Journal articles on the topic 'Notch'
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Yuan, Xiyu, Xue Hu, Yating Zheng, and Mengli Huang. "Abstract 5095: Investigation of NOTCH mutation and correlation with immunotherapy biomarker in Chinese colorectal cancer patients." Cancer Research 82, no. 12_Supplement (June 15, 2022): 5095. http://dx.doi.org/10.1158/1538-7445.am2022-5095.
Full textRojas, Katerin Ingrid, M. Rocio Martín, Federico Rojo, Angelo Gámez-Pozo, Francisco J. De Castro, Elena Filipovich, Jaime Ceballos, M. Rosario Hernández, and Jose Ales-Martinez. "Transcriptomic mapping on Notch signaling in A luminal phenotype breast cancer." Journal of Clinical Oncology 39, no. 15_suppl (May 20, 2021): e12539-e12539. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.e12539.
Full textPross, Seth, John M. Millholland, Hong Sai, Andrew P. Weng, Jon C. Aster, Warren S. Pear, and Ivan Maillard. "Efficient Inhibition of Notch3 and Notch4 Family Members In Vivo by a Dominant Negative Mutant of Mastermind." Blood 104, no. 11 (November 16, 2004): 1617. http://dx.doi.org/10.1182/blood.v104.11.1617.1617.
Full textShah, Heer, Mittal Mistry, Nupur Patel, and Hemangini Vora. "Clinical significance of Notch receptors in triple negative breast cancer." Breast Disease 42, no. 1 (March 21, 2023): 85–100. http://dx.doi.org/10.3233/bd-220041.
Full textHubmann, Rainer, Martin Hilgarth, Susanne Schnabl, Elena Ponath, Dita Demirtas, Marlies Reiter, Ulrich Jäger, and Medhat Shehata. "Differential Expression and Functions of NOTCH Family Members and Involvement of NR4A1 in the Regulation of Apoptosis in CLL." Blood 120, no. 21 (November 16, 2012): 3919. http://dx.doi.org/10.1182/blood.v120.21.3919.3919.
Full textIto, T., N. Udaka, T. Yazawa, K. Okudela, H. Hayashi, T. Sudo, F. Guillemot, R. Kageyama, and H. Kitamura. "Basic helix-loop-helix transcription factors regulate the neuroendocrine differentiation of fetal mouse pulmonary epithelium." Development 127, no. 18 (September 15, 2000): 3913–21. http://dx.doi.org/10.1242/dev.127.18.3913.
Full textMizuta, Ikuko, Yumiko Nakao-Azuma, Hideki Yoshida, Masamitsu Yamaguchi, and Toshiki Mizuno. "Progress to Clarify How NOTCH3 Mutations Lead to CADASIL, a Hereditary Cerebral Small Vessel Disease." Biomolecules 14, no. 1 (January 18, 2024): 127. http://dx.doi.org/10.3390/biom14010127.
Full textZanotti, Stefano, and Ernesto Canalis. "Notch Suppresses Nuclear Factor of Activated T Cells (Nfat) Transactivation and Nfatc1 Expression in Chondrocytes." Endocrinology 154, no. 2 (December 21, 2012): 762–72. http://dx.doi.org/10.1210/en.2012-1925.
Full textTakam Kamga, Paul, Giada Dal Collo, Federica Resci, Riccardo Bazzoni, Angela Mercuri, Francesca Maria Quaglia, Ilaria Tanasi, et al. "Notch Signaling Molecules as Prognostic Biomarkers for Acute Myeloid Leukemia." Cancers 11, no. 12 (December 6, 2019): 1958. http://dx.doi.org/10.3390/cancers11121958.
Full textMao, Yongzhong, Shaotao Tang, Li Yang, and Kang Li. "Inhibition of the Notch Signaling Pathway Reduces the Differentiation of Hepatic Progenitor Cells into Cholangiocytes in Biliary Atresia." Cellular Physiology and Biochemistry 49, no. 3 (2018): 1115–23. http://dx.doi.org/10.1159/000493290.
