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Academic literature on the topic 'Nodal metastase'

Author: Grafiati

Published: 9 March 2023

Last updated: 10 March 2023

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Journal articles on the topic "Nodal metastase"

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Rouzier, Roman, Jean-Marc Extra, Mathieu Carton, Marie-Christine Falcou, Anne Vincent-Salomon, Alain Fourquet, Pierre Pouillart, and Edwige Bourstyn. "Primary Chemotherapy for Operable Breast Cancer: Incidence and Prognostic Significance of Ipsilateral Breast Tumor Recurrence After Breast-Conserving Surgery." Journal of Clinical Oncology 19, no. 18 (September 15, 2001): 3828–35. http://dx.doi.org/10.1200/jco.2001.19.18.3828.

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PURPOSE: To determine the incidence and the prognostic value of ipsilateral breast tumor recurrence (IBTR) in patients treated with primary chemotherapy and breast-conserving surgery. PATIENTS AND METHODS: Between January 1985 and December 1994, 257 patients with invasive T1 to T3 breast carcinoma were treated with primary chemotherapy, lumpectomy, and radiation therapy. The median follow-up time was 93 months. To evaluate the role of IBTR in metastase-free survival, a Cox regression multivariate analysis was performed using IBTR as a time-dependent covariate. RESULTS: The IBTR rates were 16% (± 2.4%) at 5 years and 21.5% (± 3.2%) at 10 years. Multivariate analysis showed that the probability of local control was decreased by the following independent factors: age ≤ 40 years, excision margin ≤ 2 mm, S-phase fraction more than 4%, and clinical tumor size more than 2 cm at the time of surgery. In patients with excision margins of more than 2 mm, the IBTR rates were 12.7% at 5 years and 17% at 10 years. Nodal status, age ≤ 40 years, and negative estrogen receptor status were predictors of distant disease in the Cox multivariate model with fixed covariates. The contribution of IBTR was highly significant (relative risk = 5.34) when added to the model, whereas age ≤ 40 years was no longer significant. After IBTR, 31.4% (± 7.0%) of patients developed metastases at 2 years and 59.7% (± 8.1%) at 5 years. Skin involvement, size at initial surgery, and estrogen receptor status were predictors of metastases after IBTR. CONCLUSION: IBTR is a strong predictor for distant metastases. There are implications for conservative surgery after downstaging of the tumor and therapy at the time of IBTR.

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Yang, Hong. "RA07.05: DIAGNOSTIC VALUE OF INTRAOPERATIVE ULTRASONOGRAPHY IN ASSESSING THORACIC RECURRENT LARYNGEAL NERVE LYMPH NODES IN PATIENTS WITH ESOPHAGEAL CANCER." Diseases of the Esophagus 31, Supplement_1 (September 1, 2018): 35. http://dx.doi.org/10.1093/dote/doy089.ra07.05.

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Abstract Background To evaluate the ability of intraoperative ultrasonography (IU) to detect recurrent laryngeal nerve (RLN) nodal metastases in esophageal cancer patients. Methods Sixty patients with esophageal cancer underwent IU, computed tomography (CT), and endoscopic ultrasonography (EUS) to assess for RLN nodal metastasis. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were compared. Results The sensitivities of IU, CT, and EUS in diagnosing right RLN nodal metastases were 71.4%, 14.3%, and 30.0%, respectively, and a significant difference among these three examinations was observed (c2 = 10.077, P = .006). The specificities of IU, CT, and EUS for diagnosing right RLN nodal metastasis were 67.4%, 97.8%, and 95.0%, respectively, and a significant difference was observed (c2 = 21.725, P < .001). No significant differences in either PPV or NPV were observed when diagnosing right RLN nodal metastases. For diagnosis of left RLN lymph nodal metastases, the sensitivities of IU, CT, and EUS were 91.7%, 16.7%, and 40.0% respectively. There was a significant difference among these diagnostic sensitivities (c2 = 14.067, P = .001). The specificities of IU, CT, and EUS for diagnosis of left RLN nodal metastases were 79.2%, 100%, and 82.5%, respectively and a significant difference was observed (c2 = 10.819, P = .004). No significant differences were observed in PPV or NPV for these examinations when diagnosing left RLN nodal metastases. Conclusion Intraoperative ultrasonography showed superior sensitivity compared with preoperative CT or EUS in detecting RLN lymph node metastasis in patients with thoracic esophageal cancer. Disclosure All authors have declared no conflicts of interest.

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Abu-Zaid, Ahmed, Ayman Azzam, Hindi Al-Hindi, and Tarek Amin. "Femoral Pathological Fracture as the First Clinical Manifestation of Papillary Thyroid Carcinoma in a Primigravida." Case Reports in Pathology 2013 (2013): 1–4. http://dx.doi.org/10.1155/2013/397361.

