Academic literature on the topic 'Non-conventional development'
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Journal articles on the topic "Non-conventional development"
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Bakthavatsalam, V., and D. Chakravarthy Reddy. "Non-Conventional Energy for Rural Development." SEDME (Small Enterprises Development, Management & Extension Journal): A worldwide window on MSME Studies 13, no. 1-2 (June 1986): 35–41. http://dx.doi.org/10.1177/0970846419860105.
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THEODOSIOU, SAVVAS A. "Development of Non-conventional Water Sources in Cyprus." Natural Resources Forum 10, no. 3 (August 1986): 299–301. http://dx.doi.org/10.1111/j.1477-8947.1986.tb00093.x.
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Ogrydziak, David M. "Development of genetic maps of non-conventional yeasts." Journal of Basic Microbiology 28, no. 3 (1988): 185–96. http://dx.doi.org/10.1002/jobm.3620280307.
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Javier-Torrent, Míriam, and Carlos A. Saura. "Conventional and Non-Conventional Roles of Non-Muscle Myosin II-Actin in Neuronal Development and Degeneration." Cells 9, no. 9 (August 19, 2020): 1926. http://dx.doi.org/10.3390/cells9091926.
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Myosins are motor proteins that use chemical energy to produce mechanical forces driving actin cytoskeletal dynamics. In the brain, the conventional non-muscle myosin II (NMII) regulates actin filament cytoskeletal assembly and contractile forces during structural remodeling of axons and dendrites, contributing to morphology, polarization, and migration of neurons during brain development. NMII isoforms also participate in neurotransmission and synaptic plasticity by driving actin cytoskeletal dynamics during synaptic vesicle release and retrieval, and formation, maturation, and remodeling of dendritic spines. NMIIs are expressed differentially in cerebral non-neuronal cells, such as microglia, astrocytes, and endothelial cells, wherein they play key functions in inflammation, myelination, and repair. Besides major efforts to understand the physiological functions and regulatory mechanisms of NMIIs in the nervous system, their contributions to brain pathologies are still largely unclear. Nonetheless, genetic mutations or deregulation of NMII and its regulatory effectors are linked to autism, schizophrenia, intellectual disability, and neurodegeneration, indicating non-conventional roles of NMIIs in cellular mechanisms underlying neurodevelopmental and neurodegenerative disorders. Here, we summarize the emerging biological roles of NMIIs in the brain, and discuss how actomyosin signaling contributes to dysfunction of neurons and glial cells in the context of neurological disorders. This knowledge is relevant for a deep understanding of NMIIs on the pathogenesis and therapeutics of neuropsychiatric and neurodegenerative diseases.
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Kishore, D. Ravi, I. Solomon Raju, G. Chandrasekhar Reddy, and T. J. Prasannamba. "Development of Integrated and Efficient Non Conventional Power Distribution." Indian Journal of Public Health Research & Development 9, no. 12 (2018): 1525. http://dx.doi.org/10.5958/0976-5506.2018.02071.5.
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Zhu, Bin, Guangyao Meng, and Bengt-Erik Mellander. "Non-conventional fuel cell systems: new concepts and development." Journal of Power Sources 79, no. 1 (May 1999): 30–36. http://dx.doi.org/10.1016/s0378-7753(98)00195-5.
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Prieto, J. M. B., and M. J. B. Felippe. "Development, phenotype, and function of non-conventional B cells." Comparative Immunology, Microbiology and Infectious Diseases 54 (October 2017): 38–44. http://dx.doi.org/10.1016/j.cimid.2017.08.002.
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Horai, Reiko, Robin Handon, Christine Broussard, Kristen Mueller, Ana M. Venegas, B. J. Fowlkes, and Pamela L. Schwartzberg. "The Tec kinase Itk regulates conventional versus non-conventional CD8 T cell development (87.14)." Journal of Immunology 178, no. 1_Supplement (April 1, 2007): S130. http://dx.doi.org/10.4049/jimmunol.178.supp.87.14.
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Abstract Mutations affecting the Tec kinases Itk and Rlk impair both positive and negative selection and alter CD4 and CD8 T cell development. We previously demonstrated that mature CD8 SP thymocytes and peripheral CD8 T cells in Itk−/− and Rlk−/−Itk−/− mice do not resemble conventional CD8 T cells. Instead, these cells express memory markers and can be selected on MHC class I expressed on hematopoietic cells, suggesting these cells resemble non-conventional MHC class Ib-selected “innate-type” cells. Indeed, Itk-deficiency increases positive selection on MHC class Ib in the Kb−/−Db−/− background. We further find that either improving TCR signaling with stronger signals orblocking CD28 costimulation, partially corrects memory phenotypes of Itk−/− CD8 T cells, arguing that different strength or quality of signals may lead to development of this distinct CD8 T cell population. Our results suggest that Tec kinases differentially regulate development of conventional versus non-conventional lymphocytes. The requirement for signals from hematopoietic cells for selection of these “innate-type” CD8 T cells in Itk−/− mice will be discussed.
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Rauf, Abdur, Tareq Abu-Izneid, Ahmed Olatunde, Anees Ahmed Khalil, Fahad A. Alhumaydhi, Tabussam Tufail, Mohammad Ali Shariati, et al. "COVID-19 Pandemic: Epidemiology, Etiology, Conventional and Non-Conventional Therapies." International Journal of Environmental Research and Public Health 17, no. 21 (November 4, 2020): 8155. http://dx.doi.org/10.3390/ijerph17218155.
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Coronavirus disease 2019 (COVID-19), which reported in an outbreak in 2019 in Wuhan, Hubei province, China, is caused by the SARS-CoV-2 virus. The virus belongs to the beta-coronavirus class, along with the Middle East Respiratory Syndrome coronavirus and Severe Acute Respiratory Syndrome coronavirus. Interestingly, the virus binds with angiotensin-converting enzyme-2 found in host cells, through the spike (S) protein that exists on its surface. This binding causes the entry of the virus into cells of the host organism. The actual mechanism used by the COVID-19 virus to induce disease is still speculative. A total of 44,322,504 cases, a 1,173,189 death toll and 32,486,703 recovery cases have been reported in 217 countries globally as of 28 October 2020. Symptoms from the infection of the virus include chest pain, fever, fatigue, nausea, and others. Acute respiratory stress syndrome, arrhythmia, and shock are some of the chronic manifestations recorded in severe COVID-19. Transmission is majorly by individual-to-individual through coughing, sneezing, etc. The lack of knowledge regarding the mechanism of and immune response to the virus has posed a challenge in the development of a novel drug and vaccine. Currently, treatment of the disease involves the use of anti-viral medications such as lopinavir, remdesivir, and other drugs. These drugs show some efficacy in the management of COVID-19. Studies are still on-going for the development of an ideal and novel drug for treatment. In terms of natural product intervention, Traditional Chinese Medicines (TCM) have been employed to alleviate the clinical manifestation and severity of the disease and have shown some efficacy. This review presents an updated detailed overview of COVID-19 and the virus, concerning its structure, epidemiology, symptoms and transmission, immune responses, and current interventions, and highlights the potential of TCM. It is anticipated that this review will further add to the understanding of COVID-19 and the virus, hence opening new research perspectives.
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Benevides Magalhães Braga, Tatiana, Bárbara Penteado Cabral, Alessandro de Magalhães Gemino, Marciana Gonçalves Farinha, and Demétrius Alves de França. "Clinical solutions performed in non-conventional settings." JAHR 12, no. 2 (2021): 307–24. http://dx.doi.org/10.21860/j.12.2.6.
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This paper presents the Brazilian specificities of the development of its public health and social assistance policies since the re-democratization process in the 1980s until today. Besides, it presents a wide range of conflicts between the economic interests and the political activism accountable for the advances of the public policies implementation. This evolution is presented as a subsidy to the reader’s understanding of the development of a clinical solution for non-conventional settings specific to the Brazilian social and economic reality. Successful clinical experiences in health and social assistance based on phenomenology are presented, not only for diagnosis purposes, namely for understanding the people, for the context in the question, as well as the successful management development. The first case describes the provision of a peripatetic group therapy service, prior as a walking clinical practice, where the notion of territoriality and the dynamics of group interaction facilitate the understanding of the patients, while the intrinsic condition of the work also facilitates the establishment of transferential relationships. The second case describes the complexity of social welfare policy challenges through the clinical intervention while presenting a family in a social and economic vulnerability context.
Dissertations / Theses on the topic "Non-conventional development"
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Wucher, Tim. "The development of a new orthodontic appliance using non-conventional electromechanical methods." Thesis, Stellenbosch : Stellenbosch University, 2013. http://hdl.handle.net/10019.1/80041.
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Thesis (MScEng)--Stellenbosch University, 2013.ENGLISH ABSTRACT: Orthodontics is the eld of dentistry concerned with the treatment of maloc- clusion and anomalies of the dento-facial complex. This thesis is concerned with studying the underlying biomechanical principles of orthodontic tooth movement. It aims to develop a novel treatment approach and an orthodontic appliance to facilitate said approach by employing advanced technologies. A thorough review of the literature is used to form a comprehensive knowledge base pertaining to the factors a ecting orthodontic tooth movement. It is hypothesised that an electromechanical orthodontic appliance could improve treatment by characterising orthodontic cases based on the relationship be- tween the applied mechanical stimulus and the resulting changes to the af- fected structures, which can then be sensed by the appliance. A prototype is built using electronically controllable linear actuators and a custom built force transducer system for measuring orthodontic forces. Electronic circuits are de- veloped to connect the appliance to a USB port and allow it to be controlled from a graphical user interface (GUI). This further facilitates real-time viewing of important orthodontic parameters. Experiments are carried out to evaluate the appliance functionality with regard to the proposed hypothesis. To con- clude, the relevance of the results to the orthodontic eld is highlighted and recommendations for further development of an electromechanical orthodontic appliance are provided.