Full textBroner, Esther Channah, Genia Alpert, Udi Gluschnaider, Adi Mondshine, Oz Solomon, Ido Sloma, Rami Rauch, Evgeny Izumchenko, Jon Christopher Aster, and Matti Davis. "AL101 mediated tumor inhibition in notch-altered TNBC PDX models." Journal of Clinical Oncology 37, no. 15_suppl (May 20, 2019): 1064. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.1064.
Full textLachej, Nadežda, Violeta Jonušienė, Augustina Mažeikė, Aušra Sasnauskienė, Daiva Dabkevičienė, Julija Šimienė, Kęstutis Sužiedėlis, and Janina Didžiapetrienė. "Changes in the expression of Notch and Wnt signalling molecules in human endometrial cancer." Acta medica Lituanica 26, no. 3 (January 11, 2020): 181–90. http://dx.doi.org/10.6001/actamedica.v26i3.4148.
Full textTakam Kamga, Paul, Federica Resci, Giada Dal Collo, Annalisa Adamo, Riccardo Bazzoni, Angela Mercuri, Massimiliano Bonifacio, and Mauro Krampera. "Prognostic Impact of Notch Signaling in Acute Myeloid Leukemia (AML)." Blood 132, Supplement 1 (November 29, 2018): 5242. http://dx.doi.org/10.1182/blood-2018-99-118701.
Full textHaider, Sandra, Gudrun Meinhardt, Philipp Velicky, Gerlinde R. Otti, Guy Whitley, Christian Fiala, Jürgen Pollheimer, and Martin Knöfler. "Notch Signaling Plays a Critical Role in Motility and Differentiation of Human First-Trimester Cytotrophoblasts." Endocrinology 155, no. 1 (January 1, 2014): 263–74. http://dx.doi.org/10.1210/en.2013-1455.
Full textMerrill, Marsha J., Nancy A. Edwards, and Russell R. Lonser. "Notch receptor and effector expression in von Hippel-Lindau disease–associated central nervous system hemangioblastomas." Journal of Neurosurgery 115, no. 3 (September 2011): 512–17. http://dx.doi.org/10.3171/2011.5.jns11271.
Full textOkuhashi, Yuki, Mai Itoh, Nobuo Nara, and Shuji Tohda. "Effects of NOTCH Knockdown on the Proliferation and mTOR Signaling of T-ALL and AML Cell Lines." Blood 122, no. 21 (November 15, 2013): 1396. http://dx.doi.org/10.1182/blood.v122.21.1396.1396.
Full textMikheil, Dareen, Kirthana Prabhakar, Tun Lee Ng, Sireesh Teertam, B. Jack Longley, Michael A. Newton, and Vijayasaradhi Setaluri. "Notch Signaling Suppresses Melanoma Tumor Development in BRAF/Pten Mice." Cancers 15, no. 2 (January 14, 2023): 519. http://dx.doi.org/10.3390/cancers15020519.
Full textLiu, Xiaoxia, Qingqing Luo, Yanfang Zheng, Xiaoping Liu, Ying Hu, Weifang Liu, Minglian Luo, Yin Zhao, and Li Zou. "NOTCH4 signaling controls EFNB2-induced endothelial progenitor cell dysfunction in preeclampsia." Reproduction 152, no. 1 (July 2016): 47–55. http://dx.doi.org/10.1530/rep-16-0132.
Full textVan de Walle, Inge, Els Waegemans, Jelle De Medts, Greet De Smet, Magda De Smedt, Sylvia Snauwaert, Bart Vandekerckhove, et al. "Specific Notch receptor–ligand interactions control human TCR-αβ/γδ development by inducing differential Notch signal strength." Journal of Experimental Medicine 210, no. 4 (March 25, 2013): 683–97. http://dx.doi.org/10.1084/jem.20121798.
Full textSeverson, Eric Allan, Shakti Ramkissoon, Sugganth Daniel, Jo-Anne Vergilio, Laurie M. Gay, Julia Andrea Elvin, James Suh, et al. "Association of tumor mutational burden in cutaneous squamous cell carcinoma with genomic alterations in Notch family receptors." Journal of Clinical Oncology 35, no. 15_suppl (May 20, 2017): e13031-e13031. http://dx.doi.org/10.1200/jco.2017.35.15_suppl.e13031.
