Academic literature on the topic 'Notch'
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Journal articles on the topic "Notch"
Yuan, Xiyu, Xue Hu, Yating Zheng, and Mengli Huang. "Abstract 5095: Investigation of NOTCH mutation and correlation with immunotherapy biomarker in Chinese colorectal cancer patients." Cancer Research 82, no. 12_Supplement (June 15, 2022): 5095. http://dx.doi.org/10.1158/1538-7445.am2022-5095.
Full textRojas, Katerin Ingrid, M. Rocio Martín, Federico Rojo, Angelo Gámez-Pozo, Francisco J. De Castro, Elena Filipovich, Jaime Ceballos, M. Rosario Hernández, and Jose Ales-Martinez. "Transcriptomic mapping on Notch signaling in A luminal phenotype breast cancer." Journal of Clinical Oncology 39, no. 15_suppl (May 20, 2021): e12539-e12539. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.e12539.
Full textPross, Seth, John M. Millholland, Hong Sai, Andrew P. Weng, Jon C. Aster, Warren S. Pear, and Ivan Maillard. "Efficient Inhibition of Notch3 and Notch4 Family Members In Vivo by a Dominant Negative Mutant of Mastermind." Blood 104, no. 11 (November 16, 2004): 1617. http://dx.doi.org/10.1182/blood.v104.11.1617.1617.
Full textShah, Heer, Mittal Mistry, Nupur Patel, and Hemangini Vora. "Clinical significance of Notch receptors in triple negative breast cancer." Breast Disease 42, no. 1 (March 21, 2023): 85–100. http://dx.doi.org/10.3233/bd-220041.
Full textHubmann, Rainer, Martin Hilgarth, Susanne Schnabl, Elena Ponath, Dita Demirtas, Marlies Reiter, Ulrich Jäger, and Medhat Shehata. "Differential Expression and Functions of NOTCH Family Members and Involvement of NR4A1 in the Regulation of Apoptosis in CLL." Blood 120, no. 21 (November 16, 2012): 3919. http://dx.doi.org/10.1182/blood.v120.21.3919.3919.
Full textIto, T., N. Udaka, T. Yazawa, K. Okudela, H. Hayashi, T. Sudo, F. Guillemot, R. Kageyama, and H. Kitamura. "Basic helix-loop-helix transcription factors regulate the neuroendocrine differentiation of fetal mouse pulmonary epithelium." Development 127, no. 18 (September 15, 2000): 3913–21. http://dx.doi.org/10.1242/dev.127.18.3913.
Full textMizuta, Ikuko, Yumiko Nakao-Azuma, Hideki Yoshida, Masamitsu Yamaguchi, and Toshiki Mizuno. "Progress to Clarify How NOTCH3 Mutations Lead to CADASIL, a Hereditary Cerebral Small Vessel Disease." Biomolecules 14, no. 1 (January 18, 2024): 127. http://dx.doi.org/10.3390/biom14010127.
Full textZanotti, Stefano, and Ernesto Canalis. "Notch Suppresses Nuclear Factor of Activated T Cells (Nfat) Transactivation and Nfatc1 Expression in Chondrocytes." Endocrinology 154, no. 2 (December 21, 2012): 762–72. http://dx.doi.org/10.1210/en.2012-1925.
Full textTakam Kamga, Paul, Giada Dal Collo, Federica Resci, Riccardo Bazzoni, Angela Mercuri, Francesca Maria Quaglia, Ilaria Tanasi, et al. "Notch Signaling Molecules as Prognostic Biomarkers for Acute Myeloid Leukemia." Cancers 11, no. 12 (December 6, 2019): 1958. http://dx.doi.org/10.3390/cancers11121958.
Full textMao, Yongzhong, Shaotao Tang, Li Yang, and Kang Li. "Inhibition of the Notch Signaling Pathway Reduces the Differentiation of Hepatic Progenitor Cells into Cholangiocytes in Biliary Atresia." Cellular Physiology and Biochemistry 49, no. 3 (2018): 1115–23. http://dx.doi.org/10.1159/000493290.
Full textDissertations / Theses on the topic "Notch"
Maxe, Liza, Kiana Entezarjo, and Douglas Karegren. "Swap Notch." Thesis, Högskolan i Halmstad, Akademin för ekonomi, teknik och naturvetenskap, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:hh:diva-40654.
