Relevant bibliographies by topics / Nitrofuran antibiotics

Academic literature on the topic 'Nitrofuran antibiotics'

Author: Grafiati
Published: 4 June 2021
Last updated: 9 February 2022

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Journal articles on the topic "Nitrofuran antibiotics"

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Vass, M., K. Hruska, and M. Franek. "Nitrofuran antibiotics: a review on the application, prohibition and residual analysis." Veterinární Medicína 53, No. 9 (October 16, 2008): 469–500. http://dx.doi.org/10.17221/1979-vetmed.

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Nitrofuran antibiotics, employed for the treatment of bacterial diseases in livestock production, were banned from use in the European Union (EU) in 1995 due to concerns about the carcinogenicity of their residues in edible tissue. This review provides an overview of nitrofuran toxicity, metabolism, and also specific aspects of legislation surrounding their prohibition. Special attention is devoted to semicarbazide – a nitrofuran metabolite and food contaminant. Analytical procedures for nitrofuran analysis in various matrices and validation requirements for screening and confirmation methods with respect to EU regulations are also reviewed.
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Bayer, O. V., O. S. Yaremchuk, T. V. Yevtushenko, L. V. Shevchenko, V. M. Mykhalska, Yu V. Dobrozhan, Ya V. Dovhopol, and R. L. Varpikhovskyi. "Розробка та оцінка придатності методу визначення нітрофуранів в меді за допомогою рідинної хроматографії високого тиску – тандемної мас-спектрометрії (UPLC-MS-MS)." Ukrainian Journal of Ecology 8, no. 1 (March 25, 2018): 966–74. http://dx.doi.org/10.15421/2018_300.

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<p><span lang="UK">Over the past decade, Ukraine has been one of the leaders in exporting honey to EU countries. The main obstacle to increasing the export of Ukrainian honey to EU countries is the discrepancy of honey safety indicators with the requirements of importing countries. This is due to the use of a significant number of drugs with antimicrobial spectrum of action in the treatment and prevention of diseases of bees, the remains of which fall into honey. In domestic honey, according to recent data, the remains of such groups of antibiotics and antimicrobial agents as chloramphenicol, nitrofuran, nitroimidazole, sulfanilamides, tetracyclines and aminoglycosides are most commonly found.</span><span lang="EN-US">The nitrofurans, which are quite stable, can be stored in honey for a long time and are not destroyed even at high temperatures. Therefore, the urgent question remains the development and introduction into practice of laboratory analysis of a sensitive and reliable method for determining the residual amounts of nitrofurans in honey.The method developed by us allows us to determine the residual amounts of metabolites of nitrofurans in honey, namely: furazolidone derivative - 3-amino-2-oxazolidinone (AOZ), furaltadone-3-amino-5-morpholinomethyl-2-oxazolidinone (AMOZ), nitrofurase-semicarbazide SEM) and nitrofurantoin-1-aminohydandomine (AHD).The use of drugs nitrofuran number in the treatment and prevention of infectious diseases of bees involves the receipt of their metabolites in honey in the human body.The conducted studies revealed that nitrofurantoin (38% of honey samples) was used most often in beekeeping, followed by fureladone (24%), while nitrofurase and furazolidone were used equally in 19% of honey samples, respectively.The conducted studies revealed 4 metabolites of nitrofurans in natural honey, namely the metabolite furazolidone 3-amino-2-oxazolidinone (AOZ), nitrofurase-semicarbazide (SEM), furaltadone-3-amino-5-morpholinomethyl-2-oxazolidinone (AMOZ), and nitrofurantoin - 1-aminohydandomine (AHD).The content of 3-amino-2-oxazolidinone (AOZ) and semicarbazide (SEM) in honey exceeds the MDR by the norms of Ukraine. According to EU norms, the content of 3-amino-2-oxazolidinone (AOZ), 3-amino-5-morpholinomethyl-2-oxazolidinone (AMOZ) and 1-aminohydinotin (AHD) in honey exceeds MDR and the semicarbazide content (SEM) permissible concentration.</span></p>
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Edhlund, Betsy L., William A. Arnold, and Kristopher McNeill. "Aquatic Photochemistry of Nitrofuran Antibiotics." Environmental Science & Technology 40, no. 17 (September 2006): 5422–27. http://dx.doi.org/10.1021/es0606778.

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Saqib, Muhammad, Eugene Arthur-Baidoo, Milan Ončák, and Stephan Denifl. "Electron Attachment Studies with the Potential Radiosensitizer 2-Nitrofuran." International Journal of Molecular Sciences 21, no. 23 (November 24, 2020): 8906. http://dx.doi.org/10.3390/ijms21238906.

