Relevant bibliographies by topics / Non-invasive treatment

Academic literature on the topic 'Non-invasive treatment'

Author: Grafiati
Published: 1 June 2024

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Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Journal articles on the topic "Non-invasive treatment":

1

Lal, Sahu Ramji. "Non-Drug Non-Invasive Treatment in the Management of Neck Pain." Indian Journal of Trauma and Emergency Pediatrics 8, no. 2 (2016): 107–12. http://dx.doi.org/10.21088/ijtep.2348.9987.8216.12.

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Carlson, Robert H. "Treatment for Barrettʼs oesophagus: invasive or non-invasive?" Oncology Times UK 8, no. 7 (July 2011): 17–18. http://dx.doi.org/10.1097/01.otu.0000399896.06171.37.

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Kumar, Amit, and Piyush Mittal. "Invasive vs Non Invasive treatment in stenosing tenosynovitis." Indian Journal of Physiotherapy and Occupational Therapy - An International Journal 12, no. 1 (2018): 70. http://dx.doi.org/10.5958/0973-5674.2018.00013.8.

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Moisset, X., and J. P. Lefaucheur. "Non pharmacological treatment for neuropathic pain: Invasive and non-invasive cortical stimulation." Revue Neurologique 175, no. 1-2 (January 2019): 51–58. http://dx.doi.org/10.1016/j.neurol.2018.09.014.

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Tribulaitė, Martina, and Zita Gierasimovič. "Non-invasive treatment of skin problems." Slauga. Mokslas ir praktika 3, no. 6 (306) (June 27, 2022): 15–21. http://dx.doi.org/10.47458/slauga.2022.3.15.

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With age the structure of facial skin changes. Non-invasive procedures help maintain skin’s elasticity, the need for them exists in the 21st century too. Aim. Was to ascertain the effect of non-invasive procedures on facial skin problems. Research Methods. A qualitative investigation and oral survey were chosen. Two participants were chosen in the targeted selection: participant 1 (28 years old) was treated with the Darsonval apparatus; ultrasound procedures were chosen for participant 2 (56 years old). Results and Conlusions. Following the procedures, the number of acnes decreased on both sides of the face of participant 1, sebum secretion was partly regulated, a network of capillaries on the cheeks diminished visually, the condition of facial skin improved. The expected results were partly achieved. As to participant 2, mimic wrinkles, fine lines around the eyes and deeper wrinkles in the T zone were slightly reduced. Minimum results were achieved: a feeling of skin tension was removed, skin became softer, smoother, keratinisation reduced. Frequency of non-invasive procedures enabled the participants with skin problems to reach a positive result of skin changes, which was achieved faster in the case of participant 2.
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Elwes, GJ. "Phantom limb pain. Non-invasive treatment." Focus on Alternative and Complementary Therapies 2, no. 4 (June 14, 2010): 187. http://dx.doi.org/10.1111/j.2042-7166.1997.tb00709.x.

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Tillashayhov, Mirzagaleb Nigmatovich, Elena Vladimirovna Boyko, Ravshan Abdurasulovich Khashimov, and Nodir Mahammatkulovich Rakhimov. "Transurethral Resection Of En-Bloс Muscularis Non - Invasive Bladder Cancer." American Journal of Medical Sciences and Pharmaceutical Research 03, no. 06 (June 10, 2021): 82–86. http://dx.doi.org/10.37547/tajmspr/volume03issue06-13.

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The high recurrence rate of muscle noninvasive bladder cancer (BC) dictates the search for new methods of surgical treatment. The problem of bladder cancer (BC) treatment is very urgent in urology, because of high morbidity, difficulties in determining the optimal treatment tactics, necessity of long-term follow-up examinations, high recurrence rate and progression. Risk and progression criteria have been developed to identify groups of patients in need of closer follow-up, which can be quantified using risk calculators for recurrence and tumour progression. Although there are clear guidelines for the treatment of patients with bladder cancer, it is also believed that the rate of recurrence depends on the quality of the primary surgical procedure performed [1,2].
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Suen, Paulo J. C., and Andre R. Brunoni. "Non-invasive brain stimulation therapies." Revista de Medicina 98, no. 4 (August 30, 2019): 279–89. http://dx.doi.org/10.11606/issn.1679-9836.v98i4p279-289.

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Noninvasive brain stimulation therapies are a promising field for the development of new protocols for the treatment of neuropsychiatric disorders. They are based on the stimulation of neural networks with the intent of modeling their synaptic activity to adequate levels. For this, it is necessary to precisely determine which networks are related to which brain functions, and the normal activation level of each of these networks, so that it is possible to direct the stimulation to the affected networks in order to induce the desired effects. These relationships are under intense investigation by the scientific community, and will contribute to the advancement of treatments by neurostimulation, with the emergence of increasingly accurate and effective protocols for different disorders. Currently, the most used techniques are Transcranial Direct Current Stimulation and Transcranial Magnetic Stimulation, with the most common applications being for treating Major Depressive Disorder. The advancement of research in this field may determine new target networks for stimulation in the treatment of other disorders, extending the application of these techniques and also our knowledge about brain functioning.
9

Diehm, Curt, and Nicolas Diehm. "Non-Invasive Treatment of Critical Limb Ischemia." Current Drug Target -Cardiovascular & Hematological Disorders 4, no. 3 (September 1, 2004): 241–47. http://dx.doi.org/10.2174/1568006043336069.

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Wang, Yak-Nam, Andrew Brayman, Dan Leotta, Tatiana D. Khokhlova, Keith Chan, Wayne Monsky, and Thomas Matula. "Non-invasive treatment of abscesses by histotripsy." Journal of the Acoustical Society of America 146, no. 4 (October 2019): 2992. http://dx.doi.org/10.1121/1.5137357.

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Journal articles Dissertations / Theses Books

Dissertations / Theses on the topic "Non-invasive treatment":

1

Kitshoff, Adriaan Mynhardt. "Comparative biomechanics of two non-invasive mandibular fracture repair techniques in dogs." Diss., University of Pretoria, 2012. http://hdl.handle.net/2263/30897.

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Pérez, Trenard Diego Oswaldo. "Optimal control of non-invasive neuromodulation for the treatment of sleep apnea syndromes." Thesis, Rennes 1, 2018. http://www.theses.fr/2018REN1S014/document.

