Dissertations / Theses on the topic 'NSET'
To see the other types of publications on this topic, follow the link: NSET.
Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles
Consult the top 50 dissertations / theses for your research on the topic 'NSET.'
Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.
You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.
Browse dissertations / theses on a wide variety of disciplines and organise your bibliography correctly.
1
Diriwari, Peremobowei Iyanu. "Resonance Energy Transfer within and to optical Nanoparticles for Bioimaging and Biosensing Applications." Electronic Thesis or Diss., Normandie, 2024. http://www.theses.fr/2024NORMR007.
Abstract:
La biosensibilité et la bio-imagerie basées sur la fluorescence jouent des rôles cruciaux dans le développement d'outils de diagnostic rapides et hautement sensibles pour la détection précoce des maladies et la mise en oeuvre d’une médecine de terrain efficace. Cependant, ces techniques nécessitent une certaine optimisation pour obtenir des images haute résolution et des limites de détection très faibles. Cette thèse se concentre sur l'utilisation de nanoparticules optiques et de mécanismes de transfert d'énergie résonant pour des applications avancées en bio-imagerie et en détection de biomolécules. Je présente les analyses spectroscopiques de nanoclusters d'or luminescents encapsulés dans des polymères (AuNC-NPs) adaptés à la bio-imagerie dans la région infrarouge à ondes courtes (SWIR). L’étude des deux temps de vie de luminescence communément décrits dans les AuNCs m’a permis d’obtenir de nouveaux éléments pour comprendre l’origine de leur luminescence. J’ai découvert que ces temps de vie ne sont pas sensibles de la même manière à l’extinction par homoFRET ce qui suggèrent qu’ils sont causés par des mécanismes différents et des parties distincts de ces nano-objets telles que leur surface constituée de thiolate d’or et leur coeur. J'ai également caractérisé une nouvelle famille de complexes de terbium de CoraFluor (CRF) avec plusieurs méthodes spectroscopiques. J'ai découvert qu'ils sont un donneur de transfert d'énergie applicable en tant que sonde FRET et NSET. J'ai atteint des limites sub-nanomolaires pour la détection de points quantiques et j'ai appliqué ce système pour détecter le récepteur du facteur de croissance épidermique (EGFR). Cette thèse décrit le rôle pivot des mécanismes RET, en particulier du FRET, dans l'avancement des technologies de biosensibilité et de bio-imagerie basées sur la fluorescence. Grâce à des conceptions innovantes de nanoparticules et à une utilisation stratégique des complexes Corafluor Tb, l'étude vise à améliorer la résolution de la bio-imagerie dans la région SWIR et à améliorer la sensibilité, la spécificité et l'applicabilité des outils de diagnostic, contribuant ainsi à l'avancement de la médecine de précision et de la gestion des maladiesFluorescence-based biosensing and bioimaging play crucial roles in developing rapid and highly sensitive diagnostic tools for early detection of diseases and effective point-of-care medicine. However, these techniques require some optimisation to attain high-resolution images and very low detection limits. This thesis focuses on utilising luminescent nanoparticles and Resonance energy transfer mechanisms for advanced bioimaging and biosensing applications. I present the spectroscopic analyses of bright polymer encapsulated gold nanoclusters (AuNC-NPs) suitable for bioimaging in the shortwave infrared (SWIR) region. My study of the two photoluminescence lifetimes commonly measured in AuNCs allowed me to gather new insight to understand the origin of their luminescence. I discovered that each of these lifetimes are not sensitive in the same way to homo FRET suggesting that they originate from distinct mechanisms and distinct parts of the AuNCs such as the gold thiolate surface or the core of the nano-object. I have also characterised a new family of terbium complexes from CoraFluor (CRF) with several spectroscopic methods. I have found that they are a suitable energy transfer donor for FRET and NSET biosensing applications with gold nanoparticles. I attained sub-nanomolar limits of detection of quantum dots and have applied the system to detect the epidermal growth factor receptor (EGFR). This thesis describes the pivotal role of RET mechanisms, particularly FRET, in advancing fluorescence-based biosensing and bioimaging technologies. With innovative nanoparticle designs and strategic use of Corafluor Tb complexes, the study aims to enhance the bioimaging resolution in the SWIR region and improve diagnostic tool sensitivity, specificity and applicability, contributing to advancing precision medicine and disease management
2
Viana, Rodrigo Sartorelo Salemi. "Espectrometria e reconstrução de imagens tomográficas de emissão estimulada por nêutrons via algoritmo EM e método de Monte Carlo." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/85/85133/tde-26052014-130835/.
Abstract:
A NSECT figura como uma nova técnica espectrográfica capaz de avaliar in vivo a concentração de elementos utilizando a reação de espalhamento inelástico (n,n). Desde sua introdução, várias melhorias vem sendo propostas com o objetivo de investigar aplicações para o diagnóstico clínico e redução da dose absorvida associada à aquisição tomográfica. Neste contexto, são apresentadas duas novas aplicações de diagnóstico utilizando as abordagens espectroscópica e tomográfica da NSECT. Uma nova metodologia também foi proposta para otimizar a amostragem do sinograma que está diretamente relacionado com a qualidade de reconstrução através do protocolo de irradiação. Os estudos realizados foram desenvolvidos com base em simulações com o código MCNP5. O diagnóstico de Carcinoma de Célula Renal (CCR) e a detecção de microcalcificações mamárias foram avaliadas nos estudos conduzidos utilizando um objeto simulador humano. Os resultados obtidos demonstram a habilidade da técnica NSECT em detectar a alteração da composição dos tecidos modelados em função do desenvolvimento das patologias avaliadas. O método proposto para a otimização dos sinogramas foi capaz de simular analiticamente a composição do meio irradiado permitindo que a qualidade de reconstrução e a dose efetiva fossem avaliados em função da taxa de amostragem. Entretanto, futuras pesquisas devem ser conduzidas para quantificar o limiar de detecção de acordo com os elementos selecionados.The NSECT figures as a new spectrographic technique able to evaluate in vivo the concentration of elements using the inelastic scattering reaction (n,n). Since its introduction, several improvements have been proposed with the aim of investigating applications for clinical diagnosis and reduction of absorbed dose associated with CT acquisition. In this context, two new diagnostic applications are presented using spectroscopic and tomographic approaches from NSECT. A new methodology has also been proposed to optimize the sinogram sampling that is directly related to the quality of the reconstruction by the irradiation protocol. The studies were developed based on simulations with MCNP5 code. Diagnosis of Renal Cell Carcinoma (RCC) and the detection of breast microcalcifications were evaluated in studies conducted using a human phantom. The obtained results demonstrate the ability of the NSECT technique to detect changes in the composition of the modeled tissues as a function of the development of evaluated pathologies. The proposed method for optimizing sinograms was able to analytically simulate the composition of the irradiated medium allowing the assessment of quality of reconstruction and effective dose in terms of the sampling rate. However, future research must be conducted to quantify the sensitivity of detection according to the selected elements.
3
Yaringaño, Malpartida Paul Erick. "Ejecución de pruebas funcionales para certificar la aplicación NSAT (INTERBANK)." Bachelor's thesis, Universidad Nacional Mayor de San Marcos, 2018. https://hdl.handle.net/20.500.12672/10197.
Abstract:
Describe la ejecución de las pruebas funcionales para certificar la aplicación NSAT (Nuevo Sistema de Administración de Tarjetas) del banco Interbank. Esta aplicación web es la encargada de soportar los principales procesos de las tarjetas de crédito; así como altas de tarjetas de crédito, transacciones, liquidación, interfaces y reportes. Las pruebas fueron aplicadas a determinadas funcionalidades de la aplicación (Según especificación funcional proporcionada por el banco) como parte de la certificación que se realizó previo al pase a producción de las funcionalidades impactadas por los cambios y/o mejoras.Trabajo de suficiencia profesional
4
De, La Torre Sousa César Augusto, Navarro Catherine Vanessa Figueroa, Rios Carlos Flavio Huamaní, and Rodríguez César Oswaldo Ramírez. "Factores críticos del sector inmobiliario para incursionar del NSE A y B al NSE C y D de Lima Metropolitana." Master's thesis, Pontificia Universidad Católica del Perú, 2013. http://tesis.pucp.edu.pe/repositorio/handle/123456789/8696.
Abstract:
xiii, 163 h. : il. ; 30cm.La investigación se centra en conocer los factores críticos para incursionar en el sector inmobiliario con departamentos en los niveles socioeconómicos (NSE) C y D para que promotores-constructores de pequeñas empresas de Lima Metropolitana, quienes actualmente construyen para los NSE A y B, puedan enfocar sus ventas en dichos niveles socioeconómicos. El conocimiento de los factores críticos, la identificación del tipo de mindset de un grupo de promotores-constructores entrevistados de pequeñas empresas y la propuesta de un tipo de departamento para incursionar en sectores populares ayudarán a solucionar en parte la problemática de aquellos promotores-constructores que no pueden dirigirse a los NSE C y D con proyectos masivos, permitiendo que estas empresas tengan mayores posibilidades de ampliar sus mercados y aprovechar las oportunidades que presenta la coyuntura inmobiliaria donde la demanda de viviendas en dicho sector sigue creciendo y la oferta actual no es suficiente. La investigación es del tipo exploratorio y ha utilizado un enfoque cualitativo. La muestra de promotores-constructores fue no probabilística, bajo el tipo experto y homogéneo. Los datos fueron recolectados de entrevistas en profundidad con una guía de preguntas que se indican en el capítulo 3. Las respuestas han sido grabadas y transcritas con la autorización de los entrevistados. Para procesar la información, se usó como herramienta el software Atlas TI, el cual permitió agrupar las respuestas de cada entrevistado ordenándolas de acuerdo con la antigüedad en el negocio. Los resultados indican que los factores críticos son cinco: parámetros urbanísticos del distrito, respaldo económico, importancia en la compra del terreno, optimización de los costos en la construcción y experiencia del promotor. Asimismo, se infiere que el tipo de mindset predominante en el grupo de promotores-constructores entrevistados es del tipo no empresarial, constringente y colectivo. III A partir de estos resultados, se construye un gráfico (mapa mental) de la relación entre los factores críticos y el tipo de mindset, para luego generar cuatro proposiciones que explica la relación del factor parámetros urbanísticos con el tipo de mindset fixed. Asimismo, el de los factores respaldo económico, compra de terreno y experiencia del promotor con el tipo de mindset constringente, y el del factor optimizar costos en construir con el tipo de mindset no empresarial. Sobre la alternativa de un tipo de departamento para incursionar en los NSE C y D en forma no masiva, se propone departamentos tipo loft, al ser un ambiente con pocos muros y espacios integrados de acuerdo con lo mencionado en el capítulo 2. El loft permite optimizar los costos de construcción, que es uno de los factores críticos identificados. Esta propuesta de vivienda puede dirigirse a los siguientes grupos sociales de los NSE C y D: (a) jóvenes profesionales y estudiantes universitarios; (b) personas con estilo de vida del tipo emprendedores y sensoriales, seleccionado de Arellano (2003); (c) hogares con pocos integrantes como los del tipo partida, tipo inicio y tipo fuera de ciclo, tomado de Ipsos Apoyo (2012); y (d) inversionistas. Las ventajas de ofrecer departamentos tipo loft para los NSE C y D son: (a) ampliación del negocio, al captar un público objetivo cuya demanda de vivienda no es atendida; y (b) al ser un departamento de transición, se podría construir mayor número de ambientes de uno o dos dormitorios para un público objetivo específico
The research is focused on identifying the critical factors to invest in real estate with apartments designed for socioeconomic status C and D so order that the developers-builders, which belong to small companies of Lima Metropolitan, who currently build for socioeconomic status A and B wil focus their sales in socioeconomic status C and D. Identifying the critical factors, finding the type of mindset of the group of developersbuilders, which compose the research sample, and proposing a type of housing, mainly apartments, to move into popular sectors, will help party to solve the problems of those developers-builders who currently can not address the socioeconomic status C and D with massive projects, allowing these companies to have greater opportunities to expand their markets and take advantage of opportunities presented by the real estate situation where the demand for housing in said sectors continues to grow and the current supply is not sufficient. The research is exploratory and uses a qualitative approach. The developers-builders sample was not random under the expert and homogeneous type. Data were collected from interviews with a guide of questions listed in Chapter 3. The responses were recorded and transcribed with the permission of the interviewees. In order to process the data we used a software tool called Atlas TI which allowed us to group the responses of each interviewee according to their years of experience in the business. The results showed five critical factors: zoning parameters of the districts, economic support, importance of the land purchase, optimization of construction cost and the developer´s experience. Also, it seems that the type of mindset prevalent in the group of developers-builders is the non-business, constricting and collectivistic type. From these results we built a graphical map of the relationship between the critical factors and the type of mindset, in order to generate four proposals that will explain, for instance, the relationship among the zoning parameters of districts, the fixed mindset, the V economic support, the important of the land purchase and developer´s experience with the constricting mindset, and finally the optimization of construction cost with the non-business mindset. The type of housing proposed to venture into socioeconomic status C and D in a nonmassive way will be the loft apartment since it implies few walls and integrated spaces as mentioned in Chapter 2. The loft apartment allows optimizing construction costs, which is one of the critical factors identified. The target market for this type of housing in the socioeconomic status C and D will be: (a) young professionals and college students, (b) people with an enterprising and sensorial lifestyle, according to author Arellano (2003), (c) households with few members such as departure type, initiation type and off-cycle type, taken from Ipsos Apoyo (2012), and (d) investors. The advantages of offering loft apartments for socioeconomic status C and D are: (a) business expansion identifying a target audience whose housing demands are not satisfied, and (b) building a higher number of one or two-bedroom apartments for a specific target audience
Tesis
5
Krohn, Michael. "Immunhistochemische Untersuchungen mittels S100 und NSE nach Schädel-Hirn-Trauma." Doctoral thesis, Universitätsbibliothek Leipzig, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-189289.
