Academic literature on the topic 'Noble Metal Nanoparticle - Biomedical Applications'
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Journal articles on the topic "Noble Metal Nanoparticle - Biomedical Applications"
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Sanchez, Laura M., and Vera A. Alvarez. "Advances in Magnetic Noble Metal/Iron-Based Oxide Hybrid Nanoparticles as Biomedical Devices." Bioengineering 6, no. 3 (August 28, 2019): 75. http://dx.doi.org/10.3390/bioengineering6030075.
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The study of the noble metal magnetic hybrid nanoparticles is a really promising topic from both the scientific and the technological points of views, with applications in several fields. Iron oxide materials which are hybridized with noble metal nanoparticles (NPs) have attracted increasing interest among researchers because of their cooperative effects on combined magnetic, electronic, photonic, and catalytic activities. This review article contains a summary of magnetic noble metal/iron oxide nanoparticle systems potentially useful in practical biomedical applications. Among the applications, engineered devices for both medical diagnosis and treatments were considered. The preparation to produce different structures, as blends or core-shell structures, of several nanometric systems was also considered. Several characterization techniques available to describe the structure, morphology and different kinds of properties of hybrid nanoparticles are also included in this review.
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Conde, João, Gonçalo Doria, and Pedro Baptista. "Noble Metal Nanoparticles Applications in Cancer." Journal of Drug Delivery 2012 (October 5, 2012): 1–12. http://dx.doi.org/10.1155/2012/751075.
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Nanotechnology has prompted new and improved materials for biomedical applications with particular emphasis in therapy and diagnostics. Special interest has been directed at providing enhanced molecular therapeutics for cancer, where conventional approaches do not effectively differentiate between cancerous and normal cells; that is, they lack specificity. This normally causes systemic toxicity and severe and adverse side effects with concomitant loss of quality of life. Because of their small size, nanoparticles can readily interact with biomolecules both at surface and inside cells, yielding better signals and target specificity for diagnostics and therapeutics. This way, a variety of nanoparticles with the possibility of diversified modification with biomolecules have been investigated for biomedical applications including their use in highly sensitive imaging assays, thermal ablation, and radiotherapy enhancement as well as drug and gene delivery and silencing. Here, we review the available noble metal nanoparticles for cancer therapy, with particular focus on those already being translated into clinical settings.
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Azharuddin, Mohammad, Geyunjian H. Zhu, Debapratim Das, Erdogan Ozgur, Lokman Uzun, Anthony P. F. Turner, and Hirak K. Patra. "A repertoire of biomedical applications of noble metal nanoparticles." Chemical Communications 55, no. 49 (2019): 6964–96. http://dx.doi.org/10.1039/c9cc01741k.
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The emerging properties of noble metal nanoparticles are attracting huge interest from the translational scientific community. In this feature article, we highlight recent advances in the adaptation of noble metal nanomaterials and their biomedical applications in therapeutics, diagnostics and sensing.
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Pandey, Prem C., and Govind Pandey. "Synthesis and characterization of bimetallic noble metal nanoparticles for biomedical applications." MRS Advances 1, no. 11 (2016): 681–91. http://dx.doi.org/10.1557/adv.2016.47.
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ABSTRACTWe report herein a facile approach to synthesize processable bimetallic nanoparticles (Pd-Au/AuPd/Ag-Au/Au-Ag) decorated Prussian blue nanocomposite (PB-AgNP). The presence of cyclohexanone/formaldehyde facilitates the formation of functional bimetallic nanoparticles from 3-aminopropyltrimethoxysilane (3-APTMS) capped desired ratio of hetero noble metal ions. The use of 3-APTMS and cyclohexanone also enables the synthesis of polycrystalline Prussian blue nanoparticles (PBNPs). As synthesized PBNPs, Pd-Au/Au-Pd/Ag-Au/Au-Ag enable the formation of nano-structured composites displaying better catalytic activity than that recorded with natural enzyme. The nanomaterials have been characterized by Uv-Vis, FT-IR and Transmission Electron Microscopy (TEM) with following major findings: (1) 3-APTMS capped noble metal ions in the presence of suitable organic reducing agents i.e.; 3 glycidoxypropyltrimethoxysilane (GPTMS), cyclohexanone and formaldehyde; are converted into respective nanoparticles under ambient conditions, (2) the time course of synthesis and dispersibility of the nanoparticles are found as a function of organic reducing agents, (3) the use of formaldehyde and cyclohexanone in place of GPTMS with 3-APTMS outclasses the other two in imparting better stability of amphiphilic nanoparticles with reduced silanol content, (4) simultaneous synthesis of bimetallic nanoparticles under desired ratio of palladium/gold and silver/ gold cations are recorded, (5) the nanoparticles made from the use of 3-APTMS and cyclohexanone enable the formation of homogeneous nanocomposite with PBNP as peroxidase mimetic representing potential substitute of peroxidase enzyme. The peroxidase mimetic ability has been found to vary as a function of 3-APTMS concentration revealing the potential role of functional metal nanoparticles in bioanalytical applications.
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Xu, Jing, Chuanqi Peng, Mengxiao Yu, and Jie Zheng. "Renal clearable noble metal nanoparticles: photoluminescence, elimination, and biomedical applications." Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology 9, no. 5 (January 10, 2017): e1453. http://dx.doi.org/10.1002/wnan.1453.
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Dehghan Banadaki, Arash, and Amir Kajbafvala. "Recent Advances in Facile Synthesis of Bimetallic Nanostructures: An Overview." Journal of Nanomaterials 2014 (2014): 1–28. http://dx.doi.org/10.1155/2014/985948.