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Le syndrome d'apnée du sommeil (SAS) est une maladie multifactorielle caractérisée par des épisodes récurrents de pauses respiratoires ou des réductions significatives de l'amplitude respiratoire pendant le sommeil. Ces épisodes peuvent provoquer des réactions cardiorespiratoires aiguës; délétères à long terme. Plusieurs thérapies ont été proposées, étant la pression positive continue des voies respiratoires (CPAP) le traitement de référence. Malgré ces excellents résultats chez les patients symptomatiques, le taux de refus initial est de 15% et une adhésion à long terme est difficile à atteindre. Par conséquent, le développement de méthodes de traitement non invasives, avec une meilleure acceptabilité, reste d’une importance majeure. Dans ce contexte, l’hypothèse qui sous-tend ce travail est qu’une stimulation kinesthésique contrôlée, délivrée au cours de la phase précoce de l’apnée, peut réduire la durée des événements respiratoires et, par la suite, limiter les désaturations d’oxygène associées, par une activation contrôlée du réflexe de sursaut. La première partie de ce manuscrit est consacrée à la description d'un nouveau système (PASITHEA) de surveillance en temps réel et de neuromodulation thérapeutique, qui fonctionne comme un dispositif polyvalent de diagnostic et de traitement de SAS par stimulation kinesthésique. Les principales contributions de cette thèse se concentrent sur les aspects du traitement du signal et du contrôle de ce système, ainsi que sur l'électronique associée. Une autre contribution est liée à l'évaluation de ces méthodes et dispositifs par des protocoles cliniques spécifiques. Dans une deuxième partie, nous proposons une première méthode de contrôle On/Off optimale pour délivrer la stimulation, en utilisant comme variable de contrôle la sortie d'un détecteur d'événements respiratoires en temps réel. Lors de la détection d'un événement, une stratégie de stimulation unique avec amplitude de stimulation constante est appliquée, cette dernière a été mise en œuvre dans le cadre d'un premier protocole clinique dédié à l'évaluation de la réponse du patient au traitement. Les résultats ont montré que 75% des patients répondaient correctement au traitement en termes de durées des épisodes respiratoires. De plus, des diminutions significatives de la variabilité du SaO2 ont également été constatées lors de la mise en œuvre d'une nouvelle méthode d'analyse aiguë. Puisque nous avons supposé qu'une sélection inappropriée des patients pourrait expliquer l'absence de réponse observée chez 25% des patients. Nous avons proposé une méthode pour différencier les patients qui pourraient bénéficier de cette thérapie, basée sur l'estimation d'indices de variabilité cardiaque. Les résultats de ces analyses ont montré que l'efficacité de cette thérapie semble corrélée à un système nerveux autonome fonctionnel. Enfin, une méthode améliorée de contrôle en boucle fermée, intégrant des correcteurs proportionnels-dérivés (PD) couplés et simultanés a été proposée afin de modifier de façon adaptative l’amplitude de stimulation kinesthésique délivrée au patient par le système thérapeutique, en utilisant comme variables de contrôle des signaux physiologiques enregistrés en temps réel. Un deuxième protocole clinique visant à valider l'algorithme de contrôle de la stimulation kinesthésique adaptative spécifique au patient a été initié. Plusieurs améliorations ont été effectuées à la première version du système afin de permettre l'intégration du contrôleur proposé. Les résultats préliminaires de cette étude ont validé le fonctionnement de notre contrôleur et ont montré que notre système était capable de fournir une stimulation kinesthésique adaptative en fonction des réponses propres au patient. Une autre phase de cette étude, mettant en œuvre le contrôleur avec un ensemble des paramètres de contrôle présélectionnés, est actuellement en cours
Sleep apnea syndrome (SAS) is a multifactorial disease characterized by recurrent episodes of breathing pauses or significant reductions in respiratory amplitude during sleep. These episodes may provoke acute cardiorespiratory responses along with alterations of the sleep structure, which may be deleterious in the long term. Several therapies have been proposed for the treatment of SAS, being continuous positive airway pressure the gold standard treatment. Despite its excellent results in symptomatic patients, there is a 15% initial refusal rate and long term adherence is difficult to achieve in minimally symptomatic patients. Therefore, the development of non-invasive SAS treatment methods, with improved acceptability, is of major importance. The objective of this PhD thesis is to propose new signal processing and control methods of non-invasive neuromodulation for the treatment of SAS. The hypothesis underlying this work is that bursts of kinesthetic stimulation delivered during the early phase of apneas or hypopneas may elicit a controlled startle response that can activate sub-cortical centers controlling upper airways muscles and the autonomic nervous system, stopping respiratory events without generating a cortical arousal. In this context, the first part of this manuscript is dedicated to the description of a novel real-time monitoring and therapeutic neuromodulation system, which functions as a multi-purpose device for SAS diagnosis and treatment through kinesthetic stimulation. This system has been developed in the framework of an ANR TecSan project led by our laboratory, with the participation of Sorin CRM SAS. The main contributions in this thesis are focused on the signal processing and control aspects of this system, as well as the electronics associated. Another contribution is related to the evaluation of these methods and devices through specific clinical protocols. In a second part, we propose a first optimal On/Off control method for delivering kinesthetic stimulation, using as control variable the output of a real-time respiratory event detector. A unique stimulation strategy where a constant stimulation amplitude is applied upon event detention was implemented in a first clinical protocol, dedicated to assessing the patient response to therapy. Results showed that 75% of the patients responded correctly to therapy, showing statistically significant reductions in respiratory event durations. Also, significant decreases in the SaO2 variability were also found when implementing a novel acute analysis method. Since we hypothesized that inappropriate patient selection could explain the observed lack of response in 25% of patients, we proposed a method to differentiate patients who could benefit from this therapy based on the estimation of complexity-based indexes of heart rate variability. Results of these analyses showed that the effectiveness of this therapy seems correlated to a functional autonomic nervous system. Finally, an improved closed-loop control method integrating concurrent, coupled proportional-derivative (PD) controllers in order to adaptively change the kinesthetic stimulation was proposed. It uses as control variables three physiological signals recorded in real-time: Nasal pressure, oxygen saturation and the electrocardiogram signal. A second clinical protocol with the main objective of validating the control algorithm for patient-specific adaptive kinesthetic stimulation was launched. Several improvements to the first version of the system were developed to allow the integration of the proposed controller. Preliminary results from the first phase of this study validated the proposed controller operation and showed that the controller was able to provide adaptive kinesthetic stimulation in function of the patient-specific responses. A second phase of this study implementing the proposed controller and the set of the selected control parameters from the first phase is currently ongoing
3

Higgins, Jennifer Ann. "The impact of chemoprevention on treatment regimens for non-muscle invasive bladder cancer." Thesis, University of Leicester, 2011. http://hdl.handle.net/2381/9527.

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Chemoprevention is becoming a highly promising approach to lowering the incidence of cancers. There is, however, insufficient data to determine whether these agents are safe to be used alongside established treatment regimens such as chemotherapy. Non-muscle invasive bladder cancer is readily treatable with surgery (TURBT), yet there is a high rate of recurrence (~60%), 20-30% of patients recurring with the muscle invasive form of the disease, making it a good candidate for chemopreventive intervention. Anthocyanins are one example of dietary compounds currently under investigation as chemopreventive agents. They have been found excreted in the urine of mice at levels capable of causing 50% growth inhibition in cancer cell lines, making them potential bladder cancer chemopreventive agents. Mirtoselect, a standardised bilberry extract containing a mixture of 15 different anthocyanins, was investigated in vitro as a potential chemopreventive agent for bladder cancer alongside chemotherapeutic agent mitomycin C (MMC). Mirtoselect itself was found to inhibit cell survival and growth, causing significant a decrease in clonogenic cell survival, as well as causing an increase in apoptosis in two of the bladder cancer cell lines investigated. In combined studies mirtoselect pre-treatment did not inhibit the effects of MMC in measures of growth, cell survival, apoptosis, cell cycle distribution or DNA damage. In fact, there was a mirtoselect dependent increase in MMC-induced crosslinks, an enhancement of MMCs anti-proliferative effects at low concentrations of mirtoselect and in some instances apoptosis was greater than additive. Furthermore mirtoselect was shown to enhance the DNA damaging effects of radiation. Mirtoselect itself appears to be a good chemopreventive candidate for non-muscle invasive bladder cancer. In combination it does not appear to interfere with the cytotoxic actions of MMC, potentially enhancing its effects, and could also provide a therapeutic advantage in radiotherapy, therefore warranting further investigation for use in clinic.
4

O'Connell, Neil Edward. "Non-invasive brain stimulation as a novel approach to the treatment of chronic non-specific low back pain." Thesis, Brunel University, 2012. http://bura.brunel.ac.uk/handle/2438/7237.

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Chronic non-specific low back pain (CNSLBP) is a widespread but poorly understood condition that places a substantial burden on the sufferer, health services and the wider economy. Existing approaches to management do not demonstrate impressive levels of effectiveness. There is growing evidence that CNSLBP is associated with significant alterations in central nervous system (CNS) structure and function, suggesting a possible role for the brain in the aetiology of the condition, and presenting a case for novel therapies which aim to treat CNSLBP by affecting brain function. One such potential therapeutic approach is non-invasive brain stimulation (NIBS). Following a literature review discussing the epidemiology and management of low back pain, the evidence for altered CNS function and the potential role of brain stimulation in CNSLBP and chronic pain generally this thesis includes 3 original scientific studies: (i) A Cochrane systematic review of the effectiveness of NIBS techniques for the treatment of chronic pain; (ii) A randomised double-blind exploratory study of transcranial direct current stimulation of the motor cortex in the treatment of CNSLBP; (iii) Is blinding to the stimulation condition maintained in trials comparing 2mA tDCS with sham stimulation? A randomised cross-over study. Results: There is limited existing evidence that some forms of NIBS may have a beneficial effect on chronic pain, though caution is warranted. Exploratory data from study 2 is not suggestive that tDCS to the motor cortex is effective for treating CNSLBP. Commonly used sham controls in trials of tDCS do not ensure adequate blinding, and so introduce a potential source of bias to the existing evidence base. Conclusion: Further research is required to establish the value of NIBS as a treatment for chronic pain and CNSLBP. Future research in tDCS will need to develop and employ fully validated sham controls to ensure adequate blinding. NIBS cannot currently be recommended for the treatment of CNSLBP.
5

Pakdaman, Afsaneh. "Dental Student Management Of Non-Invasive Intervention For Dental Caries." Thesis, The University of Sydney, 2006. http://hdl.handle.net/2123/4961.

