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Academic literature on the topic 'Npl3'

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Published: 9 March 2023
Last updated: 11 March 2023

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Journal articles on the topic "Npl3"

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Henry, Michael, Christina Z. Borland, Mark Bossie, and Pamela A. Silver. "Potential RNA Binding Proteins in Saccharomyces cerevisiae Identified as Suppressors of Temperature-Sensitive Mutations in NPL3." Genetics 142, no. 1 (January 1, 1996): 103–15. http://dx.doi.org/10.1093/genetics/142.1.103.

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The NPL3 gene of the yeast Saccharomyces cerevisiae encodes a protein with similarity to heterogeneous nuclear ribonucleoproteins (hnRNPs). Npl3p has been implicated in many nuclear-related events including RNA export, protein import, and rRNA processing. Several temperature-sensitive alleles of NPL3 have been isolated. We now report the sequence of these alleles. For one allele, npl3-1, four complementation groups of suppressors have been isolated. The cognate genes for the two recessive mutants were cloned. One of these is the previously known RNA15, which, like NPL3, also encodes a protein with similarity to the vertebrate hnRNP A/B protein family. The other suppressor corresponds to a newly defined gene we term HRP1, which also encodes a protein with similarity to the hnRNP A/B proteins of vertebrates. Mutations in HRP1 suppress all npl3 temperature-sensitive alleles but do not bypass an npl3 null allele. We show that HRP1 is essential for cell growth and that the corresponding protein is located in the nucleus. The discovery of two hnRNP homologues that can partially suppress the function of Npl3p, also an RNA binding protein, will be discussed in terms of the possible roles for Npl3p in RNA metabolism.
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Nelson, M. K., T. Kurihara, and P. A. Silver. "Extragenic suppressors of mutations in the cytoplasmic C terminus of SEC63 define five genes in Saccharomyces cerevisiae." Genetics 134, no. 1 (May 1, 1993): 159–73. http://dx.doi.org/10.1093/genetics/134.1.159.

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Abstract Mutations in the SEC63 gene of Saccharomyces cerevisiae affect both nuclear protein localization and translocation of proteins into the endoplasmic reticulum. We now report the isolation of suppressors of sec63-101 (formerly npl1-1), a temperature-sensitive allele of SEC63. Five complementation groups of extragenic mutations, son1-son5 (suppressor of npl1-1), were identified among the recessive suppressors. The son mutations are specific to SEC63, are not bypass suppressors, and are not new alleles of previously identified secretory (SEC61, SEC62, KAR2) or nuclear protein localization genes (NPL3, NPL4, NPL6). son1 mutations show regional specificity of suppression of sec63 alleles. At low temperatures, son1 mutants grow slowly and show partial mislocalization of nuclear antigens. The SON1 gene maps to chromosome IV and encodes a nuclear protein of 531 amino acids that contains two acidic stretches and a putative nuclear localization sequence. We show that son1 mutations suppress sec63-101 by elimination of Son1p function.
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Henry, M. F., and P. A. Silver. "A novel methyltransferase (Hmt1p) modifies poly(A)+-RNA-binding proteins." Molecular and Cellular Biology 16, no. 7 (July 1996): 3668–78. http://dx.doi.org/10.1128/mcb.16.7.3668.

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RNA-binding proteins play many essential roles in the metabolism of nuclear pre-mRNA. As such, they demonstrate a myriad of dynamic behaviors and modifications. In particular, heterogeneous nuclear ribonucleoproteins (hnRNPs) contain the bulk of methylated arginine residues in eukaryotic cells. We have identified the first eukaryotic hnRNP-specific methyltransferase via a genetic screen for proteins that interact with an abundant poly(A)+-RNA-binding protein termed Npl3p. We have previously shown that npl3-1 mutants are temperature sensitive for growth and defective for export of mRNA from the nucleus. New mutants in interacting genes were isolated by their failure to survive in the presence of the npl3-1 allele. Four alleles of the same gene were identified in this manner. Cloning of the cognate gene revealed an encoded protein with similarity to methyltransferases that was termed HMT1 for hnRNP methyltransferase. HMT1 is not required for normal cell viability except when NPL3 is also defective. The Hmt1 protein is located in the nucleus. We demonstrate that Npl3p is methylated by Hmt1p both in vivo and in vitro. These findings now allow further exploration of the function of this previously uncharacterized class of enzymes.
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Lund, Mette K., Tracy L. Kress, and Christine Guthrie. "Autoregulation of Npl3, a Yeast SR Protein, Requires a Novel Downstream Region and Serine Phosphorylation." Molecular and Cellular Biology 28, no. 11 (April 7, 2008): 3873–81. http://dx.doi.org/10.1128/mcb.02153-07.

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ABSTRACT Npl3 is an SR-like protein with documented roles in mRNA export and transcription termination. Maintaining appropriate levels of Npl3 protein is critical for cell survival. Here we show that Npl3 negatively regulates its own expression via modulation of its mRNA levels. By creating gene chimeras, we demonstrate that the region downstream of the coding sequence of Npl3 is necessary and sufficient to confer regulation. The use of different polyadenylation sites in this region results in at least two stable RNAs; read-through of these sites causes the formation of 3′-extended RNAs that are highly unstable and therefore largely unproductive. Increasing the amount of Npl3 protein promotes read-through. Notably, the loss of Npl3 phosphorylation promotes the use of the productive polyadenylation sites, resulting in elevated levels of Npl3 protein. We propose that proper levels of Npl3 protein are achieved by a negative feedback loop in which phosphorylated Npl3 suppresses efficient recognition of the productive processing signals in its own transcript.
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Loo, S., P. Laurenson, M. Foss, A. Dillin, and J. Rine. "Roles of ABF1, NPL3, and YCL54 in silencing in Saccharomyces cerevisiae." Genetics 141, no. 3 (November 1, 1995): 889–902. http://dx.doi.org/10.1093/genetics/141.3.889.