Full textQuillard, Thibaut. "Importance de la voie Notch dans la dysfonction endothéliale en transplantation : régulation et fonctions des récepteurs Notch2 et Notch4." Nantes, 2008. https://archive.bu.univ-nantes.fr/pollux/show/show?id=6bdde4e3-76bb-4a01-9661-3ee28931b379.
Full textNotch plays major roles in endothelial cells (EC) survival, proliferation and transdifferentiation. These events are particularly implicated in transplant arteriosclerosis (TA). This work aims to define Notch molecules regulation and its functional relevance in graft EC. We first studied Notch family members (receptors, ligands and effectors) regulation during EC activation by cytokines. We show that TNFα induced a switch in Notch expression pattern by a strong down-regulation of Notch4 and an increase in Notch2, respectively dependent on NFkB and PI3K pathways. This effect is associated with a global decrease in CBF1 activity and an opposite regulation of hes1 and hey1. Decrease in EC-restricted Notch4 expression is also associated with TA in a rat cardiac allograft model where TNFα, TGFβ and IL10 are strongly expressed. Inhibition of Notch4 and hes1 by siRNA enhances VCAM1 expression, induces apoptosis and impairs endothelial injury repair, suggesting that Notch4 expression is required to maintain EC survival and quiescence. To study the role of Notch2 in EC, we constructed a recombinant adenovirus for Notch2ICD (N2ICD). Constitutive expression of N2ICD leads to EC apoptosis associated with a drastic repression of pro- (survivin, april) and anti-apoptotic genes (bim, DAPK2, HRK, DR5, CD40). Effect of N2ICD is mainly dependent on survivin inhibition. Accordingly, Notch2 knock-down increases survivin expression and protects EC from anoïkis. Altogether, our results reveal crosstalks between TNF and Notch signaling during endothelial dysfunction, propose a role for Notch4 in preventing TA-related EC dysfunction and for Notch2 role in EC survival through survivin regulation
Huang, Yuchen. "Adaptive Notch Filter." PDXScholar, 1994. https://pdxscholar.library.pdx.edu/open_access_etds/4802.
Full textO'Neill, Christine F. "Notch Regulation of Human Breat Cancer Progression: Contrasting Roles for Notch Signaling." Fogler Library, University of Maine, 2007. http://www.library.umaine.edu/theses/pdf/O'NeillCF2007.pdf.
Full textPoudel, Rajeeb. "Single Notch Versus Multi Notch Credit Rating Changes and the Business Cycle." Thesis, University of North Texas, 2015. https://digital.library.unt.edu/ark:/67531/metadc848118/.
Full textSerafin, Valentina. "Notch3 signalling promotes tumour growth in colorectal cancer: implication for Notch target therapy." Doctoral thesis, Università degli studi di Padova, 2012. http://hdl.handle.net/11577/3422188.
Full textE’ ormai noto da alcuni anni che un’aberrante attivazione della via di segnalazione di Notch gioca un ruolo critico nella patogenesi della leucemia linfoblastica acuta a cellule T (T-ALL) e di alcune neoplasie solide come il cancro del polmone, della mammella e dell’ovaio. Inoltre, una marcata attivazione del recettore Notch1 è stata osservata negli adenomi intestinali ed è correlata all’aumentata espressione del ligando Jagged-1 indotta dall’attivazione del pathway Wnt-APC-β-catenina. E’ stato inoltre dimostrato che questa pathway, insieme a quella di Notch, interviene nella regolazione della proliferazione e del differenziamento delle cellule epiteliali della mucosa intestinale normale. Attualmente, non si sa ancora se altri meccanismi di attivazione della pathway di Notch, oltre a quello ligando-dipendente, siano operativi nel CRC e nemmeno se possano essere coinvolti altri recettori della stessa famiglia. In questo studio, abbiamo cercato di chiarire il possibile coinvolgimento di Notch3 nel CRC. Basandoci sull’osservazione che Notch3 risulta essere frequentemente overespresso sia a livello di mRNA che di proteina nei campioni umani di CRC, abbiamo cercato di chiarire come il recettore Notch3 potesse modulare le proprietà tumorigeniche delle cellule di CRC. A tale scopo, si sono rivelati particolarmente utili alcuni xenotrapianti di cellule umane di CRC che presentano una