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Willson, Grant Neville. "Nocturnal non-invasive ventilation for the treatment of Cheyne-Stokes respiration in chronic heart failure." Thesis, The University of Sydney, 2004. https://hdl.handle.net/2123/27912.

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This thesis has investigated the efficacy of non-invasive ventilation in subjects with congestive heart failure (CHF) and Cheyne—Stokes respiration (CSR). The effect of this therapy on sleep, breathing and haemodynamic variables has been examined. This thesis also describes the morphology and magnitude of the blood pressure (BP) and heart rate (HR) oscillations associated with CSR and elucidates contributing factors to the changes observed. Chapter 1 - literature review - outlines the presentation and treatment of CSR in patients with CHF. Cheyne-Stokes respiration is described with particular emphasis on the polysomnographic features and haemodynamic consequences of this breathing pattern. The mechanisms postulated for the genesis of CSR are reviewed. The prevalence and consequences of CSR are discussed, highlighting the clinical features and their effects on prognosis. The proposed treatments are considered, with attention being paid to the mechanisms of action, the effect on sleep, breathing, haemodynamics and the clinical utility of each therapy. Special emphasis is placed on oxygen and continuous positive airway pressure (CPAP) therapy. It is proposed that given the lack of universal acceptance of any one treatment modality, the role of new therapies that emulate the positive effects of current treatments, warrant further investigation. A review of noninvasive ventilation including a survey of its historical use, methodological considerations, physiological consequences and clinical applications has been undertaken.
7

Wang, Xusheng. "Ultrasonic Generator for Surgical Applications and Non-invasive Cancer Treatment by High Intensity Focused Ultrasound." Thesis, Université Paris-Saclay (ComUE), 2016. http://www.theses.fr/2016SACLS052/document.

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La technique de haute intensité ultrasons focalisés (HIFU) est maintenant largement utilisée pour le traitement du cancer, grâce à son avantage non-invasif. Dans un système de HIFU, une matrice de transducteurs à ultrasons est pilotée en phase pour produire un faisceau focalisé d'ultrasons (1M ~ 10 MHz) dans une petite zone de l'emplacement de la cible sur le cancer dans le corps. La plupart des systèmes HIFU sont guidées par imagerie par résonance magnétique (IRM) dans de nos jours. Dans cette étude de doctorat, un amplificateur de puissance de classe D en demi-pont et un système d'accord automatique d'impédance sont proposés. Tous deux circuits proposés sont compatibles avec le système IRM. L'amplificateur de puissance proposé a été réalisé par un circuit imprimé (PCB) avec des composants discrets. Selon les résultats du test, il a rendement de conversion en puissance de 82% pour une puissance de sortie conçue de 1,25W à une fréquence de travail de 3MHz. Le système d'accord automatique d'impédance proposé a été conçu en deux versions: une version en PCB et une version en circuit intégré (IC). Contrairement aux systèmes d'accord automatique proposés dans la littérature, il n'y a pas besoin de l'unité de microcontrôleur (MCU) ou de l'ordinateur dans la conception proposée. D'ailleurs, sans l'aide de composants magnétiques volumineux, ce système d'auto-réglage est entièrement compatible avec l'équipement IRM. La version en PCB a été conçue pour vérifier le principe du système proposé, et il est également utilisé pour guider à la conception du circuit intégré. La réalisation en PCB occupe une surface de 110cm². Les résultats des tests ont confirmé la performance attendue. Le système d'auto-tuning proposé peut parfaitement annuler l'impédance imaginaire du transducteur, et il peut également compenser l'impédance de la dérive causée par les variations inévitables (variation de température, dispersion technique, etc.). La conception du système d'auto-réglage en circuit intégré a été réalisé avec une technologie CMOS (C35B4C3) fournies par Austrian Micro Systems (AMS). La surface occupée par le circuit intégré est seulement de 0,42mm². Le circuit intégré conçu est capable de fonctionner à une large gamme de fréquence tout en conservant une consommation d'énergie très faible (137 mW). D'après les résultats de la simulation, le rendement de puissance de ce circuit peut être amélioré jusqu'à 20% comparant à celui utilisant le réseau d'accord statique
High intensity focused ultrasound (HIFU) technology is now broadly used for cancer treatment, thanks to its non-invasive property. In a HIFU system, a phased array of ultrasonic transducers is utilized to generate a focused beam of ultrasound (1M~10MHz) into a small area of the cancer target within the body. Most HIFU systems are guided by magnetic resonance imaging (MRI) in nowadays. In this PhD study, a half-bridge class D power amplifier and an automatic impedance tuning system are proposed. Both the class D power amplifier and the auto-tuning system are compatible with MRI system. The proposed power amplifier is implemented by a printed circuit board (PCB) circuit with discrete components. According to the test results, it has a power efficiency of 82% designed for an output power of 3W at 1.25 MHz working frequency. The proposed automatic impedance tuning system has been designed in two versions: a PCB version and an integrated circuit (IC) version. Unlike the typical auto-impedance tuning networks, there is no need of microprogrammed control unit (MCU) or computer in the proposed design. Besides, without using bulky magnetic components, this auto-tuning system is completely compatible with MRI equipment. The PCB version was designed to verify the principle of the proposed automatic impedance tuning system, and it is also used to help the design of the integrated circuit. The PCB realization occupies a surface of 110cm². The test results confirmed the expected performance. The proposed auto-tuning system can perfectly cancel the imaginary impedance of the transducer, and it can also compensate the impedance drifting caused by unavoidable variations (temperature variation, technical dispersion, etc.). The IC design of the auto-tuning system is realized in a CMOS process (C35B4C3) provided by Austrian Micro Systems (AMS). The die area of the integrated circuit is only 0.42mm². This circuit design can provide a wide working frequency range while keeping a very low power consumption (137 mW). According to the simulation results, the power efficiency can be improved can up to 20% by using this auto-tuning circuit compared with that using the static tuning network
8

Pandey, Rakhi. "Development of a nanoparticulate formulation of docetaxel for the treatment of non-muscle-invasive bladder cancer." Thesis, University of British Columbia, 2014. http://hdl.handle.net/2429/50506.

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Approximately 70-85% of bladder cancer patients present with non-muscle invasive bladder cancer (NMIBC). These patients are usually treated by surgical resection of bladder tumours followed by the intravesical administration of anticancer drugs such as mitomycin C (MMC), doxorubicin or gemcitabine. However the recurrence rate after 5 years remains high (70%) so that the development of more effective chemotherapeutic strategies is essential. We have previously shown that hyperbranched polyglycerol (HPG-C₈/₁₀-MePEG-NH₂) nanoparticulate carriers of docetaxel (DTX) offered an improved and effective formulation of the drug for intravesical delivery in mice. The present work describes the effect of concentration and exposure times of three HPG-C₈/₁₀-MePEG-NH₂’s with increasing degrees of amineation on ex vivo porcine bladder tissue morphology and the tissue depth uptake of DTX. The results demonstrated the exfoliation of porcine bladder tissues in a time and concentration-dependent manner. Exfoliation and DTX uptake was significantly enhanced upon treatment with medium or high-density HPG-C₈/₁₀-MePEG-NH₂’s, as compared to a commercially available DTX/polysorbate 80 formulation. Further studies on the local effect of the chemotherapeutic agents MMC, doxorubicin and gemcitabine, on ex vivo porcine bladder tissue showed that these drugs all caused exfoliation of urothelium and were well taken up by the bladder tissue with no additional effect of HPG-C₈/₁₀-MePEG-NH₂ pre-treatment. The exfoliating effect of these three drugs was shown to enhance the bladder tissue uptake of paclitaxel (PTX) or DTX when the bladder was exposed to combinations of taxanes with either MMC, doxorubicin or gemcitabine. Generally, the exfoliation effect of HPG-C₈/₁₀-MePEG-NH₂’s, MMC, doxorubicin and gemcitabine is attributed to an interaction of the positively charged amine groups on all these agents with the negatively charged mucosal surface. This binding may modulate tight junction protein function followed by exfoliation of the protective urothelial layer so that drugs may penetrate the exposed underlying tissue. In conclusion this thesis supports a novel role of DTX loaded-HPG-C₈/₁₀-MePEG-NH₂ nanoparticles as an improved drug delivery vehicle for the potential chemotherapeutic treatment of bladder cancer. Additionally, data suggests promising strategies for intravesical combination drug therapies, to enhance the uptake of taxanes with potential additive therapeutic effects for improved efficacy in the treatment of NMIBC.
Pharmaceutical Sciences, Faculty of
Graduate
9