AFRIKAANSE OPSOMMING: Ortodonsie is die vakgebied in tandheelkunde gemoeid met die behandeling van wanpassing en abnormaliteit van die tand- en gesig-area. Hierdie tesis bestudeer die onderliggende biomeganiese beginsels van ortodontiese tandbeweging om sodoende 'n nuwe benadering sowel as 'n ortodontiese apparaat te ontwikkel om die genoemde benadering te fasiliteer deur gebruik te maak van gevorderde tegnologie. 'n Deeglike oorsig van die literatuur word gebruik om 'n omvattende kennisbasis op te bou rondom die faktore wat ortodontiese tandbeweging a ekteer. Die hipotese word gestel dat 'n elektromeganiese ortodontiese apparaat behandeling kan verbeter deur ortodontiese gevalle te identi seer/- karakteriseer gebaseer op die verhouding tussen die toegepaste meganiese stimulus en die gevolglike veranderinge aan die gea ekteerde strukture wat deur die apparaat aangevoel word. Elektronies-beheerbare lineêre aandrywers en 'n pasgemaakte krag-oordraerstelsel vir die meet van ortodontiese kragte word gebruik om 'n prototipe te vervaardig. Elektroniese stroombane word ontwikkel om die apparaat te koppel aan 'n USB poort sodat dit beheer kan word d.m.v. 'n gra ese gebruikerskoppelvlak. Eksperimente poog om die apparaat funksioneel te evalueer volgens die voorgestelde hipotese. Ter afsluiting: die toepaslikheid van die verwerfde resultate in die ortodontiese vakgebied word beklemtoon en aanbevelings word gemaak vir toekomstige/verdere ontwikkelings m.b.t. 'n elektromeganiese ortodontiese apparaat.
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Berni, Paulo Roberto de Araujo. "Food structure design to modulate bioaccessibility of carotenoids from brazilian native fruits after screening of eleven non-conventional tropical fruits." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/11/11141/tde-14032019-114205/.
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Brazil is the country with the greatest biodiversity on the planet and a major producer of food. Tropical fruits, especially natives from Brazil, may contain considerable amounts of carotenoids that have antioxidant, anti-inflammatory, provitamin A and anticancer actions, such as β-carotene and lycopene. The food structure design concept aims to manipulate the food matrix for specific purposes, e.g. the preservation and manipulation of carotenoid bioaccessibility. The aim of this thesis was to explore tropical fruits, native and exotic from Brazil in the development of delivery systems for carotenoids. A screening step was carried out with 11 fruits, among which 2 were selected, the pitanga (Eugenia uniflora) and buriti (Mauritia flexuosa) fruits that were used for the production of microemulsions. At the screening were evaluated the proximate composition, fiber contents, carotenoid profiles and bioacessibilities. The nutritional value demonstrated that these fruits have high potential as raw-materials for healthy products due to their high fiber, minerals and carotenoid contents in addition to low energy value. Analysis by HPLC-DAD allowed the identification of 14 carotenoids in the 11 fruits studied for the screening. Results demonstrated the superiority of the bioaccessibility of xanthophylls (ranging 10 % - 52 %) in relation to carotenes, and the low bioaccessibility of lycopene from pitanga (1.1 %) and average bioaccessibility of β-carotene from buriti (26 %). Pitanga and buriti had their carotenoid profiles analyzed and monitored throughout an in vitro simulation of the digestion coupled with caco-2 cell cultures. Although xanthophylls are more bioaccessible, the intestinal ephitelium absorb preferentially the provitamin A carotenoids, such β-carotene and β-criptoxanthin. In order to produce these microemulsions, high-speed homogenization (HSH) and ultrasound (US) were studied in combination with the use of surfactants (Whey Protein Isolate and Tween 80), and addition of corn oil as carotenoid carrier. The experiments have shown that the interaction of US and HSH is capable to break cell walls and release carotenoids with higher efficiency. Optical and fluorescence microscopy, as well as carotenoid analysis demonstrated that it was possible to manipulate the food matrix structure releasing the carotenoids from the plant cells and encapsulating them inside the oil droplets, what increased their retention after processing. The microemulsion were affected by time of processing and by surfactant related to their rheology, final structure, stability of emulsion and carotenoid stability to processing. Finally, a dynamic gastrointestinal system was used to compare the behavior of carotenoids from whole fruit pulps and selected microemulsions (2% Tween 80, 5% corn oil, processed by HSH-US 4 min -4 min). The results demonstrated that it was possible to increase the stability to digestion and bioaccessibility of total carotenoids, lycopene and β-carotene from the microemulsions.O Brasil é o país detentor da maior biodiversidade do planeta e um grande produtor de alimentos. Frutas tropicais, em especial as nativas brasileiras, podem conter quantidades consideráveis de carotenoides que possuem ação antioxidante, anti-inflamatória, provitamina A e anticâncer, como β-caroteno e licopeno. O desenho estrutural dos alimentos (food structure design), visa manipular a matriz alimentar com fins específicos, por exemplo, a preservação e manipulação da bioacessibilidade de carotenoides. Na presente tese buscou-se explorar frutas brasileiras não-convencionais no desenvolvimento de sistemas de entrega de carotenoides. Foi realizada uma etapa de triagem com 11 frutas, dentre as quais, 2 foram selecionadas, a pitanga (Eugenia uniflora) e o buriti (Mauritia flexuosa), e utilizadas na produção de microemulsões. Nesta triagem foram avaliadas a composição centesimal, o teor de fibras, o perfil de carotenoides e a bioacessibilidade destes carotenoides. O valor nutricional das frutas demonstrou seu potencial para utilização em produtos saudáveis, devido a seus teores eleveados de fibras, minerais e carotenoides além do baixo teor calórico. A análise por HPLC-DAD permitiu identificar até 14 carotenoides nas amostras das 11 frutas estudadas na triagem. O estudo da bioacessibilidade dos carotenoides das 11 frutas demonstrou principalmente a superioridade da bioacessibilidade de xantofilas (variando de 10 a 52 %) em relação aos carotenos, e portanto a baixa bioacessibilidade de licopeno da pitanga (1,1%) e média bioacessibilidade de β-caroteno do buriti (26%). Pitanga e buriti tiveram o perfil de carotenoides detalhadamente acompanhados através da simulação in vitro da digestão associada à absorção intestinal por culturas de células Caco-2. Neste estudo, observou-se que embora as xantofillas sejam mais bioacessíveis, o tecido epitelial do intestino absorve preferencialmente carotenoides provitaminicos A, como o β-caroteno e a β-criptoxantina. Para produzir as microemulsões foram estudados processamentos (homogeneização de alta-velocidade - HSH e ultrassom - US) em combinação com uso de surfactantes (Whey Protein Isolate e Tween 80) e adição de óleo de milho como carreador dos carotenoides. Os experimentos mostraram que a interação entre US e HSH é capaz de romper as paredes celulares e liberarem os carotenoides com maior eficiência. Ficou demonstrado através de microscopia ótica e de fluorescência, tanto quanto pela análise de carotenoides, que foi possível manipular estruturalmente a matriz alimentar liberando os carotenoides de dentro das células vegetais e encapsulando-os dentro das gotículas de óleo, além de aumentar sua retenção após o processamento. As microemulsões obtidas sofreram efeito do tempo de processamento e do surfactante em relação à reologia, estrutura final da matriz, estabilidade ao armazenamento e estabilidade dos carotenoides ao processo. Por fim, foi utilizado um sistema dinâmico de simulação da digestão gastrointestinal para comparar o comportamento dos carotenoides oriundos das polpas integrais das frutas e das microemulsões selecionadas (Tween 80 a 2%, óleo de milho a 5% e processado por HSH-US 4 min-4 min). Os resultados demonstraram que foi possível aumentar a estabilidade à digestão e a bioacessibilidade dos carotenoides totais, do licopeno e do β-caroteno.
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Hosseini, Rahimeh, and Anita Nolsjö. "The effect of reinforcement configuration on crack widths in concrete deep beams." Thesis, KTH, Betongbyggnad, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-208709.
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Reinforced concrete deep beams are known for applications in tall buildings, foundations and offshore structures. Deep beams are structural elements with length and height within the same magnitude and have significantly smaller thickness compared to a conventional concrete beam. Deep beams in bending have non-linear strain distribution compared to conventional beams where Bernoulli’s hypothesis is valid. Crack formation is a common problem in reinforced concrete structures, which reduce the durability of the structure. Once the concrete cracks the tension reinforcement carry the tensile forces instead of the concrete. Therefore, the design of tension reinforcement is important since the serviceability should be retained even after the structure cracks. The crack widths can be limited by using proper reinforcement and one alternative is to combine tensile reinforcement with crack reinforcement. The function of the reinforcement is to distribute the cracks over the cross section which leads to that many smaller cracks occur instead of fewer, wider cracks. Small cracks are seen as less of a problem compared to large cracks since larger cracks reduce the durability significantly. For deep beams, there is at the present no well-substantiated analysis model for how crack widths shall be calculated when having reinforcement in multiple layers with different diameters. The use of crack reinforcement in the outer bottom layer has by tradition been considered as a cost efficient way to achieve small crack widths. In this work the crack width in deep beams have been analysed using the finite element program Atena 2D. The numerical results have been verified by analytical calculations based on Eurocode 2. The aim is to achieve reduced crack widths by analysing the combination of crack- and tensile reinforcement compared to the case with tensile reinforcement only. Tensile reinforcement has a larger diameter, for example ø25 mm, and crack reinforcement has smaller diameters, often between ø10 and ø16 mm. The result from the calculations with Atena showed that there was an improvement regarding the reduction of crack widths when using crack reinforcement in combination with tensile reinforcement compared to using tensile reinforcement only. However, this improvement decreased by using reinforcement in multiple layers since a tensile reinforcement bar 1ø25 mm needed to be replaced by approximately six crack reinforcement bars 6ø10 mm in order to achieve the same total reinforcement area. The main disadvantage was that more space was required to place all reinforcement bars in the cross section, which reduced the lever arm. The reduction of the lever arm resulted in a reduced capacity for the reinforcement and the cracks might unintentionally become wider than expected. Furthermore, significant reduction of both crack widths and reinforcement stresses were obtained when the total area for a case with 7ø25 mm was increased to 9ø25 mm. The increased total area of only tensile reinforcement ø25 mm reduced the crack width more compared to using a combination of crack- and tensile reinforcement, which could simplify the construction work at building sites and minimize time consumption.Armerade höga betongbalkar är kända för tillämpningar i höga byggnader, grundsulor och offshore konstruktioner. Höga balkar är konstruktionselement med längd och höjd i samma storleksordning och har betydligt mindre tjocklek jämfört med en konventionell betongbalk. Höga balkar i böjning har en icke-linjär töjningsfördelning jämfört med konventionella balkar där Bernoullis hypotes gäller. Sprickbildning är ett vanligt problem i armerade betongkonstruktioner, vilket minskar beständigheten hos konstruktionen. När betongbalken spricker kommer armeringen att ta upp dragkraften istället för betongen därför är utformningen av böjarmering viktig eftersom bruksgränstillståndet bör behållas även efter att konstruktionen spricker. Sprickvidderna kan begränsas genom att använda korrekt armering och ett alternativ är att kombinera kraftarmering med sprickarmering. Armeringens funktion är att sprida ut sprickorna över tvärsnittet vilket leder till att många små sprickor uppkommer i stället för färre, bredare sprickor. Små sprickor ses som ett mindre problem jämfört med stora sprickor eftersom större sprickor minskar beständigheten avsevärt. För höga balkar finns det för närvarande ingen välunderbyggd analysmodell för hur sprickvidder ska beräknas när de har armering i flera lager och med olika diametrar. Användningen av sprickarmering har traditionellt ansetts vara ett kostnadseffektivt sätt att uppnå små sprickvidder. I detta arbete har sprickvidden i höga balkar analyserats med hjälp av finita elementprogrammet Atena 2D. De numeriska resultaten har verifierats med analytiska beräkningar baserade på Eurokod 2. Syftet är att uppnå reducerade sprickvidder genom att analysera kombinationen av sprick- och kraftarmering jämfört med fallet med endast kraftarmering. Kraftarmeringen har en större diameter, till exempel ø25 mm och sprickarmering har mindre diametrar, ofta mellan ø10 och ø16 mm. Resultaten från beräkningarna i Atena visade att sprickvidderna minskade vid användning av sprickarmering i kombination med kraftarmering jämfört med användning av endast kraftarmering. Denna förbättring minskade emellertid i och med användning av armering i flera lager. En kraftarmeringsstång 1ø25 mm behöver ersättas med ungefär sex sprickarmeringsstänger, 6ø10 mm, för att uppnå samma totala armeringsarea. Den största nackdelen var att det krävdes mer utrymme för att placera alla sprickarmeringsstänger i tvärsnittet, vilket minskade hävarmen. Minskningen av hävarmen medförde en reducerad kapacitet i armeringen och sprickorna blev bredare än förväntat. Vidare erhölls signifikant reduktion av både sprickvidder och armeringsspänningar när den totala arean för ett fall med 7ø25 mm ökades till 9ø25 mm. Den ökade totalarean av endast kraftarmeringsstänger ø25 mm minskade sprickvidden mer jämfört med att använda en kombination av sprick- och kraftarmering vilket skulle kunna förenkla byggarbetet på byggarbetsplatser och minimera tidsförbrukningen.
