Relevant bibliographies by topics / Novel Methodologies

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Novel Methodologies'

Author: Grafiati
Published: 18 May 2024

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Journal articles on the topic "Novel Methodologies"

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Ng, Vivian G., and Alexandra J. Lansky. "Novel QCA methodologies and angiographic scores." International Journal of Cardiovascular Imaging 27, no. 2 (February 2011): 157–65. http://dx.doi.org/10.1007/s10554-010-9787-9.

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Hoefer, Imo E., Sabine Steffens, Mika Ala-Korpela, Magnus Bäck, Lina Badimon, Marie-Luce Bochaton-Piallat, Chantal M. Boulanger, et al. "Novel methodologies for biomarker discovery in atherosclerosis." European Heart Journal 36, no. 39 (June 5, 2015): 2635–42. http://dx.doi.org/10.1093/eurheartj/ehv236.

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Adams, Dave J., James H. Clark, Paul A. Heath, Liv B. Hansen, Victoria C. Sanders, and Stewart J. Tavener. "Novel synthetic methodologies for fluorination and perfluoroalkylation." Journal of Fluorine Chemistry 101, no. 2 (February 2000): 187–91. http://dx.doi.org/10.1016/s0022-1139(99)00157-8.

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Frippiat, Christophe, Sabrina Zorbo, Daniel Leonard, Anne Marcotte, Mariella Chaput, Charlotte Aelbrecht, and Fabrice Noel. "Evaluation of novel forensic DNA storage methodologies." Forensic Science International: Genetics 5, no. 5 (November 2011): 386–92. http://dx.doi.org/10.1016/j.fsigen.2010.08.007.

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Conceição, Luis E. C., Cláudia Aragão, Nadège Richard, Sofia Engrola, Paulo Gavaia, Sara Mira, and Jorge Dias. "Novel methodologies in marine fish larval nutrition." Fish Physiology and Biochemistry 36, no. 1 (December 25, 2009): 1–16. http://dx.doi.org/10.1007/s10695-009-9373-z.

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Cappelli, Darren, Brian Glennon, and Philip Donnellan. "Development of novel solvent swap methodologies using CFD." Chemical Engineering Science 253 (May 2022): 117515. http://dx.doi.org/10.1016/j.ces.2022.117515.

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Tekkam, Srinivas, M. A. Alam, Subash C. Jonnalagadda, and Venkatram R. Mereddy. "Novel methodologies for the synthesis of functionalized pyroglutamates." Chemical Communications 47, no. 11 (2011): 3219. http://dx.doi.org/10.1039/c0cc05609j.

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Gabriel, Rodney A., and Brian M. Ilfeld. "Novel Methodologies in Regional Anesthesia for Knee Arthroplasty." Anesthesiology Clinics 36, no. 3 (September 2018): 387–401. http://dx.doi.org/10.1016/j.anclin.2018.05.002.

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Cheng, Ming Soon, and Chee-Seng Toh. "Novel biosensing methodologies for ultrasensitive detection of viruses." Analyst 138, no. 21 (2013): 6219. http://dx.doi.org/10.1039/c3an01394d.

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Asprone, D., F. Auricchio, and A. Reali. "Novel finite particle formulations based on projection methodologies." International Journal for Numerical Methods in Fluids 65, no. 11-12 (March 30, 2010): 1376–88. http://dx.doi.org/10.1002/fld.2327.

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Dissertations / Theses on the topic "Novel Methodologies"

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Massolo, E. "NOVEL SYNTHETIC ORGANOCATALYTIC METHODOLOGIES." Doctoral thesis, Università degli Studi di Milano, 2015. http://hdl.handle.net/2434/330262.

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The objective of this PhD study was to apply organocatalytic synthetic methods for the regio- and stereoselective synthesis of highly functionalized compounds. We exploited different organocatalytic activation modes to peculiar substrates we identified as suitable building blocks for versatile products in enantiomerically enriched form. In particular the developed projects relied on stereoselective amino- and hydrogen bonding organocatalysis, employing beta-nitroacrylates, beta-trifluoromethylated nitroalkenes and 2,2,2-trifluoroethyl 2-[(1,3-dithian)-2-yl]-ethanthioate in combination with various reaction partners, thus finding entries to valuable intermediates suitable for further subsequent transformations. The first Chapter of this thesis aim to give a general overview on those fields of organocatalysis related to the research topics studied in this PhD program, the second Chapter offers a literature background of the employed substrates. Following five Chapters (3-7) and Appendix report the discussion on the obtained results. According to our opinion, this PhD study offers solid examples of robustness, versatility and effectiveness of stereoselective organocatalytic strategies, which have been applied to interesting starting materials and in innovative reaction media, thus giving a reliable contribution to expand the boundaries of this field.
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Pujol-Santiago, Alba. "Development of novel catalytic asymmetric diborylation methodologies." Thesis, Durham University, 2017. http://etheses.dur.ac.uk/12161/.

