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Dissertations / Theses on the topic 'Nonsteroidal anti-inflammatory agents'

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Published: 4 June 2021

Last updated: 25 July 2025

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1

Johns, Gianmarc Grazioli. "Structural requirements for time-dependent and time-independent inhibition of prostaglandin synthase I (COX-1) /." Click here for download, 2007. http://proquest.umi.com/pqdweb?did=1303296611&sid=1&Fmt=2&clientId=3260&RQT=309&VName=PQD.

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2

Sasane, Rahul Madhukar. "Assessment of the effectiveness of a non-steroidal anti-inflammatory drug (NSAID) algorithm in an integrated healthcare system /." Digital version accessible at:, 1998. http://wwwlib.umi.com/cr/utexas/main.

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3

Tettey-Amlalo, Ralph Nii Okai. "Application of dermal microdialysis and tape stripping methods to determine the bioavailability and/or bioequivalence of topical ketoprofen formulations." Thesis, Rhodes University, 2008. http://hdl.handle.net/10962/d1003274.

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The widespread acceptance of topical formulations intended for local and/or regional activity has prompted renewed interest in developing a model to determine the bioavailability of drugs in order to establish bioequivalence as a means of evaluating formulation performance of multisource products and also for use during formulation development. Current in vivo techniques such as blister suction and skin biopsy amongst others used to determine the bioavailability and/or bioequivalence of topical formulations are either too invasive to generate appropriate concentration-time profiles or require

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4

Zhu, Genghui. "Nonsteroidal antiinflammatory drugs and apoptosis of human gastric epithelial cells /." Hong Kong : University of Hong Kong, 1998. http://sunzi.lib.hku.hk/hkuto/record.jsp?B20471361.

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5

Chak, Man-lee Charlotta. "A retrospective study on the effectiveness of anti-ulcer drugs in the prevention of nonsteroidal inflammatory drugs (NSAID)-induced gastrointestinal effects." Click to view the E-thesis via HKUTO, 2004. http://sunzi.lib.hku.hk/hkuto/record/B31971453.

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6

Butler, Gregory James. "Non-steroidal anti-inflammatory drugs and skin cancer /." [St. Lucia, Qld.], 2005. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe19122.pdf.

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7

朱耿慧 and Genghui Zhu. "Nonsteroidal antiinflammatory drugs and apoptosis of human gastric epithelial cells." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1998. http://hub.hku.hk/bib/B31239845.

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8

Momani, Aiman A. "Assessment of the impact of the West Virginia Medicaid's prior authorization policy for NSAIDs on chronic patients economic and humanistic outcomes /." Morgantown, W. Va. : [West Virginia University Libraries], 1999. http://etd.wvu.edu/templates/showETD.cfm?recnum=847.

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Thesis (Ph. D.)--West Virginia University, 1999.<br>Title from document title page. Document formatted into pages; contains xii, 150 p. : ill. Includes abstract. Includes bibliographical references (p. 124-128).

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9

Griesbach, Robert Christian. "Approaches to the asymmetric synthesis of non-steroidal anti-inflammatory drugs /." Title page, table of contents and abstract only, 1996. http://web4.library.adelaide.edu.au/theses/09PH/09phg848.pdf.

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10

Bandara, Bandarage Mahesh Kithsiri Optometry &amp Vision Science Faculty of Science UNSW. "Investigation and characterisation of antibacterial properties of non-steroidal anti-inflammatory drugs." Awarded by:University of New South Wales. School of Optometry and Vision Science, 2005. http://handle.unsw.edu.au/1959.4/22284.

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Microbial contamination of contact lenses is a significant risk factor leading to adverse responses. Adhesion of microorganisms to a contact lens is the first step in a series of events that leads to contact lens-related infections or inflammation. Recently, some of the non-steroidal anti-inflammatory drugs (NSAIDs) have been shown to have the ability to interfere with microbial biofilm formation. In this project, antibacterial properties of commonly used NSAIDs (salicylic acid, sodium diclofenac and ketorolac) were assessed and characterised using biological assays and molecular biological te

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11

Gu, Qing. "Helicobacter pylori and non-steroidal anti-inflammatory drugs in gastric carcinogenesis." Click to view the E-thesis via HKUTO, 2006. http://sunzi.lib.hku.hk/hkuto/record/B36589718.

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12

Ford, Lora Beth. "The effectiveness of valdecoxib on post-endodontic pain." Morgantown, W. Va. : [West Virginia University Libraries], 2005. https://etd.wvu.edu/etd/controller.jsp?moduleName=documentdata&jsp%5FetdId=4032.