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Larabi, Islam Amine. "Nouveaux produits de synthèse : analyse, consommation et métabolisme ; Applications cliniques et médicolégales Rapid and simultaneous screening of new psychoactive substances and conventional drugs of abuse. A comparative study of Biochip Array Technology versus LC-MS/MS in whole blood and urine Development of a sensitive untargeted liquid chromatography– high resolution mass spectrometry screening devoted to hair analysis through a shared MS2 spectra database: A step toward early detection of new psychoactive substances Validation of an UPLC-MS/MS method for the determination of sixteen synthetic cannabinoids in human hair. Application to document chronic use of JWH-122 following a non-fatal overdose Development and validation of liquid chromatography-tandem mass spectrometry targeted screening of 16 fentanyl analogs and U-47700 in hair: Application to 137 authentic samples Prevalence and Surveillance of Synthetic Cathinones Use by Hair Analysis: An Update Review Prevalence of New Psychoactive Substances(NPS) and conventional drugs of abuse (DOA) in high risk populations from Paris(France) and its suburbs A cross sectional study by hair testing(2012–2017) Evaluation of drug abuse by hair analysis and self-reported use among MSM under PrEP: Results from a sub-study of the ANRS-IPERGAY trial. Hair testing for 3‑fluorofentanyl, furanylfentanyl, methoxyacetylfentanyl, carfentanil, acetylfentanyl and fentanyl by LC–MS/MS after unintentional overdose Drug‐facilitated sexual assault (DFSA) involving 4‐methylethcathinone (4‐MEC),3,4‐Methylenedioxypyrovalerone (MDPV), and doxylamine highlighted by hair analysis Metabolic Profiling of Deschloro-N-ethyl-ketamine (O-PCE) and identification of new target metabolites in urine and hair using human liver microsomes and high-resolution accurate mass spectrometry." Thesis, université Paris-Saclay, 2020. http://www.theses.fr/2020UPASL029.
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L’objectif de ce travail a été de développer deux approches analytiques dédiées à l’analyse toxicologique des nouveaux produits de synthèse (NPS) dans différentes matrices biologiques (sang, urine et cheveux). La première est basée sur le criblage non ciblé par chimiluminescence sur biopuces et chromatographie liquide couplée à la spectrométrie de masse haute résolution (LC-HRMS) et la deuxième correspond à un criblage ciblé par spectrométrie de masse en tandem (LC-MS/MS). Ces deux approches ont ensuite été appliquées dans des études observationnelles pour évaluer la consommation de NPS dans des populations à risques de surdosage, de pharmacodépendance ou de soumission chimique dans un contexte clinique ou médico-judiciaire.La dernière partie a été consacrée au développement d’un nouvel outil analytique de traitement des données issues de la LC-HRMS qui a permis d’étudier le métabolisme de 9 NPS in vitro sur des cultures de microsomes du foie humain (HLM) et in vivo sur des échantillons biologiques d’usagers de ces drogues. Cette dernière approche a permis la création d’une bibliothèque de spectres de haute résolution composée de 228 métabolites dont certains ont été proposés comme marqueurs pertinents d’exposition aux NPS dont ils sont issus.Ce travail a été concrétisé par la rédaction de 10 publications scientifiques et a permis d’initier plusieurs collaborations pluridisciplinairesThe aim of the present work was to develop two analytical approaches dedicated to the analysis of new psychoactive substances in different biological matrices (blood, urine and hair). The first approach is based on untargeted screening by both biochip array technology chemiluminescence assay and liquid chromatography coupled to high resolution mass spectrometry (LC-HRMS) and the second corresponds to a targeted screening by liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS). These two approaches were then applied in observational studies to assess the consumption of NPS in high risk populations (overdose, drug abuse, drug facilitated crimes) in clinical and forensic settings. The last part of the work was devoted to the development of a new analytical tool for LC-HRMS data processing which made it possible to study the metabolism of 9 NPS In vitro on human liver microsomes (HLM) and In vivo in biological samples from drug users. This approach has enabled the creation of HRMS spectral library containing 228 metabolites, some of which have been proposed as relevant markers of NPS exposure.This work has resulted on 10 scientific publications and allowed to initiate many multidisciplinary collaborations
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Neto, Rui Jorge de Lemos. "Development of non-conventional casting processes." Doctoral thesis, 2015. https://repositorio-aberto.up.pt/handle/10216/104098.
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Neto, Rui Jorge de Lemos. "Development of non-conventional casting processes." Tese, 2015. https://repositorio-aberto.up.pt/handle/10216/104098.
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Alancherry, Surjith. "Development of carbon nanostructures from non-conventional resources." Thesis, 2018. https://researchonline.jcu.edu.au/59139/1/JCU_59139_alancherry_2018_thesis.pdf.
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Carbon nanostructures (CNSs) perpetuate the scientific interest over decades due to their remarkable properties and emerging technological applications. The development of sustainable technologies for the synthesis of CNSs from natural resources grabbed immense research attention aiming to implement these high-end materials in wide range of nano electronic devices through safe and environmentally friendly routes. Even though a number of top down and bottom up approaches have been developed for the production of CNSs, most of them either aided by catalysts or involved solvent assisted multi-step process that considerably increase the cost of production and hinders the realization of low cost CNSs based commercial devices. In addition, vast majority of these techniques use high pure petroleum derived hydrocarbon gas precursors that are non-renewable and expensive. Hence, it is imperative to develop scalable techniques that can derive high quality CNSs directly on arbitrary substrates from naturally derived carbon feed stocks. This work aims to develop an environmentally benign plasma enhanced chemical vapor deposition technique for fabricating CNSs from Citrus sinensis essential oil, a bio renewable precursor, and explored the potential of these nanostructures for gas sensing application.
C. sinensis essential oil, obtained through cold extraction of orange peels is a rich source of non-synthetic hydrocarbon compounds principally limonene. Inherently volatile in nature, C. sinensis essential oil can serve as an ideal candidate material compatible to plasma enhanced chemical vapor deposition. This thesis investigated the fabrication of vertically-oriented graphene nanostructures from C.sinensis essential oil through radio frequency plasma enhanced chemical vapor deposition process, the fundamental properties, extend to which the process parameters influenced the structure and morphological features, and the suitability of the developed vertical graphene arrays for gas sensing applications. Special attention is paid to probe deep into the morphological evolution with the help of a set of advanced analytical characterization methods and multi-parameter model simulations.
In the first phase, C.sinensis vapors were subjected to low RF power glow discharge that resulted in the formation of plasma polymer thin films, and the material properties were studied as a function of input RF energy. The fundamental properties of plasma polymer thin films fabricated at different RF power level (10−75 W) were characterized with variable angle spectroscopic ellipsometry, UV-visible spectroscopy, Fourier transform infrared spectroscopy X-ray photoelectron spectroscopy and atomic force microscopy. Optical characterization showed that independent of deposition power films exhibited good transparency (~90 %) in the visible region and a refractive index of 1.55 at 500nm. The optical band gap measured around 3.60 eV and falls within the insulating region. The atomic force microscopic (AFM) images revealed that the surface is pinhole-free and smooth at nanoscale, with average surface roughness dependent on the deposition power. Film hardness increased from 0.50 GPa to 0.78 GPa as applied power increased from 10 to 75 W.
In the second phase, experiments were modified by redesigning the experimental set up in order to eliminate hydrogen from the deposits leaving only crystalline carbon. The RF power deliberately kept high, substrate temperature was raised and hydrogen gas fed into the reactor in controlled manner. A sequence of experiments were carried out by systematically changing the process parameters such as in put RF power (300-500W), hydrogen flow rate (10-50 sccm) and deposition duration (2-8 min) and analysed the structural and morphological evolution of the resulted vertical graphene nanostructure.
