Relevant bibliographies by topics / Novel heterocyclic compounds

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers

Academic literature on the topic 'Novel heterocyclic compounds'

Author: Grafiati
Published: 4 June 2021
Last updated: 6 February 2022

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Journal articles on the topic "Novel heterocyclic compounds"

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Shah, Pranay, R. I. Patel, and P. J. Vyas. "Preparation and Biological Screening of Novel Heterocyclic Compounds." International Journal of Trend in Scientific Research and Development Volume-3, Issue-3 (April 30, 2019): 632–36. http://dx.doi.org/10.31142/ijtsrd22815.

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Olšovská, Jana, Karel Štěrba, Martin Slabý, and Tomáš Vrzal. "Novel method for determination of heterocyclic compounds and their impact in brewing technology." KVASNY PRUMYSL 67, no. 2 (April 15, 2021): 417–27. http://dx.doi.org/10.18832/kp2021.67.417.

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A new simultaneous method for determination of 16 heterocyclic compounds using SPE sample preparation and GC-MS determination was developed regarding increasing interest of the role of sensory active compounds in beer. LiChrolut® EN SPE columns proved to be optimal for both, a mixture of analytes with a different polarity and such complicated matrix as beer. Recoveries of individual analytes are about 100% except for three compounds (2-methylpyridine about 30%, maltol and furaneol about 50%); repeatability, uncertainty and LOQ are satisfactory for the method application. The method was used for monitoring of heterocyclic compounds formation during roasting, mashing, hop boiling and fermentation. To summarize, during roasting of malt, the concentration of oxygen heterocycle compounds (OHC) increases more rapidly in comparison with nitrogen heterocycles compounds (NHC) till a critical point where OHC starts to decrease and NHC starts to be formed sharper (with the exception of 2-acetylpyrrole which is similar to OHC). Finally, the total concentration of NHC during fermentation rapidly decreases whilst the OHC concentration is influenced by many factors, e.g., fermentation conditions and yeast strain.
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Ābele, E., R. Ābele, Ļ. Golomba, J. Višņevska, T. Beresņeva, and K. Rubina. "Oximes of Seven-Membered Heterocyclic Compounds Containing One Heteroatom." Latvian Journal of Chemistry 50, no. 3-4 (January 1, 2011): 205–22. http://dx.doi.org/10.2478/v10161-011-0071-7.

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Oximes of Seven-Membered Heterocyclic Compounds Containing One Heteroatom Literature data on the synthesis and structure of azepane, oxepane and thiepane oximes were reviewed. Synthesis of novel heterocycles from oximes of seven-membered heterocycles containing one heteroatom were described. Biological activity of oximes of seven-membered heterocycles with one heteroatom was also reviewed.
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Ābele, E. "Oximes of Seven-Membered Heterocyclic Compounds Containing Two Heteroatoms." Latvian Journal of Chemistry 51, no. 1-2 (January 1, 2012): 83–92. http://dx.doi.org/10.2478/v10161-012-0005-z.

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Oximes of Seven-Membered Heterocyclic Compounds Containing Two Heteroatoms Literature data concerning the synthesis and structure of diazepane, oxazepane and thiazepane oximes were reviewed. Synthesis of novel heterocycles from the oximes of seven-membered heterocycles containing two heteroatoms was described. Biological activity of oximes of seven-membered heterocycles with two heteroatoms was also reviewed.
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Shaikh, Ansar R., Mazahar Farooqui, R. H. Satpute, and Syed Abed. "Overview on Nitrogen containing compounds and their assessment based on ‘International Regulatory Standards’." Journal of Drug Delivery and Therapeutics 8, no. 6-s (December 21, 2018): 424–28. http://dx.doi.org/10.22270/jddt.v8i6-s.2156.

