Log in

Relevant bibliographies by topics / Non transcriptional / Dissertations / Theses

To see the other types of publications on this topic, follow the link: Non transcriptional.

Dissertations / Theses on the topic 'Non transcriptional'

Author: Grafiati

Published: 9 March 2023

Last updated: 31 July 2025

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 dissertations / theses for your research on the topic 'Non transcriptional.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse dissertations / theses on a wide variety of disciplines and organise your bibliography correctly.

1

Mayhew, Michael. "Coding regions under non-coding selection: implications for transcriptional and post-transcriptional gene regulation." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=21995.

Full text

Abstract:

The signals that facilitate transcriptional and post-transcriptional gene expression regulation are still being understood. Comparative genomics approaches based on the premise that sequence or structure conservation implies functionality have successfully distinguished true regulatory sequences and structures from prediction noise. Protein-coding regions of genes have often been overlooked as potential regulatory sequence regions. A set of 8785 coding region sequences were previously found to be conserved significantly above a baseline protein-coding conservation level. We call these sequence

APA, Harvard, Vancouver, ISO, and other styles

2

Serra, Barros Ana Cristina. "Transcriptional regulation by non-coding RNAs in Saccharomyces cerevisiae." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:e523d0ee-bb3a-4217-aeba-9e6e398fc86a.

Full text

Abstract:

Genome-wide studies in Saccharomyces cerevisiae have revealed that the majority of the genome is transcribed on both strands, producing both coding and non-coding RNAs (ncRNAs). Initially, these ncRNAs were regarded as spurious transcripts but some have since been shown to have important roles as transcriptional regulators. Very little is understood about how ncRNAs are initiated, terminated and processed or how this influences their function. To address these questions, the expression, stability, and subcellular localization of the ncRNAs at the endogenous GAL locus was analysed. This reveale

APA, Harvard, Vancouver, ISO, and other styles

3

Snead, Aaron Nathan. "Exploring the non-transcriptional activity of thyroid hormone derivatives." Diss., Search in ProQuest Dissertations & Theses. UC Only, 2008. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3339205.

Full text

APA, Harvard, Vancouver, ISO, and other styles

4

Camilleri, Emily Therese. "The Transcriptional Role of FOXP1 in Non-Hodgkin's Lymphoma." Thesis, Griffith University, 2013. http://hdl.handle.net/10072/367974.

Full text

Abstract:

Non-Hodgkin's lymphoma (NHL) is a family of lymphoid malignances that are the 6th leading cause of death in Australia. B cell lymhomas account for approximately 90% of all NHL cases, and the common subtypes Diffuse Large B cell Lymphoma (DLBCL) and Follicular Lymphoma (FL) together make uo 60% of all cases. DLBCL and FL are both germinal centre derived B cell lymphomas, however these malignancies represent opposite ends of the clinical scale, being aggressive compared to indolent disease respectively. Early detection of lymphoma is highly advantageous for aggressive subtypes like DLBCL, where

APA, Harvard, Vancouver, ISO, and other styles

5

Bogu, Gireesh K. 1984. "Understanding the transcriptional landscape of non-coding genome in mammals." Doctoral thesis, Universitat Pompeu Fabra, 2017. http://hdl.handle.net/10803/572043.

Full text

Abstract:

Widespread transcription in mammals revealed unexpected discovery of non-coding elements like long noncoding RNAs (lncRNAs) and repetitive elements. First, lncRNAs were previously identified in limited number of tissues or cell lines in mouse and the discovery of lncRNAs was still pending in many other tissues in mouse. To address this, we applied a computational pipeline that discovered 2,803 highconfidence novel lncRNAs by mapping and de novo assembling billions of RNA-Seq reads in eight tissues and a primary cell line in mouse. Further, we integrated this catalog of lncRNAs with chro

APA, Harvard, Vancouver, ISO, and other styles

6

POLI, VALENTINA. "A non-transcriptional role of NFAT in regulating platelets functions." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2019. http://hdl.handle.net/10281/241337.

Full text

Abstract:

Le piastrine ricoprono un ruolo fondamentale nei processi di emostasi, ma, recentemente, è stato dimostrato che hanno anche un ruolo nel modulare la risposta infiammatoria, interagendo con le cellule del sistema immunitario in modo diretto e indiretto. Nonostante le piastrine siano delle cellule anucleate, esse contengono fattori trascrizionali (TF) che modulano la loro attivatione attraverso attività non-trascrizionali. In particolare, è stato dimostrato che le piastrine contengono NF-κB, un TF che controlla importanti funzioni delle cellule immunitarie durante i processi infiammatori, e che

APA, Harvard, Vancouver, ISO, and other styles

7

Evans, C. M. "Non-coding RNA and transcriptional regulation in CD4 T cell lineages." Thesis, University College London (University of London), 2015. http://discovery.ucl.ac.uk/1466165/.

