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1
Vutha, Amit C. "Normal Forms and Unfoldings of Singular Strategy Functions." The Ohio State University, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=osu1385461288.
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Schnell, Christian. "The boundary behavior of cohomology classes and singularities of normal functions." Columbus, Ohio : Ohio State University, 2008. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1218036000.
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Colwell, Jason Andrew. "Normal functions and their application to the Hodge Conjecture." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp05/mq22588.pdf.
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Mainville, Andre. "The altimetry-gravimetry problem using orthonormal base functions /." The Ohio State University, 1987. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487325740718359.
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Gologlu, Faruk. "Divisibility Properties On Boolean Functions Using The Numerical Normal Form." Master's thesis, METU, 2004. http://etd.lib.metu.edu.tr/upload/2/12605549/index.pdf.
Full textAbstract:
A Boolean function can be represented in several different forms. These different
representation have advantages and disadvantages of their own. The Algebraic Normal
Form, truth table, and Walsh spectrum representations are widely studied in
literature. In 1999, Claude Carlet and Phillippe Guillot introduced the Numerical
Normal Form. NumericalNormal Form(NNF) of a Boolean function is similar to Algebraic
Normal Form, with integer coefficients instead of coefficients from the two
element field. Using NNF representation, just like the Walsh spectrum, characterization
of several cryptographically important functions, such as resilient and bent
functions, is possible. In 2002, Carlet had shown several divisibility results concerning
resilient and correlation-immune functions using NNF. With these divisibility
results, Carlet is able to give bounds concerning nonlinearity of resilient and correlation
immune functions.
In this thesis, following Carlet and Guillot, we introduce the Numerical Normal
Form and derive the pairwise relations between the mentioned representations.
Characterization of Boolean, resilient and bent functions using NNF is also given.
We then review the divisibility results of Carlet, which will be linked to some results
on the nonlinearity of resilient and correlation immune functions.
We show the Möbius inversion properties of NNF of a Boolean function, using Gian-Carlo Rota&rsquo
s work as a guide. Finally, using a lot of the mentioned results, we prove a necessary condition on theWalsh spectrum of Boolean functions with given degree.
6
Sulak, Fatih. "Constructions Of Bent Functions." Master's thesis, METU, 2006. http://etd.lib.metu.edu.tr/upload/12607035/index.pdf.
Full textAbstract:
In cryptography especially in block cipher design, Boolean functions are the
basic elements. A cryptographic function should have high nonlinearity as it can
be attacked by linear attack.
In this thesis the highest possible nonlinear boolean functions in the even
dimension, that is bent functions, basic properties and construction methods of
bent functions are studied. Also normal bent functions and generalized bent
functions are presented.
7
Verthelyi, Daniela I. "Effects of estrogen on the B cell functions of normal mice." Diss., This resource online, 1996. http://scholar.lib.vt.edu/theses/available/etd-08062007-094416/.
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Calik, Cagdas. "Computing Cryptographic Properties Of Boolean Functions From The Algebraic Normal Form Representation." Phd thesis, METU, 2013. http://etd.lib.metu.edu.tr/upload/12615759/index.pdf.
Full textAbstract:
Boolean functions play an important role in the design and analysis of symmetric-key cryptosystems,
as well as having applications in other fields such as coding theory. Boolean functions
acting on large number of inputs introduces the problem of computing the cryptographic
properties. Traditional methods of computing these properties involve transformations which
require computation and memory resources exponential in the number of input variables. When
the number of inputs is large, Boolean functions are usually defined by the algebraic normal
form (ANF) representation. In this thesis, methods for computing the weight and nonlinearity
of Boolean functions from the ANF representation are investigated. The relation between the
ANF coecients and the weight of a Boolean function was introduced by Carlet and Guillot.
This expression allows the weight to be computed in $mathcal{O}(2^p)$ operations for a Boolean function
containing p monomials in its ANF. In this work, a more ecient algorithm for computing the
weight is proposed, which eliminates the unnecessary calculations in the weight expression. By
generalizing the weight expression, a formulation of the distances to the set of linear functions
is obtained. Using this formulation, the problem of computing the nonlinearity of a Boolean
function from its ANF is reduced to an associated binary integer programming problem. This
approach allows the computation of nonlinearity for Boolean functions with high number of
input variables and consisting of small number of monomials in a reasonable time.
9
Zhou, Yuwen, and 周彧雯. "Magnetic resonance imaging investigation of normal and altered brain functions and metabolisms." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hub.hku.hk/bib/B48329691.
Full textAbstract:
Benefiting from higher SNR as well as better spatial, temporal and spectral resolution, magnetic resonance imaging (MRI) at high field has proved to be a valuable neuroimaging modality which provides comprehensive evaluation of the central nervous system non-invasively. The objectives of this doctoral work were to develop MRI methodologies and to assess the functional, metabolic and structural alterations in rodent brains under normal and manipulated conditions.
Firstly, to improve the functional sensitivity and spatial precision, a novel functional MRI (fMRI) method using balanced steady state free precession with intravascular susceptibility contrast agent was proposed and its feasibility was evaluated in rat visual system. This new approach was sensitized to cerebral blood volume (CBV) changes. It provided comparable sensitivity to conventional CBVweighted fMRI using echo planar imaging but with no severe image distortion and signal dropout. Robust negative responses during visual stimulation were observed and activation patterns were in excellent agreement with known neuroanatomy. As a promising alternative to conventional CBV-weighted fMRI, it was particularly suited for fMRI investigation of animal models at high field.
Secondly, the relationship between anatomical connections and resting-state fMRI connectivity was explored using a well-controlled animal model of corpus callosotomy. Both complete and partial callosotomy resulted in significant loss of interhemispheric connectivity in the cortical areas whose primary interhemispheric connections via corpus callosum (CC) were severed. Partial restoration of interhemispheric connectivity and increased intrahemispheric connectivity were also observed. The experimental findings directly supported that anatomical connections via CC play a primary and indispensable role in resting-state connectivity, and that resting-state networks could be dynamically reorganized or acquired directly or indirectly through the remaining anatomical connections.
Thirdly, proton magnetic resonance spectroscopy (1H MRS) was employed to monitor the longitudinal metabolic alterations elicited by exogenous stimulation and endogenous modification, respectively. Significantly lower hippocampal N-acetylaspartate (NAA) was observed in fear conditioning animals, indicating reduced neuronal dysfunction and/or integrity, which contributed to the trauma-related symptoms. Meanwhile, pregnant animals exhibited prominently higher hippocampal NAA level, reflecting the increased density of neurons in this region, which might facilitate supporting behaviors that involving learning and memory. The 1H MRS detection of ongoing neurochemical changes induced by fear conditioning and pregnancy, especially in the hippocampus, can shed light on the mechanisms of learning and memory and the neurochemical underpinnings of behavioral improvement in pregnant animals.
Lastly, manganese-enhanced MRI (MEMRI) was employed to investigate the hypoxic-ischemic (HI) injury in the late phase and the neural response to conditioned fear. Significantly higher enhancement in T1-weighted images was found in the peri-lesional region 24 hours after manganese administration and it colocalized with the increase in glial cell density in histological staining, demonstrating the existence of reactive gliosis in the late phase after HI injury. In fear conditioned animals, higher manganese uptake was observed in amygdala, hippocampus, paraventricular nucleus of hypothalamus and cingulate cortex, which were all highly-involved in the process of fear. These findings suggested MEMRI approach were useful in investigation of post-injury cellular events and functional reorganization as well as for in vivo mapping of neuronal activity.published_or_final_version
Electrical and Electronic Engineering
Doctoral
Doctor of Philosophy
10
Ngailo, Edward. "On functions of a Wishart matrix and a normal vector with applications." Licentiate thesis, Stockholms universitet, Matematiska institutionen, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-154403.
Full textAbstract:
This thesis consists of two papers which take a critical look on functions of an inverse Wishart matrix and a Gaussian vector. In the first paper, the product expression, of which the inverse of the pooled estimator of the covariance matrix is inverse Wishart distributed and the difference of sample means is multivariate normally distributed, is investigated by exploring the distributional properties via a stochastic representation for both the finite sample case and the infinite sample case under the large-dimensional asymptotic regime. A test theory is developed to study the contribution of population coefficients in the discriminant function. Furthermore, we investigate the performance of the classification analysis based on the discriminant function. In the second paper, the expression of the product of the inverse sample covariance matrix and the sample mean vector with regard to the derivation of moments of the estimated tangency portfolio weights is studied. In particular, higher order central and non-central moments of the elements of such a product are obtained. Moreover, the closed-form expressions of the second, the third and the fourth central moments are provided whose expressions do not depend on special mathematical functions, like the confluent hypergeometric function. Furthermore, we deduce analytical expressions for the mean, the variance, the skewness, and the kurtosis from the higher-order central and non-central moments of the tangency portfolio weights. Finally, the developed results have been successfully applied to real weekly data of eight stocks traded on NASDAQ.
11
Bozorgmehr, Tahereh. "Behavioural investigation of normal and mutant human presenilin functions in caenorhabditis elegans." Thesis, University of British Columbia, 2015. http://hdl.handle.net/2429/54803.