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Heterocyclic compounds have a role in most fields of sciences such as medicinal chemistry, biochemistry also another area of sciences. More than 90% of new drugscontain heterocycles and the interface between chemistry and biology, at which so much new scientific insight, discovery and application is taking place is crossed by heterocyclic compounds. Compounds derived from heterocyclic rings in pharmacy, medicine, agriculture, plastic, polymer and other fields.Most active heterocycles that have shown considerable biological actions as antifungal, anti-inflammatory, antibacterial, anticonvulsant, antiallergic, herbicidal, anticancer activity. There is always a strong need for new and efficient processes in synthesizing of new Heterocycles.Alum have been used as a novel catalyst in the synthesis of Schiff’s bases. Synthesized Schiff’s bases are free from use of ICH class 1 and Class 2 solvents and also free from structural alerts genotoxic impurities. This review highlights on various aspects of heterocyclic compounds with its biological activity & regulatory assessment based on the ‘International Regulatory Standards’. Keywords: Heterocycles. Nitrogen containing compounds Biological activity, History, Regulatory assessment, International Regulatory Standards
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Mohareb, Rafat, and Hanaa Hana. "Synthesis of progesterone heterocyclic derivatives of potential antimicrobial activity." Acta Pharmaceutica 58, no. 1 (March 1, 2008): 29–42. http://dx.doi.org/10.2478/v10007-007-0043-3.

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Synthesis of progesterone heterocyclic derivatives of potential antimicrobial activityThe aim of this work was to synthesize steroidal heterocycles and to elucidate the potential role of these compounds as antimicrobial agents. The synthesis of steroidal heterocycles containing the pyrazole, isoxazole, thiazole, pyrane, pyridine, pyridazine, or benzopyrane ring attached to the pregnene nucleus is reported. Progesterone (1) reacts with dimethyl formamide dimethyl acetal to form enamine2. Heterocyclization of2with hydrazines, hydroxylamine, glycine, ethyl acetoacetate or cyanomethylene afforded novel steroidal heterocyclic derivatives. Thein vitroantimicrobial evaluation showed that all synthesized compounds show activity against the used strains of Gram positive bacteria and fungi.
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Orzeszko, Barbara, Tomasz Świtaj, Anna B. Jakubowska-Mućka, Witold Lasek, Andrzej Orzeszko, and Zygmunt Kazimierczuk. "Tumor Necrosis Factor-α Production-Enhancing Properties of Novel Adamantylalkylthio Derivatives of Some Heterocyclic Compounds." Zeitschrift für Naturforschung B 60, no. 4 (April 1, 2005): 471–75. http://dx.doi.org/10.1515/znb-2005-0419.

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Certain adamantylated heterocycles were previously shown to enhance the secretion of tumor necrosis factor alpha (TNF-α) by murine melanoma cells that have been transduced with the gene for human TNF-α and constitutively expressed this cytokine. The stimulatory potency of those compounds depended, among other factors, on the structure of the linker between the adamantyl residue and the heterocyclic core. In the present study, a series of (1-adamantyl)alkylsulfanyl derivatives of heterocyclic compounds was prepared by alkylation of the corresponding thioheterocyles. Of the novel adamantylalkylthio compounds tested in the aforementioned cell line, 2-(2-adamantan-1-ylethylsulfanyl)- 4-methyl-pyrimidine was found to be the most active
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Sharma, Praveen Kumar, Andleeb Amin, and M. Kumar. "Synthetic Methods of Medicinally Important Heterocycles-thiazines: A Review." Open Medicinal Chemistry Journal 14, no. 1 (September 14, 2020): 71–82. http://dx.doi.org/10.2174/1874104502014010071.

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Heterocyclic compounds containing N and S atoms have unique properties so that they can be used as potential reactive materials in pharmacokinetic systems. In medicinal chemistry, the therapeutic applications of nitrogen sulphur heterocycles are well known. Especially, Thiazines attract the attention of chemists due to their great bioactive behavior. The present study is a review of the work carried out by the research community for the synthesis of novel, effective, medicinally important heterocyclic compounds-thiazines.
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Doller, Dario, Guiying Li, Robbin M. Brodbeck, and Christian Thomsen. "Novel heterocyclic compounds as mGlu5 antagonists: WO2009015897." Expert Opinion on Therapeutic Patents 20, no. 3 (February 24, 2010): 435–39. http://dx.doi.org/10.1517/13543770903547848.

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Wu, Hsien-Jen, Fang-Jung Huang, and Chu-Chung Lin. "Novel heterocyclic cage compounds from 2-methylthiofurans." Journal of the Chemical Society, Chemical Communications, no. 11 (1991): 770. http://dx.doi.org/10.1039/c39910000770.

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Dissertations / Theses on the topic "Novel heterocyclic compounds"

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MacDonald, Ranald John. "Novel routes to heterocyclic Azo compounds." Thesis, University of Edinburgh, 2011. http://hdl.handle.net/1842/5787.