Abstract:
1. Hintergrund
Das Schädel-Hirn-Trauma (SHT) stellt eine der häufigsten Todesursachen und Begleitverletzungen bei nichtnatürlichen Todesfällen dar und ist damit Gegenstand der Routine-Untersuchungen in der Rechtsmedizin. Eine Abschätzung der Überlebenszeit (ÜLZ, d.h. der Zeitraum zwischen der Verletzungsentstehung und dem Todeseintritt) ist für die Chronologie eines Tatablaufs und Überprüfung von Zeugenaussagen / Alibiangaben von großer Bedeutung. Primär werden hierfür postmortal pathomorphologische und klassische histologische Befunde herangezogen. Immunhistochemische Untersuchungen haben bisher kaum Eingang in die Überlebenszeitdiagnostik gefunden, könnten aber zur Konkretisierung der bisher gängigen Methoden beitragen.
Häufig untersuchte Proteine im Gehirn sind das S100-Protein (S100) und die Neuronenspezifische Enolase (NSE). Die Spiegel beider Marker werden im klinischen Alltag vielfach zur Abschätzung der Schwere und der Prognose eines SHT im Blut und Liquor gemessen. Immunhistochemisch wurden beide Proteine bisher vor allem auf deren allgemeines Vorhandensein und Verteilung im Zusammenhang mit SHT untersucht. Nur eine Studie beschäftigte sich bisher mit einer möglichen zeitlichen Dynamik.
2. Fragestellungen
Folgende Fragen sollten durch vorliegende Arbeit beantwortet werden:
Existiert eine Korrelation zwischen dem Anteil positiv auf S100 gefärbter Gliazellen (Astroglia und Oligodendroglia) und der Überlebenszeit?
Ist eine Korrelation zwischen dem Anteil positiv auf NSE gefärbter Neuronen und der Überlebenszeit möglich?
Welche lokalisationsspezifische Veränderungen in den untersuchten Hirnregionen (Umgebung der Kontusion, Hippocampus, Kleinhirn) in Bezug auf die Überlebenszeit existieren?
Gibt es signifikante Unterschiede zwischen Fall- und Kontrollgruppe?
3. Material und Methoden
Für diese Untersuchung wurden Hirngewebeproben aus 57 gerichtlich angeordneten Sektionen verwendet. Davon wiesen 47 ein tödliches SHT und ÜLZ zwischen wenigen Sekunden und 34 Tagen auf. Zehn Fälle mit kardiovaskulären Todesursachen wurden als Kontrolle herangezogen. Die Überlebenszeiten der Fälle mit tödlichem SHT wurden in Übereinstimmung mit bisherigen Studien in folgende Kategorien eingeteilt: Akuter Todeseintritt nach SHT (ÜLZ bis 2 Stunden), subakuter Todeseintritt nach SHT (ÜLZ 2 Stunden bis 4 Tage) und verzögerter Todeseintritt nach SHT (ÜLZ über 4 Tage). Die zur Untersuchung gelangten Proben wurden spätestens 6 Tage nach dem Versterben der Personen entnommen (Mittelwert 2,7 Tage).
In allen Fällen wurde die Umgebung der Kontusion, bei 35 dieser Fälle der Hippocampus und bei 31 der Fälle auch das Kleinhirn untersucht. Die verschiedenen Regionen wurden jeweils gesondert für Rinde und Mark bzw. im Hippocampus für Stratum pyramidale und radiatum beurteilt.
Die immunhistochemische Färbung auf S100 und NSE wurde mit der indirekten Dextran-Polymer-Methode (DakoCytomation), die Gegenfärbung mit Hämatoxylin nach Mayer durchgeführt. Verwendet wurden ein polyklonaler S100-Kaninchen-Antikörper sowie ein monoklonaler NSE-Maus-Antikörper (beide DakoCytomation).
Für die semiquantitative Evaluation wurden gefärbte und ungefärbte Neuronen, Oligodendrozyten sowie Astrozyten in jeweils 20 High Power Fields gezählt. So konnte für jede Region und Zellart ein Prozentsatz positiver Zellen ermittelt werden.
Für die statistische Auswertung wurde SPSS Statistics (Version 21, 2012 IBM) und OpenOffice Calc (Version 3.4.1, 2012 Apache Software Foundation) verwendet, es kamen der Mann-Whitney-Wilcoxon-Test (nicht-parametrisch), die Spearman-Korrelation und die Benjamini-Hochberg-Prozedur zum Einsatz.
Eine Zustimmung zu dem der Promotionsschrift zugrunde liegendem Forschungsvorhaben wurde durch die Ethik-Kommission der Medizinischen Fakultät der Universität Leipzig erteilt (Nr. 117-12-23012012).
4. Ergebnisse
Äußere Einflüsse. Es konnte keine Korrelation zwischen dem Anteil positiver Zellen und der Leichenliegezeit (rs= -0.27 bis 0.15, p = 0.1 bis 0.96) oder dem Geschlecht (p = 0.07 bis 0.98) festgestellt werden. Aufgrund des häufigeren Auftretens verzögerter Todeseintritte bei älteren Personen (rs = 0,33, p < 0.05) konnte keine sinnvolle Korrelation zwischen Alter und Zellpositivität durchgeführt werden.
Zellzahlen insgesamt. Zur Qualitätssicherung und zur Vergleichbarkeit mit anderen Studien, wurden die Zellzahlen insgesamt erfasst. Hierbei wurden keine signifikanten Unterschiede in den unterschiedlichen ÜLZ-Kategorien festgestellt. Die Zellzahlen in den SHT-Fällen waren hingegen signifikant niedriger als in den Kontrollfällen.
Unterschiede in den Kategorien der Überlebenszeit. Die Anteile S100-positiver Oligodendrozyten waren in Kontusionsumgebung signifikant niedriger in der Gruppe mit subakutem Todeseintritt als in der Gruppe mit akutem Todeseintritt (p < 0,05) sowie der Kontrollgruppe (p < 0,05). Im Hippocampus waren die Anteile S100-positiv gefärbter Oligodendrozyten in der Gruppe der akuten sowie subakuten Todeseintritte niedriger als in der Kontrollgruppe (jeweils p < 0,05).
Im Vergleich mit der Kontrollgruppe waren die Anteile NSE-positiver Neuronen sowohl im Hippocampus als auch in der Kontusionsumgebung in der Gruppe der akuten Todeseintritte (jeweils p < 0,05) höher. Die Anteile NSE-positiver Neuronen im Hippocampus sanken in der Gruppe der subakuten im Vergleich zur Gruppe der akuten Todeseintritte ab (p < 0,05).
Astrozyten zeigten bei dieser Studie keine signifikanten Unterschiede in ihrem Färbeverhalten in Bezug auf die ÜLZ.
Überraschenderweise zeigten sich in den Gruppen mit subakutem und verzögertem Todeseintritt auch S100-positive Neuronen im Hippocampus und der Kontusionsumgebung. Diese Beobachtung konnte in der Akutphase nach Traumatisierung und in der Kontrollgruppe nicht gemacht werden.
Im Hippocampus war eher eine diffuse neuroplasmatische, in der Kontusionsumgebung eine eher juxtanukleäre Färbung zu finden. In beiden Regionen war die Verteilung der S100-positiven Neuronen unsystematisch oft in räumlicher Nähe zu S100-positiven Gliazellen zu finden.
6
Fürst, Elmar Wilhelm M. "Die neue Güternomenklatur für die Verkehrsstatistiken: NST 2007." STATISTIK AUSTRIA, Bundesanstalt Statistik Österreich, 2010. http://epub.wu.ac.at/5744/1/Fuerst_Verkehr_09_2010.pdf.
Abstract:
Mit dem Berichtsjahr 2008 wurde für die im Bereich der Verkehrsstatistiken an Eurostat meldenden Länder eine neue Güternomenklatur, NST 2007, verpflichtend eingeführt. Damit wurde die bislang geltende Klassifikation, die sogenannte NST/R, für die Meldungen an die Europäische Union (EU) abgelöst. Der Vorteil der NST 2007 - die lange und intensiv vorbereitet wurde - liegt in einer besseren Abstimmung mit anderen Klassifikationen. Der folgende Artikel gibt einen Überblick über deren Entwicklung und Inhalt.
7
Ulrich, Anett. "S100B-Protein und Neuronenspezifische Enolase bei leichten Schädel-Hirn-Verletzungen im Kindesalter." Doctoral thesis, Universitätsbibliothek Leipzig, 2011. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-63800.
Abstract:
Fragestellung: Gegenstand dieser Untersuchung ist der diagnostische Nutzen der Neuro-Biomarker S100B-Protein und Neuronenspezifische Enolase (NSE) bei leichten Schädel-Hirn-Verletzungen im Kindesalter. Es wird untersucht, ob anhand der posttraumatischen S100B- und NSE-Serum-Konzentrationen Kinder mit einer Schädelprellung und einem leichten Schädel-Hirn-Trauma (SHT) differenziert werden können.
Material und Methode: In einer prospektiven, klinischen Studie werden die posttraumatischen S100B- und NSE-Serum-Konzentrationen von Kindern im Alter zwischen 6 Monaten und 15 Jahren mit einer Schädelprellung oder einem leichten SHT untersucht. Kinder mit extrakraniellen Begleitverletzungen und Begleiterkrankungen sind ausgeschlossen. Die Blutentnahme erfolgt innerhalb von 6 Stunden nach dem Trauma. Es werden 2 diagnostische Gruppen definiert: Gruppe 1: asymptomatische Schädelprellungen (Glasgow-Coma-Scale [GCS] 15 Punkte), Gruppe 2: leichte SHT (GCS 13-15 Punkte) mit klinischen Zeichen einer Gehirnerschütterung (kurze Bewusstlosigkeit, Amnesie, Übelkeit, Erbrechen, Somnolenz, Kopfschmerzen, Schwindel, Sehstörungen, Kreislaufreaktion). Die S100B- und NSE- Konzentrationen werden zwischen beiden Diagnosegruppen verglichen. Die Korrelation zwischen S100B und NSE sowie zwischen den Markern und dem Alter der Kinder, dem Zeitraum zwischen Trauma und Blutentnahme, dem GCS-Wert und dem Vorhandensein von Kopfplatzwunden wird analysiert.
