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1

Millichap, J. Gordon. "Nocturnal Frontal Lobe Epilepsy." Pediatric Neurology Briefs 13, no. 6 (June 1, 1999): 47. http://dx.doi.org/10.15844/pedneurbriefs-13-6-10.

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2

Millichap, J. Gordon. "Nocturnal Frontal Lobe Epilepsy." Pediatric Neurology Briefs 10, no. 10 (October 1, 1996): 74. http://dx.doi.org/10.15844/pedneurbriefs-10-10-2.

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3

Ferini-Strambi, L. "Nocturnal frontal lobe epilepsy." Electroencephalography and Clinical Neurophysiology 103, no. 1 (July 1997): 61. http://dx.doi.org/10.1016/s0013-4694(97)88179-9.

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4

Ryvlin, Philippe, Sylvain Rheims, and Gail Risse. "Nocturnal Frontal Lobe Epilepsy." Epilepsia 47, s2 (November 2006): 83–86. http://dx.doi.org/10.1111/j.1528-1167.2006.00698.x.

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5

Millichap, J. Gordon. "Nocturnal Familial Frontal Lobe Epilepsy." Pediatric Neurology Briefs 12, no. 3 (March 1, 1998): 18. http://dx.doi.org/10.15844/pedneurbriefs-12-3-2.

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6

Oldani, Alessandro, Luigi Ferini-Strambi, and Marco Zucconi. "Symptomatic nocturnal frontal lobe epilepsy." Seizure 7, no. 4 (August 1998): 341–43. http://dx.doi.org/10.1016/s1059-1311(98)80030-7.

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7

Scheffer, Ingrid E., Kailash P. Bhatia, Iscia Lopes-Cendes, David R. Fish, C. David Marsden, Eva Andermann, Frederick Andermann, et al. "Autosomal dominant nocturnal frontal lobe epilepsy." Brain 118, no. 1 (February 1995): 61–73. http://dx.doi.org/10.1093/brain/118.1.61.

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8

Scheffer, Ingrid E. "Autosomal Dominant Nocturnal Frontal Lobe Epilepsy." Epilepsia 41, no. 8 (August 2000): 1059–60. http://dx.doi.org/10.1111/j.1528-1157.2000.tb00298.x.

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9

Derry, Christopher. "Nocturnal Frontal Lobe Epilepsy vs Parasomnias." Current Treatment Options in Neurology 14, no. 5 (August 5, 2012): 451–63. http://dx.doi.org/10.1007/s11940-012-0191-8.

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10

Bonanni, Paolo, Anna Volzone, Giovanna Randazzo, Lisa Antoniazzi, Angelica Rampazzo, Maurizio Scarpa, and Lino Nobili. "Nocturnal frontal lobe epilepsy in mucopolysaccharidosis." Brain and Development 36, no. 9 (October 2014): 826–29. http://dx.doi.org/10.1016/j.braindev.2013.12.002.

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11

Provini, F., G. Plazzi, and E. Lugaresi. "From nocturnal paroxysmal dystonia to nocturnal frontal lobe epilepsy." Clinical Neurophysiology 111 (September 2000): S2—S8. http://dx.doi.org/10.1016/s1388-2457(00)00396-5.

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12

Jiang, Yongning, and Xiangqin Zhou. "Frontal lobe epilepsy manifesting as vertigo: a case report and literature review." Journal of International Medical Research 48, no. 9 (September 2020): 030006052094616. http://dx.doi.org/10.1177/0300060520946166.

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Frontal lobe epilepsy is a common neurological disorder with a broad spectrum of symptoms. Frontal lobe epilepsy presenting with vertigo is extremely rare, and the relevant pathogenesis remains unclear. Herein, we report a case of frontal lobe epilepsy manifesting as vertigo, and we review the relevant literature. A 34-year-old woman presented with a 10-year history of general tonic–clonic seizures. In the month prior to admission, she experienced nocturnal seizures on two occasions. Video electroencephalogram monitoring showed frequent clinical seizures during which the patient felt transient vertigo. The ictal electroencephalogram revealed a medium-amplitude spike and slow wave complex originating from the frontal lobes. The patient was treated with oral sodium valproate, levetiracetam, and lamotrigine. After a 6-month follow-up period, her seizures were well controlled. Our findings expand the symptom spectrum of epilepsy, suggesting that vertigo can be an uncommon clinical manifestation of frontal lobe epilepsy. Although the pathological correlation between vertigo and epilepsy remains elusive, our findings indicate that vestibular cortical neurons may participate in periodic epileptiform discharges of the frontal lobe. Clinicians should be aware of a potential diagnosis of epilepsy in patients presenting with vertigo as the onset symptom because this condition is usually underdiagnosed.
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13