Full textAbstract:
Presenilins are well known as sites of mutations responsible for early-onset Alzheimer's disease. The normal functions of presenilins and the mechanisms by which presenilins cause Alzheimer disease are not yet known. Conservation of cellular and molecular functions between the C.elegans and human genes makes it a powerful experimental model organism to investigate cellular mechanisms of Alzheimer's disease and neurodegenerative disorders in general. Mutations in the C.elegans presenilin1homologue, sel-12, decrease Notch signaling activity, which results in an egg-laying deficit in these animals. It has been well established that pathogenic PS1 mutations impair Notch signaling; however, in the first part of this thesis we showed that a recently discovered PS1Δs₁₆₉ human mutation rescued the egg-laying deficit associated with Lin12/Notch pathway, suggesting that in this pathogenic PS1 mutation Notch processing remained intact.
In the second part of this thesis the behavioural phenotypes of a mutation in the C.elegans presenilin homologue, sel-12, were studied. Our results revealed that a mutation in the sel-12 gene causes chemotaxis deficits toward volatile and water-soluble stimuli in sel-12 mutant animals. Reintroducing the sel-12 or the wild-type human presenilin gene decreased those behavioural phenotypes, indicating that the observed chemotaxis deficits were dependent on sel-12 activity. However, rescuing with the human PS1C₄₁₀Y mutation, which has a severe effect on Notch processing, did not ameliorate the chemotaxis deficit; in contrast, rescuing with PS1Δs₁₆₉ rescued both volatile and water-soluble chemotaxis impairments suggesting that the chemotaxis deficit causing by sel-12 mutation depends on the Notch pathway.Medicine, Faculty of
Graduate
12
Smart, Jane. "Psychometric functions of clear and conversational speech for young normal hearing listeners in noise." [Tampa, Fla.] : University of South Florida, 2007. http://purl.fcla.edu/usf/dc/et/SFE0002137.
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Hallows, Janice Lynn. "Developmental expression and functions of voltage-gated potassium channels in normal and mutant mice /." Thesis, Connect to this title online; UW restricted, 1999. http://hdl.handle.net/1773/6291.
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Salamanca, Melissa, and Melissa Salamanca. "Beta₃-adrenergic receptors in the heart: Normal functions and potential roles in heart failure." Thesis, The University of Arizona, 2016. http://hdl.handle.net/10150/621455.
Full textAbstract:
Heart Failure is the state in which the heart is unable to pump enough blood to meet the needs of the body, resulting from events that progressively damage the myocardium and/or its ability to contract normally. Several compensatory mechanisms allow for short-term maintenance of adequate delivery of blood to the body. Progression from the initial events to heart failure is caused by the accumulation of pathologic changes and their effects, many of which result from chronic activation of these compensatory mechanisms. One of these mechanisms is the activation of the neurohormonal β-adrenergic system, to which the β₃-adrenergic receptor (β₃-AR) belongs. Research on the role of the β₃-AR in the heart has focused on the short-term protective role of the receptor, based on its ability to reduce the effects of over-stimulation of the heart's other adrenergic-system components. However, during the course of heart failure, its up-regulation and functional persistence may also contribute to the progression of the disease. There have been few large-animal studies, no human trials, and no long-term studies of β₃-AR agonists for use in the treatment of heart failure. Ultimately, individualized treatment strategies that, over time, modulate the relative levels of agonistic and antagonistic effects across each of the three β₃-AR subtypes, may be most effective for management of heart failure. However, further research and trials with β₃-AR agonists are realistic and necessary places to start.
15
Mitsis, Effie M. "Construct validity of executive functions in normal adults and in adults with mild cognitive impairment." Full text available, 2003. http://images.lib.monash.edu.au/ts/theses/mitsis.pdf.
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LeBlanc, Kimberly T. "Runx Expression in Normal and Osteoarthritic Cartilage: Possible Functions of Runx Proteins in Chondrocytes: A Dissertation." eScholarship@UMMS, 2002. http://escholarship.umassmed.edu/gsbs_diss/655.
Full textAbstract:
The Runx family of transcription factors supports cell fate determination, cell cycle regulation, global protein synthesis control, and genetic as well as epigenetic regulation of target genes. Runx1, which is essential for hematopoiesis; Runx2, which is required for osteoblast differentiation; and Runx3, which is involved in neurologic and gut development; are expressed in the growth plate during chondrocyte maturation, and in the chondrocytes of permanent cartilage structures. While Runx2 is known to control genes that contribute to chondrocyte hypertrophy, the functions of Runx1 and Runx3 during chondrogenesis and in cartilage tissue have been less well studied.
The goals of this project were to characterize expression of Runx proteins in articular cartilage and differentiating chondrocytes and to determine the contribution of Runx1 to osteoarthritis (OA). Here, the expression pattern of Runx1 and Runx2 was characterized in normal bovine articular cartilage. Runx2 is expressed at higher levels in deep zone chondrocytes, while Runx1 is primarily expressed in superficial zone chondrocytes, which is the single cell layer that lines the surface of articular cartilage. Based on this finding, the hypothesis was tested that Runx1 is involved in osteoarthritis, which is a disease characterized by degradation of articular cartilage and changes in chondrocytes. These studies showed that Runx1 is upregulated in articular cartilage explants in response to mechanical compression. Runx1 was also expressed in chondrocytes found at the periphery of OA lesions in the articular cartilage of mice that underwent an OA-inducing surgery. Runx1 was also upregulated in cartilage explants of human osteoarthritic knees, and IHC data showed that Runx1 is mainly expressed in chondrocyte “clones” characteristic of OA.
To ascertain the potential function of the upregulation of Runx1 in these cartilage stress conditions and disease states, the hypothesis was tested that Runx1 is upregulated in very specific chondrocyte populations in response to the cartilage damage in osteoarthritis. These studies addressed the properties of these cells that related to functions in cell growth and differentiation. In both the surface layer of normal articular cartilage, and in OA cartilage, Runx1 expression by IF co-localized with markers of mesenchymal progenitor cells, as well as markers of proliferation Ki-67 and PCNA. This finding indicated that Runx1 is found in a population of cells that represent a proliferative population of mesenchymal progenitor cells in osteoarthritis.
To further address Runx1 function and identify downstream targets of Runx proteins, a promoter analysis of genes that are known to be either downregulated or upregulated during chondrocyte maturation was done. These studies found that many of these genes have 1 or more Runx binding sites within 2kb of their transcription start site, indicating that they are potential downstream Runx target genes.
Lastly, some preliminary experiments were done to characterize novel roles of Runx proteins in the chondrocyte. Runx proteins have been shown to epigenetically regulate their target genes by remaining bound to them throughout mitosis, “poising” them for transcription upon exit from mitosis. The hypothesis that Runx proteins also function by remaining bound to their target genes throughout mitosis in chondrocytes was tested. It was demonstrated by immunofluorescense imaging of Runx proteins on metaphase chromosomes of ATDC5 cells, that Runx2 remains bound to chromosomes during mitosis.
Cell proliferation and hypertrophy are both linked to increases in protein synthesis. Runx factors, which regulate rates of global protein synthesis, are expressed in both proliferating and hypertrophic chondrocytes. Thus, it was hypothesized that Runx proteins regulate rates of global protein synthesis during chondrocyte maturation. These studies showed that the overexpression of Runx proteins in a chondrocyte cell line (ATDC5) did not affect protein synthesis rates or levels of protein synthesis machinery. Additionally, Runx proteins did not affect proliferation rates in this chondrocyte cell line.
17
Joshi, Mahesh Raj. "The psychophysical characterisation of dorsal and ventral stream functions with equivalent noise paradigm normal clinical populations." Thesis, Glasgow Caledonian University, 2016. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.726786.
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LeBlanc, Kimberly T. "Runx Expression in Normal and Osteoarthritic Cartilage: Possible Functions of Runx Proteins in Chondrocytes: A Dissertation." eScholarship@UMMS, 2013. https://escholarship.umassmed.edu/gsbs_diss/655.
Full textAbstract:
The Runx family of transcription factors supports cell fate determination, cell cycle regulation, global protein synthesis control, and genetic as well as epigenetic regulation of target genes. Runx1, which is essential for hematopoiesis; Runx2, which is required for osteoblast differentiation; and Runx3, which is involved in neurologic and gut development; are expressed in the growth plate during chondrocyte maturation, and in the chondrocytes of permanent cartilage structures. While Runx2 is known to control genes that contribute to chondrocyte hypertrophy, the functions of Runx1 and Runx3 during chondrogenesis and in cartilage tissue have been less well studied.
The goals of this project were to characterize expression of Runx proteins in articular cartilage and differentiating chondrocytes and to determine the contribution of Runx1 to osteoarthritis (OA). Here, the expression pattern of Runx1 and Runx2 was characterized in normal bovine articular cartilage. Runx2 is expressed at higher levels in deep zone chondrocytes, while Runx1 is primarily expressed in superficial zone chondrocytes, which is the single cell layer that lines the surface of articular cartilage. Based on this finding, the hypothesis was tested that Runx1 is involved in osteoarthritis, which is a disease characterized by degradation of articular cartilage and changes in chondrocytes. These studies showed that Runx1 is upregulated in articular cartilage explants in response to mechanical compression. Runx1 was also expressed in chondrocytes found at the periphery of OA lesions in the articular cartilage of mice that underwent an OA-inducing surgery. Runx1 was also upregulated in cartilage explants of human osteoarthritic knees, and IHC data showed that Runx1 is mainly expressed in chondrocyte “clones” characteristic of OA.
