiong Xia, and Li Chang. "Test the Effectiveness of Quantitative Linear-Quadratic-Based (qLQB) Model on Evaluating Irradiation-Induced Liver Injury (ILI) Against Normal Tissue Complication Probability (NTCP)." Dose-Response 18, no. 3 (July 1, 2020): 155932582096172. http://dx.doi.org/10.1177/1559325820961721.

Full text
Abstract:
Objectives: To test the effectiveness of quantitative linear-quadratic-based (qLQB) model on evaluating irradiation-induced liver injury (ILI) and establish the relation between the damaged ratio/percent (DRP) in qLQB model and normal tissue complication probility (NTCP). Materials and Methods: We established the qLQB model to calculate the ratio/percent (RP) between damaged cell/functional subunit (FSU) and entire cell/FSU of liver for radiation dose response, tested the qLQB against the Lyman-Kutcher-Burman (LKB) model, and established relation between the RP and NTCP through analyzing the dose of 32 patients with cancer of abdominal cavity who were treated with radiation therapy at our department. Based on varied α/β and varied parameters for NTCP, we put the calculated results into varied arrays for the next analysis. We named the 2 groups of RPs: RP1 (α/β = 3.0, α = 0.03) and RP2 (α/β = 8.0, α = 0.26), and named the 2 groups of NTCPs: NTCP1 (n = 0.32, m = 0.15, TD50(1) = 4000 cGy) and NTCP2 (n = 1.10, m = 0.28, TD50(1) = 4050 cGy). Results: Spearman correlation analysis was used to analyze the correlations among the groups, the results were as follows: RP1 vs NTCP1, rs = 0.83827, p < 0.0001; RP1 vs NTCP2, rs = 0.83827, p < 0.0001; RP2 vs NTCP2, rs = 0.79289, p < 0.0001; and RP2 vs NTCP1, rs = 0.79289, p < 0.0001. Conclusions: There is a significant correlation between RP value and NTCP for evaluating ILI, and there is no difference between qLQB model and LKB model on evaluating ILI.
APA, Harvard, Vancouver, ISO, and other styles
2

Hanada, Takashi, Yutaka Shiraishi, Toshio Ohashi, Junichi Fukada, Tomoki Tanaka, Atsunori Yorozu, and Naoyuki Shigematsu. "Variations in Rectal Volumes and Dosimetry Values Including NTCP due to Interfractional Variability When Administering 2D-Based IG-IMRT for Prostate Cancer." Journal of Radiotherapy 2014 (July 15, 2014): 1–7. http://dx.doi.org/10.1155/2014/298904.

Full text
Abstract:
We estimated variations in rectal volumes and dosimetry values including NTCP with interfractional motion during prostate IG-IMRT. Rectal volumes, DVH parameters, and NTCPs of 20 patients were analyzed. For this patient population, the median (range) volume on the initial plan for the rectum was 45.6 cc (31.3–82.0), showing on-treatment spread around the initial prediction based on the initial plan. DVH parameters of on-treatment CBCT analyses showed systematic regularity shift from the prediction based on the initial plan. Using the Lyman-Kutcher-Burman model, NTCPs of predicted late rectal bleeding toxicity of rectal grade ≥ 2 (RTOG) and the QUANTEC update rectal toxicity for the prediction based on the initial plan were 0.09% (0.02–0.24) and 0.02% (0.00–0.07), respectively, with NTCPs from on-treatment CBCT analyses being 0.35% (0.01–6.16) and 0.12% (0.00–4.11), respectively. Using the relative seriality model, for grade ≥ 2 bleeding rectal toxicity, NTCP of the prediction based on the initial plan was 0.64% (0.15–1.22) versus 1.48% (0.18–7.66) for on-treatment CBCT analysis. Interfraction variations in rectal volumes occur in all patients due to physiological changes. Thus, rectal assessment during 2D-based IG-IMRT using NTCP models has the potential to provide useful and practical dosimetric verification.
APA, Harvard, Vancouver, ISO, and other styles
3

Chamunyonga, Crispen. "The impact of inter-fraction set-up errors on the probability of pulmonary and cardiac complication in left-sided breast cancer patients." Journal of Radiotherapy in Practice 13, no. 4 (February 17, 2014): 393–402. http://dx.doi.org/10.1017/s1460396914000065.

Full text
Abstract:
AbstractPurposeThis study evaluated the impact of patient set-up errors on the probability of pulmonary and cardiac complications in the irradiation of left-sided breast cancer.Methods and materialsUsing the CMS XiO Version 4·6 radiotherapy planning system's normal tissue complication probability (NTCP) algorithm and the Lyman–Kutcher–Burman model, we calculated the dose–volume histograms (DVH) indices for the ipsilateral lung and heart and the resultant NTCP for radiation-induced pneumonitis and excess cardiac mortality in 12 left-sided breast cancer patients.ResultsIsocentric shifts in the posterior direction had the greatest effect on the lung V20, heart V25, and mean and maximum doses to the lung and the heart. DVH results show that the ipsilateral lung V20 tolerance was exceeded in 58% of the patients after 1 cm posterior shifts. Similarly, the heart V25 tolerance was exceeded after 1 cm antero-posterior and left–right isocentric shifts in 70% of the patients. The baseline NTCPs for radiation-induced pneumonitis ranged from 0·73% to 3·4%, with a mean value of 1·7%. The maximum reported NTCP for radiation-induced pneumonitis was 5·8% (mean 2·6%) after 1 cm posterior isocentric shift. The NTCP for excess cardiac mortality were 0% in 100% of the patients (n = 12) before and after set-up error simulations.ConclusionsSet-up errors in left-sided breast cancer patients have a statistically significant impact on the Lung NTCPs and DVH indices. However, with a central lung distance of 3 cm or less (CLD < 3 cm), and a maximum heart distance of 1·5 cm or less (MHD < 1·5 cm), the treatment plans could tolerate set-up errors of up to 1 cm without any change in the NTCP to the heart.
APA, Harvard, Vancouver, ISO, and other styles
4

Hytönen, Roni, Reynald Vanderstraeten, Max Dahele, and Wilko F. A. R. Verbakel. "Influence of Beam Angle on Normal Tissue Complication Probability of Knowledge-Based Head and Neck Cancer Proton Planning." Cancers 14, no. 12 (June 9, 2022): 2849. http://dx.doi.org/10.3390/cancers14122849.