diversa aggressività in topi NOD/SCID. Infatti, utilizzando i tumori sperimentali, abbiamo potuto dimostrare che l’espressione dei diversi componenti del pathway di Notch risulta essere significativamente elevata nella variante aggressiva rispetto a quella dormiente. In particolare si è osservata un’ aumentata espressione dei ligandi DLL4 e Jagged-1 ed un incremento dei livelli del trascritto di Notch3 e della forma attiva del recettore nei tumori che crescono più rapidamente. Una simile up-regolazione di Notch3 con un’aumentata attivazione della via di segnalazione si è osservata in seguito a stimolazione delle cellule di CRC in vitro con il ligando DLL4 ricombinante. Analogamente, anche l’overespressione di una forma attiva del recettore Notch3 in queste stesse cellule conferisce loro una maggiore capacità proliferativa e favorisce la formazione di tumori in vivo. Al contrario, si è visto che l’inattivazione del pathway mediante silenziamento genico di Notch3 nelle cellule aggressive di CRC, determina significative alterazioni del ciclo cellulare con conseguente riduzione nella proliferazione in vitro e un ritardo nella crescita dei tumori in vivo. Complessivamente, questi risultati dimostrano che il recettore Notch3 può modulare le proprietà tumorigeniche delle cellule di CRC, in particolare contribuendo a mantenere elevata l’attivazione della via di Notch nei tumori esprimenti nel loro microambiente tumorale alti livelli di DLL4. Inoltre, l’inoculo della variante più aggressiva rispetto a quella dormiente per via endovenosa in topi NOD/SCID ha mostrato che le cellule di CRC non hanno solo una diversa capacità tumorigenica, ma anche una differente capacità metastatica a livello polmonare, sia in termine di numero che di dimensioni delle metastasi osservate. Basandoci sui risultati fin qui ottenuti, e su uno studio recentemente pubblicato in cui è stato dimostrato come il pathway di Notch sembra essere coinvolto anche nel processo di metastatizzazione, abbiamo condotto un primo esperimento pilota che prevedeva, in topi portatori di metastasi polmonari, il blocco dei recettori Notch3 e Notch2 mediante l’impiego di un anticorpo neutralizzante. Sfortunatamente i risultati ottenuti non hanno fino ad ora mostrato una riduzione significativa nel numero e nelle dimensioni delle metastasi analizzate: l’analisi dei livelli di alterazione di Notch dopo il trattamento è in corso. A conclusione dello studio le nostre osservazioni rappresentano un punto di partenza per un futuro sviluppo di terapie che abbiano Notch3 come bersaglio per il trattamento di un sottogruppo di casi di CRC.
Rangarao, Kaluri Venkata. "Adaptive digital notch filtering." Thesis, Monterey, California. Naval Postgraduate School, 1991. http://hdl.handle.net/10945/26345.
Full textSingh, Nita. "The expression of the Notch receptors, Notch ligands, and the Fringe genes in hematopoiesis." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp04/mq29262.pdf.
Full textFerreira, António Carlos Ribeiro. "Notch signaling pathway in gastric carcinogenesis: E-cadherin inactivation on Noth-dependent cell survival." Doctoral thesis, Faculdade de Medicina da Universidade do Porto, 2010. http://hdl.handle.net/10216/55364.
Full textFerreira, António Carlos Ribeiro. "Notch signaling pathway in gastric carcinogenesis: E-cadherin inactivation on Noth-dependent cell survival." Tese, Faculdade de Medicina da Universidade do Porto, 2010. http://hdl.handle.net/10216/55364.
Full textBooks on the topic "Notch"
Simpson, Pat. The notch receptors. Austin: R.G. Landes Co., 1994.
Find full textBellen, Hugo J., and Shinya Yamamoto, eds. Notch Signaling. New York, NY: Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4939-1139-4.
Full textYasutomo, Koji, ed. Notch Signaling. Singapore: Springer Singapore, 2017. http://dx.doi.org/10.1007/978-981-10-4971-2.
Full textKoenig, Joseph. Smugglers notch. Bath, England: Chivers Press, 1991.
Find full textPinkham's Notch. Porthsmouth, N.H: P.E. Randall Publisher, 1998.
Find full textKoenig, Joseph. Smuggler's notch. New York: Viking, 1989.
Find full textNotch signaling: Methods and protocols. New York: Humana Press, 2014.
