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1
Di Bari, Virginia, Gina Gualano, Maria Musso, Raffaella Libertone, Carla Nisii, Stefania Ianniello, Silvia Mosti, et al. "Increased Association of Pulmonary Thromboembolism and Tuberculosis during COVID-19 Pandemic: Data from an Italian Infectious Disease Referral Hospital." Antibiotics 11, no. 3 (March 16, 2022): 398. http://dx.doi.org/10.3390/antibiotics11030398.
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Pulmonary thromboembolism (PTE) has been associated with tuberculosis (TB), but the true incidence is unknown. The aim of our study was to retrospectively evaluate the PTE prevalence in TB patients hospitalized at the National Institute for Infectious Diseases L. Spallanzani during the January 2016–December 2021 period. Retrospective data collection and evaluation were conducted. Among 1801 TB patients, 29 (1.61%) exhibited PTE. Twenty (69%) had comorbidities; eleven (37.9%) had predisposing factors for PTE. Nineteen (65.5%) had extensive TB disease. The commonest respiratory symptoms were cough (37.9%), dyspnea (31%), chest pain (10.3%), and hemoptysis (6.9%). Twenty-five (86.2%) had elevated serum D-dimer levels. An increased prevalence of PTE from 0.6% in the pre-COVID-19 pandemic period to 4.6% in the pandemic period was found. Acute respiratory failure and extensive TB disease increased significantly in the pandemic period. The increase in PTE could be explained by the increased severity of TB in patients in the pandemic period and by increased clinical suspicion and, consequently, increased requests for D-dimer testing, including in patients with non-COVID-19 pneumonia. Patients with extensive pulmonary disease are at high risk of developing PTE. Clinicians should be aware of this potentially life-threatening complication of TB, and patients should receive a thromboembolism risk assessment.
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Lightowler, Helen J., and G. Jill Davies. "Iodine intake and iodine deficiency in vegans as assessed by the duplicate-portion technique and urinary iodine excretion." British Journal of Nutrition 80, no. 6 (December 1998): 529–35. http://dx.doi.org/10.1017/s0007114598001627.
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I intake and I deficiency were investigated in thirty vegans (eleven males and nineteen females) consuming their habitual diet. I intake was estimated using the chemical analysis of 4 d weighed duplicate diet collections. The probability of I-deficiency disorders (IDD) was judged from the measurement of urinary I excretion in 24 h urine specimens during the 4 d. There was wide variation in I intake. Mean I intake in males was lower than the reference nutrient intake (RNI; Department of Health, 1991) and mean intake in females was above the RNI, although 36% males and 63% females had I intakes below the lower RNI. Mean I intake in subjects who consumed seaweed (n 3) was in excess of the RNI, and approached the provisional maximum tolerable daily intake (World Health Organization/Food and Agriculture Organization Joint Expert Committee on Food Additives, 1989). The probability of IDD in the group investigated was moderate to severe: three of five subgroups were classified as moderate and two subgroups were classified as severe IDD possibility. The findings highlight that vegans are an ‘at risk’ group for I deficiency. The I status of vegans and the subclinical effects of low I intakes and infrequent high I intakes on thyroid function in this group should be further studied. Our work has also raised the question of adequate I intakes in groups where cow's milk is not consumed, and has exposed a need for more research in this area.
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Bauer, Brigitte L. M. "Multiplication, addition, and subtraction in numerals: formal variation in Latin’s decads+ from an Indo-European perspective." Journal of Latin Linguistics 22, no. 1 (May 1, 2023): 1–56. http://dx.doi.org/10.1515/joll-2023-2001.