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The potential use of electron-deficient heterocyclic azo compounds as inkjet dyes was explored. 2-Nitrosopyridine could be used to form a series of azo compounds via the Mills’ reaction with electron-rich aromatic amines. Conditions for this process were optimised by varying solvent and pH. In the presence of ethers, 2-nitrosopyridine is quickly reduced to azoxypyridine. This reaction follows first order kinetics; diethyl and diisopropyl ether react at similar rates, whereas cyclic ethers such as THF are far slower. Organic bases such as Hunigs base were also found to promote formation of azoxypyridine. The mechanism of this reduction was studied. The electrochemistry of 2-nitrosopyridine and azoxypyridine was also explored. Using the optimised conditions for the Mills’ reaction, 2-nitrosopyridine not only reacts with electron-rich amines but also electron-deficient examples. The series was also expanded to include other heterocycles as well as pyridine via the corresponding heterocyclic nitroso compound. Other nitroso compounds prepared were 1- nitrosoisoquinoline, 2-nitrosopyrazine, 4-nitrosopyrimidine and 2-nitrosopyrimidine. The absorption maxima of azo compounds prepared from these precursors were found to correlate with the values for the corresponding azobenzenes. 2-Nitrosopyridine and 2-nitrosopyrimidine react with diamines to give monoazo products. These in turn could be diazotised and coupled with various components to give either bisazo or trisazo compounds. These dyes were tested for their ozone and light fastness properties. The bisazo examples were found to have good ozone fastness but poor light fastness. The pyrimidine examples only showed a slight improvement in ozone and light fastness compared to their pyridine analogue. 2,3-Phthalocyanines are important components in cyan dyes. New routes to precursors of these compounds were explored using flash vacuum pyrolysis (FVP).
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Emans, John. "Synthesis of novel heterocyclic polymers." Thesis, University of St Andrews, 1987. http://hdl.handle.net/10023/15299.

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This work details the synthesis, characterisation and fabrication of a range of copolyesters, containing various angular disrupters, especially disubstituted 2,5-diphenyl- -1,3,4-oxadiazoles. These disrupters were incorporated into the polymers, to reduce the temperature at which the polymers may be processed, to enable their fabrication into fibres. The majority of the polymers prepared were found to be liquid crystalline. However, if the angular disrupter content of the polymer was high, it was found that the resultant polymers were non-liquid crystalline. The polymers were prepared by a melt acidolysis process carried out under a nitrogen flow and subsequently under vacuum, as described in Chapter 3. Eighteen of the polymers were characterised in some detail, though a measure of the relative molecular weights was thought to be of little importance in this work, since all polymers were of a different composition. Differential scanning calorimetry and hot-stage microscopy revealed that several of the polymers had rather unusual melting behaviour. The eighteen polymers that were closely characterised were spun into fibres, using a small melt-spinning apparatus that was designed and produced by Bradford University Research Ltd, The resultant fibres were characterised by differential scanning calorimetry, X-ray diffraction end tensile testing. The general conclusion of the work is that although a reduction in the processing temperature of the polymer is achieved by the incorporation of angular disruptors, which is advantageous, the tensile strength and thermal stability of the fibres produced from such polymers are reduced.
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Nyoni, Dubekile. "Application of the Baylis-Hillman methodology in the construction of novel heterocyclic derivatives." Thesis, Rhodes University, 2008. http://eprints.ru.ac.za/1134/.

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Philbin, Simon Patrick. "Studies of novel nitro-substituted nitrogen heterocyclic compounds." Thesis, Brunel University, 2001. http://bura.brunel.ac.uk/handle/2438/2165.