Full text
Abstract:
Knowledge-based planning solutions have brought significant improvements in treatment planning. However, the performance of a proton-specific knowledge-based planning model in creating knowledge-based plans (KBPs) with beam angles differing from those used to train the model remains unexplored. We used a previously validated RapidPlanPT model and scripting to create nine KBPs, one with default and eight with altered beam angles, for 10 recent oropharynx cancer patients. The altered-angle plans were compared against the default-angle ones in terms of grade 2 dysphagia and xerostomia normal tissue complication probability (NTCP), mean doses of several organs at risk, and dose homogeneity index (HI). As KBP could be suboptimal, a proof of principle automatic iterative optimizer (AIO) was added with the aim of reducing the plan NTCP. There were no statistically significant differences in NTCP or HI between default- and altered-angle KBPs, and the altered-angle plans showed a <1% reduction in NTCP. AIO was able to reduce the sum of grade 2 NTCPs in 66/90 cases with mean a reduction of 3.5 ± 1.8%. While the altered-angle plans saw greater benefit from AIO, both default- and altered-angle plans could be improved, indicating that the KBP model alone was not completely optimal to achieve the lowest NTCP. Overall, the data showed that the model was robust to the various beam arrangements within the range described in this analysis.
APA, Harvard, Vancouver, ISO, and other styles
5

Jung, Diana, Bruno Hagenbuch, Michael Fried, Peter J. Meier, and Gerd A. Kullak-Ublick. "Role of liver-enriched transcription factors and nuclear receptors in regulating the human, mouse, and rat NTCP gene." American Journal of Physiology-Gastrointestinal and Liver Physiology 286, no. 5 (May 2004): G752—G761. http://dx.doi.org/10.1152/ajpgi.00456.2003.

Full text
Abstract:
Hepatic uptake of bile acids is mediated by the Na+-taurocholate cotransporting polypeptide (NTCP; SLC10A1) of the basolateral hepatocyte membrane. Several cis-acting elements in the rat Ntcp gene promoter have been characterized. However, little is known about the mechanisms that control the expression of the human or mouse NTCP/Ntcp. We, therefore, compared the transcriptional regulation of the human and mouse NTCP/Ntcp gene with that of the rat. By computer alignment, a sequence in the 5′-regulatory region that is conserved between species was identified near the transcription start site. Huh7 cells were transfected with luciferase constructs containing the conserved region from each species. The hepatocyte nuclear factors (HNF)1α and -4α and the retinoid X receptor/retinoic acid receptor dimer (RXRα/RARα) bound and transactivated the rat but not the human or mouse NTCP/Ntcp promoters. In contrast, activation by the CCAAT/enhancer binding protein-β was specific for human and mouse NTCP/Ntcp. The only consensus motif present in all three species was HNF3β. HNF3β formed a specific DNA-protein complex in electrophoretic mobility shift assays and inhibited NTCP/Ntcp promoter activity in cotransfection assays. Finally, a minor repressive effect of bile acids was only found for rat Ntcp. The transcriptional repressor small heterodimer partner (SHP) did not affect NTCP/Ntcp promoter activity. We conclude that 1) the transcriptional regulation of the conserved NTCP/Ntcp 5′-regulatory region differs considerably among human, mouse, and rat; and 2) the conserved NTCP/Ntcp regulatory region is not directly regulated by SHP. Bile acids may regulate NTCP/Ntcp indirectly by modulating the capacity of nuclear factors to activate gene expression.
APA, Harvard, Vancouver, ISO, and other styles
6

Bijsmans, Ingrid T. G. W., Rianne A. M. Bouwmeester, Joachim Geyer, Klaas Nico Faber, and Stan F. J. van de Graaf. "Homo- and hetero-dimeric architecture of the human liver Na+-dependent taurocholate co-transporting protein." Biochemical Journal 441, no. 3 (January 16, 2012): 1007–16. http://dx.doi.org/10.1042/bj20111234.

Full text
Abstract:
The NTCP (Na+–taurocholate co-transporting protein)/SLC10A [solute carrier family 10 (Na+/bile acid co-transporter family)] 1 is tightly controlled to ensure hepatic bile salt uptake while preventing toxic bile salt accumulation. Many transport proteins require oligomerization for their activity and regulation. This is not yet established for bile salt transporters. The present study was conducted to elucidate the oligomeric state of NTCP. Chemical cross-linking revealed the presence of NTCP dimers in rat liver membranes and U2OS cells stably expressing NTCP. Co-immunoprecipitation of tagged NTCP proteins revealed a physical interaction between subunits. The C-terminus of NTCP was not required for subunit interaction, but was essential for exit from the ER (endoplasmic reticulum). NTCP without its C-terminus (NTCP Y307X) retained full-length wtNTCP (wild-type NTCP) in the ER in a dominant fashion, suggesting that dimerization occurs early in the secretory pathway. FRET (fluorescence resonance energy transfer) using fluorescently labelled subunits further demonstrated that dimerization persists at the plasma membrane. NTCP belongs to the SLC10A protein family which consists of seven members. NTCP co-localized in U2OS cells with SLC10A4 and SLC10A6, but not with SLC10A3, SLC10A5 or SLC10A7. SLC10A4 and SLC10A6 co-immunoprecipitated with NTCP, demonstrating that heteromeric complexes can be formed between SLC10A family members in vitro. Expression of SLC10A4 and NTCP Y307X resulted in a reduction of NTCP abundance at the plasma membrane and NTCP-mediated taurocholate uptake, whereas expression of SLC10A6 or NTCP E257N, an inactive mutant, did not affect NTCP function. In conclusion, NTCP adopts a dimeric structure in which individual subunits are functional. Bile salt uptake is influenced by heterodimerization when this impairs NTCP plasma membrane trafficking.
APA, Harvard, Vancouver, ISO, and other styles
7

Simon, Francis R., John Fortune, Mieko Iwahashi, Ishtiaq Qadri, and Eileen Sutherland. "Multihormonal regulation of hepatic sinusoidalNtcpgene expression." American Journal of Physiology-Gastrointestinal and Liver Physiology 287, no. 4 (October 2004): G782—G794. http://dx.doi.org/10.1152/ajpgi.00379.2003.

