Relevant bibliographies by topics / Non-lymphoid tissue regulatory t cells

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  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers

Academic literature on the topic 'Non-lymphoid tissue regulatory t cells'

Author: Grafiati
Published: 3 November 2022

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Journal articles on the topic "Non-lymphoid tissue regulatory t cells"

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Barros, Leandro, Cristina Ferreira, and Marc Veldhoen. "The fellowship of regulatory and tissue-resident memory cells." Mucosal Immunology 15, no. 1 (2021): 64–73. http://dx.doi.org/10.1038/s41385-021-00456-w.

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AbstractT cells located in non-lymphoid tissues have come to prominence in recent years. CD8+ tissue-resident memory (Trm) cells are important for tissue immune surveillance, provide an important line of defence against invading pathogens and show promise in cancer therapies. These cells differ in phenotype from other memory populations, are adapted to the tissue they home to where they found their cognate antigen and have different metabolic requirements for survival and activation. CD4+ Foxp3+ regulatory T (Treg) cells also consist of specialised populations, found in non-lymphoid tissues, w
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DiSpirito, Joanna R., David Zemmour, Deepshika Ramanan, et al. "Molecular diversification of regulatory T cells in nonlymphoid tissues." Science Immunology 3, no. 27 (2018): eaat5861. http://dx.doi.org/10.1126/sciimmunol.aat5861.

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Foxp3+CD4+regulatory T cells (Tregs) accumulate in certain nonlymphoid tissues, where they control diverse aspects of organ homeostasis. Populations of tissue Tregs, as they have been termed, have transcriptomes distinct from those of their counterparts in lymphoid organs and other nonlymphoid tissues. We examined the diversification of Tregsin visceral adipose tissue, skeletal muscle, and the colon vis-à-vis lymphoid organs from the same individuals. The unique transcriptomes of the various tissue Tregpopulations resulted from layering of tissue-restricted open chromatin regions over regions
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Ley, Klaus. "The second touch hypothesis: T cell activation, homing and polarization." F1000Research 3 (February 5, 2014): 37. http://dx.doi.org/10.12688/f1000research.3-37.v1.

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The second touch hypothesis states that T cell activation, proliferation, induction of homing receptors and polarization are distinguishable and, at least in part, sequential. The second touch hypothesis maintains that full T cell polarization requires T cell interaction with antigen-presenting cells (DCs, macrophages, B cells and certain activated stromal cells) in the non-lymphoid tissue where the antigen resides. Upon initial antigen encounter in peripheral lymph nodes (PLN), T cells become activated, proliferate and express homing receptors that enable them to recirculate to the (inflamed)
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Ley, Klaus. "The second touch hypothesis: T cell activation, homing and polarization." F1000Research 3 (August 4, 2014): 37. http://dx.doi.org/10.12688/f1000research.3-37.v2.

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The second touch hypothesis states that T cell activation, proliferation, induction of homing receptors and polarization are distinguishable and, at least in part, sequential. The second touch hypothesis maintains that full T cell polarization requires T cell interaction with antigen-presenting cells (DCs, macrophages, B cells and certain activated stromal cells) in the non-lymphoid tissue where the antigen resides. Upon initial antigen encounter in peripheral lymph nodes (PLN), T cells become activated, proliferate and express homing receptors that enable them to recirculate to the (inflamed)
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Gu, Yisu, Emily Thornton, and Fiona Powrie. "Spatial Compartmentalisation of T Regulatory Cells within Intestinal Lymphoid Tissue." Biology of Blood and Marrow Transplantation 25, no. 3 (2019): S297. http://dx.doi.org/10.1016/j.bbmt.2018.12.676.

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Daynes, R. A., B. A. Araneo, T. A. Dowell, K. Huang, and D. Dudley. "Regulation of murine lymphokine production in vivo. III. The lymphoid tissue microenvironment exerts regulatory influences over T helper cell function." Journal of Experimental Medicine 171, no. 4 (1990): 979–96. http://dx.doi.org/10.1084/jem.171.4.979.

