Dissertations / Theses on the topic 'Novel Human Protein Family'
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Cloonan, Nicole, and N/A. "Sin1 and Sin1 Isoforms: An Investigation into the Biological Significance of a Novel Human Protein Family." Griffith University. School of Biomolecular and Biomedical Science, 2006. http://www4.gu.edu.au:8080/adt-root/public/adt-QGU20071102.150237.
Full textCloonan, Nicole. "Sin1 and Sin1 Isoforms: An Investigation into the Biological Significance of a Novel Human Protein Family." Thesis, Griffith University, 2006. http://hdl.handle.net/10072/367210.
Full textThesis (PhD Doctorate)
Doctor of Philosophy (PhD)
School of Biomolecular and Biomedical Sciences
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Nilsson, Jonas. "The LRIG-family : identification of novel regulators of ErbB signaling with clinical implications in astrocytoma /." Doctoral thesis, Umeå : Department of Radiation Sciences, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-783.
Full textBartee, Eric Carter. "Discovery and characterization of a novel family of human ubiquitin ligases termed Membrane Associated RING-CH (MARCH) proteins." Oregon Health & Science University, 2007. http://content.ohsu.edu/u?/etd,629.
Full textMolecular Microbiology and Immunology
Both poxviruses and γ2-herpesviruses share the K3-family of viral immune evasion proteins. These proteins are characterized by an amino-terminal RING-CH domain followed by two transmembrane domains. We analyzed several human homologues of the K3-family termed membrane-associated RING-CH (MARCH) proteins. All MARCH proteins localized to subcellular membranes while several reduced surface levels of known K3-family substrates. Thus, MARCH proteins appear to be structurally and functionally homologous to viral K3 proteins. One of the major challenges in determining the function of this family is the identification of their physiological substrates. To overcome this we created a quantitative proteomics approach which can be used to identify novel substrates for both the K3- and MARCH-families. Using stable isotope labeling by amino acids in cell culture, we compared the proteome of plasma membrane, golgi, and endoplasmic reticulum membranes in the presence and absence of K5 and MARCH-VIII. Quantitative mass spectrometric protein identification from these fractions revealed that CD316 (bone marrow stromal antigen 2), CD166 (activated leukocyte cell adhesion molecule) and syntaxin-4 were consistently underrepresented in the plasma membrane of K5 expressing cells, while CD44, CD81 (TAPA-1) and B-cell receptor-associated protein 31kDa (Bap31) were consistently underrepresented in the plasma membrane of MARCH-VIII expressing cells. Furthermore, downregulation of each of these proteins was independently confirmed. Our results both identify and characterize a novel family of human ubiquitin ligase enzymes and elucidate a novel technique which can analyze this family and be easily adapted to the analysis of other cellular enzymes viral immune modulators.
Iwai, Akio. "Siah-1L, a novel transcript variant belonging to the human Siah family of proteins, regulates β-catenin activity in a p53-dependent manner." Kyoto University, 2005. http://hdl.handle.net/2433/144711.
Full textRuane, Peter Thomas. "Functional characterisation of human EB protein family member EB2." Thesis, University of Leeds, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.550859.
Full textTemprano, López Ana. "The lipin protein family in human adipocytes: lipid metabolism and obesity." Doctoral thesis, Universitat Rovira i Virgili, 2016. http://hdl.handle.net/10803/398025.