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Abstract While formal variation in Latin’s numerals is generally acknowledged, little is known about (relative) incidence, distribution, context, or linguistic productivity. Addressing this lacuna, this article examines “decads+” in Latin, which convey the numbers between the full decads: the teens (‘eleven’ through ‘nineteen’) as well as the numerals between the higher decads starting at ‘twenty-one’ through ‘ninety-nine’. Latin’s decads+ are compounds and prone to variation. The data, which are drawn from a variety of sources, reveal (a) substantial formal variation in Latin, both internally and typologically; (b) co-existence of several types of formation; (c) productivity of potential borrowings; (d) resilience of early formations; (e) patterns in structure and incidence that anticipate the Romance numerals; and (f) historical trends. From a typological and general linguistic perspective as well, Latin’s decads+ are most relevant because their formal variation involves sequence, connector, and arithmetical operations and because their historical depth shows a gradual shift away from widespread formal variation, eventually resulting in the relatively rigid system found in Romance. Moreover, the combined system attested in decads+ in Latin – based on a combination of inherited, innovative and borrowed patterns and reflecting different stages of development – presents a number of typological inconsistencies that require further assessment.
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Bell, Lucinda K., Gilly A. Hendrie, Jo Hartley, and Rebecca K. Golley. "Impact of a nutrition award scheme on the food and nutrient intakes of 2- to 4-year-olds attending long day care." Public Health Nutrition 18, no. 14 (January 28, 2015): 2634–42. http://dx.doi.org/10.1017/s1368980014003127.
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AbstractObjectiveEarly childhood settings are promising avenues to intervene to improve children’s nutrition. Previous research has shown that a nutrition award scheme, Start Right – Eat Right (SRER), improves long day care centre policies, menus and eating environments. Whether this translates into improvements in children’s dietary intake is unknown. The present study aimed to determine whether SRER improves children’s food and nutrient intakes.DesignPre–post cohort study.SettingTwenty long day care centres in metropolitan Adelaide, South Australia, Australia.SubjectsChildren aged 2–4 years (n 236 at baseline, n 232 at follow-up).MethodsDietary intake (morning tea, lunch, afternoon tea) was assessed pre- and post-SRER implementation using the plate wastage method. Centre nutrition policies, menus and environments were evaluated as measures of intervention fidelity. Comparisons between baseline and follow-up were made using t tests.ResultsAt follow-up, 80 % of centres were fully compliant with the SRER award criteria, indicating high scheme implementation and adoption. Intake increased for all core food groups (range: 0·2–0·4 servings/d, P<0·001) except for vegetable intake. Energy intake increased and improvements in intakes of eleven out of the nineteen nutrients evaluated were observed.ConclusionsSRER is effective in improving children’s food and nutrient intakes at a critical time point when dietary habits and preferences are established and can inform future public health nutrition interventions in this setting.
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Bailey, H., J. Kolesar, T. Fass, J. Weiss, J. Heideman, D. Alberti, and S. Morgan-Meadow. "A phase I study of LR-103 (1,24α(OH)2D2) in patients with refractory malignancies." Journal of Clinical Oncology 24, no. 18_suppl (June 20, 2006): 14608. http://dx.doi.org/10.1200/jco.2006.24.18_suppl.14608.
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14608 Background: Preclinical studies of calcitriol and vitamin D analogs demonstrate potent growth inhibition of tumor cell lines. The clinical development of calcitriol and other analogs have been hindered by hypercalcemia. 1α (OH)D2 is a Vitamin D analog which has produced objective responses in advanced androgen-independent prostate cancer patients and can be administered daily at 10mcg. LR103 is an active metabolite of 1α (OH)D2 with equivalent anti-tumor activity and significantly less calcemic effects in preclinical studies. This phase I study explores the maximal tolerated dose and toxicity of LR-103. Methods: LR-103 was administered daily beginning at a dose of 5 μg/day with a cycle length of 14 to 28 days. Dose escalation proceeded in two stages. In step A, intra-patient dose escalation (starting dose of 5mcg daily) was allowed based on degree of toxicity regardless of attribution. Step A escalation continued until 2 patients had ≥ grade 2 toxicity at a dose level. Step B is a standard, inter-patient only, dose-escalation trial (starting dose based on Step A) with cohorts of three. Dose limiting toxicity is defined as ≥ grade 3 toxicity. Results: Nineteen patients have enrolled between May and December 2005, eight to step A and eleven to step B. During step A escalation, two patients at 15 μg/day experienced severe toxicity (grade 4 hyperuricemia and grade 3 alkaline phosphatase) and two patients at 15 μg/day experienced grade 1 hypercalcemia. Hypercalciuria has been common. No hypercalcemia ≥ grade 2 has been observed. Step B enrollment continues at 30 μg/day without hypercalcemia. Conclusions: Daily administration of LR-103 has not resulted in significant hypercalcemia to date. Dose escalation continues. No significant financial relationships to disclose.
