Journal articles on the topic 'NNMT'
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Thomas, Martin G., Davide Sartini, Monica Emanuelli, Matthijs J. van Haren, Nathaniel I. Martin, David M. Mountford, David J. Barlow, et al. "Nicotinamide N-methyltransferase catalyses the N-methylation of the endogenous β-carboline norharman: evidence for a novel detoxification pathway." Biochemical Journal 473, no. 19 (September 27, 2016): 3253–67. http://dx.doi.org/10.1042/bcj20160219.
Full textYu, Tao, Yong-Tao Wang, Pan Chen, Yu-Hua Li, Yi-Xin Chen, Hang Zeng, Ai-Ming Yu, Min Huang, and Hui-Chang Bi. "Effects of Nicotinamide N-Methyltransferase on PANC-1 Cells Proliferation, Metastatic Potential and Survival Under Metabolic Stress." Cellular Physiology and Biochemistry 35, no. 2 (2015): 710–21. http://dx.doi.org/10.1159/000369731.
Full textLiu, Wenxiu, Meng Zhu, Xiaoming Li, Limian Er, and Shengmian Li. "NNMT Is an Immune-Related Prognostic Biomarker That Modulates the Tumor Microenvironment in Pan-Cancer." Disease Markers 2023 (February 9, 2023): 1–17. http://dx.doi.org/10.1155/2023/9226712.
Full textSun, Wei, Yongxiang Zou, Zheng Cai, Jinxiang Huang, Xinjie Hong, Qiang Liang, and Weilin Jin. "Overexpression of NNMT in Glioma Aggravates Tumor Cell Progression: An Emerging Therapeutic Target." Cancers 14, no. 14 (July 21, 2022): 3538. http://dx.doi.org/10.3390/cancers14143538.
Full textParsons, Richard B., Shylesh Aravindan, Anusha Kadampeswaran, Emily A. Evans, Kanwaljeet K. Sandhu, Elizabeth R. Levy, Martin G. Thomas, Brian M. Austen, and David B. Ramsden. "The expression of nicotinamide N-methyltransferase increases ATP synthesis and protects SH-SY5Y neuroblastoma cells against the toxicity of Complex I inhibitors." Biochemical Journal 436, no. 1 (April 27, 2011): 145–55. http://dx.doi.org/10.1042/bj20101685.
Full textZhang, Weixian, Yue Jing, Shuai Wang, Yan Wu, Yawei Sun, Jia Zhuang, Xiaofeng Huang, et al. "Identification of Biological Functions and Prognostic Value of NNMT in Oral Squamous Cell Carcinoma." Biomolecules 12, no. 10 (October 15, 2022): 1487. http://dx.doi.org/10.3390/biom12101487.
Full textParsons, Richard B., and Paul D. Facey. "Nicotinamide N-Methyltransferase: An Emerging Protagonist in Cancer Macro(r)evolution." Biomolecules 11, no. 10 (September 28, 2021): 1418. http://dx.doi.org/10.3390/biom11101418.
Full textLiu, Jie-Ru, Zhao-Hui Deng, Xiao-Juan Zhu, Yu-Rong Zeng, Xiang-Xiang Guan, and Jiang-Hua Li. "Roles of Nicotinamide N-Methyltransferase in Obesity and Type 2 Diabetes." BioMed Research International 2021 (July 27, 2021): 1–8. http://dx.doi.org/10.1155/2021/9924314.
Full textGriffiths, Alexandra, Jun Wang, Qing Song, Iredia D. Iyamu, Lifeng Liu, Jooman Park, Yuwei Jiang, Rong Huang, and Zhenyuan Song. "Nicotinamide N-methyltransferase upregulation via the mTORC1-ATF4 pathway activation contributes to palmitate-induced lipotoxicity in hepatocytes." American Journal of Physiology-Cell Physiology 321, no. 3 (September 1, 2021): C585—C595. http://dx.doi.org/10.1152/ajpcell.00195.2021.
Full textLi, Guoli, Sining Fang, Xiao Shao, Yejia Li, Qingchao Tong, Beibei Kong, Lifen Chen, et al. "Curcumin Reverses NNMT-Induced 5-Fluorouracil Resistance via Increasing ROS and Cell Cycle Arrest in Colorectal Cancer Cells." Biomolecules 11, no. 9 (August 31, 2021): 1295. http://dx.doi.org/10.3390/biom11091295.