Patrikelis, Panayiotis, George Konstantakopoulos, Efthymios Angelakis, Elias Angelopoulos, Stylianos Gatzonis, and Damianos E. Sakas. "Passivity Phenomena in Nocturnal Frontal-Lobe Epilepsy." Journal of Neuropsychiatry and Clinical Neurosciences 23, no. 2 (January 2011): E26—E27. http://dx.doi.org/10.1176/jnp.23.2.jnpe26.

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14

Oldani, Alessandro, Mauro Manconi, Marco Zucconi, Cristina Martinelli, and Luigi Ferini-Strambi. "Topiramate treatment for nocturnal frontal lobe epilepsy." Seizure 15, no. 8 (December 2006): 649–52. http://dx.doi.org/10.1016/j.seizure.2006.07.002.

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15

Naldi, Ilaria, Francesca Bisulli, Luca Vignatelli, Laura Licchetta, Francesca Pittau, Lidia Di Vito, Barbara Mostacci, et al. "Tobacco habits in nocturnal frontal lobe epilepsy." Epilepsy & Behavior 26, no. 1 (January 2013): 114–17. http://dx.doi.org/10.1016/j.yebeh.2012.10.014.

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16

Tinuper, Paolo, Francesca Bisulli, Federica Provini, Pasquale Montagna, and Elio Lugaresi. "Nocturnal Frontal Lobe Epilepsy: New pathophysiological interpretations." Sleep Medicine 12 (December 2011): S39—S42. http://dx.doi.org/10.1016/j.sleep.2011.10.009.

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17

Varadkar, Sophia, John S. Duncan, and J. Helen Cross. "Acetazolamide and Autosomal Dominant Nocturnal Frontal Lobe Epilepsy." Epilepsia 44, no. 7 (June 19, 2003): 986–87. http://dx.doi.org/10.1046/j.1528-1157.2003.53002.x.

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18

Raju, G. Praveen, Dean P. Sarco, Annapurna Poduri, James J. Riviello, Ann Marie R. Bergin, and Masanori Takeoka. "Oxcarbazepine in Children With Nocturnal Frontal-Lobe Epilepsy." Pediatric Neurology 37, no. 5 (November 2007): 345–49. http://dx.doi.org/10.1016/j.pediatrneurol.2007.06.013.

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19

Oldani, Alessandro, Marco Zucconi, Salvatore Smirne, and Luigi Ferini-Strambi. "The neurophysiological evaluation of nocturnal frontal lobe epilepsy." Seizure 7, no. 4 (August 1998): 317–20. http://dx.doi.org/10.1016/s1059-1311(98)80025-3.

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20

Parrino, Liborio, Fernando De Paolis, Giulia Milioli, Gioia Gioi, Andrea Grassi, Silvia Riccardi, Elena Colizzi, and Mario Giovanni Terzano. "Distinctive polysomnographic traits in nocturnal frontal lobe epilepsy." Epilepsia 53, no. 7 (May 11, 2012): 1178–84. http://dx.doi.org/10.1111/j.1528-1167.2012.03502.x.

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21

Ferini-Strambi, Luigi, Veronica Sansoni, and Romina Combi. "Nocturnal Frontal Lobe Epilepsy and the Acetylcholine Receptor." Neurologist 18, no. 6 (November 2012): 343–49. http://dx.doi.org/10.1097/nrl.0b013e31826a99b8.