The structure-property correlation of vertical graphene arrays with the plasma process parameters was performed. The Raman spectra ascertained the formation of less defected multilayered graphene nanostructures and scanning electron microscopic images provided the primary evidences of morphological evolution. The potential of the novel analytical techniques such as Hough transformations, fractal dimension distributions and Minkowski connectivity for the analysis of graphene array morphology was then successfully demonstrated. Worth noting that, these advanced techniques displayed significant changes and revealed the complex morphological transformation of C. sinensis derived vertical graphene subjected to change in process conditions. Precisely, vertical graphene nanowalls obtained at 300 and 500W presented a narrow height distribution profile but much wider array formed at 400 W. Fourier and Hough transformation spectra showed a prominent change with an increase in power, thus highlighted change in the morphology with the density of nanoflakes. Similarly, 2D FFT transform spectra of vertical graphene samples also presented notable changes with increasing hydrogen flux. The most narrow height distributions, well-shaped Hough transformation spectra and distribution of fractal dimensions obtained for structures formed at 20 and 50 sccm of hydrogen flow rate. In addition to this, the principal characteristics of thus fabricated vertical graphene such as flake length (Lvg) and flake half width (Wvg) are theoretically modelled by an ad hoc model based on a large number of interaction elemental processes and correlated with the experimental results. The combination of the experimental and simulation results ensured important insights and deeper understanding of the processes that govern formation of the vertical graphene morphology.Vertical graphene nanostructures having superior structural and morphological properties were successfully fabricated at an input RF energy of 500W, hydrogen flow rate of 30 sccm and deposition duration of 6 minutes.
The third phase presented an in-depth study of the properties of C.sinensis oil derived graphene over a set of conducting (copper and nickel) and insulating substrates (silicon and quartz). The SEM images of thus fabricated graphene patterns showed the unique feature of vertically interconnected and non-agglomerated carbon nanowall structures having maze-like and petal-like networks. Moreover, the normalized height distribution function and 2-D FFT spectra analysis ascertained that vertical graphene formed on silicon substrates displayed the most uniform distribution. X-ray photoelectron spectroscopy spotted only the presence of carbon and the transmission electron microscopic studies revealed the formation of unique onion-like closed loops. The 3-D nanoporous structure of C.sinensis oil derived graphene showed high hydrophobicity and measured a water contact angle of 129°. The surface energy studies were performed using Neumann model, Owens-Wendt-Kaelble approach and van Oss- Chaudhury-Good relation and estimated within the range 35‒41 mJ/m².
Finally, plasma reformed vertical graphene from C. sinensis was integrated into a sensor device prototype to evaluate the performance in gas sensing. The chemiresistive type sensor exhibited sensing activity towards acetone. In summary, this thesis has identified a viable renewable resource and successfully developed a process that transform them into vertical graphene nanostructures. Furthermore, the fabricated graphene was integrated to real world devices and evaluated the performance. The outcomes of this investigation add knowledge base to the state-of-the-art of green chemistry approach for the synthesis of vertical graphene carbon nanostructures.
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"Design and Development of Flexible Sensors Using Non-Conventional Methods." Master's thesis, 2018. http://hdl.handle.net/2286/R.I.49206.
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abstract: In this work, different methods for fabrication of flexible sensors and sensor characterization are studied. Using materials and equipment that is unconventional, it is shown that different processes can be used to create sensors that behave like commercially available sensors. The reason unconventional methods are used is to cut down on cost to produce the sensors as well as enabling the manufacture of custom sensors in different sizes and different configurations. Currently commercially available sensors are expensive and are usually designed for very specific applications. By creating these same types of sensors using new methods and materials, these new sensors will show that flexible sensor creation for many uses at a fraction of the cost is achievable.Dissertation/Thesis
Masters Thesis Engineering 2018
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Lopes, Rui Manuel Jesus 1979. "Development of non-conventional formulations of dinitroanilines for the treatment of leishmaniasis." Doctoral thesis, 2013. http://hdl.handle.net/10451/9956.
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Tese de doutoramento, Farmácia (Tecnologia Farmacêutica), Universidade de Lisboa, Faculdade de Farmácia, 2013Modern chemotherapy in general, and against microbial infections in particular, aims at targeting drugs to diseased sites while reducing side-effects. This strategy was applied to fight leishmaniasis, a parasitic disease with no treatment combining high activity with low toxicity at affordable costs. Dinitroanilines are a class of molecules with proved in vitro antileishmanial activity but compromised use in clinic, by unfavorable proprieties. To overcome these drawbacks and potentiate their therapeutic activity, two complementary strategies were followed. One concerns the development of lipid-based nanoformulations of one dinitroaniline, Oryzalin, via incorporation in liposomes and solid lipid nanoparticles (LNP), as means to direct the drug to the sites of infection. Another strategy concerns the synthesis of new dinitroaniline analogues, the selection of the most active, production of respective nanoformulations and their in vivo evaluation. A systematic comparison of both native and chemically modified dinitroanilines and respective nanoformulations was done.Oryzalin incorporated in liposomes and LNP presented reduced cytotoxicity and haemolysis, when compared with free-oryzalin, while retaining the in vitro activity. Its performance in vivo was strongly improved by incorporation in liposomes, as evidenced by an increased accumulation in the main organs affected by Leishmania infection. The therapeutic activity assessed in a visceral leishmaniasis model demonstrated the superiority of both Oryzalin nanoformulations on the reduction of parasite burden as compared to the free molecule. Chemical modification allowed to identify active dinitroaniline analogues in vitro that were efficiently incorporated in liposomes and LNP and tested in vivo. The nanoformulations of one analogue in particular (TFLA6) strongly reduced the in vivo parasite burden (80-96%). Moreover, nanoformulations are stable throughout freeze-drying and moistheath sterilisation without significant variations on physicochemical properties. This work demonstrated the improvement of native and chemically modified dinitroanilines anti-leishmanial activity through their association to liposomes and LNP. This strategy allowed the achievement of dinitroaniline nanoformulations that are potential candidates as therapeutic agents against visceral leishmaniasis.
A quimioterapia moderna em geral e contra infecções microbianas em particular, tem como objectivo direccionar fármacos para o local da infecção, reduzindo os efeitos secundários. Esta estratégia foi aplicada no tratamento da leishmaniose, doença parasitária sem tratamento combinando elevada actividade, baixa toxicidade e custos acessíveis. As dinitroanilinas são moléculas com actividade leishmanicida in vitro mas com aplicação clinica comprometida por propriedades desfavoráveis. Para superar estes problemas e potenciar a sua actividade terapêutica, foram seguidas duas estratégias complementares. O desenvolvimento de nanoformulações de base lipídica de uma dinitroanilina, Orizalina, através da incorporação em lipossomas e nanopartículas lipídicas (LNP), de modo a direccioná-la para os locais de infecção. A outra estratérgia envolve a síntese de novos análogos de dinitroanilina, a selecção dos mais activos, a produção das respectivas nanoformulações e avaliação in vivo. Foi efectuada uma comparação sistemática entre dinitroanilinas comerciais e modificadas quimicamente e respectivas nanoformulações.A Orizalina incorporada em lipossomas e LNP apresentou redução da citotoxicidade e hemólise, comparativamente ao fármaco na forma livre, e retendo a actividade in vitro. O desempenho in vivo foi significativamente melhorado após incorporação em lipossomas, evidenciado pelo aumento da acumulação nos órgãos alvo. A actividade terapêutica avaliada num modelo de leishmaniose visceral demonstrou a superioridade das duas nanoformulações de orizalina na redução da carga parasitária, em comparação com orizalina na forma livre. A modificação química permitiu identificar análogos activos in vitro que foram eficazmente incorporados em lipossomas e LNP e avaliados in vivo. As nanoformulações de um análogo em particular (TFLA6) reduziram significativamente a carga parasitária in vivo (80-96 %). As nanoformulações são estáveis durante liofilização e esterilização térmica sem variações significativas nas propriedades físico-químicas. Este trabalho demostrou a melhoria da actividade leishmanicida de dinitroanilinas comerciais e quimicamente modificadas através da associação a lipossomas e LNP. Esta estratégia permitiu a obtenção de algumas nanoformulações de dinitroanilinas que são potenciais candidatos a agentes terapêuticos no tratamento de leishmaniose visceral.
Fundação Para a Ciência e a Tecnologia (FCT, SFRH/BD/44218/2008, projeto PTDC/CVT/098290/2008); FEDER
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Khan, Muhammad Salman. "Development of Protection Scheme for Non-Conventional Instrument Transformer (NCITs) Based on IEC 61850-9-2." Thesis, 2015. https://vuir.vu.edu.au/31829/.
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Substations are a fundamental part in electrical energy transmission and distribution. The role of a substation is to transfer and transform electrical energy by stepping up or down the voltage. To do this, high voltage switching equipment and power transformers are used, in addition to instrument transformers that supply the status of the primary system to the secondary equipment. Substation Automation Systems are then used to control, protect and monitor the substations [1]. The IEC 61850 standard developed digital substation with most advanced techniques. The IEC 61850 standard define in its sub-clauses IEC 600448 and IEC 61850-9-2 about digital interface, digital communication and Sampled Values transmission over an Ethernet link called Process Bus. This thesis is mainly based on the development of the non Conventional Instrument Transformers (NCIT), analogue to digital data converter and power system protection.
Books on the topic "Non-conventional development"
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Negrete, Plinio. Research and development in non conventional energies: Bases of a program. Caracas: Fundación para el Desarrollo Social de la Región Capital, 1986.
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Tomar, S. S. Energy agriculture and environment: With special reference to non-conventional energy sources in development of rural areas. New Delhi, India: Mittal Publications, 1995.
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Ghavami, Khosrow. Non-Conventional Materials and Technologies for Sustainable Development. Trans Tech Publications, Limited, 2015.
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Ghavami, Khosrow. Non-Conventional Materials and Technologies for Sustainable Development. Trans Tech Publications, Limited, 2016.
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United Nations. Dept. of Technical Cooperation for Development., ed. The Use of non-conventional water resources in developing countries. New York: United Nations, 1985.
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United Nations. Economic and Social Commission for Western Asia., ed. Development of freshwater resources in the rural areas of the ESCWA region using non-conventional techniques. New York: United Nations, 2001.
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Hall, Anthony. South-South Cooperation for Social Development. Edited by Edmund Amann, Carlos R. Azzoni, and Werner Baer. Oxford University Press, 2018. http://dx.doi.org/10.1093/oxfordhb/9780190499983.013.27.
