Log in

Relevant bibliographies by topics / Non-insulin-dependent diabetes – Complications / Journal articles

To see the other types of publications on this topic, follow the link: Non-insulin-dependent diabetes – Complications.

Journal articles on the topic 'Non-insulin-dependent diabetes – Complications'

Author: Grafiati

Published: 4 June 2021

Last updated: 10 February 2022

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 journal articles for your research on the topic 'Non-insulin-dependent diabetes – Complications.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

Watkins, P. J., A. Grenfell, and M. Edmonds. "Diabetic Complications of Non-insulin-dependent Diabetes." Diabetic Medicine 4, no. 4 (July 8, 1987): 293–96. http://dx.doi.org/10.1111/j.1464-5491.1987.tb00882.x.

Full text

APA, Harvard, Vancouver, ISO, and other styles

2

Humphrey, Linda L., and David J. Ballard. "Renal Complications in Non-insulin-dependent Diabetes Mellitus." Clinics in Geriatric Medicine 6, no. 4 (November 1990): 807–25. http://dx.doi.org/10.1016/s0749-0690(18)30582-2.

Full text

APA, Harvard, Vancouver, ISO, and other styles

3

Julien, Jacques. "Cardiac complications in non-insulin-dependent diabetes mellitus." Journal of Diabetes and its Complications 11, no. 2 (March 1997): 123–30. http://dx.doi.org/10.1016/s1056-8727(96)00091-8.

Full text

APA, Harvard, Vancouver, ISO, and other styles

4

McLellan, Antony C., Paul J. Thornalley, Jonathan Benn, and Peter H. Sonksen. "Glyoxalase System in Clinical Diabetes Mellitus and Correlation with Diabetic Complications." Clinical Science 87, no. 1 (July 1, 1994): 21–29. http://dx.doi.org/10.1042/cs0870021.

Full text

Abstract:

1. The metabolism of methylglyoxal by the glyoxalase system may be linked to the development of diabetic complications. The glyoxalase system was characterized in blood samples from patients with insulin-dependent diabetes mellitus (n = 43), patients with non-insulin-dependent diabetes mellitus (n = 107) and 21 normal healthy control subjects. 2. The concentrations of glyoxalase metabolites, methylglyoxal, S-D-lactoylglutathione and D-lactate, were increased in diabetic patients, relative to normal control subjects: methylglyoxal [median, range (n) pmol/g], insulin-dependent patients, 470.7, 85.6-1044.3 (42), P < 0.001, non-insulin-dependent patients, 286.8, 54.7-2370 (105), P < 0.001, control subjects, 79.8, 25.3-892.9 (21); S-D-lactoylglutathione [mean ± SD (n) pmol/106 erythrocytes], combined diabetic patients, 3.37 ± 0.85 (24), control subjects 4.76 ± 1.95 (8) P < 0.05; D-lactate [mean ± SD or median, range (n) nmol/g], insulin dependent patients, median 18.3, 5.7-57.4 (42), P < 0.001, non-insulin-dependent patients, 20.0 ± 8.9, 2.6-48.4 (105), P < 0.001, control subjects 9.7 ± 4.3, 1.8-19.7 (21). The reduced glutathione concentrations in blood samples from the insulin-dependent and non-insulin-dependent diabetic patient groups were not different from the control group values (P>0.05). 3. The activities of glyoxalase enzymes in erythrocytes were increased: glyoxalase I activity [mean ± SD (n) m-units/106 erythrocytes] was increased in diabetic patients, relative to normal control subjects: insulin-dependent patients, 4.35 ± 1.54 (41), P < 0.001; non-insulin-dependent patients, 4.61 ± 1.79 (101), P < 0.001; control subjects, 3.21 ± 1.81 (21); glyoxalase II activity [mean ± SD (n) m-units/106 erythrocytes] was increased in the non-insulin-dependent diabetic patient group, relative to normal control subjects [non-insulin-dependent diabetic patients, 2.10 ± 0.46 (102); subject controls, 1.83 ± 0.27 (21); P < 0.05]. 4. In insulin-dependent diabetic patients, the concentration of methylglyoxal correlated positively with the duration of diabetes, and the concentration of D-lactate correlated positively with haemoglobin A1c and negatively with the reduced glutathione concentration. D-Lactate concentration correlated positively with blood glucose concentration in patients with non-insulin-dependent diabetes mellitus. 5. There was a positive logistic correlation of duration of disease with retinopathy, nephropathy, neuropathy, or any combination thereof. Retinopathy also gave a positive logistic correlation with haemoglobin A1c concentrations and a negative logistic correlation with D-lactate concentration. 6. When paired for duration of diabetes, patients with retinopathy, neuropathy or nephropathy, or any combination thereof, had significantly higher age, level of haemoglobin A1c and glyoxalase I activity than patients with uncomplicated diabetes (P < 0.05). 7. We conclude that the glyoxalase system is modified in erythrocytes in both insulin-dependent and non-insulin-dependent diabetic patients and that this modification is related to the development of diabetic complications.

APA, Harvard, Vancouver, ISO, and other styles

5

Morimoto, Yasuo, Hiroshi Taniguchi, Yuki Yamashiro, Kazushige Ejiri, Shigeaki Baba, and Yasufumi Arimoto. "Complements in non-insulin-dependent diabetes mellitus with complications." Diabetes Research and Clinical Practice 5, no. 3 (September 1988): 233–38. http://dx.doi.org/10.1016/s0168-8227(88)80093-7.

Full text

APA, Harvard, Vancouver, ISO, and other styles

6

Ilarde, Aldo, and Michael Tuck. "Treatment of Non-Insulin-Dependent Diabetes Mellitus and its Complications." Drugs & Aging 4, no. 6 (June 1994): 470–91. http://dx.doi.org/10.2165/00002512-199404060-00004.

Full text

APA, Harvard, Vancouver, ISO, and other styles

7

Wolffenbuttel, Bruce H. R., and Timon W. van Haeften. "Prevention of Complications in Non-Insulin-Dependent Diabetes Mellitus (NIDDM)." Drugs 50, no. 2 (August 1995): 263–88. http://dx.doi.org/10.2165/00003495-199550020-00006.

