Relevant bibliographies by topics / Nonsteroidal anti-inflammatory agents Physiological effect

Academic literature on the topic 'Nonsteroidal anti-inflammatory agents Physiological effect'

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Published: 10 December 2022
Last updated: 29 January 2023

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Journal articles on the topic "Nonsteroidal anti-inflammatory agents Physiological effect"

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Mason, HH. "Morphine sulfate, transdermal fentanyl citrate and ketorolac tromethamine: effects on postoperative pulmonary function." American Journal of Critical Care 2, no. 1 (January 1, 1993): 61–64. http://dx.doi.org/10.4037/ajcc1993.2.1.61.

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The physiological effects of morphine sulfate and fentanyl citrate on postoperative pulmonary function demonstrate varying degrees of respiratory depression related to dose, route of administration and pre-existing pathologies. Current postoperative analgesic therapies that include concomitant use of narcotic agonists and nonsteroidal anti-inflammatory drugs require adjustment of drug dosages to provide adequate pain relief while avoiding drug-induced complications. Specific nursing considerations include understanding therapeutic and adverse effects of these agents on pain and ventilation, continuous pain assessment and early recognition and treatment of respiratory depression.
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Alem, Mohammed A. S., and L. Julia Douglas. "Effects of Aspirin and Other Nonsteroidal Anti-Inflammatory Drugs on Biofilms and Planktonic Cells of Candida albicans." Antimicrobial Agents and Chemotherapy 48, no. 1 (January 2004): 41–47. http://dx.doi.org/10.1128/aac.48.1.41-47.2004.

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ABSTRACT Prostaglandins are now known to be produced by Candida albicans and may play an important role in fungal colonization. Their synthesis in mammalian cells is decreased by inhibitors of the cyclooxygenase isoenzymes required for prostaglandin formation. In the present study, a catheter disk model system was used to investigate the effects of nonsteroidal anti-inflammatory drugs (all cyclooxygenase inhibitors) on biofilm formation by three strains of C. albicans. Seven of nine drugs tested at a concentration of 1 mM inhibited biofilm formation. Aspirin, etodolac, and diclofenac produced the greatest effects, with aspirin causing up to 95% inhibition. Celecoxib, nimesulide, ibuprofen, and meloxicam also inhibited biofilm formation, but to a lesser extent. Aspirin was active against growing and fully mature (48-h) biofilms; its effect was dose related, and it produced significant inhibition (20 to 80%) at pharmacological concentrations. Simultaneous addition of prostaglandin E2 abolished the inhibitory effect of 25 or 50 μM aspirin. At 1 mM, aspirin reduced the viability of biofilm organisms to 1.9% of that of controls. Surviving cells had a wrinkled appearance, as judged by scanning electron microscopy, and consisted of both yeasts and hyphae. Treatment with other cyclooxygenase inhibitors, such as etodolac, resulted in biofilms that consisted almost entirely of yeast cells. In conventional assays for germ tube formation, these drugs produced significant inhibition, whereas aspirin had little effect. Our findings suggest that cyclooxygenase-dependent synthesis of fungal prostaglandin(s) is important for both biofilm development and morphogenesis in C. albicans and may act as a regulator in these physiological processes. Our results also demonstrate that aspirin possesses potent antibiofilm activity in vitro and could be useful in combined therapy with conventional antifungal agents in the management of some biofilm-associated Candida infections.
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Rizaldy Pinzon. "Closing the Gap of Unmet Needs in Inflammatory Pain Management: Case Series of Predimenol for Pain." MEDICINUS 34, no. 2 (August 1, 2021): 29–33. http://dx.doi.org/10.56951/medicinus.v34i2.65.