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Nobel metal nanomaterials with interesting physical and chemical properties are ideal building blocks for engineering and tailoring nanoscale structures for specific technological applications. Bimetallic nanomaterials consisting of magnetic metals and noble metals have attracted much interest for their promising potentials in many fields including magnetic sensors, catalysts, optical detection, and biomedical applications. Particularly, effective control of the size, shape, architecture, and compositional microstructure of metal nanomaterials plays an important role in enhancing their functionality and application potentials, for example, in fuel cells, optical and biomedical sensing. This paper focuses on recent advances in controllable synthesis of bimetallic nanostructured materials. Recent contributions in controllable synthesis of bimetallic nanomaterials with different architectures including nanoparticles, nanowires, nanosheets, or nanotubes and their assemblies are presented in this paper. A wide range of facile synthesis methods are covered herein with high emphasis on wet chemical methods owing to their facility of use, efficacy, and smaller environmental footprint.
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Fernandez, Carlos A., and Chien W. Wai. "A Simple and Rapid Method of Making 2D and 3D Arrays of Gold Nanoparticles." Journal of Nanoscience and Nanotechnology 6, no. 3 (March 1, 2006): 669–74. http://dx.doi.org/10.1166/jnn.2006.120.
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Monodispersive gold nanoparticles can be synthesized by a dropwise addition of a reducing agent microemulsion to a gold ion microemulsion followed by immediate stabilization with 1-decanethiol. No size-selective precipitations or digestive ripening procedures are necessary. There is no need for metal functionalization of the surfactant AOT. Gold nanoparticles with an average size of 3.8 nm and a relative size dispersion of 5.4% were observed using n-heptane as a solvent. It seems possible to adjust the nanoparticle size by small changes in the carbon chain length of the solvent. Self-assembled 2D and 3D arrays of gold nanoparticles with adjustable sizes have been obtained on carbon-coated copper grids and on a silicon wafer. The arrays have good crystallinity as evidenced by the external morphology and transmission electron diffraction results. The size of the gold nanoparticle 3D arrays depends on the immersion time and can be greater than 15 μm. This approach could be used to synthesize other noble metal nanoparticle arrays that may lead to new materials for electronic and photonic applications.
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Saivarshine S, Keerthi Sasanka L, Gayathri R, and Dhanraj Ganapathy. "Awareness of Silver Nanoparticles and its Biomedical Applications among Undergraduate Dental and Medical Students - A Survey." International Journal of Research in Pharmaceutical Sciences 11, SPL3 (September 9, 2020): 140–44. http://dx.doi.org/10.26452/ijrps.v11ispl3.2904.
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Silver, which is considered as a noble metal, can be synthesised into nanoparticles which can be widely used in biomedical applications questionnaire was prepared and administered to 100 participants through Google forms - an online survey platform. The study population included all the undergraduate dental and medical students. The results were collected, and data were generated using SPSS software students (undergraduates) in the field of dentistry and medicine on a maximum amount were aware of that widespread biomedical applications of silver nanoparticles. The survey analysed the awareness of Silver nanoparticles and their biomedical applications among undergraduate medical and dental students.
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Tran, Hung-Vu, Nhat M. Ngo, Riddhiman Medhi, Pannaree Srinoi, Tingting Liu, Supparesk Rittikulsittichai, and T. Randall Lee. "Multifunctional Iron Oxide Magnetic Nanoparticles for Biomedical Applications: A Review." Materials 15, no. 2 (January 10, 2022): 503. http://dx.doi.org/10.3390/ma15020503.
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Due to their good magnetic properties, excellent biocompatibility, and low price, magnetic iron oxide nanoparticles (IONPs) are the most commonly used magnetic nanomaterials and have been extensively explored in biomedical applications. Although magnetic IONPs can be used for a variety of applications in biomedicine, most practical applications require IONP-based platforms that can perform several tasks in parallel. Thus, appropriate engineering and integration of magnetic IONPs with different classes of organic and inorganic materials can produce multifunctional nanoplatforms that can perform several functions simultaneously, allowing their application in a broad spectrum of biomedical fields. This review article summarizes the fabrication of current composite nanoplatforms based on integration of magnetic IONPs with organic dyes, biomolecules (e.g., lipids, DNAs, aptamers, and antibodies), quantum dots, noble metal NPs, and stimuli-responsive polymers. We also highlight the recent technological advances achieved from such integrated multifunctional platforms and their potential use in biomedical applications, including dual-mode imaging for biomolecule detection, targeted drug delivery, photodynamic therapy, chemotherapy, and magnetic hyperthermia therapy.
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Yang, Xu, Wu, Fang, Zhong, Wang, Bu, and Yuan. "Atomic Force Microscope Guided SERS Spectra Observation for Au@Ag-4MBA@PVP Plasmonic Nanoparticles." Molecules 24, no. 20 (October 21, 2019): 3789. http://dx.doi.org/10.3390/molecules24203789.
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Recently polymer encapsulated surface-enhanced-Raman-scattering (SERS) probes with internal noble metal core–shell structure has found growing applications in biomedical applications. Here we studied the SERS spectra of Au@Ag–4MBA@PVP (4MBA: 4-mercaptobenzoic acid; PVP: polyvinylpyrrolidone) plasmonic nanoparticles produced from a chemical reduction method. By linking the atomic force microscope (AFM) with the homebuilt confocal Raman spectrometer thus to use AFM images as guidance, we realized the measurement of the SERS spectra from separated nanoparticles. We investigated the cases for single nanoparticles and for dimer structures and report several observed results including SERS spectra linearly scaled with laser power, abrupt boosting and abnormal shape changing of SERS spectra for dimer structures. Based on the finite element method simulation, we explained the observed ratio of SERS signals between the dimer structure and the single nanoparticle, and attributed the observed abnormal spectra to the photothermal effect of these plasmonic nanoparticles. Our study provides valuable guidance for choosing appropriate laser power when applying similar SERS probes to image biological cells.