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This thesis describes the study of the β-borylation reaction on different types of electron deficient substrates as well as the application of the methodologies herein developed into the synthesis of a key intermediate for cholesterol-lowering drug Atorvastatin. Within the frame of the use of organoboron compounds in organic synthesis, the literature review presented in the first section after a brief introduction on organoboranes is focused on the different strategies for their synthesis via boron addition, specially the β-borylation reaction. Different aspects of the reaction are covered; enantioselective version, the different methodologies reported for the activation of the diborane reagents or organic electron deficient substrates. Within the study of the β-borylation reaction on α,β-unsaturated aldehydes via the in situ generated amine-derived aldimine intermediates, and the further application of these synthetically attractive compounds, the relevant challenge of handling β-boryl aldehydes was met. It was confirmed that this type of compound was indeed unstable especially under chromatographic purification conditions, leading to de-borylation. In addition, mechanistic studies were carried out in order to achieve a better understanding of the whole process, but it was not possible to clarify it and avoid the undesired side-process. Hence, the establishment of an efficient derivatisation methodology was required. The solution consisted of a mild, efficient derivatisation process involving an in situ copper(II) sulfate-based imine hydrolysis followed by Wittig trapping of the resulting aldehyde. Further exploitation of homoallylic boronate carboxylate esters as substrates for a second borylation reaction, led to obtaining versatile 1,3-diborylated esters. A novel methodology was developed which allowed the control of the asymmetry induced in the new stereogenic centre created for a range of substrates, due to the presence of the two boryl units which could subsequently be transformed into other functionalities leading to building blocks for the synthesis of multi-functional, chiral compounds. Therefore, the two boryl units were then examined for transformation into functionalities which would allow unambiguous stereochemical assignment of the two borylation reactions. Specifically, an oxidation/acetal formation sequence was examined showing that 6-membered ring acetonide acetals were ideal compounds for this purpose. Beside aiding the stereochemical analysis, it was confirmed that this dual asymmetric borylation methodology was useful for the synthesis of 3,5-dihydroxy acids (or esters analogous) side-chain present in many natural products or drugs, such as statin-type drugs. Complementarily, and with the aim of expanding the type of substrates for the β-borylation reaction, structurally varied compounds were examined. Firstly, substrates presenting an additional unsaturation were evaluated under the imine formation/β-borylation reaction sequence conditions paying special attention to the 1,4- vs 1,6-addition selectivity, were examined as a possible alternative for the synthesis of diborylated compounds in a direct manner. This was followed by the study of different unsaturation, and in particular, an alkyne instead of an alkene, i.e. α,β-acetylenic carbonyl compounds, which were envisioned as ideal platforms for the synthesis of vinyl boronates. As well as a brief study on the β-borylation reaction on β-enamino ester substrates which could a priori give rise to valuable α-amino boronate compounds, is reported.
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Lattimore, Brian Steven. "Novel methodologies for the analysis of microarray data." Thesis, University of Reading, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.483566.

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Haji, Dheere Abdul Karim. "Novel [¹¹C]CO₂ radiolabelling methodologies for PET neuroimaging." Thesis, King's College London (University of London), 2015. http://kclpure.kcl.ac.uk/portal/en/theses/novel-11cco2-radiolabelling-methodologies-for-pet-neuroimaging(a28f9e70-d697-4d69-afec-a8c3c34f1e93).html.

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PET is a non-invasive molecular imaging technique that is increasingly being used for medical imaging and drug development. Carbon-11 (11C; half-life 20.4 min) is one of the most commonly used radionuclides for PET molecular imaging. 11C is usually produced in the form of [11C]CO2 and converted into more reactive secondary precursors such as [11C]methyl iodide and [11C]carbon monoxide for radiolabelling. Although such secondary precursors are undoubtedly useful, given the short half-life of 11C, it would be advantageous to use [11C]CO2 directly from the cyclotron without additional time-consuming processing. Therefore, the development of radiochemical methods to efficiently radiolabel compounds directly with [11C]CO2 for applications in PET neuroimaging is an important goal and is the focus of this thesis. This work includes the development of novel radiolabelling methodology utilising [11C]CO2 for the radiolabelling of molecules based on urea and carbamate scaffolds. These functional groups are found in a plethora of biologically active molecules and pharmaceuticals. As proof of concept, the utility of the developed radiochemistry methods were applied to the synthesis of novel GABA and glutamate radiotracers. GABA and glutamate are major excitatory and inhibitory neurotransmitters in the brain. Although implicated in many diseases, the in vivo function of these neurotransmitter system is poorly understood. Their dysfunction are implicated in pathologies such as addiction, Alzheimer’s disease, Parkinson’s disease and autism. Monitoring the expression of the receptors in vivo and in vitro would enable better understanding of these diseases, their progression and treatment. The research described in this thesis unveils new methods to radiolabel novel molecules for these targets with 11C thereby enabling more opportunities to study them in vitro using autoradiography and in vivo using PET molecular imaging.
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Saha, Bittu. "Development of Novel methodologies for the construction of c-hetero bond." Thesis, University of North Bengal, 2018. http://ir.nbu.ac.in/handle/123456789/2823.

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Brun, Cubero Omar. "Novel methodologies for the conjugation and cyclisation of polyamides." Doctoral thesis, Universitat de Barcelona, 2016. http://hdl.handle.net/10803/399912.