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Chronic inflammatory pain is major medical problem worldwide. Nonsteroidal anti-inflammatory drugs (NSAIDs) and selective cyclooxygenase (COX)-2 inhibitors are commonly used medications to treat chronic pain. However, these agents have been associated with serious gastrointestinal, renal and cardiovascular adverse effects. This limitation indicates a clear unmet need in terms of safety of current treatment options for the management of chronic inflammatory pain. Those adverse effects may caused by overlapping roles of COX-1 and COX-2 in physiological and pathophysiological processes. Predimenol is a herbal medicine that can be used to treat pain. Recent findings showed that these phytochemicals may directly act upon several inflammatory processes and offer compelling evidence that predimenol could reduce pain and inflammation. We report two cases and short review of the use of predimenol for pain management. Our review showed that predimenol formulations could be a valuable alternative treatment to relieve symptoms of pain with good safety profile. Further researches through large, high quality RCTs to investigate the clinical benefit of predimenol for pain management are needed.
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Chan, Melissa V., and John L. Wallace. "Hydrogen sulfide-based therapeutics and gastrointestinal diseases: translating physiology to treatments." American Journal of Physiology-Gastrointestinal and Liver Physiology 305, no. 7 (October 1, 2013): G467—G473. http://dx.doi.org/10.1152/ajpgi.00169.2013.

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Hydrogen sulfide (H2S) is a gaseous meditator that has various physiological and pathophysiological roles in the body. It has been shown to be an important mediator of gastrointestinal (GI) mucosal defense and contributes significantly to repair of damage and resolution of inflammation. Synthesis of H2S increases markedly after mucosal injury, and inhibition of H2S in such circumstances leads to delayed healing and exacerbated inflammation. The beneficial effects of H2S may be attributable to its ability to elevate mucosal blood flow, prevent leukocyte-endothelial adhesion, reduce oxidative stress, and stimulate angiogenesis. The use of H2S-donating agents and inhibitors of the key enzymes contributing to H2S synthesis have provided strong evidence for the importance of H2S in enhancing mucosal resistance to damage, as well as modulating inflammation and repair. In recent years, significant evidence has been generated to support the notion that these positive aspects of H2S can be exploited in drug design, particularly for arthritis, inflammatory bowel disease, and colon cancer chemoprevention. Thus novel H2S-based therapies have been shown to be effective anti-inflammatories that can promote the resolution of inflammation and accelerate the healing of GI ulcers. Encouraging results have already been seen experimentally with a mesalamine derivative and with H2S-releasing derivatives of nonsteroidal anti-inflammatory drugs.
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Chan, A., and V. Ramachandra. "Comparing the analgesic effect of nonsteroidal anti-inflammatory agents." Anaesthesia 48, no. 12 (February 22, 2007): 1117. http://dx.doi.org/10.1111/j.1365-2044.1993.tb07569.x.

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Pegg, Anthony E. "Spermidine/spermine-N1-acetyltransferase: a key metabolic regulator." American Journal of Physiology-Endocrinology and Metabolism 294, no. 6 (June 2008): E995—E1010. http://dx.doi.org/10.1152/ajpendo.90217.2008.

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Spermidine/spermine- N1-acetyltransferase (SSAT) regulates cellular polyamine content. Its acetylated products are either excreted from the cell or oxidized by acetylpolyamine oxidase. Since polyamines play critical roles in normal and neoplastic growth and in ion channel regulation, SSAT is a key enzyme in these processes. SSAT is very highly regulated. Its content is adjusted in response to alterations in polyamine content to maintain polyamine homeostasis. Certain polyamine analogs can mimic the induction of SSAT and cause a loss of normal polyamines. This may have utility in cancer chemotherapy. SSAT activity is also induced via a variety of other stimuli, including toxins, hormones, cytokines, nonsteroidal anti-inflammatory agents, natural products, and stress pathways, and by ischemia-reperfusion injury. These increases are initiated by alterations in Sat1 gene transcription reinforced by alterations at the other regulatory steps, including protein turnover, mRNA processing, and translation. Transgenic manipulation of SSAT activity has revealed that SSAT activity links polyamine metabolism to lipid and carbohydrate metabolism by means of alterations in the content of acetyl-CoA and ATP. A high level of SSAT stimulates flux through the polyamine biosynthetic pathway, since biosynthetic enzymes are induced in response to the fall in polyamines. This sets up a futile cycle in which ATP is used to generate S-adenosylmethionine for polyamine biosynthesis and acetyl-CoA is consumed in the acetylation reaction. A variety of other effects of increased SSAT activity include death of pancreatic cells, blockage of regenerative tissue growth, behavioral changes, keratosis follicularis spinulosa decalvans, and hair loss. These are very likely due to changes in polyamine and putrescine levels, although increased oxidative stress via the oxidation of acetylated polyamines may also contribute. Recently, it was found that the SSAT protein and/or a related protein, thialysine acetyltransferase, interacts with a number of other important proteins, including the hypoxia-inducible factor-1 α-subunit, the p65 subunit of NF-κB, and α9β1-integrin, altering the function of these proteins. It is not yet clear whether this functional alteration involves protein acetylation, local polyamine concentration changes, or other effects. It has been suggested that SSAT may also be a useful target in diseases other than cancer, but the wide-ranging physiological and pathophysiological effects of altered SSAT expression will require very careful limitation of such strategies to the relevant cells to avoid toxic effects.
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Thaller, John, Matthew Walker, Alex J Kline, and D. Greg Anderson. "The Effect of Nonsteroidal Anti-Inflammatory Agents on Spinal Fusion." Orthopedics 28, no. 3 (March 1, 2005): 299–303. http://dx.doi.org/10.3928/0147-7447-20050301-15.