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We investigated the capacity of murine T lymphocytes, isolated from various lymphoid organs of normal or antigen-primed donors, to produce IL-2 or IL-4 after activation with anti-CD3 or specific antigen. Our results established that T cells resident within lymphoid organs being drained by nonmucosal tissue sites (e.g., axillary, inguinal, brachial lymph nodes, or spleen) produced IL-2 as the predominant T cell growth factor (TCGF) after activation. Conversely, activated T cells from lymphoid organs being drained by mucosal tissues (Peyer's patches, and cervical, periaortic, and parathymic lymp
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Peters, Jorieke H., Hans J. P. M. Koenen, Esther Fasse, et al. "Human secondary lymphoid organs typically contain polyclonally-activated proliferating regulatory T cells." Blood 122, no. 13 (2013): 2213–23. http://dx.doi.org/10.1182/blood-2013-03-489443.

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Key Points The majority of suppressive Tregs in human secondary lymphoid organs are activated, produce cytokines, and proliferate. Human lymphoid organs may provide a platform for in vivo expansion of infused Tregs and subsequent tissue-directed homing.
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Hewavisenti, Rehana V., Angela L. Ferguson, Georgia Gasparini, et al. "Tissue‐resident regulatory T cells accumulate at human barrier lymphoid organs." Immunology & Cell Biology 99, no. 8 (2021): 894–906. http://dx.doi.org/10.1111/imcb.12481.

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Kocks, Jessica R., Ana Clara Marques Davalos-Misslitz, Gabriele Hintzen, Lars Ohl, and Reinhold Förster. "Regulatory T cells interfere with the development of bronchus-associated lymphoid tissue." Journal of Experimental Medicine 204, no. 4 (2007): 723–34. http://dx.doi.org/10.1084/jem.20061424.

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Presence and extent of bronchus-associated lymphoid tissue (BALT) is subject to considerable variations between species and is only occasionally observed in lungs of mice. Here we demonstrate that mice deficient for the chemokine receptor CCR7 regularly develop highly organized BALT. These structures were not present at birth but were detectable from day 5 onwards. Analyzing CCR7−/−/wild-type bone marrow chimeras, we demonstrate that the development of BALT is caused by alterations of the hematopoietic system in CCR7-deficient mice. These observations together with the finding that CCR7-defici
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Graca, Luis, Stephen P. Cobbold, and Herman Waldmann. "Identification of Regulatory T Cells in Tolerated Allografts." Journal of Experimental Medicine 195, no. 12 (2002): 1641–46. http://dx.doi.org/10.1084/jem.20012097.

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Induction of transplantation tolerance with certain therapeutic nondepleting monoclonal antibodies can lead to a robust state of peripheral “dominant” tolerance. Regulatory CD4+ T cells, which mediate this form of “dominant” tolerance, can be isolated from spleens of tolerant animals. To determine whether there were any extra-lymphoid sites that might harbor regulatory T cells we sought their presence in tolerated skin allografts and in normal skin. When tolerated skin grafts are retransplanted onto T cell–depleted hosts, graft-infiltrating T cells exit the graft and recolonize the new host. T
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Dissertations / Theses on the topic "Non-lymphoid tissue regulatory t cells"

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Nikitin, Artemii. "Role of nuclear receptor RORα in regulatory T cells". Thesis, Université de Lille (2018-2021), 2019. http://www.theses.fr/2019LILUS073.

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Les facteurs de transcription de la superfamille des récepteurs nucléaires jouent de multiples rôles dans le développement et la fonction des lymphocytes T régulateurs (TREG). Les TREG sont des cellules régulatrices/suppressives qui contrôlent les réponses d’autres types cellulaires et l’homéostasie locale des tissus.Comme les TREG sont actives au sein de divers organes, tant à l’homéostasie qu’en conditions inflammatoires,ils doivent répondre à la fois aux contexte local au sein du tissus et à un environnement immunologiquement agressif tout en préservant leurs propriétés tolérogéniques au co
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Audemard-Verger, Alexandra. "Caractérisation des lymphocytes T résidents des organes lymphoïdes secondaires à l’état basal." Thesis, Sorbonne Paris Cité, 2017. http://www.theses.fr/2017USPCB260/document.