Dissertations / Theses on the topic "Noble Metal Nanoparticle - Biomedical Applications"
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Choi, Sungmoon. "Fluorescent noble metal nanodots for biological applications." Diss., Georgia Institute of Technology, 2010. http://hdl.handle.net/1853/37195.
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Commercial organic dyes are widely used for cellular staining due to their small size, high brightness, and chemical functionality. However, their blinking and photobleaching are not ideal for studying dynamics inside live cells. An improvement over organics and much larger quantum dots, silver nanodots (Ag NDs) exhibit low cytotoxicity and excellent brightness and photostability, while retaining small size. We have utilized ssDNA hairpin structures to encapsulate Ag NDs with excellent spectral purity, high concentration, and good chemical and photophysical stability in a variety of biological media. Multi-color staining of fixed and live cells has been achieved, suggesting the promise of Ag NDs as good fluorophores for intracellular imaging. The great brightness and photostability of Ag nanodots indicate that they might be outstanding imaging agents for in vivo studies when encapsulated in delivery vehicles. In addition, Ag NDs can be optically modulated, resulting in increased sensitivity within high backgrounds. These good characteristics are combined with delivery vehicles such as PLGA and nanogels. After encapsulation, Ag nanodots still retain their good photophysical properties and modulation. It might be useful for in vivo applications in the near future
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Roth, Kristina L. "Development of Metal-based Nanomaterials for Biomedical Applications." Diss., Virginia Tech, 2017. http://hdl.handle.net/10919/85365.
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New synthetic advances in the control of nanoparticle size and shape along with the development of new surface modifications facilitates the growing use of nanomaterials in biomedical applications. Of particular interest are functional and biocompatible nanomaterials for sensing, imaging, and drug delivery. The goal of this research is to tailor the function of nanomaterials for biomedical applications by improving the biocompatibility of the systems.
Our work demonstrates both a bottom up and a post synthetic approach for incorporating stability, stealth, and biocompatibility to metal based nanoparticle systems. Two main nanomaterial projects are the focus of this dissertation. We first investigated the development of a green synthetic procedure to produce gold nanoparticles for biological imaging and sensing. The size and morphology of gold nanoparticles directly impact their optical properties, which are important for their function as imaging agents or their use in sensor systems. In this project, a synthetic route based on the natural process of biomineralization was developed, where a designed protein scaffold initiates the nucleation and subsequent growth of gold ions. To gain insight into controlling the size and morphology of the synthesized nanoparticles, interactions between the gold ions and the protein surface were studied along with the effect of ionic strength on interactions and then subsequent crystal growth. We are able to control the size and morphology of the gold nanoparticles by altering the concentration or identity of protein scaffold, salt, or reducing agent.
The second project involves the design and optimization of metal organic framework nanoparticles for an external stimulus triggered drug delivery system. This work demonstrates the advantages of using surface coatings for improved stability and functionalization. We show that the addition of a polyethylene glycol surface coating improved the colloidal stability and biocompatibility of the system. The nanoparticle was shown to successfully encapsulate a variety of small molecule cargo. This is the first report of photo-triggered degradation and subsequent release of the loaded cargo as a mechanism of stimuli-controlled drug delivery. Each of the aforementioned projects demonstrates the design, synthesis, and optimization of metal-based systems for use in biomedical applications.Ph. D.
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Vadala, Michael Lawrence. "Preparation and Functionalization of Macromolecule-Metal and Metal Oxide Nanocomplexes for Biomedical Applications." Diss., Virginia Tech, 2006. http://hdl.handle.net/10919/27098.
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Copolymer-cobalt complexes have been formed by thermolysis of dicobalt octacarbonyl in solutions of copolysiloxanes. The copolysiloxane-cobalt complexes formed from toluene solutions of PDMS-b-[PMVS-co-PMTMS] block copolymers were annealed at 600-700 °C under nitrogen to form protective siliceous shells around the nanoparticles. Magnetic measurements after aging for several months in both air and in water suggest that the ceramic coatings do protect the cobalt against oxidation. However, after mechanical grinding, oxidation occurs. The specific saturation magnetization of the siliceous-cobalt nanoparticles increased substantially as a function of annealing temperature, and they have high magnetic moments for particles of this size of 60 emu g-1 Co after heat-treatment at temperatures above 600 °C. The siliceous-cobalt nanoparticles can be re-functionalized with aminopropyltrimethoxysilane by condensing the coupling agent onto the nanoparticle surfaces in anhydrous, refluxing toluene. The concentration of primary amine obtained on the surfaces is in reasonable agreement with the charged concentrations. The surface amine groups can initiate L-lactide and the biodegradable polymer, poly(L-lactide), can be polymerized directly from the surface. The protected cobalt surface can also be re-functionalized with poly(dimethylsiloxane) and poly(ethylene oxide-co-propylene oxide) providing increased versatility for reacting polymers and functional groups onto the siliceous-cobalt nanoparticles.Phthalonitrile containing graft copolysiloxanes were synthesized and investigated as enhanced oxygen impermeable shell precursors for cobalt nanoparticles. The siloxane provided a silica precursor whereas the phthalonitrile provided a graphitic precursor. After pyrolysis, the surfaces were silicon rich and the complexes exhibited a substantial increase in Ms. Early aging data suggests that these complexes are oxidatively stable in air after mechanical grinding. Aqueous dispersions of macromolecule-magnetite complexes are desirable for biomedical applications. A series of vinylsilylpropanol initiators, where the vinyl groups vary from one to three, were prepared and utilized for the synthesis of heterobifunctional poly(ethylene oxide) oligomers with a free hydroxy group on one end and one to three vinylsilyl groups on the other end. The oligomers were further modified with carboxylic acids via ene-thiol addition reactions while preserving the hydroxyl functionality at the opposite terminus. The resulting carboxylic acid heterobifunctional PEO are currently being investigated as possible dispersion stabilizers for magnetite in aqueous media.Ph. D.