Full text

Abstract:

CD4 T cell lineage choice epitomises the ability of the immune system to become tailored to a specific threat and provides a framework for understanding the mechanisms behind cell specification. The differentiation of T effectors from naïve cells gives rise to pro-inflammatory lineages including T helper 1 (Th1) and Th2 and anti-inflammatory regulatory T cells (Treg). An additional lineage of Treg also exits the thymus in parallel to naïve T cells and together these Treg are required for prevention of autoimmunity. These T cell lineages are distinct in terms of their cytokine production and fu

APA, Harvard, Vancouver, ISO, and other styles

8

Murfitt, Kenneth John. "Post-transcriptional regulation of miRNA activity and expression in C. elegans." Thesis, University of Cambridge, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.648749.

Full text

APA, Harvard, Vancouver, ISO, and other styles

9

Chery, Alicia. "Rôle de la transcription pervasive antisens chez Saccharomyces cerevisiae dans la régulation de l'expression des gènes." Thesis, Paris 6, 2017. http://www.theses.fr/2017PA066191/document.

Full text

Abstract:

L'expression des gènes est finement régulée dans la cellule et soumise à de multiples contrôles-qualité. Cette régulation intervient à différents niveaux, de façon à garantir une synthèse efficace des produits fonctionnels de l'expression génique, et pour assurer une adaptation à un changement environnemental. Notamment, les régulations transcriptionnelles sont cruciales pour contrôler la cinétique et le niveau d'expression des gènes. La transcription pervasive est une transcription généralisée non-codante et instable qui fut révélée chez la levure Saccharomyces cerevisiae. Bien que son potent

APA, Harvard, Vancouver, ISO, and other styles

10

Jones, Amy Madeline. "Post-transcriptional regulation of rpoS and HemA in salmonella." Morgantown, W. Va. : [West Virginia University Libraries], 2009. http://hdl.handle.net/10450/10826.

Full text

APA, Harvard, Vancouver, ISO, and other styles

11

Farhadi, Hooman F. "Evolutionarily conserved non-coding sequences confer transcriptional regulation to the Myelin Basic Protein gene." Thesis, McGill University, 2005. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=100359.

Full text

Abstract:

Myelin formation is an evolutionarily late acquisition that contributes to fast conduction in vertebrate axons. Continuous bidirectional signaling is required for the acquisition and maintenance of the mature nerve fiber phenotype. Myelin Basic Protein (MBP) is a representative structural component of compact myelin that is co-ordinately regulated with other myelin protein genes, primarily at the transcriptional level. In an effort to define the regulatory network controlling MBP expression, I located and functionally characterized conserved regulatory sequences in 5' non-coding sequence. Firs

APA, Harvard, Vancouver, ISO, and other styles

12

REY, FEDERICA. "TRANSCRIPTIONAL CHARACTERIZATION OF OBESITY AND TYPE 2 DIABETES: A FOCUS ON NON-CODING RNAS." Doctoral thesis, Università degli Studi di Milano, 2020. http://hdl.handle.net/2434/785913.

Full text

Abstract:

L’obesità è definita dall’Organizzazione Mondiale della Sanità come una condizione di accumulo di grasso corporeo anormale o eccessivo che può presentare un rischio per la salute. Questa malattia può portare all’insorgenza di comorbidità associate quali il diabete di tipo 2, l’ipertensione, malattie cardiovascolari, dislipidemia, infarto, artrite e anche alcuni tipi di cancro, con un conseguente aumento della mortalità. Il contributo relativo di fattori genetici o dell’ambiente nell’insorgenza dell’obesità non è ancora chiaramente definito, e gli RNA regolatori potrebbero avere una funzione fo

APA, Harvard, Vancouver, ISO, and other styles

13

Chery, Alicia. "Rôle de la transcription pervasive antisens chez Saccharomyces cerevisiae dans la régulation de l'expression des gènes." Electronic Thesis or Diss., Paris 6, 2017. http://www.theses.fr/2017PA066191.