Full text

APA, Harvard, Vancouver, ISO, and other styles

8

Haddix, Kevin P., R. Carter Clement, Joshua N. Tennant, and Robert F. Ostrum. "Complications Following Operatively Treated Ankle Fractures in Insulin- and Non–Insulin-Dependent Diabetic Patients." Foot & Ankle Specialist 11, no. 3 (June 15, 2017): 206–16. http://dx.doi.org/10.1177/1938640017714867.

Full text

Abstract:

Background: Diabetics with ankle fractures experience more complications than the general population, but it is unclear whether complications differ between type 1 and 2 diabetics and between insulin- and non–insulin-dependent diabetics. This study aims to determine if there is a difference in postoperative complication rates between these groups. Methods: An administrative health care database from a large commercial insurer was queried to identify operatively treated ankle fractures in patients with type 1 (T1D), type 2 (T2D), type 2 insulin-dependent (T2ID), and type 2 non–insulin-dependent (T2NID) diabetes. Postoperative complications were identified to include postoperative stiffness, posttraumatic arthritis, amputation, implant removal, and infection. Subgroup analysis was performed to control for comorbidities. Results: A total of 20 703 closed and 2873 open operatively treated ankle fractures were identified. Patients with T1D experienced higher rates of amputation, postoperative infection, and total complications than patients with T2D (P < .05). Patients with T2ID experienced higher rates of amputation, infection, and total complications than those with T2NID (P < .0001). Subgroup analysis controlling for comorbidities showed a higher total complication rate for T1D compared with T2D in closed ankle fractures (P < .02) and for T2ID compared with T2NID in both open and closed ankle fractures (P < .0001). Conclusions: Patients with T1D and T2ID have higher complication rates than patients with T2D and T2NID, respectively. Foot and ankle surgeons should be cautioned not to classify diabetics as one cohort and should use these findings to stratify risk among this patient population. Levels of Evidence: Level III: Diagnostic

APA, Harvard, Vancouver, ISO, and other styles

9

Nosadini, R., and E. Brocco. "Relationships among microalbuminuria, insulin resistance and renal-cardiac complications in insulin dependent and non insulin dependent diabetes." Experimental and Clinical Endocrinology & Diabetes 105, S 02 (July 14, 2009): 1–7. http://dx.doi.org/10.1055/s-0029-1211783.

Full text

APA, Harvard, Vancouver, ISO, and other styles

10

Warram, James H., Jan Kopczynski, Hans U. Janka, and Andrzej S. Krolewski. "EPIDEMIOLOGY OF NON-INSULIN-DEPENDENT DIABETES MELLITUS AND ITS MACROVASCULAR COMPLICATIONS." Endocrinology and Metabolism Clinics of North America 26, no. 1 (March 1997): 165–88. http://dx.doi.org/10.1016/s0889-8529(05)70239-5.

Full text

APA, Harvard, Vancouver, ISO, and other styles

11

Morano, Susanna, Claudio Tiberti, Giuseppe Cristina, Maurizio Sensi, Rosalba Cipriani, Leo Guidobaldi, Patrizia Torresi, Francesco Medici, Emanuela Anastasi, and Umberto Di Mario. "Autoimmune markers and neurological complications in non-insulin-dependent diabetes mellitus." Human Immunology 60, no. 9 (September 1999): 848–54. http://dx.doi.org/10.1016/s0198-8859(99)00051-8.

Full text

APA, Harvard, Vancouver, ISO, and other styles

12

Clark, Tod A., and Grant N. Pierce. "Cardiovascular complications of non-insulin-dependent diabetes The JCR:LA-cp rat." Journal of Pharmacological and Toxicological Methods 43, no. 1 (February 2000): 1–10. http://dx.doi.org/10.1016/s1056-8719(00)00081-2.

Full text

APA, Harvard, Vancouver, ISO, and other styles

13

Mehler, P. "Associations of hypertension and complications in non-insulin-dependent diabetes mellitus." American Journal of Hypertension 10, no. 2 (February 1997): 152–61. http://dx.doi.org/10.1016/s0895-7061(96)00344-5.

Full text

APA, Harvard, Vancouver, ISO, and other styles

14

WEIJERS, R. N. M., H. M. J. GOLDSCHMIDT, and J. SILBERBUSCH. "Vascular complications in relation to ethnicity in non-insulin-dependent diabetes mellitus." European Journal of Clinical Investigation 27, no. 3 (November 14, 2003): 182–88. http://dx.doi.org/10.1046/j.1365-2362.1997.840637.x.

Full text

APA, Harvard, Vancouver, ISO, and other styles

15

Fontbonne, A. "Cardiovascular complications of non-insulin-dependent diabetes. The difficult search for causality." Circulation 88, no. 4 (October 1993): 1952–53. http://dx.doi.org/10.1161/01.cir.88.4.1952.

Full text

APA, Harvard, Vancouver, ISO, and other styles

16

Wiggans, M. G., J. T. Lordan, G. Shahtahmassebi, S. Aroori, M. J. Bowles, and D. A. Stell. "The Interaction between Diabetes, Body Mass Index, Hepatic Steatosis, and Risk of Liver Resection: Insulin Dependent Diabetes Is the Greatest Risk for Major Complications." HPB Surgery 2014 (August 14, 2014): 1–10. http://dx.doi.org/10.1155/2014/586159.

Full text

Abstract:

Background. This study aimed to assess the relationship between diabetes, obesity, and hepatic steatosis in patients undergoing liver resection and to determine if these factors are independent predictors of major complications. Materials and Methods. Analysis of a prospectively maintained database of patients undergoing liver resection between 2005 and 2012 was undertaken. Background liver was assessed for steatosis and classified as <33% and ≥33%. Major complications were defined as Grade III–V complications using the Dindo-Clavien classification. Results. 504 patients underwent liver resection, of whom 56 had diabetes and 61 had steatosis ≥33%. Median BMI was 26 kg/m2 (16–54 kg/m2). 94 patients developed a major complication (18.7%). BMI ≥ 25 kg/m2 (P=0.001) and diabetes (P=0.018) were associated with steatosis ≥33%. Only insulin dependent diabetes was a risk factor for major complications (P=0.028). Age, male gender, hypoalbuminaemia, synchronous bowel procedures, extent of resection, and blood transfusion were also independent risk factors. Conclusions. Liver surgery in the presence of steatosis, elevated BMI, and non-insulin dependent diabetes is not associated with major complications. Although diabetes requiring insulin therapy was a significant risk factor, the major risk factors relate to technical aspects of surgery, particularly synchronous bowel procedures.