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Une résidence à long terme de lymphocytes T (LTs) au sein de la plupart des tissus non lymphoïdes a été récemment décrite, notamment à la suite d’infections. Ces cellules confèreraient à l’hôte une meilleure protection en cas de réinfection. À l'aide de deux approches expérimentales différentes, l'injection d'anticorps bloquant l’entrée des LTs dans les ganglions lymphatiques (LNs) et la génération de parabioses par chirurgie, nous avons pu mettre en évidence, à l’état basal, la résidence d’une proportion significative des LTs αβ mémoires CD4+, des LTs αβ régulateurs CD4+ et d’une sous-populat
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Wu, Hao. "Regulation of the germinal center reaction by T helper cells and T regulatory cells." Diss., 2016. http://hdl.handle.net/1805/10478.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>Germinal Centers (GCs) are transient lymphoid structures that arise in lymphoid organs in response to T cell-dependent antigen. Within the GC, follicular T helper (TFH) cells promote GC B cell differentiation and in turn the proper antibody production to protect us from invading pathogens. We wished to study the regulation of this process by transcription factors STAT3 and Bcl6. STAT3 is important for both TFH cell differentiation and IL-4 production by Th2 cells. IL-4 is a major functional cytokine produced by TFH cells. To dissect
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Lin, Wen-Hsin, and 林雯歆. "Stilbenes of peanut sprouts exhibit phytoestrogenic activity in promoting regulatory T cell functions of both peripheral and central lymphoid tissues." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/27766508606611320220.

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碩士<br>國立嘉義大學<br>微生物免疫與生物藥學系研究所<br>99<br>Background：Alterations in immunity that occur with aging (immunosenescence) likely contribute to the development of autoimmune diseases. CD4＋CD25＋Foxp3＋ regulatory T cells (Treg) play an immunosuppressive role in immune system. They are responsible in the maintaining of immunological self-tolerance as well as immunohomeostasis. Age-associated increases in the population of Treg protect host against autoimmune diseases. Estrogen is known to increase Treg activity in facilitating immunological tolerance to fetal antigens. Stilbenes are known possessing ph
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Books on the topic "Non-lymphoid tissue regulatory t cells"

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van der Vlag, Johan, and Jo H. M. Berden. The patient with systemic lupus erythematosus. Edited by Giuseppe Remuzzi. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199592548.003.0161.

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Systemic lupus erythematosus (SLE) is a systemic autoimmune disease with various clinical manifestations. The hallmark of SLE is the presence of antibodies against nuclear constituents, such as double-stranded (ds)DNA, histones, and nucleosomes. Local deposition of antinuclear antibodies in complex with nuclear autoantigens induces serious inflammatory conditions that can affect several tissues and organs, including the kidney.The levels of antinucleosome and anti-dsDNA antibodies seem to correlate with glomerulonephritis and these autoantibodies can often be detected years before the patient
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Book chapters on the topic "Non-lymphoid tissue regulatory t cells"

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Ward, Eleanor Jayne, Hongmei Fu, and Federica Marelli-Berg. "Monitoring Migration of Activated T Cells to Antigen-Rich Non-lymphoid Tissue." In Methods in Molecular Biology. Springer New York, 2017. http://dx.doi.org/10.1007/978-1-4939-6931-9_15.

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W. Hoskin, D., R. A. Murgita, S. Hamel, and K.-O. Gronvik. "PREGNANCY INTERRUPTION BY A MONOCLONAL ANTIBODY THAT RECOGNIZES NON-T SUPPRESSOR CELLS IN MATERNAL LYMPHOID TISSUE." In Pregnancy Proteins in Animals, edited by Jann Hau. De Gruyter, 1986. http://dx.doi.org/10.1515/9783110858167-035.