Berkius, Johan. "Intensive care in chronic obstructive pulmonary disease : treatment with non-invasive ventilation and long-term outcome." Doctoral thesis, Linköpings universitet, Avdelningen för kardiovaskulär medicin, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-100738.

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Background: Chronic obstructive pulmonary disease (COPD) is a major cause of chronic morbidity and mortality throughout the world. When we began this project our knowledge about the outcome of COPD patients admitted to the ICU in Sweden was scarce. Aims: To investigate the characteristics, survival and health-related quality of life (HRQL) of COPD patients admitted to Swedish ICUs. To investigate how ICU personnel decide whether to use invasive or non-invasive ventilatory treatment (NIV) of the newly admitted COPD patient in need of ventilatory support. To investigate outcome according to mode of ventilation. Material and methods: Detailed data, including HRQL during recovery, from COPD patients admitted to ICUs that participated in the Swedish intensive care registry were analysed. A questionnaire was distributed to personnel in 6 of the participating ICUs in order to define factors deemed important in making the choice between invasive and non-invasive ventilation immediately after admission. The answers were analysed. Results: The proportion of COPD patients admitted to Swedish ICUs in need of ventilatory support is 1.3-1.6 % of all admissions. The patients are around 70 years-old and are severely ill on admission, with high respiratory rates and most have life-threatening disturbances in their acid-base balance and blood gases. There are more women than men. The short- and long-term mortality is high despite intensive care treatment. The majority of patients are treated with NIV. The length of stay on the ICU is shorter when NIV is used. The choice between NIV and invasive ventilation in these patients may be irrational. It is guided by current guidelines, but other non-patient-related factors seem to influence this decision. NIV seems to be preferable to invasive ventilation at admission, not only according to short-term benefits but also to long-term survival. Failure of NIV followed by invasive ventilation does not have a poorer prognosis than directly employing invasive ventilation. The health-related quality of life of COPD patients after treatment on Swedish ICUs is lower than in the general population. However it does not decline between 6 and 24 months after ICU discharge. After 24 months the HRQL is quite similar to that of COPD patients not treated on the ICU. Conclusions: COPD patients in need of ventilatory support admitted to Swedish ICUs are severely ill on admission, and their short- and long-term mortality is high despite ICU care and ventilatory treatment. Non-invasive ventilation should be the first line treatment on admission. NIV has short- and long-term benefits compared to invasive ventilation, without increasing mortality risk in case of failure. After discharge from the ICU and recovery, the HRQL of COPD patients is lower than in the general population, but comparable to COPD patients not treated on the ICU.
10

Bour, Pierre. "Non-invasive treatment of cardiac arrhythmias by high-intensity focussed ultrasound guided by magnetic resonance imaging." Thesis, Bordeaux, 2017. http://www.theses.fr/2017BORD0731/document.

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Les ultrasons focalisés de hautes intensités ont la capacité de déposer de l'énergie ultrasonore localement et de façon non invasive dans les tissus biologiques. Il est possible d'exploiter les effets mécaniques et/ou thermiques en fonction des paramètres ultrasonores utilisés. Guidée par un système d'Imagerie de Résonance Magnétique, cette technologie se voit dotée d'une modalité de planification et le suivi en temps réel de la procédure. Les applications actuelles des ultrasons focalisés guidés par IRM sont sur des organes fixes, notamment le cerveau et l'os ou le fibrome utérin. Dans le cas du cœur, d'une part la présence de mouvements cardiaques et respiratoires constitue une difficulté importante, tant pour le traitement ultrasonore (balistique) que pour l'IRM de température (artéfacts sur les images). D'autre part, la cage thoracique joue le rôle de barrière pour la propagation des ultrasons. Dans ce travail de thèse, un ensemble de techniques nouvelles pour l'ablation et la stimulation cardiaque non invasive par ultrasons focalisés guidés par IRM a été développé. Une première étude montre la faisabilité technique de contrôler le rythme cardiaque par des impulsions ultrasonores brèves dirigées vers le myocarde. L'influence des paramètres des impulsions a été étudiée quantitativement sur cœur isolé battant puis in vivo sur un modèle préclinique. Pour cela, un dispositif original a été développé. Une seconde étude présente de nouvelles méthodes rapides d'IRM permettant de cartographier simultanément la température et le déplacement local induit par les ultrasons focalisés. La méthode est validée sur le foie sur un modèle préclinique, et démontre qu'il est possible de corréler la dose thermique obtenue par thermométrie IRM à un changement des propriétés mécaniques des tissus traités mesurés simultanément. Une troisième étude a consisté à développer une technique de mesure de position de la cible en 3D temps réel par quelques éléments de l'émetteur ultrasonore opérant en réception. Cette mesure permet de corriger dynamiquement la position du foyer ultrasonore pour maximiser le dépôt d'énergie au point ciblé, le tout monitoré par thermométrie IRM temps réel à une cadence de 10 images par seconde. Là encore, une validation préclinique est présentée. Ce travail de thèse propose donc des avancées importantes pour lever les verrous actuels de la technologie permettant d'envisager des traitements non invasifs des pathologies cardiaques par voie non invasive, le tout guidé par IRM en temps réel
High intensity focused ultrasound has the ability to deposit ultrasonic energy locally and non-invasively into biological tissues. It is possible to exploit the mechanical and/or thermal effects according to the ultrasonic parameters used. Guided by a Magnetic Resonance Imaging (MRI) scanner, this technology is equipped with a planning modality and real-time monitoring of the procedure. As of now, applications of MRI-guided focused ultrasound are on fixed organs, including brain and bone or uterine fibroid. For the heart, the presence of cardiac and respiratory movements constitutes an important difficulty, both for the ultrasonic (ballistic) treatment and for the temperature monitoring under MRI (artefacts on images). In addition, the rib cage acts as a barrier for the propagation of ultrasounds. In this thesis work, a set of new technological development have been developed for ablation and non-invasive cardiac stimulation using focused MRI-guided ultrasound. A first study shows the technical feasibility of controlling heart rhythm by short ultrasound pulses targeted to the myocardium. The influence of the parameters of the pulses (duration, amplitude, emission time in the cardiac cycle) were studied quantitatively on isolated beating heart then in vivo on a preclinical model. For this, an original device was developed. A second study presents new rapid MRI methods for simultaneously mapping the temperature and local displacement induced by focused ultrasound. The method is validated on the liver on a preclinical model and demonstrates that it is possible to correlate the thermal dose obtained by MR-thermometry with a change in the mechanical properties of the treated tissues measured simultaneously. A third study consisted in developing a technique for measuring the position of the target in 3D real-time using some elements of the ultrasonic transmitter as receivers. This measure allows to dynamically correct the position of the ultrasonic focus to maximize energy deposition at the targeted point. In addition, we monitored in real-time the procedure using MR-thermometry at a rate of 10 images per second. Here again a preclinical validation is presented. This thesis work proposes important advances to remove the current locks of the technology allowing to envision noninvasive treatments of cardiac pathologies, all guided by MRI in real-time
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Books on the topic "Non-invasive treatment":

1

K, Simonds Anita, ed. Non-invasive respiratory support. London: Chapman & Hall Medical, 1996.