APA, Harvard, Vancouver, ISO, and other styles

17

Kikkawa, R., S. Araki, M. Haneda, N. Kajiwara, H. Hidaka, and Y. Shigeta. "Hypertension and the development of complications in patients with non-insulin dependent diabetes mellitus in Japan." Journal of the American Society of Nephrology 3, no. 4 (October 1992): S120. http://dx.doi.org/10.1681/asn.v34s120.

Full text

Abstract:

Hypertension is a very frequent condition in individuals with non-insulin dependent diabetes mellitus (NIDDM) in Japan and has affected the occurrence of late diabetic complications, especially stroke and nephropathy. Despite similar characteristics of hypertension among Japanese and white patients, the effect of hypertension on the development of coronary artery disease (CAD) in these two populations is strikingly different. In white NIDDM patients, hypertension is one of the major risk factors for the development of CAD. However, CAD is an infrequent complication in NIDDM patients in Japan, even though they have hypertension, lipid abnormalities, and renal complications.

APA, Harvard, Vancouver, ISO, and other styles

18

Chan, J. C. N., B. R. Hawkins, and C. S. Cockram. "A Chinese Family with Non-insulin-dependent Diabetes of Early Onset and Severe Diabetic Complications." Diabetic Medicine 7, no. 3 (March 4, 1990): 211–14. http://dx.doi.org/10.1111/j.1464-5491.1990.tb01372.x.

Full text

APA, Harvard, Vancouver, ISO, and other styles

19

Wirta, Ole R., Amos I. Pasternack, Heikki H. Oksa, Jukka T. Mustonen, Timo A. Koivula, Heikki J. Helin, and YrjöE K. Lähde. "Occurrence of late specific complications in type II (non-insulin-dependent) diabetes mellitus." Journal of Diabetes and its Complications 9, no. 3 (July 1995): 177–85. http://dx.doi.org/10.1016/1056-8727(94)00034-l.

Full text

APA, Harvard, Vancouver, ISO, and other styles

20

Kudryakova, S. V., Yu I. Suntsov, and S. G. Ryzhkova. "Incidence of diabetes mellitus complications as indicated by the register." Problems of Endocrinology 41, no. 4 (August 15, 1995): 8–11. http://dx.doi.org/10.14341/probl11451.

Full text

Abstract:

The incidence of diabetes mellitus complications was assessed on the basis of diabetes mellitus register in 1478 diabetics living in the Lenin district of Moscow. The incidence of microangiopathies was reliably higher in patients with insulin-dependent condition (IDDM) than in those with the non-insulin dependent (NIDDM) one. The incidence of retinopathies and nephropathies was much higher in women with IDDM than in men. The incidence of macroangioptithies was higher in NIDDM than in those with IDDM. The incidence of coronary disease and arterial hypertension was the highest in women with NIDDM. The incidence of complications increased with a longer standing of the disease and age of the patients.

APA, Harvard, Vancouver, ISO, and other styles

21

VINIK, AARON I., and DONALD W. RICHARDSON. "Implications of the Diabetes Control and Complications Trial for Persons With Non-Insulin-Dependent Diabetes Mellitus." Southern Medical Journal 90, no. 3 (March 1997): 268–83. http://dx.doi.org/10.1097/00007611-199703000-00001.

Full text

APA, Harvard, Vancouver, ISO, and other styles

22

&NA;. "Intensive Insulin Therapy Prevents the Progression of Diabetic Microvascular Complications in Japanese Patients with Non-Insulin Dependent Diabetes Mellitus." Endocrinologist 6, no. 2 (March 1996): 160. http://dx.doi.org/10.1097/00019616-199603000-00028.

Full text

APA, Harvard, Vancouver, ISO, and other styles

23

Thornalley, P. J., A. C. McLellan, T. W. C. Lo, J. Benn, and P. H. Sönksen. "Negative Association between Erythrocyte Reduced Glutathione Concentration and Diabetic Complications." Clinical Science 91, no. 5 (November 1, 1996): 575–82. http://dx.doi.org/10.1042/cs0910575.

Full text

Abstract:

1. Multiple logistic regression analysis of biochemical and clinical variables in diabetic patients was performed to identify those associated with the presence of diabetic complications (retinopathy, neuropathy and nephropathy). 2. The presence of diabetic complications correlated positively with duration of diabetes and patient age and negatively with the concentration of reduced glutathione in erythrocytes. Individually, retinopathy, neuropathy and nephropathy correlated with duration of diabetes, but retinopathy also correlated positively with haemoglobin A1c in diabetic patients. In insulin-dependent patients, the concentration of methylglyoxal was also in the logistic model for retinopathy and diabetic complications, but the logistic regression coefficient was not significant. 3. Multiple linear regression analysis indicated that erythrocyte reduced glutathione concentration correlated negatively with d-lactate concentration and positively with duration of diabetes in insulin-dependent patients and correlated negatively with glucose concentration in non-insulin-dependent diabetic patients. 4. In non-diabetic subjects, erythrocyte glyoxalase I activity correlated positively with methylglyoxal concentration. There was no similar correlation in diabetic patients. In insulin-dependent patients, methylglyoxal concentration correlated positively with duration of diabetes. 5. Glyoxal and methylglyoxal are detoxified by the glyoxalase system with reduced glutathione as co-factor. The concentration of reduced glutathione may be decreased by oxidative stress and by decreased in situ glutathione reductase activity in diabetes mellitus. A reduced concentration of reduced glutathione may predispose diabetic patients to oxidative damage and to α-oxoaldehyde-mediated glycation by decreasing the in situ glyoxalase I activity. Recent studies of vascular endothelial cells in vitro have suggested that α-oxoaldehydes detoxified by glyoxalase I are the major precursors of advanced glycation end products implicated in the development of diabetic complications. The role of these factors in the development of diabetic complications and the prospective prevention of diabetic complications by supplementation of reduced glutathione and/or α-oxoaldehyde-scavenging agents now deserve investigation.