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The novel candidate high energy insensitive explosive; 2,5-diamino-3,6-dinitropyrazine (ANPZ-i) has been prepared in acceptable overall yield. ANPZ-i was synthesised by the nitration of 2,5-diethoxypyrazine using nitronium tetrafluoroborate (NO2+BF4-) in sulfolane and the subsequent amination of 2,5-diethoxy-3,6-dinitropyrazine, under autoclave conditions. Oxidation studies towards the dioxide derivative of ANPZ-i, 2,5-diamino-3,6-dinitropyrazine-1,4-dioxide (PZDO), were unsuccessful. The synthesis of existing high explosives; 2,6-diamino-3,5-dintropyrazine (ANPZ) and 2,6-diamino-3,5-dinitropyrazine-1-oxide (PZO) has been scaled up to produce approximately 25 g batches of material. A number of novel nitrations using NO2+BF4- have been carried out on a range of chloro-, methyl- and hydroxy-functionalised quinoxalines and quinazolines. A range of novel functionalisations have also been carried out on the platform molecule; 2,4-diamino-6,8-dinitroquinazoline giving rise to 2,4-diamino-6,8-dinitroquinazoline-1,3-dioxide (di-N-oxidation product), 2,4,7-triamino-6,8-dinitroquinazoline (monoamination product) and 2,4,6,8-tetra-aminoquinazoline (dihydrogenation product). Detonics molecular modelling was carried out on the following target molecules: 2,5-diamino-3,6-dinitropyrazine-1,4-dioxide (PZDO), 2,5,8-triamino-3,6,7-trinitroquinoxaline-1-oxide and 2,5,7-triamino-4,6,8-trinitroquinazoline-1-oxide. The detonation velocity of the new explosive molecule; 2,5-diamino-3,6-dinitropyrazine (ANPZ-i) was calculated and it was found to be a similar value to that obtained experimentally for the existing high explosive RDX. Calculation by molecular modelling of the steric energies of ANPZ, PZO, ANPZ-i and PZDO gave a quantitative assessment of the difficulty in oxidising ANPZ-i to give PZDO. Extensive analysis of carbon-13 NMR spectroscopy shift values was carried out for approximately twenty nitrogen heterocyclic compounds. Comparison of shift values indicated consistency in the interpretations. On-line literature searches have shown that the following compounds prepared in this project are new: 2,3,6-trichloro-5-nitroquinoxaline, 2,3-dimethoxy-6,7-dinitroquinoxaline, 2,3,6-trichloroquinoxaline-1-oxide, 2,4-diamino-6,8-dinitroquinazoline-1,3-dioxide, 2,4,7-triamino-6,8-dinitroquinazoline and 2,5-diamino-3,6-dinitropyrazine (ANPZ-i). Furthermore, new synthetic routes have been used in the preparation of the following compounds: 2,3-dichloro-5-nitroquinoxaline, 2,3,6,7-tetrachloro-5-nitroquinoxaline, 2-hydroxy-6-nitroquinoxaline, 2-hydroxy-3-methyl-6-nitroquinoxaline and 2,5-diethoxy-3,6-dinitropyrazine.
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Al-Suwaidan, I. A. "Heterocyclic compounds as novel substrates for glutathione transferase." Thesis, University of Bradford, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.378114.

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Taher, Abutariq. "Novel cyclisations of nitro-compounds for heterocyclic synthesis." Thesis, Loughborough University, 2001. https://dspace.lboro.ac.uk/2134/34705.

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The research described in this thesis is aimed at developing novel methods of synthesis for heterocyclic compounds, in particular cyclisation reactions involving the nitro functional group. The first chapter describes investigations into the Wallach imidazole synthesis. A number of chloroimidazoles were prepared, but the possible extension to highly functionalised imidazoles proved elusive. The second chapter describes studies on the successful conversion of nitroimidazolyl malonates 1 into imidazo[4,5-c]isoxazoles 2, Scheme 1. Related cyclisations are described in chapter three and the thiophene fused isoxazole 3 was successfully prepared. Chapter four investigates the reactivity of the strained imidazo[4,5-c]isoxazole heterocycles. Ring opening of the isoxazole occurred on reaction with phosphines to give iminophosphorane derivatives. Reactions with electron deficient acetylenes led to pyrrolyl imidazoles 4, and a novel [1,4]diazepino[2,3-c]isoxazole 5, Scheme 1, but no reaction was observed with alkenes. [Illustration omitted.] Chapter five entails synthesis of a series of 5-aryl-2H,1H-imidazo[4,5-d][1,2,3]triazole derivatives 7. Triethyl N-1-ethyl-2-methyl-4-nitro-1H-imidazol-5-yl phosphoramidate compound 6 was treated with a range of aryl isocyanates which gave imidazo[4,5-c]triazoles 7 in moderate to good yields. A mechanism involving carbodiimide formation was postulated and was supported using infra-red spectroscopy, Scheme 2. Chapter six reports a new synthesis of 5-aryl-2H indazole derivatives 9 by base catalysed reaction of 2-nitrobenzyl triphenylphosphonium bromide salts 8 with a range of aryl isocyanates. A mechanism of this reaction was proposed and investigated by infra-red spectroscopy, Scheme 3.
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Killoran, P. M. "Development of novel heterocyclic compounds as vascular targeting agents." Thesis, University of Salford, 2015. http://usir.salford.ac.uk/36856/.