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22

Oldani, Alessandro, Marco Zucconi, Luigi Ferini-Strambi, Daniele Bizzozero, and Salvatore Smirne. "Autosomal Dominant Nocturnal Frontal Lobe Epilepsy: Electroclinical Picture." Epilepsia 37, no. 10 (October 1996): 964–76. http://dx.doi.org/10.1111/j.1528-1157.1996.tb00534.x.

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23

Cheng, JocelynY, MariaR Lopez, DouglasM Wallace, and EnriqueJ Carrazana. "Nocturnal frontal lobe epilepsy presenting as excessive daytime sleepiness." Journal of Family Medicine and Primary Care 2, no. 1 (2013): 101. http://dx.doi.org/10.4103/2249-4863.109969.

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24

Nobili, L., S. Francione, R. Mai, F. Cardinale, L. Castana, L. Tassi, I. Sartori, et al. "Surgical treatment of drug-resistant nocturnal frontal lobe epilepsy." Brain 130, no. 2 (February 1, 2007): 561–73. http://dx.doi.org/10.1093/brain/awl322.

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25

Provini, Federica, Giuseppe Plazzi, Pasquale Montagna, and Elio Lugaresi. "The wide clinical spectrum of nocturnal frontal lobe epilepsy." Sleep Medicine Reviews 4, no. 4 (August 2000): 375–86. http://dx.doi.org/10.1053/smrv.2000.0109.

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26

Oldani, A., M. Zucconi, C. Castronovo, and L. Ferini-Strambi. "Nocturnal frontal lobe epilepsy misdiagnosed as sleep apnea syndrome." Acta Neurologica Scandinavica 98, no. 1 (July 1998): 67–71. http://dx.doi.org/10.1111/j.1600-0404.1998.tb07381.x.

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27

Brodtkorb, Eylert, and Fabienne Picard. "Tobacco habits modulate autosomal dominant nocturnal frontal lobe epilepsy." Epilepsy & Behavior 9, no. 3 (November 2006): 515–20. http://dx.doi.org/10.1016/j.yebeh.2006.07.008.

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28

Mochi, M., F. Provini, G. Plazzi, R. Corsini, F. Farnedi, P. Tinuper, M. L. Valentino, E. Lugaresi, and P. Montagna. "Genetic heterogeneity in autosomal dominant nocturnal frontal lobe epilepsy." Italian Journal of Neurological Sciences 18, no. 3 (March 1997): 183. http://dx.doi.org/10.1007/bf02048489.

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29

Pisanu, P., F. Balconi, L. Tamburrino, M. G. Mascia, R. Lecca, G. Gioi, I. Laccu, P. Congiu, M. Figorilli, and M. Puligheddu. "Neurocognitive profile of patients with nocturnal frontal lobe epilepsy." Sleep Medicine 40 (December 2017): e262. http://dx.doi.org/10.1016/j.sleep.2017.11.767.

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30

Mody, Istvan. "Calcium and Autosomal Dominant Nocturnal Frontal Lobe Epilepsy (ADNFLE)." Epilepsy Currents 3, no. 6 (November 2003): 221–22. http://dx.doi.org/10.1046/j.1535-7597.2003.03603.x.

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31

Tung, Leon, and Gregory Carter. "1062 Differentiating confusional parasomnias from nocturnal frontal lobe epilepsy." Sleep 42, Supplement_1 (April 2019): A425—A426. http://dx.doi.org/10.1093/sleep/zsz069.1059.

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32

Provini, Federica, Pasquale Montagna, Giuseppe Plazzi, and Elio Lugaresi. "Nocturnal frontal lobe epilepsy: A wide spectrum of seizures." Movement Disorders 15, no. 6 (November 2000): 1264. http://dx.doi.org/10.1002/1531-8257(200011)15:6<1264::aid-mds1033>3.0.co;2-4.

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33

Rathore, Geetanjali, Paul Larsen, Manish Parakh, and Cristina Fernandez. "Choking at Night: A Case of Opercular Nocturnal Frontal Lobe Epilepsy." Case Reports in Pediatrics 2013 (2013): 1–3. http://dx.doi.org/10.1155/2013/606385.