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Abstract A sensitized genetic screen was carried out to identify essential genes involved in silencing in Saccharomyces cerevisiae. This screen identified temperature-sensitive alleles of ORC2 and ORC5, as described elsewhere, and ABF1, NPL3, and YCL54, as described here. Alleles of ABF1 that caused silencing defects provided the genetic proof of Abflp's role in silencing. The roles of Npl3p and Ycl54p are less clear. These proteins did not act exclusively through any one of the three protein binding sites of the HMR-E silencer. Unlike the orc2, orc5, and abf1 mutations that were isolated in the same (or a similar) screen for silencing mutants, neither temperature-sensitive mutation in NPL3 or YCL54 caused overt replication defects.
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Sandhu, Rima, Aniketa Sinha, and Ben Montpetit. "The SR-protein Npl3 is an essential component of the meiotic splicing regulatory network in Saccharomyces cerevisiae." Nucleic Acids Research 49, no. 5 (February 12, 2021): 2552–68. http://dx.doi.org/10.1093/nar/gkab071.

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Abstract The meiotic gene expression program in Saccharomyces cerevisiae involves regulated splicing of meiosis-specific genes via multiple splicing activators (e.g. Mer1, Nam8, Tgs1). Here, we show that the SR protein Npl3 is required for meiotic splicing regulation and is essential for proper execution of the meiotic cell cycle. The loss of Npl3, though not required for viability in mitosis, caused intron retention in meiosis-specific transcripts, inefficient meiotic double strand break processing and an arrest of the meiotic cell cycle. The targets of Npl3 overlapped in some cases with other splicing regulators, while also having unique target transcripts that were not shared. In the absence of Npl3, splicing defects for three transcripts (MER2, HOP2 and SAE3) were rescued by conversion of non-consensus splice sites to the consensus sequence. Methylation of Npl3 was further found to be required for splicing Mer1-dependent transcripts, indicating transcript-specific mechanisms by which Npl3 supports splicing. Together these data identify an essential function for the budding yeast SR protein Npl3 in meiosis as part of the meiotic splicing regulatory network.
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Bossie, M. A., C. DeHoratius, G. Barcelo, and P. Silver. "A mutant nuclear protein with similarity to RNA binding proteins interferes with nuclear import in yeast." Molecular Biology of the Cell 3, no. 8 (August 1992): 875–93. http://dx.doi.org/10.1091/mbc.3.8.875.

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We have isolated mutants of the yeast Saccharomyces cerevisiae that are defective in localization of nuclear proteins. Chimeric proteins containing the nuclear localization sequence from SV40 large T-antigen fused to the N-terminus of the mitochondrial F1 beta-ATPase are localized to the nucleus. Npl (nuclear protein localization) mutants were isolated by their ability to grow on glycerol as a consequence of no longer exclusively targeting SV40-F1 beta-ATPase to the nucleus. All mutants with defects in localization of nucleolar proteins and histones are temperature sensitive for growth at 36 degrees C. Seven alleles of NPL3 and single alleles of several additional genes were isolated. NPL3 mutants were studied in detail. NPL3 encodes a nuclear protein with an RNA recognition motif and similarities to a family of proteins involved in RNA metabolism. Our genetic analysis indicates that NPL3 is essential for normal cell growth; cells lacking NPL3 are temperature sensitive for growth but do not exhibit a defect in localization of nuclear proteins. Taken together, these results indicate that the mutant forms of Npl3 protein isolated by this procedure are interfering with nuclear protein uptake in a general manner.
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Rollenhagen, Christiane, Christine A. Hodge, and Charles N. Cole. "Following Temperature Stress, Export of Heat Shock mRNA Occurs Efficiently in Cells with Mutations in Genes Normally Important for mRNA Export." Eukaryotic Cell 6, no. 3 (January 26, 2007): 505–13. http://dx.doi.org/10.1128/ec.00317-06.

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ABSTRACT Heat shock leads to accumulation of polyadenylated RNA in nuclei of Saccharomyces cerevisiae cells, transcriptional induction of heat shock genes, and efficient export of polyadenylated heat shock mRNAs. These studies were conducted to examine the requirements for export of mRNA following heat shock. We used in situ hybridization to detect SSA4 mRNA (encoding Hsp70) and flow cytometry to measure the amount of Ssa4p-green fluorescent protein (GFP) produced following heat shock. Npl3p and Yra1p are mRNA-binding proteins recruited to nascent mRNAs and are essential for proper mRNA biogenesis and export. Heat shock mRNA was exported efficiently in temperature-sensitive npl3, yra1, and npl3 yra1 mutant strains. Nevertheless, Yra1p was recruited to heat shock mRNA, as were Nab2p and Npl3p. Interestingly, Yra1p was not recruited to heat shock mRNA in yra1-1 cells, suggesting that Npl3p is required for recruitment of Yra1p. The THO complex, which functions in transcription elongation and in recruitment of Yra1p, was not required for heat shock mRNA export, although normal mRNA export is impaired in growing cells lacking THO complex proteins. Taken together, these studies indicate that export following heat shock depends upon fewer factors than does mRNA export in growing cells. Furthermore, even though some mRNA-binding proteins are dispensable for efficient export of heat shock mRNA, those that are present in nuclei of heat shocked cells were recruited to heat shock mRNA.
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Flach, J., M. Bossie, J. Vogel, A. Corbett, T. Jinks, D. A. Willins, and P. A. Silver. "A yeast RNA-binding protein shuttles between the nucleus and the cytoplasm." Molecular and Cellular Biology 14, no. 12 (December 1994): 8399–407. http://dx.doi.org/10.1128/mcb.14.12.8399-8407.1994.