APA, Harvard, Vancouver, ISO, and other styles

24

NAKAMURA, TOMOATSU, KAZUFUMI HONDA, SAN-E. ISHIKAWA, KAZUO KITAMURA, TANENAO ETO, and TOSHIKAZU SAITO. "Plasma Adrenomedullin Levels in Patients with Non-Insulin Dependent Diabetes Mellitus: Close Relationships with Diabetic Complications." Endocrine Journal 45, no. 2 (1998): 241–46. http://dx.doi.org/10.1507/endocrj.45.241.

Full text

APA, Harvard, Vancouver, ISO, and other styles

25

Chico, Ana, Antonio Pérez, Assumpta Caixàs, Jordi Ordoñez, Josep M. Pou, and Alberto de Leiva. "Lipoprotein(a) concentrations and non-insulin-dependent diabetes mellitus: relationship to glycaemic control and diabetic complications." Diabetes Research and Clinical Practice 33, no. 2 (July 1996): 105–10. http://dx.doi.org/10.1016/0168-8227(96)01285-5.

Full text

APA, Harvard, Vancouver, ISO, and other styles

26

Hota, Parthasarathi. "Testicular necrosis: a rare complication of poorly controlled diabetes mellitus." International Surgery Journal 8, no. 4 (March 26, 2021): 1340. http://dx.doi.org/10.18203/2349-2902.isj20211321.

Full text

Abstract:

A case presented here depicting testicular necrosis in a 45 years old male patient with diabetes mellitus. Past history suggestive of diabetes with very irregular medication. Patient presented with gradually increasing right testicular enlargement for three weeks. Ultrasonography showed abscess formation with no vascularity in right testis. Right orchiectomy done. Histopathology report confirmed testicular necrosis. Testicular necrosis is a common complication after torsion which leads to orchiectomy. In those cases, patients present with acute onset pain in the scrotum, usually unilateral. On examination there is acutely tender testis with red and angry looking overlying skin. In diabetic patients, urinary tract infections are common occurrence as well as epididymo-orchitis. Patients present with testicular pain with fever, leucocytosis etc. But testicular necrosis is extremely rare. Long term complications specific to diabetes mellitus include retinopathy, nephropathy and neuropathy. Patients with all forms of diabetes of sufficient duration, including insulin-dependent diabetes mellitus and non-insulin-dependent diabetes mellitus, are vulnerable to these complications, which cause serious morbidity. Testicular necrosis is a very rare complication of diabetes mellitus. An internet search did not reveal any article of testicular necrosis as a complication of diabetes. A case of unilateral testicular necrosis as a complication of diabetes mellitus is presented here for the first time. Probably accelerated microangiopathy along with poor control of blood glucose led to this unique complication.

APA, Harvard, Vancouver, ISO, and other styles

27

HASEYAMA, TOSHIYUKI, TOSHIKI FUJITA, FUJIKO HIRASAWA, MIKAKO TSUKADA, HIDEKI WAKUI, ATSUSHI KOMATSUDA, HIROSHI OHTANI, AKIRA B. MIURA, HIROKAZU IMAI, and AKIO KOIZUMI. "Complications of IgA Nephropathy in a Non-Insulin-Dependent Diabetes Model, the Akita Mouse." Tohoku Journal of Experimental Medicine 198, no. 4 (2002): 233–44. http://dx.doi.org/10.1620/tjem.198.233.

Full text

APA, Harvard, Vancouver, ISO, and other styles

28

Delcourt, Cécile, Françoise Vauzelle-Kervroedan, Gérard Cathelineau, and Laure Papoz. "Low Prevalence of Long-Term Complications in Non–Insulin-Dependent Diabetes Mellitus in France." Journal of Diabetes and its Complications 12, no. 2 (March 1998): 88–95. http://dx.doi.org/10.1016/s1056-8727(97)98005-3.

Full text

APA, Harvard, Vancouver, ISO, and other styles

29

Virtaniemi, Jukka, Markku Laakso, Juhani Nuutinen, Seppo Karjalainen, and Eero Vartiainen. "Hearing thresholds in insulin-dependent diabetic patients." Journal of Laryngology & Otology 108, no. 10 (October 1994): 837–41. http://dx.doi.org/10.1017/s0022215100128270.

Full text

Abstract:

AbstractHearing thresholds were studied in 53 patients with insulin-dependent diabetes mellitus (IDDM) and 42 randomly selected non-diabetic control subjects, aged between 20 and 40 years. The hearing level tended to be worse in diabetic patients than in control subjects, but the differences were statistically significant only at frequencies of 6000 and 8000 Hz. Microvascular complications (retinopathy and nephropathy), and the duration of diabetes were associated with the elevated hearing thresholds. In contrast, poor metabolic control (high fasting blood glucose and glycated haemoglobin Alc) was not associated with increased hearing thresholds. The changes caused by diabetic neuropathy appeared simultaneously with microvascular complications and a long duration of the diabetes, and thus a causative role of diabetic neuropathy in the pathogenesis of elevated hearing thresholds remained unsolved. It was concluded that elevated sensorineural hearing thresholds at the frequencies of 6000 and 8000 Hz in patients with IDDM are probably caused by the long duration of diabetes and the microvascular complications associated with it.

APA, Harvard, Vancouver, ISO, and other styles

30

MAILLET, NANCY A., GAIL D'ERAMO MELKUS, and GERALYN SPOLLETT. "Using Focus Groups to Characterize the Health Beliefs and Practices of Black Women with Non-Insulin-Dependent Diabetes." Diabetes Educator 22, no. 1 (February 1996): 39–46. http://dx.doi.org/10.1177/014572179602200106.

Full text

Abstract:

The purpose of this focus group intervention was to characterize the health beliefs, self care practices, diabetes education needs, weight-loss issues, and facilitators and barriers to diabetes health care in black women with non-insulin-dependent diabetes. Major themes that emerged from the focus group were motivation to prevent complications, unrealistic weight goals set by providers, multiple barriers to diet and exercise, and a dual role of family as supporter and deterrent to diabetes management, especially related to diet. These findings suggest that culturally sensitive and appropriate patient educational programs must be provided for minority groups such as black women who have higher rates of diabetes-related complications.