Full text
Abstract:
Bile acids are efficiently removed from sinusoidal blood by a number of transporters including the Na+-taurocholate-cotransporting polypeptide (Ntcp). Na+-dependent bile salt uptake, as well as Ntcp, are expressed twofold higher in male compared with female rat livers. Also, estrogen administration to male rats decreases Ntcp expression. The aims of this study were to determine the hormonal mechanism(s) responsible for this sexually dimorphic expression of Ntcp. We examined castrated and hypophysectomized rats of both sexes. Sex steroid hormones, growth hormone, thyroid, and glucocorticoids were administered, and livers were examined for changes in Ntcp messenger RNA (mRNA). Ntcp mRNA and protein content were selectively increased in males. Estradiol selectively decreased Ntcp expression in males, whereas ovariectomy increased Ntcp in females, confirming the importance of estrogens in regulating Ntcp. Hypophysectomy decreased Ntcp mRNA levels in males and prevented estrogen administration from decreasing Ntcp, indicating the importance of pituitary hormones. Although constant infusion of growth hormone to intact males reduced Ntcp, its replacement alone after hypophysectomy did not restore the sex differences. In contrast, thyroid hormone and corticosterone increased Ntcp mRNA in hypophysectomized rats. Sex differences in Ntcp mRNA levels were produced only when the female pattern of growth hormone was administered to animals also receiving thyroid and corticosterone. Thyroid and dexamethasone also increased Ntcp mRNA in isolated rat hepatocytes, whereas growth hormone decreased Ntcp. These findings demonstrate the essential role that pituitary hormones play in the sexually dimorphic control of Ntcp expression in adult rat liver and in the mediation of estrogen effects.
APA, Harvard, Vancouver, ISO, and other styles
8

Bhardwaj, Ashok Kumar. "Tuberculosis control programme from NTCP to RNTCP to NTEP." Indian Journal of Community Health 32, no. 3 (September 30, 2020): 469–70. http://dx.doi.org/10.47203/ijch.2020.v32i03.001.

Full text
Abstract:
India, the highest TB burden country in the world, is having an estimated incidence of 26.9 lakh cases in 2019 (WHO). The year 2019 marks another milestone year for TB surveillance effort in India, with a record high notification of 24 lakhs cases; an increase of over 12% as compared to 2018. Of the 24 lakhs TB cases,(1) 21.6 lakhs were incident TB cases (New and Relapse/ Recurrent). This amount to an incident notification rate of approximately 159 cases/lakh against the estimated incidence rate of 199 cases/ lakh population; thus, closing the gap between the estimated and notified incident cases to just 40 Cases per lakh population, or an approximate of 5.4 lakh missing cases across India.
APA, Harvard, Vancouver, ISO, and other styles
9

Ramasamy, Umadevi, M. Sawkat Anwer, and Christopher M. Schonhoff. "Cysteine 96 of Ntcp is responsible for NO-mediated inhibition of taurocholate uptake." American Journal of Physiology-Gastrointestinal and Liver Physiology 305, no. 7 (October 1, 2013): G513—G519. http://dx.doi.org/10.1152/ajpgi.00089.2013.

Full text
Abstract:
The Na+taurocholate (TC) cotransporting polypeptide Ntcp/NTCP mediates TC uptake across the sinusoidal membrane of hepatocytes. Previously, we demonstrated that nitric oxide (NO) inhibits TC uptake through S-nitrosylation of a cysteine residue. Our current aim was to determine which of the eight cysteine residues of Ntcp is responsible for NO-mediated S-nitrosylation and inhibition of TC uptake. Thus, we tested the effect of NO on TC uptake in HuH-7 cells transiently transfected with cysteine-to-alanine mutant Ntcp constructs. Of the eight mutants tested, only C44A Ntcp displayed decreased total and plasma membrane (PM) levels that were also reflected in decreased TC uptake. C266A Ntcp showed a decrease in TC uptake that was not explained by a decrease in total expression or PM localization, indicating that C266 is required for optimal uptake. We speculated that NO would target C266 since a previous report had shown the thiol reactive compound [2-(trimethylammonium) ethyl] methanethiosulfonate bromide (MTSET) inhibits TC uptake by wild-type NTCP but not by C266A NTCP. We confirmed that MTSET targets C266 of Ntcp, but, surprisingly, we found that C266 was not responsible for NO-mediated inhibition of TC uptake. Instead, we found that C96 was targeted by NO since C96A Ntcp was insensitive to NO-mediated inhibition of TC uptake. We also found that wild-type but not C96A Ntcp is S-nitrosylated by NO, suggesting that C96 is important in regulating Ntcp function in response to elevated levels of NO.
APA, Harvard, Vancouver, ISO, and other styles
10

Zakrzewicz, Dariusz, Regina Leidolf, Sebastian Kunz, Simon Franz Müller, Anita Neubauer, Silke Leiting, Nora Goldmann, Felix Lehmann, Dieter Glebe, and Joachim Geyer. "Tyrosine 146 of the Human Na+/Taurocholate Cotransporting Polypeptide (NTCP) Is Essential for Its Hepatitis B Virus (HBV) Receptor Function and HBV Entry into Hepatocytes." Viruses 14, no. 6 (June 9, 2022): 1259. http://dx.doi.org/10.3390/v14061259.

