Relevant bibliographies by topics / Non-homosexual

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers

Academic literature on the topic 'Non-homosexual'

Author: Grafiati
Published: 4 June 2021
Last updated: 2 February 2022

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Journal articles on the topic "Non-homosexual"

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Blanchard, Ray, and Peter M. Sheridan. "Proportion of Unmarried Siblings of Homosexual and Non Homosexual Gender-Dysphoric Patients*." Canadian Journal of Psychiatry 37, no. 3 (April 1992): 163–67. http://dx.doi.org/10.1177/070674379203700303.

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Among the siblings of homosexuals, a lack of sexual and romantic interest in women may be independent of erotic feelings for men. This study investigated the sexual histories of siblings of gender-dysphoric outpatients. The patients were classified into three groups: non homosexual males, homosexual males and homosexual females. Their siblings consisted of 301 brothers and 284 sisters over the age of 25. Logistic regression showed that the brothers of the homosexual male patients were significantly less likely to have been married, either legally or common-law, than the brothers of the other gender-dysphoric groups, even with age and relative birth order taken into account. This finding suggests that the low propensity for long term heterosexual relationships seen in homosexual male gender-dysphoric patients also tends to appear in their brothers.
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Carr, N. D., D. Mercey, and W. W. Slack. "Non-condylomatous perianal disease in homosexual men." British Journal of Surgery 76, no. 10 (October 1989): 1064–66. http://dx.doi.org/10.1002/bjs.1800761026.

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Nuttbrock, Larry, Walter Bockting, Mona Mason, Sel Hwahng, Andrew Rosenblum, Monica Macri, and Jeffrey Becker. "A Further Assessment of Blanchard’s Typology of Homosexual Versus Non-Homosexual or Autogynephilic Gender Dysphoria." Archives of Sexual Behavior 40, no. 2 (December 29, 2009): 247–57. http://dx.doi.org/10.1007/s10508-009-9579-2.

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Kalter, SP, SA Riggs, F. Cabanillas, JJ Butler, FB Hagemeister, PW Mansell, GR Newell, WS Velasquez, P. Salvador, and B. Barlogie. "Aggressive non-Hodgkin's lymphomas in immunocompromised homosexual males." Blood 66, no. 3 (September 1, 1985): 655–59. http://dx.doi.org/10.1182/blood.v66.3.655.655.

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Abstract During the period from 1981 through 1984, 14 immunocompromised homosexual males with intermediate or high-grade non-Hodgkin's lymphoma were seen at University of Texas M.D. Anderson Hospital and Tumor Institute. Six patients had diffuse large-cell lymphoma, seven had diffuse undifferentiated lymphoma, and one had unclassifiable lymphoma that suggested large-cell lymphoma. Eight patients had the acquired immunodeficiency syndrome (AIDS) and five had the AIDS-related complex. Kaposi's sarcoma was initially present in four patients and developed later in two others. The patients with diffuse large-cell lymphoma were characterized by more severely altered immune parameters, multicentric brain mass lesions, pretherapy opportunistic infections, lower performance status, poor response to therapy, and death in all within six months. The undifferentiated lymphoma group had preceding generalized reactive lymphadenopathy, less severe immune dysfunction, and excellent response to combination chemotherapy, with survival time greater than 19 months in three patients. Twelve of the patients had extranodal sites of lymphoma at presentation. There is a definite trend for the development of aggressive non-Hodgkin's lymphomas with unusual sites of extranodal involvement in immunocompromised homosexual males, with the potential for good tolerance to combination chemotherapy and improved survival in the subgroup without severe concomitant opportunistic infections.
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Kalter, SP, SA Riggs, F. Cabanillas, JJ Butler, FB Hagemeister, PW Mansell, GR Newell, WS Velasquez, P. Salvador, and B. Barlogie. "Aggressive non-Hodgkin's lymphomas in immunocompromised homosexual males." Blood 66, no. 3 (September 1, 1985): 655–59. http://dx.doi.org/10.1182/blood.v66.3.655.bloodjournal663655.