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Thesis (M.S.)--West Virginia University, 2005.<br>Title from document title page. Document formatted into pages; contains viii, 59 p. : ill. (some col.). Vita. Includes abstract. Includes bibliographical references (p. 33-38).

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13

Gu, Qing, and 谷青. "Helicobacter pylori and non-steroidal anti-inflammatory drugs in gastric carcinogenesis." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2006. http://hub.hku.hk/bib/B36589718.

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14

Chak, Man-lee Charlotta, and 翟敏莉. "A retrospective study on the effectiveness of anti-ulcer drugs in the prevention of nonsteroidal inflammatory drugs (NSAID)-inducedgastrointestinal effects." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2004. http://hub.hku.hk/bib/B31971453.

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15

Mantzaris, Debbie 1974. "Investigation of the mechanisms involved in delayed ulcer healing by nonsteroidal anti-inflammatory drugs (NSAIDs)." Monash University, Dept. of Surgery, 2001. http://arrow.monash.edu.au/hdl/1959.1/8095.

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16

Wong, Chun-yu Benjamin. "Role of Helicobacter pylori and non-steroidal anti-inflammatory drugs in prevention of gastric cancer." Click to view the E-thesis via HKUTO, 2005. http://sunzi.lib.hku.hk/hkuto/record/B31685493.

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17

Van, Leeuwen Milco. "Synthetic approaches to nonsteroidal anti-inflammatory agents via the ferrous ion initiated Sâ†Râ†N1-reaction." Thesis, University of East Anglia, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.305068.

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18

Bhandari, Khageshor Venables Barney J. "NSAID effect on prostanoids in fishes prostaglandin E2 levels in bluntnose minnows (Pimephales notatus) exposed to ibuprofen /." [Denton, Tex.] : University of North Texas, 2009. http://digital.library.unt.edu/permalink/meta-dc-11058.

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19

Diaz-Cruz, Edgar S. "Interrelationships between aromatase and cyclooxygenase-2 and their role in the autocrine and paracrine mechanisms in breast cancer." Connect to resource, 2005. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1117117648.

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20

Su, Tao, and 苏涛. "Time-resolved spectroscopic studies of photo-defluorination and photo-decarboxylation reactions of selected fluoroquinolone antibiotic and nonsteroidal anti-inflammatory drugs." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hdl.handle.net/10722/195990.

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This thesis aimed to investigate the features and properties of the ground states, transient species and photoproducts involved in the photophysical and photochemical processes for four kinds of drug compounds: lomefloxacin (LF), norfloxacin (NF), tiaprofenic acid (TPA), and flurbiprofen (Fp). The investigation used femtosecond transient absorption (fs-TA), nanosecond transient absorption (ns-TA), UV/Vis absorption spectra (UV/Vis), nanosecond transient resonance Raman (ns-TR2) and nanosecond time-resolved resonance Raman spectroscopy (ns-TR3), as well as density functional theory (DFT) calcul

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21

Moore, Stephen H. "The effectiveness of rofecoxib on post-endodontic pain." Morgantown, W. Va. : [West Virginia University Libraries], 2002. http://etd.wvu.edu/templates/showETD.cfm?recnum=2308.

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Thesis (M.S.)--West Virginia University, 2002.<br>Title from document title page. Document formatted into pages; contains viii, 51 p. : ill. Includes abstract. Includes bibliographical references (p. 39-42).

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22

Wong, Chun-yu Benjamin, and 王振宇. "Role of Helicobacter pylori and non-steroidal anti-inflammatory drugs in prevention of gastric cancer." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2005. http://hub.hku.hk/bib/B31685493.

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23

Lai, Kam-chuen. "Management of peptic ulcer bleeding the significance of Helicobacter pylori and non-steroidal anti-inflammatory drugs /." Click to view the E-thesis via HKUTO, 2005. http://sunzi.lib.hku.hk/hkuto/record/B31997156.

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24

Davis, Brian Robert. "Non-Steroidal Anti-Inflammatory Drug Use in Collegiate Athletes." PDXScholar, 2015. https://pdxscholar.library.pdx.edu/open_access_etds/2477.