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An alternative allowing diene-derivatised polyamides to be used in Diels-Alder conjugation reactions has been explored and developed. In this methodology, conjugation takes place between a fully protected, resin-linked diene-derivatised polyamide and a soluble maleimide- containing compound. The acid-labile diene is thus not exposed to acids, and the acidic deprotection treatment that follows does not affect the cycloadduct. In contrast with previously described alternatives, this methodology has no limitations in terms of sequence and does not require special protecting groups. (E)-4,6-Heptadienoyl-polyamide-resins are used due to the good yields observed in the Diels- Alder reaction and the stability of the generated compounds. Polyamides are assembled using the standard, commercially available building blocks on water-swelling solid matrixes, and no special building blocks need to be synthesised. Both water and organic solvent/water mixtures can be used for the on-resin cycloaddition, and simultaneous maleimide deprotection and on- resin Diels-Alder cycloaddition is feasible, allowing conjugates with different linking sites to be prepared. The on-resin Diels-Alder reaction is also compatible with the wide-spread maleimide- thiol reaction, and combination of both transformations is feasible, making it possible to synthesise double conjugates. However, diene-derivatised oligonucleotides do not withstand the reaction conditions required for the solid-phase Diels-Alder conjugation, meaning that peptide- oligonucleotide conjugates cannot be prepared using this methodology. In a different project, 2,2-disubstituted cyclopent-4-ene-1,3-diones (CPDs), which were chosen as non-hydrolysable maleimide analogs, have been found to possess an unexpected reactivity. While maleimides react in an irreversible manner with all types of thiols, the Michael-type reaction between CPDs and cysteines placed at internal or C-terminal positions, which do not possess a free amine, is reversible. In contrast, cysteines with a free amine (at the N-terminus of peptides) react with CPDs to end up furnishing a stable product with a mass 20 Da lower (M- 20 Da) than the Michael-type adduct (weighing M Da). Formation of the M-20 Da adduct plausibly takes place through the following steps: First, conjugate addition of the N-terminal cysteine thiol to the CPD double bond yields a Michael-type adduct. This product immediately undergoes intramolecular imine formation, by reaction between one of the CPD keto groups and the N-terminal amine, giving an intermediate with two fused rings and a mass 18 Da lower (M- 18 Da) than the initially formed Michael-type adduct. Subsequent oxidation of this M-18 Da adduct provides the final, stable M-20 Da adduct, which absorbs around 330 nm and whose structure has been confirmed by NMR. This newly found reactivity can be applied for different purposes. Firstly, CPD-derivatised peptides can be used to synthesise conjugates by reaction with cysteine-derivatised PNAs. Secondly, the different reactivity of CPDs towards 1,2-aminothiols and other thiols has been exploited to selectively tag a peptide containing an N-terminal cysteine in the presence of peptides with cysteines in other positions, and to double-derivatise a peptide that contains an N- terminal and an internal cysteine. Use of CPDs with this last type of peptides also allows for their simultaneous cyclisation and derivatisation. Formation of the CPD-M-20 Da adduct is followed by Michael-type addition of the internal thiol to this adduct, and finally by oxidation to yield a conjugated system absorbing around 370 nm. Cyclisation has been assessed by NMR experiments. The cyclisation reaction is accelerated by the presence of oxidants, namely O2 or TEMPO, and the addition of LiCl also has a beneficial effect, in particular with difficult to cyclise sequences. In this respect, it has been found that aromatic residues proximal to the N-terminal cysteine hinder the cyclisation. The N-terminal cysteine of CPD-cyclised peptides undergoes epimerisation at the α carbon when exposed to bases, as confirmed by synthesis of the cyclic analogs from peptides with a D- cysteine at the N-terminus. Curiously, the latter are less prone to epimerise than the L-cysteine counterparts, for which reason use of the non-proteinogenic residue is recommended.
En esta tesis se ha llevado a cabo el desarrollo de nuevas metodologías para la conjugación y ciclación de péptidos y otras poliamidas. En un primer proyecto, se buscó y encontró una alternativa que permitiera la conjugación de poliamidas derivatizadas con un 1,3-dieno generadas por síntesis en fase sólida, evitando la descomposición del dieno durante la desprotección final. Para ello se puso a punto una metodología que permitió conjugar, a través de una reacción de Diels-Alder, dichas poliamidas mientras se aún se encontraban protegidas y unidas a resina. Como dienófilos se usaron derivados de maleimida, debido a su fácil obtención, buena reactividad y su disponibilidad comercial. La reacción de Diels-Alder sobre resina se efectuó tanto en agua como en mezclas agua/disolvente orgánico, y es compatible con el uso de maleimidas protegidas y con la reacción de tipo Michael entre un tiol y una maleimida. En un proyecto distinto, se usaron ciclopent-4-en-1,3-dionas 2,2-disustituidas (CPDs) como análogos no hidrolizables de maleimida. Pronto se descubrió que su reactividad es muy distinta a la de las maleimidas, y que, mientras que su reacción con cisteínas internas o C-terminales es reversible, cuando reaccionan con cisteínas N-terminales se genera un producto estable. Éste tiene una masa 20 unidades menor (M-20 Da) que el producto de tipo Michael inicialmente esperado (M Da) un máximo de absorción alrededor de 330 nm. Esta distinta reactividad se ha usado tanto para la formación de conjugados como para la diferenciación de péptidos que poseen cisteína en la posición N-terminal frente a péptidos que la contienen en otras posiciones. Además, las CPDs también se pueden usar para conseguir la ciclación y derivatización simultánea de péptidos que contienen dos cisteínas, una de las cuales se encuentra en la posición N-terminal. En este caso se obtienen derivados cíclicos de masa M-22 Da con un máximo de absorción alrededor de 370 nm. Se recomienda el uso de D-cisteína en la posición N-terminal debido a su mayor estabilidad frente a la epimerización.
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Anand, Sumit. "Novel applications of data mining methodologies to incident databases." Texas A&M University, 2003. http://hdl.handle.net/1969.1/3998.

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Incident databases provide an excellent opportunity to study the repeated situations of incidents in the process industry. The databases give an insight into the situation which led to an incident, and if studied properly can help monitor the process, equipment and chemical involved more closely, and reduce the number of incidents in the future. This study examined a subset of incidents from National Response Center’s Incident database, focusing mainly on fixed facility incidents in Harris County, Texas from 1990 to 2002. Data mining has been used in the financial and marketing arena for many decades to analyze and find patterns in large amounts of data. Realizing the limited capabilities of traditional methods of statistics, more robust techniques of data mining were applied to the subset of data and interesting patterns of chemical involved, equipment failed, component involved, etc. were found. Further, patterns obtained by data mining on the subset of data were used in modifying probabilities of failure of equipment and developing a decision support system.
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Eymur, Serkan. "Development Of Novel Catalytic Methodologies For Carboncarbon Bond Construction." Phd thesis, METU, 2012. http://etd.lib.metu.edu.tr/upload/12615303/index.pdf.