Ergebnisse: 148 Kinder sind in die Studie eingeschlossen (53 Kinder mit einer Schädelprellung und 95 mit einem leichten SHT). Nach Adjustierung der gemessenen Marker-Konzentrationen auf Unterschiede im Alter und Zeitraum zwischen Trauma und Blutentnahme unterscheiden sich die S100B- und NSE-Konzentrationen nicht signifikant zwischen Kindern mit einer Schädelprellung und einem leichten SHT. Zwischen den S100B- und NSE-Konzentrationen besteht eine signifikant positive Korrelation. Beide Marker korrelieren signifikant negativ mit dem Alter und dem Entnahmezeitraum. Der GCS-Wert und das Vorhandensein von Kopfplatzwunden zeigen keinen Effekt auf die Marker-Konzentrationen.
Schlussfolgerung: Die posttraumatischen S100B- und NSE-Serum-Konzentrationen zeigen keinen diagnostischen Nutzen bei der Differenzierung zwischen Kindern mit einer Schädelprellung und Kindern mit einem leichten SHT. S100B und NSE sind altersabhängige Marker.
8
CHAUDHARY, VISHAL. "DERIVATIVES RESEARCH PROJECT ON INDIAN STOCKS USING VOLATILITY SKEW STUDIES." Thesis, DELHI TECHNOLOGICAL UNIVERSITY, 2021. http://dspace.dtu.ac.in:8080/jspui/handle/repository/18396.
Abstract:
Exploiting stock volatility of equity derivatives to form a right strategy was the objective of
the internship at The Money Roller. Gathering historic data from the NSE’s website for 3
various stocks was the first step.
Data was collected from the NSE indices for all the 3 firms which included their historic call
and put options data for last 10 years. Then Implied Volatility (IV) for each underlying was
calculated for each year separately. This is named as the Historic-IV which is further used to
form a strategy.
Different techniques were employed to exploit the IV and strategies were formed accordingly.
All the data collected was back tested to ensure the strength of the strategy formed. With each
strategy the data was collected and prepared to use and was manipulated as per strategy’s
requirement. To ensure the accuracy of the strategy various conditions were set in place to
ensure the consistency of the results received in each case.
Excel-VBA was used as a main tool to run all the analysis and back testing.
9
Gong, Xiuqing. "PDMS based microfluidic chips and their application in material synthesis /." View abstract or full-text, 2009. http://library.ust.hk/cgi/db/thesis.pl?NSNT%202009%20GONG.
10
Xu, Wenjin. "Anomalous hall effect in ferromagnetic metallic thin films /." View abstract or full-text, 2010. http://library.ust.hk/cgi/db/thesis.pl?NSNT%202010%20XU.
11
Peng, Suili. "Nano/micro particle-based functional composites and applications /." View abstract or full-text, 2007. http://library.ust.hk/cgi/db/thesis.pl?NSNT%202007%20PENG.
12
Kam, Chuen. "Functional study of PICK1-ICA69 complex in the golgi apparatus /." View abstract or full-text, 2008. http://library.ust.hk/cgi/db/thesis.pl?NSNT%202008%20KAM.
13
Qiu, Yongfu. "Controlled growth and characterization of one-dimensional nano-structured materials /." View abstract or full-text, 2008. http://library.ust.hk/cgi/db/thesis.pl?NSNT%202008%20QIU.
14
Liu, Liyu. "Design and fabrication of microfluidic/microelectronic devices from nano particle based composites /." View abstract or full-text, 2008. http://library.ust.hk/cgi/db/thesis.pl?NSNT%202008%20LIU.
15
Qiu, Chunyin. "Phase slip fluctuations in low-dimensional superconductors : a numerical study using the string method /." View abstract or full-text, 2009. http://library.ust.hk/cgi/db/thesis.pl?NSNT%202009%20QIU.
16
Cheng, Chun. "Fabrication and characterization of one dimensional ZnO nanostructures /." View abstract or full-text, 2009. http://library.ust.hk/cgi/db/thesis.pl?NSNT%202009%20CHENG.
17
He, Xiaozhou. "Thermal dissipation field and its statistical properties in turbulent Rayleigh-Bénard convection /." View abstract or full-text, 2009. http://library.ust.hk/cgi/db/thesis.pl?NSNT%202009%20HE.
18
Fisher, Christine Marie. "Perceptions of Elementary School Children`s Parents Regarding Sexuality Education." University of Toledo / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1404314459.
19
Cortavarria, Erick, Francisco González, Akira Mejía, and Alberto Romani. "Lanzamiento de alimento para bebés dirigido al NSE C "Sanitos"." Universidad Peruana de Ciencias Aplicadas - UPC. Escuela de Postgrado, 2009. http://hdl.handle.net/10757/273874.
Abstract:
El presente documento desarrolla una propuesta de lanzamiento de una línea de productos de alimentación complementaria para bebés, con edades comprendidas entre los 6 y 12 meses de edad La línea de productos será lanzada por la empresa Alicorp Esta línea de productos tiene como grupo objetivo principal el NSE C, representados idealmente por Las Trabajadoras , nombre con el que el investigador peruano Rolando Arellano agrupa a personas de características similares en su libro Los Estilos de Vida en el Perú
20
Blanchi, Véronique. "Interet diagnostique de l'enolase neuron-specifique (nse) en pathologie pleuropulmonaire." Nice, 1988. http://www.theses.fr/1988NICE6510.
21
Idri, Amanda C. "Development of a Correlation Equation Between Shear Wave Values And NSPT Values in Northeastern Ohio." University of Akron / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=akron1574441753941474.
22
BARJAUD, PASCAL. "Etude d'un protocole d'utilisation dans la determination de la nse et du rapport nse/nne pour le suivi des cancers anaplasiques a petites cellules du poumon." Clermont-Ferrand 1, 1992. http://www.theses.fr/1992CLF13051.
23
Gruber, Christine. "Differentialdiagnose beim Lungenkarzinom durch CEA, CYFRA 21-1, NSE und ProGRP." Diss., lmu, 2008. http://nbn-resolving.de/urn:nbn:de:bvb:19-90260.
24
Fontenoy, Claudia, Maria Ines Ortiz, and Julio Santillana. "Relanzamiento y consolidación de la marca Trois en el NSE A." Master's thesis, Universidad Peruana de Ciencias Aplicadas (UPC), 2016. http://hdl.handle.net/10757/596581.
Abstract:
Relanzar una marca no es fácil, y más si se trata de una marca que pertenece a una empresa familiar, y que tiene como “hermana mayor” a Paula Cahen d´Anvers, marca argentina de ropa reconocida internacionalmente.
Indumentaria Perú S.A.C es una empresa familiar fundada hace 8 años por Malena Manzanares, Cecilia y Marcela Fontenoy; las dos últimas hermanas de una de los co autores de esta tesis. Ellas tres se asociaron para traer “Paula” al Perú, pero en esta nueva experiencia, se sintieron empoderadas para poder crear su propia marca: así nace Trois. Pero, conforme pasaba el tiempo, Trois empezó a tomar más relevancia y, de ser la marca secundaria, se convirtió en la marca que vende más del 60% de la tienda. Con esta información, saltan muchas preguntas y dudas cómo: ¿A qué marca le damos más importancia? ¿Cómo se llamará la tienda? ¿Cómo diferenciamos las marcas? Al ver a Trois rentable, ¿Cómo hacemos que la marca crezca? ¿A quién nos dirigimos?
Con todas estas preguntas empezamos la aventura de indagar sobre el mercado de la moda en el Perú – un mercado que es un verdadero boom - , profundizar en el conocimiento del target, averiguar los drivers de compra de las mujeres ejecutivas del NSE A, ver opciones de crecimiento, etc.
Al principio, pensamos en que la presente tesis se centraría en el desarrollo de nuevos canales para expandir la marca; pero, si hacíamos esto, estaríamos validando que los supuestos de la marca eran correctos, cuando no estábamos seguros de ello.
Lo importante también es entender las limitaciones y, aunque creamos fehacientemente que esta marca tiene mucho potencial de desarrollo, es importante que se pongan los pies sobre la tierra y entender que debemos avanzar poco a poco: primero consolidado la marca en la tienda propia de Miguel Dasso, conociendo los gustos de las clientas actuales, entender cómo les gusta comprar y con todo este background poder expandir la marca y hacerla crecer como sabemos que lo logrará.
Luego de los análisis e investigaciones que se desarrollan a lo largo de la presente tesis, pudimos observar que el proyecto de relanzamiento es totalmente viable y que generará una alta rentabilidad y margen en las socias de la marca.
25
Zboril, Sabrina. "Diagnóstico da síndrome da disfunção cognitiva em cães idosos após procedimento cirúrgico-anestésico." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/10/10137/tde-16092015-112158/.
Abstract:
A disfunção cognitiva é definida como alterações dos processos mentais e sua detecção é feita com auxílio de testes neuropsicológicos. Pesquisas vem sendo realizadas na tentativa de estabelecer prováveis marcadores neurobioquímicos precoces para estimar morte neuronal. O presente estudo avaliou 24 cães distribuídos em dois grupos: GC grupo controle (até 8 anos) (n=10) e GI grupo idoso (acima de 8 anos) (n=14). Todos os animais foram submetidos ao tratamento periodontal sob anestesia geral e avaliados previamente quanto à presença de outras doenças sistêmicas. Para tal foram submetidos a teste neurológico completo, exame cardiológico e à colheita de sangue venoso periférico para realização de hemograma completo, perfil renal e hepático. Os animais foram avaliados quanto a cognição com auxílio de duas escalas neuropsicológicas (ARCAD e CCDR) e à avaliação dos valores séricos das proteínas marcadoras de danos neuronais (NSE e S100β), nos períodos pré e pós-operatórios. Constatou-se aumento significativo da proteína S100β no GI em relação ao GC (p=0,014) no momento pré-operatório, e também entre os momentos pós-extubação nos animais do GC (p=0,04). Por meio das escalas comportamentais empregadas, não foi possível detectar a disfunção cognitiva no pós-cirúrgico de cães idosos submetidos a procedimento cirúrgico-anestésico. Os valores obtidos da proteína S100β sugerem que os animais idosos possuem possível neuroinflamação pré-operatória, ocasionada por inflamação sistêmica ou mesmo central; entretanto não foi possível correlacionar com as escalas comportamentais empregadasCognitive dysfunction is defined as changes in mental processes and it detection is performed with the aid of neuropsychological tests. Recently research has been conducted in attempt to establish early neuro biochemicals markers to estimate neuronal death. This study evaluated 24 dogs that were distributed into two groups: CG - control group (up to 8 years old) (n = 10) and EG - elderly group (over 8 years) (n = 14). All animals underwent periodontal treatment under general anesthesia and were previously evaluated to detect the presence of systemic diseases. A complete neurological and cardiac examination were performed in all animals and also a peripheral venous blood samples were collected for blood count, kidney and liver profile. The animals were assessed for cognition by using two neuropsychological scales (ARCAD and CCDR) and the assessment of serum levels of protein markers of neuronal damage (NSE and S100β) pre and postoperatively. A significant increase in S100β protein in EG compared to the CG (p = 0.014) in the preoperative period was observerd and also between the post-extubation times in the animals of CG (p = 0.04). Through behavioral scales used it was not possible to detect cognitive dysfunction in the postoperative elderly dogs underwent surgical - anesthetic procedure. The values of S100β protein suggest that elderly animals may have preoperative neuroinflammation caused by systemic or central inflammation; however we could not correlate with the behavioral scales
26
Sarras, Marcella. "Påverkan av hemolys vid analys av neuronspecifikt enolas på Cobas." Thesis, Malmö universitet, Fakulteten för hälsa och samhälle (HS), 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-44406.