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RNA-binding proteins have been suggested to move in association with RNA as it leaves the nucleus. The NPL3 gene of the yeast Saccharomyces cerevisiae encodes in nuclear protein with consensus RNA-binding motifs and similarity to heterogeneous nuclear ribonucleoproteins and members of the S/R protein family. We show that although Npl3 is located in the nucleus, it can shuttle between nuclei in yeast heterokaryons. In contrast, other nucleus-targeted proteins do not leave the nucleus under similar conditions. Mutants missing the RNA-binding motifs or the N terminus are still capable of shuttling in and out of the nucleus. Npl3 mutants missing the C terminus fail to localize to the nucleus. Overproduction of Npl3 in wild-type cells shows cell growth. This toxicity depends on the presence of series of unique repeats in the N terminus and localization to the nucleus. We suggest that the properties of Npl3 are consistent with it being involved in export of RNAs from the nucleus.
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Flach, J., M. Bossie, J. Vogel, A. Corbett, T. Jinks, D. A. Willins, and P. A. Silver. "A yeast RNA-binding protein shuttles between the nucleus and the cytoplasm." Molecular and Cellular Biology 14, no. 12 (December 1994): 8399–407. http://dx.doi.org/10.1128/mcb.14.12.8399.

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RNA-binding proteins have been suggested to move in association with RNA as it leaves the nucleus. The NPL3 gene of the yeast Saccharomyces cerevisiae encodes in nuclear protein with consensus RNA-binding motifs and similarity to heterogeneous nuclear ribonucleoproteins and members of the S/R protein family. We show that although Npl3 is located in the nucleus, it can shuttle between nuclei in yeast heterokaryons. In contrast, other nucleus-targeted proteins do not leave the nucleus under similar conditions. Mutants missing the RNA-binding motifs or the N terminus are still capable of shuttling in and out of the nucleus. Npl3 mutants missing the C terminus fail to localize to the nucleus. Overproduction of Npl3 in wild-type cells shows cell growth. This toxicity depends on the presence of series of unique repeats in the N terminus and localization to the nucleus. We suggest that the properties of Npl3 are consistent with it being involved in export of RNAs from the nucleus.
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Dissertations / Theses on the topic "Npl3"

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Baierlein, Claudia [Verfasser], and Heike [Akademischer Betreuer] Krebber. "Analysen des SR-Proteins Npl3 in der Translation und Charakterisierung von SR-Domänen-vermittelten Protein-Interaktionen von Npl3 / Claudia Baierlein. Betreuer: Heike Krebber." Marburg : Philipps-Universität Marburg, 2014. http://d-nb.info/1051934346/34.

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Pérez, Martínez Lara [Verfasser]. "Npl3 stabilizes R-loops at telomeres to regulate replicative senescence / Lara Pérez Martínez." Mainz : Universitätsbibliothek Mainz, 2019. http://d-nb.info/1201695651/34.

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COLOMBO, CHIARA VITTORIA. "New insights into the regulation of DNA end processing and DNA damage checkpoint." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2019. http://hdl.handle.net/10281/241167.