Find full textJia, Dongyu, ed. Notch Signaling Research. New York, NY: Springer US, 2022. http://dx.doi.org/10.1007/978-1-0716-2201-8.
Full textNotch ear's sacrifice. Evergreen, CO: Todd Lederman, 2009.
Find full textOne last notch. London: Robert Hale, 2005.
Find full textBook chapters on the topic "Notch"
Park, Gibeom, and Woong-Yang Park. "Notch (Notch1, Notch2, Notch3, Notch4)." In Encyclopedia of Signaling Molecules, 3554–62. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-67199-4_509.
Full textHorstkorte, Rüdiger, Bettina Büttner, Kaya Bork, Navdeep Sahota, Sarah Sabir, Laura O’Regan, Joelle Blot, et al. "Notch (Notch1, Notch2, Notch3, Notch4)." In Encyclopedia of Signaling Molecules, 1254–61. New York, NY: Springer New York, 2012. http://dx.doi.org/10.1007/978-1-4419-0461-4_509.
Full textWeik, Martin H. "notch." In Computer Science and Communications Dictionary, 1117. Boston, MA: Springer US, 2000. http://dx.doi.org/10.1007/1-4020-0613-6_12548.
Full textClausen, Torben, José Luis Trejo, Mark P. Mattson, Alexis M. Stranahan, Joanna Erion, Rosa Maria Bruno, Stefano Taddei, and Melinda M. Manore. "Notch." In Encyclopedia of Exercise Medicine in Health and Disease, 648. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-540-29807-6_3207.
Full textHozumi, Katsuto. "Notch Ligands for Lymphocyte Development." In Notch Signaling, 3–20. Singapore: Springer Singapore, 2017. http://dx.doi.org/10.1007/978-981-10-4971-2_1.
Full textMaekawa, Yoichi, Takahide Ikeda, and Piyarat Srinontong. "Notch Controls the Differentiation and Function of Cytotoxic CD8 T Cells." In Notch Signaling, 21–33. Singapore: Springer Singapore, 2017. http://dx.doi.org/10.1007/978-981-10-4971-2_2.
Full textIshifune, Chieko, and Koji Yasutomo. "Notch and Myeloid Cells." In Notch Signaling, 35–55. Singapore: Springer Singapore, 2017. http://dx.doi.org/10.1007/978-981-10-4971-2_3.
Full textHelbig, Christina, and Derk Amsen. "Taking CD4 T Cells Up a Notch." In Notch Signaling, 57–75. Singapore: Springer Singapore, 2017. http://dx.doi.org/10.1007/978-981-10-4971-2_4.
Full textChiba, Shigeru. "NOTCH in Malignant Lymphoma." In Notch Signaling, 79–92. Singapore: Springer Singapore, 2017. http://dx.doi.org/10.1007/978-981-10-4971-2_5.
Full textNowell, Craig S., and Freddy Radtke. "The Two Faces of Notch in Solid Cancers." In Notch Signaling, 93–104. Singapore: Springer Singapore, 2017. http://dx.doi.org/10.1007/978-981-10-4971-2_6.
Full textConference papers on the topic "Notch"
Ucar-Bilyeu, Deniz A., Margarite D. MATOSSIAN, VAN Hoang Barnes, Fokhrul M. Hossain, Mohit Gupta, HOPE E. BURKS, THOMAS D. WRIGHT, et al. "Abstract 967: Targeting notch one notch above." In Proceedings: AACR Annual Meeting 2018; April 14-18, 2018; Chicago, IL. American Association for Cancer Research, 2018. http://dx.doi.org/10.1158/1538-7445.am2018-967.
Full textHendrix, Karen D., Charles A. Hulse, Georg J. Ockenfuss, and Robert B. Sargent. "Demonstration of narrowband notch and multi-notch filters." In Optical Engineering + Applications, edited by Jennifer D. T. Kruschwitz and Michael J. Ellison. SPIE, 2008. http://dx.doi.org/10.1117/12.795498.
Full textHartmann, C. S., J. C. Andle, and M. B. King. "SAW Notch Filters." In IEEE 1987 Ultrasonics Symposium. IEEE, 1987. http://dx.doi.org/10.1109/ultsym.1987.198941.