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Papillary thyroid carcinoma is the most common differentiated type of thyroid malignancy. It is largely a loco-regional disease with a high tendency to metastasize to regional cervical lymph nodes. Distant hematogenous metastases are very rare and primarily include lungs and bones. Distant bone metastases are present in approximately 1.7% of patients with differentiated thyroid malignancy. Sternum, ribs, and spine are the most frequent sites of osseous metastases. Up to our knowledge, we report the first occurrence of an extra nodal metastasis of papillary thyroid carcinoma to a femoral bone presenting as a pathological fracture in a 21-year-old 37-week primigravida. We report this case because of its unusual site of metastasis and atypical presentation during pregnancy. Moreover, we briefly elaborate on the management of such uncommon cases.

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Ide, Taketoshi, Takamichi Ito, Maiko Wada-Ohno, and Masutaka Furue. "Preoperative Screening CT and PET/CT Scanning for Acral Melanoma: Is it Necessary?" Journal of Clinical Medicine 10, no. 4 (February 17, 2021): 811. http://dx.doi.org/10.3390/jcm10040811.

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The efficacy of preoperative imaging for acral melanoma (AM) has not been fully evaluated. We examined the accuracy of imaging modalities in the detection of nodal and distant metastases in patients with AM. A retrospective review of 109 patients with AM was performed. All patients had no clinical signs suggestive of distant metastases, and underwent preoperative screening computed tomography (CT) and positron emission tomography (PET)/CT scans. Of 100 patients without lymphadenopathy, 17 patients were suspected of having nodal metastasis in CT and PET/CT, but only two of them were confirmed on histopathological analysis. On the other hand, 12 out of 83 negatively imaged patients showed histopathological signs of nodal metastasis; thus, the sensitivity and specificity of nodal detection were 14.3% and 82.6%, respectively. Regard to the detection of distant metastases, four patients were suspected of having metastasis, but this was later ruled out. The remaining 96 negatively imaged patients were confirmed to have no metastasis at the time of CT and PET/CT by the follow-up. In contrast, distant metastases were found by CT and PET/CT in four of nine patients (44.4%) with lymphadenopathy. Routine preoperative CT and PET/CT for AM patients without lymphadenopathy may not be warranted because of low sensitivity and specificity, but it can be considered for those with lymphadenopathy.

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Marchegiani, Giovanni, Luca Landoni, Stefano Andrianello, Gaia Masini, Sara Cingarlini, Mirko D’Onofrio, Riccardo De Robertis, et al. "Patterns of Recurrence after Resection for Pancreatic Neuroendocrine Tumors: Who, When, and Where?" Neuroendocrinology 108, no. 3 (November 27, 2018): 161–71. http://dx.doi.org/10.1159/000495774.

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Background/Aims: Pancreatic neuroendocrine tumors (pan-NENs) represent an increasingly common indication for pancreatic resection, but there are few data regarding possible recurrence after surgery. The aim of the study was to describe the frequency, timing, and patterns of recurrence after resection for pan-NENs with consequent implications for postoperative follow-up. Methods: We performed a retrospective analysis of pan-NENs resected between 1990 and 2015 at The Pancreas Institute, University of Verona Hospital Trust. Predictors of recurrence were assessed. Survival analysis was conducted using the Kaplan-Meier and conditional survival (CS) methods. Results: The cohort consisted of 487 patients with a median follow-up of 71 months. Recurrence developed in 12.3%: 54 (11.1%) liver metastases, 11 (2.3%) local recurrence, 10 (2.1%) nodal recurrence, and 8 (1.6%) metastases in other organs. Thirty-one (6.4%) died due to disease recurrence. Size > 21 mm, G3 grade, nodal metastasis, and vascular infiltration were independent predictors of overall recurrence. Recurrence occurred either during the first year of follow-up (n = 9), or after 10 years (n = 4). CS analysis revealed that nonfunctioning G1 pan-NEN ≤20 mm without nodal metastasis or vascular invasion had a negligible risk of developing recurrence. In the present series, after 5 years of follow-up without developing recurrence, tumor recurrence occurred only in the form of liver metastases. Conclusions: Recurrence of pan-NENs is rare and is predicted by tumor size, nodal metastasis, grading, and vascular invasion. Patients with G1 pan-NEN without nodal metastasis and vascular invasion may be considered cured by surgery. After 5 years without recurrence, follow-up should focus on excluding the development of liver metastases.

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Haidari, Selgai, Katharina Theresa Obermeier, Moritz Kraus, Sven Otto, Florian Andreas Probst, and Paris Liokatis. "Nodal Disease and Survival in Oral Cancer: Is Occult Metastasis a Burden Factor Compared to Preoperatively Nodal Positive Neck?" Cancers 14, no. 17 (August 31, 2022): 4241. http://dx.doi.org/10.3390/cancers14174241.