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Addition reactions of nucleophilic trifluoromethyltrimethylsilane (CF3TMS) to acyl phosphonates were investigated. Various acyl phosphonates reacted readily with CF3TMS in the presence of K2CO3 to give 1-alkyl-2,2,2-trifluoro-1-trimethylsilyloxyethylphosphonate in 70-90% yields. When benzoyl phosphonates were used as starting material, after addition of CF3, the formed alcoholate undergoes phosphonatephosphate rearrangement to form the acyl anion, followed by elimination of F- to give 1-aryldifluoroethenyl phosphates in 87-97% yields. The proline&ndash
thiourea host&ndash
guest complex catalyzed intermolecular aldol reaction of aromatic aldehydes with cyclohexanone is developed. The anti-configured products were obtained in high yields and exclusively excellent nantioselectivities. The reaction is proposed to proceed according to a modified Houk&ndash
List model, in which the carboxylate moiety of the proline forms an assembly with the thiourea. These results clearly demonstrate the enormous effect of the thiourea on the reactivity and selectivity, even in an unconventional non-polar reaction medium, without the need to use low temperatures. A proline&ndash
thiourea host&ndash
guest complex is described as a good catalyst for the enantioselective nitro-Michael addition of aldehydes to nitroalkenes. The reaction is efficient with 5% of the thiourea, to give moderate to good enantioselectivity (up to 76% ee). High syn-selectivity was obtained with both branched and unbranched aliphatic aldehydes. This is the first example of self-assembly of organocatalysts with an achiral additive in a Michael addition wherein aldehydes are utilized as donors. An aldol reaction catalyzed by a proline&ndash
thiourea host&ndash
guest complex in a nonpolar solvent shows excellent nonlinear effects. This proline&ndash
thiourea system has the ability to form a hydrogen-bonding network. The enantiomeric excess of proline in a solution can be significantly enhanced by its incorporation with a urea molecule into its solid racemate. This suggests a general and facile route to homochirality, which may be involved in the origin of chirality on earth.
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Oswald, Magalie Florence. "Novel synthetic methodologies for the synthesis of heterocyclic rings." Thesis, University of Sussex, 2010. http://sro.sussex.ac.uk/id/eprint/2348/.

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Part 1. Synthesis of Stereodefined Heterocyclic Rings. We wish to report the development of novel methodology for the synthesis of stereodefined heterocyclic rings, which could be used for the synthesis of natural products containing for example tetrahydrofuran motifs, such as members of the pamamycin family. Due to their ambivalent properties, organoaluminium reagents can easily react with acetals by transfering an alkyl group after prior coordination with the substrates. This work has led to the development of a novel cascade reaction. It involves the reaction of acetals with trialkylaluminium reagents, which is followed by a cyclisation reaction, generating consequently tetrahydrofuran or tetrahydropyran rings. In addition, investigation towards the synthesis of pyrrolidines was also carried out. Part 2. Investigation and Development of a Novel Cascade Reaction. The Bergman cycloaromatisation reaction is based on the formation of a biradical intermediate species and has been, over the years, a constant source of inspiration for scientists. Continued efforts over the last 40 years permitted, among other things, a better understanding of the mode of action of the enediyne antibiotics, a class of natural compounds with exceptional biological activities. The Parsons group recently developed a novel cyclisation reaction, which also generates a biradical species, and which could, after being trapped with a suitable alkene, lead to the formation of tricyclic molecules containing heterocyclic cores. As a result, we wish to further investigate this novel reaction and develop a tandem reaction, involving this reaction combined with a Diels-Alder reaction in order to generate pentacyclic molecules, in one synthetic operation, and from an acyclic precursor.
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Bourne, Samuel. "Development of novel gas-flow methodologies for pharmaceutical synthesis." Thesis, University of Cambridge, 2015. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.708895.

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Books on the topic "Novel Methodologies"

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Hassan, Isra Sayed. Monomeric Streptavidin Artificial Metalloenzymes for the Development of Novel Reaction Methodologies. [New York, N.Y.?]: [publisher not identified], 2021.

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Thullen, Scott Macmillan. Novel Methodologies for the Photochemical and Photocatalytic Generation of Nitrogen-Containing Pharmacophores. [New York, N.Y.?]: [publisher not identified], 2018.

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Perry, S. F. The development of novel methodologies in the investigation of modifications to freeze-drying protocols effecting improvements in cell viability. London: University of East London, 1995.

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Estévez Cuervo, Hernando Arturo, ed. Teaching to discern. Bogotá. Colombia: Universidad de La Salle. Ediciones Unisalle, 2019. http://dx.doi.org/10.19052/9789585486782.

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The issue of academic environments involves both research and practice. It gathers theoretical and practical pieces of knowledge for a permanent analysis and evaluation of pedagogy, content, and accomplishments in the educational field. Moreover, educational practices no longer occur within the boundaries of a specific field; in a globalized world, those practices must overcome their traditional boundaries in order to expand to different disciplines and to different ways of understanding pedagogy. In our time, knowledge travels; ideas and experiences are shared in educational platforms worldwide while educators and students create novel ways to collectively participate in research projects that contribute to a greater understanding of the universe. The anthology Teaching to Discern: Forming Connections, Decolonizing Perspectives aims to provide a novel context for academic dialogue on globalized pedagogical practices. Specifically, it focuses on what it means to teach abroad, which means discussing methodologies, pedagogies and contents used by educators who have had the opportunity of teaching in a foreign country. This book is a dialogue that engages academic experiences in a theoretically expansive and encompassing methodological and content-driven framework around the topic of teaching abroad.
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Watson, M. D. Novel methodologies in pyridine chemistry. 2002.