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Klicpera, Martin. Chronic aortic regurgitation: Prognostic parameters for patients with chronic aortic regurgitation undergoing aortic valve replacement : value of invasive and non-invasive methods and pharmacological interventions (systemic vasodilation). Wien: Facultas Universitätsverlag, 1985.

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Baker-Price, Laura. Trans-cerebral magnetic (TCM) therapy: An effective and non-invasive treatment for depression and epileptic spectrum disorder (ESD) following brain trauma. Sudbury, Ont: Laurentian University, School of Graduate Studies, 2005.

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Simonds, Anita K. Non-Invasive Respiratory Support. Taylor & Francis Group, 2007.

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Masip, Josep, Kenneth Planas, and Arantxa Mas. Non-invasive ventilation. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199687039.003.0025.

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During the last 25 years, the use of non-invasive ventilation has grown substantially. Non-invasive ventilation refers to the delivery of positive pressure to the lungs without endotracheal intubation and plays a significant role in the treatment of patients with acute respiratory failure and in the domiciliary management of some chronic respiratory and sleep disorders. In the intensive and acute care setting, the primary aim of non-invasive ventilation is to avoid intubation, and it is mainly used in patients with chronic obstructive pulmonary disease exacerbations, acute cardiogenic pulmonary oedema, or in the context of weaning, situations in which a reduction in mortality has been demonstrated. The principal techniques are continuous positive airway pressure and bilevel pressure support ventilation. Whereas non-invasive pressure support ventilation requires a ventilator, continuous positive airway pressure is a simpler technique that can be easily used in non-equipped areas such as the pre-hospital setting. The success of non-invasive ventilation is related to the adequate timing and selection of patients, as well as the appropriate use of interfaces, the synchrony of patient-ventilator, and the fine-tuning of the ventilator.
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Masip, Josep, Kenneth Planas, and Arantxa Mas. Non-invasive ventilation. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199687039.003.0025_update_001.

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During the last 25 years, the use of non-invasive ventilation has grown substantially. Non-invasive ventilation refers to the delivery of positive pressure to the lungs without endotracheal intubation and plays a significant role in the treatment of patients with acute respiratory failure and in the domiciliary management of some chronic respiratory and sleep disorders. In the intensive and acute care setting, the primary aim of non-invasive ventilation is to avoid intubation, and it is mainly used in patients with chronic obstructive pulmonary disease exacerbations, acute cardiogenic pulmonary oedema, or in the context of weaning, situations in which a reduction in mortality has been demonstrated. The principal techniques are continuous positive airway pressure and bilevel pressure support ventilation. Whereas non-invasive pressure support ventilation requires a ventilator, continuous positive airway pressure is a simpler technique that can be easily used in non-equipped areas such as the pre-hospital setting. The success of non-invasive ventilation is related to the adequate timing and selection of patients, as well as the appropriate use of interfaces, the synchrony of patient-ventilator, and the fine-tuning of the ventilator.
7

Masip, Josep, Kenneth Planas, and Arantxa Mas. Non-invasive ventilation. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199687039.003.0025_update_002.

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During the last 25 years, the use of non-invasive ventilation has grown substantially. Non-invasive ventilation refers to the delivery of positive pressure to the lungs without endotracheal intubation and plays a significant role in the treatment of patients with acute respiratory failure and in the domiciliary management of some chronic respiratory and sleep disorders. In the intensive and acute care setting, the primary aim of non-invasive ventilation is to avoid intubation, and it is mainly used in patients with chronic obstructive pulmonary disease exacerbations, acute cardiogenic pulmonary oedema, or in the context of weaning, situations in which a reduction in mortality has been demonstrated. The principal techniques are continuous positive airway pressure and bilevel pressure support ventilation. Whereas non-invasive pressure support ventilation requires a ventilator, continuous positive airway pressure is a simpler technique that can be easily used in non-equipped areas such as the pre-hospital setting. The success of non-invasive ventilation is related to the adequate timing and selection of patients, as well as the appropriate use of interfaces, the synchrony of patient-ventilator, and the fine-tuning of the ventilator.
8

Masip, Josep, Kenneth Planas, and Arantxa Mas. Non-invasive ventilation. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199687039.003.0025_update_003.

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During the last 25 years, the use of non-invasive ventilation has grown substantially. Non-invasive ventilation refers to the delivery of positive pressure to the lungs without endotracheal intubation and plays a significant role in the treatment of patients with acute respiratory failure and in the domiciliary management of some chronic respiratory and sleep disorders. In the intensive and acute care setting, the primary aim of non-invasive ventilation is to avoid intubation, and it is mainly used in patients with chronic obstructive pulmonary disease exacerbations, acute cardiogenic pulmonary oedema, immunocompromised or in the context of weaning, situations in which a reduction in mortality has been demonstrated. The principal techniques are continuous positive airway pressure, bilevel pressure support ventilation and more recently, high flow nasal cannula. Whereas non-invasive pressure support ventilation requires a ventilator, the other two techniques are simpler and can be easily used in non-equipped areas by less experienced teams, including the pre-hospital setting. The success of non-invasive ventilation is related to an adequate timing, proper selection of patients and interfaces, close monitoring as well as the achievement of a good adaptation to patients’ demand.
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Simonds, Anita K. Non-Invasive Respiratory Support: A Practical Handbook. 2nd ed. A Hodder Arnold Publication, 2001.

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Bard, Robert L. Prostate Cancer Decoded: Non-Invasive Breakthrough Treatments. Morgan James Publishing, 2007.

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Book chapters on the topic "Non-invasive treatment":

1

Mann, Charles V. "Non-invasive Therapy." In Surgical Treatment of Haemorrhoids, 43–49. London: Springer London, 2002. http://dx.doi.org/10.1007/978-1-4471-3727-6_6.

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Nava, Stefano, and Francesco Fanfulla. "When to Start (or Not) Ventilation Treatment." In Non Invasive Artificial Ventilation, 21–27. Milano: Springer Milan, 2013. http://dx.doi.org/10.1007/978-88-470-5526-1_5.

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Bergfeld, Isidoor O., Eva Dijkstra, Ilse Graat, Pelle de Koning, Bastijn J. G. van den Boom, Tara Arbab, Nienke Vulink, Damiaan Denys, Ingo Willuhn, and Roel J. T. Mocking. "Invasive and Non-invasive Neurostimulation for OCD." In The Neurobiology and Treatment of OCD: Accelerating Progress, 399–436. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/7854_2020_206.

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Nava, Stefano, and Francesco Fanfulla. "NIV in the Treatment of Acute Respiratory Failure: Emerging Indications." In Non Invasive Artificial Ventilation, 91–98. Milano: Springer Milan, 2013. http://dx.doi.org/10.1007/978-88-470-5526-1_12.

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Nava, Stefano, and Francesco Fanfulla. "NIV in the Treatment of Acute Respiratory Failure: Controversial Indications." In Non Invasive Artificial Ventilation, 99–105. Milano: Springer Milan, 2013. http://dx.doi.org/10.1007/978-88-470-5526-1_13.

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Nava, Stefano, and Francesco Fanfulla. "NIV in the Treatment of Acute Respiratory Failure: The Magnificent Five." In Non Invasive Artificial Ventilation, 79–89. Milano: Springer Milan, 2013. http://dx.doi.org/10.1007/978-88-470-5526-1_11.

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Goonewardene, Sanchia S., Raj Persad, Hanif Motiwala, and David Albala. "Definitive Treatment in NMIBC." In Management of Non-Muscle Invasive Bladder Cancer, 123–24. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-28646-0_23.

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Roshan, Rahul, and Sanjeev Singhal. "Non Invasive Ventilation Asynchrony: Diagnosis and Treatment." In Noninvasive Mechanical Ventilation, 153–61. Cham: Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-031-28963-7_15.

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Earl, David C., Steven A. Lopez, and Lee K. Brown. "Pediatric Non-invasive Ventilation: Non-invasive Ventilation Treatment in a Pediatric Patient with Catathrenia." In Teaching Pearls in Noninvasive Mechanical Ventilation, 545–50. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-71298-3_62.