Full text

Abstract:

L'expression des gènes est finement régulée dans la cellule et soumise à de multiples contrôles-qualité. Cette régulation intervient à différents niveaux, de façon à garantir une synthèse efficace des produits fonctionnels de l'expression génique, et pour assurer une adaptation à un changement environnemental. Notamment, les régulations transcriptionnelles sont cruciales pour contrôler la cinétique et le niveau d'expression des gènes. La transcription pervasive est une transcription généralisée non-codante et instable qui fut révélée chez la levure Saccharomyces cerevisiae. Bien que son potent

APA, Harvard, Vancouver, ISO, and other styles

14

Souslova, Tatiana. "Transcriptional Regulatory Mechanisms of Freud-1, a Novel Mental Retardation Gene." Thèse, Université d'Ottawa / University of Ottawa, 2011. http://hdl.handle.net/10393/20044.

Full text

Abstract:

The mechanisms that govern the repression of 5-HT1A receptor gene expression mediated by a novel mental retardation gene, Freud-1, were examined in HEK293 and SKNSH cells. This study provides a possible mechanism of 5-HT1A receptor gene regulation by Freud-1, which, to mediate its action, recruits Swi/Snf and Sin3A/histone deacetylase (HDAC) complexes in non-neuronal HEK293 cells and Swi/Snf only in neuronal, 5-HT1A receptor-expressing SKNSH cells. Thus, Freud-1 has a dual mechanism of repression depending on cell type: HDAC dependent in HEK293 cells and HDAC independent in SKNSH cells. In add

APA, Harvard, Vancouver, ISO, and other styles

15

Kolar-Znika, Lorena. "Study of the organisation and the transcriptional activity of mouse major satellites." Thesis, Paris 6, 2015. http://www.theses.fr/2015PA066156/document.

Full text

Abstract:

Dans les cellules de souris, l'hétérochromatine péricentromérique, caractérisée par les répétitions des satellites majeurs et une signature épigénétique spécifique, la triméthylation de l'histone H3 sur la lysine 9 (H3K9me3), est organisée en structures nucléaires particulières appelées chromocentres. Cette région est transcriptionnellement active, produisant des ARN non-codants. Pour caractériser le profil transcriptionnel des satellites majeurs, nous avons utilisé des oligonucléotides LNA séquence spécifiques, pour des expériences de northern blot. Nous avons mis en évidence un profil de tra

APA, Harvard, Vancouver, ISO, and other styles

16

Fraser, Sherri D. "Post-transcriptional regulation by non-coding sequences of the c-myc transcript in Xenopus laevis." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/nq20736.pdf.

Full text

APA, Harvard, Vancouver, ISO, and other styles

17

Chen, Dongsheng. "Transcriptional regulation of the p9Ka gene in metastatic and non-metastatic rat mammary epithelial cells." Thesis, University of Liverpool, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.266488.

Full text

APA, Harvard, Vancouver, ISO, and other styles

18

Niemczyk, Malwina. "Epigenetic and transcriptional relationship between a novel long non-coding RNA GNG12-AS1 and imprinted DIRAS3." Thesis, University of Cambridge, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.708234.

Full text

APA, Harvard, Vancouver, ISO, and other styles

19

Siouda, Maha. "Transcriptional regulation and epigenetic repression of the tumor suppressor DOK1 in viral- and non viral-related carcinogenesis." Thesis, Lyon 1, 2013. http://www.theses.fr/2013LYO10163.

Full text

Abstract:

Le suppresseur de tumeur DOK1 (downstream of tyrosine kinases1) est une protéine régulatrice de voies de signalisation impliquées dans des processus cellulaires tel que la prolifération, la migration et l'apoptose. Le rôle suppresseur de tumeur de DOK1 a été démontré dans des modèles animaux. Les souris knock-out pour DOK1 présentent une forte susceptibilité de développer des leucémies, des tumeurs malignes hématologiques, des adénocarcinomes pulmonaires, ainsi que des sarcomes histiocytaires agressifs. En outre, nous avons rapporté précédemment que le gène DOK1 peut être muté et son expressio

APA, Harvard, Vancouver, ISO, and other styles

20

Wang, Xiangting. "Stress-induced non-coding RNAs allosterically regulate TLS, a HAT-inhibitory RNA binding protein, to mediate transcriptional repression." Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2007. http://wwwlib.umi.com/cr/ucsd/fullcit?p3254429.

Full text

Abstract:

Thesis (Ph. D.)--University of California, San Diego, 2007.<br>Title from first page of PDF file (viewed May 2, 2007). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references (p. 69-83).