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Optical Fiber Interferometric Sensors: New Production Methodologies and Novel Applications. MDPI, 2022. http://dx.doi.org/10.3390/books978-3-0365-2250-0.

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Bayat, Mohammad. Novel Methodologies for the Synthesis of Indole Derived Heterocyclic Scaffolds. Nova Science Publishers, Incorporated, 2019.

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Wright, David Thomas. Novel analysis and modelling methodologies applied to pultrusion and other processes. 1995.

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Engler, David Andrew. Novel statistical modeling and selection methodologies for high dimensional genomic data. 2007.

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Lipman, Peter Jason. Novel Methodologies in Statistical Genetics for the Discovery of Causal Variants. 2011.

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Book chapters on the topic "Novel Methodologies"

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Bhushan Petlu, Paul Bharath, N. L. Kumar Anantapalli, Devaki Pendlimarri, and M. Muralidhara Rao. "Novel Methodologies to Avert Hacker." In Communications in Computer and Information Science, 112–20. Berlin, Heidelberg: Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-24043-0_12.

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Li, Xiaochun, Fangqi Li, Ying Guo, and Jinchao Huang. "Gaussian Iteration: A Novel Way to Collaborative Filtering." In Intelligent Computing Methodologies, 260–70. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-42297-8_25.

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Qu, Zhaoyang, Wei Ding, Nan Qu, Jia Yan, and Ling Wang. "A Novel Clustering Algorithm for Large-Scale Graph Processing." In Intelligent Computing Methodologies, 349–58. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-42297-8_33.

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Li, ChenXing, YaJun Du, Jia Liu, Hao Zheng, and SiDa Wang. "A Novel Approach of Identifying User Intents in Microblog." In Intelligent Computing Methodologies, 391–400. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-42297-8_37.

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Liu, Si, Yunxia Liu, Cong Feng, and Hongguo Zhao. "A Novel DCT-Based Video Steganography Algorithm for HEVC." In Intelligent Computing Methodologies, 604–14. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-031-13832-4_49.

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Tian, Weidong, Chuang Guo, Yang Xie, Hongjuan Zhou, and Zhongqiu Zhao. "A Novel Concise Representation of Frequent Subtrees Based on Density." In Intelligent Computing Methodologies, 432–42. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-26766-7_40.

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Xi, Chen, Wu Zongze, Zhang Xie, Xiang Youjun, and Xie Shengli. "One Novel Rate Control Scheme for Region of Interest Coding." In Intelligent Computing Methodologies, 139–48. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-42297-8_14.

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Li, XiaoHong, TingNian He, HongYan Ran, and XiaoYong Lu. "A Novel Graph Partitioning Criterion Based Short Text Clustering Method." In Intelligent Computing Methodologies, 338–48. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-42297-8_32.

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Zheng, Hao, YaJun Du, SiDa Wang, ChenXing Li, and JianBo Yang. "A Novel Entity Relation Extraction Approach Based on Micro-Blog." In Intelligent Computing Methodologies, 401–10. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-42297-8_38.

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Li, Juan, Yahui Dong, Hui Xu, Hui Sun, and Miao Qi. "A Novel Gaze Detection Method Based on Local Feature Fusion." In Intelligent Computing Methodologies, 380–93. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-031-13832-4_32.

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Conference papers on the topic "Novel Methodologies"

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Ibe, Eishi, Ken-ichi Shimbo, Tadanobu Toba, Yoshio Taniguchi, and Hitoshi Taniguchi. "Novel SER standards: Backgrounds and methodologies." In Technology (ICICDT). IEEE, 2010. http://dx.doi.org/10.1109/icicdt.2010.5510259.

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Cao, Yu (Kevin). "Session details: Novel design and verification methodologies." In DAC '09: The 46th Annual Design Automation Conference 2009. New York, NY, USA: ACM, 2009. http://dx.doi.org/10.1145/3257655.

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Kainz, Ondrej, Miroslav Michalko, Frantisek Jakab, Rastislav Petija, Jana Uramova, and Marek Moravcik. "On Teaching of Computer Networks using Novel Methodologies." In 2020 18th International Conference on Emerging eLearning Technologies and Applications (ICETA). IEEE, 2020. http://dx.doi.org/10.1109/iceta51985.2020.9379177.

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Faenzi, M., D. Gonzalez-Ovejero, and S. Maci. "Design Methodologies For Dual-band Modulated Metasurface Antennas." In 2021 Fifteenth International Congress on Artificial Materials for Novel Wave Phenomena (Metamaterials). IEEE, 2021. http://dx.doi.org/10.1109/metamaterials52332.2021.9577156.

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Pial, Mohammad Mohtasim Hamid, Ghaleb Saleh Ghaleb Al-Duhni, Mudit Khasgiwala, and Pulugurtha Markondeya Raj. "Novel Metamaterial Design for Electromagnetic Interference Mitigation between Transmission Lines." In 2023 IEEE Design Methodologies Conference (DMC). IEEE, 2023. http://dx.doi.org/10.1109/dmc58182.2023.10412596.

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"DEFINING AND USING A METAMODEL FOR DOCUMENT-CENTRIC DEVELOPMENT METHODOLOGIES." In 2th International Conference on Evaluation of Novel Approaches to Software Engineering. SciTePress - Science and and Technology Publications, 2007. http://dx.doi.org/10.5220/0002586400330040.