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Stephen, Alison M., H. S. Wiggins, H. N. Englyst, T. J. Cole, B. J. Wayman, and J. H. Cummings. "The effect of age, sex and level of intake of dietary fibre from wheat on large-bowel function in thirty healthy subjects." British Journal of Nutrition 56, no. 2 (September 1986): 349–61. http://dx.doi.org/10.1079/bjn19860116.
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1. To evaluate the effect of age, sex and level of intake on the colonic response to wheat fibre, thirty healthy volunteers aged 17–62 years (nineteen men, eleven women) recruited from a local industry, were divided into four groups and given a controlled diet for two 3-week periods. The diet contained white bread during one period or one of four different amounts of bran-enriched wholemeal bread during the other (30, 60, 110, 170 g/d).2. Wide variation was observed between subjects in stool weight on the basal diet and in response to wheat fibre. Stepwise regression analysis showed that the variation in stool weight was significantly related to sex (t4.0, P <0.001) but not to age, height, weight or energy:fibre intakes on the basal diet. Stool weight in men (162(SE 11) g/d) was approximately double that in women (83(SE 11) g/d). Transit time and stool weight were closely related and the effect of sex on stool weight could be explained entirely by differences in transit.4. Faecal carbohydrate excretion increased with the addition of bran mainly due to increased amounts of cellulose and pentose (arabinose+xylose), whilst digestibility of dietary non-starch polysaccharide fell from 77.6 (SE 2.3)% on the white bread diet to 65.6 (SE 2.4)% with the added bran (t 7.4, P < 0.01, n26).5. Faecal pH was more acid in men than in women and was related to methane production. Methane producers had higher faecal pH than non-producers (7.06 (SE 0.1 1) v. 6.65 (SE O.1)), lower stool weight (g/d; 93 (SE 12) v. 156 (SE 13)) and slower transit times (h; 84.6 (SE 11.7) v. 48.6 (SE 6.6)).6. These studies show that, when on similar diets, women have much lower stool weights and slower transit times than men. Furthermore, within the range of amounts of wheat fibre used in this and other published work, stool weight increases in linear proportion to the dose of fibre added to the diet. Methane excretion in breath is associated in this group of subjects with slow transit time and high faecal pH.
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Jo, Ki Hun, So Yeon Lee, Jae Hwan Kwon, and Jooyeon Kim. "Sequential Assessment of External Nasal Deviation Angle Changes in Patients With a Deviated Nose Who Underwent Bilateral Osteotomy." Journal of Craniofacial Surgery 35, no. 4 (June 2024): 1231–35. http://dx.doi.org/10.1097/scs.0000000000010262.
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Objective: A deviated nose is traditionally classified as bony, cartilaginous, or combined deviation. Osteotomy is commonly used to correct bony deviation, and accurate surgical techniques and postoperative patient management are important for favorable outcomes. The authors investigated the change in the external nasal deviation angle over time using sequential clinical photographs to identify the optimal postoperative follow-up duration. Methods: Medical records and sequential standardized clinical photographs of 22 patients who underwent bilateral medial and lateral osteotomies without dorsal augmentation from January 1, 2014 to May 31, 2021, were retrospectively reviewed. Clinical photographs were classified into 4 periods: “a” preoperative, “b” postoperative day (POD) ≤3 weeks, “c” POD ≤9 weeks, and “d” POD >9 weeks. The angle of deviation (AoD) was measured in both frontal and chin-on-chest views for each period. Differences in AoD between temporally adjacent periods were analyzed. Results: Nineteen men and 3 women (mean age: 28.8 y) were included. Thirteen patients showed rightward deviation, whereas 9 showed leftward deviation. Eleven patients underwent surgery through an endonasal approach, whereas the other 11 underwent surgery through an external approach. In the frontal view, AoD differences (mean ± SD) between periods “a” and “b,” “b” and “c,” and “c” and “d” were 5.79 ± 3.36 degrees (P < 0.001), 1.44 ± 1.14 degrees (P < 0.001), and 1.07 ± 1.24 degrees (P < 0.05), respectively. In the chin-on-chest view, the values were 5.17 ± 2.69 degrees (P < 0.001), 2.06 ± 2.63 degrees (P < 0.001), and 1.46 ± 1.31 degrees (P < 0.001), respectively. No statistically significant difference in AoD differences was observed between the two approaches. Conclusions: Angle of deviation can change even 9 weeks after bilateral osteotomy. Thus, long-term follow-up using sequential clinical photographs is mandatory. If needed, close follow-up with early postoperative interventions may be required. The chin-on-chest view showed better sensitivity for assessing AoD than the frontal view.