APA, Harvard, Vancouver, ISO, and other styles

21

Tran, Van Giang. "Régulation de l'expression du gène Igf2 : nouveaux promoteurs et implication de longs ARN non-codants." Thesis, Montpellier 2, 2014. http://www.theses.fr/2014MON20022/document.

Full text

Abstract:

L'expression du gène Igf2, qui est soumis à l'empreinte génomique parentale chez les mammifères, est hautement régulée au cours du développement embryonnaire et de la période périnatale grâce à divers mécanismes transcriptionnels et post-transcriptionnels. Ces mécanismes mettent à contribution de longs ARN non codants produits au sein même du locus, dont le plus connu est l'ARN H19. En utilisant une approche de complémentation génétique par un transgène H19 dans myoblastes H19 KO de souris, nous démontrons l'existence de plusieurs nouveaux promoteurs d'Igf2. L'un de ces promoteurs, qui est con

APA, Harvard, Vancouver, ISO, and other styles

22

Musahl, Anne-Susann [Verfasser]. "Transcriptional characterization and functional analysis of long non-coding RNA/protein-coding gene pairs encoded in the human genome / Anne-Susann Musahl." Berlin : Freie Universität Berlin, 2015. http://d-nb.info/1075493706/34.

Full text

APA, Harvard, Vancouver, ISO, and other styles

23

Dam, Sushovan. "Post-transcriptional regulation of porin expression in Escherichia coli and its impact on antibiotic resistance." Thesis, Aix-Marseille, 2018. http://www.theses.fr/2018AIXM0641/document.

Full text

Abstract:

Chez les bactéries à Gram-négatif, l’imperméabilité de la membrane externe est un facteur majeur contribuant au développement de la résistance. Chez Escherichia coli, les porines OmpF et OmpC sont des protéines de la membrane externe qui forment des canaux pour la diffusion de petites molécules hydrophiles tels que les antibiotiques. L’expression des porines est soumise à une régulation fine, et des petits ARN non-codants (sRNAs, small RNAs) jouent un rôle important au niveau post-transcriptionnel. Dans ce cadre, et en utilisant E. coli comme bactérie modèle, les objectifs de mon travail de th

APA, Harvard, Vancouver, ISO, and other styles

24

Brown, Robert Vincent. "The Regulatory Significance and Molecular Targeting of Novel Non-B-DNA Secondary Structures Formed from the PDGFR-Beta Core Promoter Nuclease Hypersensitivity Element." Diss., The University of Arizona, 2014. http://hdl.handle.net/10150/337361.

Full text

APA, Harvard, Vancouver, ISO, and other styles

25

Vitsios, Dimitrios. "Elucidating the function and biogenesis of small non-coding RNAs using novel computational methods & machine learning." Thesis, University of Cambridge, 2017. https://www.repository.cam.ac.uk/handle/1810/273493.

Full text

Abstract:

The discovery of RNA in 1868 by Friedrich Miescher was meant to be the prologue to an exciting new era in Biology full of scientific breakthroughs and accomplishments. Since then, RNAs have been proven to play an indispensable role in biological processes such as coding, decoding, regulation and expression of genes. In particular, the discovery of small non-coding RNAs and especially miRNAs, in C. elegans first and thereafter to almost all animals and plants, started to fill in the puzzle of a complex gene regulatory network present within cells. The aim of this thesis is to shed more light on

APA, Harvard, Vancouver, ISO, and other styles

26

Dequivre, Magali. "Implication des ARN non codant dans la virulence du phytopathogène Agrobacterium fabrum C58." Thesis, Lyon 1, 2015. http://www.theses.fr/2015LYO10016/document.

Full text

Abstract:

L'une des caractéristiques majeures des microorganismes, et donc des bactéries, est qu'ils sont en contact direct avec l'environnement et doivent donc percevoir et répondre rapidement à ses variations. Pour cela, plusieurs niveaux de contrôle existent, et récemment le rôle des ARN non codants régulateurs, ou riborégulateurs, a été mis en lumière comme un mécanisme de contrôle peu couteux et rapide pour la cellule. Chez le phytopathogène Agrobacterium fabrum (anciennement appelé Agrobaterium tumefaciens), la virulence est principalement régulée au niveau transcriptionnel par le système à deux c

APA, Harvard, Vancouver, ISO, and other styles

27

Dangin, Mathieu. "Contrôle de la différenciation sexuelle de la levure Schizosaccharomyces pombe par un ARN non-codant et la protéine de liaison à l’ARN Mmi1." Thesis, Université Grenoble Alpes (ComUE), 2017. http://www.theses.fr/2017GREAV079/document.