APA, Harvard, Vancouver, ISO, and other styles

31

Iqbal, Anbreen, Muhammad Imran Qadir, and Muhammad Asif. "Modern technologies in management of diabetes." Journal of College of Medical Sciences-Nepal 13, no. 2 (July 17, 2017): 296–301. http://dx.doi.org/10.3126/jcmsn.v13i2.16921.

Full text

Abstract:

Diabetes is not one disease but rather is a heterogeneous group of syndromes characterized by an elevation of fasting blood glucose caused by a relative or absolute deficiency in insulin. The two main types of diabetes occur, type-1 is insulin dependent diabetes mellitus and type-2 is non insulin dependent diabetes mellitus. In type-1 body does not produce insulin and about 10% of all diabetic patients are affected. In type-2 diabetes imbalance of insulin and glucose occur and there are about 90% cases for type-2 diabetes. Gestational diabetes is also a type of diabetes and it is found mostly in women’s who are pregnant later such women’s are affected with type-2 diabetes and about 40% cases are studied. Different countries are affected at high level from diabetes. For the treatment of diabetes different techniques like insulin injection, oral vaccination, pancreas transplantation, transplantation of encapsulated islet cells, gene therapy technique and islet cell transplantation are used. All techniques have some advantages and disadvantages, but the encapsulated islet cell transplantation technique is promising with minimum complications.

APA, Harvard, Vancouver, ISO, and other styles

32

Ikeda, Yukio, Tadashi Suehiro, Mari Inoue, Yuh Nakauchi, Tatsuhito Morita, Kaoru Arii, Hiroyuki Ito, Yoshitaka Kumon, and Kozo Hashimoto. "Serum paraoxonase activity and its relationship to diabetic complications in patients with non—insulin-dependent diabetes mellitus." Metabolism 47, no. 5 (May 1998): 598–602. http://dx.doi.org/10.1016/s0026-0495(98)90246-3.

Full text

APA, Harvard, Vancouver, ISO, and other styles

33

Sundaram, Ranjini K., Anusha Bhaskar, Selvamani Vijayalingam, Moopil Viswanathan, Rema Mohan, and Kalathinkal R. Shanmugasundaram. "Antioxidant Status and Lipid Peroxidation in Type II Diabetes Mellitus with and without Complications." Clinical Science 90, no. 4 (April 1, 1996): 255–60. http://dx.doi.org/10.1042/cs0900255.

Full text

Abstract:

1. This study was conducted on 467 cases of non-insulin-dependent diabetes mellitus and 180 healthy controls. Lipid peroxidation products in plasma and erythrocytes were assayed as thiobarbituric acid reactive substances, along with the erythrocyte antioxidant enzymes, namely superoxide dismutase, catalase and glutathione peroxidase. In addition, scavenger vitamins A, C and E and reduced glutathione levels in blood were also measured. 2. Lipid peroxidation was significantly raised within the first 2 years of diagnosis, and superoxide dismutase, catalase, reduced glutathione and vitamins C and E were significantly lowered. 3. These changes were correlated with the duration of the disease and were of a higher magnitude with the development of complications. 4. The results suggest that the antioxidant deficiency and excessive peroxide-mediated damage may appear early on in non-insulin-dependent diabetes mellitus, before the development of secondary complications.

APA, Harvard, Vancouver, ISO, and other styles

34

Grzeszczak, W., M. J. Zychma, B. Lacka, and E. Zukowska-Szczechowska. "Angiotensin I-converting enzyme gene polymorphisms: relationship to nephropathy in patients with non-insulin dependent diabetes mellitus." Journal of the American Society of Nephrology 9, no. 9 (September 1998): 1664–69. http://dx.doi.org/10.1681/asn.v991664.

Full text

Abstract:

Nephropathy is a frequent complication of long-term diabetes. Strong evidence exists that genetic predisposition plays a major role in the development of diabetic nephropathy. The role of the angiotensin I-converting enzyme gene (ACE) in the susceptibility to nephropathy in diabetes, especially in non-insulin dependent diabetes mellitus (NIDDM), remains unclear. This study examines the association of two ACE polymorphisms: a 287-bp insertion/deletion (I/D) in intron 16 and PstI (A/G substitution in intron 7; alleles P/M) with renal complications in 941 NIDDM patients. From this group, for further analysis 127 patients were selected with overt proteinuria or chronic renal failure, 335 patients with microalbuminuria, and a control group of 254 normoalbuminuric patients with a diabetes duration of at least 10 yr. No significant differences in the distribution of ACE I/D and PstI genotypes or allele frequencies were observed between the examined groups. The results of this study strongly suggest that there is no association between the ACE gene I/D and PstI polymorphisms and nephropathy in NIDDM.

APA, Harvard, Vancouver, ISO, and other styles

35

Asami, M., Y. Takitani, Y. Fujisawa, T. Takamiya, T. Tunajima, M. Asami, M. Ejiri, and M. Yoshida. "The frequencies of diabetic complications in elderly non-insulin dependent diabetic patients in Himeji." Diabetes Research and Clinical Practice 34 (October 1996): S79—S83. http://dx.doi.org/10.1016/s0168-8227(96)90012-1.

Full text

APA, Harvard, Vancouver, ISO, and other styles

36

Tai, Tong-Yuan, Lee-Ming Chuang, Chin-Hsiao Tseng, Huey-Peir Wu, Muh-Shi Chen, and Boniface J. Lin. "Microalbuminuria and diabetic complications in Chinese non-insulin-dependent diabetic patients: a prospective study." Diabetes Research and Clinical Practice 9, no. 1 (January 1990): 59–63. http://dx.doi.org/10.1016/0168-8227(90)90010-q.

Full text

APA, Harvard, Vancouver, ISO, and other styles

37

Almola, Hammad Fadl, and Riyadh Hamed. "Correlation between Certain Complications and Health Education Program among Non-Insulin Dependent Diabetes Miletus Patients." International Journal of Medical and Health Sciences Research 2, no. 10 (2015): 171–76. http://dx.doi.org/10.18488/journal.9/2015.2.10/9.10.171.176.

