Academic literature on the topic 'Normal-tissues toxicity'
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Journal articles on the topic "Normal-tissues toxicity"
Mortezaee, Keywan, Masoud Najafi, Bagher Farhood, Amirhossein Ahmadi, Dheyauldeen Shabeeb, and Ahmed E. Musa. "NF‐κB targeting for overcoming tumor resistance and normal tissues toxicity." Journal of Cellular Physiology 234, no. 10 (March 25, 2019): 17187–204. http://dx.doi.org/10.1002/jcp.28504.
Full textMortezaee, Keywan, Masoud Najafi, Bagher Farhood, Amirhossein Ahmadi, Dheyauldeen Shabeeb, and Ahmed E. Musa. "Resveratrol as an Adjuvant for Normal Tissues Protection and Tumor Sensitization." Current Cancer Drug Targets 20, no. 2 (February 11, 2020): 130–45. http://dx.doi.org/10.2174/1568009619666191019143539.
Full textNajafi, Masoud, Elahe Motevaseli, Alireza Shirazi, Ghazale Geraily, Abolhasan Rezaeyan, Farzad Norouzi, Saeed Rezapoor, and Hamid Abdollahi. "Mechanisms of inflammatory responses to radiation and normal tissues toxicity: clinical implications." International Journal of Radiation Biology 94, no. 4 (March 7, 2018): 335–56. http://dx.doi.org/10.1080/09553002.2018.1440092.
Full textPicut, Catherine A., and George A. Parker. "Postnatal Organ Development as a Complicating Factor in Juvenile Toxicity Studies in Rats." Toxicologic Pathology 45, no. 1 (October 17, 2016): 248–52. http://dx.doi.org/10.1177/0192623316671609.
Full textLee, F. Y., and P. Workman. "Misonidazole protects mouse tumour and normal tissues from the toxicity of oral CCNU." British Journal of Cancer 51, no. 1 (January 1985): 85–91. http://dx.doi.org/10.1038/bjc.1985.12.
Full textLinard, Christine, and Maâmar Souidi. "PPARs in Irradiation-Induced Gastrointestinal Toxicity." PPAR Research 2010 (2010): 1–12. http://dx.doi.org/10.1155/2010/528327.
Full text&NA;. "Amifostine protects a broad range of normal tissues from chemotherapy- and radiotherapy-associated toxicity." Drugs & Therapy Perspectives 17, no. 21 (October 2001): 1–5. http://dx.doi.org/10.2165/00042310-200117210-00001.
Full textTaylor, C. W., L. M. Wang, A. F. List, D. Fernandes, G. D. Paine-Murrieta, C. S. Johnson, and R. L. Capizzi. "Amifostine protects normal tissues from paclitaxel toxicity while cytotoxicity against tumour cells is maintained." European Journal of Cancer 33, no. 10 (September 1997): 1693–98. http://dx.doi.org/10.1016/s0959-8049(97)00221-9.
Full textChen, Nan, Yuping Han, Yao Luo, Yanfeng Zhou, Xingjie Hu, Yun Yu, Xiaodong Xie, et al. "Nanodiamond-based non-canonical autophagy inhibitor synergistically induces cell death in oxygen-deprived tumors." Materials Horizons 5, no. 6 (2018): 1204–10. http://dx.doi.org/10.1039/c8mh00993g.
Full textKe, Yong, Keqiang Ye, Hans E. Grossniklaus, David R. Archer, Harish C. Joshi, and Judith A. Kapp. "Noscapine inhibits tumor growth with little toxicity to normal tissues or inhibition of immune responses." Cancer Immunology, Immunotherapy 49, no. 4-5 (June 19, 2000): 217–25. http://dx.doi.org/10.1007/s002620000109.
Full textDissertations / Theses on the topic "Normal-tissues toxicity"
MANGONI, MONICA. "PHARMACOLOGICAL MODULATION OF NORMAL TISSUES RESPONSETO RADIATION-INDUCED DAMAGES." Doctoral thesis, 2009. http://hdl.handle.net/2158/599071.
Full textIngram, N., L. E. McVeigh, R. H. Abou-Saleh, J. Maynard, S. A. Peyman, J. R. McLaughlan, M. Fairclough, et al. "Ultrasound-triggered therapeutic microbubbles enhance the efficacy of cytotoxic drugs by increasing circulation and tumour drug accumulation and limiting bioavailability and toxicity in normal tissues." 2020. http://hdl.handle.net/10454/17999.