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Frontal lobe seizures have a tendency to occur in sleep and in most cases occur exclusively insleep; these individuals are said to have nocturnal frontal lobe (NFLE). NFLE can be difficult to distinguish clinically from various other sleep disorders, particularly parasomnias, which also present with paroxysmal motor activity in sleep. Interictal and ictal EEG findings are frequently unremarkable or nonspecific in both parasomnias and NFLE making the diagnosis even more difficult. Nocturnal epilepsy should be suspected in patients with paroxysmal events at night characterized by high frequency, repetition, extrapyramidal features, and marked stereotypy of attacks. Here we present a 13-year-old female who was extensively worked up for choking episodes at night. On repeat video EEG she was found to have frontal opercular seizures. Once on Carbamazepine, her seizures completely resolved.
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34

Halász, Péter, Anna Kelemen, and Anna Szűcs. "Physiopathogenetic Interrelationship between Nocturnal Frontal Lobe Epilepsy and NREM Arousal Parasomnias." Epilepsy Research and Treatment 2012 (May 10, 2012): 1–8. http://dx.doi.org/10.1155/2012/312693.

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Aims. To build up a coherent shared pathophysiology of NFLE and AP and discuss the underlying functional network. Methods. Reviewing relevant published data we point out common features in semiology of events, relations to macro- and microstructural dynamism of NREM sleep, to cholinergic arousal mechanism and genetic aspects. Results. We propose that pathological arousals accompanied by confused behavior with autonomic signs and/or hypermotor automatisms are expressions of the frontal cholinergic arousal function of different degree, during the condition of depressed cognition by frontodorsal functional loss in NREM sleep. This may happen either if the frontal cortical Ach receptors are mutated in ADNFLE (and probably also in genetically not proved nonlesional cases as well), or without epileptic disorder, in AP, assuming gain in receptor functions in both conditions. This hypothesis incorporates the previous “liberation theory” of Tassinari and the “state dissociation hypothesis” of Bassetti and Terzaghi). We propose that NFLE and IGE represent epileptic disorders of the two antagonistic twin systems in the frontal lobe. NFLE is the epileptic facilitation of the ergotropic frontal arousal system whereas absence epilepsy is the epileptic facilitation of burst-firing working mode of the spindle and delta producing frontal thalamocortical throphotropic sleep system. Significance. The proposed physiopathogenesis conceptualize epilepsies in physiologically meaningful networks.
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35

Romigi, Andrea, Maria G. Marciani, Fabio Placidi, Laura R. Pisani, Francesca Izzi, Federico Torelli, and Chiara Prosperetti. "Oxcarbazepine in Nocturnal Frontal-Lobe Epilepsy: A Further Interesting Report." Pediatric Neurology 39, no. 4 (October 2008): 298. http://dx.doi.org/10.1016/j.pediatrneurol.2008.07.015.

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36

Halász, Peter, and Anna Kelemen. "Precipitatory role of arousal/antiarousal in nocturnal frontal lobe epilepsy." Clinical Neurophysiology 120, no. 3 (March 2009): 643. http://dx.doi.org/10.1016/j.clinph.2008.12.039.

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37

Cho, Jae Wook, Dae Jin Kim, Kyung Ha Noh, Seonhye Kim, Jae Hyeok Lee, and Jee Hyun Kim. "Nocturnal Frontal Lobe Epilepsy Presenting as Obstructive Type Sleep Apnea." Journal of Epilepsy Research 1, no. 2 (December 30, 2011): 74–76. http://dx.doi.org/10.14581/jer.11014.

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38

Kobayashi, Kenichiro, Maatoshi Ito, Tatsuya Fujii, Tomoko Miyajima, and Takehiko Okuno. "Autosomal Dominant Nocturnal Frontal Lobe Epilepsy in a Japanese Family." Epilepsia 41, s9 (September 2000): 57. http://dx.doi.org/10.1111/j.1528-1157.2000.tb02239.x.

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39

Terzaghi, Michele, Ivana Sartori, Roberto Mai, Laura Tassi, Stefano Francione, Francesco Cardinale, Laura Castana, et al. "Sleep-related Minor Motor Events in Nocturnal Frontal Lobe Epilepsy." Epilepsia 48, no. 2 (February 2007): 335–41. http://dx.doi.org/10.1111/j.1528-1167.2006.00929.x.