Abstract:
Neuronspecifikt enolas (NSE) är en viktig biomarkör för att diagnostisera t.ex. neuroendokrina tumörer, särskilt småcellig lungcancer (SCLC) och neuroblastom. NSE används även som en del i utredning av hjärnskada vid hjärtstopp. Eftersom NSE finns i höga koncentrationer i erytrocyter, kan hemolys i blodprovet orsaka falskt förhöjda NSE-nivåer i serum utan hjärnskada. Syftet med studien var att utvärdera hur hemolys påverkar NSE-analysen på Cobas, ett helautomatiserat analysinstrument. Mätning av NSE-koncentration utfördes på Cobas 8000 från Roche Elecsys, baserad på immunokemisk sandwich-metod med ElectroChemi-LuminiscenceImmunoassay (ECLI) detektionsteknik. För att studera hemolysens inverkan, tillverkades hemolysat från 20 patientprover. Dessa hemolysat tillsattes till poolat serum, med NSE-nivåer inom referensintervallet (< 17 µg/L). Även graden av hemolys bestämdes på Cobas 8000. Resultatet visade ett linjärt samband mellan de uppmäta hemolysindex (HI) värden och S-NSE värden. Variationen i NSE-tillskott på individnivå undersöktes och resulterade i slutsatsen att varje hemolysenhet motsvarar ett NSE-tillskott på 0,33 ± 0,07 µg/L som frigörs från erytrocyter. Ett förslag för att lösa problemet med hemolys vid analys av S-NSE är att använda en kompenserande faktor för att korrigera NSE-koncentrationen. Kompensering kan utföras med hjälp av det erhållna sambandet i studien (1 HI = 0,33 ± 0,07 µg/L NSE-tillskott) genom att subtrahera tillskottet från den uppmätta NSE-koncentrationen.Neuron Specific Enolase (NSE) is an important biomarker for diagnosing e.g. neuroendocrine tumors, especially small cell lung cancer (SCLC) and neuroblastoma. NSE is also used as a part of the investigation of brain damage in cardiac arrest. Because NSE is present in high concentrations in erythrocytes, hemolysis in the blood sample can cause falsely elevated NSE levels in serum without brain damage. The purpose of this study was to evaluate how hemolysis affects NSE analysis on Cobas, a fully automated analytical instrument. Measurement of NSE concentration was performed on Cobas 8000 from Roche Elecsys, based on immunochemical sandwich method with ElectroChemi-Luminescence Immunoassay (ECLI) detection technique. To study the effect of hemolysis, hemolysates were prepared from 20 patient samples. These hemolysates were added to pooled serum, with NSE levels within the reference range (<17 μg/L). The degree of hemolysis was also determined on Cobas 8000. The result showed a linear relationship between the measured hemolysis index (HI) values and S-NSE values. The variation in NSE contribution at the individual level was examined with the result that each hemolysis unit corresponds to an NSE contribution of 0.33 ± 0.07 µg/L, which is released from erythrocytes. A suggestion to solve the problem of hemolysis relating to NSE analysis is to use a compensatory factor to correct the NSE concentration. Compensation can be performed by using the relationship obtained in the study (1 HI = 0.33 ± 0.07 µg/L NSE contribution) and subtracting the contribution from the measured NSE concentration.
27
Diaz, Smoje Mariana Andrea [Verfasser], and George [Gutachter] Coupland. "Functional characterization of NSE4 paralogs in Arabidopsis thaliana / Mariana Andrea Diaz Smoje ; Gutachter: George Coupland." Köln : Universitäts- und Stadtbibliothek Köln, 2018. http://d-nb.info/1160379386/34.
28
Small, Lauren. "An investigation into the function of the SUMOylation of Nse2 and PCNA in S. pombe." Thesis, University of Sussex, 2014. http://sro.sussex.ac.uk/id/eprint/52751/.
Abstract:
Small ubiquitin like modifier (SUMO) is post-translationally attached to target proteins, forming a covalent bond between its C-terminal glycine and one or more lysine residues on the target protein. SUMO modification of target proteins can affect protein-protein interactions, protein activity, localistation and stability. This study set out to develop an efficient in vitro SUMOylation system to enable the identification of target lysine residues in S. pombe proteins by mass spectrometry. This involved incorporating a trypsin cleavage site adjacent to the SUMO di-glycine motif to improve peptide coverage during mass spectrometry. Several SUMOylated target proteins were identified here, including the E2 SUMO conjugating enzyme Hus5, the E3 SUMO ligase Nse2 and PCNA. The second part of this study focused on the characterisation of unSUMOylatable E3 SUMO ligase nse2 mutants. Integration of lysine to arginine mutations into the genome did not result in any mutant phenotypes and a function for auto-SUMOylation of Nse2 was not identified. During this study, human patients with mutations in the nse2 gene were reported and the equivalent mutations were integrated into the S. pombe nse2 gene to investigate the effect of the mutations. The final part of this work involved the analysis of the SUMOylation of S. pombe PCNA. Using the in vitro system, four target lysine residues for SUMO were identified. SUMOylation of PCNA was also observed in vivo following pull-down studies and 2D gel analysis of wild type and unSUMOylatable mutants. Extensive epistasis analysis was undertaken using these mutants to investigate the role of SUMOylation of S. pombe PCNA.
29
Romero, Meza Verónica Patricia. "Sensibilidad materna y problemas de conducta en niños preescolares de NSE bajo." Bachelor's thesis, Pontificia Universidad Católica del Perú, 2016. http://tesis.pucp.edu.pe/repositorio/handle/123456789/7481.
Abstract:
Tanto Ainsworth como Bowlby plantearon que la sensibilidad materna es un factor que se asocia al desarrollo de un apego seguro en el niño, lo cual ha sido respaldado por diversos estudios a lo largo del tiempo. De esta manera, el niño que posea un apego seguro tendría menos posibilidades de desarrollar problemas de conducta a lo largo de su vida. De esta manera, el presente estudio tiene como objetivo evaluar la relación entre la sensibilidad materna y los problemas de conducta en preescolares de nivel socioeconómico bajo de Lima Metropolitana. Para ello se evaluó a 36 niños(as) con un rango de edad de 36 a 59 meses (M = 44.31, DE = 7.09) junto a sus madres con edades entre 22 y 42 años de edad (M = 28.33, DE = 5.14). Asimismo, para evaluar la sensibilidad materna se utilizó el Maternal Behavior for Preschooler´s Q-set (MBPQS) (Posada, Kaloustian, Richmond & Moreno, 2007) y para los problemas de conducta el Child Behavior Check List 1.5- 5 (CBCL 1.5- 5) (Rescorla, 2005; ASEBA, 2014). Los resultados muestran que no existe una relación entre la sensibilidad materna y los problemas de conducta en el niño(a). Asimismo, se encontró una diferencia significativa en los problemas de conducta global en relación al sexo del niño, es decir, los varones tienden a presentar mayores problemas de conducta. Además, en cuanto a la escala externalizante se evidenció que los varones presentan más tendencia a desarrollar problemas de este tipo que las niñas, no mostrando ninguna diferencia significativa en la escala internalizante.Ainsworth and Bowlby raised that maternal sensitivity is a factor associated with the development of a secure attachment in the child, has been supported by several studies over time. In this way, the child, with a secure attachment, would be less likely to develop behavioral problems throughout his life. The present study aims to explore the relationship between maternal sensitivity and behavior problems in preschool children of low socioeconomic status belonging to Lima Metropolitana. In order to achieve this, 36 children with ages in a range of 36 to 59 months (M = 44.31 , SD = 7.09) were evaluated, as well as their mothers, whose age oscillated between 22 and 42 years (M = 28.33 , SD = 5.14). Also, to evaluate maternal sensitivity was used the Maternal Behavior for Preschooler´s Q-set (MBPQS) (Posada, Kaloustian, Richmond & Moreno, 2007) and for behavior problems the Child Behavior Check List 1.5- 5 (CBCL 1.5- 5) (Rescorla, 2005; ASEBA, 2014). The results show there were not significant relation between maternal sensitivity and behavior problems in the child. Likewise, we found one significant difference in global behavior problems in relation to the sex of the child, where boys tend to have greater problems of conduct than girls. Moreover, the externalizing scale was shown that boys are more likely to develop this kind of problems than girls, showing no significant difference in internalizing scale.
Tesis
30
Toledo, Flavia Dutra de. "Biomarcadores de lesão cerebral em pacientes idosos submetidos à anestesia subaracnoidea para tratamento de fraturas de fêmur." Universidade Estadual Paulista (UNESP), 2018. http://hdl.handle.net/11449/157335.