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In chapter one the biology of cancer is introduced along with a brief history of drug treatment and the status quo of cancer therapeutics. This includes a general overview of cancer prevalence, carcinogenesis, and biochemistry. The main targets for cancer therapeutics are introduced along with in-depth look at cancer vasculature, tubulin binding agents and their mechanisms of action. In chapter two the development of the routes to the dibenzo[c,e]oxepine target compounds are described. The optimisation of a key biaryl precursor molecule for these analogues is described. This includes a brief overview of palladium catalysed coupling chemistry and a screen for suitable catalytic systems. In chapter three the development of an intramolecular ring closing process for dibenzo[b,d]oxepine is described. This includes investigation into non-phenolic oxidative coupling and a screen for oxidants. Palladium/phosphine catalysed intramolecular arylation is also discussed. In chapter four the synthesis of the target compounds is described along the development of routes to further analogues. In chapter five the biological testing of compounds is discussed. This features an introduction to biological evaluation methods for anti cancer compounds. The results for all of the MTT and tubulin binding assays (MA) are presented, revealing a fluorinated dibenzo[c,e]oxepine analogue with cytotoxicity within the nanomolar range (MTT K562 - IC50 60 nm, MA - 1.2 µM). Furthermore a link has also been established between the cytotoxic activity profiles of a series of simple biaryl compounds and Combretastatin A-4.
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Iannarelli, Paul M. "Routes to novel azo compounds." Thesis, University of Edinburgh, 2008. http://hdl.handle.net/1842/3492.

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Routes to novel heterocyclic azo compounds and components of use as potential inkjet dyes were investigated. A new route to fluorenones from biphenyl acid chlorides using FVP (Flash Vacuum Pyrolysis) has been discovered. Fluorenone and 4-methylfluoren-9-one were prepared by FVP of 2-phenylbenzoyl chloride and 2-methylbiphenyl-2-carbonyl chloride respectively. Xanthen-9-one and thioxanthen-9-one were also prepared by FVP from the corresponding acid chlorides. 9-Phenanthrol could also be prepared via the FVP of biphenylacetyl choride and the application of this method to a heterocylic thiophene system afforded naphtho[1,2-b]thiophen-4-ol. Naphtho[2,1-b]thiophen-4-ol and naphtho[1,2-b]furan- 4-ol could be obtained in low yields by the FVP of (2-thiophen-3-ylphenyl)acetic acid methyl ester and (2-furan-2-ylphenyl) acetic acid methyl ester over a tungsten trioxide catalyst. Coupling of these systems with the diazonium salt of Acid Yellow 9 afforded the corresponding azo compounds. New heterocyclic dyes were also prepared from the condensation of heterocyclic hydrazines with 4,9-disulfophenanthrenequinone. Pyridine, pyridazine, phthalazine, isoquinoline and 2-quinoline disulfophenanthrene quinone metallised 2:1 nickel complexed magenta dyes were prepared. Industrial tests by standard methods revealed the pyridazine dye has a particularly impressive balance of light and ozone fastness over similar magenta dyes. The reaction of an arylnitro compound with 2-aminopyridine appeared to be an attractive and high yielding route to 2-(phenylazo)pyridine. However, application of this reaction to substituted and naphthalene systems failed. This afforded byproducts due to nucleophilic substitution of groups such as methoxy and the relatively uncommon nucleophilic substitution of hydrogen with none of the required azo products obtained. Therefore it appeared that the reaction of a nitro and amine was not a robust and versatile route to heterocyclic azo compounds. An alternate route to heterocyclic azo compounds involved the use of the Mills reaction by the condensation o-anisidine, p-chloroaniline, 2-aminophenol, 3- aminophenol, naphthylamine, 8-amnioquinoline and 2-acetylamino-5-aminobenzenesulfonic acid with 2-nitrosopyridine afforded the heterocyclic azo products in moderate to high yields. The Mills reaction does appear to be the favored route to heterocyclic azo compounds. Several factors were identified which affect the process of bisazo coupling of chromotropic acid and products obtained. Reaction at the ipso position of monoPACAs (2-phenylazochromotropic acid) leading to increased yields of the ipso substitution monoPACA by-product as opposed to the expected bisazo coupling position was a major problem. Studies indicated reactivity at the ipso position was greatly reduced by the presence of electron withdrawing groups around the phenyl ring of the monoPACA. Further study indicated reaction at the bisazo coupling position increased with the strength of the diazonium salt used in bisazo coupling. Therefore the electronic nature of the monoPACA starting material and the diazonium salt used in bisazo coupling greatly affected the products obtained. Reaction pH studies also revealed attack at the bisazo coupling position increases with pH and at lower pH (5.0 – 8.0) attack at the ipso position dominated. Reactivity of the monoPACA starting material also increased with pH. The influence of steric effects upon bisazo coupling revealed, in the cases where ortho sulfonic acid groups were present in the monoPACA, a reduction in attack at the ipso position. Hence the reaction appeared to be directed towards the required bisazo coupling position.
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Rogers, James William. "1-benzotriazolyl-2-propynones as novel 1,3-biselectrophiles, benzotriazole-assisted thioacylation and synthesis of energetic materials." [Gainesville, Fla.] : University of Florida, 2006. http://purl.fcla.edu/fcla/etd/UFE0013389.