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AMICI, JULIA GINETTE NICOLE. "Preparation and characterization of metallic and metal oxide nanoparticles for biomedical applications." Doctoral thesis, Politecnico di Torino, 2013. http://hdl.handle.net/11583/2511697.
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Two of the 21st century most promising technologies are biotechnology and nanotechnology. This science of nanoscale structures deals with the creation, investigation and utilization of systems that are 1000 times smaller than the components currently used in the field of microelectronics. Convergence of these two technologies results in growth of nanobiotechnology. This interdisciplinary combination can create many innovative tools. The biomedical applications of nanotechnology are the direct products of such convergence.
Indeed, due to their unique size-dependent properties, nanomaterials have the potential to revolutionize the detection, diagnosis, and treatment of diseases by offering superior capabilities compared to conventionally used materials. Today nanomaterials have been designed for a variety of biomedical and biotechnological applications, including biosensors, enzyme encapsulation; neuronal nanotechnology, on the other hand, is based on the introduction of novel nanomaterials which can result in revolutionary new structures and devices using extremely biologically sophisticated tools to precisely position molecules. Nanotechnology in biomedical sciences presents many revolutionary opportunities in the fight against all kinds of cancer, cardiac and neurodegenerative disorders, infection and other diseases. Utility of nanotechnology to biomedical sciences imply creation of materials and devices designed to interact with the body at sub-cellular scales with a high degree of specificity. This could be potentially translated into targeted cellular and tissue-specific clinical applications aimed at maximal therapeutic effects with very limited adverse-effects.
Nanoparticles are part of the family of devices nanotechnology had given birth to. By their size and morphologic properties they encounter a large panel of different applications, biomedical applications are part of this panel. These specific nanoparticles can cover different functions from diagnosis to direct treatment; more specifically they can be used as carriers for specific delivery of drugs or as vector for specific therapies. In a first chapter different kind ofnanoparticles will be described in a first time, and the related therapy they apply to will be explained in a second time.
In order to be used for this specific kind of application, the nanoparticles should comply with a certain number of requirements and specifications. To this end, not only the materials used for their preparation, but also the method employed should satisfy such requirements. In a second chapter, the requirements will be listed and their implications will be explained, and in the third chapter specific preparation methods meeting these criteria will be described.
A lot of research is currently being conducted on this specific topic, for this reason it is a challenge to constantly find new methods of preparation and new materials meeting all the previously described requirements and in the same time bringing and improvement in the potential treatments.
In the fourth chapter will be described the materials and methods I used to prepare devices and take up that challenge.
Firstly, a new fast and convenient method is reported for preparing magnetic nanoparticles with a Fe3O4 core and a Poly(ethylene glycol)-diacrylate shell in water. A reduction coprecipitation method was used to obtain Fe3O4 in aqueous solution whereas the PEGDA coating was obtain via photochemical reaction at room temperature in an initiator free aqueous system. The fact that this method is solvent free and initiator free makes it ideal for biomedical applications.
Secondly, magnetite nanoparticles were coated following a previous surface functionalization. The Fe3O4 nanoparticles were obtained as before and further stabilized with citric acid. Afterwards nanoparticles surface was modified by a silanization reaction with vinyltrimethoxysilane involving magnetite hydroxyl groups. Vinyl functionalized nanoparticles were coated with poly (ethylene-glycol) (PEG) using PEG dithiol (PEG-SH) under UV irradiation. Thiol-ene is a free-radical reaction that proceeds by a step-growth mechanism, involving two main steps, a free-radical addition followed by a chain transfer reaction; this reaction is well known for occurring in absence of any radical photoinitiator making it ideal for eventual biomedical applications.
Thirdly, the use of ―click‖ reactions for preparing magnetic NPs with Fe3O4core and different biocompatible polymeric shells is reported. Magnetite nanoparticles were obtained following the same procedure that in the first two studies. As a next step, magnetic nanoparticles surface was modified by a silanization reaction with (3-bromopropyl)trimethoxysilane in order to introduce bromine groups on the particles surface. Afterwards the bromine groups were converted to azide groups by the reaction with sodium azide in order to obtain azide groups to take part to click reaction with alkyne functionalized polymers. For this reason, acetylene functionalized poly(ethylene glycol) (a-PEG) and poly(ε-caprolactone) (a-PCL) were synthesized and grafted onto the surface of azide functionalized nanoparticles via ―click‖ reaction to obtain monodisperse magnetic nanoparticles. The peculiar characteristics of this method make it ideal for biomedical applications.
Fourthly, a new, fast and convenient method for preparing gold nanoparticles with a poly(ethylene glycol)-diacrylate (PEGDA) shell in water is reported. Polyethyleneglycol (PEG) was used as hydrophilic monomer in emulsifier-free emulsion polymerization to form polymeric nanoparticles by the UV-induced process. At the same time, gold was generated as the core of the PEG nanospheres by the reduction of HAuCl4 activated through the radical photogenerated from 2-hydroxy-2-methyl-1-phenyl-1-propanone. This one-step procedure is very easy to implement and fast. Moreover, the fact that this method is performed in water makes it ideal for biomedical applications.
Fifthly, hollow gold nanoparticles were prepared and coated with Poly(ethylene glycol) methyl ether thiol. In a first time, cobalt nanoparticles were prepared by reduction of cobalt salts and in a second time gold salts were reduced on the surface of cobalt nanoparticles forming a gold shell while consuming the cobalt, leaving at the end of the reaction a hollow gold nanoparticles. Successively these devices were coated with the polymer taking advantage of the natural affinity between thiol groups and gold.