Abstract:
Submitted by FLAVIA DUTRA DE TOLEDO (flavia.dutra@unesp.br) on 2018-10-16T12:49:00Z
No. of bitstreams: 1
TOLEDO_FLAVIA_DUTRA_TESE.pdf: 1343341 bytes, checksum: 04c961b0d4c2c7913f24f0ef86d634f4 (MD5)Approved for entry into archive by ROSANGELA APARECIDA LOBO null (rosangelalobo@btu.unesp.br) on 2018-10-17T14:19:04Z (GMT) No. of bitstreams: 1 toledo_fd_dr_bot.pdf: 1343341 bytes, checksum: 04c961b0d4c2c7913f24f0ef86d634f4 (MD5)
Made available in DSpace on 2018-10-17T14:19:04Z (GMT). No. of bitstreams: 1 toledo_fd_dr_bot.pdf: 1343341 bytes, checksum: 04c961b0d4c2c7913f24f0ef86d634f4 (MD5) Previous issue date: 2018-08-24
Introdução: A última atualização demográfica do Instituto Brasileiro de Geografia e Estatística realizada em 2017 mostrou que a população acima de 60 anos representava 14,6% dos 207,1 milhões de habitantes do Brasil, o que corresponde a aproximadamente 30 milhões de idosos, com expectativa de vida de 75,8 anos. Entre 2007 e 2011, o número acumulado de internações por fraturas de fêmur em pacientes acima de 60 anos, nos hospitais do Sistema Único de Saúde, foi de 175.781 O delirium pós-operatório é uma complicação comum nos pacientes idosos, e está associado a hospitalizações prolongadas, maiores taxas de institucionalização após a alta, deterioração cognitiva prolongada, diminuição da capacidade funcional, além de ser fator independente de mortalidade em 6-12 meses. Estudo disponível na literatura mostra que 14 a 24% dos pacientes idosos com fratura de quadril apresentam delirium já na admissão hospitalar, sendo que a prevalência durante a internação chega a 56%. Os mecanismos fisiopatológicos do desenvolvimento do delirium pós-operatório (DPO) e do déficit cognitivo pós-operatório têm sido estudados em nível molecular, porém ainda com pouco ganho. Maiores esforços de pesquisa são colocados na identificação de biomarcadores diagnósticos e prognósticos que estejam relacionados com mecanismos moleculares que levam ao DPO. Objetivos: Primariamente, relacionar os níveis séricos de dois biomarcadores de neuroinflamação (S100B e enolase neurônio-específica) com a ocorrência de delirium pré e pós-operatório em pacientes idosos submetidos a cirurgias de correção de fratura de quadril (fêmur proximal). Como objetivo secundário, foi proposto avaliar a influência dos fatores sexo, hipotensão perioperatória, classificação de risco anestésico ASA, uso de fármacos anestésicos para sedação (midazolam e fentanil), além de duração e tipo de cirurgia realizada (artroplastia de quadril ou osteossíntese de fêmur) sobre os níveis dos biomarcadores. Métodos: Foi realizado estudo clínico observacional prospectivo com pacientes acima de 60 anos internados no HCFMB para correção de fratura de quadril (terço proximal do fêmur) no período de maio de 2017 a abril de 2018; todos os pacientes assinaram o Termo de Consentimento Livre e Esclarecido. Os pacientes foram avaliados em dois momentos: dentro das 24 horas que antecederam a cirurgia (M1) e, novamente, 24 horas após o final da cirurgia (M2). Em cada momento, foi realizado o diagnóstico de presença ou ausência de delirium por meio da escala CAM (Confusion Assessment Method), instrumento validado em Português, e foram coletadas amostras de sangue para dosagem de S100B e Enolase plasmáticos. As dosagens dos biomarcadores foram realizadas por método ELISA. Resultados: Dos 42 pacientes analisados, 33 eram do sexo feminino e 9 do sexo masculino (78,57% e 21,4%, respectivamente), com idade média de 71,97 ± 8,68 anos. Delirium ocorreu em 11,9% dos pacientes em M1 e 16,7% em M2. Não houve variação dos níveis médios de S100B entre pacientes com e sem delirium, nem dentro do mesmo momento, quanto de um momento para outro (p=0,12). Os valores médios de NSE foram estatisticamente diferentes quando comparados os pacientes sem delirium pré-operatório e aqueles com delirium pós-operatório (p=0,002); entretanto, pacientes que não tiveram delirium em qualquer momento também apresentaram variação significante do marcador entre M1 e M2 (p=0,004). Ainda, pacientes com delirium pós-operatório tiveram níveis mais altos de NSE dosados em M2 (p=0,02). Mulheres apresentaram maiores níveis de S100B (p=0,03), enquanto as médias de NSE foram maiores entre homens (p=0,04). Não houve influência da classificação ASA tanto nos níveis de S100B quanto de NSE (p=0,67 e p=0,12, respectivamente). Níveis mais altos de S100B foram verificados em pacientes que apresentaram algum episódio de hipotensão perioperatória (p=0,035), porém não houve relação entre este último evento e a ocorrência de delirium pós-operatório (p=0,65). Quanto ao uso de sedação intraoperatória, doses maiores de midazolam foram administradas aos pacientes que não desenvolveram DPO (p=0,001), enquanto as doses de fentanil não diferiram entre pacientes com e sem DPO (p=0,21). Não houve relação entre o tipo de procedimento cirúrgico executado e duração média da cirurgia (p=0,89 e p=0,15, respectivamente) com a ocorrência de DPO. Conclusões: Não foi encontrada associação entres os níveis do marcador S100B e a presença de delirium em qualquer momento; entretanto, níveis pré-operatórios aumentados de NSE foram relacionados à ocorrência de delirium pós-operatório. Pacientes com episódios de hipotensão perioperatória apresentaram níveis mais altos de S100B na avaliação pós-operatória. São necessárias investigações futuras quanto ao nível de expressão destas proteínas por outros tecidos e se existem outras vias de sinalização celular ainda desconhecidas, para que assim possamos entender melhor o comportamento destes biomarcadores e a sua relação com a patogênese do delirium.
Background: According to the latest census from IBGE (Instituto Brasileiro de Geografia e Estatística), population over 60 years-old accounted for 14,3% of a total 204,9 million habitants in Brazil. From 2007 to 2011, 175.781 elder patients were admitted after a hip fracture in brazilian public hospitals. Post-operative delirium (POD) is an usual complication in the elderly and is associated to longer hospital stay, cognitive impairment, functional decline and increased 6-12 months mortality rate. Delirium rates between the elder population can be as high as 14 to 24% already at admission, being the prevalence as high as 56% during hospital stay. Pathophysiologic mechanisms of delirium have been studied at molecular level, but research efforts are still needed in order to develop sensitive and specific early markers for this condition, so that diagnosis and effective treatment would be readily given. Objectives: This research project aims to correlate two neuroinflamation biomarkers serum levels (S100B protein and Neuron Specific Enolase - NSE) and the incidence of pre and postoperative delirium in elderly patients undergoing hip fracture repair. Also, we intent to evaluate how gender, ASA Physical Status classification and perioperative hypotension may contribute to changes in the levels of these biomarkers. Methods: An observational prospective study was proposed envolving patients aged 60 or more who were admitted at Clinics Hospital of Botucatu Medical School (Botucatu, São Paulo, Brazil) for hip fracture repair, from May, 2017 to April, 2018. All patients signed the Informed Consent. The CAM (Confusion Assessment Method) short scale was used to assess the presence of delirium first at admission and again, 24 hours after surgery. Blood samples were also collected at two moments, by the patient’s admission to the operating room and then 24 hours after surgery, to assess NSE and S100B plasmatic levels. S100B and NSE levels were measured on the Synergy HT Biotec analyzer using ELISA technique (Elabscience ® kits). Results: Of 42 patients included, 33 were female and 9 male (78.57% vs 21.4%), with mean age of 71.97 ± SD 8.68 years). Delirium occurred in 11.9% of patients at M1 and 16.7% at M2. S100B mean levels did not significantly change between patients with and without delirium, neither at the same moment (p=0.95 and p=0.96, respectively) nor from M1 to M2 (p=0,12). NSE levels in delirious and non-delirious patients at M1 were elevated at M2 (p=0.04); however, higher NSE levels at M1 were significantly related to emergence of delirium at M2 (p=0.002). Moreover, despite of the fact that NSE levels increased at M2 in patients without delirium (p=0.004), delirious patients at M2 had significantly higher NSE levels (p=0.02). S100B levels were higher in female patients (p=0.03), whereas NSE was higher in male ones (p=0.04). Perioperative hypotension was linked to higher S100B levels at M2 (p=0.035), but not to postoperative delirium 9p=0,65). ASA classification had no influence on biomarkers levels. Regarding the use of intraoperative sedation, higher amounts of midazolam were administered to patients who did not further develop POD (p=0.001); fentanyl doses did not differ between patients with or without POD (p=0.21). Surgical technique (hip replacement or osteosynthesis) and surgery duration had no influence on POD occurrence (p=0.89 and p=0.15, respectively). Conclusions: No association was found between S100B levels and delirium, but increased preoperative NSE levels were related to emergence of postoperative delirium. Patients with records showing episodes of perioperative hypotension had higher postoperative levels of S100B. Further investigation of yet unidentified tissue expression and signaling pathways of these proteins are needed in order for them to be used as predictors of delirium in clinical practice.
31
Skilton, Andrew Michael. "Investigation of SUMO phosphorylation and analysis of selected targets of the two sumo ligases NSE2 and PLI1." Thesis, University of Sussex, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.496854.
Abstract:
SUMO (Small Ubiquitin-like Modifier) is a post-translational modifier, which is conjugated to its targets through a pathway analogous to that of ubiquitinylation. SUMO is implicated in a variety of cellular processes that have consequences for the repair of DNA damage and cell cycle progression. This is reflected in the fact that S. pombe cells, mutant for the SUMO conjugation pathway, are sensitive to genotoxins and have aberrant cellular morphologies and defects in DNA segregation.
32
Zelkowski, Mateusz [Verfasser]. "Arabidopsis NSE4 proteins act in somatic nuclei and meiosis to ensure plant viability and fertility / Mateusz Zelkowski." Halle, 2019. http://d-nb.info/117779859X/34.
33
Apostolova, Sonia. "The RING domain of Nse1: roles in Smc5/6 complex stability and genome integrity in human cells." Doctoral thesis, Universitat de Lleida, 2021. http://hdl.handle.net/10803/672395.
Abstract:
El complex Smc5/6, és un dels tres complexos de manteniment de l’estructura dels cromosomes (Structural Maintenance of Chromosomes, SMC). En aquest treball de tesi es mostra que el domini RING de la subunitat Nse1 del complex Smc5/6, té un paper crucial en el manteniment de l’estabilitat genòmica en cèl·lules humanes. Mitjançant CRISPR-Cas9 hem creat mutants estables de NSE1 en el domini RING C-terminal en cèl·lules HEK293T. En aquests mutants no es detecta la proteïna Nse1, ni altres subunitats del complex. A més, presenten un fenotip d’inestabilitat genòmica, caracteritzat per un creixement lent, mitosis més prolongades en el temps, dany endogen en el DNA, un alentiment en la progressió de les forquilles de replicació i sensibilitat a l’agent genotòxic MMS. Els nostres resultats suggereixen que els mutants en NSE1 entren en mitosis amb la presència de zones del DNA no replicades o amb estructures de recombinació no resoltes, que porten al trencament de cromosomes i a inestabilitat genòmica en la següent generació.El complejo Smc5/6, es uno de los tres complejos de mantenimiento de la estructura de los cromosomas (Structural Maintenance of Chromosomes, SMC). En esta tesis se muestra que el dominio RING de la subunidad Nse1 del complejo Smc5/6, tiene un papel crucial en el mantenimiento de la estabilidad genómica en células humanas. Mediante CRISPR-Cas9 hemos creado mutantes estables de NSE1 en el dominio RING C-terminal, en células HEK293T. En estos mutantes no se detecta la proteína Nse1, ni otras subunidades del complejo. Además, presentan un fenotipo de inestabilidad genómica, caracterizado por un crecimiento lento, mitosis más prolongadas, daño endógeno en el ADN, ralentización en la progresión de las horquillas de replicación y sensibilidad a el agente genotóxico MMS. Estos resultados sugieren que los mutantes en NSE1 entran en mitosis con la presencia de zonas del DNA no replicadas o con estructuras de recombinación no resueltas, que llevan a la rotura de cromosomas y a inestabilidad genómica en la siguiente generación.
The Smc5/6 complex is one of the three Structural Maintenance of Chromosomes (SMC) complexes. This thesis shows that the RING domain of the Nse1 subunit of the Smc5/6 complex plays a crucial role in maintaining genomic stability in human cells. Using CRISPR-Cas9 we created stable mutants of NSE1 in the C-terminal RING domain, in HEK293T cells. Nse1 protein and other subunits of the complex are not detected in these mutants. In addition, they present a phenotype of genomic instability, characterized by slow growth, prolonged mitosis, endogenous DNA damage, slowing in the progression of replication forks and sensitivity to the genotoxic agent MMS. These results suggest that mutants in NSE1 enter mitosis with the presence of unreplicated DNA regions or with unresolved recombination structures, leading to chromosome breakage and genomic instability, in the next generation.
34
Zhang, Zhihan. "NSEA: n-Node Subnetwork Enumeration Algorithm Identifies Lower Grade Glioma Subtypes with Altered Subnetworks and Distinct Prognostics." Case Western Reserve University School of Graduate Studies / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=case148595901371196.
35
Stoll, Alexander. "Neurologische Komplikationen nach Herzoperationen unter der Berücksichtigung der Hypoxiemarker NSE und Protein S100 /." Hamburg : Akademos Wiss.-Verl, 2003. http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&doc_number=010456703&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA.
36
Mossberg, Zimon. "Achieving Automatic Speech Recognition for Swedish using the Kaldi toolkit." Thesis, KTH, Skolan för datavetenskap och kommunikation (CSC), 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-194178.
Abstract:
The meager offering of online commercial Swedish Automatic Speech Recognition ser-vices prompts the effort to develop a speech recognizer for Swedish using the open sourcetoolkit Kaldi and publicly available NST speech corpus. Using a previous Kaldi recipeseveral GMM-HMM models are trained and evaluated against commercial options toallow for reasoning of the performance of a customized solution for Automatic SpeechRecognition to that of commercial services. The evaluation takes both accuracy andcomputational speed into consideration. Initial results of the evaluation indicate a sys-tematic bias in the selected test set confirmed by a follow up investigative evaluation.The conclusion is that building a speech recognizer for Swedish using the NST corpusand Kaldi without expert knowledge is feasible but requires further work.En taligenkännare för svenska utvecklas med målet att utvärdera hur en taligenkännareutvecklad med fritt tillgängliga verktyg står sig mot kommersiella taligenkänningstjänster.Verktyget som används är det öppna källkodsverktyget Kaldi och som träningsdataanvänds det offentligt tillgängliga talkorpuset för svenska från NST. De framtagna mod-ellerna jämförs mot kommersielt tillgängliga tjänster för taligenkänning på svenska.Tidiga resultat i jämförelsen indikerar ett systemiskt jäv i den valda testdata, vilketbekräftas av en uppföljande undersökande utvärdering. Slutsatsen av arbetet är attutsikterna att ta fram en taligenkännare för svenska är goda men kräver omfattandearbete.