Full textLas lipinas son una familia de fosfatasas de fosfatidato (PAP1) dependientes de Mg2+ evolutivamente conservadas, que generan diacilglicerol para la síntesis de fosfolípidos y triacilglicerol. En mamíferos, la familia consiste en lipina-1, lipina-2, y lipina-3. Mientras en ratones la mutación del gen Lpin1 causa lipodistrofia, las mutaciones deletéreas en el gen LPIN1 en humanos no afectan a la distribución de grasa. Sin embargo, los individuos con diabetes tipo 2 manifiestan niveles reducidos de expresión de LPIN1 y de actividad PAP1. En esta tesis doctoral se estudia la función de las lipinas en el tejido adiposo humano, la adipogénesis y la lipólisis. Descubrimos que la expresión génica y proteica de las lipinas está alterada en el tejido adiposo de individuos con diabetes tipo 2. La depleción de cada miembro de las lipinas en la línea celular humana de preadipocitos del síndrome Simpson–Golabi–Behmel (SGBS), mostró que, a pesar de que los tres miembros tienen un papel en la adipogénesis temprana, los adipocitos deplecionados de lipinas se diferencian y acumulan lípidos neutros, llevándonos a la hipótesis de la existencia de vías alternativas para la síntesis de triacilglicerol en adipocitos humanos cuando la expresión de las lipinas es reprimida. Las lipinas también intervienen en el reciclaje de los ácidos grasos liberados por la vía lipolítica. Tras la inducción de la lipólisis, las lipinas son defosforiladas y se desplazan a la membrana del retículo endoplásmico, donde ejercen su función. Esta activación es inducida por los ácidos grasos liberados, y revertida con albúmina o triacsin C. La depleción de cada lipina en adipocitos SGBS y posterior inducción de la lipólisis, demuestra su papel en el metabolismo de lípidos neutros. En resumen, las lipinas parecen no tener un papel indispensable en la adipogénesis humana pero sí comprometer el reciclaje de ácidos grasos, importante para la homeostasis lipídica.
Lipins are evolutionarily conserved Mg2+-dependent phosphatidate phosphatases (PAP1) that generate diacylglycerol for phospholipid and triacylglycerol synthesis. In mammals the Lipin family consists of lipin-1, lipin-2 and lipin-3. Whereas mutations in the Lpin1 gene cause lipodystrophy in mouse models, LPIN1 deleterious mutations in humans do not affect fat distribution. However, reduced LPIN1 expression and PAP1 activity have been described in participants with type 2 diabetes. In this doctoral thesis we investigate the roles of all lipin family members in human adipose tissue, adipogenesis and lipolysis. We found that adipose tissue gene and protein expression of the lipin family is altered in type 2 diabetes. Depletion of every lipin family member in a human Simpson–Golabi–Behmel syndrome (SGBS) pre-adipocyte cell line showed that even though all members alter early stages of adipogenesis, lipin-silenced cells differentiate and accumulate neutral lipids, pointing to the hypothesis of alternative pathways for triacylglycerol synthesis under repression of lipin expression. Lipins also have a role in the recycling of the fatty acids released by the lipolytic pathway. They become dephosphorylated upon lipolytic induction, and translocate to their active site, the endoplasmic reticulum membrane. This activation is induced by fatty acids and reversed with albumin or triacsin C. Depletion of every lipin member and subsequently stimulation of lipolysis in SGBS adipocytes revealed a role for lipins in neutral lipid metabolism. Overall, our data support that lipins may not have an indispensable role in adipogenesis, but their depletion compromise fatty acid recycling and lipid homeostasis.
Chan, Che-man, and 陳志敏. "Functional study of spike protein of a novel human coronavirus HKU1." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2008. http://hub.hku.hk/bib/B41896932.
Full textChan, Che-man. "Functional study of spike protein of a novel human coronavirus HKU1." Click to view the E-thesis via HKUTO, 2008. http://sunzi.lib.hku.hk/hkuto/record/B41896932.
Full textRhyner, Johannes A. "The human calmodulin gene family and characterization of the calmodulin-like protein /." [S.l.] : [s.n.], 1994. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=10508.
Full textRogi, Tomohiro. "Physiological function of the novel human aminopeptidases belonging to oxytocinase sub-family." Kyoto University, 2002. http://hdl.handle.net/2433/149525.
Full textBedrossian, Anaid. "Structure, Expression and Function of the novel KIND Domain Family Protein very-KIND." Doctoral thesis, kostenfrei, 2008. http://www.opus-bayern.de/uni-wuerzburg/volltexte/2008/2846/.
Full textPalmer, Ruth Helen. "Cloning and characterisation of the PRK family : a novel family of protein kinases related to the PKC superfamily." Thesis, University College London (University of London), 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.321771.
Full textSamuels, Yardena Rachel. "ASPP : a novel family of proteins that specifically regulates the apoptotic function of p53." Thesis, Imperial College London, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.289842.
Full textCrossland, Katherine Louise. "Characterisation of a novel transmembrane protein in primary human CD4+ T-cells." Thesis, University of Newcastle upon Tyne, 2014. http://hdl.handle.net/10443/2573.