Full text

Abstract:

Au cours des cinq dernières années l’existence d’un contrôle de la transcription par les ARN non-codants longs (lncRNAs) a été décrite dans une large variété d’eucaryotes. Cependant, les mécanismes par lesquels les lncRNAs régulent la transcription restent en grande partie méconnus. Les premiers travaux effectués dans le cadre de cette thèse ont participé à la caractérisation du mécanisme mis en jeu par un lncRNA, nommé nam1, dans le contrôle de l’entrée en différenciation sexuelle chez la levure Schizosaccharomyces pombe. Il a ainsi été montré qu’au cours de sa synthèse le lncRNA nam1 est cib

APA, Harvard, Vancouver, ISO, and other styles

28

Frapporti, Andrea. "Programmed genome rearrangements in Paramecium tetraurelia : identification of Ezl1, a dual histone H3 lysine 9 and 27 methyltransferase." Thesis, Sorbonne Paris Cité, 2016. http://www.theses.fr/2016USPCC250.

Full text

Abstract:

Chez les eucaryotes, le génome est organisé en chromatine, une structure nucléoprotéique essentielle pour la régulation de l’expression génique ainsi que pour le maintien de la stabilité du génome. Les ciliés sont d’excellents organismes modèles pour étudier les mécanismes généraux qui maintiennent l’intégrité du génomes eucaryote. Chez Paramecium tetraurelia, la différentiation du génome somatique à partir du génome germinal est caractérisée par des événements massifs et reproductibles d’élimination d’ADN. D’une part, des éléments répétés (transposons,régions minisatellites), de plusieurs kil

APA, Harvard, Vancouver, ISO, and other styles

29

Richard, Audrey. "Oncolytic H-1 parvovirus NS1 protein : identifying and characterizing new transcriptional and posttranslational regulatory elements." Phd thesis, Université du Droit et de la Santé - Lille II, 2011. http://tel.archives-ouvertes.fr/tel-00826936.

Full text

Abstract:

H 1 parvovirus (H-1PV) is a little single stranded DNA virus that preferentially replicates in a lytic manner in transformed cells due to their expression profile that meets the requirements for the activation of H¬ 1 PV life cycle unlike normal cells. This feature is known as oncotropism. H 1PV genome is constituted by two transcriptional units. The first one is driven by the proliferation and transformation dependent P4 promoter and allows the expression of both non structural proteins NS1 and NS2, and the second one controls the expression of both capsid proteins VP1 and VP2 through the act

APA, Harvard, Vancouver, ISO, and other styles

30

Ding, Shuai. "Characterization of P.falciparum histone methyltransferases : biological role and possible targets for new intervention strategies." Thesis, Paris 6, 2016. http://www.theses.fr/2016PA066578/document.

Full text

Abstract:

On a montré que les PTM jouaient un rôle significatif de P. falciparum dans l'année de contrôle de la régulation transcriptionnelle, de l'expression monoaléique et de la différenciation sexuelle. Dix SET contenant des HKMTs contenant du domaine-ont été prédits; Six d'entre eux être essentiels pour le développement de stages de sang asexués. Le projet de thèse est centré sur la caractérisation biologique de PfSET7 et PfSET6. Nous avons observé l'échange de localisation cellulaire dynamique Pendant le cycle de vie: PfSET7 se trouvent dans de multiples foyers cytoplasmiques dans les stades érythr

APA, Harvard, Vancouver, ISO, and other styles

31

Bardou, Florian. "Les AtNSRs, protéines régulatrices de l’épissage alternatif et du silencing post transcriptionnel." Thesis, Paris 11, 2013. http://www.theses.fr/2013PA112054/document.

Full text

Abstract:

Chez les eucaryotes, plusieurs protéines liant l'ARN ou RBPs agissent sur l'ARNm à différents niveaux, de l'épissage à la traduction. Récemment, un grand nombre d’ARN non-codant des protéines (npcRNAs) ont été identifiés chez les eucaryotes et ont été montré comme interagissant avec une variété de ribonucléoprotéines (RNP) pour contrôler l'expression des gènes au niveau post-transcriptionnel. Nous avons identifié une Nuclear-Speckle RBP (ou NSR) qui interagit avec le npcRNA, ENOD40, un lncARN qui s'accumule au cours de la formation des racines latérales et des nodules chez les légumineuses. Du

APA, Harvard, Vancouver, ISO, and other styles

32

Cedrone, L. "THE ROLE OF ENHANCED POLYCOMB REPRESSIVE COMPLEX 2 ACTIVITY IN TUMORIGENESIS." Doctoral thesis, Università degli Studi di Milano, 2017. http://hdl.handle.net/2434/468289.