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During the period from 1981 through 1984, 14 immunocompromised homosexual males with intermediate or high-grade non-Hodgkin's lymphoma were seen at University of Texas M.D. Anderson Hospital and Tumor Institute. Six patients had diffuse large-cell lymphoma, seven had diffuse undifferentiated lymphoma, and one had unclassifiable lymphoma that suggested large-cell lymphoma. Eight patients had the acquired immunodeficiency syndrome (AIDS) and five had the AIDS-related complex. Kaposi's sarcoma was initially present in four patients and developed later in two others. The patients with diffuse large-cell lymphoma were characterized by more severely altered immune parameters, multicentric brain mass lesions, pretherapy opportunistic infections, lower performance status, poor response to therapy, and death in all within six months. The undifferentiated lymphoma group had preceding generalized reactive lymphadenopathy, less severe immune dysfunction, and excellent response to combination chemotherapy, with survival time greater than 19 months in three patients. Twelve of the patients had extranodal sites of lymphoma at presentation. There is a definite trend for the development of aggressive non-Hodgkin's lymphomas with unusual sites of extranodal involvement in immunocompromised homosexual males, with the potential for good tolerance to combination chemotherapy and improved survival in the subgroup without severe concomitant opportunistic infections.
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Wilson, A. P. R., A. EfstratiouE Weaver, E. Allason-Jones, J. Bingham, A. Robinson, G. Colman, G. L. Ridgway, D. Mercey, and B. D. Cookson. "Unusual non-toxigenic Corynebacterium diphtheriae in homosexual men." Lancet 339, no. 8799 (April 1992): 998. http://dx.doi.org/10.1016/0140-6736(92)91583-t.

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McGeary, Rebecca, and Kate Fitz-Gibbon. "The homosexual advance defence in Australia: An examination of sentencing practices and provocation law reform." Australian & New Zealand Journal of Criminology 51, no. 4 (January 11, 2018): 576–92. http://dx.doi.org/10.1177/0004865817749261.

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In May 2015, the judgment of the High Court of Australia in Lindsay v The Queen reignited debate surrounding the use of the partial defence of provocation in cases involving a non-violent homosexual advance. Lindsay re-established the legal possibility that a man provoked enough to lose self-control and commit lethal violence in response to a non-violent homosexual advance could be convicted of manslaughter by reason of provocation rather than murder. The judgment arrived in the midst of two decades of national law reform activity, whereby all Australian jurisdictions have either introduced or proposed reform to abolish or restrict the application of the controversial partial defence of provocation. In doing so, cases involving a homosexual advance defence are increasingly shifting to the realm of sentencing. This article offers a timely analysis of the sentencing of homosexual advance defence cases in New South Wales and Queensland. In doing so, it examines the judicial treatment of a defendant’s claim of a ‘special sensitivity’ to a homosexual advance, problems arising from the private nature of an alleged homosexual advance and the treatment of intoxication in sentencing. It reveals that reform of legal categories alone may not be sufficient in ensuring a just legal response to homicides incited by alleged homosexual advances.
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Burns, R. A., P. Butterworth, and A. F. Jorm. "The long-term mental health risk associated with non-heterosexual orientation." Epidemiology and Psychiatric Sciences 27, no. 1 (December 8, 2016): 74–83. http://dx.doi.org/10.1017/s2045796016000962.