Sixthly, gold nanoshell were prepared and coated with Poly(ethylene glycol) methyl ether thiol. Gold nanoshells are constituted by a silica core and a gold shell. Silica nanoparticles were obtained by the well-known Stöber method, then gold seeds (3 nm diameter) were grafted on the surface of these silica nanoparticles and successively grown by gold salts addition until obtaining a continuous and homogeneous gold shell. In the end these devices were coated with the polymer taking advantage of the natural affinity between thiol groups and gold.
The fifth and sixth chapters describe the characterization of these devices correlated to their potential applications.
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Porret, Estelle. "Applications des nanoclusters de métaux nobles pour lediagnostic et la thérapie ciblée du cancer Hydrophobicity of Gold Nanoclusters Influences Their Interactions with Biological Barriers Metal nanoclusters for biomedical applications : toward in vivo studies." Thesis, Université Grenoble Alpes (ComUE), 2019. https://thares.univ-grenoble-alpes.fr/2019GREAV034.pdf.
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Les nanoparticules d’or (Au NPs) ont montré des résultats prometteurs en nanomédecine appliquée à la cancérologie. Elles sont capables de s’accumuler dans les zones tumorales, d’induire un effet thérapeutique en délivrant des principes actifs ou un effet photo/radiothérapeutique grâce à leurs propriétés d’absorption d’énergie. Elles permettent aussi le diagnostic par différentes techniques d’imagerie. Cette double activité les définit comme des agents théranostics. Les nanoclusters d’or (Au NCs) forment une sous-famille intéressante de Au NPs. Ils sont composés d’une dizaine à une centaine d’atomes d’or stabilisés par des molécules organiques. Leur taille inférieure à ~8 nm leur permet d’être éliminé par les reins et d’avoir des propriétés de photoluminescence (PL) jusque dans l’infrarouge, une fenêtre spectrale adaptée à l’imagerie optique in vivo. Ils peuvent aussi induire la mort cellulaire sous irradiation en raison des propriétés intrinsèques de l’or. Leurs propriétés optiques, de circulation sanguine et d’accumulation tumorale sont sensibles à de faibles modifications de la taille des Au NCs et de leur chimie de surface. Actuellement, les résultats précliniques sont encore insuffisants pour espérer un transfert en clinique et il est nécessaire d’améliorer la caractérisation des Au NCs et d’étudier leur comportement in vitro et in vivo.Dans ce contexte, mon projet de thèse a consisté à fonctionnaliser ces Au NCs pour améliorer leur accumulation tumorale. La première stratégie repose sur l’auto-agrégation des Au NCs dans le microenvironnement tumoral. Pour cela la surface des Au NCs a été soit i) fonctionnalisée avec des molécules chimiques favorisant des réactions de chimie click bioorthogonale, soit ii) fonctionnalisée avec des monobrins d’oligonucléotides complémentaires pouvant s’hybrider. L’auto-agrégation des Au NCs en solution a confirmée l’augmentation de la PL par transfert d’énergie inter-particules. Cette propriété pourrait éventuellement améliorer l’effet thérapeutique, mais ils doivent encore être caractérisés in vivo. La seconde stratégie a consisté à augmenter l’affinité des Au NCs pour les cellules en ajoutant de l’arginine à la surface des Au NCs de façon contrôlée. En effet, l’arginine est connue pour favoriser l’interaction électrostatique avec les membranes plasmiques et l’internalisation cellulaire. Nous avons déterminé le seuil maximum d’arginine par Au NCs permettant d’augmenter la PL tout en conservant leur petite taille. Les meilleurs candidats ont une forte capacité d’interaction électrostatique avec des membranes artificielles même en présence de sérum, suggérant que l’opsonisation des Au NCs est faible. Leurs capacités d’interaction (< 5min) et d’internalisation (<30 min) sont rapides et ont été confirmées sur des cellules humaines de mélanome in vitro, sans toxicité notable. Cependant d’après une étude sur des sphéroïdes irradiés, l’ajout d’arginines aurait un effet « de pirégeage » sur la production d’espèces réactives oxygénées diminuant le pouvoir radiosensibilisant des Au NCs. La présence de charges positives sur les Au NCs contenant des arginines et leur capacité d’internalisation permettent aussi de les utiliser in vitro pour vectoriser des polymères anioniques tels que des siRNA. En revanche, ces Au NCs administrés par voie intraveineuse chez des souris porteuses de tumeurs sont tous éliminés extrêmement rapidement par voie rénale ce qui ne leur permet pas de s’accumuler suffisamment dans les tumeurs. Ces travaux démontrent donc que la fonctionnalisation des Au NCs influence fortement leurs propriétés optiques et physico-chimiques, leurs interactions avec les cellules et leurs effets théranostics. Il serait intéressant d’appliquer ces stratégies sur des Au NCs circulants plus longtemps dans le sang pour démontrer l’effet de ces fonctionnalisations sur l’accumulation tumoraleGold nanoparticles (Au NPs) have shown promising results in nanomedicine applied to oncology. They are capable of accumulating in tumor areas, inducing a therapeutic effect by delivering drugs or a photo-/radiotherapeutic effect thanks to their energy absorption properties. They also allow diagnosis by different imaging techniques. This dual activity defines them as theranostic agents. Gold nanoclusters (Au NCs) define an interesting sub-family of Au NPs. They are composed of about ten to hundred gold atoms stabilized by organic molecules. Their size smaller than ~8 nm allows them to be eliminated by the kidneys and to exhibit photoluminescence (PL) properties until infrared wavelengths, which are suitable for in vivo optical imaging. They can also induce cell death under irradiation due to the intrinsic properties of gold. Their optical features, pharmaco-kinetic and tumor accumulation are highly sensitive to size and surface chemistry modification. Currently, preclinical results are not sufficient for clinical transfer and it is necessary to improve the characterization of Au NCs and to study their behaviour in vitro and in vivo.In this context, my thesis project focused on the functionalization of Au NCs in order