Full textLe, Van Son. "The BURP domain protein family of Arabidopsis a novel component related to seed development /." [S.l.] : [s.n.], 2005. http://deposit.ddb.de/cgi-bin/dokserv?idn=979554594.
Full textWong, L. H. Y. "Analysis of the novel Lipid transfer protein Anchored at Membrane contact sites (LAM) family." Thesis, University College London (University of London), 2017. http://discovery.ucl.ac.uk/1560219/.
Full textFisk, Dianna G. "CRP1 : founding member of a novel protein family that functions in organellar gene expression /." view abstract of download file of text, 2000. http://wwwlib.umi.com/cr/uoregon/fullcit?p9987422.
Full textAli, Stuart Alvaro. "Transferrin trojan horses : a novel approach for drug delivery?" Thesis, Brunel University, 1999. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.285047.
Full textSawzdargo, Marek. "Discovery of novel G protein-coupled receptor genes including human GALR3 receptor gene." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape9/PQDD_0003/MQ46146.pdf.
Full textPanetta, Rosemarie. "Human somatostatin receptor 5(hSSTR5) : a novel pituitary selective G protein-coupled receptor." Thesis, McGill University, 1996. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=40419.
Full textQuinn, Caroline Frances. "Human respiratory syncytial virus F protein-induced immunosuppression : structures, mechanisms and novel vaccines." Thesis, Queen's University Belfast, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.602933.
Full textDietrich, Joanna Louise. "Phosphorylation of human platelet cytosolic phospholipase A₂ by the Src-family protein tyrosine kinases." Thesis, University of Cambridge, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.621659.
Full textAl, Gharibi Khalaf. "MMP family protein expression as prognostic biomarkers in human soft tissue sarcoma of extremities." Thesis, University of Manchester, 2012. https://www.research.manchester.ac.uk/portal/en/theses/thesis-title-mmp-family-protein-expression-as-prognostic-biomarkers-in-human-soft-tissue-sarcoma-of-extremities(c99f2355-5c2c-4a0c-bf40-3acace12c94a).html.
Full textWheeler, Louise Claire. "Characterisation of RASAL, a novel Ca'2+-regulated RapGAP of the human GAP1 family." Thesis, University of Bristol, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.393010.
Full textMunton, Richard Paul. "Investigation of protein kinase-A dependant GABAb receptor desensitisation and characterisation of a novel family 3 G-protein coupled receptor." Thesis, University of Bristol, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.398537.
Full textBardien-Kruger, Soraya. "A molecular investigation of the novel gene underlying autosomal dominant retinitis pigmentosa in a South African family." Doctoral thesis, University of Cape Town, 1999. http://hdl.handle.net/11427/26927.
Full textUgarte, Chicote Javier. "Evolution and molecular characterization of uroplakin 3c, a novel human tetraspanin associated uroplakin protein." Doctoral thesis, Universitat Rovira i Virgili, 2016. http://hdl.handle.net/10803/387313.
Full textLas uroplaquinas (UPKs) son unas proteínas integrales de membrana que forman las placas del urotelio. Indistintamente de que estas placas se encuentran solamente en el urotelio de mamíferos, las UPKs también existen en vertebrados inferiores que carecen de urotelio. Las UPKs pueden ser divididas en dos tipos, por un lado UPK1a y UPK1b, quepertenecen a la familia de las tetraspaninas y por otro lado las uropalkinas UPK2/3 (UPK2, UPK3a y UPK3b), que atraviesan la membrana solo una vez y de las cuales se desconoce que estén relacionadas evolutivamente con otras familias de proteínas. Nosotros, hemos identificado 3 nuevos ortólogos de las UPK2/3 (UPK3c que se expresa en humanos, UPK2b y UPK3d); localizado el origen de las UPKs en el ancestro común de vertebrados; encontrado una relación evolutiva entre UPK2/3s y llas tirosina fosfatasas (R3 PTPRs) que son proteínas más antiguas;analizado la expansión de los loci genéticos de UPK3c y las duplicaciones segmentales que tuvieron lugar en gorila, chimpancé y humano, y encontrado que posiblemente la transposición intracromosomal de una de las duplicaciones segmentales se produjese a través de un intermediario circular. Mediante el uso de técnicas de biología molecular, hemos encontrado que UPK3c se expresada en un amplio rango de tejidos huamnos predominantemente en cornea. Además, hemos observado que UPK3c está N-glicosilada en cornea humana, pterigion y en tumores de vejiga; que UPK3c se localiza predominantemente en las capas basal e intermedia del urotelio de ratón y no se encuentra en las placas del urotelio. En muestras de tumores de vejiga humanos, pudimos observar que el numero de tumores que expresan UPK3c es mayor en tumores superficiales de bajo grado (9/11) y disminuye en los tumores de alto grado (6/11) y en los invasivos (3/9).