Full text

APA, Harvard, Vancouver, ISO, and other styles

38

Peacock, I., M. Hawkins, and S. Heptinstall. "Platelet Behaviour in Non-Insulin-Dependent Diabetes -Influence of Vascular Complications, Treatment and Metabolic Control." Thrombosis and Haemostasis 55, no. 03 (1986): 361–65. http://dx.doi.org/10.1055/s-0038-1661564.

Full text

Abstract:

SummaryPlatelet-rich plasma was prepared from 47 patients with noninsulin-dependent diabetes treated with glibenclamide and metformin, and 21 controls. The release of radio-labelled 5-hydroxy-tryptamine in response to aggregating agents (adenosine diphosphate, adrenaline and sodium arachidonate), and the effects on release of a selective thromboxane inhibitor (UK-34787) were investigated. Subsequently, 20 of the diabetic subjects were chosen at random for treatment with insulin; the remainder continued to take tablets. Platelet studies were then repeated, in all patients, after 4 and 6 months.The results showed an association between platelet behaviour and the presence of vascular complications, and were consistent with previous observations of reduced platelet reactivity in patients taking sulphonylureas. There was no correlation of platelet reactivity with blood glucose, glycosylated haemoglobin or lipid levels.

APA, Harvard, Vancouver, ISO, and other styles

39

Begum, SA, R. Afroz, Q. Khanam, A. Khanom, and TS Choudhury. "Diabetes Mellitus and Gestational Diabetes Mellitus." Journal of Paediatric Surgeons of Bangladesh 5, no. 1 (June 30, 2015): 30–35. http://dx.doi.org/10.3329/jpsb.v5i1.23887.

Full text

Abstract:

Diabetes mellitus (DM), also known as simply diabetes, is a group of metabolic diseases in which there are high blood sugar levels over a prolonged period. Worldwide in 2012 and 2013 diabetes resulted in 1.5 to 5.1 million deaths per year, making it the 8th leading cause of death. Diabetes overall at least doubles the risk of death. This high blood sugar produces the symptoms of frequent urination, increased thirst, and increased hunger. Untreated, diabetes can cause many complications. Acute complications include diabetic ketoacidosis and nonketotic hyperosmolar coma. Serious long-term complications include heart disease, stroke, kidney failure, foot ulcers and damage to the eyes. The number of people with diabetes is expected to rise to 592 million by 2035. The economic costs of diabetes globally were estimated in 2013 at $548 billion and in the United States in 2012 $245 billion. [3]Globally, as of 2013, an estimated 382 million people have diabetes worldwide, with type 2 diabetes making up about 90% of the cases. This is equal to 8.3% of the adults population, with equal rates in both women and men. There are three main types of diabetes mellitus: In case of type 1 Diabetes mellitus, results from the bodys failure to produce enough insulin. This form was previously referred to as insulin-dependent diabetes mellitus (IDDM) or juvenile diabetes. The cause is unknown. Another type is type 2 diabetes mellitus begins with insulin resistance, a condition in which cells fail to respond to insulin properly. As the disease progresses a lack of insulin may also develop. This form was previously referred to as non insulin-dependent diabetes mellitus (NIDDM) or adult-onset diabetes. The primary cause is excessive body weight and not enough exercise. Gestational diabetes is the third main form and occurs when pregnant women without a previous history of diabetes develop a high blood glucose level. Gestational diabetes usually resolves after the birth of the baby. It occurs in about 210% of all pregnancies and may improve or disappear after delivery. However, after pregnancy approximately 510% of women with gestational diabetes are found to have diabetes mellitus, most commonly type 2. Gestational diabetes is fully treatable, but requires careful medical supervision throughout the pregnancy.J. Paediatr. Surg. Bangladesh 5(1): 30-35, 2014 (January)

APA, Harvard, Vancouver, ISO, and other styles

40

Kondratiev, Y. Yu, V. V. Nosikov, and I. I. Dedov. "Polymorphic genetic markers and vascular complications of diabetes." Problems of Endocrinology 44, no. 1 (February 1, 1998): 43–51. http://dx.doi.org/10.14341/probl199844143-51.

Full text

Abstract:

Diabetes mellitus is a clinically and genetically heterogeneous disease characterized by absolute or relative insulin deficiency and (or) peripheral tissue resistance to the hormone. Each of these disorders individually or in various combinations reduces tissue glucose consumption and increases the concentration of this monosaccharide in the patient’s blood. The state of hyperglycemia is a necessary and, over time, sufficient condition for the development of the so-called late complications of diabetes mellitus (mainly vascular - diabetic angiopathies). These chronic complications of diabetes are the main cause of high disability and mortality in patients, thus representing not only a serious medical and social, but also an economic problem [60]. This problem is exacerbated by the fact that recently there has been a tendency to an increase in the incidence of diabetes [42], the expected prevalence of which by 2010 will be about 215 million people [59]. In addition, the most common form of the disease, non-insulin-dependent (type II) diabetes mellitus (NIDDM), is characterized by delayed diagnosis and under-detection of the disease in the general population, leading to a significantly underestimated estimate of its prevalence [29, 30].

APA, Harvard, Vancouver, ISO, and other styles

41

Barbato, Mariana Tremel, Paulo Ricardo Criado, Ana Kris da Silva, Evelyne Averbeck, Marina Bensen Guerine, and Naiana Bittencourt de Sá. "Association of acanthosis nigricans and skin tags with insulin resistance." Anais Brasileiros de Dermatologia 87, no. 1 (February 2012): 97–104. http://dx.doi.org/10.1590/s0365-05962012000100012.

Full text

Abstract:

Insulin resistance is a metabolic disorder in which target cells fail to respond to normal levels of circulating insulin. Insulin resistance has been associated with presence of acanthosis nigricans and acrochordons. It is known that early diagnosis and early initial treatment are of paramount importance to prevent a series of future complications. These dermatoses may represent an easily identifiable sign of insulin resistance and non-insulin-dependent diabetes.

APA, Harvard, Vancouver, ISO, and other styles

42

Raymond, Nicole R., and Gail D'Eramo-Melkus. "Non-Insulin-Dependent Diabetes and Obesity in the Black and Hispanic Population: Culturally Sensitive Management." Diabetes Educator 19, no. 4 (August 1993): 313–17. http://dx.doi.org/10.1177/014572179301900411.