Full text
Abstract:
Na+/taurocholate cotransporting polypeptide (NTCP, gene symbol SLC10A1) is a hepatic bile acid uptake carrier participating in the enterohepatic circulation of bile acids. Apart from its transporter function, NTCP acts as the high-affinity liver-specific receptor for the hepatitis B virus (HBV), which attaches via its preS1-peptide domain of the large surface protein to NTCP, subsequently leading to endocytosis of the virus/NTCP-receptor complex. Although the process of NTCP-dependent HBV infection of hepatocytes has received much attention over the last decade, the precise molecular sites of the virus/NTCP interaction have not been fully identified. Inspection of the primary protein sequence of human NTCP revealed 139YIYSRGIY146 as a highly conserved tyrosine-rich motif. To study the role of Y139, Y141 and Y146 amino acids in NTCP biology, the aforementioned residues were substituted with alanine, phenylalanine or glutamate (mimicking phosphorylation) using site-directed mutagenesis. Similar to wt NTCP, the Y139A, Y141A, Y146A, Y141F, Y146F, and Y146E mutants were expressed at the plasma membrane of HEK293 cells and exhibited intact bile acid transport function. Y146A, Y146E, and Y146F demonstrated transport kinetics comparable to wild-type NTCP with Km values of 57.3–112.4 µM and Vmax values of 6683–7579 pmol/mg protein/min. Only Y141E was transport deficient, most likely due to an intracellular accumulation of the mutant protein. Most importantly, Y146A and Y146E mutation completely abrogated binding of the viral preS1-peptide to NTCP, while the Y146F mutant of NTCP showed some residual binding competence for preS1. Consequently, the NTCP mutants Y146A and Y146E, when expressed in HepG2 hepatoma cells, showed complete loss of susceptibility for in vitro HBV infection. In conclusion, tyrosine 146, and to some extent tyrosine 141, both belonging to the tyrosine-rich motif 139YIYSRGIY146 of human NTCP, are newly identified amino acid residues that play an essential role in the interaction of HBV with its receptor NTCP and, thus, in the process of virus entry into hepatocytes.
APA, Harvard, Vancouver, ISO, and other styles
More sources

Dissertations / Theses on the topic "NTCP"

1

Zhu, Jian. "Modèles prédictifs de toxicité en radiothérapie par modulation d’intensité." Thesis, Rennes 1, 2013. http://www.theses.fr/2013REN1S017/document.

Full text
Abstract:
Ce travail de thèse est centré sur l'établissement de modèles prédictifs de toxicité radio-induite et sur l’étude de leur intérêt en cas de radiothérapie par modulation d’intensité. Six modèles NTCP ont été implémentés et leur paramètres identifiés pour la prédiction des toxicités rectale et vésicale tardives dans le cancer de la prostate. Leur capacité prédictive a été démontrée pour les deux organes. Par ailleurs, le modèle LKB a été utilisé pour la prédiction de l’œsophagite aiguë en cas de radiothérapie du cancer bronchique non à petites cellules. Ensuite, le bénéfice tiré de l’incorporation du paramètre de dose équivalent uniforme (EUD) pour la planification inverse de la radiothérapie par modulation d’intensité (IMRT) a été évalué. L’évaluation de cette approche a montré une baisse significative de la dose dans les parois vésicale et rectale. L’incorporation de plusieurs modèles biologiques dans le processus d’optimisation de l’IMRT a aussi été réalisée. Des fonctions objectif ont été établies pour les différents facteurs biologiques comme le NTCP, l’EUD et le TCP. Les résultats dosimétriques obtenus montrent la supériorité de l’optimisation basée sur des facteurs biologiques sur celle reposant uniquement sur des facteurs physiques. Enfin, les modèles NTCP classiques ont été améliorés en intégrant un paramètre radiobiologique supplémentaire, le rapport α/β. Ce rapport α/β a été identifié pour différents types de toxicité. Avec ce nouveau paramètre, les modèles NTCP peuvent finalement être étendus à des patients traités suivant différents fractionnements, les traitements hypofractionnés étant de plus en plus utilisés
This thesis is focused on the predictive models of irradiation induced toxicities in intensity modulated radiotherapy. Six different NTCP models were implemented and their parameters were identified at predicting late rectal and bladder toxicities in prostate cancer. Their predictive skills have been demonstrated on both organs. Second, LKB model was used to predict the irradiation induced acute esophagitis after nun-small-cell lung cancer. Then, the benefit of using EUD in prostate cancer IMRT inverse planning was evaluated. The evaluation of the proposed approach proved that the use of EUD significantly decreased both the dose in the bladder and rectum walls. Then, the incorporation of different biological models in IMRT optimization process has been realized. Objective functions were established for different biological factors like NTCP, EUD and TCP. Obtained results show the superiority of the optimization based on biological factors over the optimization relying only on physical factors. Finally, classical NTCP models were corrected to deal with another radiobiological parameter, the α/β ratio. With this additional factor, NTCP models can be extended to predict toxicity for patients with different dose fractionation, these kinds of treatments being more and more clinically used
APA, Harvard, Vancouver, ISO, and other styles
2

Helmer, Angelika [Verfasser], Ralf [Gutachter] Kubitz, and Lorenz [Gutachter] Sellin. "Untersuchungen des Gallensalzaufnahmetransporters Ntcp mittels Durchflusszytometrie / Angelika Helmer. Gutachter: Ralf Kubitz ; Lorenz Sellin." Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2016. http://d-nb.info/1102352381/34.

Full text
APA, Harvard, Vancouver, ISO, and other styles
3

Zahner, Daniel. "Gerichtete Mutagenese am Natrium-abhängigen Gallensäuretransporter Ntcp zur Bedeutung negativ geladener Aminosäuren als Natrium-Sensor." Wettenberg : VVB Laufersweiler, 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=969787219.

Full text
APA, Harvard, Vancouver, ISO, and other styles
4

Müller, Simon Franz [Verfasser]. "Speziesunterschiede und Inhibitionscharakterisierung der Interaktion zwischen HBV/HDV und dem spezifischen Rezeptor NTCP / Simon Franz Müller." Gießen : Universitätsbibliothek, 2019. http://d-nb.info/1179693787/34.