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Aims.Findings that describe the mental health risk associated with non-heterosexual orientation in young and middle-aged adults are from cross-sectional designs or fail to discriminate homosexual and bisexual orientations. This study examines the mental health risk of homosexual and bisexual orientation over an 8-year period.Methods.Participants were from the age-cohort study, the Personality and Total Health Through Life Project, were observed twice every 4 years, and aged 20–24 (n = 2353) and 40–44 (n = 2499) at baseline.Results.Homosexual orientation was unrelated to long-term depression risk. Risk for anxiety and depression associated with homosexual and bisexual orientations, respectively, were attenuated in fully-adjusted models. Bisexual orientation risk associated with anxiety was partially attenuated in fully-adjusted models.Conclusions.Non-heterosexual orientation was not a major risk factor for long-term mental health outcomes. Instead, those with a non-heterosexual orientation were more likely to experience other mental health risk factors, which explain most of the risk observed amongst those with a non-heterosexual orientation.
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Dixon, L., S. Pearson, and D. J. Clutterbuck. "Chlamydia trachomatis infection and non-gonococcal urethritis in homosexual and heterosexual men in Edinburgh." International Journal of STD & AIDS 13, no. 6 (June 1, 2002): 425–26. http://dx.doi.org/10.1258/095646202760029877.

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In 1998, when ligase chain reaction testing for chlamydial infection was introduced in our clinic in Edinburgh, routine clinic protocol included the testing of all heterosexual, but not homosexual, men for urethral chlamydial infection. We audited all new homosexual and bisexual male attendees with a diagnosis of chlamydial infection or non-gonococcal urethritis (NGU) in 1999, together with heterosexual men with the same diagnoses attending in alternate months of the same year. Urethral Chlamydia trachomatis infection was detected in 14.6% (350/2402) of heterosexual men and 2.4% (11/465) of homosexual men tested. Fifty percent of chlamydial infections were asymptomatic. In this population 44% (84/190) of NGU in heterosexual men is attributable to C. trachomatis as opposed to only 10% (6/59) of that in homosexual men. These rates of chlamydial infection differ from previous reports in Scotland and recent studies from the USA. Our clinic protocol has been revised to include routine testing for chlamydial infection in all men.
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Bradfield, Rebecca. "Provocation and Non-Violent Homosexual Advances: Lessons from Australia." Journal of Criminal Law 65, no. 1 (February 2001): 76–84. http://dx.doi.org/10.1177/002201830106500107.

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Dissertations / Theses on the topic "Non-homosexual"

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Parsonson, Ian Malcolm, and kimg@deakin edu au. "SYPHILIS AND AIDS: HISTORICAL AND SOCIAL COMPARISONS." Deakin University. School of Humanities, 1992. http://tux.lib.deakin.edu.au./adt-VDU/public/adt-VDU20031118.111824.

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Drawing on the literatures of history, sociology, epidemiology, and microbiology, this thesis compares syphillis with human immunodeficiency virus, with special reference to the social and historical factors likely to be relevant to the control or eradication of acquired imune dificiency syndrom (AIDS). The sudden appearance of a new disease causing suffering and death in a community, engenders apprehension and fear which is often manifested as hysteria against, and vilification of, those who have the disease. This fear is greatly increased should the disease be sexually-transmitted. Syphilis in a venereal form, occured in Europe toward the end of the 15th Century. Initially it was an acute, fulminating disease which rapidly spread through Europe and Asia. Attempts to control the disease have gone through periods of either partial successes or massive failures and have ended in frustration for the authorities. When the syndrome of acquired immune deficiency (AIDS) was first reported, it was seen in Western countries in homosexual men. However, as non-homosexual community members and children became infected, it became apparent to authorities that a pandemic was accurring. Within a few years, the disease was identified worldwide. Isolation of the virus (HIV-1), and development of test for detection of carriers, plus restoration of clean blood and blood-product supplies, have reassured the community to some extent. The history of syphilis shows that neither the epidemiological medical, nor the economic political approaches to disease control work, although there are positive aspects resulting from both. It is social responses that will offer the most hope in the long term for the control of AIDS and other sexually-transmitted diseases.
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Byers, Kenneth Morton. "Valued occupational roles and life satisfaction among south Florida HIV-infected and Non-infected homosexual males : an exploratory study." FIU Digital Commons, 1997. http://digitalcommons.fiu.edu/etd/2003.