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The impact of neck involvement and occult metastasis (OM) in patients with oral squamous cell carcinoma (OSCC) favors an elective neck dissection. However, there are barely any existing data on survival for patients with OM compared with patients with positive lymph nodes detected preoperatively. This study aims to compare survival curves of patients suffering from lymph nodal metastases in a preoperatively N+ neck with those suffering from OM. In addition, clinical characteristics of the primary tumor were analyzed to predict occult nodal disease. This retrospective cohort study includes patients with an OSCC treated surgically with R0 resection with or without adjuvant chemoradiotherapy between 2010 and 2016. Minimum follow-up was 60 months. Kaplan–Meier analysis was used to compare the survival between patients with and without occult metastases and patients with N+ neck to those with occult metastases. Logistic regression was used to detect potential risk factors for occult metastases. The patient cohort consisted of 226 patients. Occult metastases occurred in 16 of 226 patients. In 53 of 226 patients, neck lymph nodes were described as suspect on CT imaging but had a pN0 neck. Higher tumor grading increased the chance of occurrence of occult metastasis 2.7-fold (OR = 2.68, 95% CI: 1.07–6.7). After 12, 24, 48 and 60 months, 82.3%, 73.8%, 69% and 67% of the N0 patients, respectively, were progression free. In the group with OM occurrence, for the same periods 66.6%, 50%, 33.3% and 33.3% of the patients, respectively, were free of disease. For the same periods, respectively, 81%, 63%, 47% and 43% of the patients in the N+ group but without OM remained disease free. The predictors for progression-free survival were a positive N status (HR = 1.44, 95% CI: 1.08–1.93) and the occurrence of OM (HR = 2.33, 95% CI: 1.17–4.64). The presence of occult metastasis could lead to decreased survival and could be a burdening factor requiring treatment escalation and a more aggressive follow-up than nodal disease detected in the preoperative diagnostic imaging.

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Kandagatla, Pridvi, Lilias H. Maguire, and Karin M. Hardiman. "Biology of Nodal Spread in Colon Cancer: Insights from Molecular and Genetic Studies." European Surgical Research 59, no. 5-6 (2018): 361–70. http://dx.doi.org/10.1159/000494832.

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Colorectal cancer (CRC) lymph node metastases are common but their genetics and the mechanism whereby these metastases occur are not well understood. Here we present recent data regarding genetic heterogeneity in primary CRCs and their metastasis. In addition, we explain the different potential models describing the mechanisms of metastasis and the data supporting them. Multiple studies have also revealed a variety of prognostic molecular markers that are associated with lymph node metastasis in CRC. A better understanding of genetic heterogeneity and the mechanisms of metastasis is critical to predicting clinical response and resistance to targeted therapy.

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Kowalski, Luiz P., and Jesus E. Medina. "NODAL METASTASES." Otolaryngologic Clinics of North America 31, no. 4 (August 1998): 621–37. http://dx.doi.org/10.1016/s0030-6665(05)70076-1.

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Russell, Maria C., Yj Chiang, Barry W. Feig, George J. Chang, Miguel A. Rodriguez-Bigas, John Michael Skibber, Ryaz Chagpar, Janice N. Cormier, and Y. Nancy You. "Lymph node metastasis in patients with early pathologic T-stage rectal cancers: What does local excision leave behind?" Journal of Clinical Oncology 30, no. 4_suppl (February 1, 2012): 537. http://dx.doi.org/10.1200/jco.2012.30.4_suppl.537.

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537 Background: As the interest in local excision (LE) for rectal cancer increases, the risk of residual nodal disease and local failure must be considered. We utilized a nationwide cancer registry to establish incidence and predictors of nodal metastasis in early pathologic T stage rectal cancers. Methods: Early path T stage rectal cancers (1998-2007) were identified from the National Cancer Database (NCDB), including pT1-2 tumors in patients not receiving neoadjuvant therapy (NT), or ypT0-2 tumors after NT. Proctectomy was performed in 22,416 (74.7%) and LE in 7,589 (25.3%) without NT. After NT, 7,481 (96.1%) underwent proctectomy and 300 (3.9%) LE. Nodal metastasis rates were calculated from proctectomy patients. Factors associated with nodal metastases were analyzed among those with ≥12 nodes assessed. Results: The incidence of nodal positivity was 12.5% for pT1 and 26.8% for pT2 tumors. Among those with ≥12 nodes examined, these rates increased to 16.9% and 28.6% respectively. After receiving NT, nodal positivity rates were 8.6% for ypT0, 12.9% for ypT1, and 21.4% for ypT2 tumors. These rates increased to 13.5%, 16.9% and 28.3% respectively when ≥12 nodes examined. In multivariate analysis, female sex, age <50, higher T stage, higher histologic grade, mucinous/signet-ring features, and more than 12 nodes examined were all significantly associated with nodal metastases in both groups ( Table ). Conclusions: Among rectal cancers of early path T stages, the risk of nodal metastasis increases with higher path T stage and with greater number of nodes examined, regardless of receipt of NT. These findings must be carefully deliberated, given the current interests in expanding the role of LE based on pathologic T stage of rectal cancer. [Table: see text]

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Kumar, Praveen, Nishikant Avinash Damle, Sandeep Agarwala, Sada Nand Dwivedi, and Chandrasekhar Bal. "Individualized dosimetry in children and young adults with differentiated thyroid cancer undergoing iodine-131 therapy." Journal of Pediatric Endocrinology and Metabolism 33, no. 8 (August 27, 2020): 1031–44. http://dx.doi.org/10.1515/jpem-2020-0072.