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Grisle, Roger Anthony. "Synthesis of novel heterocyclic difluoro monomers via the chemistry of reissert compounds." Thesis, This resource online, 1992. http://scholar.lib.vt.edu/theses/available/etd-05042010-020216/.

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Books on the topic "Novel heterocyclic compounds"

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Andrews, Colan Leslie. The synthesis of some novel fluorinated heterocyclic compounds from fluorinated olefinic precursors. Birmingham: University of Birmingham, 1992.

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Perry, Philip J. Synthesis and biological evaluation of novel cytotoxic heterocyclic compounds: Furo (2,3-b) naphthoquinones and 2-aryl-4H-3,1-benzoxazin-4-ones. Leicester: De Montfort University, 1996.

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Badyal, Karanbir. The use of organotellurium heterocycles as precursors for novel organometallic compounds. Birmingham: Aston University. Department of Chemical Engineering and Applied Chemistry, 1996.

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Cato, Stephen John. Studies of novel heterocyclic polymers. 1987.

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Shawcross, Andrew Paul. The synthesis of novel heterocyclic compounds and observations on the Vilsmeier reaction. 1989.

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Duell, Bradley Lee. Preparation of novel heterocyclic catalysts for the hydrolysis of active phosphorus and carboxylate esters. 1987.

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Al-Suwaidan, Ibrahim A. Heterocyclic compounds as novel substrates for glutathione transferase: The search for new analytical substrates for glutathione transferase.... Bradford, 1987.

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Novel Developments In Stem Cell Mobilization Focus On Cxcr4. Springer, 2012.

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Book chapters on the topic "Novel heterocyclic compounds"

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Barba, Fructuoso. "Electrosynthesis of Heterocyclic Compounds and Other Alternative Electrosynthetic Processes." In Novel Trends in Electroorganic Synthesis, 271–74. Tokyo: Springer Japan, 1998. http://dx.doi.org/10.1007/978-4-431-65924-2_82.

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Wallace, Debra J. "Multiple Ring Closing Metathesis Reactions in the Synthesis of Novel Heterocyclic Compounds." In 19th International Congress on Heterocyclic Chemistry, 85. Elsevier, 2003. http://dx.doi.org/10.1016/b978-0-08-044304-1.50078-2.

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Reddy, Narsimha, Thirupathi Reddy, Nikhil Reddy, Vijayakumar Sonar, and Peter A. "Synthesis and In Vitro Screening of Novel Heterocyclic Compounds as Potential Breast Cancer Agents." In Breast Cancer - Current and Alternative Therapeutic Modalities. InTech, 2011. http://dx.doi.org/10.5772/21838.

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Basu, Anamika. "Enhancing the Therapeutic Efficacy of Flavonoids as Anticancer Drugs Through Novel Drug Delivery Systems." In Advances in Medical Diagnosis, Treatment, and Care, 207–29. IGI Global, 2021. http://dx.doi.org/10.4018/978-1-7998-4453-2.ch009.