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Hanson, Curtis A., Paul S. Weinhold, Hessam M. Afshari, and Laurence E. Dahners. "The Effect of Analgesic Agents on the Healing Rat Medial Collateral Ligament." American Journal of Sports Medicine 33, no. 5 (May 2005): 674–79. http://dx.doi.org/10.1177/0363546504269722.

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Background Studies have suggested that some nonselective nonsteroidal anti-inflammatory drugs, including piroxicam, may improve ligament healing, whereas other nonsteroidal anti-inflammatory drugs, including ibuprofen and the cyclooxygenase-2 inhibitor celecoxib, may have no effect on the mechanical properties or may even deter the healing process. These results might reflect variations in cyclooxygenase enzyme selectivity by different drugs or, alternatively, may be related to their analgesic properties because it is generally accepted that early activity improves ligament healing. Hypothesis Nonselective nonsteroidal anti-inflammatory drugs improve ligament healing, whereas other analgesics provide lesser degrees of improvement, and cyclooxygenase-2 inhibitors are detrimental. Study Design Controlled laboratory study. Methods One hundred fifty-five Sprague-Dawley rats were divided into 7 treatment groups (piroxicam, naproxen, rofecoxib, butorphanol, 2 doses of acetaminophen, and control). The right medial collateral ligament of each rat was transected, and the drugs were administered postoperatively on days 1 to 6. On day 14, the rats were sacrificed, and mechanical testing was performed on the medial collateral ligament. Results The piroxicam group demonstrated significantly greater load to failure (27%) compared with the control. No significant differences were observed between other groups. Conclusions Piroxicam improves ligament healing, but this effect cannot be attributed to all nonselective nonsteroidal anti-inflammatory drugs. Opiate analgesics, acetaminophen, and cyclooxygenase-2 inhibitors do not appear to categorically affect ligament healing. Clinical Relevance In the treatment of ligament injury, piroxicam may be a drug of choice.
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Miranda, H. F., F. Sierralta, and G. Pinardi. "Carbachol interactions with nonsteroidal anti-inflammatory drugs." Canadian Journal of Physiology and Pharmacology 80, no. 12 (December 1, 2002): 1173–79. http://dx.doi.org/10.1139/y02-145.

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The inhibition of cyclooxygenase enzymes by nonsteroidal anti-inflammatory drugs (NSAIDs) does not completely explain the antinociceptive efficacy of these agents. It is known that cholinergic agonists are antinociceptive, and this study evaluates the interactions between carbachol and some NSAIDs. Antinociceptive activity was evaluated in mice by the acetic acid writhing test. Dose–response curves were constructed for NSAIDs and carbachol, administered either intraperitoneally (i.p.) or intrathecally (i.t.). The interactions of carbachol with NSAIDs were evaluated by isobolographic analysis after the simultaneous administration of fixed proportions of carbachol with each NSAID. All of the drugs were more potent after spinal than after systemic administration. The combinations of NSAIDs and carbachol administered i.p. were supra-additive; however, the i.t. combinations were only additive. Isobolographic analysis of the coadministration of NSAIDs and carbachol and the fact that atropine antagonized the synergistic effect suggest that carbachol may strongly modulate the antinociceptive activity of NSAIDs; thus, central cholinergic modulation would be an additional mechanism for the antinociceptive action of NSAIDs, unrelated to prostaglandin biosynthesis inhibition.Key words: antinociception, nonsteroidal anti-inflammatory drugs, cholinergic, carbachol, writhing test.
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Yücesoy, M., I. M. A. Öktem, and Z. Gülay. "In-VitroSynergistic Effect of Fluconazole with Nonsteroidal Anti-Inflammatory Agents AgainstCandida albicansStrains." Journal of Chemotherapy 12, no. 5 (January 2000): 385–89. http://dx.doi.org/10.1179/joc.2000.12.5.385.