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Sridhar, A., M. Cauwe, H. Fledderus, R. H. L. Kusters, and J. van den Brand. "Novel interconnect methodologies for ultra-thin chips on foils." In 2012 IEEE 62nd Electronic Components and Technology Conference (ECTC). IEEE, 2012. http://dx.doi.org/10.1109/ectc.2012.6248834.

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Espinola, Richard L., Jae Cha, and Kevin Leonard. "Novel methodologies for the measurement of atmospheric turbulence effects." In SPIE Defense, Security, and Sensing, edited by Gerald C. Holst and Keith A. Krapels. SPIE, 2010. http://dx.doi.org/10.1117/12.852294.

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Hadjiloucas, Sillas. "Overview of novel measurement and identification methodologies for advancing." In 2021 IEEE International Conference on Sensors and Nanotechnology (SENNANO). IEEE, 2021. http://dx.doi.org/10.1109/sennano51750.2021.9642520.

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Gharia, Kinjal N., Palak V. Desai, and Monali R. Gandhi. "Review Paper on Novel Recommendation." In 2018 Second International Conference on Computing Methodologies and Communication (ICCMC). IEEE, 2018. http://dx.doi.org/10.1109/iccmc.2018.8487749.

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Reports on the topic "Novel Methodologies"

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Caulfield, H. John, and Marius Schamchula. Database Creation, Management, and Integration Novel Methodologies, Techniques and Technologies. Office of Scientific and Technical Information (OSTI), June 2005. http://dx.doi.org/10.2172/901436.

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Bahar, Ofir, Leonardo De La Fuente, Bryce W. Falk, and Noa Sela. Novel strategies and methodologies to control and study Candidatus Liberibacter diseases. United States Department of Agriculture, January 2015. http://dx.doi.org/10.32747/2015.7600029.bard.

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Pietrobelli, Carlo, and Elisa Giuliani. Social Network Analysis Methodologies for the Evaluation of Cluster Development Programs. Inter-American Development Bank, November 2011. http://dx.doi.org/10.18235/0008963.

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Cluster development programs (CDPs) have been adopted widely in many countries worldwide. Many such programs aim to promote economic development by forming and strengthening inter-organizational networks. Despite their widespread diffusion, we know very little about CDP outputs or the impact CDPs have on host regions and their populations. Evaluation studies are beginning to appear, but the overall concern is that a distinct evaluation concept and method with a focus on CDPs is not yet available. The objective of this paper is to address this limitation, by proposing a novel methodological approach in the evaluation of CDPs based on the application of concepts and methods of social network analysis (SNA).
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Cheng, Meng-Dawn. Development and Application of Novel Sampling Methodologies for Study of Volatile Particulate Matter in Military Aircraft Emissions. Fort Belvoir, VA: Defense Technical Information Center, September 2012. http://dx.doi.org/10.21236/ada581970.

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Perdigão, Rui A. P. Earth System Dynamic Intelligence - ESDI. Meteoceanics, April 2021. http://dx.doi.org/10.46337/esdi.210414.

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Earth System Dynamic Intelligence (ESDI) entails developing and making innovative use of emerging concepts and pathways in mathematical geophysics, Earth System Dynamics, and information technologies to sense, monitor, harness, analyze, model and fundamentally unveil dynamic understanding across the natural, social and technical geosciences, including the associated manifold multiscale multidomain processes, interactions and complexity, along with the associated predictability and uncertainty dynamics. The ESDI Flagship initiative ignites the development, discussion and cross-fertilization of novel theoretical insights, methodological developments and geophysical applications across interdisciplinary mathematical, geophysical and information technological approaches towards a cross-cutting, mathematically sound, physically consistent, socially conscious and operationally effective Earth System Dynamic Intelligence. Going beyond the well established stochastic-dynamic, information-theoretic, artificial intelligence, mechanistic and hybrid techniques, ESDI paves the way to exploratory and disruptive developments along emerging information physical intelligence pathways, and bridges fundamental and operational complex problem solving across frontier natural, social and technical geosciences. Overall, the ESDI Flagship breeds a nascent field and community where methodological ingenuity and natural process understanding come together to shed light onto fundamental theoretical aspects to build innovative methodologies, products and services to tackle real-world challenges facing our planet.
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Perdigão, Rui A. P. Beyond Quantum Security with Emerging Pathways in Information Physics and Complexity. Synergistic Manifolds, June 2022. http://dx.doi.org/10.46337/220602.

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Information security and associated vulnerabilities have long been a pressing challenge, from the fundamental scientific backstage to the frontline across the most diverse sectors of society. At the tip of the iceberg of this problem, the citizens immediately feel that the reservation of privacy and the degradation of the quality and security of the information and communication on which they depend for the day-to-day activities, already of crucial relevance, are at stake. Naturally though, the challenges do not end there. There is a whole infrastructure for storing information, processing and communication, whose security and reliability depend on key sectors gearing modern society – such as emergency communication systems (medical, civil and environmental protection, among others), transportation and geographic information, the financial communications systems at the backbone of day-to-day transactions, the information and telecommunications systems in general. And crucially the entire defence ecosystem that in essence is a stalwart in preventing our civilisation to self-annihilate in full fulfilment of the second principle of thermodynamics. The relevance of the problem further encompasses the preservation of crucial values such as the right to information, security and integrity of democratic processes, internal administration, justice, defence and sovereignty, ranging from the well-being of the citizen to the security of the nation and beyond. In the present communication, we take a look at how to scientifically and technically empower society to address these challenges, with the hope and pragmatism enabled by our emerging pathways in information physics and complexity. Edging beyond classical and quantum frontiers and their vulnerabilities to unveil new principles, methodologies and technologies at the core of the next generation system dynamic intelligence and security. To illustrate the concepts and tools, rather than going down the road of engineered systems that we can ultimately control, we take aim at the bewildering complexity of nature, deciphering new secrets in the mathematical codex underlying its complex coevolutionary phenomena that so heavily impact our lives, and ultimately bringing out novel insights, methods and technologies that propel information physics and security beyond quantum frontiers.
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Eparkhina, Dina. EuroSea Legacy Report. EuroSea, 2023. http://dx.doi.org/10.3289/eurosea_d8.12.