Full text

Abstract:

The prevalence of diabetes is considerably higher among ethnic minorities, particularly black and Hispanic Americans, than in the nonminority white population. Obesity, a significant risk factor for non-insulin-dependent diabetes mellitus (NIDDM), also is more common in these ethnic groups. Because the combined effects of obesity and NIDDM can lead to potentially serious complications, overweight patients with NIDDM must be treated aggressively. However, effective treatment of these ethnic groups requires a sensitivity to and recognition of their unique cultural values. Diabetes educators and health care providers need to take into account specific ethnic beliefs, customs, food patterns, and health care practices, with the goal of incorporating these cultural factors into a practical and beneficial treatment regimen.

APA, Harvard, Vancouver, ISO, and other styles

43

Talabani, Namama. "Serum electrolytes and lipid profiles in non-insulin dependent diabetes mellitus patients." Asian Journal of Medical Sciences 6, no. 3 (October 10, 2014): 38–41. http://dx.doi.org/10.3126/ajms.v6i3.11088.

Full text

Abstract:

Background: Diabetes mellitus and hyperlipidemia are the most common metabolic disorder affecting the people all over the world. Hyperglycemia is considered a primary cause of diabetic vascular complications and is associated with impaired electrolytes in some of the metabolic dysfunctions is not clear. Aim: The purpose of this study was conducted to investigate the relationship among diabetes mellitus, lipid profiles and electrolytes (Na+, K+ and Cl-). Methods: In the sera of 85 non insulin-dependent diabetes mellitus NIDDM, 45 with hyperlipidemia, 40 without hyperlipidemia, 50 samples of hyperlipidemia without NIDDM, and 50 non diabetic healthy control subjects. The mean age of the diabetic patients was similar to that of control. The mean duration of the disease was (10.2±5.9) years (2-23) years. From the results, it was discovered that there was a significant decrease in Na+ and Cl- in patients with NIDDM without high level of lipid profile (group I), but our results show that the concentration of K+ not changed significantly. The plasma levels of Na+ and Cl- ions were show significant change in patient with hyperlipidemia without NIDDM (group II), while plasma K+ not changed significantly in this group as compared with control. The mean value of Na+ and Cl- show high significant change in NIDDM patients with high level of lipids profile (group III),were plasma K+ not changed significantly as compared with control group. Conclusion: These finding may explain the role of impaired electrolytes status in NIDDM and hyperlipidemia subjects. DOI: http://dx.doi.org/10.3126/ajms.v6i3.11088Asian Journal of Medical Sciences Vol.6(3) 2015 38-41

APA, Harvard, Vancouver, ISO, and other styles

44

Durgarao, Y., Poornima A. Manjrekar, Prabha Adhikari, M. Chakrapani, and M. S. Rukmini. "Comprehensive Review on Diabetes Associated Cardiovascular Complications - The Vitamin D Perspective." Cardiovascular & Hematological Disorders-Drug Targets 19, no. 2 (July 5, 2019): 139–53. http://dx.doi.org/10.2174/1871529x19666190114155302.

Full text

Abstract:

Vitamin D, a steroid hormone is primarily known for its role in calcium and bone mineral homeostasis. Over the years, vitamin D has been implicated in various non-skeletal diseases. The extraskeletal phenomenon can be attributed to the presence of vitamin D receptors (VDRs) in almost all cells and identification of 1-α hydroxylase in extrarenal tissues. The vitamin D deficiency (VDD) pandemic was globally reported with increasing evidence and paralleled the prevalence of diabetes, obesity and cardiovascular diseases (CVDs). A dependent link was proposed between hypovitaminosis D glycemic status, insulin resistance and also the other major factors associated with type 2 diabetes leading to CVDs. Insulin resistance plays a central role in both type 2 diabetes and insulin resistance syndrome. These 2 disorders are associated with distinct etiologies including hypertension, atherogenic dyslipidemia, and significant vascular abnormalities that could lead to endothelial dysfunction. Evidence from randomised clinical trials and meta-analysis, however, yielded conflicting results. This review summarizes the role of vitamin D in the regulation of glucose homeostasis with an emphasis on insulin resistance, blood pressure, dyslipidaemia, endothelial dysfunction and related cardiovascular diseases and also underline the plausible mechanisms for all the documented effects.

APA, Harvard, Vancouver, ISO, and other styles

45

Okunade, Gbolahan W., Odutayo O. Odunuga, and Olufunso O. Olorunsogo. "Iron-Induced Oxidative Stress in Erythrocyte Membranes of Non-Insulin-Dependent Diabetic Nigerians." Bioscience Reports 19, no. 1 (February 1, 1999): 1–9. http://dx.doi.org/10.1023/a:1020113121995.

Full text

Abstract:

The presence of higher level of endogenous free radical reaction products in the erythrocyte ghost membrane (EGM) of Non-insulin-dependent diabetes mellitus (NIDDM) subjects compared with that of normal healthy controls has been demonstrated. The EGMs of NIDDM subjects were also shown to be more susceptible to exogenously generated oxidative stress than those of normal healthy individuals. The decreased level of reactive thiol groups in the EGM of NIDDM individuals supported this observation. We propose that the presence of significant levels of non-heme iron in the EGM of NIDDM subjects is an indication of the potential for iron-catalysed production of hydroxy and other toxic radicals which could cause continuous oxidative stress and tissue damage. Oxygen free radicals could therefore be responsible for most of the erythrocyte abnormalities associated with non-insulin-dependent diabetes and could indeed be intimately involved in the mechanism of tissue damage in diabetic complications.

APA, Harvard, Vancouver, ISO, and other styles

46

Cerveny, Joli D., Rachel D. Leder, and C. Wayne Weart. "Issues Surrounding Tight Glycemic Control in People with Type 2 Diabetes Mellitus." Annals of Pharmacotherapy 32, no. 9 (September 1998): 896–905. http://dx.doi.org/10.1345/aph.17375.