Full text

Abstract:

Polycomb Group of proteins are essential factors present in cells’ nuclei. These multiprotein complexes are key repressive chromatin factors that regulate cellular differentiation during development, contributing to the correct establishment of lineage-specific transcriptional programs. Moreover, they represent key factors of proliferation and deregulation of their levels and activity have been linked to the onset and development of several human cancers. Recently, gain of function heterozygous EZH2 mutations have been discovered in non-Hodgkin lymphomas and melanomas. These mutations cause a

APA, Harvard, Vancouver, ISO, and other styles

33

Rasschaert, Perrine. "Régulation transcriptionnelle et post-transcriptionnelle des gênes LAT et ICP4 du virus de la maladie de Marek." Thesis, Tours, 2015. http://www.theses.fr/2015TOUR4011/document.

Full text

Abstract:

Le virus de la maladie de Marek (MDV) est un virus oncogène responsable des lymphomes T chez les poulets. L´infection par ce virus est divisée en une phase lytique dépendante de l´expression du gène très précoce ICP4 et une phase latente, caractérisée par l´expression de l’ARN long non codant LAT localisé en antisens. Nous avons montré que l’expression différentielle des miARN du cluster mdv1-miR-M8-M10 était directement corrélée à l’épissage alternatif de l’intron 1 du LAT et plus particulièrement à la biogenèse par le splicéosome du premier mirtron viral. La présence du mirtron mdv1-miR-M6 a

APA, Harvard, Vancouver, ISO, and other styles

34

Bovolenta, Luiz Augusto. "Análise exploratória em larga escala de microRNAs expressos em tilápia do Nilo utilizando ferramentas de bioinformática." Botucatu, 2016. http://hdl.handle.net/11449/148567.

Full text

Abstract:

Orientador: Ney Lemke<br>Resumo: MicroRNAs (miRNAs) são pequenas moléculas de RNA que regulam pós-transcricionalmente a expressão de genes, modelando o transcriptoma e a produção de proteínas. Em geral, os miRNAs são conservados no genoma de eucariotos, sendo considerados elementos vitais em diversos processos biológicos durante o desenvolvimento, tais como crescimento, diferenciação e morte celular. A grande diversidade de miRNAs identificados está restrita a poucas espécies e apenas uma parte do total de alvos de miRNAs preditos foi caracterizada funcionalmente. Nesse contexto, o uso da tecn

APA, Harvard, Vancouver, ISO, and other styles

35

Ding, Shuai. "Characterization of P.falciparum histone methyltransferases : biological role and possible targets for new intervention strategies." Electronic Thesis or Diss., Paris 6, 2016. https://accesdistant.sorbonne-universite.fr/login?url=https://theses-intra.sorbonne-universite.fr/2016PA066578.pdf.

Full text

Abstract:

On a montré que les PTM jouaient un rôle significatif de P. falciparum dans l'année de contrôle de la régulation transcriptionnelle, de l'expression monoaléique et de la différenciation sexuelle. Dix SET contenant des HKMTs contenant du domaine-ont été prédits; Six d'entre eux être essentiels pour le développement de stages de sang asexués. Le projet de thèse est centré sur la caractérisation biologique de PfSET7 et PfSET6. Nous avons observé l'échange de localisation cellulaire dynamique Pendant le cycle de vie: PfSET7 se trouvent dans de multiples foyers cytoplasmiques dans les stades érythr

APA, Harvard, Vancouver, ISO, and other styles

36

Saadeh, Bashir. "Characterization and search for virulence-related factors in “Classical” and “New” Brucella species." Thesis, Montpellier 1, 2013. http://www.theses.fr/2013MON1T010/document.