Full text
APA, Harvard, Vancouver, ISO, and other styles
5

Müller, Simon [Verfasser]. "Speziesunterschiede und Inhibitionscharakterisierung der Interaktion zwischen HBV/HDV und dem spezifischen Rezeptor NTCP / Simon Franz Müller." Gießen : Universitätsbibliothek, 2019. http://nbn-resolving.de/urn:nbn:de:hebis:26-opus-141234.

Full text
APA, Harvard, Vancouver, ISO, and other styles
6

Zahner, Daniel [Verfasser]. "Gerichtete Mutagenese am Natrium-abhängigen Gallensäuretransporter Ntcp zur Bedeutung negativ geladener Aminosäuren als Natrium-Sensor / Daniel Zahner." Wettenberg : VVB Laufersweiler, 2003. http://d-nb.info/969787219/34.

Full text
APA, Harvard, Vancouver, ISO, and other styles
7

Chimin, Felipe. "Análise dos parâmetros de complicação em tecidos normais (NTCP) em planejamento computadorizado aplicado à radioterapia de tumores de próstata." Botucatu, 2020. http://hdl.handle.net/11449/192416.

Full text
Abstract:
Orientador: Marco Antônio Rodrigues Fernandes
Resumo: O sucesso da radioterapia está intimamente ligado à razão terapêutica que representa o quociente entre a quantidade de tecido tumoral irradiado e o volume de tecido sadio atingido. A Probabilidade de Complicação em Tecidos Normais (NTCP) e a Probabilidade de Controle do Tumor (TCP) são parâmetros fornecidos por Sistemas de Planejamentos de Tratamentos (TPS) computadorizados, usados na rotina da radioterapia que auxiliam na interpretação da qualidade do tratamento. Neste trabalho são analisados os planejamentos de radioterapia de 03 pacientes portadores de câncer de próstata. Os planejamentos dos tratamentos foram realizados no TPS XiO, simulando as técnicas de radioterapia por intensidade modulada de feixe (IMRT) e radioterapia tridimensional conformada (3D-CRT). A dose de radiação preconizada para o volume de tratamento planejado (PTV) foi de 7.600 cGy, as simulações foram realizadas para um arranjo de 6 campos de radiação com feixes de raios X de megavoltagem e energia de 10 MV. Os volumes prostáticos variaram entre 107 cm3 e 143 cm3. A dose de cobertura D98% do PTV variou de 6.940 cGy a 7.570 cGy com IMRT e de 6.410 cGy a 7.250 cGy com 3D-CRT. Os valores obtidos para o TCP ficaram entre 73,5% a 81,1% com IMRT e entre 70,6% a 75,9% com 3D-CRT. Considerando os valores de NTCP para o reto e a bexiga, os maiores valores encontrados foram 6,9% para o reto e 6,1% para a bexiga, ambos planejados com a técnica de 3D-CRT. Para os casos analisados, os resultados mostram que a técnic... (Resumo completo, clicar acesso eletrônico abaixo)
Abstract: The success of radiotherapy is closely related to the therapeutic ratio which represents the ratio of the amount of irradiated tumor tissue to the volume of healthy tissue achieved. Normal Tissue Complication Probability (NTCP) and Tumor Control Probability (TCP) are parameters provided by computerized treatment planning systems (TPS), used in radiotherapy routine and also allow the interpretation of treatment quality. The aim of this work is analyze the planning of 03 cases of patients submitted to prostate cancer radiotherapy. The treatment plans were performed in TPS XiO, simulating the techniques of beam intensity modulated radiotherapy (IMRT) and tree-dimensional conformal radiation therapy (3D-CRT). The recommended radiation dose for the planned treatment volume (PTV) was 7600 cGy, the simulations were performed for an arrangement of 6 radiation fields with megavoltage X-ray beams and 10 MV energy. Prostatic volumes ranged from 107cm3 to 143cm3 . The D98% PTV coverage dose ranged from 6,940 cGy to 7,570 cGy with IMRT and from 6,410 cGy to 7,250 cGy with 3D-CRT. The values obtained for TCP were between 73.5% to 81.1% with IMRT and between 70.6% to 75.9% with 3D-CRT. Considering the NTCP values for the rectum and bladder, the highest values found were 6.9% for the rectum and 6.1% for the bladder, both planned using the 3D-CRT technique. For the analyzed cases, the results show that the IMRT technique presents better NTCP and TCP values than the 3D-CRT technique. These par... (Complete abstract click electronic access below)
Mestre
APA, Harvard, Vancouver, ISO, and other styles
8

Bouezzedine, Fidaa. "Analyse de l'entrée du virus de l'hépatite B : Etude du processus de fusion et de l'effet de l'interleukine 6." Thesis, Rennes 1, 2015. http://www.theses.fr/2015REN1B003/document.