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EuroSea is a holistic large-scale project encompassing the full value chain of marine knowledge, from observations to modelling and forecasting and to user-focused services. This report summarizes the legacy of EuroSea as planned and measured through a dedicated impact monitoring protocol, a holistic assessment of the project's successes in advancing and integrating European ocean observing and forecasting systems. Since its start, EuroSea has been analysing how well the project progresses towards the identified areas of impact. Impact assessment is not performance evaluation. These terms overlap but are distinct: performance relates to the efficient use of resources; impact relates to the transformative effect on the users. The EuroSea legacy report is presented through an aggregation and analysis of the EuroSea work towards achieving its impacts. Overall, over 100 impacts have been identified and presented on the website and in a stand-alone impact report. The legacy report sheds light on 32 most powerful impacts (four impacts in each of the eight EuroSea impact areas). EuroSea Impact Areas: 1. Strengthen the European Ocean Observing System (EOOS), support the Global Ocean Observing System (GOOS) and the GOOS Regional Alliances; 2. Increase ocean data sharing and integration; 3. Deliver improved climate change predictions; 4. Build capacity, internally in EuroSea and externally with EuroSea users, in a range of key areas; 5. Develop innovations, including exploitation of novel ideas or concepts; shorten the time span between research and innovation and foster economic value in the blue economy; 6. Facilitate methodologies, best practices, and knowledge transfer in ocean observing and forecasting; 7. Contribute to policy making in research, innovation, and technology; 8. Raise awareness of the need for a fit for purpose, sustained, observing and forecasting system in Europe. Ocean observing and forecasting is a complex activity brining about a variety of technologies, human expertise, in water and remote sensing measurements, high-volume computing and artificial intelligence, and a high degree of governance and coordination. Determining an impact on a user type or an area, therefore, requires a holistic assessment and a clear strategic overview. The EuroSea impact monitoring protocol has been the first known such attempt in a European ocean observing and forecasting project. The project’s progress has been followed according to the identified impact areas, through consortium workshops, stakeholder webinars, tracking, and reporting. At the end of EuroSea, we are able to demonstrate how well we have responded to the European policy drivers set out in the funding call and the grant agreement of our project, signed between the European Commission and 53 organizations, members of the EuroSea consortium. The project's impact is diverse, spanning areas from strengthening ocean observing governance to contributing to policymaking or boosting ocean research, innovation, and technology. Each impact area underscores EuroSea's commitment to a sustainable and informed approach to ocean observing and forecasting for enhanced marine knowledge and science-based sustainable blue economy and policies. (EuroSea Deliverable, D8.12)
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Saville, Alan, and Caroline Wickham-Jones, eds. Palaeolithic and Mesolithic Scotland : Scottish Archaeological Research Framework Panel Report. Society for Antiquaries of Scotland, June 2012. http://dx.doi.org/10.9750/scarf.06.2012.163.

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Why research Palaeolithic and Mesolithic Scotland? Palaeolithic and Mesolithic archaeology sheds light on the first colonisation and subsequent early inhabitation of Scotland. It is a growing and exciting field where increasing Scottish evidence has been given wider significance in the context of European prehistory. It extends over a long period, which saw great changes, including substantial environmental transformations, and the impact of, and societal response to, climate change. The period as a whole provides the foundation for the human occupation of Scotland and is crucial for understanding prehistoric society, both for Scotland and across North-West Europe. Within the Palaeolithic and Mesolithic periods there are considerable opportunities for pioneering research. Individual projects can still have a substantial impact and there remain opportunities for pioneering discoveries including cemeteries, domestic and other structures, stratified sites, and for exploring the huge evidential potential of water-logged and underwater sites. Palaeolithic and Mesolithic archaeology also stimulates and draws upon exciting multi-disciplinary collaborations. Panel Task and Remit The panel remit was to review critically the current state of knowledge and consider promising areas of future research into the earliest prehistory of Scotland. This was undertaken with a view to improved understanding of all aspects of the colonization and inhabitation of the country by peoples practising a wholly hunter-fisher-gatherer way of life prior to the advent of farming. In so doing, it was recognised as particularly important that both environmental data (including vegetation, fauna, sea level, and landscape work) and cultural change during this period be evaluated. The resultant report, outlines the different areas of research in which archaeologists interested in early prehistory work, and highlights the research topics to which they aspire. The report is structured by theme: history of investigation; reconstruction of the environment; the nature of the archaeological record; methodologies for recreating the past; and finally, the lifestyles of past people – the latter representing both a statement of current knowledge and the ultimate aim for archaeologists; the goal of all the former sections. The document is reinforced by material on-line which provides further detail and resources. The Palaeolithic and Mesolithic panel report of ScARF is intended as a resource to be utilised, built upon, and kept updated, hopefully by those it has helped inspire and inform as well as those who follow in their footsteps. Future Research The main recommendations of the panel report can be summarized under four key headings:  Visibility: Due to the considerable length of time over which sites were formed, and the predominant mobility of the population, early prehistoric remains are to be found right across the landscape, although they often survive as ephemeral traces and in low densities. Therefore, all archaeological work should take into account the expectation of Palaeolithic and Mesolithic ScARF Panel Report iv encountering early prehistoric remains. This applies equally to both commercial and research archaeology, and to amateur activity which often makes the initial discovery. This should not be seen as an obstacle, but as a benefit, and not finding such remains should be cause for question. There is no doubt that important evidence of these periods remains unrecognised in private, public, and commercial collections and there is a strong need for backlog evaluation, proper curation and analysis. The inadequate representation of Palaeolithic and Mesolithic information in existing national and local databases must be addressed.  Collaboration: Multi-disciplinary, collaborative, and cross- sector approaches must be encouraged – site prospection, prediction, recognition, and contextualisation are key areas to this end. Reconstructing past environments and their chronological frameworks, and exploring submerged and buried landscapes offer existing examples of fruitful, cross-disciplinary work. Palaeolithic and Mesolithic archaeology has an important place within Quaternary science and the potential for deeply buried remains means that geoarchaeology should have a prominent role.  Innovation: Research-led projects are currently making a substantial impact across all aspects of Palaeolithic and Mesolithic archaeology; a funding policy that acknowledges risk and promotes the innovation that these periods demand should be encouraged. The exploration of lesser known areas, work on different types of site, new approaches to artefacts, and the application of novel methodologies should all be promoted when engaging with the challenges of early prehistory.  Tackling the ‘big questions’: Archaeologists should engage with the big questions of earliest prehistory in Scotland, including the colonisation of new land, how lifestyles in past societies were organized, the effects of and the responses to environmental change, and the transitions to new modes of life. This should be done through a holistic view of the available data, encompassing all the complexities of interpretation and developing competing and testable models. Scottish data can be used to address many of the currently topical research topics in archaeology, and will provide a springboard to a better understanding of early prehistoric life in Scotland and beyond.
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Aharoni, Asaph, Zhangjun Fei, Efraim Lewinsohn, Arthur Schaffer, and Yaakov Tadmor. System Approach to Understanding the Metabolic Diversity in Melon. United States Department of Agriculture, July 2013. http://dx.doi.org/10.32747/2013.7593400.bard.