Full text

Abstract:

L'étude qu'on a entreprise a pour but d'analyser les facteurs de virulence des espèces "Classiques" et "nouvelles" de Brucella. Dans cette perspective, on a analysé les génomes des espèces récemment découvertes : Brucella inopinata BO1 et Brucella inopinata-like BO2, isolés pour la première fois de patients humains sans réservoir animal connu. On a découvert que ces deux espèces possèdent des profils de restriction uniques. De plus, BO2 possède deux chromosomes de taille identique, un profil jamais décrit pour une autre espèce de Brucella. L'analyse de la réplication intracellulaire de ces deu

APA, Harvard, Vancouver, ISO, and other styles

37

Otto, Wolfgang. "Transcriptional Regulatory Elements." Doctoral thesis, Universitätsbibliothek Leipzig, 2011. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-78960.

Full text

Abstract:

A major challenge in life sciences is the understanding of mechanisms that regulate the expression of genes. An important step towards this goal is the ability to identify transcriptional regulatory elements like binding sites for transcription factors. In computational biology, a popular approach for this task is comparative sequence analysis using both distantly as well as closely related species. Although this method has successfully identified conserved regulatory regions, the majority of binding sites can change rapidly even between closely related species. This makes it difficult to dete

APA, Harvard, Vancouver, ISO, and other styles

38

Li, Witharana Wing Kar. "Non-Boolean characterization of Homer1a intranuclear transcription foci." Thesis, Lethbridge, Alta. : University of Lethbridge, Dept. of Neuroscience, c2011, 2011. http://hdl.handle.net/10133/3402.

Full text

Abstract:

Activity-induced immediate-early gene (IEG) transcription foci can be labelled with fluorescent probes, permitting high temporal and spatial resolution in mapping neuronal circuits. Previous quantification approaches have assumed a Boolean function of transcription foci, assuming that cells are either active or inactive. Due to multiple amplification steps in the in situ hybridization process, it was thought that information relating to magnitudes of firing rates was lost. However, the current data suggest that transcription foci actually exhibit non-Boolean intensity and size values which var

APA, Harvard, Vancouver, ISO, and other styles

39

Dermawan, Josephine Kam Tai. "From NF-κB to FACT: Mechanisms and Translational Applications of EGFR-mediated NF-κB Regulation". Case Western Reserve University School of Graduate Studies / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=case1436292263.

Full text

APA, Harvard, Vancouver, ISO, and other styles

40

Nguyen, Tania. "Complex transcription units in Saccharomyces cerevisiae." Thesis, University of Oxford, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.711667.

Full text

APA, Harvard, Vancouver, ISO, and other styles

41

Ard, Ryan Anthony. "Functional long non-coding RNA transcription in Schizosaccharomyces pombe." Thesis, University of Edinburgh, 2016. http://hdl.handle.net/1842/20396.

Full text

Abstract:

Eukaryotic genomes are pervasively transcribed and frequently generate long noncoding RNAs (lncRNAs). However, most lncRNAs remain uncharacterized. In this work, a set of positionally conserved intergenic lncRNAs in the fission yeast Schizosaccharomyces pombe genome are selected for further analysis. Deleting one of these lncRNA genes (ncRNA.1343) exhibited a clear phenotype: increased drug sensitivity. Further analyses revealed that deleting ncRNA.1343 also disrupted a previously unannotated lncRNA, termed nc-tgp1, transcribed in the opposite orientation of the predicted ncRNA.1343 gene and i

APA, Harvard, Vancouver, ISO, and other styles

42

Vujovic, Filip. "Bimodal Transcription Regulates Non-Canonical Signaling of Notch 1." Thesis, The University of Sydney, 2019. http://hdl.handle.net/2123/21166.

Full text

Abstract:

Notch is a critical determinant of tissue organisation in metazoan development. The activation of Notch signaling is based on ligand-receptor interaction, consequentially the activated intracellular Notch domain is chaperoned into the nuclear compartment where it acts as a transcriptional activator for Notch target genes, leading to a biological outcome that may or may not be predictable. Upon activation, downstream signals contribute to resolution of dichotomies such as proliferation/differentiation or sub-lineage differentiation outcome. Idiosyncratic outcomes are common, leading experimenta

APA, Harvard, Vancouver, ISO, and other styles

43

Holmqvist, Erik. "Macromolecular Matchmaking : Mechanisms and Biology of Bacterial Small RNAs." Doctoral thesis, Uppsala universitet, Mikrobiologi, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-171642.