Full textSartini, Davide, Riccardo Seta, Valentina Pozzi, Stefano Morganti, Corrado Rubini, Antonio Zizzi, Marco Tomasetti, Lory Santarelli, and Monica Emanuelli. "Role of nicotinamide N-methyltransferase in non-small cell lung cancer: in vitro effect of shRNA-mediated gene silencing on tumourigenicity." Biological Chemistry 396, no. 3 (March 1, 2015): 225–34. http://dx.doi.org/10.1515/hsz-2014-0231.
Full textHuang, Rong, and Iredia Iyamu. "Abstract A024: Development of potent and selective nicotinamide N-methyltransferase inhibitors for kidney cancer." Cancer Research 83, no. 16_Supplement (August 15, 2023): A024. http://dx.doi.org/10.1158/1538-7445.kidney23-a024.
Full textWang, Wenxuan, Wenzheng Li, Ying Bu, Xuepeng Li, and Wenhui Zhu. "Nano Freezing–Thawing of Atlantic Salmon Fillets: Impact on Thermodynamic and Quality Characteristics." Foods 12, no. 15 (July 29, 2023): 2887. http://dx.doi.org/10.3390/foods12152887.
Full textHeide, Janna, Andras Piffko, Agnes J. Bilecz, Ethan A. Teich, Lisa Schweizer, Sayed R. Alhunayan, Kaiting Yang, and Ernst Lengyel. "Abstract 4462: Immunoregulatory effects of NNMT-expressing cancer-associated fibroblasts." Cancer Research 83, no. 7_Supplement (April 4, 2023): 4462. http://dx.doi.org/10.1158/1538-7445.am2023-4462.
Full textChee, Woei-Yaw, Deniz Nesli Dolcen, Lynda Bennett, and Suzanne D. Conzen. "Abstract 3697: Modulation of Nicotinamide N-Methyl Transferase (NNMT) expression in TNBC is associated with altered cell membrane cholesterol levels." Cancer Research 83, no. 7_Supplement (April 4, 2023): 3697. http://dx.doi.org/10.1158/1538-7445.am2023-3697.
Full textMa, Lianping, and Ming Li. "Abstract 2545: NNMT is a novel effector of EGFR driven glioblastoma malignancy." Cancer Research 83, no. 7_Supplement (April 4, 2023): 2545. http://dx.doi.org/10.1158/1538-7445.am2023-2545.
Full textDang, Ling, and Yingdong Wang. "Prognostic value of nicotinamide N-methyltransferase in human cancers: Evidence from a meta-analysis and database validation." Open Medicine 17, no. 1 (January 1, 2022): 292–303. http://dx.doi.org/10.1515/med-2022-0413.
Full textTogni, Lucrezia, Marco Mascitti, Davide Sartini, Roberto Campagna, Valentina Pozzi, Eleonora Salvolini, Annamaria Offidani, Andrea Santarelli, and Monica Emanuelli. "Nicotinamide N-Methyltransferase in Head and Neck Tumors: A Comprehensive Review." Biomolecules 11, no. 11 (October 28, 2021): 1594. http://dx.doi.org/10.3390/biom11111594.
Full textLiang, Tairong, Xiuqian Wu, Lan Wang, Tiantian Song, Peishan Wu, Yongdong Niu, and Haihua Huang. "Correlation of NNMT and DKK1 Protein Expression With Clinicopathological Characteristics and Prognosis of Breast Cancer." Clinical Medicine Insights: Oncology 17 (January 2023): 117955492311680. http://dx.doi.org/10.1177/11795549231168073.
Full textLi, Qian, Min-Di He, Lin Mao, Xue Wang, Yu-Lin Jiang, Min Li, Yong-Hui Lu, Zheng-Ping Yu, and Zhou Zhou. "Nicotinamide N-Methyltransferase Suppression Participates in Nickel-Induced Histone H3 Lysine9 Dimethylation in BEAS-2B Cells." Cellular Physiology and Biochemistry 41, no. 5 (2017): 2016–26. http://dx.doi.org/10.1159/000475432.
Full textPozzi, Valentina, Giulia Di Ruscio, Davide Sartini, Roberto Campagna, Riccardo Seta, Paola Fulvi, Alexia Vici, et al. "Clinical performance and utility of a NNMT-based urine test for bladder cancer." International Journal of Biological Markers 33, no. 1 (November 11, 2017): 94–101. http://dx.doi.org/10.5301/ijbm.5000311.