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AbstractObjectivesThe amount of Iodine-131 to treat young patients with differentiated thyroid cancer (DTC) has not been established so far. The purpose of this study was to perform and compare blood dosimetry by “Hanscheid’s approach”and lesion dosimetry by “Maxon’s approach”.MethodsSeventy-one DTC patients ≤21 years were given diagnostic activity of 74 MBq 131I followed by whole-body scan (WBS) at 2 h (pre-void), 24 h, 48 h, and ≥72 h. Pre-therapy blood and lesion dosimetry were conducted to determine the absorbed doses to blood and lesions and to predict the therapeutic activity. The administered activities were varied from 1.11–5.55 GBq of 131I depending on disease extent. Post therapy dosimetries were again performed by acquiring WBS data at 24 h, 48 h, and ≥72 h.ResultsIn blood dosimetry, the difference between predicted therapy activity (PTA) and actual therapeutic activity (ATA) was statistically significant in remnant and lung lesions but insignificant in nodal metastases (p=0.287). In lesion dosimetry, the difference between PTA and ATA was statistically significant for lung metastasis patients; however, not significant in remnant (p=0.163) and nodal metastases (p=0.054). The difference between predicted and observed absorbed dose was insignificant in blood dosimetry whereas, significant in lesion dosimetry.ConclusionsThe PTA based on 0.3 Gy recommendations of Hanscheid et al. may be adequate for patients with remnant or nodal metastases but inadequate for lung metastases. Lesion dosimetry demonstrated that there is scope to decrease the 131I empiric ATA for remnant and nodal metastases; at the same time, there is scope to increase in lung metastasis patients.

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Dissertations / Theses on the topic "Nodal metastase"

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Baier, Patricia Maria Gloria. "Prognostische Bedeutung der CEA- und CK-20-Detektion mittels RT-PCR in peritumoralen Lymphknoten von Patienten mit nodal negativem kolorektalen Karzinom im UICC-Stadium I und II." [S.l.] : [s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=972767304.

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CHITI, LAVINIA ELENA. "GAMMA-PROBE GUIDED SENTINEL LYMPH NODE EXTIRPATION TO ASSESS PATTERNS OF NODAL METASTASIS IN SPONTANEOUS HEAD AND NECK MALIGNANCIES OF THE DOG: A SECOND STEP BASED ON PREVIOUS EXPERIENCES ON MAST-CELL TUMORS." Doctoral thesis, Università degli Studi di Milano, 2022. http://hdl.handle.net/2434/916665.

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Canine oncology has recently reported interest in the detection of occult nodal metastases, and efforts have been made to identify the best strategy for accurate nodal staging. In this scenario, the present PhD thesis was aimed to improve knowledge on the current understanding of the feasibility and impact of sentinel lymph node (SLN) mapping with radiopharmaceutical and blue dye in cancer-bearing dogs. Initially, we evaluated the technique in canine mast cell tumors (MCT), given the high prevalence of this tumor type, the propensity for lymphatic spread and recognized prognostic impact of nodal metastases. Thirty client-owned dogs with 34 MCT were included. At least one SLN was identified in all but 3 dogs that had a scar from previously excised MCT, and in 30 cases (63%) the SLN did not correspond to the regional lymph node (RLN). As a second step, we explored the impact of SLN mapping and extirpation in dogs with head and neck tumors, given the well-accepted unpredictability of patterns of nodal metastases. Twenty-three dogs with tumors of the head and neck and absence of clinically evident nodal disease (cN0 neck) were prospectively included and underwent tumor excision and SLN extirpation. Reported detection rate was 83%, with at least one SLN identified in all but 4 dogs with thyroid tumors. In 52% of dogs, the SLN did not correspond to the RLN and at histopathology 42% of dogs had nodal metastases, of which 4 differed from the RLN. As the last step of this PhD project, we conducted an explorative study to identify clinical or pathological characteristics that could allow for identification of dogs with MCT at lower risk of SLN metastases, that could be excluded a priori from the SLN mapping and extirpation. Surprisingly, tumor grade was not able to predict the risk of having HN2-3 or HN3 SLN and the only variables that correlated with nodal metastases were tumor size, number or SLN and subcutaneous MCT. Given low to moderate discriminant ability, however, none of these variables could safely determine the exclusion of patients from the procedure. Results of the present project underscore the utility of implementation of SLN biopsy in the management of dogs with MCT and head and neck tumors, given the low correspondence between clinically expected RLN and SLN and the high rate of occult nodal metastases that could be detected with this procedure. Future research should be aimed at investigating the impact on long-term prognosis and disease free interval of the extirpation of metastatic SLN, and identify variables that could allow for exclusion of low-risk patients from the procedure.

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Davids, Virginia. "Molecular detection of melanoma nodal metastases." Master's thesis, University of Cape Town, 2002. http://hdl.handle.net/11427/3375.

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Includes bibliography.
The aim of this study was to develop a practical and reproducible multi-marker RT-PCR essay, with the emphasis on achieving maximum specificity for the detection of melanoma nodal metastases. A novel protocol for the efficient homogenisation of nodal tissue was developed, with clinical applicability as the objective.

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Wiener, Martin. "Lymphatic mapping and occult nodal metastasis in melanoma." Thesis, University of Sheffield, 2016. http://etheses.whiterose.ac.uk/13621/.