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A study was conducted in order to describe and understand the occupational role behavior of gay men with particular interest on understanding the impact of an HIV diagnosis on their roles and life satisfaction. A 137- item questionnaire was developed for this study and distributed through various gay community groups in south Florida. The process resulted in ranked description of 24 valued occupational roles of gay men (n = 80) along with a general understanding of potential shifts that may occur in those roles as a result of becoming infected with HIV. The study concludes that a diagnosis of HIV infection impacts gay men both by altering their value for particular roles and by darkening the images they hold of their future. The study also identified key factors which may contribute to the greater life satisfaction of gay men including greater confidence in personal knowledge of HIV, a more optimistic outlook on life, the use of stronger coping styles, and perceiving stronger social support and lower stress.
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McCormick, Tracey Lee. "Discourse and politics in the production of homosexual subjectivities in South Africa: a queer theory analysis of selected English non-fiction texts (1992-2008)." Thesis, 2012. http://hdl.handle.net/10539/11881.

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Ph.D. University of the Witwatersrand, Faculty of Humanities, 2012
In this thesis I argue that the current contradiction between the constitutional rights of gay and lesbian people in South Africa and the daily, continual experiences of homophobic violence and discrimination necessitates an alternative analysis of the contradictory nature of gay and lesbian rights in South Africa. In order to do this, I draw on Queer Theory to analyse the link between discourse and politics in the production of homosexual subjectivities in six South African English non-fiction books between1992 and 2008that have never before been the focus of a dedicated research investigation.I cover this period because it encompasses various epochs in which the shift in the priorities and issues on the gay and lesbian rights agenda can be identified and in which the evolving image of the public face of homosexuality can be mapped. The unique South African political and historical contexts in which each book was written is central to understanding the specificity of gay and lesbian identity construction. I draw on Queer Theory (Foucault, Butler, Rubin) as a critical hermeneutic which has as its aim to provide insight into the complexity of identity and difference from a poststructuralist point of view in order to analyse the link between discourse and the production of subjectivity. In my analysis of the six non-fiction texts I demonstrate how representations of gay and lesbian identities vary depending on the political imperatives of the gay and lesbian movement and the level of homophobia that existed at the time of the production of each text under investigation. I make evident those instances where Queer Theory is useful as an analytical tool for examining identity and difference, and where it is not in the South African context. I point out the limitations of an identity politics approach to understanding and resisting discrimination against gay, lesbian and queer people. Finally, I argue that from a Queer Theory perspective, rights based and identity politics approaches to political change have the potential for the assimilation of difference into a normative paradigm.
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Books on the topic "Non-homosexual"

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Catholic Church. Congregatio pro Doctrina Fidei. Non-discrimination against homosexual persons: Some considerations concerning the response to legislative proposals. Boston, MA: St. Paul Books & Media, 1990.

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Kosstrin, Hannah. Queer Spaces in Anna Sokolow’s Rooms. Oxford University Press, 2017. http://dx.doi.org/10.1093/acprof:oso/9780199377329.003.0008.

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Celebrated for its themes of postwar alienation, Anna Sokolow’s Rooms (1954) also subverts 1950s expectations for gendered and sexualized bodies onstage. Rooms’ vignettes reveal queerness through dancers’ feelings of isolation and expressions of normative and queer desire, panic, unrequited love, absent lovers, and contemplations of suicide. These queer spaces include moments of homosexual longing and moments of non-conforming heterosexuality that undermine normalcy and lead to a reconsideration of Rooms’ function within early Cold War politics. This essay posits that the tension between queer and universal representation in Rooms invokes the 1950s climate of fear that caused gay people to live closeted lives under the threat of persecution. Through reading Rooms as a queer text within the context of the Lavender Scare, this essay shows how queer lives were central to the general marginalized experience Sokolow presented in this dance, and how through presentations like Rooms queerness defined the 1950s mainstream.
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Book chapters on the topic "Non-homosexual"

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Meek, Jeffrey. "Non-Heterosexual Men, Scotland and Homosexual Law Reform." In Queer Voices in Post-War Scotland, 187–91. London: Palgrave Macmillan UK, 2015. http://dx.doi.org/10.1057/9781137444110_9.