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L’integrità genomica è minacciata da danni al DNA che, se non adeguatamente riparati, si convertono in mutazioni, il cui accumulo causa instabilità genomica, una tipica caratteristica tumorale. Le cellule eucariotiche reagiscono ai danni attivando la risposta ai danni al DNA. Le rotture a doppia elica del DNA (DSB) sono tra i danni più pericolosi. In Saccharomyces cerevisiae i DSB sono principalmente riparati tramite ricombinazione omologa (HR), che sfrutta sequenze omologhe come stampo per riparare il danno. La HR necessita il processamento nucleolitico (resection) delle estremità del DSB così da generare code di DNA a singolo filamento (ssDNA). La resection inizia con un taglio endonucleolitico da parte del complesso MRX insieme a Sae2, mentre l’estensione della resection è eseguita dalle nucleasi Exo1 e Dna2. Il checkpoint da danno al DNA è una cascata di trasduzione del segnale che blocca il ciclo cellulare così che le cellule abbiano tempo sufficiente per riparare il danno. In S. cerevisiae il checkpoint è attivato dalle chinasi Tel1 e Mec1, ortologhe di ATM e ATR umane. Una volta attivate, Mec1 e Tel1 fosforilano diversi substrati, tra cui l’adattatore Rad9 e la chinasi effettrice Rad53, che amplificano il segnale. Sia la resection che il checkpoint devono essere finemente regolati per garantire una riparazione efficiente dei DSB, evitando di generare troppo ssDNA, e per coordinare la riparazione con la progressione del ciclo. In questa tesi di dottorato, abbiamo dimostrato un nuovo livello di regolazione della resection, basato sul controllo della quantità di Exo1 da parte della proteina che lega l’RNA (RBP) Npl3. Inoltre, abbiamo studiato il ruolo di Sae2 nella riparazione dei danni e nell’attivazione del checkpoint. Npl3 svolge un ruolo chiave nel metabolismo degli RNA ed è molto conservata nell’uomo. Poiché studi recenti mostrano forti connessioni tra metabolismo degli RNA e mantenimento dell’integrità genomica, abbiamo verificato se Npl3 fosse coinvolta nella risposta ai DSB. Abbiamo dimostrato che l’assenza di Npl3 provoca difetti nel processamento delle estremità del DSB. In particolare, Npl3 promuove la resection estesa, agendo nello stesso pathway di Exo1. Inoltre, sia l’assenza di Npl3 che l’inattivazione dei suoi domini di legame all’RNA causano una riduzione del livello di Exo1. Quindi, Npl3 promuove la resection estesa regolando EXO1 a livello dell’RNA. Infatti, in assenza di Npl3, abbiamo dimostrato la presenza di molecole di RNA di EXO1 non correttamente terminate. Questi dati, oltre al fatto che l’overespressione di EXO1 sopprime parzialmente il difetto di resection di cellule npl3Δ, suggeriscono che Npl3 partecipi alla regolazione della resection promuovendo la corretta biogenesi dell’mRNA di EXO1. Riguardo al secondo progetto, Sae2 promuove l’attività endonucleasica di MRX durante la resection e regola negativamente il checkpoint Tel1-dipendente. Infatti, Sae2 limita l’accumulo di MRX alla lesione, riducendo sia il reclutamento che l’attività di segnalazione di Tel1. Non è ancora chiaro come le funzioni di Sae2 nel promuovere la resistenza ai danni e nell’inibire il checkpoint siano collegate. Tramite screening genetico, abbiamo identificato il mutante sae2-ms che, come accade in assenza di Sae2, iperattiva il checkpoint Tel1-dipendente, aumentando il reclutamento ai DSB sia di MRX che di Tel1. A differenza della delezione di Sae2, Sae2-ms non causa difetti di resection né di tethering, e non provoca sensibilità agli agenti genotossici. Inoltre, Sae2-ms provoca iperattivazione di Tel1, ma non di Rad53. Infatti, l’assenza di Sae2, ma non la presenza di Sae2-ms, aumenta l’interazione tra Rad53 e Rad9. Questi dati dimostrano che Sae2 regola il checkpoint sia controllando la rimozione di MRX dai DSB che limitando l’interazione Rad53-Rad9, e che l’inibizione di Rad53 è la principale responsabile della resistenza ai danni promossa da Sae2.
Genomic integrity is threatened by DNA damage that, if not properly repaired, can be converted into mutations, whose accumulation leads to genomic instability, one of the hallmarks of cancer. Eukaryotic cells deal with DNA damage by activating DNA damage response. DNA double strand breaks (DSBs) are among the most dangerous DNA lesions. In Saccharomyces cerevisiae, DSBs are mainly repaired by Homologous Recombination (HR), which exploits a homologous sequence as a template to repair the damage. HR requires the DSB ends to be nucleolytically degraded in order to generate single-strand DNA (ssDNA) tails, in a process known as DSB end resection. Resection initiates with an endonucleolytic cleavage by the MRX complex together with Sae2, while resection extension is carried out by the nucleases Exo1 and Dna2. DNA damage checkpoint is a signal transduction cascade that halts the cell cycle in order to give cells sufficient time to repair the damage. In S. cerevisiae, DNA damage checkpoint is activated by the kinases Tel1 and Mec1, orthologues of human ATM and ATR. Once activated, Mec1 and Tel1 phosphorylate different substrates including the adaptor Rad9 and the effector kinase Rad53, which allow signal amplification. Both DNA end resection and DNA damage checkpoint must be finely regulated to ensure efficient DSB repair, avoiding excessive ssDNA generation, and to properly coordinate repair with cell cycle progression. In this PhD thesis, we provide evidences of a new level of resection regulation, based on the modulation of Exo1 amount by the RNA-binding protein (RBP) Npl3. We have also studied the role of Sae2 in DNA damage repair and checkpoint activation. Npl3 is a S. cerevisiae RBP, which plays a central role in RNA metabolism and is highly conserved from yeast to humans. Since emerging evidences support strong connections between RNA metabolism and genome integrity, we investigated if Npl3 was involved in DSB response. We demonstrated that the absence of Npl3 impairs the generation of long ssDNA tails at DSB ends. In particular, Npl3 promotes resection extension by acting in the same pathway of Exo1. Moreover, both the lack of Npl3 and the inactivation of its RNA-binding domains cause the reduction of Exo1 protein level. So, Npl3 promotes resection extension by regulating EXO1 at the RNA level. Indeed, we proved that the decrease of Exo1 level is due to the presence of not properly terminated EXO1 RNA species. These findings, together with the observation that EXO1 overexpression partially suppresses the resection defect of npl3Δ cells, suggest that Npl3 participates in DSB end resection regulation by promoting the proper biogenesis of EXO1 mRNA. Concerning the second PhD project, Sae2 promotes MRX endonucleolytic activity during resection and negatively regulates Tel1-dependent checkpoint response. Indeed, Sae2 limits MRX accumulation at the damage site, thus reducing Tel1 recruitment and its signalling activity. How Sae2 functions in supporting DNA damage resistance and in inhibiting the DNA damage checkpoint are connected is still unclear. From a genetic screen, we identified the sae2-ms mutant that, similarly to Sae2 absence, upregulates Tel1 signalling activity by increasing both MRX and Tel1 recruitment to the DSBs. However, unlike SAE2 deletion, Sae2-ms does not cause any resection or tethering defect, nor any sensitivity to genotoxic agents. Moreover, Sae2-ms induces Tel1 but not Rad53 hyperactivation. Indeed Sae2 absence, but not Sae2-ms presence, increases Rad53-Rad9 interaction. These data indicate that Sae2 regulates checkpoint activation both by controlling MRX removal from the DSBs and by limiting Rad53-Rad9 interaction and that Rad53 downregulation is the main responsible for Sae2-promoted DNA damage resistance. Altogether, our results allow to better understand the molecular mechanisms involved in the control of DNA damage response processes.
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Coordes, Britta. "Ctk1 function is crucial for efficient translation initiation and interacts with the mRNP processing factor Npl3." Diss., lmu, 2011. http://nbn-resolving.de/urn:nbn:de:bvb:19-132032.