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Nitrofurans belong to the class of drugs typically used as antibiotics or antimicrobials. The defining structural component is a furan ring with a nitro group attached. In the present investigation, electron attachment to 2-nitrofuran (C4H3NO3), which is considered as a potential radiosensitizer candidate for application in radiotherapy, has been studied in a crossed electron–molecular beams experiment. The present results indicate that low-energy electrons with kinetic energies of about 0–12 eV effectively decompose the molecule. In total, twelve fragment anions were detected within the detection limit of the apparatus, as well as the parent anion of 2-nitrofuran. One major resonance region of ≈0–5 eV is observed in which the most abundant anions NO2−, C4H3O−, and C4H3NO3− are detected. The experimental results are supported by ab initio calculations of electronic states in the resulting anion, thermochemical thresholds, connectivity between electronic states of the anion, and reactivity analysis in the hot ground state.
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Rusen, Edina, Aurel Diacon, Alexandra Mocanu, Florica Rizea, Bogdan Bucur, Madalina Petruta Bucur, Gabriel-Lucian Radu, Elena Bacalum, Mihaela Cheregi, and Victor David. "Synthesis and retention properties of molecularly imprinted polymers for antibiotics containing a 5-nitrofuran ring." RSC Advances 7, no. 80 (2017): 50844–52. http://dx.doi.org/10.1039/c7ra10196a.

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Toogood, Helen S., and Nigel S. Scrutton. "Flavin oxidation state impacts on nitrofuran antibiotic binding orientation in nitroreductases." Biochemical Journal 478, no. 18 (September 23, 2021): 3423–28. http://dx.doi.org/10.1042/bcj20210489.

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Nitroreductases catalyse the NAD(P)H-dependent nitro reduction in nitrofuran antibiotics, which activates them into cytotoxic molecules leading to cell death. The design of new effective nitrofuran antibiotics relies on knowledge of the kinetic mechanism and nitrofuran binding mode of microbial nitroreductases NfsA and NfsB. This has been hampered by multiple co-crystallisation studies revealing ligand binding in non-electron transfer competent states. In a recent study by Day et al. (2021) the authors investigated the likely reaction mechanism and mode of nitrofurantoin binding to NfsA using potentiometry, global kinetics analysis, crystallography and molecular dynamics simulations. Their findings suggest nitrofurantoin reduction proceeds via a direct hydride transfer from reduced FMN, while the crystallographic binding orientation is an inhibitory complex. Molecular dynamics simulations suggest ligand binding orientations is dependent on the oxidation state of the FMN. This study highlights the importance of utilising computational studies alongside traditional crystallographic approaches, when multiple stable ligand binding orientations can occur.
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Shi, Lulu, Mei Liu, Cao Fang, Xiaofei Zhu, and Hui Li. "A cucurbit[6]uril-based supramolecular assembly test strip for immediate detection of nitrofuran antibiotics in water." CrystEngComm 22, no. 44 (2020): 7660–67. http://dx.doi.org/10.1039/d0ce01294g.

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Nowsad, AKM, MR Islam, and MAR Faruk. "Studies on Nitrofuran Contamination in Exportable Shrimp and Prawn Products." Progressive Agriculture 20, no. 1-2 (November 5, 2013): 143–51. http://dx.doi.org/10.3329/pa.v20i1-2.16866.

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For the last few years, several consignments of frozen prawn and shrimp from Bangladesh have been rejected by the EU and USA due to presence of nitrofuran drugs. We have investigated the source of nitrofuran drugs in shrimp and prawn through participatory stakeholder based approach. Survey in greater Mymensingh region revealed that most of the hatchery operators and prawn farmers did not know about the devastating effect of nitrofuran on prawn while survey in Cox’s Bazar and Khulna revealed that most of the hatchery operators knew about the nitrofuran drugs but they kept mum on nitrofuran related issues. A series of antibiotics sold in local veterinary drug shops of Cox’s Bazar and Khulna were found to be used in shrimp hatcheries. While conducting stakeholder based dialogue in Khulna and Cox’s Bazar, hatchery operators were directly blamed by shrimp/prawn farmers, depot holders and processors for using nitrofuran drug. Many hatchery technicians mentioned that they used nitrofuran drugs in the hatcheries 5-6 years back, much before than it was declared banned on shrimp products, but at present they were not using it. While asking about the unlabelled drugs using in their hatcheries, they did not respond but mentioned the efficacy of nitrofuran in the survival of shrimp/prawn PL and promotion of their growth. From the participatory stakeholder based study it was understood that both the prawn/shrimp hatchery and poultry feed/fish feed used as shrimp/prawn feed in grow out ponds might be the possible sources of contamination of nitrofuran drugs in exportable shrimp/prawn products.DOI: http://dx.doi.org/10.3329/pa.v20i1-2.16866 Progress. Agric. 20(1 & 2): 143 – 151, 2009
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Wang, Yinan, K. K. Jason Chan, and Wan Chan. "Plant Uptake and Metabolism of Nitrofuran Antibiotics in Spring Onion Grown in Nitrofuran-Contaminated Soil." Journal of Agricultural and Food Chemistry 65, no. 21 (May 18, 2017): 4255–61. http://dx.doi.org/10.1021/acs.jafc.7b01050.