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40

Phillips, H. A., C. Marini, I. E. Scheffer, G. R. Sutherland, J. C. Mulley, and S. F. Berkovic. "A de novo mutation in sporadic nocturnal frontal lobe epilepsy." Annals of Neurology 48, no. 2 (August 2000): 264–67. http://dx.doi.org/10.1002/1531-8249(200008)48:2<264::aid-ana20>3.0.co;2-b.

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41

Miyajima, Tomoko, Tomohiro Kumada, Keiko Saito, and Tatsuya Fujii. "Autism in siblings with autosomal dominant nocturnal frontal lobe epilepsy." Brain and Development 35, no. 2 (February 2013): 155–57. http://dx.doi.org/10.1016/j.braindev.2012.07.012.

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42

Meierkord, H., D. R. Fish, S. J. M. Smith, C. A. Scott, S. D. Shorvon, and C. D. Marsden. "Is nocturnal paroxysmal dystonia a form of frontal lobe epilepsy?" Movement Disorders 7, no. 1 (1992): 38–42. http://dx.doi.org/10.1002/mds.870070107.

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43

Hildebrand, Michael S., Rick Tankard, Elena V. Gazina, John A. Damiano, Kate M. Lawrence, Hans‐Henrik M. Dahl, Brigid M. Regan, et al. "PRIMA1 mutation: a new cause of nocturnal frontal lobe epilepsy." Annals of Clinical and Translational Neurology 2, no. 8 (July 3, 2015): 821–30. http://dx.doi.org/10.1002/acn3.224.

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44

Kanner, Andres M. "Nocturnal Frontal Lobe Epilepsy: There is Bad, Good, and Very Good News!" Epilepsy Currents 7, no. 5 (September 2007): 131–33. http://dx.doi.org/10.1111/j.1535-7511.2007.00200.x.

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Surgical Treatment of Drug-Resistant Nocturnal Frontal Lobe Epilepsy. Nobili L, Francione S, Mai R, Cardinale F, Castana L, Tassi L, Sartori I, Didato G, Citterio A, Colombo N, Galli C, Lo Russo G, Cossu M. Brain 2007;130(Pt 2):561–573. Of the cases with nocturnal frontal lobe epilepsy (NFLE) 30% are refractory to antiepileptic medication, with several patients suffering from the effects of both ongoing seizures and disrupted sleep. From a consecutive series of 522 patients operated on for drug-resistant focal epilepsy, 21 cases (4%), whose frontal lobe seizures occurred almost exclusively (>90%) during sleep, were selected. All patients underwent a comprehensive pre-surgical evaluation, which included history, interictal EEG, scalp video-EEG monitoring, high-resolution MRI and, when indicated, invasive recording by stereo-EEG (SEEG). There were 11 males and 10 females, whose mean age at seizure onset was 6.2 years, mean age at surgery was 24.7 years and seizure frequency ranged from <20/month to >300/month. Nine patients reported excessive daytime sleepiness (EDS). Prevalent ictal clinical signs were represented by asymmetric posturing (6 cases), hyperkinetic automatisms (10 cases), combined tonic posturing and hyperkinetic automatisms (4 cases) and mimetic automatisms (1 case). All patients reported some kind of subjective manifestations. Interictal and ictal EEG provided lateralizing or localizing information in most patients. MRI was unrevealing in 10 cases and it showed a focal anatomical abnormality in one frontal lobe in 11 cases. Eighteen patients underwent a SEEG evaluation to better define the epileptogenic zone (EZ). All patients received a microsurgical resection in one frontal lobe, tailored according to pre-surgical evaluations. Two patients were operated on twice owing to poor results after the first resection. Histology demonstrated a Taylor-type focal cortical dysplasia (FCD) in 16 patients and an architectural FCD in 4. In one case no histological change was found. After a post-operative follow-up of at least 12 months (mean 42.5 months) all the 16 patients with a Taylor's FCD were in Engel's Class Ia and the other 5 patients were in Engel's Classes II or III. After 6 months post-surgery EDS had disappeared in the 9 patients who presented this complaint pre-operatively. It is concluded that patients with drug-resistant, disabling sleep-related seizures of frontal lobe origin should be considered for resective surgery, which may provide excellent results both on seizures and on epilepsy-related sleep disturbances. An accurate pre-surgical evaluation, which often requires invasive EEG recording, is mandatory to define the EZ. Further investigation is needed to explain the possible causal relationships between FCD, particularly Taylor-type, and sleep-related seizures, as observed in this cohort of NFLE patients.
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45