37
Rojas, Parco Frank Gabriel, and Ortiz Jhow Mckevin Zamora. "Correlación de los valores Nspt con Ndpl en los suelos arenosos de la Asociación Agropecuaria Sumac Pacha - Lurin." Bachelor's thesis, Universidad Ricardo Palma, 2015. http://cybertesis.urp.edu.pe/handle/urp/1252.
Abstract:
El presente trabajo de tesis, trata sobre las correlaciones de 2 diferentes equipos de penetración, en los suelos arenosos de la Asociación Agropecuaria Sumac Pacha ubicado en el distrito de Lurín, a fin de establecer ecuaciones de correlación entre ellas.
Para el desarrollo de la presente investigación, cuyo objeto es correlacionar el número de golpes del ensayo SPT con el número de golpes DPL. Para ello se realizaron los ensayos de campo en un terreno Arenoso de 25x40m (1000 m2) de la Asociación Agropecuaria Sumac Pacha, ubicado en el distrito de Lurín.
El ensayo SPT, es un ensayo de campo estandarizado que sirve para la determinación de la resistencia a la penetración del suelo y que se realiza dentro de una perforación, desde la superficie del terreno y con una profundidad y penetración definida. El ensayo DPL es un ensayo de campo para la determinación de la resistencia a la penetración del suelo. Se realiza el ensayo en terrenos arenosos con profundidades de hasta 8m.
Se realizó un estudio tipo no experimental transversal, que se llevaron a cabo en un depósito arenoso con poca presencia de finos. Se realizaron las caracterizaciones correspondientes por medio de ensayos de granulometría, Límites de Attemberg, Corte Directo, Humedad natural, Densidad natural.
Los Ensayos de Penetración se hicieron en suelos con características SP y SM en su mayoría, y de alto estado de densidad que varía de 1.483gr/cm3 hasta 2.182gr/cm3.
Los resultados obtenidos sobre la correlación entre los valores NSPT y NDPLfueron 2 ecuaciones que fueron hallados por diferentes métodos estadísticos. Concluye que las correlaciones obtenidas serán válidas hasta los 1.80 m de profundidad; siendo las ecuaciones de correlación únicas y exclusivas para la zona de estudio (Terreno de 1000m2 dentro de la Asociación Agropecuaria Sumac Pacha) de donde se puede deducir que el número de golpes NSPT y NDPL son directamente proporcionales.
This thesis, deals with two different tools correlations penetration in the sandy soils of the Agricultural Association Sumac Pacha located in the district of LurÍn, in order to establish correlation equations between them.
For the development of this research, which principal trial is to correlate the number of strokes of the SPT with the number of strokes DPL. To do field trials were conducted on sandy ground of 25x40m (1000 m2) of the Agricultural Association Sumac Pacha, located in the district of LurÍn.
The SPT is a standardized test field serving for the determination of resistance to soil penetration and is performed within a borehole from the earth surface and a defined penetration depth. The DPL assay is a field for determining the resistance to penetration of the soil. The trial in sandy soils with depths of up to 8m is performed.
A transverse non-experimental study, which was conducted in a sandy deposit with little presence of fines was performed. The corresponding characterizations by tests of grain, Attemberg limits, Straight Cut, natural humidity, natural density were performed.
Penetration tests were done in soil characteristics SP and SM mostly state and high density ranging from 1.483gr / cm3 to 2.182gr / cm3.
The results on the correlation between NSPT and NDPL values were two equations were found by various statistical methods. It concludes that the correlations obtained are valid until 1.80 m depth; equations being unique and exclusive correlation for the study area (1000m2 land within the Agricultural Association Sumac Pacha) where it can be deduced that the number of strokes and NDPL NSPT are directly proportional.
38
Gönner, Svenja Lara [Verfasser]. "Charakteristika und Outcome nach Implantation bioresorbierbarer Scaffolds bei Patienten mit NSTE-ACE nach 3 Jahren / Svenja Lara Gönner." Mainz : Universitätsbibliothek der Johannes Gutenberg-Universität Mainz, 2021. http://d-nb.info/1238223869/34.
39
Alfaro, Prieto Gladys Consuelo. "Sensibilidad materna y apoyo social percibido en madres de niños preescolares de NSE bajo." Bachelor's thesis, Pontificia Universidad Católica del Perú, 2017. http://tesis.pucp.edu.pe/repositorio/handle/123456789/9386.
Abstract:
La investigación tuvo como finalidad conocer la relación entre sensibilidad materna y el apoyo social
percibido por madres de niños/as preescolares de nivel socioeconómico bajo. Para ello, participaron 29
madres entre 23 y 44 años (M = 29.57, DE = 5.65), cuyos hijos/as tenían entre 49 y 73 meses de edad
(M = 57, DE = 6.87). Se utilizó el Maternal Behavior for Preschoolers’ Q-Set (Posada, Moreno, &
Richmond, 1998) en modalidad de observación y el Cuestionario de Desenlaces Médicos de Apoyo
Social (Sherbourne & Stewart, 1991) validado en español por Rodríguez y Enrique (2007). Los
resultados mostraron una asociación significativa y positiva de mediana magnitud entre el apoyo social
de tipo instrumental y el nivel global de sensibilidad materna, así también con las escalas de supervisión
y monitoreo, y apoyo de base segura. Se tuvo como objetivo específico describir la sensibilidad
materna, obteniéndose un bajo nivel en sus puntuaciones, así como una correlación negativa de
significancia marginal con la edad de la madre. Respecto al segundo objetivo específico, se describió
el apoyo social y se identificó que el apoyo instrumental se percibe en menor medida que los otros tipos
de soporte, además de hallar diferencias en el nivel de apoyo según la estructura familiar de la madre.
Estos hallazgos revelan que en contextos de pobreza, a medida que las cuidadoras perciben asistencia
conductual y material tanto en el cuidado de su hijo/a preescolar como en sus labores cotidianas, ellas
tienden a mostrarse más sensibles en la crianza.The research aims at exploring the relationship between maternal sensitivity and perceived social support in mothers of pre-school children of low socioeconomic status. Twenty-nine mothers between the ages of 23 and 44 (M = 29.57, SD = 5.65), whose children were between 49 and 73 months of age (M = 57, SD = 6.87). This study used the Maternal Behavior for Preschoolers' Q-Set (Posada, Moreno, & Richmond, 1998) in observation mode, and the Social Support Medical Outcomes Questionnaire (Sherbourne & Stewart, 1991) validated in Spanish by Rodríguez and Enrique (2007). The results showed a significant and positive association of medium magnitude between instrumental type social support and the overall level of maternal sensitivity, as well as with the scale supervision and monitoring and safe base support. A specific objective was to describe maternal sensitivity, which was found a low level in her grades, as well as a negative correlation of marginal significance with the mother's age. Regarding the second specific objective, the social support was described and it was identified that the instrumental support is the one that is perceived in a smaller proportion than the other types of support, besides finding differences in the level of support according to the family structure of the mother. These findings indicate that in contexts of poverty, as mothers perceive behavioral and material assistance in the care of their preschool child and in their daily tasks, they tend to be more sensitive in parenting.
Tesis
40
Quantin, Xavier. "Intérêt pronostic de la NSE sérique pour le cancer bronchique non à petites cellules." Montpellier 1, 1995. http://www.theses.fr/1995MON11020.
41
Diyaolu, Olamilekan Olawale. "Workers’ compensation insurance and IFRS17 non-similar to life techniques with focus on risk adjustment." Master's thesis, Instituto Superior de Economia e Gestão, 2021. http://hdl.handle.net/10400.5/22776.
Abstract:
Mestrado Bolonha em Actuarial ScienceThe need for global comparability, recognition, measurement, presentation, and disclosure of insurance contracts gave birth to IFRS17. IFRS17 marks a new era for insurance contract accounting. This work brings forward the impact of IFRS17 on the Workers Compensation line of business (WC LoB). Liabilities in the WC LoB can be of a very different nature, namely workers compensatio insurance using non-similar to life techniques and annuities originating from non-life insurance contracts and relating to health insurance obligations that use similar to life techniques (SLT). The main focus of this paper will be on the non-similar life technique as this is the very specificity of the Portuguese insurance market. The report will present the basic measurement approaches with more focus on the Premium Allocation Approach (PAA) under the standard. The structure of the report resumes the analysis of the impact of IFRS17 on Workers Compensation by considering the disaggregation into non-similar and similar to life techniques i.e., claims arising from the WC LoB are divided into two types. The Addactis IBNRS software will be used in the analysis of this report. This is dedicated software for the non-life type of claims reserving.
info:eu-repo/semantics/publishedVersion
42
Elias, Bruno Cesar. "Comparação dos valores séricos de enolase neuronal específica (NSE) em cães com e sem encefalite." Universidade Estadual de Londrina. Centro de Ciências Agrárias. Programa de Pós-Graduação em Ciência Animal, 2016. http://www.bibliotecadigital.uel.br/document/?code=vtls000205310.
Abstract:
Biomarcadores são utilizados na medicina humana e veterinária com intuito de auxiliar as condutas clínicas. A enolase neuronal específica (neuronal especific enolase - NSE) é um biomarcador de citólise neuronal, que possui estabilidade em fluídos extracelulares, como sangue e líquido cerebroespinhal. Em pesquisas clínicas com humanos, foi observada confiabilidade em amostras séricas para diferenciar e estimar danos no sistema nervoso central em casos de encefalite. Na medicina veterinária, não foram encontrados estudos avaliando a expressão da NSE em amostras séricas de cães com encefalite. Deste modo, os objetivos desse estudo foram comparar os valores da NSE sérica em cães com e sem encefalite e avaliar a eficácia do teste de ELISA na detecção do biomarcador. Para isso, foram utilizados no total 38 cães, distribuídos em dois grupos, sendo 19 cães com encefalite (GE) e 19 cães sem encefalite (GS). Os critérios para inclusão para o GS foram: idade entre 1 e 7 anos, com exames clínico e laboratoriais normais. Para o GE os critérios de inclusão foram: cães com sinais neurológicos encefálicos, diagnóstico molecular positivo para cinomose, e ausência de sinais de hemólise. Quanto aos resultados obtidos verificou-se que para o GE os valores séricos de NSE mais elevados, com maior variação, e média e mediana superiores ao GS, havendo diferença significativa entre os grupos (p = 0,0053). A NSE pode ser mensurada nas amostras séricas testadas, demonstrando a viabilidade do teste de ELISA utilizando anticorpos humanos. Conclusão: foram detectados valores elevados de NSE em cães com encefalite quando comparados com os cães sem encefalite, e que o teste de ELISA pode ser usado para mensurar a NSE em amostras de soro de cães, e, contribuindo para a validação de NSE sérica como um biomarcador para auxiliar na avaliação de cães com encefalite.The use of biomarkers in human and veterinary medicine is important to help the clinical management. Regarding to this, the specific neuronal enolase (NSE) is a biomarker resultant of the neuronal cell lysis, which demonstrate stability in extracellular fluids such as blood and cerebrospinal fluid. In human clinical researchs, was observed reliability in serum samples to distinguish and estimate the central nervous system damage in cases of encephalitis. In veterinary medicine, there are no studies evaluating the expression of NSE in serum samples from dogs with encephalitis. Thus, the objectives of this study was to compare the values of serum NSE in healty dogs and dogs with encephalitis and to evaluate theefficacy of the ELISA test using human antibodies in the detection of biomarker. For this, we used 38 dogs in total, divided into two groups, 19 dogs with encephalitis (GE) and 19 dogs without encephalitis (GS). The criteria for inclusion in to the GS were aged 1 to 7 years, with normal clinical and laboratory tests. For the GE inclusion, criteria were dogs with neurological signs brain injury, positive molecular diagnosis for distemper, and no signs of hemolysis. Regarding the results obtained it was found that for the GE serum NSE values higher with greater variation, and higher mean and median GS, there was a significant difference between the groups (p = 0.0053). In the serum samples tested, the NSE was effectivelly measured, demonstrating the feasibility of ELISA ?using human antibodies. Conclusions: in dogs with encephalitis the NSE values werer higher when compared to dogs without encephalitis, presenting a significant difference between the groups and contributing to the validation of serum NSE as a biomarker; the ELISA test can be used to measure the NSE in serum samples of dogs.