Full text
Abstract:
L’hépatite B est une maladie infectieuse grave et extrêmement contagieuse. Malgré l’existence d’un vaccin efficace plus de 240 millions de personnes souffrent d’une infection hépatique chronique et plus de 780 000 personnes meurent chaque année des conséquences aiguës ou chroniques de l’hépatite B. Les traitements actuels qui consistent en l’utilisation d’interféron et/ou d’inhibiteurs de la réplication virale sont encore insuffisants. De nouvelles thérapeutiques ciblant l’entrée virale sont en développement, notamment le Myrcludex B qui inhibe l’infection en empêchant l’entrée virale. Cependant, les mécanismes d’entrée du VHB dans l’hépatocyte sont encore mal connus. Récemment, l’identification du NTCP comme récepteur spécifique du VHB a permis de mieux comprendre le mécanisme d’attachement de ce virus. Ce récepteur constitue une nouvelle cible pour des antiviraux. C’est aussi un transporteur de sels biliaires fortement régulé par les cytokines pro-inflammatoires. Les objectifs de ce travail étaient : (i) d’étudier la fusion du VHB, étape cruciale de l’entrée d’un virus enveloppé, en établissant un modèle artificiel de fusion entre des particules virales purifiées et des liposomes, et (ii) d’étudier l’effet de l’interleukine 6 sur l’entrée virale. Nous n’avons pas pu mettre en évidence de fusion entre les particules virales et des liposomes suggérant l’incapacité de ce virus à fusionner avec une bicouche lipidique néanmoins il reste possible que des conditions particulières liées aux spécificités du VHB soient requises. Nos résultats ont également montré que l’interleukine 6 inhibait l’entrée virale en diminuant l’expression de NTCP
Hepatitis B is a severe and extremely contagious infectious disease. Despite an effective vaccine more than 240 million people are suffering from chronic infection and over 780 000 persons die each year from the consequences of acute and chronic hepatitis B. Current treatments consisting in the use of interferon and/or viral replication inhibitors are insufficient. New therapeutics targeting viral entry are in progress, such as Myrcludex B that has been shown to inhibit HBV infection by preventing HBV entry. However, the mechanism of HBV entry into hepatocytes is still poorly understood. Recently, the identification of NTCP as a specific HBV receptor allowed us to better understand the attachment of this virus. This receptor is now a target for antiviral molecules. It is also a carrier for bile salts known to be strongly regulated by pro inflammatory cytokines. The aims of our thesis were: (i) to study HBV entry by establishing an artificial model of fusion between purified viral particles and liposomes, and (ii) to study the interleukin 6 effect on viral entry. Our results with fusion assays suggest an absence of fusion in the entry process of this virus. However, fusion could require peculiar conditions related to HBV specificities. Our results also demonstrated that interleukin 6 inhibits virus entry by down-regulating NTCP expression
APA, Harvard, Vancouver, ISO, and other styles
9

Benhacene, Boudam Yasid. "Utilisation des modèles NTCP et de carcinogenèse pour les choix balistiques et de particules en hadronthérapie de l'adulte et de l'enfant." Grenoble 1, 2008. http://www.theses.fr/2008GRE10208.

Full text
Abstract:
Certains problèmes scientifiques et techniques, imparfaitement résolus dans la mise en œuvre des traitements par ions légers ont été étudiés. La thèse développe successivement les trois approches suivantes : 1) La première partie de cette thèse travaille sur la définition de l'équipement (faisceaux fixes versus gantry) pour un centre de traitement et ainsi traiter la plus large variété possible de tumeurs pour un spectre élargi de situations cliniques caractéristiques chez l'adulte. Les tumeurs étudiées sont des tumeurs de la base du crâne, du rachis cervical haut, bronchiques, ganglionnaires thoraciques, ganglionnaires abdominales et de la prostate, l'on obtient ainsi un éventail assez large d'indications thérapeutiques. 2) La seconde partie met à contribution une partie des outils développés dans la première phase (traitement chez l'adulte). Le même design de salle de traitement est utilisé mais pour un ensemble de tumeurs intracrâniennes de la base du crâne et de la sphère ORL chez l'enfant et l'adulte jeune. Il peut être conclu que l'étude de multiples situations anatomo-pathologiques en thérapie protons n'a pas permis de dégager d'incidences faisceaulogiques originales et particulières à la gantry. 3) La dernière phase donne lieu à l'étude des caractéristiques physiques propres aux faisceaux d'ions carbones. Une comparaison est menée sur la base de simulations de données par l'utilisation de modèles de calcul du risque d'induction néoplasique après traitement chez l'adulte et plus spécifiquement chez l'enfant. La simulation semble indiquer que les ions carbones induiraient un phénomène de stérilisation cellulaire à doses intermédiaires & hautes dans les tissus & organes chez l'adulte et l'enfant
The question of the protontherapy is seen through a purely dosimetric aspect. The main question is to know if the multiplication of beam incidences thanks to a gantry allows obtaining an increase of the therapeutic benefit for the patient. These results suggest that a facility equipped with at least three fixed incidences of beam (horizontal, vertical from above and oblique around 50°) could probably treat properly most of the tumour locations. The second part focus on the pediatric cases in protontherapy. The protons as effective inducer of deterministic and stochastic effects in the paediatric tissues are gauged in the discussion. A thorough investigation on the limits and the possibilities offered by the protons for children is proposed. The third part introduces the study of the carbon-ions treatment. Their carcinogenic action is evaluated and compared against the photons, with consideration to the pediatric tissues and organs. The goal is to estimate by simulation if the carbon-ions bring a therapeutic advantage against the photon or proton treatments. The set of complex interactions within the tissues and organs are precisely explained and a simplified approach is brought. In conclusion, the set of complex radiobiological effects acting within tissues to induce different dose-responses of neoplasic risk can have contradictory actions. The standard and the repopulation models provide a comprehensive insight in spite of their purely theoretical aspect. They reveal some encouraging possibilities for the treatment of children by carbon-ions, especially when the choice of hypofractionation will be possible
APA, Harvard, Vancouver, ISO, and other styles
10

Mayer, Patrick [Verfasser]. "Die Regulation der Plasmamembranlokalisation der Gallensalztransporter Natrium-Taurocholat-Cotransporter (Ntcp) und Bile salt export pump (Bsep) durch Glykochenodeoxycholsäure, Hyperosmolarität und Tauroursodeoxycholsäure / Patrick Mayer." Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2021. http://d-nb.info/123639965X/34.

Full text
APA, Harvard, Vancouver, ISO, and other styles
More sources

Books on the topic "NTCP"

1

Namibia. Ministry of Health and Social Services. TB: National TB Control Programme (NTCP) review, August 2000. [Windhoek]: Republic of Namibia, Ministry of Health and Social Service, 2000.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
2

Liska, Allan. NTP Security. Berkeley, CA: Apress, 2016. http://dx.doi.org/10.1007/978-1-4842-2412-0.