to improve their accumulation in tumors. The first strategy is based on the self-aggregation of Au NCs in the tumor microenvironment. For this purpose, the surface of the Au NCs was either functionalized with i) molecules promoting bioorthogonal click chemistry reactions, or ii) complementary oligonucleotides that can hybridize. The self-aggregation of Au NCs in solution confirmed the increase in PL by inter-particle energy transfer. The self-agregation of Au NCs could potentially improve the therapeutic effect, but the Au NCs still need to be characterized in vivo. The second strategy consisted in increasing the affinity of Au NCs for cells by adding controlled amounts of arginine on their surface. Indeed, arginine is known to promote electrostatic interaction with plasma membranes and cellular internalization. We have determined the maximum arginine threshold per Au NCs, allowing to increase the PL while keeping their small size with high colloidal stability. The best candidates have a high capacity for electrostatic interaction with artificial membranes even in the presence of serum, suggesting that the opsonization of Au NCs is low. Their interaction (< 5min) and internalization (<30 min) capacities are rapid, and have been confirmed on human melanoma cells in vitro, without significant toxicity. However, according to a study on irradiated spheroids performed in our team, the addition of arginines would have a "trapping" effect on the production of reactive oxygen species, reducing the radiosensitizing power of Au NCs. The presence of positive charges on Au NCs containing arginines and their internalization capacity also can serve in vitro to deliver anionic polymers and biomolecules such as siRNA. However, these Au NCs administered intravenously to tumor-bearing mice are eliminated extremely rapidly by the kidneys, thus reducing their ability to accumulate in tumors. This work showed that the functionalization of Au NCs strongly influences their optical and physicochemical properties, their interactions with cells and their theranostic effects. It would be interesting to apply these strategies to Au NCs circulating longer in the blood to demonstrate the effect of these functionalizations on tumor diagnostics and therapy
Book chapters on the topic "Noble Metal Nanoparticle - Biomedical Applications"
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Sabui, Piyali, Sadhucharan Mallick, and Adhish Jaiswal. "Synthesis and Biomedical Application of Coinage-Metal Nanoparticle and Their Composite." In Synthesis and Applications of Nanomaterials and Nanocomposites, 147–70. Singapore: Springer Nature Singapore, 2023. http://dx.doi.org/10.1007/978-981-99-1350-3_6.
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Filipović, Nenad, Nina Tomić, Maja Kuzmanović, and Magdalena M. Stevanović. "Nanoparticles. Potential for Use to Prevent Infections." In Urinary Stents, 325–39. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-031-04484-7_26.
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AbstractOne of the major issues related to medical devices and especially urinary stents are infections caused by different strains of bacteria and fungi, mainly in light of the recent rise in microbial resistance to existing antibiotics. Lately, it has been shown that nanomaterials could be superior alternatives to conventional antibiotics. Generally, nanoparticles are used for many applications in the biomedical field primarily due to the ability to adjust and control their physicochemical properties as well as their great reactivity due to the large surface-to-volume ratio. This has led to the formation of a new research field called nanomedicine which can be defined as the use of nanotechnology and nanomaterials in diagnostics, imaging, observing, prevention, control, and treatment of diseases. For example, coverings or coatings based on nanomaterials are now seen as a promising strategy for preventing or treating biofilms formation on healthcare kits, implants, and medical devices. Toxicity, inappropriate delivery, or degradation of conventionally used drugs for the treatment of infections may be avoided by using nanoparticles without or with encapsulated/immobilized active substances. Most of the materials which are used and examined for the preparation of the nanoparticles with encapsulated/immobilized active substances or smart reactive nanomaterials with antimicrobial effects are polymers, naturally derived antimicrobials, metal-based and non-metallic materials. This chapter provides an overview of the current state and future perspectives of the nanoparticle-based systems based on these materials for prevention, control, or elimination of biofilm-related infections on urinary stents. It also addresses manufacturing conditions indicating the huge potential for the improvement of existing and development of new promising stent solutions.
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Zhang, Zhenjiang, and Ping-Chang Lin. "Noble metal nanoparticles: synthesis, and biomedical implementations." In Emerging Applications of Nanoparticles and Architecture Nanostructures, 177–233. Elsevier, 2018. http://dx.doi.org/10.1016/b978-0-323-51254-1.00007-5.
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Fabris, Laura. "Noble Metal Nanoparticles as SERS Tags: Fundamentals and Biomedical Applications." In The World Scientific Encyclopedia of Nanomedicine and Bioengineering I, 67–101. WORLD SCIENTIFIC, 2016. http://dx.doi.org/10.1142/9789813202504_0003.
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Marson, Domenico, Ye Yang, Stefan Guldin, and Paola Posocco. "Noble metal nanoparticles with anisotropy in shape and surface functionality for biomedical applications." In Anisotropic Particle Assemblies, 313–33. Elsevier, 2018. http://dx.doi.org/10.1016/b978-0-12-804069-0.00011-3.
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Nasrollahzadeh, Mahmoud, Nayyereh Sadat Soheili Bidgoli, Fahimeh Soleimani, Nasrin Shafiei, Zahra Nezafat, and Talat Baran. "Biomedical applications of biopolymer-based (nano)materials." In Biopolymer-Based Metal Nanoparticle Chemistry for Sustainable Applications, 189–332. Elsevier, 2021. http://dx.doi.org/10.1016/b978-0-323-89970-3.00005-6.