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Around 20% of patients, diagnosed with a clinically localized primary cutaneous melanoma, have occult lymph node metastases. Lymphatic mapping and sentinel node biopsy, using pre-operative lymphoscintigraphy, intra-operative blue dye injection and gamma probe localization, in most cases identifies the node or nodes most likely to contain occult metastases, if present. The presence or absence of such metastases is the most powerful prognostic indicator in this group of patients. However, a number of other factors related to the patient and the primary melanoma can be used to determine prognosis. It is therefore important that the quality of lymphatic mapping is maximized and information gained from sentinel node biopsy is used to best effect, so that advice and treatment can be tailored to the individual patient. The studies contained within this thesis represent an attempt to improve the quality and individualization of care. The technique of lymphatic mapping using lymphoscintigraphy has been critically analysed to identify sources of inaccuracy. The frequency and causes of failure to identify sentinel nodes using lymphoscintigraphy have been determined in a large series of patients. The lymphatic drainage patterns from the head and neck have been investigated, using the forehead and its subdivisions, in order to produce new recommendations for selective neck dissection. The relative importance of clinical and pathological factors in sentinel node positive patients and the significance of nodal metastasis beyond sentinel nodes have been determined. A new prognostic classification or survival tree has been developed for patients with occult nodal metastases and then validated in a separate population. This allows four distinct prognostic groups with 5-year survival ranging from over 90% to around 20% to be identified. The prognostic groups differentiate patients who are at high and low risk of having occult distant metastases and so could be used to select patients for entry into clinical trials of adjuvant therapies as well as to determine who should receive existing adjuvant therapies. The survival tree has been compared with currently available prognostic tools with favourable results.

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Yuen, Po-wing. "The study of nodal metastasis of oral tongue carcinoma." Click to view the E-thesis via HKUTO, 2008. http://sunzi.lib.hku.hk/hkuto/record/B39793837.

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Yuen, Po-wing, and 袁寶榮. "The study of nodal metastasis of oral tongue carcinoma." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2008. http://hub.hku.hk/bib/B39793837.

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Chawla, Rakhee. "The role of vascular endothelial growth factor in the nodal metastasis of malignant melanoma." Thesis, University of Liverpool, 2015. http://livrepository.liverpool.ac.uk/2009779/.

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Introduction: Malignant Melanoma is the most lethal of the skin cancers and the UK incidence is rising faster than that of any other cancer. Breslow thickness remains the best predictor of metastasis and Sentinel Lymph Node Biopsy is the only method of detecting nodal spread in clinically node negative patients. Surgery is the only effective therapy. Angiogenesis – the growth of new vessels from pre-existing vasculature - is an absolute requirement for tumour survival and progression beyond a few hundred microns in diameter. Anti- angiogenic isoforms of VEGF have been demonstrated previously to be protective with regard to metastasis. The aims of this thesis were to determine whether VEGF expression within the tumour may allow prediction of the nodal status. Furthermore another aim was to determine whether via the “Seed and Soil” theory, by examination of angiogenic and lymphangiogenic profiles of the tumour and node can we determine that the tumour may control the microenvironment around the Sentinel Node? Finally, as a cohort of false negative patients emerged with a higher mortality rate than their true negative and true positive patient cohort counterparts, could any further patterns be established by performing the same experiments on these patients? Methods: Archived human tumour and corresponding Sentinel Node samples were used and immunohistochemistry was used to investigate the role of pro and anti angiogenic isoforms of VEGF, VEGF-C, LYVE-1 and CD31 within these patients. Results: VEGF-C expression was significantly increased in the intranodal component of positive Sentinel Lymph Nodes (p < 0.01 Bonferroni). This increased expression appeared to be independent of tumoural influences and no strong evidence for the “Seed and Soil” theory was proved. A significantly higher number of lymphatic vessel counts were identified within node negative patients (p < 0.05 ANOVA). No further significant findings were defined on examination of the false negative cohort of patients. Conclusions: This study has shown that positive Sentinel Lymph Nodes exhibit high levels of intranodal VEGF-C. This expression does not appear to be related to tumoural influences. It would therefore appear that VEGF-C expression within Sentinel Nodes warrants further investigation and may aid diagnosis of spread or represent a target to slow or even prevent the onset of metastasis.

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Lee, Kai-chung Arthur, and 李啓聰. "The prognostic significance of lymphatic and blood vessel invasion, angiogenesis and occult nodal metastasis in breast carcinoma." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1995. http://hub.hku.hk/bib/B31981604.

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Lee, Kai-chung Arthur. "The prognostic significance of lymphatic and blood vessel invasion, angiogenesis and occult nodal metastasis in breast carcinoma." Click to view the E-thesis via HKUTO, 1995. http://sunzi.lib.hku.hk/hkuto/record/B31981604.

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Cappellesso, Rocco. "The value of histology, tumor infiltrating lymphocytes, and mismatch repair status as risk factors of nodal metastasis in screening detected and endoscopically removed pT1 colorectal cancers." Doctoral thesis, Università degli studi di Padova, 2018. http://hdl.handle.net/11577/3425398.