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Non-steroidal anti-inflammatory drugs (NSAID) are a class of medications used in the treatment of pain, inflammation, and illness. These medications are common, affordable, and easy to access. For these reasons, NSAIDs are commonly used by athletes of all backgrounds for treating injuries and as ergogenic aids. However, despite these behaviors, NSAIDs have well-documented side effects and the efficacious nature of these medications has been brought into question. Despite this, many athletes continue to use these medications frequently and indiscriminately. It is not known why athletes use thes

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25

Lai, Kam-chuen, and 黎錦泉. "Management of peptic ulcer bleeding: the significance of Helicobacter pylori and non-steroidal anti-inflammatory drugs." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2005. http://hub.hku.hk/bib/B31997156.

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26

Barrios-Rodiles, Miriam. "Regulation of cyclooxygenase-2 expression in human macrophages." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape4/PQDD_0033/NQ64507.pdf.

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27

Hayball, Peter John. "Chirality in clinical pharmacology : studies with ketoprofen /." Title page, contents and abstract only, 1993. http://web4.library.adelaide.edu.au/theses/09PH/09phh413.pdf.

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Thesis (Ph. D.)--University of Adelaide, Dept. of Clinical and Experimental Pharmacology, 1993?<br>Copies of author's previously published articles in back-cover pocket. Includes bibliographical references (leaves 180-205).

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28

Chuang, Yung-ping, and 莊蓉萍. "Time-resolved resonance raman and density functional theory studies ofthe photochemistry of (S)-ketoprofen." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2008. http://hub.hku.hk/bib/B40988156.

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29

Chuang, Yung-ping. "Time-resolved resonance raman and density functional theory studies of the photochemistry of (S)-ketoprofen." Click to view the E-thesis via HKUTO, 2008. http://sunzi.lib.hku.hk/hkuto/record/B40988156.

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30

Dairam, Amichand. "An investigation into the neuroprotective properties of the non-steroidal anti-inflammatory agents tolmetin, sulindac and turmeric." Thesis, Rhodes University, 2006. http://hdl.handle.net/10962/d1003230.

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Accumulating evidence suggests that anti-inflammatory agents and antioxidants have neuroprotective properties and may be beneficial in the treatment of neurodegenerative disorders. In the present study, the possible neuroprotective properties of tolmetin, sulindac and turmeric were investigated. The antioxidant effects of tolmetin and sulindac were determined by inducing free radical generation with quinolinic acid (QA), cyanide or iron (II) in rat brain homogenates or primary hippocampal neurons. Tolmetin and sulindac significantly reduce lipid peroxidation and scavenge the superoxide anion.

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31

Chew, Angela Christine. "The anti-proliferative effects of thiazolidinediones and non-steriodal anti-inflammatory drugs on androgen-independent prostate cancer." University of Western Australia. School of Medicine and Pharmacology, 2009. http://theses.library.uwa.edu.au/adt-WU2009.0200.

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[Truncated abstract] In recent years a better understanding of the biology of PPAR , a nuclear transcription factor, has emerged, leading to a resurgence in targeting PPAR for chemotherapy. The family of synthetic PPAR agonists, the thiazolidinediones (TZDs), and non-steroidal anti-inflammatory drugs (NSAIDs) have been implicated in the inhibition of cell proliferation, apoptosis and cell cycle arrest of androgen-sensitive (LNCaP) and androgen-independent (PC-3 and DU145) prostate cancer cells generating much interest in their use for potential curative cancer therapies. In light of the pote

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32

Menke, Eric R. "The effectiveness of prophylactic etodolac on post-endodontic pain." Morgantown, W. Va. : [West Virginia University Libraries], 1999. http://etd.wvu.edu/templates/showETD.cfm?recnum=484.

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Thesis (M.S.)--West Virginia University, 1999.<br>Title from document title page. Document formatted into pages; contains vii, 62 p. : ill. Vita. Includes abstract. Includes bibliographical references (p. 41-44).

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33

Basson, Erina. "Effect of ultrasound on transdermal permeation of diclofenac and the temperature effects on human skin." Thesis, Stellenbosch : University of Stellenbosch, 2005. http://hdl.handle.net/10019.1/2166.

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Thesis (MScMed (Pharmacology))--University of Stellenbosch, 2005.<br>During the last two decades the effects of ultrasound on the transdermal diffusion of a wide variety of drugs have been extensively investigated. Because there is much uncertainty regarding the efficacy of and mechanisms involved in this mode of permeation enhancement, the objective of the study was to investigate the effect of ultrasound on the transdermal permeation of the nonsteroidal anti-inflammatory drug, diclofenac. For this purpose a dual-stage experimental design and a continuous flow-through diffusion system was use

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34

Öztürk, Özlem Altuntaş İrfan. "Yaşlı ratlarda selektif ve non selektif cox inhibitörlerinin NMDA reseptör subunitlerine etkisi /." Isparta: SDÜ Tıp Fakültesi, 2006. http://tez.sdu.edu.tr/Tezler/TT00268.pdf.