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Under President Lula (2003–2010), Brazil’s foreign aid program expanded significantly into the area of South-South cooperation. This included the “soft power” fields of social protection, food security, agricultural research, and humanitarian assistance, among others, with a particular emphasis on supporting Sub-Saharan Africa, notably but not exclusively Portuguese-speaking countries. Much of this aid was provided with the support of technical assistance from UN agencies such as UNDP and FAO and bilateral aid bodies, via trilateral agreements, under the coordination of Brazil’s International Cooperation Agency (ABC). South-South collaboration is considered to be morally superior to conventional aid arrangements, being supposedly demand-driven and “non-exploitative,” thus empowering recipients in the process. Brazilian policymakers sought to transfer national anti-poverty initiatives to Africa. This was based initially on the Bolsa Família conditional cash transfer (CCT) program, but other nutritional food security initiatives followed, such as boosting small farmer production as well as supporting agribusiness.
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Leal, Rui Manuel, and Ivan Galvão, eds. Recent Developments in Non-conventional Welding of Materials. MDPI, 2022. http://dx.doi.org/10.3390/books978-3-0365-3874-7.
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Keyuan, Zou. 28 The South China Sea. Oxford University Press, 2015. http://dx.doi.org/10.1093/law/9780198715481.003.0028.
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This chapter assesses the legal regime of the South China Sea. It first discusses legal issues concerning the South China Sea, including sovereignty and territorial disputes, maritime disputes, the controversy over China's ‘U-shaped’ line, and the relation between conventional rights deriving from the UN Nations Convention on the Law of the Sea (LOSC) and historic rights embodied in international customary law. It then considers the applicable international law in the South China Sea including the LOSC and regional arrangements such as the 2002 Declaration on the Conduct of Parties in the South China Sea. The final section considers the latest developments in the South China Sea including the Philippines v China case. It discusses the possibility of cooperation in the region between or amongst claimants as well as between ASEAN and China through feasible means, such as joint development, joint management of fishery resources, common responsibilities for the protection of the marine environment and cooperation in non-traditional security issues.
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Kamrava, Mehran. Troubled Waters. Cornell University Press, 2018. http://dx.doi.org/10.7591/cornell/9781501720352.001.0001.
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This book examines the causes and consequences of each of those dynamics, both individually and collectively, that have made this small waterway and its surrounding areas one of the most volatile and tension-filled regions in the world. This pervasive insecurity, the book argues, is largely a product of four interrelated developments. The examination of these four central developments forms the central basis around which the book’s arguments are organized. Briefly, they include preoccupation with “conventional” security threats at the expense of pervasive, though largely intangible, non-conventional “critical security” issues; the flawed nature of the prevailing security architecture, which, ironically, perpetuates regional insecurity; the deliberate actions and policies of the regional and extra-regional actors involved in the Persian Gulf; and, the self-reinforcing nature of the region’s security dilemma.
Book chapters on the topic "Non-conventional development"
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Omran, El-Sayed Ewis. "Cloud-Based Non-conventional Land and Water Resources for Sustainable Development in Sinai Peninsula, Egypt." In The Handbook of Environmental Chemistry, 339–74. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/698_2017_63.
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Nzioka, Simon Muteti, and Abdul Ebrahim Haro. "Contributing to Peace and Sustainable Solutions in a Non-conventional Displacement Situation: A Case of Kenya-Ethiopia Border in East and Horn of Africa." In Peace Studies for Sustainable Development in Africa, 393–404. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-92474-4_32.
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Bunderson, W. Trent, Christian L. Thierfelder, Zwide D. Jere, and R. G. K. Museka. "Assessing the application and practice of conservation agriculture in Malawi." In Conservation agriculture in Africa: climate smart agricultural development, 151–75. Wallingford: CABI, 2022. http://dx.doi.org/10.1079/9781789245745.0008.
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Abstract The Conservation Agriculture (CA) system promoted by Total LandCare (TLC) and the International Maize and Wheat Improvement Center (CIMMYT) is based on 14 years of experience grounded on the principles of minimum soil disturbance, good soil cover and crop associations. The platform to promote CA in Malawi was to build a strong base of knowledge about best practices through an innovative non-linear research-extension approach. Long-term on-farm trials were conducted in multiple sites across Malawi to compare yields and labour inputs of CA with conventional ridge tillage on the same footing. Results showed the superiority of CA in terms of maize and legume yields with significant savings in labour and resilience to climate change. The results provided the basis to upscale CA although adoption was lower than expected. Key challenges included: (i) lack of exposure and training; (ii) conflicting extension messages; (iii) misconceptions about inputs and tools for CA; (iv) resistance to change unless CA is clearly seen to be a better practice; (v) fears about controlling weeds, pests and diseases under CA; and (vi) perceptions that increased termites and earthworms are harmful to soils and crops.
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Acevedo, Elkin A. Caro, and Alvaro Jaramillo Duque. "Guidelines to Define a Regulatory Proposal in the Transition and Inclusion of Non-conventional Renewable Energies in Colombia and Its Role in the Development of Smart Cities." In Proceedings of the 6th Brazilian Technology Symposium (BTSym’20), 227–37. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-75680-2_27.
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Schweitzer, Ryan. "The Role of Teahouses in Central Asia: A Case Study of the Ferghana Valley." In Securitization and Democracy in Eurasia, 229–41. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-031-16659-4_15.
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AbstractTeahouses (chaikhana) in the Ferghana Valley of Kyrgyzstan, Tajikistan, and Uzbekistan provide social benefits and help facilitate the development of civil society. Civil society formation in Central Asia does not operate in the same ways as conventional accounts of civil societies claim due to government control, interference, and repression. As such, civil society forms in the peripheries of society, outside the reach of government control. Through interviews and non-participant observations conducted in 2021 throughout the Ferghana Valley, I aim to understand the specific ways in which chaikhana operate in the social sphere, allowing civil society to function outside the government’s control and, in turn, laying the foundations for civil society development. This research determines that, although governments try to limit the ability of social networks and freedom of expression, these connections occur through meetings in social spaces, such as in teahouses. This research will fill the gaps in understanding why chaikhana are still allowed to operate, even though they are prime locations for the development of civil society. In summary, this research seeks to understand the chaikhana’s role as an integral component of Central Asian civil society and the ways in which it continues to operate under adverse governmental and societal conditions.
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Mandelis, A. "Photothermal Detection at Surfaces and Interfaces: Developments in Non-Conventional Diagnostics." In Photoacoustic and Photothermal Phenomena III, 657–63. Berlin, Heidelberg: Springer Berlin Heidelberg, 1992. http://dx.doi.org/10.1007/978-3-540-47269-8_168.
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Filipović, Nenad, Nina Tomić, Maja Kuzmanović, and Magdalena M. Stevanović. "Nanoparticles. Potential for Use to Prevent Infections." In Urinary Stents, 325–39. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-031-04484-7_26.
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AbstractOne of the major issues related to medical devices and especially urinary stents are infections caused by different strains of bacteria and fungi, mainly in light of the recent rise in microbial resistance to existing antibiotics. Lately, it has been shown that nanomaterials could be superior alternatives to conventional antibiotics. Generally, nanoparticles are used for many applications in the biomedical field primarily due to the ability to adjust and control their physicochemical properties as well as their great reactivity due to the large surface-to-volume ratio. This has led to the formation of a new research field called nanomedicine which can be defined as the use of nanotechnology and nanomaterials in diagnostics, imaging, observing, prevention, control, and treatment of diseases. For example, coverings or coatings based on nanomaterials are now seen as a promising strategy for preventing or treating biofilms formation on healthcare kits, implants, and medical devices. Toxicity, inappropriate delivery, or degradation of conventionally used drugs for the treatment of infections may be avoided by using nanoparticles without or with encapsulated/immobilized active substances. Most of the materials which are used and examined for the preparation of the nanoparticles with encapsulated/immobilized active substances or smart reactive nanomaterials with antimicrobial effects are polymers, naturally derived antimicrobials, metal-based and non-metallic materials. This chapter provides an overview of the current state and future perspectives of the nanoparticle-based systems based on these materials for prevention, control, or elimination of biofilm-related infections on urinary stents. It also addresses manufacturing conditions indicating the huge potential for the improvement of existing and development of new promising stent solutions.
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de Bruin, Esmée. "Export Control Regimes—Present-Day Challenges and Opportunities." In NL ARMS, 31–53. The Hague: T.M.C. Asser Press, 2021. http://dx.doi.org/10.1007/978-94-6265-471-6_3.
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AbstractThe system of export control regimes is an important instrument to prevent the proliferation of both weapons of mass destruction and conventional weapons. However, this system faces several structural and recent challenges. The regimes are informal, and consequently, their measures are non-binding upon states. Second, the regimes consist of a selective group of countries, excluding some dominant arms exporters. New technology is rapidly changing the military field, and it is difficult for the export control regimes to keep up with these developments. Further, most of the regimes were designed when states were the most important international actors while currently legitimate and illegitimate non-state actors play an ever-increasing role for export controls. In addition, it is unclear how the regimes will advance with the multipolar world order of the twenty-first century. All new developments could lead to the proliferation of weapons, making efforts to prevent proliferation more relevant than ever. There are several opportunities to reform and strengthen the export control regimes. Cooperation could help the regimes to remain relevant. The sharing of good practices can help the regimes to find the least disruptive and effective non-proliferation measures. Setting up a paradigm-based regime instead of a weapon-based regime may be more suitable for the future. In addition, a revision of the decision-making process would help the regimes to respond swiftly to developments in the field.
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Peças, Paulo, Pedro Dias Pereira, Inês Inês Ribeiro, and Elsa Henriques. "Non-Conventional Technologies Selection." In Non-Conventional Machining in Modern Manufacturing Systems, 1–32. IGI Global, 2019. http://dx.doi.org/10.4018/978-1-5225-6161-3.ch001.
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Micro-engineering is nowadays a key industrial area with applications is a wide range of products and sectors. The need for a multiplicity of products fostered the development of several processes and combinations of processes in the world of micro-engineering. There are different feasible alternatives to produce the same kind of product. The manufacturing cost is usually the decision factor to select the best alternative among them. But cost is affected by dozens of factors and if not properly modelled causes controversy in so complex decisions. In this chapter, the application of process-based cost modelling is proposed as the engine to identify the best performance spaces for each alternative, using its potential for sensitive analysis of uncertain and/or critical parameters. To illustrate the approach, a case study is developed analyzing four alternatives for the production of a light diffuser with micro-features imbibed, involving micro-injection molding, hot-embossing, micromachining, and powder-injection molding.