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Rivera, V. A. G., F. A. Ferri, and E. Marega. "Localized Surface Plasmon Resonances: Noble Metal Nanoparticle Interaction with Rare-Earth Ions." In Plasmonics - Principles and Applications. InTech, 2012. http://dx.doi.org/10.5772/50753.
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N. Moholkar, Disha, Darshana V. Havaldar, Rachana S. Potadar, and Kiran D. Pawar. "Optimization of Biogenic Synthesis of Colloidal Metal Nanoparticles." In Colloids - Types, Preparation and Applications [Working Title]. IntechOpen, 2020. http://dx.doi.org/10.5772/intechopen.94853.
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Nanotechnology which deals with the synthesis and characterization of dispersed or solid particles in nano-metric range has emerged out to be a novel approach due to its ample applications in biomedical fields. The advancements in the field of nanotechnology and substantial evidences in biomedical applications have led the researchers to explore safe, ecofriendly, rapid and sustainable approaches for the synthesis of colloidal metal nanoparticles. This chapter illustrates superiority of biogenic route of synthesis of nanoparticles over the different approaches such as chemical and physical methods. In biogenic route, plants and microorganisms like algae, fungi, yeast, actinomycetes etc. act as “bio-factories” which reduce the metal precursors and play a crucial role in the synthesis of nanoparticles with distinct morphologies. Thus, the need of hazardous chemicals is eliminated and a safer and greener approach of nanoparticles synthesis can be adopted. This chapter also outlines the effect of optimization of different parameters mainly pH, temperature, time and concentration of metal ions on the nanoparticle synthesis. It is evident that the optimization of various parameters can yield nanoparticles with desired properties suitable for respective biomedical applications.
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Alexis S.P. Tubalinal, Gabriel, Leonard Paulo G. Lucero, Jim Andreus V. Mangahas, Marvin A. Villanueva, and Claro N. Mingala. "Application of Noble Metals in the Advances in Animal Disease Diagnostics." In Noble Metals and Intermetallic Compounds - Recent Advanced Studies and Applications [Working Title]. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.99162.
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The advent of molecular biology and biotechnology has given ease and comfort for the screening and detection of different animal diseases caused by bacterial, viral, and fungal pathogens. Furthermore, detection of antibiotics and its residues has advanced in recent years. However, most of the process of animal disease diagnostics is still confined in the laboratory. The next step to conduct surveillance and prevent the spread of animal infectious diseases is to detect these diseases in the field. Through the discovery and continuous development in the field of nanobiotechnology, it was found that incorporation of noble metal nanoparticles to biotechnology tools such as the loop-mediated isothermal amplification (LAMP), lateral flow assays (LFAs) and dipsticks provided a promising start to conduct point-of-care diagnostics. Moreover, the modification and application of nanoparticle noble metals has increased the stability, effectiveness, sensitivity and overall efficacy of these diagnostic tools. Thus, recent advances in disease diagnostics used these noble metals such as gold, silver and platinum.
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Eddy, Nnabuk Okon, and Rajni Garg. "CaO Nanoparticles." In Handbook of Research on Green Synthesis and Applications of Nanomaterials, 247–68. IGI Global, 2022. http://dx.doi.org/10.4018/978-1-7998-8936-6.ch011.
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Adsorption is widely acknowledged as one of the best options that are available for the removal of contaminants from water. Contamination of water does not only create water scarcity, but it has the capacity to generate and transfer several environmental problems including threat to public health. This chapter reviewed calcium oxide nanoparticle (CaONP) as a noble metal oxide for the removal of contaminants from water. The review is concentrated in the general overview of water contamination, metal oxide nanoparticles, general application of CaONP, synthetic methods, characterization method, and applications. The chapter observed that little is done on the use of CaONP for the removal of contaminants from water except for dyes, some heavy metal ions, and few organic/inorganic compounds. It is also observed that CaONP can be applied as adsorbent and in photocatalytic degradation of dye. Suggestions are made on the possibility of utilizing local raw materials that are easily accessible, cheap, and environmental sources of raw materials for the synthesis of CaONP.
Conference papers on the topic "Noble Metal Nanoparticle - Biomedical Applications"
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Kulah, Jonathan, and Ahmet Aykaç. "Synthesis and Characterization of Graphene Quantum Dots Functionalized Silver Nanoparticle from Moringa Oleifera Extracts." In 6th International Students Science Congress. Izmir International Guest Student Association, 2022. http://dx.doi.org/10.52460/issc.2022.050.
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Graphene quantum dots (GQDs) are famously known for large surface area, good dispersibility, good conductivity, and high transparency with good photochemical, electrochemical, and optical properties that are utilized in many biomedical and biotechnological applications. Interestingly, GQDs were reported to serve as an excellent reducing reagent in the synthesis of noble metal nanoparticles such as silver nanoparticles (AgNPs). Moreover, GQDs eradicate the limitation of impurities of AgNPs synthesized using plant extracts as a stabilizer and reducing agents. Therefore, we experimented GQDs synthesis from moringa oleifera (MO) plant extracts compared to citric and urea synthesized GQDs. And used the synthesized GQDs to synthesize, reduce and functionalize AgNPs. MO contains about 110 compounds, high nutrients, vitamins, oleic oil, and phytoconstituents such as alkaloids, flavonoids, glucosinolates, saponins, tannins, terpenes, steroids, phenolic acids, which suggested to us that, MO extracts can serve as a capping agent in the synthesis of nanoparticles. Initially, MO leaves and seeds water phase extracts were obtained by overnight distillation and lyophilized to create a stock solution of 1mg/ml. Next, following Das, R. et al and slightly modifying the followed method by varying the MO extract concentration from 20µL to 60 µL, AgNPs were synthesized by hydrothermal method. GQDs were separately synthesized adopting Tran, H.V. et al method and later added to the AgNPs forming a more stable hybrid structure that was characterized using the UV-vis spectroscopy (UV-Vis), Nano zeta sizer, Raman spectroscopy, and the Fourier Infrared transmission resonance (FTIR). As the concentration of MO extract increased, the color change intensity increased symbolizing the formation of AgNPs while the luminous bright solutions under the UV light symbolized the formation of GQDs. This study lay the foundation for further research and analysis to be done on the nanozyme or biosensor application of enhanced functionalized and stable hybrid AgNPs with GQDs.