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35

Parra, Coca Alexander. "Nanopartículas de carprofen para diferentes vías de administración." Doctoral thesis, Universitat de Barcelona, 2016. http://hdl.handle.net/10803/396655.

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El carprofen (CP), es un antiinflamatorio no esteroideo, con actividad antiinflamatoria, analgésica y antipirética, se utiliza en medicina veterinaria para el tratamiento de patologías de origen agudo y crónico, como osteoarticulares, musculares, osteomusculares, respiratorias y también a nivel perioperatorio. Actualmente la nanotecnología es aplicada cada vez más en todos los campos de la investigación. Las nanopartículas (NPs) a nivel farmacéutico hacen parte de un gran componente para la encapsulación de fármacos, dentro de estas están las NPs poliméricas que presentan una gran versatili

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36

Faith, Seth Adam. "Resveratrol (3,5,4' trihydroxy-trans-stilbene) blocks herpes simplex virus replication by affecting a host factor." [Kent, Ohio] : Kent State University, 2006. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=kent1162304949.

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Thesis (Ph.D.)--Kent State University, 2006.<br>Title from PDF t.p. (viewed Mar. 11, 2009). Advisor: John J. Docherty. Keywords: herpes simplex, virus, resveratrol, NF-kappaB, NSAID Includes bibliographical references (p. 100-105).

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37

Bhandari, Khageshor. "NSAID effect on prostanoids in fishes: Prostaglandin E2 levels in bluntnose minnows (Pimephales notatus) exposed to ibuprofen." Thesis, University of North Texas, 2009. https://digital.library.unt.edu/ark:/67531/metadc11058/.

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Prostanoids are oxygenated derivatives of arachidonic acid with a wide range of physiological effects in vertebrates including modulation of inflammation and innate immune responses. Nonsteroidal anti-inflammatory drugs (NSAIDs) act through inhibition of cyclooxygenase (COX) conversion of arachidonic acid to prostanoids. In order to better understand the potential of environmental NSAIDS for interruption of normal levels COX products in fishes, we developed an LC/MS/MS-based approach for tissue analysis of 7 prostanoids. Initial studies examining muscle, gut and gill demonstrated that prostag

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38

Machado, de Carvalho Liliana Sofia. "Study of the expression and regulation of the autocrine loop components of the cyclooxygenase pathway and their implication in aspirin exacerbated respiratory disease." Doctoral thesis, Universitat de Barcelona, 2015. http://hdl.handle.net/10803/396213.

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Aspirin exacerbated respiratory disease (AERD) is a clinical syndrome characterized by the combination of nasal polyps (NPs), chronic hypertrophic eosinophilic sinusitis, asthma and severity to any medication that inhibits cyclooxygenase (COX)-1 enzymes, namely aspirin and other non-steroidal anti-inflammatory drugs. AERD is characterized by intense inflammation of the respiratory mucosa, with large number of activated tissue eosinophils, mast cells, monocytes, and neutrophils. The persistent inflammation likely contributes to the recurrent development of severe nasal polyposis. The pathoge

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39

Tettey-Amlalo, Ralph Nii Okai. "In vitro release of ketoprofen from proprietary and extemporaneously manufactured gels." Thesis, Rhodes University, 2005. http://eprints.ru.ac.za/295/.

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40

Bhala, Neeraj. "Coxibs and traditional NSAIDs : systematic overviews of the randomised evidence for the effects of traditional non-steroidal anti-inflammatory drugs and selective inhibitors of cyclo-oxygenase-2 on vascular and upper gastrointestinal outcomes." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:2b6d8279-bce1-44bd-84c5-7658723786b2.

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<b>Background:</b> Comparative assessments of the vascular and upper gastrointestinal risks of different regimens of non-steroidal anti-inflammatory drugs (NSAIDs) are required. <b>Methods:</b> Meta-analyses were conducted, using individual participant data where possible, of placebo-controlled trials of a selective cyclo-oxygenase [COX]-2 inhibitor ('coxib') or traditional NSAID, or randomised trials of a coxib versus traditional NSAIDs. A prespecified subdivision of traditional NSAID regimens of those with antiplatelet activity (mainly naproxen) and those without (mainly diclofenac) was made

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41

Midroni, Ran. "The effect acetylsalicylic acid and acetaminophen on edema, adrenocorticotropin, and beta-endorphin during orofacial inflammation." 1996. http://catalog.hathitrust.org/api/volumes/oclc/47030234.html.