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Riggs, S. A., S. Kalter, F. Cabanillas, F. B. Hagemeister, W. S. Velasquez, B. Barlogie, P. Salvador, P. Mansell, E. Hersh, and J. Butler. "Unusual presentations of non-Hodgkin’s lymphomas in homosexual males." In Malignant Lymphomas and Hodgkin’s Disease: Experimental and Therapeutic Advances, 261–67. Boston, MA: Springer US, 1985. http://dx.doi.org/10.1007/978-1-4613-2607-6_27.

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"NON-LINEAR STOCHASTIC MODELS IN HOMOSEXUAL POPULATIONS." In Stochastic Processes in Epidemiology, 357–444. WORLD SCIENTIFIC, 2000. http://dx.doi.org/10.1142/9789812779250_0010.

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Provencher, Denis M. "Abdellah Taïa’s Queer Moroccan Family and Transmission of Baraka." In Queer Maghrebi French. Liverpool University Press, 2018. http://dx.doi.org/10.5949/liverpool/9781781383001.003.0005.

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In this chapter, I conduct an analysis of language, temporalities, transfiliations, and baraka (meaning “luck,” “chance,” “blessings” or what I’ll call “knowledge”) in the life and work of Abdellah Taïa, one of the first Moroccan authors to write publicly about his own homosexuality and to depict homosexual Moroccan protagonists alongside a variety of other queer and non-queer characters in his autofiction.
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Mack, Mehammed Amadeus. "The Banlieue Has a Gender: Competing Visions of Sexual Diversity." In Sexagon. Fordham University Press, 2017. http://dx.doi.org/10.5422/fordham/9780823274604.003.0002.

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This chapter examines the various ways journalists and activists who purport to fight for sexual diversity have actually reified sexual conformism through two processes: the demonization of the banlieue’s racialized, non-normative sexualities and the willful denial of the banlieue’s queer potential. In journalism, investigative reports, and interventions on the ground, commentators purporting to represent gay and feminist interests have focused on an uncommonly sexist banlieusard virility, with alleged roots in Islamic cultures. This process fits into a larger, more familiar one, in which immigration from the former colonies has been sexualized, with concerns articulated around men’s machismo and women’s subjugation. In recent years, respect for sexual minorities has constituted a new frontier for campaigns targeting banlieue attitudes and behaviors. In this vein, some campaigns purporting to “defend” have taken the form of attacks. Rhetoric about “saving” banlieue women and homosexuals has exoticized the banlieues as inhospitable and lawless zones worthy of human rights intervention. At the same time that it defines the homosexual victim, this rhetoric also determines the “appropriate” expression of homosexual identity or practices.
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Parker, Sarah. "The Male Wound in Fin-de-Siècle Poetry." In The Male Body in Medicine and Literature, 87–102. Liverpool University Press, 2018. http://dx.doi.org/10.3828/liverpool/9781786940520.003.0006.

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This essay fixes on the figure of Saint Sebastian as the ‘icon for the literally and metaphorically penetrable male body in the late nineteenth century’. Sarah Parker regards him as a focus for the aesthetic and decadent impulses of the fin de siècle, particularly appealing to non-heteronormative sexualities, but also as a contrasting exemplum for degeneration discourse. Sebastian’s prevalence in the literature of the late nineteenth century, Parker argues, codifies a nascent aesthetics of homosexual suffering while at the same time offering a provocative metaphorisation of sodomitic activity. It further articulates same-sex relationships with the religious tradition of suffering, producing strikingly eroticised poetry that fantasises about penetrating the wounds not only of Sebastian but also of Christ.
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Stoner, Andrew E. "Becoming the AIDS Scribe." In The Journalist of Castro Street, 89–110. University of Illinois Press, 2019. http://dx.doi.org/10.5622/illinois/9780252042485.003.0007.