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Kirsch, Brian James, Shu-Jyuan Chang, Michael James Betenbaugh, and Anne Le. "Non-Hodgkin Lymphoma Metabolism." In The Heterogeneity of Cancer Metabolism. Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-65768-0_7.

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AbstractNon-Hodgkin lymphomas (NHLs) are a heterogeneous group of lymphoid neoplasms with different biological characteristics. About 90% of all lymphomas in the United States originate from B lymphocytes, while the remaining originate from T cells [1]. The treatment of NHLs depends on the neoplastic histology and stage of the tumor, which will indicate whether radiotherapy, chemotherapy, or a combination is the best suitable treatment [2]. The American Cancer Society describes the staging of lymphoma as follows: Stage I is lymphoma in a single node or area. Stage II is when that lymphoma has spread to another node or organ tissue. Stage III is when it has spread to lymph nodes on two sides of the diaphragm. Stage IV is when cancer has significantly spread to organs outside the lymph system. Radiation therapy is the traditional therapeutic route for localized follicular and mucosa-associated lymphomas. Chemotherapy is utilized for the treatment of large-cell lymphomas and high-grade lymphomas [2]. However, the treatment of indolent lymphomas remains problematic as the patients often have metastasis, for which no standard approach exists [2].
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Singh Chauhan, Vikram. "Vitamin D and the Immune System." In Vitamin D. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.97300.

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In the past few decades, various novel actions of vitamin D have been discovered. The mechanism of action of calcitriol or vitamin D is mediated by the Vitamin D receptor (VDR), a subfamily of nuclear receptors, which acts as a transcription factor in the target cells after formation of a heterodimer with the retinoid X receptor (RXR). As the VDR has been found in virtually all cell types, vitamin D exerts multiple actions on different tissues. Vitamin D has important immunomodulatory actions, which includes enhancement of the innate immune system and inhibition of the adaptative immune responses. These actions are associated with an increase in production of interleukin (IL)-4 by T helper (Th)-2 lymphocytes and the up-regulation of regulatory T lymphocytes. Vitamin D can regulate the immune responses in secondary lymphoid organs as well as in target organs through a number of mechanisms. Vitamin D inhibits the expression of APC cytokines, such as interleukin-1 (IL-1), IL-6, IL-12, and tissue necrosis factor- α (TNF-α) and decreases the expression of a set of major histocompatibility complex (MCH) class II cell surface proteins in macrophages. Vitamin D also inhibits B cell differentiation and antibody production. These actions reflect an important role of Vitamin D in balancing the immune system.
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Huhtaniemi, Ilpo, and Jorma Toppari. "Endocrine and Local Regulation of Testicular Hormone and Sperm Production." In Oxford Textbook of Endocrinology and Diabetes 3e, edited by John A. H. Wass, Wiebke Arlt, and Robert K. Semple. Oxford University Press, 2021. http://dx.doi.org/10.1093/med/9780198870197.003.0480.

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The testis has two main functions, that is, androgen production and spermatogenesis, and the key role in their endocrine regulation is played by the two pituitary gonadotrophins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH). LH stimulates Leydig cells of testicular interstitial tissue in the production of testosterone (T). T, secreted into the peripheral circulation, regulates the function of an array of androgen-responsive non-gonadal target tissues. Within the testis, T regulates indirectly spermatogenesis through stimulation of Sertoli cells in the seminiferous tubules. FSH promotes spermatogenesis, also indirectly, through actions on Sertoli cells. A plethora of local paracrine signals and metabolites between Sertoli and germ cells underlie the intricate regulatory mechanisms of spermatogenesis. This chapter summarizes the main hormonal regulation of the testis, that is, the hypothalamic–pituitary–testicular axis, and the main events in the process of spermatogenesis and its regulation.
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Torres, Isabel, Miguel Ángel López Casado, Teresa Palomeque, and Pedro Lorite. "Immune Checkpoints as a Novel Source for Diagnostic and Therapeutic Target in Celiac Disease." In Celiac Disease. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.96022.

