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1

Normal-pressure hydrocephalus: Pathology, pathophysiology, diagnostics, therapeutics and clinical course. Ratingen: PVV Science Publications, 2003.

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2

Young, Harold, and Anthony Marmarou. The estimated incidence of normal pressure hydrocephalus in assisted living and extended care facilities for the senior Virginia residents: Report of the Division of Neurological Surgery at the Medical College of Virginia of Virginia Commonwealth University to the Governor and the General Assembly of Virginia. Richmond, Va: Commonwealth of Virginia, 2005.

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3

Meier, Ullrich, Michael J. Fritsch, and Uwe Kehler. Normal Pressure Hydrocephalus: Pathophysiology, Diagnosis, Treatment. Thieme Medical Publishers, Incorporated, 2013.

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4

Mednick, Adam S. Normal Pressure Hydrocephalus: From Diagnosis to Treatment. Addicus Books, 2013.

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5

Mednick, Adam S. Normal Pressure Hydrocephalus: From Diagnosis to Treatment. Addicus Books, 2013.

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6

Adam S. Mednick MD PhD. Normal Pressure Hydrocephalus: From Diagnosis to Treatment. Addicus Books, 2013.

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7

Beller, Jerry, and Beller Health. 2019 Normal Pressure Hydrocephalus: This Dementia Strikes All Ages! Independently Published, 2019.

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8

Briggs, John, Jerry Beller, Beller Health, and Brain Research. Normal Pressure Hydrocephalus: Guide for Doctors, Nurses, Patients, Families, and Caregivers. Independently Published, 2020.

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9

Whittle, Ian. Raised intracranial pressure, cerebral oedema, and hydrocephalus. Oxford University Press, 2011. http://dx.doi.org/10.1093/med/9780198569381.003.0604.

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The brain is protected by the cranial skeleton. Within the intracranial compartment are also cerebrospinal fluid, CSF, and the blood contained within the brain vessels. These intracranial components are in dynamic equilibrium due to the pulsations of the heart and the respiratory regulated return of venous blood from the brain. Normally the mean arterial blood pressure, systemic venous pressure, and brain volume are regulated to maintain physiological values for intracranial pressure, ICP. There are a range of very common disorders such as stroke, and much less common, such as idiopathic intracranial hypertension, that are associated with major disturbances of intracranial pressure dynamics. In some of these the contribution to pathophysiology is relatively minor whereas in others it may be substantial and be a major contributory factor to morbidity or even death.Intracranial pressure can be disordered because of brain oedema, disturbances in CSF flow, mass lesions, and vascular engorgement of the brain. Each of these may have variable causes and there may be interactions between mechanisms. In this chapter the normal regulation of intracranial pressure is outlined and some common disease states in clinical neurological practice that are characterized by either primary or secondary problems in intracranial pressure dynamics described.
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10

Institute, Brain, John Briggs, and Beller Health. Neglected DEMENTIAS: Normal Pressure Hydrocephalus, Huntington's Disease, Korsakoff Syndrome, Creutzfeldt-Jakob Disease, & Amyotrophic Lateral Sclerosis. Independently Published, 2020.

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11

Beller, Jerry, and Beller Health. Dementia Types, Risk Factors, and Symptoms: Alzheimer's Disease Vascular Lewy Body Frontotemporal Huntington's Normal Pressure Hydrocephalus Wernicke Korsakoff Dementias. Independently Published, 2019.

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12

Beller, Jerry, and Beller Health. Dementia Types, Risk Factors, and Symptoms 2019: Alzheimer's Disease , Vascular , Lewy Body , Frontotemporal , Huntington's , Normal Pressure Hydrocephalus , Wernicke Korsakoff Dementias. Independently Published, 2019.

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13

Misulis, Karl E., and E. Lee Murray. CSF Circulation Disorders. Edited by Karl E. Misulis and E. Lee Murray. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190259419.003.0026.