Pisano, Fabio, Giuliana Sias, Alessandra Fanni, Barbara Cannas, António Dourado, Barbara Pisano, and Cesar A. Teixeira. "Convolutional Neural Network for Seizure Detection of Nocturnal Frontal Lobe Epilepsy." Complexity 2020 (March 31, 2020): 1–10. http://dx.doi.org/10.1155/2020/4825767.

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The Nocturnal Frontal Lobe Epilepsy (NFLE) is a form of epilepsy in which seizures occur predominantly during sleep. In other forms of epilepsy, the commonly used clinical approach mainly involves manual inspection of encephalography (EEG) signals, a laborious and time-consuming process which often requires the contribution of more than one experienced neurologist. In the last decades, numerous approaches to automate this detection have been proposed and, more recently, machine learning has shown very promising performance. In this paper, an original Convolutional Neural Network (CNN) architecture is proposed to develop patient-specific seizure detection models for three patients affected by NFLE. The performances, in terms of accuracy, sensitivity, and specificity, exceed by several percentage points those in the most recent literature. The capability of the patient-specific models has been also tested to compare the obtained seizure onset times with those provided by the neurologists, with encouraging results. Moreover, the same CNN architecture has been used to develop a cross-patient seizure detection system, resorting to the transfer-learning paradigm. Starting from a patient-specific model, few data from a new patient are enough to customize his model. This contribution aims to alleviate the task of neurologists, who may have a robust indication to corroborate their clinical conclusions.
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46

Alsaleem, Mahdi, Vivien Carrion, Arie Weinstock, and Praveen Chandrasekharan. "Infantile refractory seizures due to de novo KCNT 1 mutation." BMJ Case Reports 12, no. 10 (October 2019): e231178. http://dx.doi.org/10.1136/bcr-2019-231178.

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We describe a term female infant who presented with multiple seizures early in infancy. The clinical and electrical seizures were refractory to traditional antiepileptic medications. After extensive workup, seizure panel testing revealed KCNT1 gene mutation, which is associated with nocturnal frontal lobe epilepsy and epilepsy of infancy with migrating focal seizures. The infant’s condition improved with the combination of traditional as well non-traditional antiepileptic therapy.
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47

Ferini-Strambi, L., M. Bozzali, M. Cercignani, A. Oldani, M. Zucconi, and M. Filippi. "Magnetization transfer and diffusion-weighted imaging in nocturnal frontal lobe epilepsy." Neurology 54, no. 12 (June 27, 2000): 2331–33. http://dx.doi.org/10.1212/wnl.54.12.2331.

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48

Tomonoh, Yuko, Sawa Yasumoto, Yukiko Ihara, Takako Fujita, Noriko Nakamura, Shinya Ninomiya, Rie Kodama, et al. "Diagnosing nocturnal frontal lobe epilepsy: A case study of two children." Seizure 20, no. 7 (September 2011): 583–85. http://dx.doi.org/10.1016/j.seizure.2011.03.004.

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49

Cox, Fieke M. E., Gert Jan Lammers, Roland D. Thijs, and Gerhard H. Visser. "Pearls & Oy-sters: Diagnostic challenges in nocturnal frontal lobe epilepsy." Neurology 86, no. 14 (April 4, 2016): e151-e153. http://dx.doi.org/10.1212/wnl.0000000000002539.

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50

Zucconi, Marco, and Luigi Ferini-Strambi. "NREM parasomnias: arousal disorders and differentiation from nocturnal frontal lobe epilepsy." Clinical Neurophysiology 111 (September 2000): S129—S135. http://dx.doi.org/10.1016/s1388-2457(00)00413-2.

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