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Dissertations / Theses on the topic "Nonsteroidal anti-inflammatory agents Physiological effect"

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Chak, Man-lee Charlotta, and 翟敏莉. "A retrospective study on the effectiveness of anti-ulcer drugs in the prevention of nonsteroidal inflammatory drugs (NSAID)-inducedgastrointestinal effects." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2004. http://hub.hku.hk/bib/B31971453.

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Bhandari, Khageshor Venables Barney J. "NSAID effect on prostanoids in fishes prostaglandin E2 levels in bluntnose minnows (Pimephales notatus) exposed to ibuprofen /." [Denton, Tex.] : University of North Texas, 2009. http://digital.library.unt.edu/permalink/meta-dc-11058.

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Shabani, Fariba. "Regulation of matrix metalloproteinases, their inhibitors and IL-8 in inflammatory rheumatic diseases : effects of cytokines and anti-rheumatic agents /." Title page and contents only, 1997. http://web4.library.adelaide.edu.au/theses/09PH/09phs524.pdf.

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Chuang, Yung-ping, and 莊蓉萍. "Time-resolved resonance raman and density functional theory studies ofthe photochemistry of (S)-ketoprofen." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2008. http://hub.hku.hk/bib/B40988156.

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Chuang, Yung-ping. "Time-resolved resonance raman and density functional theory studies of the photochemistry of (S)-ketoprofen." Click to view the E-thesis via HKUTO, 2008. http://sunzi.lib.hku.hk/hkuto/record/B40988156.

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6

Van, Eeden Simon Peter. "The effect of a topical combined anti-inflammatory antibiotic preparation on the outcome of third molar surgery." Diss., Pretoria : [s.n.], 2000. http://upetd.up.ac.za/thesis/available/etd-01052007-123151/.

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Basson, Erina. "Effect of ultrasound on transdermal permeation of diclofenac and the temperature effects on human skin." Thesis, Stellenbosch : University of Stellenbosch, 2005. http://hdl.handle.net/10019.1/2166.

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Thesis (MScMed (Pharmacology))--University of Stellenbosch, 2005.
During the last two decades the effects of ultrasound on the transdermal diffusion of a wide variety of drugs have been extensively investigated. Because there is much uncertainty regarding the efficacy of and mechanisms involved in this mode of permeation enhancement, the objective of the study was to investigate the effect of ultrasound on the transdermal permeation of the nonsteroidal anti-inflammatory drug, diclofenac. For this purpose a dual-stage experimental design and a continuous flow-through diffusion system was used. Therapeutic levels of continuous ultrasound of 3 MHz at an intensity of 2 W/cm2 for 10 min, were used. It was clear from the present study that ultrasound enhanced the permeability of human skin to diclofenac released from a commercially available gel. These results were in contrast with those obtained for ibuprofen in an in vitro study across human skin, but in agreement with those obtained in two in vivo studies of the latter nonsteroidal anti-inflammatory drug. Steady state flux values of diclofenac remained approximately 1.26 times higher than those of controls during the 24 h of the experiment. These observations concurred with those made in two previous in vivo studies. Furthermore, the in vitro flow-through diffusion model was shown to have predictive value as an in vivo method for sonophoresis. Temperature-dependent flux rates for 3H2O across human skin were also studied. The mechanistic effects of ultrasound on the permeability characteristics of human skin have been reported on in a number of studies. Although various mechanisms have been proposed, there is no consensus regarding their relative importance. In addition the temperature-dependent flux changes of 3H2O across human skin were investigated using a continuous flow-through diffusion system. The same ultrasound parameters as in the permeability experiments were used. The results obtained showed that temperature increases of approximately 10 °C occurred following sonication. The flux changes of 3H2O across human skin between 37 °C and 42 °C were shown to be reversible. The results from the present study do not support the sonication-heating theory in which permeability changes in skin are primarily attributed to thermally-induced changes in stratum corneum lipids. It was therefore concluded that the enhancement of diclofenac permeation by sonication could not be adequately explained primarily on a thermal basis.
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Garrett, Ian Ross. "Studies of the effect of metal containing drugs on acute and chronic inflammation /." Title page, table of contents and summary only, 1986. http://web4.library.adelaide.edu.au/theses/09PH/09phg2386.pdf.