Full textOwen, Harry. "Holographic notch filter." In San Diego, '91, San Diego, CA, edited by Ivan Cindrich and Sing H. Lee. SPIE, 1991. http://dx.doi.org/10.1117/12.50638.
Full textPanja, Ardhendu, Arnab Bhattacharya, and Tribeni Prasad Banerjee. "Design and Analysis of Notch Depth for T-Notch Filter." In 2020 National Conference on Emerging Trends on Sustainable Technology and Engineering Applications (NCETSTEA). IEEE, 2020. http://dx.doi.org/10.1109/ncetstea48365.2020.9119943.
Full textPathak, Vikas, Satyasai Jagannath Nanda, Amit Mahesh Joshi, and Sitanshu Sekhar Sahu. "High Speed Implementation of Notch/Anti-notch IIR Filter on FPGA." In 2018 15th IEEE India Council International Conference (INDICON). IEEE, 2018. http://dx.doi.org/10.1109/indicon45594.2018.8986985.
Full textKwok, Kam-cheung, and Ming-kam Chan. "Parallel DC notch filter." In San Diego, '91, San Diego, CA, edited by Andrew G. Tescher. SPIE, 1991. http://dx.doi.org/10.1117/12.50859.
Full textNing, Alex, and Jon D. Masso. "Multiline holographic notch filters." In San Diego, '91, San Diego, CA, edited by Jeremy M. Lerner and Wayne R. McKinney. SPIE, 1991. http://dx.doi.org/10.1117/12.49408.
Full textWachirarattanapornkul, Sorapong. "Active DURC notch filter." In 2014 4th Joint International Conference on Information and Communication Technology, Electronic and Electrical Engineering (JICTEE). IEEE, 2014. http://dx.doi.org/10.1109/jictee.2014.6804122.
Full textHryniewicz, J. V., P. P. Absil, B. E. Little, R. A. Wilson, L. G. Joneckis, and P. T. Ho. "Microring resonator notch filters." In Conference on Lasers and Electro-Optics (CLEO 2000). Technical Digest. Postconference Edition. TOPS Vol.39. IEEE, 2000. http://dx.doi.org/10.1109/cleo.2000.907438.
Full textReports on the topic "Notch"
Huang, Yuchen. Adaptive Notch Filter. Portland State University Library, January 2000. http://dx.doi.org/10.15760/etd.6686.
Full textMehta, Samir, and Kurt Hankenson. Notch Signaling in Bone Regeneration. Fort Belvoir, VA: Defense Technical Information Center, October 2011. http://dx.doi.org/10.21236/ada564010.
Full textLee, Eun U., Bruce A. Pregger, Robert E. Taylor, and Charles Lei. Biaxial Fatigue Cracking from Notch. Fort Belvoir, VA: Defense Technical Information Center, March 2013. http://dx.doi.org/10.21236/ada575515.
Full textMohn, Gillian. Top Notch Stitching documentation redesign. Ames (Iowa): Iowa State University, December 2021. http://dx.doi.org/10.31274/cc-20240624-1509.
Full textKim, Minji. Notch in Pathological Angiogenesis and Lymphangiogenesis. Fort Belvoir, VA: Defense Technical Information Center, May 2013. http://dx.doi.org/10.21236/ada581029.
Full textKim, Minji. Notch in Pathological Angiogenesis and Lymphangiogenesis. Fort Belvoir, VA: Defense Technical Information Center, May 2012. http://dx.doi.org/10.21236/ada589440.
Full textKim, Minji. Notch in Pathological Angiogenesis and Lymphangiogenesis. Fort Belvoir, VA: Defense Technical Information Center, May 2011. http://dx.doi.org/10.21236/ada550314.
Full textJeffries, Shawn. Molecular Mechanisms of Notch Signaling in Neoplasia. Fort Belvoir, VA: Defense Technical Information Center, August 2002. http://dx.doi.org/10.21236/ada411237.
Full textMaxey and Barnes. L51622 The Chevron Notched Drop-Weight-Tear-Test Specimen. Chantilly, Virginia: Pipeline Research Council International, Inc. (PRCI), September 1990. http://dx.doi.org/10.55274/r0010366.
Full textMcGinnis, Dave, and /Fermilab. Phase Advance for Wideband Dampers With Notch Filters. Office of Scientific and Technical Information (OSTI), February 2000. http://dx.doi.org/10.2172/984605.
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