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BACKGROUND The number of patients with colorectal cancers (CRCs) invading the submucosa (pT1) resected during colonoscopy is increasing due to the screening. Such tumors are potentially metastatic, but only 15% of patients have nodal involvement. Histologic criteria currently used for selecting patients needing resection are imprecise and most patients are overtreated. Tumor infiltrating lymphocytes (TILs) and mismatch repair (MMR) status impact on CRC prognosis and could be risk factors of nodal metastasis. AIM To identify patients requiring completion surgery, the value of histologic variables, TILs, and MMR status as risk factors of nodal metastasis was investigated in screening detected and endoscopically removed pT1 CRCs. MATERIALS AND METHODS Histologic variables, CD3+ and CD8+ TILs, and MMR status were assessed in 102 endoscopically removed pT1 CRC. Univariate and multivariate analyses were used to evaluate the correlation with nodal metastasis. RESULTS Positive resection margin, evidence of vascular invasion and tumor budding, wide area of submucosal invasion, and high number of CD3+ TILs were associated with nodal metastasis in univariate analyses. Vascular invasion was statistically independent in multivariate analysis. Evidence of neoplastic cells in the vessels and/or at the excision border featured 5 out of 5 metastatic tumors and 13 out of 97 non-metastatic ones. CONCUSIONS Completion surgery should be mandatory only for patients with pT1 CRC with vascular invasion or with tumor cells reaching the margin. In all other cases, the treatment choice should be entrusted to the evaluation of the risk-benefit ratio of each patient considering the rarity of nodal metastasis.
INTRODUZIONE Il numero di pazienti con cancro colo-rettale (CCR) infiltrante la sottomucosa (pT1) rimosso durante colonscopia è in aumento per via dello screening. Tale tumore potenzialmente è già metastatico, ma solo un 15% di pazienti ha coinvolgimento linfonodale. I criteri istologi attualmente utilizzati per selezionare i pazienti che necessitino di una resezione di completamento sono imprecisi e la maggior parte dei pazienti subisce un trattamento eccessivo. I linfociti intra-tumorali (TILs) e lo stato del mismatch repair (MMR) condizionano la prognosi del CRC e potrebbero essere fattori di rischio di metastasi linfonodale. OBIETTIVO Per identificare i pazienti che necessitano di chirurgia di completamento, è stato valutato nei CRC pT1 identificati dallo screening e rimossi endoscopicamente il valore delle variabili istologiche, dei TILS e dello stato del MMR come fattori di rischio di metastasi linfonodale. MATERIALI E METODI Le variabili istologiche, i TILS CD3+ e CD8+ e lo stato del MMR sono stati valutati in 102 CRC pT1 rimossi endoscopicamente. Analisi univariate e multivariate sono state utilizzate per valutare la correlazione con la metastasi lindonodale. RISULTATI Il margine di resezione positive, la presenza di invasione vascolare e di budding tumorale, l'ampia area di invasione e l'elevato numero di TILs CD3+ erano associata alla metastasi linfonodale nelle analisi univariate. L'invasione vascolare era l'unica variabili indipendente all'analisi multivariata. La presenza di cellule neoplastiche intravascolari e/o a livello del margine di resezione caratterizzavano tutti e 5 i tumori metastatici e solo 13 tumori non metastatici su 97. CONCUSIONI La chirurgia di completamento dovrebbe essere indicata solo per i pazienti con un CRC pT1 con invasione vascolare o con cellule neoplastiche che raggiungono il margine di resezione. In tutti gli altri casi, la scelta del trattamento dovrebbe essere affidata alla valutazione del rapporto rischi-benefici di ciascun paziente tenendo in considerazione la raritÃ del coinvolgimento linfonodale.

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Books on the topic "Nodal metastase"

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International, Symposium on Cellular Oncology (2nd 1985 Palm Springs Calif ). Occult nodal metastasis in solid carcinomata. New York: Praeger, 1987.

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(Editor), Moloy, and Ph.D Garth Nicolson (Editor), eds. Occult Nodal Metastasis in Solid Carcinomata: Second International Symposium on Cellular Oncology (Cancer Research Monographs). Praeger Publishers, 1987.

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Book chapters on the topic "Nodal metastase"

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Veness, Michael, and Julie Howle. "Management of Nodal Metastases." In High-Risk Cutaneous Squamous Cell Carcinoma, 189–211. Berlin, Heidelberg: Springer Berlin Heidelberg, 2016. http://dx.doi.org/10.1007/978-3-662-47081-7_8.

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Rambaldi, Pier Francesco. "Nodal Metastases in Nasal Squamous Carcinoma." In Whole-Body FDG PET Imaging in Oncology, 45–47. Milano: Springer Milan, 2013. http://dx.doi.org/10.1007/978-88-470-5295-6_11.

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Rambaldi, Pier Francesco. "Esophageal Cancer and Secondary Nodal Metastases." In Whole-Body FDG PET Imaging in Oncology, 91–93. Milano: Springer Milan, 2013. http://dx.doi.org/10.1007/978-88-470-5295-6_22.

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Adeniran, Adebowale J., and David Chhieng. "Ectopic Thyroid Tissue Versus Nodal Metastasis." In Common Diagnostic Pitfalls in Thyroid Cytopathology, 299–307. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-31602-4_18.