Full textMost cancer patients receive chemotherapy at some stage of their treatment which makes improving the efficacy of cytotoxic drugs an ongoing and important goal. Despite large numbers of potent anti-cancer agents being developed, a major obstacle to clinical translation remains the inability to deliver therapeutic doses to a tumor without causing intolerable side effects. To address this problem, there has been intense interest in nanoformulations and targeted delivery to improve cancer outcomes. The aim of this work was to demonstrate how vascular endothelial growth factor receptor 2 (VEGFR2)-targeted, ultrasound-triggered delivery with therapeutic microbubbles (thMBs) could improve the therapeutic range of cytotoxic drugs. Methods: Using a microfluidic microbubble production platform, we generated thMBs comprising VEGFR2-targeted microbubbles with attached liposomal payloads for localised ultrasound-triggered delivery of irinotecan and SN38 in mouse models of colorectal cancer. Intravenous injection into tumor-bearing mice was used to examine targeting efficiency and tumor pharmacodynamics. High-frequency ultrasound and bioluminescent imaging were used to visualise microbubbles in real-time. Tandem mass spectrometry (LC-MS/MS) was used to quantitate intratumoral drug delivery and tissue biodistribution. Finally, 89Zr PET radiotracing was used to compare biodistribution and tumor accumulation of ultrasound-triggered SN38 thMBs with VEGFR2 targeted SN38 liposomes alone. Results: ThMBs specifically bound VEGFR2 in vitro and significantly improved tumor responses to low dose irinotecan and SN38 in human colorectal cancer xenografts. An ultrasound trigger was essential to achieve the selective effects of thMBs as without it, thMBs failed to extend intratumoral drug delivery or demonstrate enhanced tumor responses. Sensitive LC-MS/MS quantification of drugs and their metabolites demonstrated that thMBs extended drug exposure in tumors but limited exposure in healthy tissues, not exposed to ultrasound, by persistent encapsulation of drug prior to elimination. 89Zr PET radiotracing showed that the percentage injected dose in tumors achieved with thMBs was twice that of VEGFR2-targeted SN38 liposomes alone. Conclusions: thMBs provide a generic platform for the targeted, ultrasound-triggered delivery of cytotoxic drugs by enhancing tumor responses to low dose drug delivery via combined effects on circulation, tumor drug accumulation and exposure and altered metabolism in normal tissues.
EPSRC funding (EP/I000623/1, EP/K023845/1 and EP/P023266/1) and the MRC for a Confidence in Concept award and MR/L01629X. L.E. McVeigh was funded by an EPSRC PhD Studentship (EP/L504993/1).
Book chapters on the topic "Normal-tissues toxicity"
"High dose therapy (autologus transplant)." In Oxford Handbook of Cancer Nursing, edited by Mike Tadman and Dave Roberts, 261–68. Oxford University Press, 2007. http://dx.doi.org/10.1093/med/9780198569244.003.0020.
Full textBalzano, Tiziano, and Omar El Hiba. "Metal Toxicity and Brain-Liver Axis." In Advances in Environmental Engineering and Green Technologies, 216–35. IGI Global, 2019. http://dx.doi.org/10.4018/978-1-5225-7775-1.ch011.
Full textSweeney, Connor, Lynn Quek, Betty Gration, and Paresh Vyas. "Cancer stem cells." In Oxford Textbook of Cancer Biology, edited by Francesco Pezzella, Mahvash Tavassoli, and David J. Kerr, 283–300. Oxford University Press, 2019. http://dx.doi.org/10.1093/med/9780198779452.003.0020.
Full textJanapati, Yasodha Krishna, Sunil Junapudi, and Sudharshan Reddy Dachani. "Overview of Nano-Strategies for Combating Cancer." In Handbook of Research on Nano-Strategies for Combatting Antimicrobial Resistance and Cancer, 250–70. IGI Global, 2021. http://dx.doi.org/10.4018/978-1-7998-5049-6.ch012.
Full textSaltzman, W. Mark. "Objecives of Tissue Engineering." In Tissue Engineering. Oxford University Press, 2004. http://dx.doi.org/10.1093/oso/9780195141306.003.0006.
Full textSprings, Clark L. "Corneal Complications." In Complications of Glaucoma Surgery. Oxford University Press, 2013. http://dx.doi.org/10.1093/oso/9780195382365.003.0042.
Full textConference papers on the topic "Normal-tissues toxicity"
Ambati, Srikanth R., Shieh JaeHung, Benet Pera, Elissa W. P. Wong, Eloisi Caldas Lopes, Elizabeth Peguero, Tsann-Long Su, and Malcolm A. S. Moore. "Abstract 1625: Ureidomustine, a novel DNA-crosslinking agent shows activity in sarcoma preclinical models and lacks toxicity in normal tissues." In Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.am2015-1625.
Full textCogdill, Alexandria P., Alina Boesteanu, Kathleen Haines, Joseph Fraietta, John Scholler, Andreas Loew, Pramod Thekkat, et al. "Abstract B05: A biologic screen to evaluate potential toxicity of chimeric antigen receptor modified T cells against primary normal human tissues." In Abstracts: AACR Special Conference: Tumor Immunology and Immunotherapy: A New Chapter; December 1-4, 2014; Orlando, FL. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/2326-6074.tumimm14-b05.
Full textSchoor, Oliver, Jens Fritsche, Sarah Kutscher, Andrea Mahr, Lea Stevermann, Annika Sonntag, Franziska Hoffgaard, et al. "Abstract 2291: On- and off target toxicity profiling for adoptive cell therapy by mass spectrometry-based immunopeptidome analysis of primary human normal tissues." In Proceedings: AACR 107th Annual Meeting 2016; April 16-20, 2016; New Orleans, LA. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1538-7445.am2016-2291.
Full textBenammar, Sarra, Fatima Mraiche, Jensa Mariam Joseph, and Katerina Gorachinova. "Glucose and Transferrin Liganded PLGA Nanoparticles Internalization in Non-Small Lung Cancer Cells." In Qatar University Annual Research Forum & Exhibition. Qatar University Press, 2020. http://dx.doi.org/10.29117/quarfe.2020.0227.
Full textReports on the topic "Normal-tissues toxicity"
Morrow, Charles S. Turning Chemopreventive Agents Against Breast Cancer: Sensitizing Cancers to Therapeutics While Protecting Normal Tissues from Toxicity. Fort Belvoir, VA: Defense Technical Information Center, July 2012. http://dx.doi.org/10.21236/ada589289.
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