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Fallat, R. J., F. H. Norris, D. Holden, K. Kandal, and P. C. Roggero. "Respiratory Monitoring and Treatment: Objective Treatments Using Non-Invasive Measurements." In Amyotrophic Lateral Sclerosis, 191–200. Boston, MA: Springer US, 1987. http://dx.doi.org/10.1007/978-1-4684-5302-7_31.

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Conference papers on the topic "Non-invasive treatment":

1

Petrenko, Timur, Vladimir Kublanov, Konstantin Retyunskiy, and Roman Sherstobitov. "Possibilities of Applying Non-invasive Multichannel Electrical Stimulation Technology for Treatment Neuropsychiatric Diseases." In Special Session on Non-invasive Diagnosis and Neuro-stimulation in Neurorehabilitation Tasks. SCITEPRESS - Science and Technology Publications, 2020. http://dx.doi.org/10.5220/0009377304210426.

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Petrenko, Timur, Vladimir Kublanov, Konstantin Retyunskiy, and Roman Sherstobitov. "Possibilities of Applying Non-invasive Multichannel Electrical Stimulation Technology for Treatment Neuropsychiatric Diseases." In Special Session on Non-invasive Diagnosis and Neuro-stimulation in Neurorehabilitation Tasks. SCITEPRESS - Science and Technology Publications, 2020. http://dx.doi.org/10.5220/0009377300002513.

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Masclans, Joan R., Marcos Perez, Jordi Almirall, Leonardo Lorente, Asunción Marques, Lorenzo Socias, Loreto Viadur, and Jordi Rello. "Early Non-Invasive Ventilation Treatment For Severe Influenza Pneumonia." In American Thoracic Society 2012 International Conference, May 18-23, 2012 • San Francisco, California. American Thoracic Society, 2012. http://dx.doi.org/10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a3112.

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Kublanov, Vladimir, Yan Kazakov, and Anton Dolganov. "Machine Learning Possibilities for Evaluation of Arterial Hypertension Treatment Efficiency in Case Study." In Special Session on Non-invasive Diagnosis and Neuro-stimulation in Neurorehabilitation Tasks. SCITEPRESS - Science and Technology Publications, 2020. http://dx.doi.org/10.5220/0009372004110416.

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Kublanov, Vladimir, Yan Kazakov, and Anton Dolganov. "Machine Learning Possibilities for Evaluation of Arterial Hypertension Treatment Efficiency in Case Study." In Special Session on Non-invasive Diagnosis and Neuro-stimulation in Neurorehabilitation Tasks. SCITEPRESS - Science and Technology Publications, 2020. http://dx.doi.org/10.5220/0009372000002513.

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Koyama, Takuya, Saiko Kino, and Yuji Matsuura. "Non-invasive blood glucose measurement using fixed-wavelength quantum cascade lasers." In Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications XIX, edited by Israel Gannot. SPIE, 2019. http://dx.doi.org/10.1117/12.2508200.

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ten Cate, J. W., M. V. Huisman, and H. R. Buller. "DIAGNOSIS OF DEEP VENOUS THROMBOSIS: NON-INVASIVE VS INVASIVE DIAGNOSTIC PROCEDURES." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1642967.

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The clinical diagnosis of deep vein thrombosis (DVT) in symptomatic patients is unreliable. The need for objective diagnostic tests is widely acknowledged. Contrast venography in experienced hands is considered to be the reference method. This method is invasive, uncomfortable to the patient, not easily repeatable and expensive.For this reason several non-invasive tests have been developed and evaluated recently. Of the non-invasive tests impedance plethysmography (IPG) has been thoroughly evaluated in properly designed prospective clinical trials. Serial IPG in symptomatic outpatients is safe and effective. It was shown in longterm follow-up that anticoagulant treatment could be safely withheld in over 500 patients with repeatedly normal IPG (0.3-0.6% recurrence DVT). The specificity for proximal DVT was 92%. The feasability of IPG in symptomatic outpatients was over 95%. The safety of withholding anticoagulant treatment in symptomatic inpatients with a serial normal IPG is an unresolved issue. Preliminary results show that a similar sensitivity might be obtained in inpatients, however, the feasability was lower (87%).Doppler ultrasound has been studied extensively, however, there is a great variation in reported sensitivity for proximal DVT due to the lack of objective diagnostic criteria and the safety of withholding anticoagulant treatment in patients with serial normal Doppler tests results is not es tablished.strain gauge plethysmography has not been evaluated properly and therefore awaits further studies. 125I-fibrinogen legscanning has been shown to be sensitive for calf vein thrombosis (over 90%). In combination with IPG this method is a safe and effective alternative to venography.Radionuclide phlebography has never been evaluated in prospective clinical trials in a broad spectrum of symptomatic patients, and can therefore not be recommended for routine use.It is concluded that presently the management of patients with clinically suspected DVT should be performed with the use of serial IPG, IPG in combination with 125I—fibrinogen legscanning or contrast venog raphy.
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Lepekhina, A., M. Pospelova, G. Trufanov, T. Alekseeva, D. Iskhakov, T. Bukkieva, D. Chegina, N. Semibratov, B. Litvincev, and Y. Tsarevskaya. "Analysis of Functional Connectivity When using Complementary Methods of Treatment in Patients with Asymptomatic Carotid Stenosis." In Special Session on Non-invasive Diagnosis and Neuro-stimulation in Neurorehabilitation Tasks. SCITEPRESS - Science and Technology Publications, 2020. http://dx.doi.org/10.5220/0008953603730378.

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Lepekhina, A., M. Pospelova, G. Trufanov, T. Alekseeva, D. Iskhakov, T. Bukkieva, D. Chegina, N. Semibratov, B. Litvincev, and Y. Tsarevskaya. "Analysis of Functional Connectivity When using Complementary Methods of Treatment in Patients with Asymptomatic Carotid Stenosis." In Special Session on Non-invasive Diagnosis and Neuro-stimulation in Neurorehabilitation Tasks. SCITEPRESS - Science and Technology Publications, 2020. http://dx.doi.org/10.5220/0008953600002513.

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Animashaun, Aisha, and Gilberto Bernardes. "Noise promotes disengagement in dementia patients during non-invasive neurorehabilitation treatment." In 4th Symposium on Occupational Safety and Health. FEUP, 2021. http://dx.doi.org/10.24840/978-972-752-279-8_0009-0014.

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Introduction:The lack of engagement and the shortage of motivation and drive, also referred to as apathy, negatively impacts the effectiveness and adherence to treatment and the general well-being of people with neurocognitive disorders (NCDs), such as dementia. Methodology:The hypothesis raised states that the engagement of people with dementia during their non-invasive treatments for NCDs is affected by the noisy source levels and negative auditory stimuli present within environmental treatment settings. An online survey was conducted with the study objectives to assess 1) the engagement levels of dementia patients while interacting with others at home versus in therapy facilities, 2) the emotions perceived when interacting with people at home compared to therapy sessions, 3) the perceived loudness of the environment at home versus in therapy facilities, and 4) which source sounds negatively impact the patients at home and during therapy sessions. A purposive sampling (n=62) targeting relatives, friends, and caregivers of dementia patients was conducted via online community forums in the DACH region. Moreover, a recording session was conducted in a psychotherapist’s office to verify the answer tothe questionnaire on the noise sources perceived in therapy facilities. Results and Discussion:The raised hypothesis that disruptive auditory stimuli and noise levels influence the engagement levels of demented individuals during treatment is confirmed as the engagement is affected by the perceived noise disruptions when comparing perceived noise levels and engagement at home to those in treatment facilities.Significant statistical results were found between the lower engagement of demented individuals when interacting with people during therapy sessions compared to higher engagement in-home interactions. Furthermore, negatively perceived sound sources can be found in both therapy facilities and home settings. The noise sound sources identified, such as human voices, household appliances and household noises, while recording inthe psychotherapist’s office align with the questionnaire responses received on this topic. The findings indicate that the perceived heightened noise levels in therapy facilities stand in correlation with the lowered engagement rate perceived during the therapy session compared to the lower noise level and higher engagement encountered when demented individuals interact at home. Conclusion:If the identified noise elements are masked or replaced by other auditory stimuli that promote a soothing soundscape, the original disturbances encountered during therapy and the lack of engagement can possibly be minimized. Further studies need to be conducted in the prototyping of a noise intervention tool to analyze the impact on lack of engagement through noise disturbances.Keywords. Noise, Engagement, Dementia, Therapy, Apathy.INTRODUCTIONNeurocognitive disorders (NCDs) are a steadily rising global public health concern. In 2020, around 50 million people worldwide lived with major NCDs, specifically dementia, with nearly 10 million new cases per year1NCDs can be found in many diseases, including Alzheimer, Parkinson, Huntington, and Creutzfeldt-Jakob (Reith, 2018). The causes of NCDs are typically associated with advanced age. Still, it can occur from incidents such as traumatic brain injuries, infections, thyroid problems, damage to the blood vessels, and other causes (Kane et al., 2017), increasingly affecting a wide range of people and age groups. Successful treatment methods are limited and can be split into two main categories, invasive and non-invasive methods.Invasive treatment methods are surgical procedures, such as Deep Brain Stimulation (DBS), a neurosurgical procedure in which a neurotransmitter is placed in the brain to send electrical 1World Health Organization, Dementia [website] https://www.who.int/news-room/fact-sheets/detail/dementia(accessed 12 April 2021)