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Zhang, Yujuan, Jiandong Yang, Dongsheng Zhao, Zhangjie Liu, Dacheng Li, Liming Fan, and Tuoping Hu. "Two cadmium(ii) coordination polymers as luminescent sensors for the detection of nitrofuran/nitroimidazole antibiotics." CrystEngComm 21, no. 41 (2019): 6130–35. http://dx.doi.org/10.1039/c9ce01164a.

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p-Terphenyl-2,2′′,5′′,5′′-tetracarboxylate acid and bis(imidazol-1-ylmethyl)benzene-based two Cd(ii) coordination polymers act as the luminescent sensors for the detection of nitrofuran/nitroimidazole antibiotics.
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Dissertations / Theses on the topic "Nitrofuran antibiotics"

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Wickramanayake, Priyanga, and s3028858@student rmit edu au. "Applications of chiral selectors and replaceable supports for capillary electrophoretic separations." RMIT University. Applied Chemistry, 2007. http://adt.lib.rmit.edu.au/adt/public/adt-VIT20080617.115607.

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The popularity of capillary electrophoresis (CE) as a separation technique has been established over the years. CE offers the advantages of high resolution, high separation efficiency, fast approaches of method development, a range of operational modes and low consumption of reagents. The strategy employed here for the development of chromatographic separations involved the utilization of experimental designs, multi-linear regression and response surface methodology to build empirical models that related the chromatographic quality to the factors influencing the separation. Separation of Nitrofuran antibiotics (NFAs) and their metabolites (NFMs) by using micellar electrokinetic capillary chromatography was successfully completed. The best conditions found to give optimum resolution from the optimization study was pH 9.0, 80 mM SDC concentration, 16 kV with running buffer consisting of 20 mM borate and 20 mM phosphate concentration using a 73 cm x 75 ƒÝm column, resulting in completely resolved NFAs and NFMs within 16 min. It is interesting that all the compounds can be reliably separated with the one mixture, and single CE condition. Whilst all antibiotics have shorter migration time than their respective derivatised metabolites, as a group apart from nitrofurantoin the antibiotics elute before the metabolites. The analytical figures of merit for CE analysis exhibited excellent reproducibility of absolute and relative migration times, and acceptable reproducibility of relative response areas. Successful separation of metabolite derivatives was achieved when the developed method was applied to a spiked prawn sample. The chiral separation of Triadimenol was successfully completed using micellar electrokinetic capillary chromatography. The best conditions found to give optimum resolution from the optimisation study were pH 6.0, 20% methanol, 50 mM SDS concentration, 18 kV with running buffer consisting of 20 mM borate and 20 mM phosphate concentration using a 64.5 cm x 50 ƒÝm column, resulted in baseline resolution of all Triadimenol isomers within 18 min. The optimised separation conditions were applied to a blank grape sample and to a spiked grape sample. No peaks were observed in the blank grape sample whereas the spiked grape sample had two diastereoismer peaks with poor detection sensitivity. Increase in detection sensitivity is necessary to determine the possibility of resolution of all the isomers of Triadimenol, in the spiked grape sample and the blank. Online preconcentration techniques were attempted to for Triadimenol isomer separation. When using online preconcentration technique of sweeping, a 30-fold increase in detection sensitivity of Triadimenol was observed compared to MEKC mode. However enantiomer separation was not possible with sulfated-£]-CD chiral selector. The best conditions were found to be pH 2.5, 50 mM SDS concentration, -20 kV with running buffer consisting of 20 mM phosphate concentration, using a 64.5 cm x 50 ƒÝm column, resulting in diastereoisomer separation within 8 min. Final stage of the project was to create stationary phase beds in capillaries and micro-channels that could be removed and re-created, thus providing a fresh stationary phase. The replaceable stationary phase (RSP) can be used as an operating mode of CE/CEC. Preparation of reversible stationary phase (RSP) inside the capillary column was successfully performed using low methoxy pectin (LMP). LMP renders a capability of reversible thermogelation. Electroosmotic flow (EOF) and sufficient hydrophobicity of LMP gel allow separation of analyates. The porosity of LMP RSP was adequate to support EOF. Successful separation with good reproducibility of areas and migration times was obtained for Caffeine, Aspartame, Benzoic acid, Saccharine (CABS) mixture and NFAs. After performing continuous analyses, the aging of RSP was observed. Temperature was the ¡¥switch¡¦, which applied to remove aged RSP. RSP was recreated for further analysis of analytes. RSP was UV transparent, capable of handling various analytes and diff erent buffer electrolytes including aqueous-organic solvents.
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Muaksang, Kittiya Chemistry Faculty of Science UNSW. "Development of reference methods and reference materials for trace level antibiotic residues in food using IDMS." Awarded by:University of New South Wales. Chemistry, 2009. http://handle.unsw.edu.au/1959.4/43262.