To ascertain the potential function of the upregulation of Runx1 in these cartilage stress conditions and disease states, the hypothesis was tested that Runx1 is upregulated in very specific chondrocyte populations in response to the cartilage damage in osteoarthritis. These studies addressed the properties of these cells that related to functions in cell growth and differentiation. In both the surface layer of normal articular cartilage, and in OA cartilage, Runx1 expression by IF co-localized with markers of mesenchymal progenitor cells, as well as markers of proliferation Ki-67 and PCNA. This finding indicated that Runx1 is found in a population of cells that represent a proliferative population of mesenchymal progenitor cells in osteoarthritis.
To further address Runx1 function and identify downstream targets of Runx proteins, a promoter analysis of genes that are known to be either downregulated or upregulated during chondrocyte maturation was done. These studies found that many of these genes have 1 or more Runx binding sites within 2kb of their transcription start site, indicating that they are potential downstream Runx target genes.
Lastly, some preliminary experiments were done to characterize novel roles of Runx proteins in the chondrocyte. Runx proteins have been shown to epigenetically regulate their target genes by remaining bound to them throughout mitosis, “poising” them for transcription upon exit from mitosis. The hypothesis that Runx proteins also function by remaining bound to their target genes throughout mitosis in chondrocytes was tested. It was demonstrated by immunofluorescense imaging of Runx proteins on metaphase chromosomes of ATDC5 cells, that Runx2 remains bound to chromosomes during mitosis.
Cell proliferation and hypertrophy are both linked to increases in protein synthesis. Runx factors, which regulate rates of global protein synthesis, are expressed in both proliferating and hypertrophic chondrocytes. Thus, it was hypothesized that Runx proteins regulate rates of global protein synthesis during chondrocyte maturation. These studies showed that the overexpression of Runx proteins in a chondrocyte cell line (ATDC5) did not affect protein synthesis rates or levels of protein synthesis machinery. Additionally, Runx proteins did not affect proliferation rates in this chondrocyte cell line.
19
Tombari, Francesca. "Deformation of surfaces in 2D persistent homology." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2018. http://amslaurea.unibo.it/15809/.
Full textAbstract:
In the context of 2D persistent homology a new metric has been recently introduced, the coherent matching distance. In order to study this metric, the filtering function is required to present particular “regularity” properties, based on a geometrical construction of the real plane, called extended Pareto grid. This dissertation shows a new result for modifying the extended Pareto grid associated to a filtering function defined on a smooth closed surface, with values in the real plane. In future, the technical result presented here could be used to prove the genericity of the regularity conditions assumed for the filtering function.
20
Vahlne, Gustaf. "Natural killer cell inhibitory and activating receptors : regulatory role in effector functions against normal and tumor cells /." Stockholm : Karolinska institutet, 2007. http://diss.kib.ki.se/2007/978-91-7357-430-3/.
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Depatie, Lana. "The effect of nicotine on different paradigns of attentional and oculomotor functions in Schizophrenia patients and normal controls /." Thesis, McGill University, 2001. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=32989.
Full textAbstract:
Schizophrenic patients have a high prevalence of smoking. It has been postulated that this may be related to the positive effect of nicotine on cognition. We evaluated the effect of nicotine on attention and eye movements, domains in which schizophrenic patients have robust deficits. Patients (n = 19) who met DSM-IV criteria for schizophrenia and Controls (n = 15) were given a Nicoderm 14 mg patch in a double-blind, placebo-controlled, crossover design, and performance on various attention tasks (Continuous Performance Task (CPT), Stroop, Treisman, Dixon-Lupien), and oculomotor tasks (fixation, smooth pursuit, saccades and antisaccade) was assessed. Nicotine significantly improved attention (CPT hit rate) in patients (p < 0.02) and not in controls. Nicotine increased pursuit gain (p < 0.01) and decreased antisaccade errors (p < 0.01) in patients and controls equally. The magnitude of the improvement on eye movement and attention tasks did not correlate with plasma nicotine concentration (measured by RIA). We conclude that nicotinic mechanisms modulate attention and oculomotor functions and that the effect of nicotine on pursuit may be mediated by attention.
22
Teixeira, Lopes André [Verfasser], and Matthias [Akademischer Betreuer] Kneussel. "Spastin regulates microtubule dynamics and is required for normal motor and cognitive functions / André Teixeira Lopes ; Betreuer: Matthias Kneussel." Hamburg : Staats- und Universitätsbibliothek Hamburg, 2018. http://d-nb.info/1160675791/34.
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Parrish, Linda Titera. "The Effect of Age, Noise Level, and Frequency on Loudness Matching Functions of Normal Hearing Listeners with Noise Masking." BYU ScholarsArchive, 2016. https://scholarsarchive.byu.edu/etd/5793.
Full textAbstract:
Loudness recruitment is an abnormally rapid growth of perceived loudness above the hearing threshold that slows to normal growth as the intensity of the signal increases. Recruitment is common in sensorineural hearing loss and in simulated hearing loss with noise masking. This study looked at possible differences in loudness recruitment with age, noise level, and frequency. Participants from two age groups were tested. Group A included participants aged 18 to 30 years and Group B included participants aged 50 to 75 years. Participants practiced the Alternate Binaural Loudness Balance (ABLB) test without noise present. They then repeated the tests with masking noise. Tests were completed with two different noise levels (50 dB SPL and 70 dB SPL), and two different test tone frequencies (1000 Hz and 2000 Hz). Participants identified loudness matching points to reference intensities of 20, 40, 60, and 80 dB HL. Participants completed 3 trials at each intensity level. Difference scores of the intensity of the loudness matching point minus the intensity of the reference tone were computed and analyzed statistically. An analysis of variance (ANOVA) for repeated measures fails to show significance for between-subjects effect for age, within subject effect for frequency, and trial. An ANOVA for repeated measures shows significant within subject effect for noise and for intensity. The 70 dB SPL noise level shows greater difference scores and a steeper loudness matching function slope than the 50 dB SPL noise level. The greater difference scores and steeper slope are expected due to the higher hearing threshold created with the higher noise level. As the intensity level increases, the difference score decreases. The decrease in difference scores with increasing intensity levels shows the presence of loudness recruitment. The results of this study suggest the use of masking noise in order to measure recruitment is an acceptable simulation. Age alone does not account for changes in loudness recruitment. Therefore, recruitment measurement with noise masking may be a potential marker of early auditory dysfunction.
24
Thullberg, Minna. "The cell cycle regulators p15, p16, p18 and p19 : functions and regulation during normal cell cycle and in multistep carcinogenesis /." Stockholm, 2000. http://diss.kib.ki.se/2000/91-628-4432-6/.
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Wong, Man Sze. "The Presence of Binaural Interaction Component (BIC) in the Auditory Brainstem Response (ABR) of Normal Hearing Adults." Scholar Commons, 2002. https://scholarcommons.usf.edu/etd/1533.
Full textAbstract:
The purpose of this study was to determine the prevalence of the binaural interaction component (BIC) in a large sample of normal hearing adults, and to measure the absolute latency and amplitude of the BIC as a function of the click rate of the stimulus and the electrode montage. The BIC is obtained by subtracting the auditory evoked potential waveform obtained with binaural stimulation from the waveform obtained by adding the responses from the left and right monaural stimulation. The tested hypothesis was that the recordings of the BIC vary among normal hearing individuals, and BIC latency and amplitude values change as a function of stimulus rate. Studies of the BIC help to explain the neural correlates of some binaural processes, and to develop an electrophysiological index of binaural processes for objective clinical evaluations.
Data was completed and analyzed on 47 adults between the ages of 20 and 41 (mean = 25) with hearing in the normal range (thresholds less than or equal to 20 dB HL at 500, 1000, 2000, and 4000 Hz in each ear) and no known neurological disorders. The results revealed a great variability in BIC morphology between subjects. The BIC waveforms were categorized into five distinct groups according to the number of positive and negative peaks present. Chi-square analyses revealed a significant relationship between click rate and BIC category; however, the relationship between recording montage and BIC category was insignificant. An Analysis of Variance (ANOVAs) revealed a significant increase in absolute latency and decrease in absolute amplitude of both negative and positive peaks as click rate increased from 7.7/s to 57.7/s. The results did not reveal a significant change in the type of BIC as an effect of electrode montage.
In conclusion, the BIC within the binaural difference waveform may be obtained in the majority of young individuals with normal hearing. Specifically, a slower stimulus rate revealed more components of the waveform, as well as an improvement in the morphology of the BIC compared to a faster stimulus rate. As these findings may aid in the development of an electrophysiological index of binaural neural processes in young individuals with normal hearing, more research should be attempted in the study of BIC in other age groups and patients with different audiograms.