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Gupta, Neeti Kapre, Ashok Shaha, Madan Laxman Kapre, Nirmala Thakkar, and Harsh Karan Gupta. "Management of Nodal Metastasis in Thyroid Cancer." In Thyroid Surgery, 113–17. First edition. | Boca Raton : CRC Press, 2020.: CRC Press, 2020. http://dx.doi.org/10.1201/9780429086076-15.

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Whigham, Amy S., and Wendell G. Yarbrough. "Prediction of Nodal Metastases from Genomic Analyses of the Primary Tumor." In Oral Cancer Metastasis, 75–103. New York, NY: Springer New York, 2009. http://dx.doi.org/10.1007/978-1-4419-0775-2_4.

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Haas, Judith Stitt, and James D. Cox. "Cervical Nodal Metastasis from an Unknown Primary Carcinoma." In Radiation Therapy of Head and Neck Cancer, 211–18. Berlin, Heidelberg: Springer Berlin Heidelberg, 1989. http://dx.doi.org/10.1007/978-3-642-83501-8_15.

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Potish, Roger A. "Radiotherapy in the management of nodal and peritoneal metastases." In Endometrial Cancer, 63–70. Boston, MA: Springer US, 1989. http://dx.doi.org/10.1007/978-1-4613-0867-6_5.

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Rambaldi, Pier Francesco. "Breast Carcinoma: Single Pulmonary and Multiple Lymph-nodal Metastases." In Whole-Body FDG PET Imaging in Oncology, 193–97. Milano: Springer Milan, 2013. http://dx.doi.org/10.1007/978-88-470-5295-6_44.

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Rambaldi, Pier Francesco. "Pulmonary Cancer with Numerous Nodal Hilar-Mediastinic and Bone Metastases." In Whole-Body FDG PET Imaging in Oncology, 289–92. Milano: Springer Milan, 2013. http://dx.doi.org/10.1007/978-88-470-5295-6_66.

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Conference papers on the topic "Nodal metastase"

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Dash, S., A. Goel, and S. Sogani. "Incremental Role of 18F-FDG PET with contrast enhanced CT (PET-CECT) in detection of recurrence of carcinoma cervix." In 16th Annual International Conference RGCON. Thieme Medical and Scientific Publishers Private Ltd., 2016. http://dx.doi.org/10.1055/s-0039-1685260.

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Purpose: To evaluate the role of 18F-FDG PET with contrast enhanced CT (PET-CECT) in early detection of recurrence in follow up patients of carcinoma cervix. Methods: Patients with histopathologically proven carcinoma cervix who underwent chemotherapy, radiotherapy and/or surgery and on follow up were recruited in the study. Fifty-two patients underwent 18F-FDG PET-CECT for detection of recurrence. The median age was 51.5 (average = 53.4) years. PET-CECT studies were evaluated and analyzed separately by an experienced nuclear medicine physician and a radiologist independently. The physicians were blinded for the patient history. PET-CECT results were validated with histopathological correlation, conventional radiologic imaging/follow up PET-CECT study and clinical follow up. Results: Out of 52 patients, 34 patients were reported as positive for recurrence, 17 of these were having active local recurrence and 31 patients had regional lymph nodal metastases, 14 patients had distant metastases (out of them 6 patients had distant lymph node metastases, 6 had pulmonary metastases, 4 had skeletal metastases and two had liver metastases). Remaining 18 patients were reported as negative for recurrence. The lung was the most common site for distant metastasis. Patient were then further evaluated based on histopathological correlation, conventional radiologic imaging and follow up PET-CECT scan and five were found to be false positive and one patient was identified as false negative. The sensitivity, specificity, positive and negative predictive value were derived to be 96.7%, 77.3%, 85.3% and 94.4%, respectively. Accuracy was calculated to be 88.5%. Conclusions: 18F-FDG PET-CECT is a very useful non-invasive modality for the early detection of recurrence and metastatic workup in patients with carcinoma cervix with a very high sensitivity and negative predictive value. It is also useful in targeting biopsy sites in suspected cases of recurrence.

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Elagwany, Ahmed. "2022-LBA-751-ESGO Nodal versus peritoneal metastasis on ultrasound." In ESGO 2022 Congress. BMJ Publishing Group Ltd, 2022. http://dx.doi.org/10.1136/ijgc-2022-esgo.1023.

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Andrearczyk, Vincent, Valentin Oreiller, Mario Jreige, Joel Castelli, John O. Prior, and Adrien Depeursinge. "Segmentation and Classification of Head and Neck Nodal Metastases and Primary Tumors in PET/CT." In 2022 44th Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC). IEEE, 2022. http://dx.doi.org/10.1109/embc48229.2022.9871907.

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Nobrega, L., R. Reis, C. Andrade, R. Schmidt, and M. Vieira. "415 CA-125 predicts nodal and distant metastases in preoperative Stage I low-risk endometrial cancer." In IGCS Annual 2019 Meeting Abstracts. BMJ Publishing Group Ltd, 2019. http://dx.doi.org/10.1136/ijgc-2019-igcs.415.