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Coordes, Britta [Verfasser], and Roland [Akademischer Betreuer] Beckmann. "Ctk1 function is crucial for efficient translation initiation and interacts with the mRNP processing factor Npl3 / Britta Coordes. Betreuer: Roland Beckmann." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2011. http://d-nb.info/101508382X/34.

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Schneider, Ulla-Maria [Verfasser], Heike [Akademischer Betreuer] Krebber, Heike [Gutachter] Krebber, and Oliver [Gutachter] Valerius. "Characterization of Npl3-mediated RNA quality control in Saccharomyces cerevisiae / Ulla-Maria Schneider ; Gutachter: Heike Krebber, Oliver Valerius ; Betreuer: Heike Krebber." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2018. http://d-nb.info/1173975020/34.

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Cauda, Luca <1992&gt. "The Italian NPLs market: UniCredit case study." Master's Degree Thesis, Università Ca' Foscari Venezia, 2017. http://hdl.handle.net/10579/11904.

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Panoramica del quadro attuale della situazione dei crediti deteriorati in Italia, le soluzioni offerte dai governi e dalla banche centrali e la presentazione del progetto FINO di UniCredit relativo alla vendita di circa 17 miliardi di Euro di crediti deteriorati.
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Koch, Tina Strafuss Michael. "NPL-Verkauf durch deutschen Banken /." Frankfurt am Main : Bankakad, 2006. http://deposit.ddb.de/cgi-bin/dokserv?id=2765271&prov=M&dok_var=1&dok_ext=htm.

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Bell, Stephanie A. "Validation of the NPL gravimetric hygrometer." Thesis, City University London, 1995. http://openaccess.city.ac.uk/7703/.

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The gravimetric hygrometer of the UK National Physical Laboratory (NPL) provides a first-principles realisation of mixing ratio - the most fundamental measure of the humidity of a gas. The operation of the NPL gravimetric hygrometer has been validated to demonstrate its satisfactory performance as a primary standard for humidity within the UK national measurement system. The measurement performance of the gravimetric hygrometer has been characterised for mixing ratios within the range 0.01 g kg to 155 g kg 4 (equivalent at atmospheric pressure to a dew-point range of -60 °C to +60 °C). The significant aspects of the measurement have been assessed in detail; these being the balances and weighing processes, the efficiency of collecting water and dry gas, and the effects of stray water in the instrument. Sources of systematic error have been identified and their effects quantified. Wherever possible, such errors have been eliminated or reduced. Elsewhere, numerical corrections have been evaluated and applied to the results of measurements. The overall uncertainty of measurement for the gravimetric hygrometer has been estimated by evaluating the uncertainties contributed by each aspect of the measurement, and combining these statistically to find the overall effect. The estimated uncertainty at a level of confidence of approximately 95% (a coverage factor of k=2) was found to range between 0.015 percent of value at the highest humidity considered, near 155 g kg 1, and 1.27 percent of value at the lower limit of 0.01 g kg1. The gravimetric hygrometer has been intercompared with the humidity generator which is the NFL standard for dew point, using nitrogen as the carrier gas in these measurements. For the conversion between values of dew point and mixing ratio, the uncertainties in the reference functions have been reviewed for the vapour pressure curve of water, and for the water vapour enhancement factor which accounts for the non-ideal behaviour of humid gases. A new calculation of the enhancement factor for nitrogen is presented. The uncertainties due to sampling were also evaluated. On average, the uncertainties due to the reference functions and those due to sampling were found to comparable with the uncertainty in the gravimetric measurements. Taking all these into account, the intercomparison measurements agreed to within the combined uncertainties of the two instruments.
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Fukuda, Karina 1985. "Caracterização de óleos essenciais com atividade antifúngica por cromatografia gasosa bidimensiona abrangente GCxGC." [s.n.], 2012. http://repositorio.unicamp.br/jspui/handle/REPOSIP/250211.