43
Neri, Pierre. "Use of GNSS signals and their augmentations for Civil Aviation navigation during Approaches with Vertical Guidance and Precision Approaches." Thesis, Toulouse, INPT, 2011. http://www.theses.fr/2011INPT0073/document.
Abstract:
La navigation par satellite, Global Navigation Satellite System, a été reconnue comme une solution prometteuse afin de fournir des services de navigation aux utilisateurs de l'Aviation Civile. Ces dernières années, le GNSS est devenu l'un des moyens de navigation de référence, son principal avantage étant sa couverture mondiale. Cette tendance globale est visible à bord des avions civils puisqu'une majorité d'entre eux est désormais équipée de récepteurs GNSS. Cependant, les exigences de l'Aviation Civile sont suffisamment rigoureuses et contraignantes en termes de précision de continuité, de disponibilité et d'intégrité pour que les récepteurs GPS seuls ne puissent être utilisés comme unique moyen de navigation. Cette réalité a mené à la définition de plusieurs architectures visant à augmenter les constellations GNSS. Nous pouvons distinguer les SBAS (Satellite Based Augmentation Systems), les GBAS (Ground Based Augmentation Systems), et les ABAS (Aircraft Based Augmentation Systems). Cette thèse étudie le comportement de l'erreur de position en sortie d'architectures de récepteur qui ont été identifiées comme étant très prometteuses pour les applications liées à l'Aviation CivileSince many years, civil aviation has identified GNSS as an attractive mean to provide navigation services for every phase of flight due to its wide coverage area. However, to do so, GNSS has to meet relevant requirements in terms of accuracy, integrity, availability and continuity. To achieve this performance, augmentation systems have been developed to correct the GNSS signals and to monitor the quality of the received Signal-In-Space (SIS). We can distinguish GBAS (Ground Based Augmentation Systems), ABAS (Airborne Based Augmentation Systems) SBAS (Satellite Based Augmentation Systems). In this context, the aim of this study is to characterize and evaluate the GNSS position error of various positioning solutions which may fulfil applicable civil aviation requirements for GNSS approaches. In particular, this study focuses on two particular solutions which are: • Combined GPS/GALILEO receivers augmented by RAIM where RAIM is a type of ABAS augmentation. This solution is a candidate to provide a mean to conduct approaches with vertical guidance (APV I, APV II and LPV 200). • GPS L1 C/A receivers augmented by GBAS. This solution should allow to conduct precision approaches down to CAT II/III, thus providing an alternative to classical radio navigation solutions such as ILS. This study deals with the characterization of the statistics of the position error at the output of these GNSS receivers. It is organised as following. First a review of civil aviation requirements is presented. Then, the different GNSS signals structure and the associated signal processing selected are described. We only considered GPS and GALILEO constellations and concentrated on signals suitable for civil aviation receivers. The next section details the GNSS measurement models used to model the measurements made by civil aviation receivers using the previous GNSS signals. The following chapter presents the GPS/GALILEO and RAIM combination model developed as well as our conclusions on the statistics of the resulting position error. The last part depicts the GBAS NSE (Navigation System Error) model proposed in this report as well as the rationales for this model
44
Yildirim, Gokce. "Smoke Simulation On Programmable Graphics Hardware." Master's thesis, METU, 2005. http://etd.lib.metu.edu.tr/upload/12606545/index.pdf.
Abstract:
Fluids such as smoke, water and fire are simulated for both Computer Graphics applications and engineering fields such as Mechanical Engineering. Generally, Fluid Dynamics is used for the achievement of realistic-looking fluid simulations. However, the complexity of these calculations makes it difficult to achieve high performance. With the advances in graphics hardware, it has been possible to provide programmability both at the vertex and the fragment level,
which allows for faster simulations of complex fluids and other events.
In this thesis, one gaseous fluid, smoke is simulated in three dimensions by solving Navier-Stokes Equations (NSEs) using a semi-Lagrangian unconditionally stable method. Simulation is performed both on Central Processing Unit (CPU) and Graphics Processing Unit (GPU). For the programmability at the vertex and the fragment level, C for Graphics (Cg), a platform-independent and architecture neutralshading language, is used. Owing to the advantage of programmability and parallelism of GPU, smoke simulation on graphics hardware runs significantly faster than the corresponding CPU implementation. The test results prove the higher performance of GPU over CPU for running three dimensional fluid simulations.
45
Remédio, Flávio Henrique [UNESP]. "Análise de estabilidade de taludes de aterro de resíduos urbanos utilizando parâmetros geotécnicos de propostas bibliográficas e correlações com Nspt." Universidade Estadual Paulista (UNESP), 2014. http://hdl.handle.net/11449/123741.
Abstract:
Made available in DSpace on 2015-06-17T19:33:49Z (GMT). No. of bitstreams: 0
Previous issue date: 2014-10-24. Added 1 bitstream(s) on 2015-06-18T12:47:59Z : No. of bitstreams: 1
000829981.pdf: 3998595 bytes, checksum: c14c7188a3d0e4c3f9c88dbf48fae831 (MD5)O aumento nas taxas de geração de resíduos, decorrentes do aumento das atividades industriais e do poder de compra da população, frente à escassez de áreas adequadas à disposição de resíduos, próximas aos centros geradores, tem levado as administradoras a investirem no aumento da capacidade de carga de aterros sanitários em operação ou na reutilização de antigas áreas de disposição encerradas, para suprir esta demanda. Esta situação induz a construção de aterros cada vez mais altos, atenuando o problema da demanda de resíduos e, em contrapartida, gerando grandes preocupações quanto à estabilidade destes corpos. Dentro deste contexto, os métodos convencionais de cálculo de estabilidade de taludes são comumente utilizados em estudos de estabilidade em aterros sanitários, por pesquisadores e profissionais especializados. No entanto, estas metodologias de trabalho foram desenvolvidas para estudos em maciços com constituição e comportamento mecânico distintos dos materiais dispostos em aterros sanitários. Desta forma, foram executados estudos sistemáticos com objetivo de determinar parâmetros geotécnicos adequados aos resíduos presentes no Aterro de Caetetuba, localizado no município de Atibaia - SP. Os parâmetros geotécnicos dos resíduos foram determinados com base em propostas levantadas durante a pesquisa bibliográfica e com base em resultados de testes de penetração de sondagens identificadas na pesquisa documental. Diversos métodos de análise de estabilidade de taludes, levantados durante a pesquisa bibliográfica, foram avaliados visando identificar o método mais adequado para aplicação no Aterro Sanitário de Caetetuba. Para realização das análises de estabilidade foram elaboradas seções litoconstrutivas do aterro, com base em plantas topográficas e perfis de sondagens identificados na pesquisa documental, as quais foram implementadas no software SLOPE/W da Geo-Slope International. As...
The increase in waste generation rates, due to the increase of industrial activity and the population's purchasing power, compared to the scarcity of appropriate disposition of the waste areas, close to generating centers, has led managers to invest in increasing the capacity of load landfills in operation or reuse of old disposal areas closed to meet this demand. This leads to the construction of higher and higher landfill, reducing the problem of waste demand and, in turn, generating serious concerns over the stability of these bodies developed for studies in natural massive, with constitution and mechanical behavior of different materials disposed of in landfills. In this way, systematic studies have been performed in order to determine suitable geotechnical parameters waste present in Caetetuba Landfill, located at Atibaia/SP city. The geotechnical parameters of waste were determined based on proposals raised during the literature and based on survey results of penetration tests identified in documentary research. Several methods of slope stability analysis, raised during the literature search were evaluated to identify the most suitable method for applying the landfill Caetetuba of Health. To perform the stability analysis were prepared sections of the site, based on topographic maps and profiles polls identified in documentary research, which were implemented in SLOPE / W Geo-Slope International software. The findings were expressed in terms of security values, and compared the safety factors calculated by the various methods offered by the SLOPE / W software, depending on the variations in geotechnical parameters and analytical methods used. Within this context, the conventional slope stability calculation methods developed in soil mechanics are commonly used in the stability studies in landfills, by researchers and professionals. However, these work methodologies were
46
Vieira, Fernando de Paula. "Critério estatístico para obtenção de valores de NSPT para previsão da capacidade de carga de estacas por métodos semi empíricos." Universidade do Estado do Rio de Janeiro, 2015. http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=8381.
Abstract:
Uma das tarefas mais desafiadoras do engenheiro na área da Geotecnia é a escolha dos valores de parâmetros geotécnicos obtidos de ensaios de campo ou laboratório e que serão utilizados nos modelos analíticos ou numéricos na fase de projeto de fundações. Diante das incertezas inerentes aos ensaios de SPT e da heterogeneidade de abordagens para a utilização dos valores de NSPT, é proposta neste estudo, a aplicação de um critério estatístico para obtenção de valores de NSPT, a partir da construção de intervalos de confiança de 95% de probabilidade em torno da reta ajustada de regressão linear simples entre a variável aleatória NSPT e a profundidade. Os valores obtidos de NSPT pelo critério aplicado foram utilizados na previsão da capacidade de carga de 19 estacas isoladas a partir da utilização de três métodos semi-empíricos: Aoki-Velloso (1975) com coeficientes alterados por Monteiro (1997), Décourt & Quaresma (1978) alterado pelo método de Décourt (1996) e Método de Alonso (1996). As cargas de ruptura dessas 19 estacas ensaiadas através de Provas de Carga Estática foram obtidas pelos métodos de extrapolação de Van Der Veen (1953) e Décourt (1996) e serviram para comparação e consequente validação do critério estatístico. Adicionalmente, com fulcro no item 6.2.1.2.1 da ABNT NBR 6122:2010 Resistência calculada por método semi-empírico, foram avaliados os fatores de segurança em relação às cargas de projeto, inclusive, também se utilizando da premissa de reconhecimento de regiões representativas, levando em conta o número de ensaios de SPT executados, fato que promove uma diminuição da incerteza dos parâmetros, apontando a um menor fator de segurança. A dissertação enfatiza as vantagens de um adequado tratamento estatístico dos parâmetros geotécnicos, a exemplo da recomendação já existente nas normas internacionais como Eurocódigo e outras. O critério construído permite e encoraja análises e decisões racionais no universo das partes interessadas consumidores, projetistas, fiscais de obras, contratantes e comunidade científica promovendo as discussões de forma mais objetiva e harmoniosa sobre o tema.One of the most challenging aspects of geotechnical engineering is the selection of soil parameters from field and / or laboratory tests to be used in analytical or numerical models for foundation design. Due to known uncertainties in SPT tests and wide availability of criteria for NSPT interpretation, a proposed procedure is presented based on 95% confidence limits around a trend line defined by simple linear regression analysis expressing the variation of NSPT with depth. The NSPT values obtained by the proposed approach have been used to estimate the pile ultimate capacity of 19 isolated continuous flight auger piles using different semi-empirical methods, such as Aoki and Velloso (1975) with modified coefficients as proposed by Monteiro (1997), Décourt and Quaresma (1978) modified by Décourt (1996) and Alonso (1996). Static load tests of the same 19 piles have been extrapolated by Van Der Veen (1953) and Décourt (1996) methods, as an aid for comparison and validation of the statistical criterion. Additionally, were made with the fulcrum in item 6.2.1.2.1 of ABNT NBR 6122: 2010 - Resistance calculated by semi-empirical method, evaluations of safety factors in relation to load project, also including the premise of recognizing representative regions and taking into account the number of SPT tests, a fact that provides the decreased uncertainty of the parameters, indicating a lower FS. The dissertation emphasizes the advantages of an adequate statistical treatment of the geotechnical data, similar to what is recommended by the Eurocode. Such approach allows and encourages a more rational decision including all interested parties - consumers, designers, inspectors, contractors and scientific community providing more objective and harmonious discussions on this subject.