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Celiac disease, as an autoimmune disorder, is a disease which appears in sensing and immune reaction responses to gluten. It has been confirmed that both genetic and environmental factors are involved. CD is strongly associated with the HLA alleles DQB1*02 (serological DQ2) or DQB1*0302 (serological DQ8). These HLA alleles are necessary but not sufficient for the development of CD and non-HLA risk genes also contribute to disease susceptibility. Several studies have identified linkage or association of CD with the 2q33 locus, a region harboring the candidate genes CD28, CTLA4 and ICOS, important immune checkpoints regulators of T-cell activity. Immune checkpoints are crucial to maintain self-tolerance and protect self-tissue from damage during an ongoing immune response.
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"Pathology." In Diagnosing and Managing Hashimoto’s Disease. IGI Global, 2020. http://dx.doi.org/10.4018/978-1-5225-9655-4.ch003.

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Grossly, thyroid enlargement in Hashimoto's thyroiditis (HT) is generally symmetrical, often with a characteristic conspicuous pyramidal lobe. The tissue involved by HT is pinkish-tan to frankly yellowish in color and tends to have a rubbery firmness. There is no necrosis or calcification. The capsule is intact and non-adherent to peri-thyroid structures. Microscopically, there is a diffuse process consisting of a combination of epithelial cell destruction, lymphoid cellular infiltration, and fibrosis. Lymphocytes are predominantly T-cells and plasma cells. Most infiltrating T-cells have α/β T-cell receptors. Gamma/delta T-cells are rare. Hashimoto's thyroiditis has been graded based on lymphocytic infiltration seen on cytology, into Grades 0-III, where Grade 0 means no lymphoid cells and Grade III severe lymphoid cell infiltration. Deposits of dense material representing IgG are found along the basement membrane on electron microscopy. This chapter explores the pathology of Hashimoto's disease.
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Conference papers on the topic "Non-lymphoid tissue regulatory t cells"

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Jukoski, Tayana Schultz, Talita Helen B. Gomig, Tamyres MIngorance Carvalho, Cicero Andrade Urban, and Enilze Maria Souza Fonseca Ribeiro. "IN SILICO AND PROTEOMICS APPROACHES SUGGEST UPREGULATION OF miR-146a-5p IN TNBC AND MODULATION OF CRITICAL PROTEINS." In Scientifc papers of XXIII Brazilian Breast Congress - 2021. Mastology, 2021. http://dx.doi.org/10.29289/259453942021v31s1051.

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Introduction: Breast cancer (BC) is the most common type of cancer after non-melanoma skin tumors among Brazilian women, with 61.61 cases estimated for 100 thousand women in 2020. New biomarkers, such as miRNAs and selected proteins, are essential in personalized medicine. Objectives: To evaluate the expression and possible role of miR-146a-5p in subtypes of BC. Methods: miRNAs selection was performed using in silico analysis from the TCGA (The Cancer Genome Atlas) database. Data from the miRNAs expression of 1,085 patients were accessed and compared among BC subtypes. After normalization, the
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Pannekoek, H., M. Linders, J. Keijer, H. Veerman, H. Van Heerikhuizen, and D. J. Loskutoff. "THE STRUCTURE OF THE HUMAN ENDOTHELIAL PLASMINOGEN ACTIVATOR INHIBITOR (PAI-1) GENE: NON-RANDOM POSITIONING OF INTRONS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644767.

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The endothelium plays a crucial role in the regulation of the fibrinolytic process, since it synthesizes and secretes tissue-type plasminogen activator (t-PA) as well as the fast-acting plasminogen activator inhibitor (PAI-1). Molecular cloning of full-length PAI-1 cDNA, employing a human endothelial cDNA expression library, and a subsequent determination of the complete nucleotide sequence, allowed a prediction of the amino-acid sequence of the PAI-1 glycoprotein. It was observed that the amino-acid sequence is significantly homologous to those of members of the serine protease inhibitor ("Se
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