Full text

Abstract:

Cells sense the properties of the surrounding environment and convert this information into changes in gene expression. Bacteria are, in contrast to many multi-cellular eukaryotes, remarkable in their ability to cope with rapid environmental changes and to endure harsh and extreme milieus. Previously, control of gene expression was thought to be carried out exclusively by proteins. However, it is now clear that small regulatory RNAs (sRNA) also carry out gene regulatory functions. Bacteria such as E. coli harbor a large class of sRNAs that bind to mRNAs to alter translation and/or mRNA stabili

APA, Harvard, Vancouver, ISO, and other styles

44

Cheng, Tian. "Exploiting piano acoustics in automatic transcription." Thesis, Queen Mary, University of London, 2016. http://qmro.qmul.ac.uk/xmlui/handle/123456789/18421.

Full text

Abstract:

In this thesis we exploit piano acoustics to automatically transcribe piano recordings into a symbolic representation: the pitch and timing of each detected note. To do so we use approaches based on non-negative matrix factorisation (NMF). To motivate the main contributions of this thesis, we provide two preparatory studies: a study of using a deterministic annealing EM algorithm in a matrix factorisation-based system, and a study of decay patterns of partials in real-word piano tones. Based on these studies, we propose two generative NMF-based models which explicitly model different piano aco

APA, Harvard, Vancouver, ISO, and other styles

45

Balthasar, Lukas. "Interaction audio-visuelle : théorie pragma-linguistique et transcription." Paris, EHESS, 2001. http://www.theses.fr/2001EHES0087.

Full text

APA, Harvard, Vancouver, ISO, and other styles

46

Herzel, Lydia. "Co-transcriptional splicing in two yeasts." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-179274.

Full text

Abstract:

Cellular function and physiology are largely established through regulated gene expression. The first step in gene expression, transcription of the genomic DNA into RNA, is a process that is highly aligned at the levels of initiation, elongation and termination. In eukaryotes, protein-coding genes are exclusively transcribed by RNA polymerase II (Pol II). Upon transcription of the first 15-20 nucleotides (nt), the emerging nascent RNA 5’ end is modified with a 7-methylguanosyl cap. This is one of several RNA modifications and processing steps that take place during transcription, i.e. co-trans

APA, Harvard, Vancouver, ISO, and other styles

47

Böhm, Stefanie. "Non-protein-coding RNA : Transcription and regulation of ribosomal RNA." Doctoral thesis, Stockholms universitet, Institutionen för molekylär biovetenskap, Wenner-Grens institut, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-102718.

Full text

Abstract:

Cell growth and proliferation are processes in the cell that must be tightly regulated. Transcription of ribosomal RNA and ribosomal biogenesis are directly linked to cell growth and proliferation, since the ribosomal RNA encodes for the majority of transcription in a cell and ribosomal biogenesis influences directly the number of proteins that are synthesized. In the work presented in this thesis, we have investigated the ribosomal RNA genes, namely the ribosomal DNA genes and the 5S rRNA genes, and their transcriptional regulation. One protein complex that is involved in RNA polymerase I and

APA, Harvard, Vancouver, ISO, and other styles

48

Warthi, Ganesh Daulatrao. "Exploration de mécanismes de transcription et de traduction non-canoniques." Thesis, Aix-Marseille, 2019. http://www.theses.fr/2019AIXM0587.

Full text

Abstract:

Le séquencage d'ARN et la spectrométrie de masse génèrent des RNA reads et des spectres peptidiques non-homologues à l'ADN. Les ignorer cause la perte d'informations génétiques. Nous explorons deux transcription noncanoniques, identifiant et expliquant RNAs et peptides mitochondriaux humains (non prédits par le genome nucléaire). 1) Échanges nucléotidiques systématiques: les échanges systématiques de nucleotides dans l'ARN (swinger RNA, 23 échanges, 9 symmétriques (X↔Y) et 14 asymmétriques (X→Y→Z→X). Les résultats sur les swinger ARNs sont reproductibles entre transcriptomes de souches mitocho

APA, Harvard, Vancouver, ISO, and other styles

49

Xiao, Lei. "Transcriptional Regulation of the Xenopus MyoD Gene." Diss., lmu, 2003. http://nbn-resolving.de/urn:nbn:de:bvb:19-11960.

Full text

APA, Harvard, Vancouver, ISO, and other styles

50

Bothe, Anna Melissa [Verfasser]. "Investigating the Genomic Effects of Glucocorticoid Receptor Activation : An Analysis of Transcriptional Memory and Mechanisms That Direct Divergent Genomic Occupancy of Related Transcription Factors / Anna Melissa Bothe." Berlin : Freie Universität Berlin, 2021. http://nbn-resolving.de/urn:nbn:de:kobv:188-refubium-31999-3.

Full text

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!