Full textCampagna, Roberto, Valentina Pozzi, Graziana Spinelli, Davide Sartini, Giulio Milanese, Andrea Benedetto Galosi, and Monica Emanuelli. "The Utility of Nicotinamide N-Methyltransferase as a Potential Biomarker to Predict the Oncological Outcomes for Urological Cancers: An Update." Biomolecules 11, no. 8 (August 16, 2021): 1214. http://dx.doi.org/10.3390/biom11081214.
Full textKoppe, Tiago De Bone, Bonnie Patchen, Aaron Cheng, Manoj Bhasin, Chris D. Vulpe, Jose M. Fernandez-Real, Robert K. Schwartz, Pavlos Pissios, and Paula G. Fraenkel. "Nicotinamide N-Methyltransferase Expression Decreases in Iron Overload Exacerbating Iron-Induced Hepatotoxicity." Blood 128, no. 22 (December 2, 2016): 204. http://dx.doi.org/10.1182/blood.v128.22.204.204.
Full textKannt, Aimo, Sridharan Rajagopal, Mahanandeesha S. Hallur, Indu Swamy, Rajendra Kristam, Saravanakumar Dhakshinamoorthy, Joerg Czech, Gernot Zech, Herman Schreuder, and Sven Ruf. "Novel Inhibitors of Nicotinamide-N-Methyltransferase for the Treatment of Metabolic Disorders." Molecules 26, no. 4 (February 13, 2021): 991. http://dx.doi.org/10.3390/molecules26040991.
Full textRamsden, David B., Rosemary H. Waring, Richard B. Parsons, David J. Barlow, and Adrian C. Williams. "Nicotinamide N-Methyltransferase: Genomic Connection to Disease." International Journal of Tryptophan Research 13 (January 2020): 117864692091977. http://dx.doi.org/10.1177/1178646920919770.
Full textde Jonge, Robert, Wim J. E. Tissing, Jan Hendrik Hooijberg, Gerrit Jansen, Gertjan J. L. Kaspers, Jan Lindemans, Godefridus J. Peters, and Rob Pieters. "Polymorphisms in folate-related genes and risk of pediatric acute lymphoblastic leukemia." Blood 113, no. 10 (March 5, 2009): 2284–89. http://dx.doi.org/10.1182/blood-2008-07-165928.
Full textKim, Dong Su, Won Sik Ham, Won Sik Jang, Kang Su Cho, Young Deuk Choi, Suki Kang, Bora Kim, et al. "Scale-Up Evaluation of a Composite Tumor Marker Assay for the Early Detection of Renal Cell Carcinoma." Diagnostics 10, no. 10 (September 25, 2020): 750. http://dx.doi.org/10.3390/diagnostics10100750.
Full textBai, Zhigang, Dongli Zhang, and Enhong Shi. "Long non-coding RNA opa-interacting protein 5 antisense transcript 1 (LncRNA OIP5-AS1) promoted cisplatin resistance in nasopharyngeal carcinoma via the miR-378a-3p/nicotinamide N-methyltransferase axis." Materials Express 12, no. 7 (July 1, 2022): 980–87. http://dx.doi.org/10.1166/mex.2022.2219.
Full textNovak Kujundžić, Renata, Marin Prpić, Nikola Đaković, Nina Dabelić, Marko Tomljanović, Anamarija Mojzeš, Ana Fröbe, and Koraljka Gall Trošelj. "Nicotinamide N-Methyltransferase in Acquisition of Stem Cell Properties and Therapy Resistance in Cancer." International Journal of Molecular Sciences 22, no. 11 (May 26, 2021): 5681. http://dx.doi.org/10.3390/ijms22115681.
Full textPozzi, Valentina, Roberto Campagna, Davide Sartini, and Monica Emanuelli. "Nicotinamide N-Methyltransferase as Promising Tool for Management of Gastrointestinal Neoplasms." Biomolecules 12, no. 9 (August 24, 2022): 1173. http://dx.doi.org/10.3390/biom12091173.
Full textZhou, Qiong, Xiao-Juan Zhu, and Jiang-Hua Li. "Association between Nicotinamide N-Methyltransferase Gene Polymorphisms and Obesity in Chinese Han Male College Students." BioMed Research International 2017 (2017): 1–6. http://dx.doi.org/10.1155/2017/2984826.