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Creemers, G. J., G. Bolis, M. Gore, G. Scarfone, A. J. Lacave, J. P. Guastalla, R. Despax, et al. "Topotecan, an active drug in the second-line treatment of epithelial ovarian cancer: results of a large European phase II study." Journal of Clinical Oncology 14, no. 12 (December 1996): 3056–61. http://dx.doi.org/10.1200/jco.1996.14.12.3056.
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PURPOSE Topotecan is a topoisomerase I inhibitor with preclinical activity against various tumor types. We conducted a large multicenter phase II study with topotecan in ovarian cancer in patients who had failed to respond to one prior cisplatin-based chemotherapeutic regimen. PATIENTS AND METHODS Topotecan 1.5 mg/m2/d was administered intravenously by 30-minute infusion for 5 days repeated every 3 weeks. As the cisplatin-free interval relates to response in subsequent treatment, patients were stratified in subgroups, ie, cisplatin-refractory, cisplatin-resistant, and cisplatin-sensitive. RESULTS One-hundred eleven patients entered the study. Nineteen patients were considered to be ineligible; 92 patients were assessable for response. A total of 552 courses were given (median, four per patient; range, one to 17). The major toxicities were leukocytopenia and neutropenia, which were grade 3 to 4 in 54.2% and 69.1% of courses, respectively, but with only 4.3% of these being grade 4 neutropenia plus fever or infectious complications. Prophylactic granulocyte colony-stimulating factor (G-CSF) was given in 20.5% of courses to maintain dose-intensity. Other relatively frequent side effects were alopecia (82%), nausea (36.4%), and vomiting (17.5%). The overall response rate was 16.3%, with one complete response (CR) and 14 partial responses (PRs). In the cisplatin-refractory, cisplatin-resistant, and cisplatin-sensitive strata, the response rates were 5.9%, 17.8%, and 26.7%, respectively. The median duration of time of documented response was 21.7 weeks (range, 4.6 to 41.9). CONCLUSION Topotecan in a daily-times-five schedule is an effective regimen as second-line treatment in ovarian cancer. Further investigations of topotecan in ovarian cancer, including first-line use and combination with other active agents, are indicated.
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GIBBS, JASON. "Revision of the metallic species of Lasioglossum (Dialictus) in Canada (Hymenoptera, Halictidae, Halictini)." Zootaxa 2591, no. 1 (August 31, 2010): 1. http://dx.doi.org/10.11646/zootaxa.2591.1.1.