Full textGiuli, M. V., E. Giuliani, I. Screpanti, D. Bellavia, and S. Checquolo. "Notch Signaling Activation as a Hallmark for Triple-Negative Breast Cancer Subtype." Journal of Oncology 2019 (July 11, 2019): 1–15. http://dx.doi.org/10.1155/2019/8707053.
Full textShaik, Jilani Purusottapatnam, Ibrahim O. Alanazi, Akbar Ali Khan Pathan, Narasimha Reddy Parine, Majid A. Almadi, Nahla A. Azzam, Abdulrahman M. Aljebreen, Othman Alharbi, Mohammad Saud Alanazi, and Zahid Khan. "Frequent Activation of Notch Signaling Pathway in Colorectal Cancers and Its Implication in Patient Survival Outcome." Journal of Oncology 2020 (March 9, 2020): 1–8. http://dx.doi.org/10.1155/2020/6768942.
Full textKakuda, Shinako, Rachel K. LoPilato, Atsuko Ito, and Robert S. Haltiwanger. "Canonical Notch ligands and Fringes have distinct effects on NOTCH1 and NOTCH2." Journal of Biological Chemistry 295, no. 43 (August 19, 2020): 14710–22. http://dx.doi.org/10.1074/jbc.ra120.014407.
Full textDemitrack, Elise S., Gail B. Gifford, Theresa M. Keeley, Nobukatsu Horita, Andrea Todisco, D. Kim Turgeon, Christian W. Siebel, and Linda C. Samuelson. "NOTCH1 and NOTCH2 regulate epithelial cell proliferation in mouse and human gastric corpus." American Journal of Physiology-Gastrointestinal and Liver Physiology 312, no. 2 (February 1, 2017): G133—G144. http://dx.doi.org/10.1152/ajpgi.00325.2016.
Full textWu, Guangyu, Svetlana Lyapina, Indranil Das, Jinhe Li, Mark Gurney, Adele Pauley, Inca Chui, Raymond J. Deshaies, and Jan Kitajewski. "SEL-10 Is an Inhibitor of Notch Signaling That Targets Notch for Ubiquitin-Mediated Protein Degradation." Molecular and Cellular Biology 21, no. 21 (November 1, 2001): 7403–15. http://dx.doi.org/10.1128/mcb.21.21.7403-7415.2001.
Full textHubmann, Rainer, Susanne Schnabl, Mohammad Araghi, Christian Schmidl, André F. Rendeiro, Martin Hilgarth, Dita Demirtas, et al. "Targeting Nuclear NOTCH2 by Gliotoxin Recovers a Tumor-Suppressor NOTCH3 Activity in CLL." Cells 9, no. 6 (June 18, 2020): 1484. http://dx.doi.org/10.3390/cells9061484.
Full textUrata, Yusuke, Wataru Saiki, Yohei Tsukamoto, Hiroaki Sago, Hideharu Hibi, Tetsuya Okajima, and Hideyuki Takeuchi. "Xylosyl Extension of O-Glucose Glycans on the Extracellular Domain of NOTCH1 and NOTCH2 Regulates Notch Cell Surface Trafficking." Cells 9, no. 5 (May 14, 2020): 1220. http://dx.doi.org/10.3390/cells9051220.
Full textLiu, Ren, Xiuqing Li, Anil Tulpule, Yue Zhou, Jeffrey S. Scehnet, Shaobing Zhang, Jong-Soo Lee, Preet M. Chaudhary, Jae Jung, and Parkash S. Gill. "KSHV-induced notch components render endothelial and mural cell characteristics and cell survival." Blood 115, no. 4 (January 28, 2010): 887–95. http://dx.doi.org/10.1182/blood-2009-08-236745.
Full textTran, Ivy T., Ashley R. Sandy, Alexis Carulli, Gloria T. Shan, Vedran Radojcic, Ann Friedman, Amy Shelton, et al. "In Vivo Blockade of Individual Notch Ligands and Receptors Provides a New Targeted Therapeutic Approach In Graft-Versus-Host Disease." Blood 118, no. 21 (November 18, 2011): 819. http://dx.doi.org/10.1182/blood.v118.21.819.819.