Full text
APA, Harvard, Vancouver, ISO, and other styles
3

Lasorsa, Rob. 2008 NTCA throws handbook. Monterey, CA: Coaches Choice, 2007.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
4

Lasorsa, Rob. 2008 NTCA throws handbook. Monterey, CA: Coaches Choice, 2007.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
5

G, Popova A., and Institut Evropy (Rossiĭskai︠a︡ akademii︠a︡ nauk), eds. Evropa: Vyzovy sovremennogo NTP. Moskva: In-t Evropy RAN, 2002.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
6

Sbytov, Vladimir Filippovich. Inzhener--kli͡u︡chevai͡a︡ figura NTP. Moskva: "Ėkonomika", 1989.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
7

Aliev, V. G. NTP i podgotovka proizvodstva. Moskva: Ekonomika, 1987.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
8

NTP i podgotovka proizvodstva. Moskva: Ėkonomika, 1987.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
9

Sbytov, V. F. Inzhener - klyuchevaya figura NTP. Moskva: Ekonomika, 1989.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
10

Zykov, I︠U︡riĭ Anatolʹevich. Aktualʹnye problemy ėkonomiki NTP. Moskva: Nauka, 1986.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
More sources

Book chapters on the topic "NTCP"

1

Tsukuda, Senko, Masashi Iwamoto, and Koichi Watashi. "NTCP (Sodium Taurocholate Cotransporting Polypeptide)." In Encyclopedia of Signaling Molecules, 3591–99. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-67199-4_101735.

Full text
APA, Harvard, Vancouver, ISO, and other styles
2

Troicki, Filip T., Filip T. Troicki, Filip T. Troicki, Carlos A. Perez, Wade L. Thorstad, Brandon J. Fisher, Larry C. Daugherty, et al. "Normal Tissue Complication Probability (NTCP)." In Encyclopedia of Radiation Oncology, 560. Berlin, Heidelberg: Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-540-85516-3_341.

Full text
APA, Harvard, Vancouver, ISO, and other styles
3

Tsukuda, Senko, Masashi Iwamoto, and Koichi Watashi. "NTCP (Sodium Taurocholate Cotransporting Polypeptide)." In Encyclopedia of Signaling Molecules, 1–8. New York, NY: Springer New York, 2017. http://dx.doi.org/10.1007/978-1-4614-6438-9_101735-1.

Full text
APA, Harvard, Vancouver, ISO, and other styles
4

Gulliford, Sarah, and Issam El Naqa. "Modelling of Radiotherapy Response (TCP/NTCP)." In Machine and Deep Learning in Oncology, Medical Physics and Radiology, 399–437. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-83047-2_17.

Full text
APA, Harvard, Vancouver, ISO, and other styles
5

Gulliford, Sarah. "Modelling of Normal Tissue Complication Probabilities (NTCP): Review of Application of Machine Learning in Predicting NTCP." In Machine Learning in Radiation Oncology, 277–310. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-18305-3_17.

Full text
APA, Harvard, Vancouver, ISO, and other styles
6

Sun, Yinyan, Yonghe Qi, Bo Peng, and Wenhui Li. "NTCP-Reconstituted In Vitro HBV Infection System." In Methods in Molecular Biology, 1–14. New York, NY: Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4939-6700-1_1.

Full text
APA, Harvard, Vancouver, ISO, and other styles
7

L. Kerns, Sarah, Suhong Yu, and Catharine M. L. West. "Including Genetic Variables in NTCP Models Where Are We? Where Are We Going?" In Modelling Radiotherapy Side Effects, 455–67. Boca Raton, FL : CRC Press, Taylor & Francis Group, [2019] |: CRC Press, 2019. http://dx.doi.org/10.1201/b21956-19.

Full text
APA, Harvard, Vancouver, ISO, and other styles
8

König, Alexander, and Dieter Glebe. "Live Cell Imaging Confocal Microscopy Analysis of HBV Myr-PreS1 Peptide Binding and Uptake in NTCP-GFP Expressing HepG2 Cells." In Methods in Molecular Biology, 27–36. New York, NY: Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4939-6700-1_3.

Full text
APA, Harvard, Vancouver, ISO, and other styles
9

Liska, Allan. "Understanding NTP." In NTP Security, 1–21. Berkeley, CA: Apress, 2016. http://dx.doi.org/10.1007/978-1-4842-2412-0_1.

Full text
APA, Harvard, Vancouver, ISO, and other styles
10

Liska, Allan. "Issues in NTP Security." In NTP Security, 23–35. Berkeley, CA: Apress, 2016. http://dx.doi.org/10.1007/978-1-4842-2412-0_2.

Full text
APA, Harvard, Vancouver, ISO, and other styles

Conference papers on the topic "NTCP"

1

Zhuo Jiang, Qian Wu, and Hewu Li. "NTCP: Network assisted TCP for long delay satellite network." In 2016 IEEE/CIC International Conference on Communications in China (ICCC Workshops). IEEE, 2016. http://dx.doi.org/10.1109/iccchinaw.2016.7586710.

Full text
APA, Harvard, Vancouver, ISO, and other styles
2

Guo, Chenkai, and Jingyu Luo. "Hepatitis B virus infection: Overview and new treatment targeting NTCP." In 4TH INTERNATIONAL CONFERENCE ON FRONTIERS OF BIOLOGICAL SCIENCES AND ENGINEERING (FBSE 2021). AIP Publishing, 2022. http://dx.doi.org/10.1063/5.0094816.

Full text
APA, Harvard, Vancouver, ISO, and other styles
3

"NTCA 2020 Index." In 2020 New Trends in Civil Aviation (NTCA). IEEE, 2020. http://dx.doi.org/10.23919/ntca50409.2020.9290952.

Full text
APA, Harvard, Vancouver, ISO, and other styles
4

"NTCA 2020 Preface." In 2020 New Trends in Civil Aviation (NTCA). IEEE, 2020. http://dx.doi.org/10.23919/ntca50409.2020.9290983.

Full text
APA, Harvard, Vancouver, ISO, and other styles
5

"NTCA 2020 TOC." In 2020 New Trends in Civil Aviation (NTCA). IEEE, 2020. http://dx.doi.org/10.23919/ntca50409.2020.9291082.