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Flavonoids are a group of heterocyclic compounds that are well-known for their anti-cancer activity. Fruits and vegetables are the main dietary sources of flavonoids. Several mechanisms have been proposed for the effect of flavonoids to combat cancer. But before considering the flavonoids as chemotherapeutic drugs for cancer, a number of problems still need to be addressed before their therapeutic uses. Solubility may play a major role in the therapeutic efficacy of flavonoids. Bioavailability of flavonoids are also affected by several other factors. Nanotechnology is the most efficient tool to solve the problems of solubility, stability, and oral bioavailability. Nanotechnology-based drug delivery has several benefits compared to the traditional drug delivery systems. Different types of nano delivery systems are used for producing nanomedicines such as lipid-based nanomedicines, polymer-based nanomedicines, and inorganic nanoparticles. Different types of flavonoids encapsulated nanoparticles have been developed to improve their effectiveness against different types of cancer.
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Coulibaly, Mariame. "Applications of Metal Complexes Dyes in Analytical Chemistry." In Dyes and Pigments - Novel Applications and Waste Treatment. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.95304.

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Trace elements, especially heavy metals, are considered to be one of the main sources of pollution in the environment since they have a significant effect on ecological quality. Commonly, the analytical methods for the determination of trace metals are the spectrometry techniques. While, the electroanalytical methods are recognized as a powerful technique for trace metals owing to its remarkable sensitivity, relatively inexpensive instrumentation, ability for multi-element determination at trace and ultra trace level. New alternative electrode materials are highly desired to develop sensitive stripping sensors for meeting the growing demands for on-site environmental monitoring. Dyes aromatic heterocyclic compound, used in food, textile and cosmetic industries has been used for spectrophotometric determination of metals. In electrochemitry, methods for metals determination based on their complexation with dyes were proposed. In this chapter, a brief summary of spectrometry methods and electrochemical sensors for heavy metals detection based on the formation of metals dyes complexes is presented.
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Conference papers on the topic "Novel heterocyclic compounds"

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Hussein, Ola, Feras Alali, Ala-Eddin Al Moustafa, and Ashraf Khalil. "Design, Synthesis and Biological Evaluation of Novel Chalcone Analogs as Potential Therapeutic Agents for Castration-Resistant Prostate Cancer." In Qatar University Annual Research Forum & Exhibition. Qatar University Press, 2020. http://dx.doi.org/10.29117/quarfe.2020.0179.

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Prostate cancer (PCa) is the second most frequently diagnosed malignancy, as well as a leading cause of cancer-related mortality in men globally. Despite the initial response to hormonal targeted therapy, the majority of patients ultimately progress to a lethal form of the disease, termed as castration-resistant prostate cancer (CRPC), which currently lacks curative therapeutic options and is associated with poor prognosis. Therefore, the development of novel treatment modalities for PCa is urgently needed. Chalcones, also known as 1,3-diphenyl-2-propen-1-ones, are among the highly attractive scaffolds being investigated for their antitumor activities. Three series of 18 cyclic (tetralone-based) and two acyclic chalcone analogs, in which ring B was either substituted with nitrogen mustard or replaced by pyrrole or pyridine heterocyclic rings, were designed, synthesized and evaluated as potential therapies for CRPC. Compounds were synthesized by Claisen-Schmidt condensation reaction, purified using columnchromatography or recrystallization and characterized by 1H-NMR, 13C-NMR and LC-MS. The compounds' in-vitro cytotoxicity was evaluated against three prostate cancer cell lines (PC3, DU145, and LNCaP). Among the tested compounds, OH14, OH19 and OH22 showed potent antiproliferative activities at low micromolar levels with IC50 values ranging between 4.4 and 10 µM against PC3 and DU145 cell lines. Detailed biological studies of the lead molecule OH19 revealed that it significantly induces apoptosis through upregulation of Bax and downregulation of BCL-2. In addition, OH19 potently inhibits colony formation and reduces cell migration of androgen-independent PCa cell lines (PC3 and DU145). The molecular pathway analysis show that the anticancer activity of OH19 is associated with attenuation in the phosphorylation of Akt and ERK. Furthermore, OH19 inhibits blood vessel formation in the chick chorioallantoic membrane (CAM) model as compared to control. These results indicate that OH19 could serve as a potential promising lead molecule for the treatment of CRPC and thus, further in-vitro and invivo studies are warranted.
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