Uroplakins (UPKs) are integral membrane proteins that form the urothelial plaques. Despite the fact that these plaques are unique to the urinary bladder of mammals, UPKs also exist in lower vertebrates without a typical urothelium. Uroplakins can be divided into two types. UPK1a and UPK1b, which belong to the tetraspanin family and UPK2/3 uroplakins that comprises UPK2, UPK3a and UPK3b, span the membrane only once and are not known to be related to any other protein family. We have identify three novel UPK2/3 ortholog groups (UPK3c that is expressed in humans, UPK2b and UPK3d), report the origin of UPKs in the common ancestor of vertebrates and the evolutionary relationship between UPK2/3s and the more ancient tyrosine phosphatase receptors (R3 PTPRs). The joint expansion of the UPK3c genetic loci and segmental duplications in the gorilla, chimpanzee and homo and we found that intrachromosomal transposition of one of these segmental duplication could have been produced by a circular intermediate Using molecular biology techniques we found UPK3c expression widespread in human tissues, particularly strong in corneal tissue. Additionally, UPK3c is N-glycosilated in human normal corneal tissue, pterygium and bladder tumors; localizes predominately to the basal and intermediate cell layers of the mouse urothelium and is absent in the urothelial plaques. Finally in human bladder cancer the number of superficial low grade tumors expressing UPK3c assessed by immunoblot was higher than in superficial superficial high grade tumors or invasive tumors .
Collins-De, Peyer Laurence. "Screening of a rat thymus and a human hippocampus cDNA library for a novel fyn-related oncogene." Thesis, Hong Kong : University of Hong Kong, 1999. http://sunzi.lib.hku.hk/hkuto/record.jsp?B21253870.
Full textKharalkar, Shilpa S. "Identification of Novel Allosteric Regulators of Human Erythrocyte Pyruvate Kinase." VCU Scholars Compass, 2006. http://hdl.handle.net/10156/2083.
Full textGarami, Elizabeth. "Initial characterization of a novel human retinal gene encoding a putative Pleckstrin homology domain protein." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1995. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/MQ45438.pdf.
Full textChen, Bin, and 陈斌. "Structural and functional characterization of human APPL2, a novel adaptor protein involved in insulin signaling." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B4552757X.
Full textLi, Hung-sing, and 李鴻陞. "Identification of polycomb group protein CBX8 as a novel tumor suppressor in human colorectal cancer." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/197534.
Full textpublished_or_final_version
Surgery
Master
Master of Philosophy
Al-Mahmoud, Widad Abdulsamad Mansour. "Novel variants of the DNA damage checkpoint protein Hus1 in fission yeast and human cells." Thesis, Bangor University, 2014. https://research.bangor.ac.uk/portal/en/theses/novel-variants-of-the-dna-damage-checkpoint-protein-hus1-in-fission-yeast-and-human-cells(dee8a56b-687f-4f24-9c6d-f81d73edc877).html.
Full textCrosby, David. "Cross-talk between tyrosine kinases and members of the protein kinase C family in human platelets." Thesis, University of Bristol, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.288410.
Full textLaitinen, Saara. "Family of human oxysterol binding protein homologues : ORP2 is a new regulator of cellular lipid metabolism." Helsinki : University of Helsinki, 2002. http://ethesis.helsinki.fi/julkaisut/laa/kansa/vk/laitinen/.
Full textMills, Elena Claire. "Characterisation of the trypanosomatid PPEF-like phosphatases : novel members of the RDGC/PP5-related protein phosphatase family." Thesis, Imperial College London, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.423156.
Full textBromley, Elizabeth Verity. "Characterisation of a novel protein belonging to the WD repeat family in the protozoan parasite Trypanosoma cruzi." Thesis, London School of Hygiene and Tropical Medicine (University of London), 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.289740.