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Jaunarena, I., R. Ruiz, M. Gorostidi, J. Cespedes, D. Del Valle, P. Cobas, and A. Lekuona. "683 Incidence of nodal and isolated aortic metastases in patients with surgically staged endometrioid endometrial cancer." In ESGO 2021 Congress. BMJ Publishing Group Ltd, 2021. http://dx.doi.org/10.1136/ijgc-2021-esgo.180.

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Kim, EJ, BJ Chae, BJ Song, HY Kwak, EY Chang, SH Kim, and SS Jung. "Abstract P4-03-01: Distance of breast cancer from the skin influence axillary nodal metastasis." In Abstracts: Thirty-Fifth Annual CTRC‐AACR San Antonio Breast Cancer Symposium‐‐ Dec 4‐8, 2012; San Antonio, TX. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/0008-5472.sabcs12-p4-03-01.

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Gupta, Vivek, Amita Mishra, Namit Kalra, and Bhawna Narula. "A rare case report of incidental solitary uterine metastasis in primary invasive lobular carcinoma of breast." In 16th Annual International Conference RGCON. Thieme Medical and Scientific Publishers Private Ltd., 2016. http://dx.doi.org/10.1055/s-0039-1685401.

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Introduction: Infiltrating Lobular carcinoma (ILC) of the breast is second most common cancer of breast next only to Infiltrating ductal carcinoma (IDC). It has a different metastatic pattern as compared to the IDC. Breast cancer is the most frequent primary site which spreads to gynaecologic organs. Case Presentation: A 40 yrs old Iraqi lady presented as a diagnosed case of lobular carcinoma of left breast. She had already undergone a lumpectomy at Iraq a month back and now had come for completion of treatment. On metastatic workup with PETCT scan, we found a multicentric residual disease in the left breast along with some ipsilateral axillary LN with significant uptake. The concurrent CECT done showed a uterine leiomyomam also. As she was strongly hormone receptor positive, had completed her family and was having mennorhagia probably attributable to uterine fibroids. She was offered hysterectomy with B/L salpingo-oophorectomy. She was keen for breast preservation but in view of her multicentricity of disease on the left breast she was counselled for mastectomy with upfront whole breast reconstruction with TRAM flap. She underwent left modified radical mastectomy with hysterectomy with BSO and TRAM flap reconstruction. The histopathological examination revealed a multicentric, multifocal ILC, grade II with heavy nodal involvement including extracapsular extension. The leiomyoma of uterus also showed tumor deposits from lobular carcinoma breast. Conclusion: We report a very rare case of metastatic pattern of carcinoma of breast. On literature review we found that it is common for the lobular carcinomas of breast to metastasise to gynaecologic organs. Uterine corpus is a very rare site of metastasis for extragenital cancers including breast. All the patients of primary lobular carcinoma of breast should be screened for gynaecologic secondaries in the preoperative workup with high degree of suspicion.

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Verheuvel, Nicole C., Ingrid Van den Hoven, Hendrik WA Ooms, Vivianne CG Tjan-Heijnen, Rudi MH Roumen, and Adri C. Voogd. "Abstract P6-08-45: Predictive characteristics for extensive nodal involvement in patients with axillary lymph node metastases." In Thirty-Seventh Annual CTRC-AACR San Antonio Breast Cancer Symposium; December 9-13, 2014; San Antonio, TX. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.sabcs14-p6-08-45.

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Clausen, Martijn, Lieuwe J. Melchers, Leonie Bruine de Bruin, Mirjam F. Mastik, Lorian Slagter-Menkema, Harry J. Groen, Bert van der Vegt, et al. "Abstract 645: DNA methylation marker discovery for the prediction of nodal metastases in head and neck cancer." In Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1538-7445.am2013-645.

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Cruz, Marcelo Ribeiro da Luz, Valeria Fernandes Roppa Cruz, Alfredo Almeida Cunha, and Renato Souza Bravo. "CAN AXILLARY ULTRASONOGRAPHY WITH CORE NEEDLE BIOPSY BE A USEFUL TOOL IN THE APPROACH OF BREAST CANCER PATIENTS?" In Scientifc papers of XXIII Brazilian Breast Congress - 2021. Mastology, 2021. http://dx.doi.org/10.29289/259453942021v31s1004.

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Introduction: Metastatic involvement of axillary lymph nodes in patients with breast cancer is an important prognostic factor and it also has therapeutic implications. Nevertheless, the use of ultrasound for evaluating axillary lymph node status has been questioned. Objective: Evaluate the performance of ultrasound with core needle biopsy in the diagnosis of axillary metastasis. Patients and Method: A diagnostic validation study was performed to compare axillary ultrasound with core biopsy versus the surgical procedure. The scenario was a quaternary hospital in Rio de Janeiro where breast cancer patients were treated. The surgical procedure was the gold standard. Performance was assessed by calculating sensitivity, specificity, positive predictive value, negative predictive value, and estimated nodal disease burden. Result: Specificity and positive predictive values were 100% for the presence of axillary metastasis. The false negative rate was only 1.69% with a negative predictive value of 98.31% for the involvement of three or more lymph nodes. Conclusion: Axillary ultrasound with core needle biopsy shows excellent performance in assessing axillary metastatic impairment in patients with breast cancer, proving to be an effective tool in different clinical contexts.

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