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The bee subgenus Dialictus (Hymenoptera: Halictidae: Lasioglossum) comprises the most commonly collected bees in North America and have the most diverse social systems of any equivalent group of insects. Despite their importance, as pollinators and as model organisms for studying the evolution of social behaviour, Dialictus remain one of the greatest challenges in bee taxonomy. A taxonomic revision of the metallic species of Canadian Dialictus has been completed which resolves many of the difficulties of these bees. Complete species descriptions with illustrations are provided for 84 metallic Dialictus in Canada along with keys to identify males and females. The following nineteen new species are described: Lasioglossum (Dialictus) abundipunctum new species, L. (D.) atwoodi new species, L. (D.) dashwoodi new species, L. (D.) ebmerellum new species, L. (D.) ephialtum new species, L. (D.) imbrex new species, L. (D.) knereri new species, L. (D.) lilliputense new species, L. (D.) macroprosopum new species, L. (D.) packeri new species, L. (D.) prasinogaster new species, L. (D.) reasbeckae new species, L. (D.) sablense new species, L. (D.) sandhousiellum new species, L. (D.) sheffieldi new species, L. (D.) sitocleptum new species, L. (D.) taylorae new species, L. (D.) timothyi new species, and L. (D.) yukonae Gibbs, new species. Lasioglossum (D.) mitchelli is proposed as a replacement name for L. atlanticum (Mitchell) due to secondary homonymy with Halictus interruptus atlanticus Cockerell, a junior subjective synonym of L. interruptum (Panzer).The following forty-three new synonymies are proposed: L. (D.) admirandum (Sandhouse) (= D. perspicuus Knerer and Atwood); L. (D.) albipenne (Robertson) (= Halictus palustris Robertson, = H. (Chloralictus) lactineus Sandhouse, = H. (C.) basilicus Sandhouse); L. (D.) albohirtum (Crawford) (= H. pilosellus Cockerell); L. (D.) brunneiventre (Crawford) (= H. pilosicaudus Cockerell); L. cattellae (Ellis) (=D. alternatus Mitchell); L. connexum (Cresson) (= H. (C.) politissi-mus Cockerell); L. (D.) cressonii (Robertson) (= D. delectatus Mitchell); L. floridanum (Robertson) (= D. intrepidus Mitchell); L. (D.) foveolatum (Robertson) (= D. supraclypeatus Mitchell); L. (D.) imitatum (Smith) (= H. (C.) insolitus Sandhouse, = D. lectus Mitchell); L. (D.) incompletum (Crawford) (= D. ornduffi Hurd); L. (D.) laevissimum (Smith) (= H. (C.) astutus Sandhouse, = H. (C.) abundus Sandhouse, = H. (C.) jamesae Cockerell, = H. (C.) phaceliarum Cockerell, = H. (C.) praepes Sandhouse, = D. solidaginis Mitchell, = H. (C.) tranquillus Sandhouse); L. (D.) lineatulum (Crawford) (= H. (C.) latus Sandhouse); L. (D.) nigroviride (Graenicher) (= H. (C.) richardsoni Cockerell); L. (D.) obscurum (Robertson) (= D. orbitatus Mitchell); L. (D.) occidentale (Crawford) (= D. theodori Crawford); L. (D). oceanicum (Cockerell) (= D. advertus Mitchell); L. (D.) pavoninum (Ellis) (= H. (C.) evestigatus Sandhouse, = H. (C.) pikei Sandhouse, = H. (C.) abietum Michener); L. (D.) perpunctatum (Ellis) (= D. highlandicus Mitchell, = D. junaluskensis Mitchell); L. (D.) sagax (Sandhouse) (= Halictus (C.) accentus Sandhouse); L. (D.) semibrunneum (Cockerell) (= Halictus oleosus Cockerell); L. (D.) semicaeruleum (Cockerell) (= H. pruinosiformis Crawford, = H. (C.) actuarius Sandhouse); L. (D.) subversans (Mitchell) (= D. perpunctatulus Knerer and Atwood); L. (D.) tenax (Sandhouse) (= H. (C.) meritus Sandhouse, = D. disabanci Knerer and Atwood); L. (D.) versans (Lovell) (= H. (C.) brevibasis Cockerell); L. (D.) versatum (Robertson) (= H. (C.) apertus Sandhouse, = H. (C.) genuinus Sandhouse, = H. subconnexus rohweri Ellis); L. (D.) zephyrum (Smith) (= H. (C.) academicus Sandhouse). Halictus (C.) unicus Sandhouse is again treated as a junior synonym of L. lineatulum. Eleven subgeneric names recently proposed by Pesenko are treated as synonymies of Dialictus. Some species names are used here in a sense different from those of most previous authors (e.g. H. nymphaearus, H. versatus). Names have often been misapplied in past usage sometimes subsuming multiple species. In some cases, even paratypes do not correspond to the same species as the name bearing type. The following three species are resurrected from synonymy: L. (D.) leucocomum (Lovell) new combinaton, L. (D.) oceanicum (Cockerell) new combination, and L. (D.) planatum. The species L. (D.) atriventre (Crawford) is considered a nomen dubium. The following twelve new records for Canada are reported: L. (D.) achilleae (Mitchell), L. (D.) brunneiventre (Crawford), L. (D.) callidum (Sandhouse), L. (D.) incompletum (Crawford), L. (D.) hudsoniellum (Cockerell), L. (D.) marinense (Michener), L. (D.) pacatum (Sandhouse), L. (D.) pallidellum (Ellis), L. (D.) punctatoventre (Crawford), L. (D). sagax (Sandhouse), L. (D.) weemsi (Mitchell) and L. (D.) zophops (Ellis). The Canadian records of two species, L. (D.) disparile (Cresson) and L. (D.) ceanothi (Mitchell), do not seem reliable and these species are not included in the revision. Two species, L. testaceum (Robertson) and L. rufulipes (Cockerell), are transferred from the L. (Dialictus) to L. (Evylaeus) sensu stricto.