26
Lopez, Olivier. "Contributions à l'analyse convexe sequentielle." Thesis, Montpellier 2, 2010. http://www.theses.fr/2010MON20170.
Full textAbstract:
Les premiers résultats en analyse convexe ne nécessitant aucune condition de qualification datent à peu près d'une quinzaine d'années et constituent le début de l'analyse convexe séquentielle. Ils concernaient essentiellement: la somme d'un nombre fini de fonctions convexes, la composition avec une application vectorielle convexe, et les problèmes de programmation mathématique convexe. Cette thèse apporte un ensemble de contributions à l'analyse convexe séquentielle. La première partie de la thèse est consacrée à l'obtention sans condition de qualification de règles de calcul sous-differentiel exprimées séquentiellement. On considère les cas suivants:l'enveloppe supérieure d'une famille quelconque de fonctions convexes semi-continues inférieurement définies sur un espace de Banach; une fonctionnelle intégrale convexe générale définie sur un espace de fonctions intégrales;la somme continue (ou intégrale) de fonctions convexes semi-continues inférieurement définies sur un espace de Banach séparable. Dans la deuxième partie on établit sans hypothèse de qualification sur les données du problème, des conditions nécessaires et suffisantes d'optimalité séquentielle pour divers types de problèmes d'optimisation et de contrôle optimal discret ou continuThe first results in convex analysis without any qualificationcondition have been established fifteen years ago, and one may say thatsequential convex analysis began with those results. They essentially concerned:The finite sum of convex functions, the composition with a vectorvaluedconvex mapping, and convex mathematical programming. The firstpart of this dissertation provides several contibutions to sequential convexanalysis. The following cases are considered: the upper envelop of a familyof lower semicontinuous convex functions; the integral functional overan integral space; the continuous sum of lower semicontinuous convex functions.In the second part, necessary and sufficient optimality conditions areestablished in sequential form for many types of programming problems anddicrete or continuous optimal control problems
27
Jahani, Masoumeh. "Computer simulation of the osteocyte and bone lining cell network and the effect of normal physiological changes in cellular functions on that network." Thesis, University of Hull, 2012. http://hydra.hull.ac.uk/resources/hull:7112.
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Osteocytes play a critical role in the regulation of bone remodelling by translating strain due to mechanical loading into biochemical signals transmitted through the interconnecting lacuno-canalicular network to bone lining cells (BLCs) on the bone surface. This work aims to examine the effects of disruption of that intercellular communication by simulation of osteocyte apoptosis and microcrack in the bone matrix. A model of a uniformly distributed osteocyte network has been developed that stimulates the signalling through the network to the BLCs based on strain level. Bi-directional and asymmetric communication between neighbouring osteocytes and BLCs is included; with propagation of the signal through the network gradually decreasing by a calcium decay factor. The effect of osteocyte apoptosis and microcracks are then examined by preventing signalling at and through the affected cells. It is found that a small percentage of apoptotic cells and tiny microcracks both lead to a significant reduction in the peak signal at the BLCs. The simulation shows that either apoptosis of only 3% of the osteocyte cells or tiny microcrack of 42μm, 42μm below the surface leads to a significant reduction in the peak signal at the BLCs. Furthermore, experiments with the model confirm how important the location and density of the apoptotic osteocytes are to the signalling received at the bone surface. The result also shows the importance of the location and length of microcrack on the signalling of BLC. The first may explain a possible mechanism leading to increased remodelling activity observed with osteoporosis, and the second, the mechanism driving normal bone remodelling and maintenance.
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Froger, Charlotte. "Déclin de la mémoire au cours du vieillissement normal : étude des médiateurs du déficit des processus stratégiques." Thesis, Tours, 2010. http://www.theses.fr/2010TOUR2013/document.
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L’objectif de ce travail était d’appréhender le déficit associatif en mémoire épisodique des adultes âgés en termes de déclin des processus stratégiques. Comme composantes du déficit lié à l’âge des processus stratégiques, nous avons étudié les stratégies de mémoire en tant qu’opérations contrôlées, puis dans le cadre de la métamémoire en tant que processus de régulation, et finalement selon une approche neuropsychologique nous avons considéré le fonctionnement exécutivo-frontal comme élément essentiel de la mise en œuvre de stratégies mnésiques. L’ensemble des résultats suggère que le déficit associatif des adultes âgés est en partie dû à leur diminution des capacités d’initiation, d’exécution et d’adaptation de stratégies lors de l’encodage et de la récupération. En outre, le dysfonctionnement exécutif des adultes âgés limiterait leur capacité d’exploiter efficacement une stratégie mise en œuvre à l’apprentissage et à la récupération. Toutefois, l’augmentation de la quantité de support cognitif et l’amélioration de la qualité de ce dernier a permis de compenser leur déficit associatif en mémoire épisodique. Globalement, ce travail suggère que les adultes âgés bénéficieraient d’une réserve cognitive qui leur permettrait, à condition de support et d’entraînement cognitif, de compenser en partie leur déficit associatif en mémoire épisodiqueThe main goal of this thesis was to evaluate the age-related associative memory deficit in terms of encoding and retrieval strategies impairment. We studied memory strategies in terms of control processes, then within metamemory framework in terms of regulation process, and finally according to a neuropsychological approach we considered the executive control as a critical factor in the implementation of memory strategies. Results suggest that the age-related associative deficit is partly due to their reduction of the abilities of initiation, implementation and adaptation of strategies during encoding and retrieval. Moreover, the age-related executive dysfunction would restrict their ability to exploit efficiently a strategy implemented during encoding and/or retrieval. Nevertheless, the increase of the quantity of cognitive support and the improvement of its quality allowed compensating their associative deficit in episodic memory. Finally, this thesis suggests that older adults benefit from cognitive plasticity which would allow them, on the condition of support and on cognitive training, partly compensating their associative memory deficit
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Auzou, Nicolas. "Production du verbe dans le vieillissement normal et les pathologies du mouvement : analyses quantitatives et qualitatives." Thesis, Bordeaux, 2018. http://www.theses.fr/2018BORD0304.
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L’objectif général de cette thèse est d’étudier la production quantitative (i.e., nombre de mots) et qualitative (i.e. regroupements et alternances) du verbe d’action dans le vieillissement normal et dans les pathologies du mouvement à travers la tâche de fluence d’action, comparativement aux fluences classiques (i.e., sémantique et littérale). Nous avons montré que la production lors d’une tâche de fluence d’action est altérée chez des adultes âgés (60 ans et plus) comparativement à des adultes jeunes (30 ans et moins) et qu’elle est en lien avec les fonctions exécutives (Expérience 1) et la mémoire de travail (Expérience 3) chez l’adulte âgé. L’effet de l’âge paraît être modifié par le temps de production, les adultes âgés produisant moins de verbes d’action que les adultes jeunes pour un temps de trois minutes (Expérience 1) mais pas pour des temps d’une (Expérience 2) et de deux minutes (Expérience 3). De plus, les adultes âgés prenaient davantage en considération la consigne temporelle lors des tâches de fluence verbale que les adultes jeunes (Expérience 2). Les données d’une tâche d’association verbale (Expérience 4) indiquaient que les associations entre les noms et les verbes sont modifiées par l’âge. Nous avons comparés les performances de patients atteints de pathologiesdu mouvement à celles de participants contrôles lors de la tâche de fluence d’action. Nous avons montré que la production quantitative lors cette tâche est altérée chez des patients atteints de maladie de Parkinson (Expérience 5) et d’atrophie multisystématisée (Expérience 6). Dans le tremblement essentiel (Expérience 7), nous avons montré une atteinte de la fluence d’action alors que le traitement des verbes, lors d’une tâche de décision lexicale, n’était pas altéré. De plus, la chirurgie (stimulation cérébrale profonde) modifiait qualitativement la production dans la tâche de fluence d’action. Nos données montrent un impact du vieillissement normal et des pathologies du mouvement sur la production du verbe d’action, enraison de la nature fortement exécutive de ce processusThe aim of this thesis is to investigate the production of action verbs through the action fluency task, in comparison to classical fluency tasks (i.e., semantic and letter). In first instance, production has been studied, both quantitatively and qualitatively, in aging. We have shown that action fluency is impacted by healthy aging and is related to executive functions (Experiment 1) and working memory (Experiment 3) in older adults. This effect of age appearsto be affected by production time, with older adults producing fewer action verbs than younger adults in three minutes (Experiment 1) but not in one (Experiment 2) and two minutes (Experiment 3). In addition, older adults took more into account the time instruction during verbal fluency tasks (Experiment 2). The verbal association task’s data (Experiment 4) indicated that associations between nouns and verbs are modified by age. In second instance,the production of action verbs has been studied within movement disorders. We have shown that the production in the action fluency task and the adaptation to time instruction are impacted by Parkinson's disease (Experiment 5). We have also shown that action fluency is altered within an atypical parkinsonism, multiple system atrophy (Experiment 6). In essential tremor (Experiment 7), we have shown an impairment of action fluency while verbs treatment, in a lexical decision task, was not altered. In addition, surgery (deep brain stimulation) qualitatively modified the production of verbs in action fluency. Our data highlight the impact of healthy aging and movement disorders on the production of action verb, due to the highly executive nature of this process
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Thompson, Scotty L. "Comparing Topological Spaces Using New Approaches to Cleavability." View abstract, 2009. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pqdiss&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&rft_dat=xri:pqdiss:3372574.