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Orientadores: Fabio Augusto, Adílson Sartoratto
Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Química
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Resumo: O perfil cromatográfico de óleos essenciais de Mentha foi correlacionado com sua atividade biológica contra Candida dubliniensis utilizando-se ferramentas quimiométricas. A cromatografia gasosa bidimensional "abrangente" com detecção por ionização em chama, GCxGC-FID, foi combinada com a análise multivariada de dados e, a partir da correlação obtida com o emprego da ferramenta NPLS-DA (N-way partial least squares - discriminant analysis), foi possível prever o comportamento de novas amostras de óleo de Mentha frente à atividade biológica classificando-as como ativas ou inativas, sem a necessidade de se efetuar o ensaio de concentração inibitória mínima, MIC. Foi possível, ainda, estimar os principais constituintes responsáveis pela atividade contra Candida dubliniensis: linalol, piperitona, carvona, pulegona e óxido de piperitenona. Desta forma, a GCxGC-FID, quando combinada com técnicas quimiométricas, pode vir a ser uma ferramenta poderosa na predição de propriedades biológicas como uma alternativa ou complemento para outras técnicas mais laboriosas. Paralelamente, a GCxGC-qMS foi empregada para realizar a identificação tentativa de duas espécies de folhas de Mentha. Cada espécie foi submetida aos tratamentos de secagem e congelamento. Para a pré-concentração dos analitos foi empregada a etapa de preparo de amostras por microextração em fase sólida através do headspace (HS-SPME) empregando-se fibra de polidimetilssiloxano / divinilbenzeno (PDMS/DVB) seguida de separação por cromatografia gasosa bidimensional "abrangente" com detecção por espectrometria de massas (GCxGC-qMS)
Abstract: The chromatographic profile of essencial oils Mentha was correlated with their biological activities against Candida dubliniensis using chemometric tools. Comprehensive two-dimensional gas chromatography with flame ionization detection (GCxGC-FID) was combined with multivariate data analysis and correlation obtained from the use of tool NPLS-DA (N-way partial least squares - discriminant analysis), making it possible to predict the behavior of new samples of Mentha oil against biological activity by classifying them as active or inactive, without the need to perform the minimal inhibitory concentration test. It was also possible to estimate the major components responsible for the activity against Candida dubliniensis: linalool, piperitona, carvone, pulegone and piperitenone oxide. Thus, GC x GC-FID, when combined with chemometric techniques, may prove to be a powerfull tool for predicting biological properties as an alternative or complement to other techniques. In parallel, GC x GC-qMS was used to perform the identification of two species of leaves of Mentha. Each species was subjected to drying and freezing treatments. Solid phase microextraction through headspace (HS-SPME) was employed for sample preparation with a fiber employing polydimethylsiloxane/divinylbenzene (PDMS/DVB), followed by separation by comprehensive two-dimensional gas chromatography with mass spectrometer detection (GC x GC-qMS)
Mestrado
Quimica Analitica
Mestra em Química
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Books on the topic "Npl3"

1

National Physical Laboratory (Great Britain). NPL points of contact. Teddington: National Physical Laboratory, 2001.

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National Physical Laboratory (Great Britain). NPL points of contact 1985. Teddington: National Physical Laboratory, 1998.

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National Physical Laboratory (Great Britain). NPL points of contact 1985. Teddington: National Physical Laboratory, 1985.

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National Physical Laboratory (Great Britain). NPL points of contact 1999-2000. Teddington: National Physical Laboratory, 1999.

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Dong, He. The role of KAMCO in resolving nonperforming loans in the Republic of Korea. [Washington D.C.]: International Monetary Fund, Asia and Pacific Dept., 2004.

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Branch, National Physical Laboratory (Great Britain) Acoustics. Index of NPL acoustics publications 1971-1980. Teddington: National Physical Laboratory, 1985.

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Program, Montana Natural Resource Damage Litigation. Modifications to assessment plan: Clark Fork Basin NPL sites, Montana. Helena?, MT: Dept. of Justice?, 1995.

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Inc, RCG/Hagler Bailly. Assessment plan: Part II, Clark Fork River Basin NPL sites, Montana. Helena, Mont.]: State of Montana, Natural Resource Damage Program, 1992.

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Montana. Natural Resource Damage Program. Assessment plan: Part III, Clark Fork River Basin NPL sites, Montana. Helena, Mont.]: State of Montana, Natural Resource Damage Program, 1994.

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Phitthayāwiwit, Chanin. Wikrit sētthakit, thurakit NPL sathāban kānngœ̄n čha yū rō̜t dai yāngrai. Krung Thēp: ʻAksō̜n Sōphon, 2002.

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Book chapters on the topic "Npl3"

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Horstkorte, Rüdiger, Bettina Büttner, Kaya Bork, Navdeep Sahota, Sarah Sabir, Laura O’Regan, Joelle Blot, et al. "Npn3." In Encyclopedia of Signaling Molecules, 1261. New York, NY: Springer New York, 2012. http://dx.doi.org/10.1007/978-1-4419-0461-4_100936.

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Müller, Birgit Charlotte. "The Pricing of European Non-Performing Real Estate Loan Portfolios." In Three Essays on Empirical Asset Pricing in International Equity Markets, 94–126. Wiesbaden: Springer Fachmedien Wiesbaden, 2021. http://dx.doi.org/10.1007/978-3-658-35479-4_4.