Full textWeir, Marion. "Novel Mechanisms Governing Autoregulation of the Src Family Kinase Fyn and its Crosstalk with Protein Kinase A." ScholarWorks @ UVM, 2016. http://scholarworks.uvm.edu/graddis/592.
Full textChen, Chao-Min Amy. "Identification and characterization of I-mf, a novel myogenic repressor that interacts with MyoD family members /." Thesis, Connect to this title online; UW restricted, 1996. http://hdl.handle.net/1773/5060.
Full textAdair, Richard. "Investigation of protein products encoded by the human cytomegalovirus US22 family genes UL23, UL24, UL43, and US22." Thesis, University of Glasgow, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.392456.
Full textMcKay, Paul Francis. "Cloning of the cDNA for gp200-MR6 : a novel member of the human macrophage mannose receptor family." Thesis, Imperial College London, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.369208.
Full textShikhagaie, Medya. "Characterization of UL1, a member of the human cytomegalovirus RL11 gene family." Doctoral thesis, Universitat Pompeu Fabra, 2011. http://hdl.handle.net/10803/53580.
Full textEn aquest treball hem investigat la pauta oberta de lectura de UL1 del Cytomegalovirus humà (HCMV), el gen UL1 es específic del HCMV. Hem caracteritzat la proteïna UL1 modificada amb un epítop HA en la soca HB5, derivada de AD169. L'UL1 s’expressa com una glicoproteïna que es pot detectar a les 48 i 72h post-infecció. En fibroblasts humans infectats, UL1 co-localitza al citoplasma, al lloc d’assemblatge del virió, amb proteïnes estructurals del virus. A més a més, els anàlisis de virions AD169 purificats que contenen UL1-HA mostren que UL1 és un nou constituent de l’envolta del HCMV. La delecció de UL1 en el context de la soca TB40/E del HCMV disminueix el creixement viral de manera selectiva en determinats tipus cel•lulars, suggerint que UL1 podria estar involucrat en la regulació del tropisme cel•lular del HCMV.
Shobako, Naohisa. "Identification and characterization of a novel anti-hypertensive peptide derived from rice bran protein." Kyoto University, 2019. http://hdl.handle.net/2433/242924.
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新制・課程博士
博士(農学)
甲第21973号
農博第2363号
新制||農||1071(附属図書館)
学位論文||R1||N5224(農学部図書室)
京都大学大学院農学研究科食品生物科学専攻
(主査)教授 井上 和生, 教授 谷 史人, 准教授 大日向 耕作
学位規則第4条第1項該当
Khan, Emad Ali Flood Patrick M. "Characterization of a novel protein - 3D10 - a secreted receptor form of the human osteoclast-associated receptor OSCAR." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2007. http://dc.lib.unc.edu/u?/etd,1374.
Full textTitle from electronic title page (viewed Apr. 25, 2008). "... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the School of Dentistry Curriculum in Oral Biology." Discipline: Oral Biology; Department/School: Dentistry.
Wingate, Ianthe. "Identification of potential novel roles for Hsp70/Hsp90 organising protein (Hop) using proteomic analysis in human cells." Thesis, Rhodes University, 2016. http://hdl.handle.net/10962/64758.
Full textLehman, Jason Alexander. "Novel Redox and DNA-Dependent Conformational Changes in Human Ku, a DNA-Double Strand Break Repair Protein." Wright State University / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=wright1211323245.
Full textBryce, Steven David. "Identification and characterisation of a novel family of human genomic sequences closely related to the Cathepsin L gene." Thesis, University of Newcastle Upon Tyne, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.309763.
Full textWilliams, Marni. "Biochemical and structural characterization of novel drug targets regulating polyamine biosynthesis in the human malaria parasite, Plasmodium falciparum." Thesis, University of Pretoria, 2011. http://hdl.handle.net/2263/26237.
Full textThesis (PhD)--University of Pretoria, 2011.
Biochemistry
unrestricted
Wang-Heaton, Hui. "A novel role of human DNA damage checkpoint protein ATR in suppressing Ca2+ overload-induced PARP1-mediated necrosis." Digital Commons @ East Tennessee State University, 2016. https://dc.etsu.edu/etd/3171.
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