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The most common CSF circulation disorders encountered in hospital neurology practice are high CSF pressure, low CSF pressure, and suspected normal pressure hydrocephalus (NPH). This chapter discusses the presentation, diagnosis, and management of a number of the most common CSF circulation disorders.
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14

Kaplan, Tamara, and Tracey Milligan. Dementia 2: CJD, NPH, and Summary (DRAFT). Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190650261.003.0010.

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The video in this chapter explores dementia, and focuses on Creutzfeldt Jakob Disease (CJD), and Normal Pressure Hydrocephalus (NPH). It outlines the causes and symptoms of CJD, as well as diagnostic tests (MRI, CSF presence of protein 14-3-3, EEG, and biopsy). It also discusses NPH, including its characteristics and treatment.
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15

Fox, Susan H. Falls. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780190607555.003.0014.

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Frontal lobe gait disorders are characterized by a pattern of gait that is not explained by extrapyramidal or pyramidal dysfunction with dyspraxic features reflecting a “higher order” difficulty with the coding of the pattern of movement required for normal gait rather than the subcortical control of gait or the pyramidal final common pathway. Magnetic resonance imaging is the most useful single investigation that tends to reveal vascular or neurodegenerative etiologies, with the less common normal pressure hydrocephalus being the one treatable cause that should not be missed. The majority of higher order frontal lobe gait disorders are not treatable and patients require a wheelchair for safety.
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16

Graham, Andrew. Neurological dementias. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199644957.003.0037.

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Dementia in old age is usually due to Alzheimer’s disease, cerebrovascular disease, or mixed pathology. Dementia due to other neurological disorders is uncommon, but important to recognise because management may be very different to that in primary or vascular dementia. This chapter surveys five neurological conditions that may present with dementia in later life: idiopathic normal pressure hydrocephalus (INPH); Huntington’s disease (HD); multiple sclerosis (MS); autoimmune limbic encephalitis (LE); and prion disease. For each disorder the epidemiology, clinical features, investigations & treatment are reviewed, with examples of the characteristic brain imaging changes. Accurate diagnosis of these conditions can be challenging even for physicians with a special interest in dementia, and often requires a neurological referral.
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17

Bowker, Lesley K., James D. Price, Ku Shah, and Sarah C. Smith. Psychiatry. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198738381.003.0009.

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This chapter provides information on cognitive ageing, impairments in cognitive function without dementia, overview of dementia, assessment of dementia, dementia and common diseases, dementia and parkinsonism, normal pressure hydrocephalus, dementia and less common diseases, general management of dementia, risk management and abuse in dementia, prevention of dementia, use of acetylcholinesterase inhibitors in dementia, other drug treatments for dementia, managing behavioural problems in dementia, compulsory detention and treatment, psychosis, diagnosis of delirium, causes of delirium, clinical assessment of delirium, treatment issues in delirium, non-drug management of delirium, drug treatments for delirium, confusion and alcohol, squalor syndrome, presentation of depression, clinical features of depression, non-drug management of depression, drug treatments for depression, and suicide and attempted suicide.
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18

Mason, Peggy. Following the Nutrients. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190237493.003.0008.

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Consciousness depends on oxygen delivered to the brain by arterial blood. Compromises to this delivery by an increase in intracranial pressure or decrease in available oxygen can produce syncope. The blood supply to the forebrain stems from the internal carotids that serve the anterior circulation. The posterior circulation is fed by the vertebral arteries and supplies blood to the brainstem. Redundancy to the brain’s blood supply is served by anastomoses, a connection between the posterior and anterior circulations, and by the Circle of Willis. The clinical characteristics of common brainstem and cerebral strokes are described. Similarly, the characteristics and clinical prognosis of different types of intracranial bleeds are explained. The text covers mechanisms that normally protect the brain and the consequences of traumatic brain injury that overwhelms these protections. A description of the production and circulation of cerebrospinal fluid allows the student to understand hydrocephalus.
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