Reports on the topic "Non-invasive treatment":

1

Hsu, Chih-Wei, Ping-Tao Tseng, and Yang-Chieh Chen. Comparing different non-invasive brain stimulation interventions for bipolar depression treatment: A network meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, April 2023. http://dx.doi.org/10.37766/inplasy2023.4.0019.

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Li, Haitao, Gongwei Long, and Jun Tian. Efficacy and Safety of Photodynamic Therapy for Non–muscle-invasive Bladder Cancer: A Systematic Review and Meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, November 2022. http://dx.doi.org/10.37766/inplasy2022.11.0043.

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Review question / Objective: To comprehensively summarize the relevant clinical studies, and assess the efficacy and safety of PDT in the treatment of NMIBC. Eligibility criteria: (1) pathologically confirmed NMIBC; (2) included > 5 patients who received PDT; (3) clinical studies including randomized-controlled trials, case-control studies, and single-arm reports; (4) included efficacy and/or safety results；(5) follow-up duration > 6 months; (6) report was written in English or has a English abstract.
3

Li, Yanhui. Efficacy of non-invasive photodynamic therapy for female lower reproductive tract diseases associated with HPV infection: a comprehensive meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, November 2022. http://dx.doi.org/10.37766/inplasy2022.11.0092.

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Review question / Objective: The critical point of this study was to comprehensively evaluate the curative effect of Photodynamic therapy (PDT) in diseases of female lower reproductive tract associated with the human papillomavirus (HPV) infection. Condition being studied: Traditional clinical recommendations for treating diseases of the female lower reproductive tract include topical therapy with drugs, surgery, intravaginal radiation, carbon dioxide (CO2) laser, etc. Although medication is easy to administer, it has a high recurrence rate and adverse effects such as burning sensation, pain, and dyspareunia. The other traditional treatment method is usually invasive, repeated operation of vaginal perforation, scar, easy recurrence, fertility decline, and other shortcomings. At present, the treatment strategy for cervical squamous intraepithelial lesion, vaginal squamous intraepithelial lesion, condyloma acuminatum, and vulvar lichen sclerosis are to protect the normal organ structure and function as much as possible, reduce recurrence, prevent disease progression and carcinogenesis, and preserve female reproductive function.
4

Bernal, Pedro, Nicolás Ajzenman, Emma Iriarte, Florencia Lopez Boo, María Deni Sánchez, and María Fernanda García. Seeing Is Believing: Screening Anemia to Make Risks Salient Experimental Evidence from El Salvador. Inter-American Development Bank, May 2024. http://dx.doi.org/10.18235/0012954.

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We investigate the impact of non-invasive anemia screening on treatment adherence in El Salvador. Anemia is a common childhood condition in low-income countries, due mainly to iron-deficiency, which if left untreated during critical development periods can have lasting health consequences. While effective treatments exist, adherence to treatment is often challenging, since the symptoms of mild to moderate anemia such as lack of energy or paleness can be easily overlooked. We test whether making anemia risks salient through screening during child-well visits can improve treatment adherence, using a cluster-randomized trial in high-poverty areas in El Salvador. Preliminary results indicate that screening enhances treatment adherence and there is suggestive evidence of a reduction of anemia among children 6 to 23 months old. Our results highlight the potential of screening in making anemia risks salient and motivating caregivers to follow treatment plans.
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Schad, Aaron, Gary Dick, Kris Erickson, Paul Fuhrmann, and Lynde Dodd. Vegetation community changes in response to phragmites management at Times Beach, Buffalo, New York. Engineer Research and Development Center (U.S.), September 2021. http://dx.doi.org/10.21079/11681/42149.

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Management of invasive phragmites (Phragmites australis [Cav.] Trin. Ex Steud.) in the United States has proven challenging over the last several decades. Various methods for control exist, but integrated approaches appear to have the most success. However, documentation of vegetation community–wide responses to these approaches remains limited. This study monitored plant community changes at Times Beach, New York, over a five-year period. In concert with mowing and thatch removal in all areas, the study evaluated two herbicides separately and together, representing three experimental treatment areas (TAs), for control efficacy by measuring plant community structure. Phragmites was targeted for treatments, avoiding native and nonproblematic non-native species when possible, to preserve beneficial habitat during phragmites control efforts. Monitoring results showed significant drops in phragmites relative cover, relative frequency, and importance values due to integrated management, regardless of herbicide treatment, with corresponding increases in these same values for native and other plant species. This suggests that prudent removal of phragmites is compatible with beneficial plant restorative efforts to maintain and improve habitat in infested areas.
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Pfisterer, Nathan, and Nathan Beane. Estimating present value cost of invasive Emerald Ash Borer (Agrilus planipennis) on USACE project lands. Engineer Research and Development Center (U.S.), February 2023. http://dx.doi.org/10.21079/11681/46475.

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The US Army Corps of Engineers (USACE) is responsible for stewardship of approximately 12.5 million acres across the United States. USACE’s Environmental Stewardship program mission is to protect, preserve, and restore significant ecological resources on USACE project lands. Since the early 2000s, non-native and invasive Emerald Ash Borer (EAB) has killed hundreds of millions of ash trees in the US, becoming the most destructive and costly invasive forest insect in North America. This research effort estimates the cost of managing EAB damage to USACE projects including treatment, removal, or removal and replacement of dying/dead ash trees. The results suggest potential impact to more than 122,800 USACE project acres in currently infested counties including 181,000 ash trees. While not all damaged trees require removal, many USACE recreation sites have ash trees that pose an increased risk to humans and structures thus requiring removal of EAB infected trees. The widespread and pervasive impacts of EAB will have significant costs associated with removal and replacement of ash trees that could be hazardous to recreational users at the projects. Data from the United States Department of Agriculture (USDA), Forest Inventory and Analysis (FIA) database, and methods developed by Kovacs et al. (2010) were utilized to calculate yearly present value costs of EAB to USACE projects from 2006-2026. Overall EAB impacts are estimated at $121.6 million across 201 USACE projects evaluated in this study. Increased efforts to limit EAB spread and perform measures of control are warranted to reduce potential cost to USACE.
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Goyal, Shikha, Freny R. Karjodkar, Kaustubh Sansare, and Ankita Verma. Efficacy of Autologous Blood Injections in Treatment of Chronic Recurrent TMJ Dislocation Based on its Severity: A Prospective Study. International Journal of Surgery, March 2024. http://dx.doi.org/10.60122/j.ijs.2024.10.04.