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Michalon, Sonia. "Etude des fonctions frontales dans la maladie d’Alzheimer : impact sur l’autonomie et les interactions communicationnelles Impact des fonctions frontales sur les activités de la vie quotidienne dans la maladie d’Alzheimer." Thesis, Angers, 2018. http://www.theses.fr/2018ANGE0073.
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L’objectif de ce travail de thèse est d’enrichir la présentation clinique des troubles neurocognitifs d’origine frontale à travers l’évaluation des fonctions frontales et des interactions communicationnelles dans la maladie d’Alzheimer. Nous proposons une approche intégrée du fonctionnement exécutif, qui sort des études cloisonnées et singulières qui ne permettent pas une approche globale de l’ensemble des compétences supportées par les lobes frontaux. Le fonctionnement frontal est essentiel à la fois pour agir sur l’environnement mais également pour être adapté socialement. Les perturbations observées sur le plan comportemental peuvent donc être différentes selon la région cérébrale modifiée ou lésée (Stuss et al., 2002), amenant à la nécessité d’intégrer la notion de fractionnement du fonctionnement frontal dans les modélisations théoriques (Stuss & Alexander, 2007). Pour cela, nous nous sommes appuyées sur le modèle neuroanatomique du fonctionnement frontal proposé par Stuss (2011) pour mieux comprendre les modifications comportementales, socio-émotionnelles et cognitives des personnes avec maladie d’Alzheimer ; considérant que, jusqu’à présent, aucun travail n’a permis d’évaluer conjointement ces habiletés à partir d’un même échantillon de personnes atteintes de maladie d’Alzheimer.Afin de mieux cerner la dimension pathologique, nous analyserons les performances obtenues dans la maladie d’Alzheimer, mais également en contexte de vieillissement normal. Puis, nous chercherons à mieux comprendre l’impact du fonctionnement frontal sur la perte d’autonomie et l’isolement social. Enfin, nous verrons les liens qu’entretiennent les fonctions frontales et la communication, ce qui nous amènera à mieux cerner les composantes nécessaires au succès des interactions sociales et communicationnelles, et ce, afin de proposer des pistes d’interventions adaptéesThe aim of our PhD work is to enrich the clinical presentation of frontal origin neurocognitive disorders through the assessment of frontal functions and communicational interactions in Alzheimer's disease. We propose an integrated approach of executive functioning, which comes out of isolated and singular studies that do not allow a global approach of all the competences supported by the frontal lobes. Executive functioning is essential to act on the environment but also to be adapted socially. Behavioral disturbances can therefore be different according to the modified or injured brain region (Stuss et al., 2002), leading to the need of integrating the notion of fractional frontal operation in theoretical models (Stuss & Alexander, 2007). Thus, we relied on the neuroanatomical model of frontal functions proposed by Stuss (2011) to better understand the behavioral, socioemotional and cognitive changes in people with Alzheimer disease; Actually, until now, no work has allowed to assess all these skills from the same sample of people with Alzheimer disease. To have a better understanding of the pathological dimensions, we will analyze the performances obtained in Alzheimer's disease, but also in the context of normal aging. Then, we will search the impact of the frontal functions on the loss of autonomy and social isolation. Finally, we will point out the links between the frontal functions and the communication, which will lead us to a better identification of the components necessary to the success of the social and communication interactions, and this, to propose adapted ways of interventions
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Gaunt, Robert E. "Rates of convergence of variance-gamma approximations via Stein's method." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:5ddc6def-5821-4e72-8784-cfe2dc8b6c03.
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Stein's method is a powerful technique that can be used to obtain bounds for approximation errors in a weak convergence setting. The method has been used to obtain approximation results for a number of distributions, such as the normal, Poisson and Gamma distributions. A major strength of the method is that it is often relatively straightforward to apply it to problems involving dependent random variables. In this thesis, we consider the adaptation of Stein's method to the class of Variance-Gamma distributions. We obtain a Stein equation for the Variance-Gamma distributions. Uniform bounds for the solution of the Symmetric Variance-Gamma Stein equation and its first four derivatives are given in terms of the supremum norms of derivatives of the test function. New formulas and inequalities for modified Bessel functions are obtained, which allow us to obtain these bounds. We then use local approach couplings to obtain bounds on the error in approximating two asymptotically Variance-Gamma distributed statistics by their limiting distribution. In both cases, we obtain a convergence rate of order n-1 for suitably smooth test functions. The product of two normal random variables has a Variance-Gamma distribution and this leads us to consider the development of Stein's method to the product of r independent mean-zero normal random variables. An elegant Stein equation is obtained, which motivates a generalisation of the zero bias transformation. This new transformation has a number of interesting properties, which we exploit to prove some limit theorems for statistics that are asymptotically distributed as the product of two central normal distributions. The Variance-Gamma and Product Normal distributions arise as functions of the multivariate normal distribution. We end this thesis by demonstrating how the multivariate normal Stein equation can be used to prove limit theorems for statistics that are asymptotically distributed as a function of the multivariate normal distribution. We establish some sufficient conditions for convergence rates to be of order n-1 for smooth test functions, and thus faster than the O(n-1/2) rate that would arise from the Berry-Esseen Theorem. We apply the multivariate normal Stein equation approach to prove Variance-Gamma and Product Normal limit theorems, and we also consider an application to Friedman's X2 statistic.
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Calso, Cristina. "Étude du vieillissement normal des fonctions frontales : impact sur l’autonomie et la qualité de vie." Thesis, Angers, 2017. http://www.theses.fr/2017ANGE0026/document.
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En s’appuyant sur l’hypothèse frontale du vieillissement (West, 1996), ce travail vise à évaluer le vieillissement normal de capacités frontales (contrôle exécutif, prise de décision, énergisation, métacognition ; Stuss, 2008)et à analyser les liens éventuels entre ces habiletés,l’autonomie et la qualité de vie des aînés. Quarante personnes jeunes (26±5 ans), 40 âgées (68,7±3,7 ans)et 30 très âgées (83,4±3,5 ans) en bonne santé ont participé à notre étude. Les aînés ne montraient pas de traits dépressifs/anxieux, ni de déclin cognitif typiques d’un vieillissement pathologique. Ils présentaient une autonomie et une qualité de vie satisfaisantes.Certaines habiletés cognitives semblent se détériorer après 65 ans (flexibilité, énergisation, prise de décision sous risque explicite, théorie de l’esprit, détection de la coopération/tromperie), d’autres après 80 ans (fluence verbale, mémoire épisodique, dénomination, inhibition,prise de décision en situation ambiguë), d’autres encore seraient préservées (lecture, rappel immédiat,réalisation de tâches de flexibilité spontanée et de temps de réaction simple). La conscience que les sujets ont d’eux-mêmes dépendrait de leur âge. Trois profils distincts de fonctionnement frontal ont été décrits pour chaque groupe de participants, montrant une variabilité intra groupe importante. Le niveau d’autonomie des personnes âgées serait associé au contrôle exécutif,celui de qualité de vie à l’énergisation et à la métacognition. Ces résultats vérifient partiellement nos hypothèses et conduisent à envisager le développement de programmes d’entraînement cognitif multidimensionnels, susceptibles d’influencer la sphère personnelle des aînésStarting from the “frontal lobe hypothesis of cognitive aging” (West, 1996), the main objective of this work is to study frontal lobe functions (executive control, decision making,energization, metacognition; Stuss, 2008) and their possible associations with levels of autonomy and quality of life in normal aging. Forty young adults (26±5years), forty old adults (68,7±3,7 years) and thirty very old adults (83,4±3,5 years) participated to our study.These healthy subjects didn’t show any depressive/anxious symptoms and global cognitive decline, which are frequently observed in pathologic alaging. They have a good level of autonomy and general satisfaction of life. A number of frontal lobe abilities seem to decrease after 65 years old (flexibility,energization, explicit decision-making, theory of mind,detection of cooperative and deceptive situations).Other functions decline after 80 years old (verbalfluency, episodic memory, naming, inhibition, implicit decision-making). Reading, immediate recall, realization of spontaneous flexibility and simple reaction time tasks are preserved with aging. Self-consciousness seems to depend on individuals’ age. We have described three different clusters of the frontal functioning for each group of participants, showing the existence of animportant intragroup variability. Old adults’ level of autonomy seems to be associated with the executive control, old adults’ quality of life correlated with the energization and metacognitive functions. These resultsconfirm in part our hypothesis and support the development of multidimensional cognitive training programs, which could impact old adults’ personal sphere
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Askew, Sandra Lyn. "Cytokine signalling functions of human soluble IgE receptors in peripheral blood mononuclear cells from normal and hyper-allergic individuals and in B-lymphoblastoid and monocytic cell lines." Thesis, Nelson Mandela Metropolitan University, 2006. http://hdl.handle.net/10948/455.