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Bhandari, Khageshor. "NSAID effect on prostanoids in fishes: Prostaglandin E2 levels in bluntnose minnows (Pimephales notatus) exposed to ibuprofen." Thesis, University of North Texas, 2009. https://digital.library.unt.edu/ark:/67531/metadc11058/.

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Prostanoids are oxygenated derivatives of arachidonic acid with a wide range of physiological effects in vertebrates including modulation of inflammation and innate immune responses. Nonsteroidal anti-inflammatory drugs (NSAIDs) act through inhibition of cyclooxygenase (COX) conversion of arachidonic acid to prostanoids. In order to better understand the potential of environmental NSAIDS for interruption of normal levels COX products in fishes, we developed an LC/MS/MS-based approach for tissue analysis of 7 prostanoids. Initial studies examining muscle, gut and gill demonstrated that prostaglandin E2 (PGE2) was the most abundant of the measured prostanoids in all tissues and that gill tissue had the highest and most consistent concentrations of PGE2. After short-term 48-h laboratory exposures to concentrations of 5, 25, 50 and 100 ppb ibuprofen, 50.0ppb and 100.0 ppb exposure concentrations resulted in significant reduction of gill tissue PGE2 concentration by approximately 30% and 80% respectively. The lower exposures did not result in significant reductions when compared to unexposed controls. Measured tissue concentrations of ibuprofen indicated that this NSAID had little potential for bioaccumulation (BCF 1.3) and the IC50 of ibuprofen for inhibition of PGE2 production in gill tissue was calculated to be 0.4 µM. Short-term laboratory exposure to ibuprofen did not result in significant alteration of concentrations of PGE2 at environmentally relevant concentrations.
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Demasi, Maryanne. "The effects of hypoxia on cyclooxygenase-2 expression and eicosanoid synthesis /." Title page, table of contents and summary only, 2004. http://web4.library.adelaide.edu.au/theses/09PH/09phd3729.pdf.

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Thesis (Ph.D.)--University of Adelaide, Dept. of Medicine and Royal Adelaide Hospital, Rheumatology Unit, 2004.
Includes list of publications arising from this thesis. Erratum attached to inside back cover. "25/03/2004." Includes bibliographical references (leaves 185-257).
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Books on the topic "Nonsteroidal anti-inflammatory agents Physiological effect"

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Peter, Brooks, ed. Basis for variability of response to anti-rheumatic drugs: Proceedings of a satellite meeting of the Xth International Congress of Pharmacology, held in Sydney, Australia, August 20-22, 1987. Basel: Birkhäuser Verlag, 1988.

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Vane, John R. Improved non-steroid anti-flammatory drugs COX-2 enzyme inhibitors: Proceedings of a conference held on October 10-11, 1995, at Regent's College, London. Dordrecht: Kluwer Academic Publishers, 1996.

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Peter, Brooks, Day Richard, and Symposium on Non-steroidal Anti-inflammatory Drugs, Basis for Variability in response (1985 : Leura, N.S.W.), eds. Non-steroidal anti-inflammatory drugs, basis for variability in response: 16-18 May, 1985, at Leura, New South Wales, Australia. Basel: Birkhäuser, 1985.

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William Harvey Conference (1995 London, England). Improved non-steroid anti-inflammatory drugs: COX-2 enzyme inhibitors : proceedings of a conference held on October 10-11, 1995, at Regent's College, London. Dordrecht: Kluwer Academic, 1996.