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Lee, Jui-Yuan, Pei-Fan Bai, Raymond E. H. Ooi, Dominic C. Y. Foo, and Raymond R. Tan. "Planning of non-conventional gas field development with parametric uncertainties." In 31st European Symposium on Computer Aided Process Engineering, 1865–70. Elsevier, 2021. http://dx.doi.org/10.1016/b978-0-323-88506-5.50289-8.
Full textConference papers on the topic "Non-conventional development"
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"Evaluation Tools for R&D Projects Sponsored by the Brazilian National Network for Bamboo’s Research and Development – Redebambu/Br." In Non-Conventional Materials and Technologies. Materials Research Forum LLC, 2018. http://dx.doi.org/10.21741/9781945291838-19.
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Chatterjee, Shamba, and Satyaki Bal. "Biofuel from microalgae for sustainable development." In 2014 1st International Conference on Non Conventional Energy (ICONCE). IEEE, 2014. http://dx.doi.org/10.1109/iconce.2014.6808699.
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Purohit, Harsh, Ankit Shah, Nishant Parekh, and Akash Pandey. "Development Concept for Non Conventional Hybrid Engine." In ASME 2010 International Mechanical Engineering Congress and Exposition. ASMEDC, 2010. http://dx.doi.org/10.1115/imece2010-39960.
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Environmental issues and the need for environment-friendly transport have always been a priority for the world due to ever increasing demand of modes of transport. So developing quick and eco friendly vehicle is the trend as of now with most manufacturers globally. There are numerous ways in which manufacturers have tackled these issues. Some of the common approaches undertaken are refinements of existing internal combustion engines. Like developing technologies such as direct injection, VVT (variable valve time), VTEC (variable valve time electronic lift), VGT (variable geometry turbines), reducing engine friction and weight, cam less engines, micro hybrids, etc But the best/optimum compromise between eco friendliness and urge to develop more power with good fuel economy and reduced emission is best met by the development of hybrid engines. Thermal and electric engines both have advantages and disadvantages that are often complementary. Combustion engines offer better range, power and ‘lunge’, but give out exhaust gas, although the current Euro IV norm place strict limits on these. Electric engines are zero-emission and offer very quick pick-up from a stopped position, but the batteries have low range and limited speed. So this complementation of both power trains is exploited in hybrid engines. Now conventional hybrids have many disadvantages such as being bulky with additional weight of battery packs and motors and other auxiliary transmission components, complex and dangerous electric systems, etc. So it is proposed to develop a non conventional hybrid engine which produces power at par with the conventional one and releases emission which is compatible with the stringent emission norms set for the conventional hybrids with considerably lucrative fuel economy comparable with the currently available hybrids in market and yet overcome the drawbacks of the conventional hybrid engines. Also the compact size of the hybrid engine that we propose makes it quite viable to fitted in small vehicles (like bikes, compact cars, etc) which further makes it a more promising technology that can be made available to common people across the globe and there by lead to a better transportation system for people of all class and need. The conceptualization basically includes modification of an inline twin cylinder or a v-twin 4-stroke gasoline engine as a preliminary step towards achieving the above proposed objectives.
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Saha, Sourav, Sanjid Chowdhury, Md Nahid Hasan, Md Nabayet Zilani, and Intekhab Alam. "Development of a low cost vertical axis wind turbine to study the prospect of wind power in Dhaka, Bangladesh." In 2014 1st International Conference on Non Conventional Energy (ICONCE). IEEE, 2014. http://dx.doi.org/10.1109/iconce.2014.6808709.
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Paulo, Cezar A., Mauro Euphemio, Fernando J. M. Paulo, Pedro da S. Oliveira, and Jose E. Mendonça. "Deepwater Field Development - Combination of Mature and Non-conventional Technologies." In Offshore Technology Conference. Offshore Technology Conference, 2001. http://dx.doi.org/10.4043/12968-ms.
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Ellison, April L., and David H. Timm. "Speed and Temperature Effects on Full-Scale Pavement Responses in Non-Conventional Flexible Pavements." In First Congress of Transportation and Development Institute (TDI). Reston, VA: American Society of Civil Engineers, 2011. http://dx.doi.org/10.1061/41167(398)79.
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Riaño Caraza, Juan M., Fernando S. Flores Avila, Iván Faría Rojas, and Luis E. Brito Rodríguez. "Development of a Performance Assessment Model (PAM) for High Complexity Non-Conventional Reservoirs." In ASME 2012 31st International Conference on Ocean, Offshore and Arctic Engineering. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/omae2012-84183.
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Chicontepec is one of the areas with the largest volume of original oil in place in Mexico; however, after more than 30 years of operation, its development has been very limited due to the high geological complexity and low rock quality of their reservoirs. The reservoirs are found in layered sequences of sediments deposited in turbiditic environments which have suffered different degrees of diagenesis, there is a great level of vertical heterogeneity and a very limited level of lateral continuity. The permeability of the reservoir area is in the range of 0.1 to 5 md, depending on the location and degree of diagenesis, with this level of permeability most wells require hydraulic fracturing to be produced economically. The volume of oil originally in place according to the latest certifications is around 130 billion barrels, of which to this date have been produced 200 MMbls, which represents a current recovery factor of 0.15%. In order to accelerate the development of reserves PEMEX has diversified efforts assigning some areas to other companies. This will provide greater ability to assess best practices and technologies. To evaluate the efforts of companies a performance assessment model was designed, which takes into account the integral complexity of each area to be fair in comparing the results obtained for the different areas. The aim of this paper is to describe the methodology used in the developing of the performance evaluation and integral complexity characterization models.
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Mudhalwadkar, Rohini P., and A. A. Ghatol. "Development of non conventional system for HMF detection in Indian honey Instrumentation systems." In 2008 10th International Conference on Control, Automation, Robotics and Vision (ICARCV). IEEE, 2008. http://dx.doi.org/10.1109/icarcv.2008.4795517.
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Leitloff, V., P. Brun, S. de Langle, B. Ilas, R. Darmony, M. Jobert, C. Bertheau, et al. "Testing of IEC 61850 based Functional Protection Chain Using Non-Conventional Instrument Transformers and SAMU." In 13th International Conference on Development in Power System Protection 2016 (DPSP). Institution of Engineering and Technology, 2016. http://dx.doi.org/10.1049/cp.2016.0037.
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Potter, I. J., G. T. Reader, M. Zheng, and R. W. Gustafson. "Development of an IDI Diesel Engine Test Facility for Use with Non-Conventional Atmospheres." In 27th Intersociety Energy Conversion Engineering Conference (1992). 400 Commonwealth Drive, Warrendale, PA, United States: SAE International, 1992. http://dx.doi.org/10.4271/929059.
Full textReports on the topic "Non-conventional development"
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Hicks, Jacqueline. Examples of 'Systems Thinking' Projects in International Development. Institute of Development Studies, March 2022. http://dx.doi.org/10.19088/k4d.2022.067.
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A “systems thinking” (ST) approach generally recognises that international development processes are complex, inter-related, non-linear, and constantly changing. They involve many different types of actors, all with different levels of power. ST change methods try to mirror these qualities, and move away from more conventional project design and implementation that use simple linear input-output-impact project logic. Thus, this rapid literature review seeks to find out what are some examples of ‘systems thinking’ projects in international development. The aim of this rapid review is to provide concrete examples of how ST shows up in the project design and management processes that are typically used by people working in the international development sector. These include project management arrangements, evaluation indicators, results frameworks, budget allocations and procurement, country diagnostics, and the foundational analysis that informs project design. The examples found were mostly extracted from donor project documents. Different definitions of ST may emphasise different elements. An attempt was made to find a range of projects from different sectors, and to go beyond projects that exemplified “Market Systems Development” and “Adaptive Management,” for which there are already repositories of project examples (see Further Resources).The inclusion of the projects in this review does not imply that they were successful, only that they contain some evidence of ST in them. Most of the projects identified have a further library of documents, including evaluations, that give more detailed information about their successes and failures.
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Jury, William A., and David Russo. Characterization of Field-Scale Solute Transport in Spatially Variable Unsaturated Field Soils. United States Department of Agriculture, January 1994. http://dx.doi.org/10.32747/1994.7568772.bard.
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This report describes activity conducted in several lines of research associated with field-scale water and solute processes. A major effort was put forth developing a stochastic continuum analysis for an important class of problems involving flow of reactive and non reactive chemicals under steady unsaturated flow. The field-scale velocity covariance tensor has been derived from local soil properties and their variability, producing a large-scale description of the medium that embodies all of the local variability in a statistical sense. Special cases of anisotropic medium properties not aligned along the flow direction of spatially variable solute sorption were analysed in detail, revealing a dependence of solute spreading on subtle features of the variability of the medium, such as cross-correlations between sorption and conductivity. A novel method was developed and tested for measuring hydraulic conductivity at the scale of observation through the interpretation of a solute transport outflow curve as a stochastic-convective process. This undertaking provided a host of new K(q) relationships for existing solute experiments and also laid the foundation for future work developing a self-consistent description of flow and transport under these conditions. Numerical codes were developed for calculating K(q) functions for a variety of solute pulse outflow shapes, including lognormal, Fickian, Mobile-Immobile water, and bimodal. Testing of this new approach against conventional methodology was mixed, and agreed most closely when the assumptions of the new method were met. We conclude that this procedure offers a valuable alternative to conventional methods of measuring K(q), particularly when the application of the method is at a scale (e.g. and agricultural field) that is large compared to the common scale at which conventional K(q) devices operate. The same problem was approached from a numerical perspective, by studying the feasibility of inverting a solute outflow signal to yield the hydraulic parameters of the medium that housed the experiment. We found that the inverse problem was solvable under certain conditions, depending on the amount of noise in the signal and the degree of heterogeneity in the medium. A realistic three dimensional model of transient water and solute movement in a heterogeneous medium that contains plant roots was developed and tested. The approach taken was to generate a single realization of this complex flow event, and examine the results to see whether features were present that might be overlooked in less sophisticated model efforts. One such feature revealed is transverse dispersion, which is a critically important component in the development of macrodispersion in the longitudinal direction. The lateral mixing that was observed greatly exceeded that predicted from simpler approaches, suggesting that at least part of the important physics of the mixing process is embedded in the complexity of three dimensional flow. Another important finding was the observation that variability can produce a pseudo-kinetic behavior for solute adsorption, even when the local models used are equilibrium.