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CD23 is a multifunctional receptor/ligand, found in a variety of cell types, such as human peripheral blood mononuclear cells (PBMCs), B-lymphoblastoid cell lines, mast cells and basophils. It is also found on a variety of haematopoietic cell lines. As the low-affinity receptor for immunoglobulin E (IgE), CD23 plays a role in antigen-presentation and macrophage activation. As a surface molecule cleaved from the cell membrane, soluble CD23 (sCD23) can act as an adhesion molecule and a cytokine. Perturbances of such molecular interactions may lead to various diseases such as allergies and other inflammatory diseases. It has been speculated that elevated levels of sCD23 may be used to bind secreted IgE, thus preventing it from binding to membrane CD23 on haematopoietic cells, preventing B cells from being activated into IgE producing cells. Signal transduction by sCD23 is dependent on cell subsets, ligands and co-factors required for its function. sCD23 plays a direct role in inducing tumour necrosis factor alpha (TNFα), interleukin-1 alpha (IL-1α) and interleukin-1 beta (IL-1β) and soluble IL-1 receptor from activated human monocytes and PBMCs in vitro. Recombinant forms of 25 and 37 kDa human sCD23 were produced by polymerase chain reaction (PCR)-cloning into pET23a, a bacterial expression vector. The proteins were expressed and refolded, followed by purification by gel filtration chromatography. The purified proteins were biochemically characterized to ensure purity and biological activity, by observing the binding to human IgE both in enzyme-linked immunosorbant assay (ELISA) and surface plasmon resonance (SPR) spectroscopy. ELISA showed KD values of 7.23 x 10-9M and 8.12 x 10-9M for the 25 and 37 kDa proteins, respectively. These values were significantly lower than that of Hibbert et al., (2005). SPR data obtained for the 25 kDa CD23 was not of reliable quality but SPR for the 33kDa sCD23 showed a KD of 1.18 x 10-7M, close to that of Hibbert et al., (2005), J. Exp. Med, 202: 751-760. To test the therapeutic potential of the recombinant molecule, a B-lymphoblastoid cell line (Raji), a pre-monocytic cell line (U937), and PBMCs from normal and hyper-allergic individuals were used. All cells showed no change in production of cytokines. It is essential to investigate further cytokine functions and production implicated by recombinant forms of sCD23, as well as binding of sCD23 to CD21 and CD11b/c, and in vivo IgE regulation before a conclusion can be drawn as to whether recombinant sCD23 is a potential therapeutic target against allergic disease.
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Tonini, Audrey. "Fonctionnement émotionnel et socio-cognitif dans le vieillissement normal et le Mild Cognitive Impairment. : apport de la validation française du Barrow Neurological Institute Screen for higher cerebral functions." Thesis, Paris 8, 2014. http://www.theses.fr/2014PA080002.
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Ce travail de thèse s’articule autour de trois études complémentaires. La première aborde la validation française d’un test rapide d’évaluation des fonctions supérieures: le Barrow Neurological Institute Screen for higher cerebral functions (B.N.I.S). Cette étude a permis de rendre disponible en langue française un outil rapide qui évalue les fonctions cognitives classiques mais aussi les capacités émotionnelles et sociocognitives, fonctions généralement non intégrées dans ce type de test. La seconde étude, menée auprès de participants présentant un Mild Cognitive Impairment (M.C.I), a ensuite permis de mettre en évidence la nécessité de prendre en compte l’évaluation émotionnelle. Les participants M.C.I présentent un profil spécifique au B.N.I.S., notamment aux subtests d’affectivité, d’orientation, de mémoire et d’auto-évaluation de la performance mnésique. Enfin, la troisième étude analyse les performances de reconnaissance faciale des émotions et de raisonnement social au cours du vieillissement normal, le Mild Cognitive Impairment et la démence de type Alzheimer (DTA) au stade débutant. Nous observons un déclin des capacités de reconnaissance faciale des émotions et de raisonnement social au cours du vieillissement normal qui s’accentue significativement au cours de la DTA. Un profil spécifique est retrouvé pour le M.C.I avec un déclin en raisonnement social mais des capacités de reconnaissance faciale émotionnelle comparables aux sujets âgés du groupe contrôle. L’évaluation des capacités émotionnelles devrait être davantage intégrée aux bilans neuropsychologiques afin de mieux orienter les modalités de prise en charge de la population vieillissanteThis research presents three complementary studies: (1) the french validation of the Barrow Neurological Institute Screen for higher cerebral functions (B.N.I.S), developed by G. Prigatano in 1991. We have assessed 167 subjects from 15 to 84 years within a french population. The goal is :1) to promote a new short screening instrument dedicated to cognitive and emotional functions, usually emotional functions are not integrated in neuropsychological assessments ; (2) to apply the B.N.I.S to Mild Cognitive Impairment (M.C.I) subjects (N=39) in order to highlighted the importance of the emotional assessment in this type of population and found a specific profile at the substests named: affectivity, orientation, memory and self-assessment of the mnesic performance ; (3) to analyze, with more precision, the performance of emotional facial recognition and social reasoning during normal ageing (N=54), M.C.I (N=25) and Alzheimer disease (AD) at the early stage (N=17). A decline of sociocognitive capacities is observed during the ageing and seems to become more important during the course of M.C.I and the AD. A specific profile was found for each group. The assessment of emotional capacities seems relevant and should be more integrated into the neuropsychological assessments, in order to improve diagnosis and to propose the best modalities of care for the ageing population
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Шоман, Ольга Вікторівна. "Геометричне моделювання узагальнених паралельних множин." Thesis, Київський державний технічний університет будівництва i архітектури, 2007. http://repository.kpi.kharkov.ua/handle/KhPI-Press/20365.
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Дисертація на здобуття наукового ступеня доктора технічних наук зі спеціальності 05.01.01 – Прикладна геометрія, інженерна графіка. – Київський національний університет будівництва і архітектури, Київ, 2007. Дисертацію присвячено розробці теорії геометричного моделювання узагальнених паралельних множин для розв'язання задач формоутворення в часі геометричних об'єктів – наочних геометричних моделей динамічних явищ і процесів, що характеризуються хвильовими фронтами, поверхні яких у певні моменти часу утворюють просторову конформну сітку з лініями у напрямках руху цих фронтів, або характеризуються ізолініями, конформними до напрямків зміни фізичних параметрів. На основі введеної термінології запропоновано загальний підхід до геометричного моделювання проявів процесів і явищ різної фізичної природи. Розроблено теоретичні основи методу опису геометричних моделей паралельних множин на площині за допомогою рівнянь Гамільтона – Якобі у вигляді рівняння ейконала для кривих, що мають точки звороту або самі себе перетинають; методу опису геометричних моделей паралельних множин за допомогою нормальних рівнянь для поверхонь, які задано у параметричному вигляді; методу на основі конформних відображень, в якому запропоновано новий геометричний зміст функції комплексного потенціалу вихору і одержано нові геометричні моделі сімей квазіпаралельних ліній на комплексній площині. Удосконалено метод іміджевої екстраполяції для прогнозування геометричної форми ліній на площині, як елементів узагальнених паралельних множин. Розроблені методи дозволяють вивчати якісні зміни об'єктів, що моделюються.Thesis for a doctor's degree in engineering sciences. Specialty: 05.01.01 – Applied geometry, engineering graphics. – Kyiv National University of Building and Architecture. – Kyiv, 2007. The dissertation is devoted to developing of the geometrical modelling theory of the general parallel sets for problems solving of geometrical objects form-formation in time which are visual geometrical models of dynamic phenomena and processes characterized by wave fronts surfaces which create the space conformal set in the moments of time with the lines on directions of these fronts moving or by isolines which are conformal to directions of physical parameters change. On introduced terminology basis the general approach to the geometrical modelling of different origin physical phenomena and processes displays is proposed. It was developed the theoretical basis of: the method of parallel sets geometrical models creation on the plane by means of Hamilton – Jacobi equation as eikonal equation for the curves with return and self-intersection points; the method of parallel sets geometrical models creation by means of normal equations for the surfaces in parameter form; the method based on conformal representations, in which the new geometrical meaning of twister complex potential function was proposed and the new geometrical models of quasi-parallel lines sets were obtained on the complex plane; the improved image extrapolation method for forecasting of geometrical form of lines on the plane as the elements of general parallel sets. These methods allow to research qualitative change of objects modelled.
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Tian, Hao. "A methodology for domain-specific conceptual data modeling and querying." restricted, 2007. http://etd.gsu.edu/theses/available/etd-02272007-140033/.
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Thesis (Ph. D.)--Georgia State University, 2007.Rajshekhar Sunderraman, committee chair; Paul S. Katz, Yanqing Zhang, Ying Zhu, committee members. Electronic text (128 p. : ill.) : digital, PDF file. Description based on contents viewed Oct. 15, 2007; title from file title page. Includes bibliographical references (p. 124-128).
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Nyarko-Adomfeh, Charles. "Cardiovascular function in normal man." Thesis, University of Nottingham, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.317595.
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Mohsen, Omar. "Deformation groupoids and applications." Thesis, Sorbonne Paris Cité, 2018. http://www.theses.fr/2018USPCC200/document.