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Inya-Agha, Obianuju, Robert J. Forster, and Tia E. Keyes. "Noninvasive noble metal nanoparticle arrays for surface-enhanced Raman spectroscopy of proteins." In Biomedical Optics (BiOS) 2007, edited by Tuan Vo-Dinh and Joseph R. Lakowicz. SPIE, 2007. http://dx.doi.org/10.1117/12.725068.
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Sheridan, Eoin, Obianuju Inya-Agha, Tia Keyes, and Robert Forster. "Electrodeposited noble metal SERS: control of single nanoparticle size and control of array interparticle spacing." In Biomedical Optics (BiOS) 2007, edited by Tuan Vo-Dinh and Joseph R. Lakowicz. SPIE, 2007. http://dx.doi.org/10.1117/12.725069.
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Lapin, I. N., and V. A. Svetlichnyi. "Synthesis of noble metals nanoparticles in water by laser ablation method for biomedical applications and cosmetology." In 2012 IEEE 11th International Conference on Actual Problems of Electronics Instrument Engineering (APEIE). IEEE, 2012. http://dx.doi.org/10.1109/apeie.2012.6629029.
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Nedyalkov, N. N., Ru G. Nikov, and P. A. Atanasov. "Near field intensity enhancement and localization in noble metal nanoparticle ensembles." In Seventeenth International School on Quantum Electronics: Laser Physics and Applications, edited by Tanja N. Dreischuh and Albena T. Daskalova. SPIE, 2013. http://dx.doi.org/10.1117/12.2013200.
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Mayavan, S., N. R. Choudhury, and N. K. Dutta. "Polymer stabilized noble metal colloids for catalytic and biomedical applications." In Smart Materials, Nano-and Micro-Smart Systems, edited by Nicolas H. Voelcker and Helmut W. Thissen. SPIE, 2008. http://dx.doi.org/10.1117/12.810659.
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Brown, Paige K., Ammar T. Qureshi, Daniel J. Hayes, and W. Todd Monroe. "Targeted Gene Silencing With Light and a Silver Nanoparticle Antisense Delivery System." In ASME 2011 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2011. http://dx.doi.org/10.1115/sbc2011-53647.
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Targeted delivery and controlled release of oligonucleotide therapeutics in vivo are essential aspects of an ideal delivery vehicle. Here we demonstrate the synthesis and in vitro/intracellular characterization of silver nanoparticle (SNP) photolabile nucleic acid conjugates, with the aim of developing a nanoparticulate platform for inducible gene silencing. Due to unique size related properties, nanostructures are being increasingly utilized for intracellular diagnostics and delivery applications. While most nanoscale delivery platforms are polymeric in composition, studies of metallic nanoparticles have highlighted their suitability for delivery of therapeutic agents such as antisense oligonucleotides [1]. The potential benefits of noble metal nanoparticles in delivery applications include tunable size and shape, ease of bulk synthesis and functionalization via ‘wet chemistry’ techniques, and enhanced stability of tethered DNA [2]. Silver is one of the best surface-enhancing substrates available for nanostructure synthesis [3]. SNP composites afford external control over surface-tethered drug release via external triggers.
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Bayazitoglu, Yildiz. "Nanoshell Assisted Cancer Therapy: Numerical Simulations." In ASME 2009 Second International Conference on Micro/Nanoscale Heat and Mass Transfer. ASMEDC, 2009. http://dx.doi.org/10.1115/mnhmt2009-18546.
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Since the near infrared spectrum (wavelength range of 750–1100 nm) is the region of highest physiological transmisivity, it is the optical communication gateway for the laser energy to propagate into the human body. This optical window also leads to nanoparticle-based approach where embedded nanoparticles absorb the laser light designed to address the specific diagnostic and therapeutic challenges of cancer therapy is exploited extensively in so called plasmonic photo thermal therapy (PPTT). A new tool that is under development for cancer/tumor treatment, in which embedded nanoparticles are manipulated to absorb the Near Infrared (NIR) laser light intensely, aiming at addressing the “nonselectivity” problem that exists in the conventional photo thermal therapy (PPT). The purpose is to seek therapy with a faster and accurate procedure with a comprehensive treatment plan aided with fast and accurate numerical simulations as well. Among all the nanostructures, the noble metal nanoparticles (such as nanoshells) could be tuned to have peak absorption cross section in the NIR spectrum which provide very intense local heating to burn the deeply embedded cancerous tissues and tumors rather than the healthy tissue. Experimental and numerical studies have shown that designed gold nanoshells can be used to remotely and optically induce hyperthermia by embedding certain amount of absorbing dominated gold nanoshells in tumors and then irradiated using NIR laser light. Advancing our capabilities such as modeling, characterization and design of complex nanostructures and their host media for various nanophotonic applications will also increase our effectiveness of induced hyperthermia for its future applications. The computational tools should bridge across the scales from nano to macro, and rapidly compare the predicted behavior of a large number of nanoparticles embedded in tissue so that experimental groups could concentrate laboratory efforts on those resulted configurations most likely to provide optimum results.