Full text

Abstract:

OBJECTIVE: To review the prospective evidence surrounding the issue of tight glycemic control in people with type 2 diabetes mellitus and resultant long-term complications. DATA SOURCE: Conference proceedings and a MEDLINE search (1966–February 1998) identified pertinent English-language publications on type 2 diabetes in humans. Key search terms included insulin resistance, diabetes mellitus, non-insulin-dependent, macrovascular complications, microvascular complications, and intensive glycemic control. STUDY SELECTION: Selection of prospective epidemiologic and clinical studies were limited to those focusing on the management of type 2 diabetes. All articles with pertinent information relevant to the scope of this article were reviewed. DATA SYNTHESIS: The pathophysiology of type 1 and type 2 diabetes differ; however, both share chronic complications that significantly affect morbidity and mortality. People with type 1 diabetes have an absolute deficiency of insulin, whereas people with type 2 diabetes have varying degrees of insulin resistance and an inadequate compensatory insulin secretory response. The Diabetes Control and Complications Trial (DCCT) has clearly indicated that intense control of blood glucose in type 1 diabetes prevents and slows the progression of microvascular (i.e., retinopathy, nephropathy) and neuropathic complications. The Kumamoto study showed similar results in nonobese patients with type 2 diabetes. Intense insulin therapy in both populations has proven advantageous, thus supporting a common pathophysiologic process for the microvascular and neuropathic complications. Trends were seen toward fewer macrovascular (atherosclerotic disease) complications in the intensive insulin arm of the DCCT. Conversely, trends were seen toward an increase in macrovascular complications in the VA Cooperative study in people with type 2 diabetes using intensive insulin therapy. This may suggest a discordance in the pathophysiology of macrovascular disease between type 1 and type 2 diabetes. Additionally, it remains uncertain whether tight glycemic control prevents the onset or slows the progression of macrovascular disease. Two studies (the University Group Diabetes Program and the Veterans Affairs Cooperative Study on Glycemic Control and Complications in Type 2 Diabetes) to date have examined pharmacotherapy options for patients with type 2 diabetes and resultant macrovascular complications. It has yet to be determined whether any therapeutic intervention will decrease the morbidity and mortality of macrovascular disease in this population. CONCLUSIONS: In type 2 diabetes, limited prospective evidence does support tight glycemic control to help prevent or slow the progression of microvascular and neuropathic complications. It is uncertain whether tight glycemic control decreases macrovascular complications and which pharmacotherapeutic agent(s) is/are the best options. However, therapy that improves glucose control in combination with aggressive risk factor management should be initiated and enforced in patients with type 2 diabetes in an effort to reduce long-term complications.

APA, Harvard, Vancouver, ISO, and other styles

47

BAJRAKTARI, G. "P1148 Left-ventricular diastolic dysfunction and other complications in asymptomatic non-insulin-dependent diabetes mellitus patients." European Heart Journal 24, no. 5 (March 2003): 212. http://dx.doi.org/10.1016/s0195-668x(03)94440-x.

Full text

APA, Harvard, Vancouver, ISO, and other styles

48

Serrano Rios. "Relationship between obesity and the increased risk of major complications in non-insulin-dependent diabetes mellitus." European Journal of Clinical Investigation 28 (September 1998): 14–18. http://dx.doi.org/10.1046/j.1365-2362.1998.0280s2014.x.

Full text

APA, Harvard, Vancouver, ISO, and other styles

49

Cheung, C. K., C. S. Cockram, V. T. Yeung, and R. Swaminathan. "Urinary excretion of transferrin by non-insulin-dependent diabetics: a marker for early complications?" Clinical Chemistry 35, no. 8 (August 1, 1989): 1672–74. http://dx.doi.org/10.1093/clinchem/35.8.1672.

Full text

Abstract:

Abstract We measured concentrations of transferrin (TRF, in micrograms), and creatinine (Cr, in millimoles) in samples of untimed urine from 53 healthy subjects and 157 non-insulin-dependent diabetic (NIDD) subjects. The urinary TRF/Cr ratio was significantly higher in the NIDD group (P less than 0.001). If NIDD subjects are grouped according to their Alb/Cr ratio into normal albuminuria (Group A, Alb/Cr less than 2.5 mg/mmol), microalbuminuria (Group B, Alb/Cr 2.5-26.8 mg/mmol), and macroalbuminuria (Group C, Alb/Cr greater than 26.8 mg/mmol), the TRF/Cr ratios in all three groups exceeded those for healthy controls. Moreover, this ratio was higher in Group B than in Group A and higher in Group C than in Group B. The value for TRF/Cr was clearly abnormal (i.e., exceeded the 95th percentile value found in healthy subjects) in 61%, 95%, and 100% of Group A, B, and C subjects, respectively. The TRF/Cr ratio was significantly higher in those NIDD subjects with clinical retinopathy, and it correlated with arterial pressure. Evidently, TRF/Cr may be increased early in NIDD subjects, and it may be a sensitive marker for detecting development of complications of diabetes.

APA, Harvard, Vancouver, ISO, and other styles

50

Crăciun, Cristian-Ioan, Anca-Elena Crăciun, Adriana Rusu, Corina Ioana Bocşan, Nicolae Hâncu, and Anca Dana Buzoianu. "Increased glycemic variability in type 2 diabetes patients treated with insulin - a real-life clinical practice, continuous glucose monitoring (CGM) study." Revista Romana de Medicina de Laborator 26, no. 3 (July 1, 2018): 345–52. http://dx.doi.org/10.2478/rrlm-2018-0010.

Full text

Abstract:

Abstract Chronic hyperglycemia is an important cause for the development of chronic complications of diabetes, but glycemic variability has emerged in recent years as an independent contributor to diabetes-related complications. Our objective was to evaluate glycemic variability in patients with T2DM treated with insulin compared with other antidiabetic drugs. In this retrospective study, we collected 24-hour continuous glucose monitoring (CGM) recording data from 95 patients with T2DM, of which 27 treated with insulin and 68 with non-insulin treatment. We calculated and compared 16 glucose variability parameters in the insulin-treated and non-insulin treated groups. Insulin treated patients had significantly higher values of parameters describing the amplitude of glucose value fluctuations (standard deviation of glucose values, percentage coefficient of variation [%CV], and mean amplitude of glycemic excursion [MAGE], p <0.05) and time-dependent glucose variability (percentage of time with glycemic values below 70 mg/dl and continuous overall net glycemic action [CONGA] at 2, 4 and 6 hours, p <0.05). In conclusion, insulin therapy in T2DM is correlated with significantly higher glycemic variability.

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!