Full textDeBasli, Karen L., John H. Newman, Laura J. Sommerville, John A. Phillips, Rizwan Hamid, Joy Cogan, Joshua P. Fessel, Anne M. Evans, and Adam D. Kennedy. "A Case Study of Dysfunctional Nicotinamide Metabolism in a 20-Year-Old Male." Metabolites 13, no. 3 (March 8, 2023): 399. http://dx.doi.org/10.3390/metabo13030399.
Full textBockwoldt, Mathias, Dorothée Houry, Marc Niere, Toni I. Gossmann, Ines Reinartz, Alexander Schug, Mathias Ziegler, and Ines Heiland. "Identification of evolutionary and kinetic drivers of NAD-dependent signaling." Proceedings of the National Academy of Sciences 116, no. 32 (July 24, 2019): 15957–66. http://dx.doi.org/10.1073/pnas.1902346116.
Full textvan Haren, Matthijs J., Rebecca Taig, Jilles Kuppens, Javier Sastre Toraño, Ed E. Moret, Richard B. Parsons, Davide Sartini, Monica Emanuelli, and Nathaniel I. Martin. "Inhibitors of nicotinamide N-methyltransferase designed to mimic the methylation reaction transition state." Organic & Biomolecular Chemistry 15, no. 31 (2017): 6656–67. http://dx.doi.org/10.1039/c7ob01357d.
Full textCampagna, Roberto, Valentina Pozzi, Davide Sartini, Eleonora Salvolini, Valerio Brisigotti, Elisa Molinelli, Anna Campanati, Annamaria Offidani, and Monica Emanuelli. "Beyond Nicotinamide Metabolism: Potential Role of Nicotinamide N-Methyltransferase as a Biomarker in Skin Cancers." Cancers 13, no. 19 (September 30, 2021): 4943. http://dx.doi.org/10.3390/cancers13194943.
Full textSartini, Davide, Valentina Pozzi, Elisabetta Renzi, Stefano Morganti, Romina Rocchetti, Corrado Rubini, Andrea Santarelli, Lorenzo Lo Muzio, and Monica Emanuelli. "Analysis of tissue and salivary nicotinamide N-methyltransferase in oral squamous cell carcinoma: basis for the development of a noninvasive diagnostic test for early-stage disease." Biological Chemistry 393, no. 6 (June 1, 2012): 505–11. http://dx.doi.org/10.1515/hsz-2012-0112.
Full textHasan, Eman M., Rasha A. Abd Al Aziz, Dina Sabry, Samar K. Darweesh, Hedy A. Badary, Aisha Elsharkawy, Mahmood M. Abouelkhair, and Ayman Yosry. "Genetic Variants in Nicotinamide-N-Methyltransferase (NNMT) Gene are Related to the Stage of Non-Alcoholic Fatty Liver Disease Diagnosed by Controlled Attenuation Parameter (CAP)-FibroScan." Journal of Gastrointestinal and Liver Diseases 27, no. 3 (September 30, 2018): 265–72. http://dx.doi.org/10.15403/jgld.2014.1121.273.wsh.
Full textHuang, Hao, Guangyuan Zhao, Andres Felipe Valdivia, Horacio Cardenas, Yinu Wang, and Daniela Daniela Matei. "Abstract 5359: M6A regulated NNMT mediates resistance to platinum in ovarian cancer." Cancer Research 82, no. 12_Supplement (June 15, 2022): 5359. http://dx.doi.org/10.1158/1538-7445.am2022-5359.
Full textBabault, Nicolas, Abdellah Allali-Hassani, Fengling Li, Jie Fan, Alex Yue, Kevin Ju, Feng Liu, Masoud Vedadi, Jing Liu, and Jian Jin. "Discovery of Bisubstrate Inhibitors of Nicotinamide N-Methyltransferase (NNMT)." Journal of Medicinal Chemistry 61, no. 4 (January 31, 2018): 1541–51. http://dx.doi.org/10.1021/acs.jmedchem.7b01422.
Full textGao, Yongzhi, Matthijs J. van Haren, Ed E. Moret, Johannes J. M. Rood, Davide Sartini, Alessia Salvucci, Monica Emanuelli, et al. "Bisubstrate Inhibitors of NicotinamideN-Methyltransferase (NNMT) with Enhanced Activity." Journal of Medicinal Chemistry 62, no. 14 (July 2, 2019): 6597–614. http://dx.doi.org/10.1021/acs.jmedchem.9b00413.