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Searcy, Stephen W., and Kalman Peleg. Adaptive Sorting of Fresh Produce. United States Department of Agriculture, August 1993. http://dx.doi.org/10.32747/1993.7568747.bard.
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This project includes two main parts: Development of a “Selective Wavelength Imaging Sensor” and an “Adaptive Classifiery System” for adaptive imaging and sorting of agricultural products respectively. Three different technologies were investigated for building a selectable wavelength imaging sensor: diffraction gratings, tunable filters and linear variable filters. Each technology was analyzed and evaluated as the basis for implementing the adaptive sensor. Acousto optic tunable filters were found to be most suitable for the selective wavelength imaging sensor. Consequently, a selectable wavelength imaging sensor was constructed and tested using the selected technology. The sensor was tested and algorithms for multispectral image acquisition were developed. A high speed inspection system for fresh-market carrots was built and tested. It was shown that a combination of efficient parallel processing of a DSP and a PC based host CPU in conjunction with a hierarchical classification system, yielded an inspection system capable of handling 2 carrots per second with a classification accuracy of more than 90%. The adaptive sorting technique was extensively investigated and conclusively demonstrated to reduce misclassification rates in comparison to conventional non-adaptive sorting. The adaptive classifier algorithm was modeled and reduced to a series of modules that can be added to any existing produce sorting machine. A simulation of the entire process was created in Matlab using a graphical user interface technique to promote the accessibility of the difficult theoretical subjects. Typical Grade classifiers based on k-Nearest Neighbor techniques and linear discriminants were implemented. The sample histogram, estimating the cumulative distribution function (CDF), was chosen as a characterizing feature of prototype populations, whereby the Kolmogorov-Smirnov statistic was employed as a population classifier. Simulations were run on artificial data with two-dimensions, four populations and three classes. A quantitative analysis of the adaptive classifier's dependence on population separation, training set size, and stack length determined optimal values for the different parameters involved. The technique was also applied to a real produce sorting problem, e.g. an automatic machine for sorting dates by machine vision in an Israeli date packinghouse. Extensive simulations were run on actual sorting data of dates collected over a 4 month period. In all cases, the results showed a clear reduction in classification error by using the adaptive technique versus non-adaptive sorting.
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Flaishman, Moshe, Herb Aldwinckle, Shulamit Manulis, and Mickael Malnoy. Efficient screening of antibacterial genes by juvenile phase free technology for developing resistance to fire blight in pear and apple trees. United States Department of Agriculture, December 2008. http://dx.doi.org/10.32747/2008.7613881.bard.
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Objectives: The original objectives of this project were to: Produce juvenile-free pear and apple plants and examine their sensitivity to E. amylovora; Design novel vectors, for antibacterial proteins and promoters expression, combined with the antisense TFL1 gene, and transformation of Spadona pear in Israel and Galaxy apple in USA. The original objectives were revised from the development of novel vectors with antibacterial proteins combined with the TFL-1 due to the inefficiency of alternative markes initially evaluated in pear, phoshomannose-isomerase and 2-deoxyglucose-6-phosphate phosphatase and the lack of development of double selection system. The objectives of project were revised to focus primarily on the development additional juvenile free systems by the use of another pear variety and manipulation of the FT gene under the control of several promoters. Based on the results creation of fire blight resistance pear variety was developed by the use of the juvenile free transgenic plant. Background: Young tree seedlings are unable to initiate reproductive organs and require a long period of shoot maturation, known as juvenile phase. In pear, juvenile period can last 5-7 years and it causes a major delay in breeding programs. We isolated the TFL1 gene from Spadona pear (PcTFL1-1) and produced transgenic ‘Spadona’ trees silencing the PcTFL1 gene using a RNAi approach. Transgenic tissue culture ‘Spadona’ pear flowered in vitro. As expected, the expression of the endogenous PcTFL1 was suppressed in the transgenic line that showed precocious flowering. Transgenic plants were successfully rooted in the greenhouse and most of the plants flowered after only 4-8 months, whereas the non-transformed control plants have flowered only after 5-6 years of development. Major achievements: Prior to flower induction, transgenic TFL1-RNAi ‘Spadona’ plants developed a few branches and leaves. Flower production in the small trees suppressed the development of the vegetative branches, thus resulting in compact flowering trees. Flowering was initiated in terminal buds, as described for the Arabidopsis tfl1 mutant. Propagation of the transgenic TFL1-RNAi ‘Spadona’ was performed by bud grafting on 'Betulifolia' rootstock and resulted in compact flowering trees. The transgenic flowering grafted plants were grown in the greenhouse under a long photoperiod for one year, and flowered continuously. Pollination of the transgenic flowers with ‘Costia‘ pear pollen generated fruits of regular shape with fertile F1 seeds. The F1 transgenic seedling grown in the greenhouse formed shoots and produced terminal flowers only five months after germination. In addition, grafted F1 transgenic buds flower and fruit continuously, generating hybrid fruits with regular shape, color and taste. Several pear varieties were pollinated with the transgenic TFL1-RNAi ‘Spadona’ pollen including `Herald Harw` that was reported to have resistance to fire blight diseases. The F-1 hybrid seedlings currently grow in our greenhouse. We conclude that the juvenile-free transgenic ‘Spadona’ pear enables the development of a fast breeding method in pear that will enable us to generate a resistance pear to fire blight. Implications: The research supported by this grant has demonstrated the use of transgenic juvenile free technology in pear. The use of the juvenile free technology for enhancement of conventional breeding in fruit tree will serve to enhance fast breeding systems in pear and another fruit trees.
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Reisch, Bruce, Avichai Perl, Julie Kikkert, Ruth Ben-Arie, and Rachel Gollop. Use of Anti-Fungal Gene Synergisms for Improved Foliar and Fruit Disease Tolerance in Transgenic Grapes. United States Department of Agriculture, August 2002. http://dx.doi.org/10.32747/2002.7575292.bard.
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Original objectives . 1. Test anti-fungal gene products for activity against Uncinula necator, Aspergillus niger, Rhizopus stolonifer and Botrytis cinerea. 2. For Agrobacterium transformation, design appropriate vectors with gene combinations. 3. Use biolistic bombardment and Agrobacterium for transformation of important cultivars. 4. Characterize gene expression in transformants, as well as level of powdery mildew and Botrytis resistance in foliage of transformed plants. Background The production of new grape cultivars by conventional breeding is a complex and time-consuming process. Transferring individual traits via single genes into elite cultivars was proposed as a viable strategy, especially for vegetatively propagated crops such as grapevines. The availability of effective genetic transformation procedures, the existence of genes able to reduce pathogen stress, and improved in vitro culture methods for grapes, were combined to serve the objective of this proposal. Effective deployment of resistance genes would reduce production costs and increase crop quality, and several such genes and combinations were used in this project. Progress The efficacy of two-way combinations of Trichoderma endochitinase (CHIT42), synthetic peptide ESF12 and resveratrol upon the control of growth of Botrytis cinerea and Penicillium digitatum were evaluated in vitro. All pairwise interactions were additive but not synergistic. Per objective 2, suitable vectors with important gene combinations for Agrobacterium transformation were designed. In addition, multiple gene co-transformation by particle bombardment was also tested successfully. In New York, transformation work focused on cultivars Chardonnay and Merlot, while the technology in Israel was extended to 41B, R. 110, Prime, Italia, Gamay, Chardonnay and Velika. Transgenic plant production is summarized in the appendix. Among plants developed in Israel, endochitinase expression was assayed via the MuchT assay using material just 1-5 days after co-cultivation. Plants of cv. Sugraone carrying the gene coding for ESF12, a short anti-fungal lytic peptide under the control of the double 358 promoter, were produced. Leaf extracts of two plants showed inhibition zones that developed within 48 h indicating the inhibitory effect of the leaf extracts on the six species of bacteria. X fastidiosa, the causal organism of Pierce's disease, was very sensitive to leaf extracts from ESF12 transformed plants. Further work is needed to verify the agricultural utility of ESF12 transformants. In New York, some transformants were resistant to powdery mildew and Botrytis fruit rot. Major conclusions, solutions, achievements and implications The following scientific achievements resulted from this cooperative BARD project: 1. Development and improvement of embryogenesis and tissue culture manipulation in grape, while extending these procedures to several agriculturally important cultivars both in Israel and USA. 2. Development and improvement of novel transformation procedures while developing transformation techniques for grape and other recalcitrant species. 3. Production of transgenic grapevines, characterization of transformed vines while studying the expression patterns of a marker gene under the control of different promoter as the 35S CaMV in different part of the plants including flowers and fruits. 4. Expression of anti-fungal genes in grape: establishment of transgenic plants and evaluation of gene expression. Development of techniques to insert multiple genes. 5. Isolation of novel grape specific promoter to control the expression of future antimicrobial genes. It is of great importance to report that significant progress was made in not only the development of transgenic grapevines, but also in the evaluation of their potential for increased resistance to disease as compared with the non engineered cultivar. In several cases, increased disease resistance was observed. More research and development is still needed before a product can be commercialized, yet our project lays a framework for further investigations.
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Warrick, Arthur W., Gideon Oron, Mary M. Poulton, Rony Wallach, and Alex Furman. Multi-Dimensional Infiltration and Distribution of Water of Different Qualities and Solutes Related Through Artificial Neural Networks. United States Department of Agriculture, January 2009. http://dx.doi.org/10.32747/2009.7695865.bard.