Full text
APA, Harvard, Vancouver, ISO, and other styles
6

Danko, G. "Numerical Transport Code Functionalization Procedure and Software Functions." In ASME 2004 Heat Transfer/Fluids Engineering Summer Conference. ASMEDC, 2004. http://dx.doi.org/10.1115/ht-fed2004-56049.

Full text
Abstract:
A numerical–computational procedure is described to determine a multi-dimensional functional or an operator for the representation of the computational results of a numerical transport code. The procedure is called Numerical Transport Code Functionalization (NTCF). Numerical transport codes represent a family of engineering software to solve, for example, heat conduction problems in solids using ANSYS; heat and moisture transport problems in porous media using NUFT; or laminar or turbulent flow and transport problems using FLUENT, a computational fluid dynamic (CFD) model. The NTCF procedure is developed to determine a model for the representation of the code for a variety of input functions. Couple solution of multiphysics problems often require repeated, iterative calculations for the same model domain and with the same code, but with different boundary condition values. The NTCF technique allows for reducing the number of runs with the original numerical code to the number of runs necessary for NTCF model identification. The NTCF procedure is applied for the solution of coupled heat and moisture transport problems at Yucca Mountain, Nevada. The NTCF method and the supporting software is a key element of MULTIFLUX, a coupled thermohydrologic-ventilation model and software. Numerical tests as well as applications for Yucca Mountain, Nevada are presented using both linear and nonlinear NTCF models. The performance of the NTCF method is demonstrated both in accuracy and modeling acceleration.
APA, Harvard, Vancouver, ISO, and other styles
7

"NTCA 2020 Breaker Page." In 2020 New Trends in Civil Aviation (NTCA). IEEE, 2020. http://dx.doi.org/10.23919/ntca50409.2020.9291077.

Full text
APA, Harvard, Vancouver, ISO, and other styles
8

"NTCA 2020 Breaker Page." In 2020 New Trends in Civil Aviation (NTCA). IEEE, 2020. http://dx.doi.org/10.23919/ntca50409.2020.9291215.

Full text
APA, Harvard, Vancouver, ISO, and other styles
9

"NTCA 2020 Cover Page." In 2020 New Trends in Civil Aviation (NTCA). IEEE, 2020. http://dx.doi.org/10.23919/ntca50409.2020.9291094.

Full text
APA, Harvard, Vancouver, ISO, and other styles
10

"NTCA 2020 Breaker Page." In 2020 New Trends in Civil Aviation (NTCA). IEEE, 2020. http://dx.doi.org/10.23919/ntca50409.2020.9291121.

Full text
APA, Harvard, Vancouver, ISO, and other styles

Reports on the topic "NTCP"

1

Lussier, James W., Rex Michael, and Adela Frame. NTC-CD System: Recreating the NTC Experience. Fort Belvoir, VA: Defense Technical Information Center, February 1997. http://dx.doi.org/10.21236/ada328363.

Full text
APA, Harvard, Vancouver, ISO, and other styles
2

Christians, Nick, Adam Thoms, and Isaac Mertz. NTEP Kentucky Bluegrass Study. Ames: Iowa State University, Digital Repository, 2017. http://dx.doi.org/10.31274/farmprogressreports-180814-1612.

Full text
APA, Harvard, Vancouver, ISO, and other styles
3

Christians, Nick, Adam Thoms, and Isaac Mertz. NTEP Perennial Ryegrass Study. Ames: Iowa State University, Digital Repository, 2017. http://dx.doi.org/10.31274/farmprogressreports-180814-1613.

Full text
APA, Harvard, Vancouver, ISO, and other styles
4

Christians, Nick, Adam Thoms, Ben Pease, and Isaac Mertz. NTEP Perennial Ryegrass Study. Ames: Iowa State University, Digital Repository, 2018. http://dx.doi.org/10.31274/farmprogressreports-180814-2059.

Full text
APA, Harvard, Vancouver, ISO, and other styles
5

Christians, Nick, Dan Strey, and Ryan Adams. NTEP Kentucky Bluegrass Study 2014. Ames: Iowa State University, Digital Repository, 2015. http://dx.doi.org/10.31274/farmprogressreports-180814-2494.

Full text
APA, Harvard, Vancouver, ISO, and other styles
6

Christians, Nick, and Dan Strey. NTEP Perennial Ryegrass Study 2015. Ames: Iowa State University, Digital Repository, 2016. http://dx.doi.org/10.31274/farmprogressreports-180814-59.

Full text
APA, Harvard, Vancouver, ISO, and other styles
7

Christians, Nick, and Dan Strey. NTEP Kentucky Bluegrass Study 2015. Ames: Iowa State University, Digital Repository, 2016. http://dx.doi.org/10.31274/farmprogressreports-180814-60.

Full text
APA, Harvard, Vancouver, ISO, and other styles
8

Christians, Nick, Dan Strey, and Ryan Adams. NTEP Perennial Ryegrass Study 2014. Ames: Iowa State University, Digital Repository, 2015. http://dx.doi.org/10.31274/farmprogressreports-180814-998.

Full text
APA, Harvard, Vancouver, ISO, and other styles
9

Strey, Dan, Nick Christians, and Ryan Adams. NTEP Fairway Height Bentgrass Study 2014. Ames: Iowa State University, Digital Repository, 2015. http://dx.doi.org/10.31274/farmprogressreports-180814-129.

Full text
APA, Harvard, Vancouver, ISO, and other styles
10

Christians, Nick, Adam Thoms, and Isaac Mertz. NTEP Turf-Type Tall Fescue Study. Ames: Iowa State University, Digital Repository, 2017. http://dx.doi.org/10.31274/farmprogressreports-180814-1614.

Full text
APA, Harvard, Vancouver, ISO, and other styles
You might also be interested in the extended bibliographies on the topic 'NTCP' for particular source types:
Journal articles Dissertations / Theses Books
We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!

To the bibliography