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Fruit quality is determined by numerous genetic factors that affect taste, aroma, ‎color, texture, nutritional value and shelf life. To unravel the genetic components ‎involved in the metabolic pathways behind these traits, the major goal of the project was to identify novel genes that are involved in, or that regulate, these pathways using correlation analysis between genotype, metabolite and gene expression data. The original and specific research objectives were: (1) Collection of replicated fruit from a population of 96 RI lines derived from parents distinguished by great diversity in fruit development and quality phenotypes, (2) Phenotypic and metabolic profiling of mature fruit from all 96 RI lines and their parents, (3) 454 pyrosequencing of cDNA representing mRNA of mature fruit from each line to facilitate gene expression analysis based on relative EST abundance, (4) Development of a database modeled after an existing database developed for tomato introgression lines (ILs) to facilitate online data analysis by members of this project and by researchers around the world. The main functions of the database will be to store and present metabolite and gene expression data so that correlations can be drawn between variation in target traits or metabolites across the RI population members and variation in gene expression to identify candidate genes which may impact phenotypic and chemical traits of interest, (5) Selection of RI lines for segregation and/or hybridization (crosses) analysis to ascertain whether or not genes associated with traits through gene expression/metabolite correlation analysis are indeed contributors to said traits. The overall research strategy was to utilize an available recombinant inbred population of melon (Cucumis melo L.) derived from phenotypically diverse parents and for which over 800 molecular markers have been mapped for the association of metabolic trait and gene expression QTLs. Transcriptomic data were obtained by high throughput sequencing using the Illumina platform instead of the originally planned 454 platform. The change was due to the fast advancement and proven advantages of the Illumina platform, as explained in the first annual scientific report. Metabolic data were collected using both targeted (sugars, organic acids, carotenoids) and non-targeted metabolomics analysis methodologies. Genes whose expression patterns were associated with variation of particular metabolites or fruit quality traits represent candidates for the molecular mechanisms that underlie them. Candidate genes that may encode enzymes catalyzingbiosynthetic steps in the production of volatile compounds of interest, downstream catabolic processes of aromatic amino acids and regulatory genes were selected and are in the process of functional analyses. Several of these are genes represent unanticipated effectors of compound accumulation that could not be identified using traditional approaches. According to the original plan, the Cucurbit Genomics Network (http://www.icugi.org/), developed through an earlier BARD project (IS-3333-02), was expanded to serve as a public portal for the extensive metabolomics and transcriptomic data resulting from the current project. Importantly, this database was also expanded to include genomic and metabolomic resources of all the cucurbit crops, including genomes of cucumber and watermelon, EST collections, genetic maps, metabolite data and additional information. In addition, the database provides tools enabling researchers to identify genes, the expression patterns of which correlate with traits of interest. The project has significantly expanded the existing EST resource for melon and provides new molecular tools for marker-assisted selection. This information will be opened to the public by the end of 2013, upon the first publication describing the transcriptomic and metabolomics resources developed through the project. In addition, well-characterized RI lines are available to enable targeted breeding for genes of interest. Segregation of the RI lines for specific metabolites of interest has been shown, demonstrating the utility in these lines and our new molecular and metabolic data as a basis for selection targeting specific flavor, quality, nutritional and/or defensive compounds. To summarize, all the specific goals of the project have been achieved and in many cases exceeded. Large scale trascriptomic and metabolomic resources have been developed for melon and will soon become available to the community. The usefulness of these has been validated. A number of novel genes involved in fruit ripening have been selected and are currently being functionally analyzed. We thus fully addressed our obligations to the project. In our view, however, the potential value of the project outcomes as ultimately manifested may be far greater than originally anticipated. The resources developed and expanded under this project, and the tools created for using them will enable us, and others, to continue to employ resulting data and discoveries in future studies with benefits both in basic and applied agricultural - scientific research.
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