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The project exploits the use of Artificial Neural Networks (ANN) to describe infiltration, water, and solute distribution in the soil during irrigation. It provides a method of simulating water and solute movement in the subsurface which, in principle, is different and has some advantages over the more common approach of numerical modeling of flow and transport equations. The five objectives were (i) Numerically develop a database for the prediction of water and solute distribution for irrigation; (ii) Develop predictive models using ANN; (iii) Develop an experimental (laboratory) database of water distribution with time; within a transparent flow cell by high resolution CCD video camera; (iv) Conduct field studies to provide basic data for developing and testing the ANN; and (v) Investigate the inclusion of water quality [salinity and organic matter (OM)] in an ANN model used for predicting infiltration and subsurface water distribution. A major accomplishment was the successful use of Moment Analysis (MA) to characterize “plumes of water” applied by various types of irrigation (including drip and gravity sources). The general idea is to describe the subsurface water patterns statistically in terms of only a few (often 3) parameters which can then be predicted by the ANN. It was shown that ellipses (in two dimensions) or ellipsoids (in three dimensions) can be depicted about the center of the plume. Any fraction of water added can be related to a ‘‘probability’’ curve relating the size of the ellipse (or ellipsoid) that contains that amount of water. The initial test of an ANN to predict the moments (and hence the water plume) was with numerically generated data for infiltration from surface and subsurface drip line and point sources in three contrasting soils. The underlying dataset consisted of 1,684,500 vectors (5 soils×5 discharge rates×3 initial conditions×1,123 nodes×20 print times) where each vector had eleven elements consisting of initial water content, hydraulic properties of the soil, flow rate, time and space coordinates. The output is an estimate of subsurface water distribution for essentially any soil property, initial condition or flow rate from a drip source. Following the formal development of the ANN, we have prepared a “user-friendly” version in a spreadsheet environment (in “Excel”). The input data are selected from appropriate values and the output is instantaneous resulting in a picture of the resulting water plume. The MA has also proven valuable, on its own merit, in the description of the flow in soil under laboratory conditions for both wettable and repellant soils. This includes non-Darcian flow examples and redistribution and well as infiltration. Field experiments were conducted in different agricultural fields and various water qualities in Israel. The obtained results will be the basis for the further ANN models development. Regions of high repellence were identified primarily under the canopy of various orchard crops, including citrus and persimmons. Also, increasing OM in the applied water lead to greater repellency. Major scientific implications are that the ANN offers an alternative to conventional flow and transport modeling and that MA is a powerful technique for describing the subsurface water distributions for normal (wettable) and repellant soil. Implications of the field measurements point to the special role of OM in affecting wettability, both from the irrigation water and from soil accumulation below canopies. Implications for agriculture are that a modified approach for drip system design should be adopted for open area crops and orchards, and taking into account the OM components both in the soil and in the applied waters.
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Galili, Naftali, Roger P. Rohrbach, Itzhak Shmulevich, Yoram Fuchs, and Giora Zauberman. Non-Destructive Quality Sensing of High-Value Agricultural Commodities Through Response Analysis. United States Department of Agriculture, October 1994. http://dx.doi.org/10.32747/1994.7570549.bard.
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The objectives of this project were to develop nondestructive methods for detection of internal properties and firmness of fruits and vegetables. One method was based on a soft piezoelectric film transducer developed in the Technion, for analysis of fruit response to low-energy excitation. The second method was a dot-matrix piezoelectric transducer of North Carolina State University, developed for contact-pressure analysis of fruit during impact. Two research teams, one in Israel and the other in North Carolina, coordinated their research effort according to the specific objectives of the project, to develop and apply the two complementary methods for quality control of agricultural commodities. In Israel: An improved firmness testing system was developed and tested with tropical fruits. The new system included an instrumented fruit-bed of three flexible piezoelectric sensors and miniature electromagnetic hammers, which served as fruit support and low-energy excitation device, respectively. Resonant frequencies were detected for determination of firmness index. Two new acoustic parameters were developed for evaluation of fruit firmness and maturity: a dumping-ratio and a centeroid of the frequency response. Experiments were performed with avocado and mango fruits. The internal damping ratio, which may indicate fruit ripeness, increased monotonically with time, while resonant frequencies and firmness indices decreased with time. Fruit samples were tested daily by destructive penetration test. A fairy high correlation was found in tropical fruits between the penetration force and the new acoustic parameters; a lower correlation was found between this parameter and the conventional firmness index. Improved table-top firmness testing units, Firmalon, with data-logging system and on-line data analysis capacity have been built. The new device was used for the full-scale experiments in the next two years, ahead of the original program and BARD timetable. Close cooperation was initiated with local industry for development of both off-line and on-line sorting and quality control of more agricultural commodities. Firmalon units were produced and operated in major packaging houses in Israel, Belgium and Washington State, on mango and avocado, apples, pears, tomatoes, melons and some other fruits, to gain field experience with the new method. The accumulated experimental data from all these activities is still analyzed, to improve firmness sorting criteria and shelf-life predicting curves for the different fruits. The test program in commercial CA storage facilities in Washington State included seven apple varieties: Fuji, Braeburn, Gala, Granny Smith, Jonagold, Red Delicious, Golden Delicious, and D'Anjou pear variety. FI master-curves could be developed for the Braeburn, Gala, Granny Smith and Jonagold apples. These fruits showed a steady ripening process during the test period. Yet, more work should be conducted to reduce scattering of the data and to determine the confidence limits of the method. Nearly constant FI in Red Delicious and the fluctuations of FI in the Fuji apples should be re-examined. Three sets of experiment were performed with Flandria tomatoes. Despite the complex structure of the tomatoes, the acoustic method could be used for firmness evaluation and to follow the ripening evolution with time. Close agreement was achieved between the auction expert evaluation and that of the nondestructive acoustic test, where firmness index of 4.0 and more indicated grade-A tomatoes. More work is performed to refine the sorting algorithm and to develop a general ripening scale for automatic grading of tomatoes for the fresh fruit market. Galia melons were tested in Israel, in simulated export conditions. It was concluded that the Firmalon is capable of detecting the ripening of melons nondestructively, and sorted out the defective fruits from the export shipment. The cooperation with local industry resulted in development of automatic on-line prototype of the acoustic sensor, that may be incorporated with the export quality control system for melons. More interesting is the development of the remote firmness sensing method for sealed CA cool-rooms, where most of the full-year fruit yield in stored for off-season consumption. Hundreds of ripening monitor systems have been installed in major fruit storage facilities, and being evaluated now by the consumers. If successful, the new method may cause a major change in long-term fruit storage technology. More uses of the acoustic test method have been considered, for monitoring fruit maturity and harvest time, testing fruit samples or each individual fruit when entering the storage facilities, packaging house and auction, and in the supermarket. This approach may result in a full line of equipment for nondestructive quality control of fruits and vegetables, from the orchard or the greenhouse, through the entire sorting, grading and storage process, up to the consumer table. The developed technology offers a tool to determine the maturity of the fruits nondestructively by monitoring their acoustic response to mechanical impulse on the tree. A special device was built and preliminary tested in mango fruit. More development is needed to develop a portable, hand operated sensing method for this purpose. In North Carolina: Analysis method based on an Auto-Regressive (AR) model was developed for detecting the first resonance of fruit from their response to mechanical impulse. The algorithm included a routine that detects the first resonant frequency from as many sensors as possible. Experiments on Red Delicious apples were performed and their firmness was determined. The AR method allowed the detection of the first resonance. The method could be fast enough to be utilized in a real time sorting machine. Yet, further study is needed to look for improvement of the search algorithm of the methods. An impact contact-pressure measurement system and Neural Network (NN) identification method were developed to investigate the relationships between surface pressure distributions on selected fruits and their respective internal textural qualities. A piezoelectric dot-matrix pressure transducer was developed for the purpose of acquiring time-sampled pressure profiles during impact. The acquired data was transferred into a personal computer and accurate visualization of animated data were presented. Preliminary test with 10 apples has been performed. Measurement were made by the contact-pressure transducer in two different positions. Complementary measurements were made on the same apples by using the Firmalon and Magness Taylor (MT) testers. Three-layer neural network was designed. 2/3 of the contact-pressure data were used as training input data and corresponding MT data as training target data. The remaining data were used as NN checking data. Six samples randomly chosen from the ten measured samples and their corresponding Firmalon values were used as the NN training and target data, respectively. The remaining four samples' data were input to the NN. The NN results consistent with the Firmness Tester values. So, if more training data would be obtained, the output should be more accurate. In addition, the Firmness Tester values do not consistent with MT firmness tester values. The NN method developed in this study appears to be a useful tool to emulate the MT Firmness test results without destroying the apple samples. To get more accurate estimation of MT firmness a much larger training data set is required. When the larger sensitive area of the pressure sensor being developed in this project becomes available, the entire contact 'shape' will provide additional information and the neural network results would be more accurate. It has been shown that the impact information can be utilized in the determination of internal quality factors of fruit. Until now,
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Exploring the Prospects of Using 3D Printing Technology in the South African Human Settlements. Academy of Science of South Africa (ASSAf), 2021. http://dx.doi.org/10.17159/assaf.2021/0074.
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South Africa is a country with significant socio-economic development challenges, with the majority of South Africans having limited or non-existent access to basic infrastructure, services, housing and socio-economic opportunities etc. The urban housing backlog currently exceeds 2.4 million houses, with many families living in informal settlements. The Breaking New Grounds Policy, 2014 for the creation of sustainable human settlements, acknowledges the challenges facing human settlements, such as, decreasing human settlements grants allocation, increasing housing backlog, mushrooming of informal settlements and urbanisation. The White Paper on Science, Technology and Innovation (STI), 2019 notes that South Africa has not yet fully benefited from the potential of STI in addressing the socio-economic challenges and seeks to support the circular economy principles which entail a systematic change of moving to a zero or low waste resource-efficient society. Further to this, the Science and Technology Roadmap’s intention is to unlock the potential of South Africa’s human settlements for a decent standard of living through the smart uptake of science, technology and innovation. One such novel technology is the Three-Dimensional (3D) printing technology, which has produced numerous incredible structures around the world. 3D printing is a computer-controlled industrial manufacturing process which encompasses additive means of production to create 3D shapes. The effects of such a technology have a potential to change the world we live in and could subsequently pave the roadmap to improve on housing delivery and reduce the negative effects of conventional construction methods on the environment. To this end, the Academy of Science of South Africa (ASSAf), in partnership with the Department of Science and Innovation (DSI) and the University of Johannesburg (UJ) hosted the second virtual IID seminar titled: Exploring the Prospects of Using 3D Printing Technology in the South African Human Settlements, on 01 March 2021 to explore the potential use of 3D printing technology in human settlements. The webinar presented preliminary findings from a study conducted by UJ, addressing the following topics: 1. The viability of 3D printing technology 2. Cost comparison of 3D printed house to conventional construction 3. Preliminary perceptions on 3D printing of houses Speakers included: Dr Jennifer Mirembe (NDoHS), Dr Jeffrey Mahachi, Mr Refilwe Lediga, Mr Khululekani Ntakana and Dr Luxien Ariyan, all from UJ. There was a unanimous consensus that collaborative efforts from all stakeholders are key to take advantage of this niche technology. @ASSAf_Official; @dsigovza; @go2uj; @The_DHS; #SA 3D_Printing; #3D Print_Housing; #IID