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Food additives, drugs and growth-enhancing compounds are prominent tools in the production of sufficient quantities of affordable food. Thus, food safety has become a main concern of many countries for protection of their population's health. Analytical chemical measurements are increasingly important to ensure consumer protection, particularly in the field of antibiotic residues. International comparability and reliability of measurement results can be achieved by establishing and demonstrating the metrological traceability of those results to the International System of Units (SI). To ensure the metrological traceability of measurement results, reference methods and certified reference materials (CRMs) are needed. Nitrofuran antibiotic drugs used for the treatment of bacterial and protozoan infections in animals were studied in this thesis. A high accuracy reference method and an appropriate CRM for the detection of nitrofurans in prawns have been developed. A reference method for the measurement of mass fractions of nitrofuran metabolites 3-amino-5-methyl-morpholino-2-oxazolidinone (AMOZ), 3-amino-2-oxazolidinone (AOZ), semicarbazide (SEM) and 1-aminohydantoin (AHD) has been developed utilising an exact matching double isotope dilution mass spectrometry (IDMS) method. A feasibility study on a fortified reference material was carried out by preparing fortified samples containing the four nitrofuran metabolites. The stability testing results showed that the analytes in the freeze-dried matrix were more stable than in the wet form. Freeze-dried certified reference materials of nitrofurans in prawns have been produced; an incurred AOZ (CRM_P1) and incurred AOZ and fortified SEM (CRM_P2). The reference method developed was applied for the characterisation of certified reference materials for homogeneity, stability study and certification. The prepared certified reference materials were found to be homogeneous and remained stable under normal transport conditions. The measurement uncertainty of the measurement results obtained by the reference method developed was determined by thoroughly examining all possible sources of potential bias and precision effects. An initial measurement uncertainty for certified values of AOZ in both materials has also been estimated. Metrological traceability of measurement results obtained by the developed reference method and the reference value of the prepared certified reference materials has been established through the use of the traceable primary ratio method of exact matching double IDMS, the use of certified nitrofuran metabolite standards, and gravimetric preparation of samples.
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Howe, Christopher Ryan. "Analogues of Nitrofuran Antibiotics are Potent GroEL/ES Pro-drug Inhibitors with Efficacy against Enterococcus Faecium, Staphylococcus Aureus, and Escherichia Coli." Thesis, 2020. http://hdl.handle.net/1805/22885.

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Books on the topic "Nitrofuran antibiotics"

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NTP technical report on the toxicology and carcinogenesis studies of nitrofurantoin (CAS no. 67-20-9) in F344/N rats and B6C3F₁ mice (feed studies). Research Triangle Park, NC (P.O. Box 12233, Research Triangle Park 27709): The Program, 1989.

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Book chapters on the topic "Nitrofuran antibiotics"

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Grayson, M., and Michael Whitby. "Nitrofurans." In Kucers' The Use of Antibiotics Sixth Edition, 1195–204. CRC Press, 2010. http://dx.doi.org/10.1201/b13787-100.

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Conference papers on the topic "Nitrofuran antibiotics"

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Juan Wu, Ye Chen, and Dong Ma. "Degradation of nitrofuran antibiotics in water by ozonation." In 2011 International Conference on Remote Sensing, Environment and Transportation Engineering (RSETE). IEEE, 2011. http://dx.doi.org/10.1109/rsete.2011.5964714.

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Pacholak, Amanda, and Ewa Kaczorek. "The Role of Selected Environmental Bacteria in Decomposition of Nitrofuran Antibiotics." In The 5th World Congress on New Technologies. Avestia Publishing, 2019. http://dx.doi.org/10.11159/icepr19.134.

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