Full textKamstrup, Maria R., Lise Mette Rahbek Gjerdrum, Edyta Biskup, Britt Thyssing Lauenborg, Elisabeth Ralfkiaer, Anders Woetmann, Niels Ødum, and Robert Gniadecki. "Notch1 as a potential therapeutic target in cutaneous T-cell lymphoma." Blood 116, no. 14 (October 7, 2010): 2504–12. http://dx.doi.org/10.1182/blood-2009-12-260216.
Full textShanmugam, Vignesh, Jeffrey W. Craig, Laura K. Hilton, Matthew H. Nguyen, Christopher K. Rushton, Kian Fahimdanesh, Scott Lovitch, Ben Ferland, David W. Scott, and Jon C. Aster. "Notch activation is pervasive in SMZL and uncommon in DLBCL: implications for Notch signaling in B-cell tumors." Blood Advances 5, no. 1 (January 5, 2021): 71–83. http://dx.doi.org/10.1182/bloodadvances.2020002995.
Full textShanmugam, Vignesh, Jeffrey W. Craig, Laura K. Hilton, Matthew H. Nguyen, Christopher K. Rushton, Kian Fahimdanesh, Scott Lovitch, Ben Ferland, David W. Scott, and Jon C. Aster. "Notch activation is pervasive in SMZL and uncommon in DLBCL: implications for Notch signaling in B-cell tumors." Blood Advances 5, no. 1 (January 5, 2021): 71–83. http://dx.doi.org/10.1182/bloodadvances.2020002995.
Full textTaghon, Tom, Inge Van de Walle, Els Waegemans, Jelle De Medts, Greet De Smet, Magda De Smedt, Bart Vandekerckhove, et al. "Notch ligands control the human αβ/γδ lineage choice through receptor-specific induction of differential Notch signal strength. (111.29)." Journal of Immunology 188, no. 1_Supplement (May 1, 2012): 111.29. http://dx.doi.org/10.4049/jimmunol.188.supp.111.29.
Full textHadland, Brandon K., Barbara Varnum-Finney, Randall T. Moon, Michael Gustave Poulos, Jason M. Butler, Shahin Rafii, and Irwin D. Bernstein. "Notch Signaling By Either Notch1 or Notch2 Mediates Expansion of AGM-Derived Long-Term HSC Populations in Vitro." Blood 124, no. 21 (December 6, 2014): 2897. http://dx.doi.org/10.1182/blood.v124.21.2897.2897.
Full textBigas, Anna, David I. K. Martin, and Laurie A. Milner. "Notch1 and Notch2 Inhibit Myeloid Differentiation in Response to Different Cytokines." Molecular and Cellular Biology 18, no. 4 (April 1, 1998): 2324–33. http://dx.doi.org/10.1128/mcb.18.4.2324.
Full textXue, Dongyun, Dong Li, Cong Dou, and Junshan Li. "A Comprehensive Bioinformatic Analysis of NOTCH Pathway Involvement in Stomach Adenocarcinoma." Disease Markers 2021 (December 8, 2021): 1–19. http://dx.doi.org/10.1155/2021/4739868.
Full textCanalis, Ernesto, Michele Carrer, Tabitha Eller, Lauren Schilling, and Jungeun Yu. "Use of antisense oligonucleotides to target Notch3 in skeletal cells." PLOS ONE 17, no. 5 (May 10, 2022): e0268225. http://dx.doi.org/10.1371/journal.pone.0268225.
Full textLiu, Qiaoyuan, Chuxi Chen, Yunxuan He, Wenhao Mai, Shipeng Ruan, Yunshan Ning, and Yan Li. "Notch Signaling Regulates the Function and Phenotype of Dendritic Cells in Helicobacter pylori Infection." Microorganisms 11, no. 11 (November 20, 2023): 2818. http://dx.doi.org/10.3390/microorganisms11112818.
Full textLuo, B., J. C. Aster, R. P. Hasserjian, F. Kuo, and J. Sklar. "Isolation and functional analysis of a cDNA for human Jagged2, a gene encoding a ligand for the Notch1 receptor." Molecular and Cellular Biology 17, no. 10 (October 1997): 6057–67. http://dx.doi.org/10.1128/mcb.17.10.6057.