Full textLiu, Wenxiu, Hongyan Gou, Xiaohong Wang, Xiaoming Li, Xiaoxu Hu, Hao Su, Shengmian Li, and Jun Yu. "TTPAL promotes gastric tumorigenesis by directly targeting NNMT to activate PI3K/AKT signaling." Oncogene 40, no. 49 (October 12, 2021): 6666–79. http://dx.doi.org/10.1038/s41388-021-01838-x.
Full textZhu, Xiao-Juan, Ya-Jun Lin, Wei Chen, Ya-Hui Wang, Li-Qiang Qiu, Can-Xin Cai, Qun Xiong, et al. "Physiological Study on Association between Nicotinamide N-Methyltransferase Gene Polymorphisms and Hyperlipidemia." BioMed Research International 2016 (2016): 1–8. http://dx.doi.org/10.1155/2016/7521942.
Full textRivas, Maria Prates, Talita Ferreira Marques Aguiar, Mariana Maschietto, Renan B. Lemes, Luiz Carlos Caires-Júnior, Ernesto Goulart, Kayque Alves Telles-Silva, et al. "Hepatoblastomas exhibit marked NNMT downregulation driven by promoter DNA hypermethylation." Tumor Biology 42, no. 12 (November 30, 2020): 101042832097712. http://dx.doi.org/10.1177/1010428320977124.
Full textLo Muzio, L., L. Lo Russo, A. Santarelli, D. Sartini, C. Rubini, C. Di Liberto, O. Di Fede, V. Rossi, and M. Emanuelli. "P249 NNMT expression and prognosis in oral squamous cell carcinoma." Oral Oncology Supplement 2, no. 1 (May 2007): 206. http://dx.doi.org/10.1016/s1744-7895(07)70526-6.
Full textPolicarpo, Rocco L., Ludovic Decultot, Elizabeth May, Petr Kuzmič, Samuel Carlson, Danny Huang, Vincent Chu, et al. "High-Affinity Alkynyl Bisubstrate Inhibitors of Nicotinamide N-Methyltransferase (NNMT)." Journal of Medicinal Chemistry 62, no. 21 (October 7, 2019): 9837–73. http://dx.doi.org/10.1021/acs.jmedchem.9b01238.
Full textTrammell, Samuel A. J., and Charles Brenner. "NNMT: A Bad Actor in Fat Makes Good in Liver." Cell Metabolism 22, no. 2 (August 2015): 200–201. http://dx.doi.org/10.1016/j.cmet.2015.07.017.
Full textvan Haren, Matthijs J., Yongzhi Gao, Ned Buijs, Roberto Campagna, Davide Sartini, Monica Emanuelli, Lukasz Mateuszuk, et al. "Esterase-Sensitive Prodrugs of a Potent Bisubstrate Inhibitor of Nicotinamide N-Methyltransferase (NNMT) Display Cellular Activity." Biomolecules 11, no. 9 (September 14, 2021): 1357. http://dx.doi.org/10.3390/biom11091357.
Full textWilliams, Adrian C., Lisa J. Hill, and David B. Ramsden. "Nicotinamide, NAD(P)(H), and Methyl-Group Homeostasis Evolved and Became a Determinant of Ageing Diseases: Hypotheses and Lessons from Pellagra." Current Gerontology and Geriatrics Research 2012 (2012): 1–24. http://dx.doi.org/10.1155/2012/302875.
Full textSabnis, Ram W. "Novel Pyrimidine-5-carboxamide Compounds as NNMT Inhibitors for Treating Diabetes." ACS Medicinal Chemistry Letters 12, no. 4 (March 26, 2021): 538–39. http://dx.doi.org/10.1021/acsmedchemlett.1c00150.
Full textKanska, Justyna, Paul-Joseph P. Aspuria, Barbie Taylor-Harding, Lindsay Spurka, Vincent Funari, Sandra Orsulic, Beth Y. Karlan, and W. Ruprecht Wiedemeyer. "Glucose deprivation elicits phenotypic plasticity via ZEB1-mediated expression of NNMT." Oncotarget 8, no. 16 (February 17, 2017): 26200–26220. http://dx.doi.org/10.18632/oncotarget.15429.
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