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Aim: To study the efficacy of autologous blood injections in treatment of chronic recurrent TMJ dislocation based on the severity of the condition. Method and Material: Total 26 patients with complain of chronic recurrent bilateral TMJ dislocation were included in the study. The patients were grouped into three groups based on the frequency of episodes of TMJ dislocation: Group 1 (7 patients) included patients with minimum one episode of TMJ dislocation each day, Group 2 (5 patients) included patients with minimum of 2 episodes of TMJ dislocation each week and Group 3 (14 patients) included patients with minimum of 2 episodes in last 6 months. In each joint, 2ml of autologous blood was injected in superior joint space and 0.5 ml was injected into the peri capsular area. Post injection patients were followed for the period ranging from 6 months to the 2 years. Patients were assessed for frequency of episodes of TMJ dislocation and inter-incisal opening (IO) before the start of the treatment and during the follow up visit. Results: On long term follow up (1 to 2 years) 2 patients in Group 1 showed recurrence of TMJ dislocation. However, none of the patients from Group 2 and 3 showed recurrence of the condition. It was analyzed that success of the ABI was found to be inversely proportional to the frequency of the episodes during the pre -injection phase. Conclusion: ABI is the safe, conservative, cost effective, non- invasive and simpler treatment approach for the TMJ dislocation, however the treatment outcome is better with the patients experiencing less frequent episodes.
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Perkins, Dustin. Invasive exotic plant monitoring at Dinosaur National Monument: Results of the 2019 field season on the Green River, and the third completed monitoring rotation. Edited by Alice Wondrak Biel. National Park Service, December 2021. http://dx.doi.org/10.36967/nrr-2284627.

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Invasive exotic plant (IEP) species are a significant threat to natural ecosystem integrity and biodiversity, and controlling them is a high priority for the National Park Service. The Northern Colorado Plateau Network (NCPN) selected the early detection of IEPs as one of 11 monitoring protocols to be implemented as part of its long-term monitoring program. We also calculated a patch management index (PMI) to quantify the extent and density of invasive patches into a single value that helps identify the scale of the problem. Park managers can use this tool to help prioritize IEP treatment. At Dinosaur National Monument, the NCPN monitors IEPs in the Green and Yampa river corridors. This report summarizes data from monitoring on the Green River in 2019, and monitoring on the Yampa River in 2017, to represent the completion of the third monitoring rotation of the entire river corridor (2002–2005, 2010–2011, 2017–2019). During surveys conducted from June 26 to July 2, 2019, NCPN staff detected 12 priority IEP species and two non-priority species in a 84.6-hectare (209-acre) area along 74.4 kilometers of the Green River above (“upper”) and below (“low-er”) its confluence with the Yampa. A total of 2,535 IEP patches were detected. Of those patches, 24.2% and 15.6% were smaller than 40 m2 on the upper and lower Green River reaches, respectively. The patch management index (PMI) was low or very low for 95.7% of patches on the upper Green River and 90.9% of patches on the lower Green River. Tamarisk (Tamarix sp.), broad-leaf pepperwort (Lepidium latifolium), and yellow sweetclover (Meli-lotus officinalis) were the most widespread species. For the first time, NCPN monitoring detected teasel (Dipsacus sylvestris) on the upper Green River. Yellow sweetclover has increased on all three river reaches during the survey years. Musk thistle (Carduus nutans) was found at considerably lower levels than yellow sweetclover but has also increased on all three river reaches. Leafy spurge is increasing on the lower Green River and Yampa River. Cheatgrass was not monitored in the first rotation, but increased substantially in cover and percent frequency on all three river sections from 2010–2011 to 2017–2019. This increase may be due to a lack of recent high-flow scouring events. The highly regulated upper Green River generally has the highest number of IEPs, while the lower Green River has a moderate amount of IEPs. The largely unregulated flows of the Yampa River continue to result in a lower number of patches per kilometer, lower percent cover, and lower percent frequency than the upper or lower Green River. Network staff will return to the monument in 2022 to begin the fourth monitoring rotation.
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Rahimipour, Shai, and David Donovan. Renewable, long-term, antimicrobial surface treatments through dopamine-mediated binding of peptidoglycan hydrolases. United States Department of Agriculture, January 2012. http://dx.doi.org/10.32747/2012.7597930.bard.

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There is a need for renewable antimicrobial surface treatments that are semi- permanent, can eradicate both biofilms and planktonic pathogens over long periods of time and that do not select for resistant strains. This proposal describes a dopamine binding technology that is inexpensive, bio-friendly, non-toxic, and uses straight-forward commercially available products. The antimicrobial agents are peptidoglycanhydrolase enzymes that are non-toxic and highly refractory to resistance development. The goal of this project is to create a treatment that will be applicable to a wide variety of surfaces and will convey long-lasting antimicrobial activity. Although the immediate goal is to create staphylolytic surfaces, the technology should be applicable to any pathogen and will thus contribute to no less than 3 BARD priorities: 1) increased animal production by protecting animals from invasive and emerging diseases, 2) Antimicrobial food packaging will improve food safety and security and 3) sustainable bio- energy systems will be supported by coating fermentation vats with antimicrobials that could protect ethanolic fermentations from Lactobacillus contamination that reduces ethanol yields. The dopamine-based modification of surfaces is inspired by the strong adhesion of mussel adhesion proteins to virtually all types of surfaces, including metals, polymers, and inorganic materials. Peptidoglycanhydrolases (PGHs) meet the criteria of a surface bound antimicrobial with their site of action being extracellular peptidoglycan (the structural basis of the bacterial cell wall) that when breached causes osmotic lysis. As a proof of principle, we will develop technology using peptidoglycanhydrolase enzymes that target Staphylococcus aureus, a notoriously contagious and antimicrobial-resistant pathogen. We will test for susceptibility of the coating to a variety of environmental stresses including UV light, abrasive cleaning and dessication. In order to avoid resistance development, we intend to use three unique, synergistic, simultaneous staphylococcal enzyme activities. The hydrolases are modular such that we have created fusion proteins with three lytic activities that are highly refractory to resistance development. It is essential to use multiple simultaneous activities to avoid selecting for antimicrobial resistant strains. This strategy is applicable to both Gram positive and negative pathogens. We anticipate that upon completion of this award the technology will be available for commercialization within the time required to achieve a suitable high volume production scheme for the required enzymes (~1-2 years). We expect the modified surface will remain antimicrobial for several days, and when necessary, the protocol for renewal of the surface will be easily applied in a diverse array of environments, from food processing plants to barnyards.
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F, Verdugo-Paiva, Izcovich A, Ragusa M, and Rada G. Lopinavir/ritonavir for COVID-19: A living systematic review. Epistemonikos Interactive Evidence Synthesis, January 2024. http://dx.doi.org/10.30846/ies.4f3c02f030.v1.

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Objective Provide a timely, rigorous, and continuously updated summary of the evidence on the role of lopinavir/ritonavir in the treatment of patients with COVID-19. Methods We conducted searches in the special L.OVE (Living OVerview of Evidence) platform for COVID-19, a system that performs regular searches in PubMed, Embase, CENTRAL, and other 33 sources. We searched for randomized trials and non-randomized studies evaluating the effect of lopinavir/ritonavir versus placebo or no treatment in patients with COVID-19. Two reviewers independently evaluated potentially eligible studies, according to predefined selection criteria, and extracted data using a predesigned standardized form. We performed meta-analyses using randomeffect models and assessed overall certainty in evidence using the GRADE approach. A living, web-based version of this review will be openly available during the COVID-19 pandemic. Results Our search strategy yielded 862 references. Finally, we identified 12 studies, including two randomized trials, evaluating lopinavir/ritonavir, in addition to standard care versus standard care alone in 250 adult inpatients with COVID-19. The evidence from randomized trials shows lopinavir/ritonavir may reduce mortality (relative risk: 0.77; 95% confidence interval: 0.45 to 1.3; low certainty evidence), but the anticipated magnitude of the absolute reduction in mortality, varies across different risk groups. Lopinavir/ritonavir also had a slight reduction in the risk of requiring invasive mechanical ventilation, developing respiratory failure, or acute respiratory distress syndrome. However, it did not lead to any difference in the duration of hospitalization and may lead to an increase in the number of total adverse effects. The overall certainty of the evidence was low or very low. Conclusions For severe and critical patients with COVID-19, lopinavir/ritonavir might play a role in improving outcomes, but the available evidence is still limited. A substantial number of ongoing studies should provide valuable evidence to inform researchers and decision-makers soon Keywords COVID-19, Severe acute respiratory syndrome coronavirus 2, Coronavirus Infections, Systematic review, Lopinavir, Lopinavir/ritonavir, Antivirals

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