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Shilts joins The San Francisco Chronicle as its first openly gay reporter on the newsroom staff. Hired to cover the “gay beat” in San Francisco, Shilts also is given general assignment stories. Shilts coordinates Chronicle coverage of the deadly October 1989 Loma Prieta earthquake. Newsroom colleagues overcome suspicions of the new “gay reporter” as Shilts lobbies publishers for non-discrimination policies and domestic partner benefits. Shilts picks up on rumors of a “gay cancer” affecting gay men in the Castro district. Reporting includes very first stories attempting to link exotic immune system related diseases with homosexual men in San Francisco and elsewhere. Shilts is becomes convinced the AIDS story is a major story and devotes himself nearly full-time to the subject.
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"Lacan and the Homosexual Young Woman:." In A Non-Oedipal Psychoanalysis?, 109–20. Leuven University Press, 2012. http://dx.doi.org/10.2307/j.ctt9qf0fn.10.

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Zanarini, Mary C. "Sexual Issues over Time." In In the Fullness of Time, 175–80. Oxford University Press, 2018. http://dx.doi.org/10.1093/med-psych/9780195370607.003.0017.

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We studied two types of sexual issues over time. The first issue was sexual relationship difficulties, which we defined as avoiding sex for fear of becoming symptomatic, or becoming symptomatic after having sex. The second issue was sexual orientation and gender of relationship choice. At six-year follow-up, we found that sexual relationship difficulties were significantly more common among borderline patients than among Axis II comparison subjects, although the rate was declining in both study groups. At 16-year follow-up, the same pattern was found for non-recovered versus recovered borderline patients. In terms of the second issue, patients with BPD were significantly more likely than Axis II comparison subjects to report homosexual or bisexual orientation and intimate same-sex relationships. In addition, patients with BPD were significantly more likely than Axis II comparison subjects to report changing the gender of intimate partners, but not sexual orientation, at some point during the follow-up period.
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Watkins, Jerry T. "Emma Jones." In Queering the Redneck Riviera. University Press of Florida, 2018. http://dx.doi.org/10.5744/florida/9780813056913.003.0006.

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Economic expansion and ideas about the free market had a profound impact on what magazines and books could print as well as distribute, which meant that queer folk in far-flung places could gain access to information about homosexuality, civil rights activity, and identity-based discourses. They could become part of the national imagined community of gays and lesbians. In Pensacola, “adopted brothers” and lifelong lovers Ray and Henry Hillyer had a desire to keep abreast of the latest news and other homosexual happenings. The started a small book club in their home under the cover of a non-descript name Emma Jones that by 1974 had grown into a weekend-long convention with beach parties and patriotic drag shows at the San Carlos Hotel that drew thousands to the beaches of Pensacola. When queer visibility threatened Pensacola tourism, bars were raided, arrests were made, and Emma’s party was cancelled. Partying does not always lead to political action, but creating a space for gay men and lesbians to feel at ease with themselves is a profoundly political act. By deploying their bodies and their dollars, the Emma Jones Society established an LGBT presence in “The Sunshine State.”
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Conference papers on the topic "Non-homosexual"

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Lefrere, J. J., D. Vittecoq, D. Gozin, and J. Modai. "CIRCULATING ANTICOAGULANT IN AIDS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644859.