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1941-, Rainsford K. D., and Powanda M. C, eds. Safety and efficacy of non-prescription (OTC) analgesics and NSAIDs: Proceedings of the international conference held at the South San Francisco Conference Center, San Francisco, CA, USA on Monday 17th March 1997. Dordrecht: Kluwer, 1998.

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Day and Brooks. The Proceedings of a Symposium on Non-steroidal Antiinflammatory Drugs - Basis for Variability in Response (Agents and Actions Supplements). Birkhauser, 1985.

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Peter, Brooks, Day Richard, and International Congress of Rheumatology, (16th : 1985 : Leura, N.S.W.), eds. Non-steroidal antiinflammatory drugs: Basis for variability in response. Basel: Birkhäuser, 1985.

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Effect of a non-steroidal, anti-inflammatory drug (Indocin) on selected parameters of muscular function following concentric and eccentric work. 1987.

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Effect of a non-steroidal, anti-inflammatory drug (Indocin) on selected parameters of muscular function following concentric and eccentric work. 1987.

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Effect of a non-steroidal, anti-inflammatory drug (Indocin) on selected parameters of muscular function following concentric and eccentric work. 1987.

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Book chapters on the topic "Nonsteroidal anti-inflammatory agents Physiological effect"

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Manchia, Mirko, Martina Pinna, and Eileen M. Denovan-Wright. "Effect of Interacting Nonsteroidal Anti-Inflammatory Agents (NSAIDs) and Opioids on Mood." In Neuropathology of Drug Addictions and Substance Misuse, 111–19. Elsevier, 2016. http://dx.doi.org/10.1016/b978-0-12-800634-4.00011-1.

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Clark, Matthew D. "Non-Opioid Analgesic Side Effects." In Pain, 111–20. Oxford University Press, 2022. http://dx.doi.org/10.1093/med/9780197542873.003.0014.

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The euphoric effects of opioids have been understood since the Mesopotamian period when spiritual leaders used opium to relieve grief, worry, and regret. Opioid use has risen since the nineteenth century, leading to the crisis known today as the “opioid epidemic.” This resulted in an increase in opioid-related morbidity and mortality. In the midst of this epidemic, healthcare providers can turn to non-opioid analgesics for non-malignant pain. Agents such as acetaminophen, nonsteroidal anti-inflammatory drugs (NSAIDs), antidepressants, anticonvulsants, muscle relaxants, and corticosteroids are useful for managing pain associated with headaches, osteoarthritis, neuropathy, and bone pain. Non-opioids have little to no risk for abuse and addiction. Although generally well tolerated, these agents can be associated with unfavorable adverse reactions that may lead to the discontinuation of the agent or even hospitalization. These adverse reactions can be avoided with proper understanding of the side-effect profiles, contraindications, warnings, and drug interactions of each analgesic. Acknowledging these safety considerations of non-opioid analgesics can optimize a patient’s quality of life.
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Christina Lustrup, Ditte, and Kaj Winther. "Rose Hip as a Nutraceutical." In Medicinal Plants [Working Title]. IntechOpen, 2022. http://dx.doi.org/10.5772/intechopen.105392.

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From ancient times, rose hip has been used as food source and as part of herbal remedies. Modern research has confirmed that rose hip, especially when containing seeds and shells, reduces pain and improves daily activity in animal models and in patients with osteoarthritis. The effect size on pain is comparable to that observed with nonsteroidal anti-inflammatory agents and superior to that obtained with paracetamol. For example, treatment with a subspecies of Rosa canina (Lito) resulted in 50% reduction in intake of pain killers. There are also strong indications that conditions such as rheumatoid arthritis, aging skin, and wrinkles benefit from treatment with rose hip. Cardiovascular diseases, especially where hyperlipidemia plays a major role, can be treated with rose hip, since a modest reduction of blood cholesterol levels as well as kidney and liver protection has been reported with the treatment. Variation in efficacy and amount of active ingredients in the different species, as well as with different ways of production, should be recognized. Rose hip can be collected from nature. It takes 5–7 Rosa canina berries to produce the daily dose of 5 gram of mixed shell-seed powder.
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