Full textTakeuchi, Hideyuki, Michael Schneider, Daniel B. Williamson, Atsuko Ito, Megumi Takeuchi, Penny A. Handford, and Robert S. Haltiwanger. "Two novel protein O-glucosyltransferases that modify sites distinct from POGLUT1 and affect Notch trafficking and signaling." Proceedings of the National Academy of Sciences 115, no. 36 (August 20, 2018): E8395—E8402. http://dx.doi.org/10.1073/pnas.1804005115.
Full textSun, Yuan, Xue Gao, Jia Liu, Qing-You Kong, Xiao-Wei Wang, Xiao-Yan Chen, Qian Wang, Yi-Fan Cheng, Xiao-Xia Qu, and Hong Li. "Differential Notch1 and Notch2 Expression and Frequent Activation of Notch Signaling in Gastric Cancers." Archives of Pathology & Laboratory Medicine 135, no. 4 (April 1, 2011): 451–58. http://dx.doi.org/10.5858/2009-0665-oa.1.
Full textVercauteren, Suzanne M., and Heather J. Sutherland. "Constitutively active Notch4 promotes early human hematopoietic progenitor cell maintenance while inhibiting differentiation and causes lymphoid abnormalities in vivo." Blood 104, no. 8 (October 15, 2004): 2315–22. http://dx.doi.org/10.1182/blood-2004-01-0204.
Full textJiang, Da, Zhaojian Niu, Jianli Zhang, Yanlei Wang, Liang Shang, Bixun Li, Jun Guo, et al. "Notch family gene mutations associate with high tumor mutational burden in diverse cancers." Journal of Clinical Oncology 37, no. 15_suppl (May 20, 2019): e14616-e14616. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.e14616.
Full textShimizu, Kiyoshi, Shigeru Chiba, Noriko Hosoya, Keiki Kumano, Toshiki Saito, Mineo Kurokawa, Yoshinobu Kanda, Yoshio Hamada, and Hisamaru Hirai. "Binding of Delta1, Jagged1, and Jagged2 to Notch2 Rapidly Induces Cleavage, Nuclear Translocation, and Hyperphosphorylation of Notch2." Molecular and Cellular Biology 20, no. 18 (September 15, 2000): 6913–22. http://dx.doi.org/10.1128/mcb.20.18.6913-6922.2000.
Full textChabanais, Julien, François Labrousse, Alain Chaunavel, Agnès Germot, and Abderrahman Maftah. "POFUT1 as a Promising Novel Biomarker of Colorectal Cancer." Cancers 10, no. 11 (October 30, 2018): 411. http://dx.doi.org/10.3390/cancers10110411.
Full textPark, Sung-Gyoo, San-Heon Park, and Jung-Ah Kang. "Notch1 is an important secondary stimulator for activated B cells (IRM10P.606)." Journal of Immunology 194, no. 1_Supplement (May 1, 2015): 131.4. http://dx.doi.org/10.4049/jimmunol.194.supp.131.4.
Full textParmigiani, Elena, and Claudio Giachino. "Genetic Inactivation of Notch1 Synergizes with Loss of Trp53 to Induce Tumor Formation in the Adult Mouse Forebrain." Cancers 14, no. 21 (November 2, 2022): 5409. http://dx.doi.org/10.3390/cancers14215409.
Full textKrebs, Luke T., Yingzi Xue, Christine R. Norton, John R. Shutter, Maureen Maguire, John P. Sundberg, Daniel Gallahan, et al. "Notch signaling is essential for vascular morphogenesis in mice." Genes & Development 14, no. 11 (June 1, 2000): 1343–52. http://dx.doi.org/10.1101/gad.14.11.1343.
Full textLee, Suk Young, Keiki Kumano, Kumi Nakazaki, Masashi Sanada, Go Yamamoto, Yasuhito Nannya, Ritsuro Suzuki, et al. "Gain-of-Function Mutations and Copy Number Increases of Notch2 in Diffuse Large B-Cell Lymphoma." Blood 110, no. 11 (November 16, 2007): 695. http://dx.doi.org/10.1182/blood.v110.11.695.695.
Full textCrow, Jacob J., and Allan R. Albig. "Notch family members follow stringent requirements for intracellular domain dimerization at sequence-paired sites." PLOS ONE 15, no. 11 (November 24, 2020): e0234101. http://dx.doi.org/10.1371/journal.pone.0234101.
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