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42

Jack, DS. "Characterization of the protein binding of non-steroidal anti-inflammatory drugs in synovial fluid." Thesis, 1990. https://eprints.utas.edu.au/20167/7/whole_JackDamonScott1990.pdf.

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The clinical pharmacokinetic properties of NSAID's are markedly influenced by the affinity and extent of their protein binding properties in plasma and synovial fluid. Whilst the total level of NSAID is dependent upon concentration and affinity of local protein, it is the unbound / free fraction that is the species which readily diffuses between plasma and synovial fluid. The synovial fluid kinetics of the NSAlD's have received remarkably little attention until recent years, despite the increasing accumulation of evidence casting doubt on a consistent pharmacokinetic correlation between

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43

Jack, Damon Scott. "The pharmacokinetics of chiral non-steroidal anti-inflammatory drugs in synovial fluid and plasma." Thesis, 1993. https://eprints.utas.edu.au/20279/1/whole_JackDamonScott1994_thesis.pdf.

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This research described the pharmacokinetics of free/unbound and total (bound plus unbound) enantiomers of two commonly prescribed non-steroidal anti-inflammatory drugs (NSAIDs: ketoprofen and ibuprofen) in the synovial fluid and plasma of patients with inflammatory and non-inflammatory joint disease. This was facilitated by the development of enantiomeric assays of sufficient sensitivity to enable the measurement of the very low levels of non-protein bound drug commonly encountered in plasma, and synovial fluid. The assays involved formation of a mixed anhydride of the drug with ethylc

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44

Bichara, Jean Bashir. "Regenerative therapy for osseous defects with and without NSAIDS." 1997. http://catalog.hathitrust.org/api/volumes/oclc/48208831.html.

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45

Griesbach, Robert Christian. "Approaches to the asymmetric synthesis of non-steroidal anti-inflammatory drugs / by Robert Christian Griesbach." Thesis, 1996. http://hdl.handle.net/2440/18855.

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Bibliography: leaves 159-164.<br>iv, 158 leaves ; 30cm.<br>This thesis examines routes for the asymmetric synthesis of three members of the nonsteroidal anti-inflammatory class of drugs (NSAIDs) The aryl propanoic acid ibuprofen is synthesized in 96% e.e. Control of stereochemistry is achieved by use of the Sharpless epoxidation reaction, followed by reduction of the product epoxide by complex hydride with assistance by titanium tetraisopropoxide acting as a Lewis acid. The final step is the coupling of an optically active carboxylic acid intermediate with the iso-butyl side chain to give (S)-

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46

Motsko, Stephen Paul Rascati Karen L. "The relationship between Cox-2 inhibitors and cardiovascular risk a retrospective analysis using the Veteran Affairs (VA) database /." 2005. http://repositories.lib.utexas.edu/bitstream/handle/2152/1637/motskos88886.pdf.

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47

Holt, Kris Edward. "Bioequivalence studies of ketoprofen : product formulation, pharmacokinetics, deconvolution, and in vitro - in vivo correlations." Thesis, 1997. http://hdl.handle.net/1957/33829.

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This thesis describes a project to produce controlled release ketoprofen beads for capsules, both at Oregon State University and in an industrial scale-up operation, that are bioequivalent to the commercial product Oruvail. A bead formulation was produced by layering drug and binders in water onto nonpareil sugar seeds in a spray coating apparatus. Ketoprofen beads manufactured in this manner will immediately release their drug content in either an in vitro or an in vivo environment. Industrially produced beads were non-homogeneous in size. Large beads in a coating batch sweep up a disproporti

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48

Kitching, Jacki Anne. "The development of new, non-steroidal anti-asthma drugs with novel modes of action." Phd thesis, 2008. http://hdl.handle.net/1885/151679.

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49

Olazabal-Bello, Angelita C. "The effect of prophylactic use of oral ketorolac and ibuprofen in the control of endodontic post treatment pain a thesis submitted in partial fulfillment ... for the degree of Master of Science in Endodontics ... /." 1993. http://catalog.hathitrust.org/api/volumes/oclc/68944152.html.

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50

Motsko, Stephen Paul. "The relationship between Cox-2 inhibitors and cardiovascular risk: a retrospective analysis using the Veteran Affairs (VA) database." Thesis, 2005. http://hdl.handle.net/2152/1637.

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