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Cette thèse est consacrée à l’étude de trois questions différentes concernant les groupoïdes de Lie et leurs applications. Le premier chapitre présente quelques préliminaires sur les groupoïdes de Lie. Dans le chapitre 2, on exprime la déformation de Witten à l’aide d’une déformation au cone normal et la théorie de C∗-modules ce qui nous permet de retrouver les inégalités de Morse. Notre méthode se généralise au cas des feuilletages. Dans le chapitre 3, on donne une construction simple du groupoïde de déformation construit par Choi-Pönge et Van Erp-Yuncken. Rappelons que celui-ci décrit le calcule pseudo-différentiel inhomogène grâce au travail de Debord-Skandalis et Van Erp- Yuncken. Notre construction montre que le groupoïde de déformation est en fait une déformation au cone normal classique itérée. Dans le chapitre 4, suivant le travail de Antonini, Azzali et Skandalis, on construit un élément en KK-théorie équivariante qui permet d’exprimer directement les invariants de Chern-Simons en K-théorie. Dans l’appendice on donne quelques rappels sur la KK-théorie équivariante et la KK-théorie réelle introduite par Antonini, Azzali et SkandalisThis thesis is devoted to the study of three different questions concerning Lie groupoids and their applications. The first chapter presents some preliminaries on Lie groupoids. In Chapter 2, Witten’s deformation is expressed using deformation to the normal cone construction and the theory of C∗-modules, which allows us to reprove the Morse inequalities. Our method is generalised to the case of foliations. In Chapter 3, we give a simple construction of the deformation groupoid built by Choi-Pönge and Van Erp-Yuncken. Recall that this groupoid describes the inhomogeneous pseudo-differential calculus thanks to the work of Debord-Skandalis and Van Erp-Yuncken. Our construction shows that the deformation groupoid is actually an iterated classical deformation to the normal cone. In Chapter 4, following the work of Antonini, Azzali and Skandalis, we construct an element in equivariant KK-theory that allows us to express the Chern-Simons invariants directly in K-theory. In the appendix we give some reminders about the equivariant KK-theory and the real KK-theory introduced by Antonini, Azzali and Skandalis
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Sánchez, Luis Florial Espinoza. "Surfaces in 4-space from the affine differential geometry viewpoint." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/55/55135/tde-23032015-142340/.
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In this thesis, we study locally strictly convex surfaces from the affine differential viewpoint and generalize some tools for locally strictly submanifolds of codimension 2. We introduce a family of affine metrics on a locally strictly convex surface M in affine 4-space. Then, we define the symmetric and antisymmetric equiaffine planes associated with each metric. We show that if M is immersed in a locally atrictly convex hyperquadric, then the symmetric and the antisymmetric planes coincide and contain the affine normal to the hyperquadric. In particular, any surface immersed in a locally strictly convex hyperquadric is affine semiumbilical with respect to the symmetric or antisymmetric equiaffine planes. More generally, by using the metric of the transversal vector field on M we introduce the affine normal plane and the families of the affine distance and height functions on M. We show that the singularities of the family of the affine height functions appear at directions on the affine normal plane and the singularities of the family of the affine distance functions appear at points on the affine normal plane and the affine focal points correspond as degenerate singularities of the family of affine distance functions. Moreover we show that if M is immersed in a locally strictly convex hypersurface then the affine normal plane contains the affine normal vector to the hypersurface. Finally, we conclude that any surface immersed in a locally strictly convex hypersphere is affine semiumbilical.Nesta tese estudamos as superfícies localmente estritamente convexas desde o ponto de vista da geometria diferencial afim e generalizamos algumas ferramentas para subvariedades localmente estritamente convexas de codimensão 2. Introduzimos uma família de métricas afins sobre uma superfície localmente estritamente convexa M no 4-espaço afim. Então, definimos os planos equiafins simétrico e antissimétrico associados com alguma métrica. Mostramos que se M é imersa em uma hiperquádrica localmente estritamente convexa, então os planos simétrico e assimétrico são iguais e contêm o campo vetorial normal afim à hiperquádrica. Em particular, qualquer superfície imersa em uma hiperquádrica localmente estritamente convexa é semiumbílica afim com relação ao plano equiafim simétrico ou antissimétrico. Mais geralmente, usando a métrica do campo transversal sobre M introduzimos o plano normal afim e as famílias de funções distância e altura afim sobre M. Provamos que as singularidades da família de funções altura afim aparecem como direções do plano normal afim e as singularidades da família de funções distância afim aparecem como pontos sobre o plano normal afim e os pontos focais correspondem às singularidades degeneradas da família de funções distância afim. Também provamos que se M é uma superfície imersa em uma hipersuperfície localmente estritamente convexa, então o plano normal afim contém o vetor normal afim à hipersuperfície. Finalmente, concluímos que qualquer superfície imersa em uma hiperesfera localmente estritamente convexa é semiumbílica afim.
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Zakaryan, Taron. "Contribution à l'analyse variationnelle : stabilité des cônes tangents et normaux et convexité des ensembles de Chebyshev." Thesis, Dijon, 2014. http://www.theses.fr/2014DIJOS073/document.
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Le but de cette thèse est d'étudier les trois problèmes suivantes : 1) On s'intéresse à la stabilité des cônes normaux et des sous-différentiels via deux types de convergence d'ensembles et de fonctions : La convergence au sens de Mosco et celle d'Attouch-Wets. Les résultats obtenus peuvent être vus comme une extension du théorème d'Attouch aux fonctions non nécessairement convexes sur des espaces de Banach localement uniformément convexes. 2) Pour une bornologie β donnée sur un espace de Banach X, on étudie la validité de la formule suivante (…). Ici Tβ(C; x) et Tc(C; x) désignent le β -cône tangent et le cône tangent de Clarke à C en x. On montre que si, X x X est ∂β-« trusted » alors cette formule est valable pour tout ensemble fermé non vide C ⊂ X et x ∈ C. Cette classe d'espaces contient les espaces ayant une norme équivalent β-différentiable, etplus généralement les espaces possédant une fonction "bosse" lipschitzienne et β-différentiable). Comme conséquence, on obtient que pour la bornologie de Fréchet, cette formule caractérise les espaces d'Asplund. 3) On examine la convexité des ensembles de Chebyshev. Il est bien connu que, dans un espace normé réflexif ayant la propriété Kadec-Klee, tout ensemble de Chebyshev faiblement fermé est convexe. On démontre que la condition de faible fermeture peut être remplacée par la fermeture faible locale, c'est-à-dire pour tout x ∈ C il existe ∈ > 0 tel que C ∩ B(x, ε) est faiblement fermé. On montre aussi que la propriété Kadec-Klee n'est plus exigée lorsque l'ensemble de Chebyshev est représenté comme une union d'ensembles convexes fermésThe aim of this thesis is to study the following three problems: 1) We are concerned with the behavior of normal cones and subdifferentials with respect to two types of convergence of sets and functions: Mosco and Attouch-Wets convergences. Our analysis is devoted to proximal, Fréchet, and Mordukhovich limiting normal cones and subdifferentials. The results obtained can be seen as extensions of Attouch theorem to the context of non-convex functions on locally uniformly convex Banach space. 2) For a given bornology β on a Banach space X we are interested in the validity of the following "lim inf" formula (…).Here Tβ(C; x) and Tc(C; x) denote the β-tangent cone and the Clarke tangent cone to C at x. We proved that it holds true for every closed set C ⊂ X and any x ∈ C, provided that the space X x X is ∂β-trusted. The trustworthiness includes spaces with an equivalent β-differentiable norm or more generally with a Lipschitz β-differentiable bump function. As a consequence, we show that for the Fréchet bornology, this "lim inf" formula characterizes in fact the Asplund property of X. 3) We investigate the convexity of Chebyshev sets. It is well known that in a smooth reflexive Banach space with the Kadec-Klee property every weakly closed Chebyshev subset is convex. We prove that the condition of the weak closedness can be replaced by the local weak closedness, that is, for any x ∈ C there is ∈ > 0 such that C ∩ B(x, ε) is weakly closed. We also prove that the Kadec-Klee property is not required when the Chebyshev set is represented by a finite union of closed convex sets
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Al-Bashabsheh, Ali. "Normal Factor Graphs." Thèse, Université d'Ottawa / University of Ottawa, 2014. http://hdl.handle.net/10393/30659.