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ZusammenfassungNon-performing loans (NPL), commonly referred to as loans in arrears for at least 90 days, have continuously been characterized as the top priority of the European Central Bank (ECB) and continue to attract central attention (ECB, 2018a,b). With the outbreak of the European debt crisis, the quality of banks’ assets had deteriorated in a manner that, despite robust economic recovery and a variety of regulatory efforts, NPL still today pose a threat to bank and thrift institutions. Against this backdrop, the European regulator requires banks to develop effective strategies for reducing NPL, to set up clear governance and to operate powerful work-out structures (ECB, 2017).
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Villars, P., K. Cenzual, J. Daams, R. Gladyshevskii, O. Shcherban, V. Dubenskyy, V. Kuprysyuk, and I. Savysyuk. "[ClP(NPCl3)3]Cl." In Structure Types. Part 9: Space Groups (148) R-3 - (141) I41/amd, 371. Berlin, Heidelberg: Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-642-02702-4_258.

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de Juan, Aristóbulo. "Non-performing Loans: NPLs." In From Good to Bad Bankers, 115–22. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-11551-7_13.

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Singh, Dalvinder. "EU Non-Performing Loans and Loan Loss Provisioning." In European Cross-Border Banking and Banking Supervision, 93–114. Oxford University Press, 2020. http://dx.doi.org/10.1093/oso/9780198844754.003.0005.

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This chapter focuses on the issue of non-performing loans (NPLs), which is critical in the home and host dilemma because of the significant level of cross-border banking that exists at the European level. Indeed, the NPL problem is one of the negative consequences of the push and pull factors of cross-border banking. The move towards consistent practices in the management of NPLs is exemplified by regulatory measures concerning loan loss provisions. In particular, the interlinkages between loan loss provisioning and capital requirements and how they interact with banks and their balance sheet combine a multitude of regulatory decisions directly and indirectly at the accounting and prudential supervisory level. The dynamics of private and public forms of regulation require a systematic discussion of how best to combine and interpret the reforms at European level.
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Wolton, Laura P., Deserai A. Crow, and Tanya Heikkila. "Stepping Forward: Towards a More Systematic NPF with Automation." In Narratives and the Policy Process : Applications of the Narrative Policy Framework. Montana State University, 2021. http://dx.doi.org/10.15788/npf3.

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Advancements in automated text analysis have substantially increased our capacity to study large volumes of documents systematically in policy process research. The Narrative Policy Framework (NPF)—which promotes empirical analysis of narratives—has the potential to usher policy narrative research along the same path. Using the NPF and existing semi-automated analysis tools, we investigate the relationship between narrative components—namely, characters and proposed solutions—and the more “skeletal” frames that tie policy narrative elements to one another. To illustrate how these tools can advance policy narrative research, we auto-code 5,708 state and local news articles focusing on hydraulic fracturing of oil and gas. The findings suggest that the use and role of characters and policy solutions are portrayed in significantly different ways depending on the frame used. By using an autocoding approach, these findings increase our methodological and theoretical understanding of the relationship between narrative elements and frames in policy narratives. In discussing these findings, we also consider their implications for how issue frames matter theoretically in the NPF.
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"Npn3." In Encyclopedia of Signaling Molecules, 3562. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-67199-4_102597.

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"pits [npl] and quarries [npl]." In Encyclopedic Dictionary of Landscape and Urban Planning, 698. Berlin, Heidelberg: Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-540-76435-9_9662.

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"interactions [npl] and interrelationships [npl]." In Encyclopedic Dictionary of Landscape and Urban Planning, 485. Berlin, Heidelberg: Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-540-76435-9_6662.

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"interactions [npl] and relationships [npl]." In Encyclopedic Dictionary of Landscape and Urban Planning, 485. Berlin, Heidelberg: Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-540-76435-9_6663.

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Conference papers on the topic "Npl3"

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Petra, Maria, and George H. Miley. "Thermal blooming in NPLs." In High-Power Laser Ablation, edited by Claude R. Phipps. SPIE, 1998. http://dx.doi.org/10.1117/12.321511.

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Petra, M., G. H. Miley, E. Batyrbekov, D. L. Jassby, and D. McArthur. "Prospects for fusion neutron NPLs." In Laser interaction and related plasma phenomena: 12th international conference. AIP, 1996. http://dx.doi.org/10.1063/1.50553.

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Li, Ming, Yong Cui, Matti Siekkinen, and Antti Yla-Jaaski. "NPLA: Network Prefix Level Authentication." In 2010 Ieee Globecom Workshops. IEEE, 2010. http://dx.doi.org/10.1109/glocomw.2010.5700338.

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Robinson, I. A. "The NPL Mark II Watt Balance: Final measurements at NPL." In 2010 Conference on Precision Electromagnetic Measurements (CPEM 2010). IEEE, 2010. http://dx.doi.org/10.1109/cpem.2010.5544421.

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Raftopoulou, Kerasina. "Policy proposals for management of NPLs portfolios." In 22nd Annual European Real Estate Society Conference. European Real Estate Society, 2015. http://dx.doi.org/10.15396/eres2015-ind_108.

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Wilson, Jacob S., Wipula P. R. Liyanage, Michelle L. Gegel, Manashi Nath, and Edward C. Kinzel. "Scalable Nanomanufacturing of Metasurfaces Using Nanosphere Photolithography." In ASME 2014 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2014. http://dx.doi.org/10.1115/imece2014-38969.