47
Remédio, Flávio Henrique. "Análise de estabilidade de taludes de aterro de resíduos urbanos utilizando parâmetros geotécnicos de propostas bibliográficas e correlações com Nspt /." Rio Claro, 2014. http://hdl.handle.net/11449/123741.
Abstract:
Orientador: Leandro Eugênio da Silva CerriBanca: Fábio Augusto Gomes Vieira
Banca: Oswaldo Augusto Filho
Resumo: O aumento nas taxas de geração de resíduos, decorrentes do aumento das atividades industriais e do poder de compra da população, frente à escassez de áreas adequadas à disposição de resíduos, próximas aos centros geradores, tem levado as administradoras a investirem no aumento da capacidade de carga de aterros sanitários em operação ou na reutilização de antigas áreas de disposição encerradas, para suprir esta demanda. Esta situação induz a construção de aterros cada vez mais altos, atenuando o problema da demanda de resíduos e, em contrapartida, gerando grandes preocupações quanto à estabilidade destes corpos. Dentro deste contexto, os métodos convencionais de cálculo de estabilidade de taludes são comumente utilizados em estudos de estabilidade em aterros sanitários, por pesquisadores e profissionais especializados. No entanto, estas metodologias de trabalho foram desenvolvidas para estudos em maciços com constituição e comportamento mecânico distintos dos materiais dispostos em aterros sanitários. Desta forma, foram executados estudos sistemáticos com objetivo de determinar parâmetros geotécnicos adequados aos resíduos presentes no Aterro de Caetetuba, localizado no município de Atibaia - SP. Os parâmetros geotécnicos dos resíduos foram determinados com base em propostas levantadas durante a pesquisa bibliográfica e com base em resultados de testes de penetração de sondagens identificadas na pesquisa documental. Diversos métodos de análise de estabilidade de taludes, levantados durante a pesquisa bibliográfica, foram avaliados visando identificar o método mais adequado para aplicação no Aterro Sanitário de Caetetuba. Para realização das análises de estabilidade foram elaboradas seções litoconstrutivas do aterro, com base em plantas topográficas e perfis de sondagens identificados na pesquisa documental, as quais foram implementadas no software SLOPE/W da Geo-Slope International. As...
Abstract: The increase in waste generation rates, due to the increase of industrial activity and the population's purchasing power, compared to the scarcity of appropriate disposition of the waste areas, close to generating centers, has led managers to invest in increasing the capacity of load landfills in operation or reuse of old disposal areas closed to meet this demand. This leads to the construction of higher and higher landfill, reducing the problem of waste demand and, in turn, generating serious concerns over the stability of these bodies developed for studies in natural massive, with constitution and mechanical behavior of different materials disposed of in landfills. In this way, systematic studies have been performed in order to determine suitable geotechnical parameters waste present in Caetetuba Landfill, located at Atibaia/SP city. The geotechnical parameters of waste were determined based on proposals raised during the literature and based on survey results of penetration tests identified in documentary research. Several methods of slope stability analysis, raised during the literature search were evaluated to identify the most suitable method for applying the landfill Caetetuba of Health. To perform the stability analysis were prepared sections of the site, based on topographic maps and profiles polls identified in documentary research, which were implemented in SLOPE / W Geo-Slope International software. The findings were expressed in terms of security values, and compared the safety factors calculated by the various methods offered by the SLOPE / W software, depending on the variations in geotechnical parameters and analytical methods used. Within this context, the conventional slope stability calculation methods developed in soil mechanics are commonly used in the stability studies in landfills, by researchers and professionals. However, these work methodologies were
Mestre
48
Silva, Daniel Fermino da. "Mapeamento geoestatístico dos parâmetros Nspt e torque máximo de solos em parte da bacia do Ribeirão Cambezinho em Londrina/PR." Universidade Estadual de Londrina. Centro de Tecnologia e Urbanismo. Programa de Pós-Graduação em Engenharia de Edificações e Saneamento, 2008. http://www.bibliotecadigital.uel.br/document/?code=vtls000149824.
Abstract:
O presente estudo teve como objetivo não só o do mapeamento dos parâmetros geotécnicos de resistência à penetração do amostrador-padrão e de Torque Máximo do SPT-T (Standard Penetration Test with Torque Measurement), obtidos a partir de um banco de 238 sondagens realizadas na bacia hidrográfica do ribeirão Cambezinho, que compreende parte da zona urbana da cidade de Londrina/Pr, mas também de correlacionar estas variáveis qualitativamente a fatores tais como a topografia e pedologia. A área em estudo foi de aproximadamente 37 Km². O perfil de solo da área de estudo se constitui de argila siltosa residual, proveniente do intemperismo atuante sobre as rochas basálticas da Formação Serra Geral. A camada de solo superficial possui alta porosidade e comportamentos laterítico e colapsível. Através de ferramentas da estatística descritiva e da estatística espacial, procederam-se a análise, a interpolação e a interpretação dos resultados das sondagens no que se refere ao Torque Máximo e ao NSPT. Estes resultados foram geoprocessados e analisados juntamente com os fatores naturais anteriormente descritos através de mapas topográficos e pedológicos. A principio, para a área urbana da bacia do ribeirão Cambezinho, não se detectou nenhuma correlação entre os índices de resistência do solo medidos no SPT-T e a pedologia ou topografia. Percebeu-se porém que o comportamento espacial da relação dos índices de resistência medidos no SPT-T, NSPT e Torque Máximo, é semelhante ao observado na análise de sondagens isoladas, ou seja, resguardam uma proporção de aproximadamente 1, e que quanto maior o grau de intemperização sofrido pelo solo menor é à resistência que o mesmo apresenta.This study has as its objective to map the resistance geotechnical parameters of NSPT and Maximum Torque, obtained from a data bank of 238 field tests of SPT-T (Standard Penetration Test with Torque Measurement) done in the Cambezinho hydrographic creek basin, that comprehends part of urban zone of the city of Londrina/Pr and to correlate these variables to factors as topography and pedology. The experimental area has approximately 37 km². The geotechnical profile of the experimental area consists in a residual silty clay that originates from the intemperism acting on the basaltic rocks of the Serra Geral Formation. The superficial layer has a high porosity and lateritic and collapsible behavior. Through descriptive and spatial statistics tools were done the analysis, interpolation and the interpretation of the results of the field tests about the Maximum Torque and NSPT measured. Then, the results were geoprocessed and analyzed along with the natural factors explained above through altimetric and pedologic maps. In an early analyses, it was not realized any relation among the SPT-T parameters and the pedology or topography, inside the urban zone of the Cambezinho creek basin. However, it was realized that the spacial behavior of the relation between the resistance parameters measured in the SPT-T ,NSPT and Maximum Torque, is the same as observed in the analyses of isolated tests field, which means that they are approximately equal, and as the bigger is the intemperization level that the soil has suffered the smaller is the resistance it reaches.
49
Pozo, Romero Jaime Augusto del. "Plan de Negocios: Livian: “Yogurt Probiótico Natural con Frutas para el NSE “B” de Lima Metropolitana"." Tesis, Universidad de Chile, 2010. http://www.repositorio.uchile.cl/handle/2250/102278.
50
Wiener, Carolina David. "Níveis séricos de ácido úrico e as atividades a superóxido dismutase e da catalase nos transtornos de humor." Universidade Catolica de Pelotas, 2013. http://tede.ucpel.edu.br:8080/jspui/handle/tede/517.
Abstract:
Submitted by Cristiane Chim (cristiane.chim@ucpel.edu.br) on 2016-10-18T17:20:14Z
No. of bitstreams: 1
carolina - Copia.pdf: 1129007 bytes, checksum: deaef0e96e4837a47c36de1f6dc1e109 (MD5)Made available in DSpace on 2016-10-18T17:20:14Z (GMT). No. of bitstreams: 1 carolina - Copia.pdf: 1129007 bytes, checksum: deaef0e96e4837a47c36de1f6dc1e109 (MD5) Previous issue date: 2013-05-03
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES#
#2075167498588264571#
#600
Objectives: The aim of this study was evaluate uric acid level in a population–based sample of young adults (18 to 24 years old). People with bipolar and depression disorder were compared with healthy psychiatric subjects without a history of mood episodes. Methods: Case-control study nested in a population-based sample. The diagnosis was confirmed with the Structured Clinical Interview for DSM-IV. The uric acid was assessed by commercial kits Results: The sample consisted of 216 subjects, 49 with diagnosis for bipolar disorder, 76 with depression and 91 population control. The uric acid levels were similar (control = 4.08 ± 1.27 mg/dL, depression = 3.78 ± 1.00 mg/dL e bipolar disorder =3.86 ± 1.33 mg/dL, p= 0,251). For maniac/hippomaniac and depressive episodes, were observed a tendency to increase in acid uric levels in maniac/hippomaniac episodes (4.43 ± 1.74 mg/dL) and a decrease in depressive episodes (3.70 ± 0.99 mg/dL) when compared to control subjects (4.08 ± 1.27 mg/dL)(p= 0.106). Conclusion: Uric acid levels is not correlated with diagnosis group, but the uric acid level have a tendency to presented increased in manic and/ or mixed episodes and decreased in depression episode, these result observed that levels of uric acid in mood disorders are altered according to the manifestation of symptoms.
Objetivo: O objetivo deste estudo é avaliar o nível de acido úrico em pacientes com transtornos de humor oriundo de uma amostra de base populacional com jovens adultos (18 a 24 anos), para este fim jovens com transtorno de humor bipolar e depressão foram comparados com jovens sem histórico de transtorno de humor. Métodos: Trata-se de um estudo de caso-controle aninhado a um estudo de base populacional, o diagnostico foi realizado através da Entrevista Clínica Estruturada para o DSM-IV (SCID) e os níveis de acido úrico séricos foram dosados utilizando-se kits comerciais. Resultados: A amostra foi constituída de 216 jovens, 49 com diagnostico de transtorno bipolar, 76 com depressão e 91 controles sem historia psiquiátrica prévia, os níveis de acido úrico entre os três grupos foram similares (controle = 4.08 ± 1.27 mg/dL, depressão = 3.78 ± 1.00 mg/dL e transtorno bipolar =3.86 ± 1.33 mg/dL, p= 0,251). Quando avaliados os níveis de ácido úrico entre os episódios mania/hipomania e depressivo, observa-se uma tendência no aumento do ácido úrico no episódio maníaco/misto (4,43 ± 1,74 mg/dL) e uma diminuição no episódio depressivo (3,70 ± 0,99 mg/dL) quando comparados aos jovens do grupo controle (4,08 ± 1,27 mg/dL)(p= 0,106). Conclusão: Os níveis de ácido úrico não foram significativos entre os grupos diagnósticos, porém os níveis de acido úrico apresentaram uma tendência para o aumento nos episódios maníacos e/ou mistos e uma diminuição no episódio depressivo, com estes resultados podemos observar que os níveis de acido úrico nos transtornos de humor podem estar alterados de acordo com a manifestação dos sintomas