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This thesis introduces normal factor graphs under a new semantics, namely, the exterior function semantics. Initially, this work was motivated by two distinct lines of research. One line is ``holographic algorithms,'' a powerful approach introduced by Valiant for solving various counting problems in computer science; the other is ``normal graphs,'' an elegant framework proposed by Forney for representing codes defined on graphs. The nonrestrictive normality constraint enables the notion of holographic transformations for normal factor graphs. We establish a theorem, called the generalized Holant theorem, which relates a normal factor graph to its holographic transformation. We show that the generalized Holant theorem on one hand underlies the principle of holographic algorithms, and on the other reduces to a general duality theorem for normal factor graphs, a special case of which was first proved by Forney. As an application beyond Forney's duality, we show that the normal factor graphs duality facilitates the approximation of the partition function for the two-dimensional nearest-neighbor Potts model. In the course of our development, we formalize a new semantics for normal factor graphs, which highlights various linear algebraic properties that enables the use of normal factor graphs as a linear algebraic tool. Indeed, we demonstrate the ability of normal factor graphs to encode several concepts from linear algebra and present normal factor graphs as a generalization of ``trace diagrams.'' We illustrate, with examples, the workings of this framework and how several identities from linear algebra may be obtained using a simple graphical manipulation procedure called ``vertex merging/splitting.'' We also discuss translation association schemes with the aid of normal factor graphs, which we believe provides a simple approach to understanding the subject. Further, under the new semantics, normal factor graphs provide a probabilistic model that unifies several graphical models such as factor graphs, convolutional factor graphs, and cumulative distribution networks.
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Chen, Jian. "Bifurcations, Normal Forms and their Applications." Diss., Georgia Institute of Technology, 2005. http://hdl.handle.net/1853/7121.
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The first part is a study of an ecological model with one herbivore and $N$ plants. The system has a new type of functional response due to the speculation that the plants compete with each other and have different levels of toxin which inhibit the herbivore's ability to eat up to a certain amount. We first derive the model mathematically and then investigate, both analytically and numerically, the possible dynamics for this model, including the bifurcation and chaos. We also discuss the conditions under which all the species can coexist.
The second part is a study in the normal form theory. In particular, we study the relations between the normal forms and the first integrals in analytic vector fields. We are able to generalize one of Poincare's classical results on the nonexistence of first integrals in an
autonomous system. Then in the space of 2n-dimensional analytic autonomous systems with exactly n resonances and n functionally independent first integrals, we obtain some results related to the convergence and generic divergence of the normalizations. Lastly we give a new proof of the necessary and sufficient conditions for a planar Hamiltonian system to have an isochronous center.
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Cockell, Anna Patricia. "Material vascular function in normal pregnancy and preeclampsia." Thesis, King's College London (University of London), 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.265331.
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Bryan, Tina Michelle. "Testicular function in normal and poor semen quality stallions." Texas A&M University, 2004. http://hdl.handle.net/1969.1/3253.
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The chromosomal location of endocrine genes was established, and relationships between expression of specific endocrine genes and measures of testis function in normal and poor semen quality stallions was assessed. Consensus primer sequences for glucocorticoid receptor (GR) and luteinizing hormone receptor (LHR) were used to screen the CHORI-241 equine bacterial artificial chromosome (BAC) library. The identity of PCR-positive BAC clones was confirmed by sequencing. Verified BACs were mapped to horse metaphase chromosome spreads by fluorescence in situ hybridization (FISH). The BACs containing the GR and LHR were localized by FISH to ECA 14q16-q21 and ECA15q22-q23, respectively. In addition to FISH mapping, the 5000rad horse x hamster radiation hybrid (RH) panel was screened in duplicate. Two-point linkage analysis placed GR 0 cR from LEX047, while LHR was 36.67 cR from TKY011 on ECA14 and ECA15, respectively. Total testicular parenchymal weight, mean daily sperm production (DSP) per gram parenchyma and mean apoptotic rate (406.05 ± 24.33g vs. 180.01 ± 34.41g, 15.29 ± 0.87 vs. 10.24 ± 1.10, 6.70 ± 0.88 vs. 14.25 ± 1.11, respectively) differed (P<0.05) between normal (n=8) and poor semen quality (n=5) stallions. Also, plasma estradiol and inhibin concentrations were higher (P<0.05) in normal stallions than in poor semen quality stallions. Testicular expression
of estrogen receptor beta (ER beta), βB inhibin, prolactin receptor (PRLR), growth hormone receptor (GHR) and insulin-like growth factor I receptor (IGF-IR) mRNAs were all lower (P<0.05) in poor semen quality stallions than in normal stallions.
The BACs and primers developed in this study will facilitate future investigations of GR and LHR gene structure in the horse as well as providing a resource for physiological investigation of these two genes that are primary regulators of stress responsiveness and fertility. These data add important endocrine genes to the horse cytogenetic map. Also, important hormonal and gene expression changes have been identified in poor semen quality stallions for further investigation.
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Klimecki, Walter Thomas. "P-glycoprotein: Expression and function in normal circulating leukocytes." Diss., The University of Arizona, 1994. http://hdl.handle.net/10150/186715.
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P-glycoprotein (P-gly) is a well characterized membrane protein, expressed in cancer cells, functioning as an efflux pump. This function confers drug-resistance. P-gly is also expressed in normal tissues such as the liver and kidney. In normal tissues P-gly has restricted expression. In the kidney P-gly is expressed in tubular brush border. This suggests a physiologic role for P-gly. A goal of this work was to determine whether P-gly, if present in leukocytes, followed the cell-type restriction seen in other P-gly positive normal tissues. Assays measuring P-gly included immunofluorescence, immunocytochemistry, and immunoblot analysis. Northern blot analysis and RT-PCR were used to measure mdr1 mRNA. P-gly function was assayed by measuring the verapamil-sensitive retention of rhodamine 123 (rh123). Immunofluorescent staining of leukocytes for lineage and P-gly revealed high levels of P-gly in CD56+ cells. CD8+ cells followed in staining, with CD4+ and CD19+ cells at intermediate levels, and CD14+ and CD15+ cells staining at background. RNA analysis by RT-PCR confirmed the immunofluorescence data, except for CD15+ cells, which demonstrated mdr1 mRNA similar to CD4+ cells. Function assays confirmed the immunofluorescence results, with efficient clearing of dye from CD56+ cells, followed by CD8+, CD4+, and CD19+ cells. CD14+ and CD15+ cells did not demonstrate P-gly function. Immunoblot analysis of membranes and immunocytochemical analysis of CD15+ cells demonstrated P-gly. The high level of functional P-gly observed in CD56+ cells prompted experiments to determine whether P-gly was involved in the CD56+ mediated cytolytic response. Using 4 inhibitors of P-gly mediated efflux, cyclosporine A, PSC 833, R-verapamil, and S-verapamil, NK cells were assayed for cytolytic function. Each compound demonstrated dose-response relationships in inhibiting NK-mediated cytolysis. Each compound also demonstrated a dose-response in inhibition of P-gly mediated efflux, although there was not an exact correlation between efflux inhibition and cytolysis inhibition. Nevertheless, the data in this study demonstrate a relatively high level of P-gly expression in CD56+ and CD8+ cells. In addition, the data support a role for P-gly in the cytolytic function of NK cells, although the point of P-gly involvement in the process of cytolysis remains to be defined.
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Achenbaugh, Whitney Rachel. "Velopharyngeal function with varying articulatory rate in normal children." Thesis, University of Iowa, 2012. https://ir.uiowa.edu/etd/2806.
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The purpose of this study was to investigate the effect of variation of speaking rate, gender and age on aerodynamic and acoustic measure of the VP function in 19 typically-developing young children aged 4-7 years. Additionally, this study aimed to compare results from children from this study to that of Gauster, Yunusova and Zajac (2010). Aerodynamic measurements such as oral pressure, nasal pressure, nasal flow, and VP area were taken at the /m/ and /p/ segments in the word "hamper" (HAMPER) and the initial /p/ of "puppy" in the utterance "Buy Bobby a puppy" (BBP). Nasalance and nasalance distance was collected for the utterances "Buy Bobby a puppy" and "Mama made lemon jam" (MMJ). Speech tasks were performed in 4 different self-regulated rates including normal, fast, slow, and slowest. Results indicated that only the aerodynamic measures in the /m/ of HAMPER were affected by speaking rate. Rate affected the nasalance measures of BBP and MMJ and nasalance distance. Gender affected the nasalance of BBP, and age affected nasalance distance. Additionally, children varied from the adults in Gauster et al. (2010) in differences in rate, gender and variability. In summary, rate, gender, and age group had various effects on the measures relating to VP function in healthy children, and should therefore be considered when working with children with VP dysfunction.
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Loots, Mattheus Theodor. "The development of the quaternion normal distribution." Diss., University of Pretoria, 2010. http://hdl.handle.net/2263/25903.
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In this dissertation an overview on the real representation of quaternions in distribution theory is given. The density functions of the p-variate and matrix-variate quaternion normal distributions are derived from first principles, while that of the quaternion Wishart distribution is derived from the real associated Wishart distribution via the characteristic function. Applications of this theory in hypothesis testing is presented, and the density function of Wilks's statistic is derived for quaternion Wishart matrices.Dissertation (MSc)--University of Pretoria, 2011.
Statistics
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Tanaka, Y., Y. Tanuma, and A. A. Golubov. "Odd-frequency pairing in normal-metal/superconductor junctions." American Physical Society, 2007. http://hdl.handle.net/2237/11289.
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Elfgren, Christina I. "Aspects of frontal and medial temporal brain functions neuropsychological and functional imaging studies in normals and in frontotemporal dementia /." Lund : Dept. of Psychology, University of Lund, and Dept. of Psychogeriatrics, University Hospital, 1997. http://books.google.com/books?id=EuZqAAAAMAAJ.
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