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We report on using Nanosphere Photolithography (NPL) for submicron patterning of Frequency Selective Surfaces (FSS). NPL is a combination of two techniques; colloidal nanolithography — where nanospheres form a self-assembled hexagonal close-packed (HCP) array when dispensed on a surface, and photonic jets — which are created when light is incident onto a microsphere in contact with a surface. NPL creates a mask-free HCP hole array in the photoresist. This pattern can be used with evaporation and lift-off to create an array of antenna elements, constituting the FSS. Alternatively, electrodeposition techniques can be used to deposit the metal elements. The later is particularly appealing as it lends itself to reel-to-reel fabrication techniques. Finally, we demonstrate that geometries other than simple hole arrays can be patterned in the photoresist by exposing the microsphere array with off normal incidence light.
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Silva, André, and Suzanne Wells. "NPL Training: delivering measurement skills." In 17th International Congress of Metrology, edited by Bernard Larquier. Les Ulis, France: EDP Sciences, 2015. http://dx.doi.org/10.1051/metrology/20150019002.

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Usadi, Eric, and Laura Crane. "Laser-based spectrometry at NPL." In Optical Science and Technology, SPIE's 48th Annual Meeting, edited by Leonard M. Hanssen. SPIE, 2003. http://dx.doi.org/10.1117/12.509179.

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Olaniya, Mahavir Prasad, Suchi Yadav, Preeti Kandpal, Mohit Dixit, and Ashish Agarwal. "Timescale Algorithm at CSIR-NPL." In 2019 URSI Asia-Pacific Radio Science Conference (AP-RASC). IEEE, 2019. http://dx.doi.org/10.23919/ursiap-rasc.2019.8738334.

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Hill, Ian R., Richard Hobson, William Bowden, Marco Schioppo, Alissa Silva, Patrick Gill, Helen Margolis, Paul H. Huillery, and Matthew P. A. Jones. "Sr Lattice Clocks at NPL." In 2018 IEEE International Frequency Control Symposium (IFCS). IEEE, 2018. http://dx.doi.org/10.1109/fcs.2018.8597491.

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Reports on the topic "Npl3"

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de Rooij, L. L., and J. J. L. Sluijsmans. Grenzeloze 8RHK : werkdocument Preverkenning NPLG. Wageningen: Wageningen Environmental Research, 2021. http://dx.doi.org/10.18174/550225.

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Lines, K., and H. Krishnamurthy. Model-based systems engineering at NPL: an initial investigation. National Physical Laboratory, February 2023. http://dx.doi.org/10.47120/npl.ms42.

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Chunnilall, C., T. Lindstrom, I. Rungger, R. Godun, O. Kazakova, H. Margolis, S. Bhandari, I. May, and R. Lewis. International standards development for quantum technologies (NPL representation and provision of technical expertise). National Physical Laboratory, November 2021. http://dx.doi.org/10.47120/npl.tqe19.

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Zarr, Robert R., Jiyu Wu, and Hung-Kung; Liu. NIST-NPL bilateral comparison of guarded-hot-plate laboratories from 20 °C to 160 °C. Gaithersburg, MD: National Institute of Standards and Technology, January 2020. http://dx.doi.org/10.6028/nist.tn.2059.

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Yani, Nor. PENGARUH CAPITAL ADEQUACY RATIO (CAR) DAN NON PERFORMING LOAN (NPL) TERHADAP PROFITABILITAS (STUDI KASUS PADA BANK BUMN). Jurnal Madani: Ilmu Pengetahuan, Teknologi, dan Humaniora, September 2018. http://dx.doi.org/10.33753/madani.v1i2.18.

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Cooke, E., M. Hayes, M. Romanchikova, A. Dexter, R. Steven, S. Thomas, M. Shaw, et al. Acquisition & management of high content screening, light-sheet microscopy and mass spectrometry imaging data at AstraZeneca, GlaxoSmithKline and NPL. National Physical Laboratory, September 2020. http://dx.doi.org/10.47120/npl.mn25.

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Cooke, E., M. Hayes, M. Romanchikova, A. Dexter, R. Steven, S. Thomas, M. Shaw, et al. Acquisition & management of high content screening, light-sheet microscopy and mass spectrometry imaging data at AstraZeneca, GlaxoSmithKline and NPL. National Physical Laboratory, September 2020. http://dx.doi.org/10.47120/npl.ms25.

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Thomas, D. J., and M. Bunce. Features of the neutron spectra produced using tritium targets currently available for neutron production with the T(d,n)4He reaction at NPL - June 2022. National Physical Laboratory, October 2022. http://dx.doi.org/10.47120/npl.ir62.

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Brochu, F., E. Cooke, M. Romanchikova, J. Bunch, A. Dexter, R. Steven, S. Thomas, et al. Federation of imaging data for life sciences current status of metadata collection for high content screening, mass spectrometry imaging and light sheet microscopy of AstraZeneca, GlaxoSmithKline and NPL. National Physical Laboratory, September 2020. http://dx.doi.org/10.47120/npl.mn24.

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Brochu, F., E. Cooke, m. Romanchikova, J. Bunch, A. Dexter, R. Steven, S. Thomas, et al. Federation of imaging data for life sciences current status of metadata collection for high content screening, mass spectrometry imaging and light sheet microscopy of AstraZeneca, GlaxoSmithKline and NPL. National Physical Laboratory, September 2020. http://dx.doi.org/10.47120/npl.ms24.

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