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The frequency of a circulating anticoagulant has been reported to be high in AIDS, in particular in case of Pneumocystic carinii pneumonia (Pep). Twenty-five non-hemophiliac patients (23 homosexual males,1 drug addict, 1 tranfused) with AIDS were followed over a six month period. Mean age was 32 (21-42). All patients had a markedly decreased T4/T8 ratio (mean 0.12), a low absolute T4 level (mean : 155/mm3), an elevated total serum immunoglobulins level.Activated partial thromboplastin time (APTT), prothrombintime and thrombin time were measured once a week during hospitalisation. A prolonged APTT (more than 10 seconds as compared to controls) with normal prothrombin time and thrombin time was found only once in 11patients and in two or more occasions in two others.No specific factor level of intrinsic pathway wasfound low enough to explain a prolonged APTT.Evidenceofcirculating anticoagulant (failure to correct aprolonged APTT by equal mixure of normal plasma and patient plasma) was found in all these 13 patients.Nothrombotic or haemorraghic manifestations occured.AIDS manifestations were 2 Pep.1 cytomegalovirus retinitis. 2 Kaposi's sarcomas, 1 Hodgkin's disease, 2 mycobacterium avium intracellulare pulmonary infection, 4 central nervous system toxoplasmosis, 1 Cryptococcus meningitis. Amongst the 12 patients with normal APTT,3_Pcp, 2 cytomegalovirus retinitis. 2 Kaposi's sarcomas, 2 central nervous system toxoplasmosis, 1 unexplained fever, and 2 oesophagus candidiasis were diagnosed. A transiently prolonged APTT associated to a circulating inhibitor seems to be common in AIDS. Weobserved this anomaly in 52 % (13/25). In our five cases of Pcp, 3 had normal APTT. During other opportunistic infections, the circulating inhibitor was found.The similar complications seen in two groups suggest that a circulating anticoagulant is not specifically associated to any opportunistic infection and any malignancybut appearr independently from these circumstances.
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WAJIMA, T. "THROMBOCYTOPENIA IN ACQUIRED IMMUNE DEFICIENCY SYNDRGME(AIDS)-RELATED COMPLEXES:RESOLUTION DURING HERPES VIRAL INFECTION." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644145.

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Immune thrombocytopenia has been recognized as a major hematologic manifestation associated with the acquired immune deficiency syndrome(AIDS) and AIDS-related complexes. The mechanism of thrombocytopenia in human immune deficiency virus infection is probably multifactorial.. The role of platelet-associated immuno-globulin(PAIgG)and circulating immune complexes(CIC) in mediating thrombocytopenia is controversial.. We experienced a case in which immune thrombocytopenia in AIDS-related complexes resolved during herpes zoster infection. A 37 y.o. white homosexual male with AIDS-related complexes and thrombocytopenia presented a 4-day history of painful, violaceous, non-pruritic vesicles which started on the right arm and hand, which then progressed to the chest wall, abdomen, back, and left arm. Peripheral lymphadenop-athy and splenomegaly was not noted. On admission WBG 13.5 Hct 40.8, platelet 46,000, Tzanck smear of vesicles revealed herpetic type giant cells. HTLV-III pos., Helper/suppressor T-cell ratio 0.3, Total protein 7.9 gm%, . Alb 3.95gm% IgG 1740 mg%, IgA 157 mg IgM 91.2 mg, Monospot neg., HBsAg Neg., HBsAb pos., HBcAb pos., VDRL neg. Before this admission, immune thrombocytopenia was documented by increased levels of PAIgG, CIC, bone marrow magakaryocytic hyperplasia, peripheral thrombocytopenia with giant platelets, absence of splenomegaly, and response to prednisone. He was treated with Acyclovir 250 mg/m2 1-hr infusion Q8h for 9 days ;to control the spread of his herpes infection. Recovery of thrombocytopenia wasobserved during herpes zo.ster infection. The platelet count rose to 158,000 and sustained over 4- weeks. Duringnormalization of platelet count thelevel of GIC (assayed by Raji cells, reference ranges, less than 12) droppedfrom 300 to less than 12 and PAIgG(fluorescence-activated flow cytometric assay, reference ranges, less than 1.5 RF) was markedly decreased from 90 to 2.9 When herpes infection had subsided the platelet count again decreased. These findings suggestthat PAIgG and GIG were contributing factors to immune thrombocytopenia and that herpes viral infection and Acyclovir altered this immunologically mediated thrombocytopenia in AIDS-related complexes.
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