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Soverini, Simona, Giovanni Martinelli, Gianantonio Rosti, Simona Bassi, Marilina Amabile, Angela Poerio, Barbara Giannini5, et al. "ABL Mutations in Late-Chronic Phase Chronic Myeloid Leukemia Patients with Cytogenetic Refractoriness to Imatinib Are Associated with a Greater Likelihood of Progression to Blast Crisis and Shorter Survival. on behalf of the GIMEMA Working Party on Chronic Myeloid Leukemia." Blood 104, no. 11 (November 16, 2004): 1005. http://dx.doi.org/10.1182/blood.v104.11.1005.1005.
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Abstract Using a novel denaturing-high performance liquid chromatography (D-HPLC)-based screening method, we investigated the frequency and prognostic relevance of ABL mutations in 47 CML patients who never achieved a major cytogenetic response in 12 months of Imatinib therapy. Seven patients were enrolled in the CML/011/STI571 trial (early-CP patients treated with Imatinib 400 mg/d and peghilated-interferon) while the remaining 40 were enrolled in the CML/002/STI571 trial (late-CP patients resistant/refractory to α-interferon, treated with Imatinib 400 mg/d). For each patient, a longitudinal analysis was done on all the available samples collected from Imatinib start up to the twelfth month of therapy. A nested RT-PCR was set up and, for each sample, two fragments of 393 and 482 bp spanning the ABL kinase domain were analysed. Two out of 7 (29%) early-CP patients had mutations, resulting in both cases in novel aminoacid substitutions (F311I, E355D). Mutations were already detectable at 6 and 9 months, respectively, from Imatinib start. Nineteen out of 40 (48%) late-CP patients had mutations. Eleven patients showed mutations falling in close proximity (M244V) or within (G250E, Y253F, Y253H, E255K, E255V) the P-loop. Eight patients showed mutations outside the P-loop (F311L, F317L, M351, E355G, F359V, H396R and a silent mutation at codon 298). Mutations were already detectable after a median of 3 months (range, 1–6) from onset therapy. At the time of mutation detection, all patients but four had sustained hematologic response. Presence of a missense mutation was significantly associated with a greater likelihood of subsequent progression to accelerated phase/blast crisis (AP/BC)(P=0.0002) and shorter survival (P=0.001). Patients with mutations falling in close proximity or within the P-loop had a particularly poor outcome in terms of time to progression to AP/BC with respect to the remaining mutated patients (P=0.03). Our results indicate that: i) ABL kinase domain mutations may be found also in the setting of early-CP CML patients, even though they are not the predominant mechanisms of resistance; ii) as many as 50% of late-CP patients who fail to achieve cytogenetic control of the disease in the first 6 months of therapy already have evidence of a mutation by D-HPLC analysis; iii) within cytogenetic nonresponders, presence of ABL mutations may identify a subset of patients with particularly poor prognosis. Thus, irrespective of the hematologic response, regular monitoring for emerging mutations in the first months of Imatinib administration may play a crucial role in detecting patients for whom a revision of the therapeutic strategy should be considered.
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Fedynich, Alan M., William C. Colson, David G. Hewitt, Shelly R. Kremer, and Corey D. Mason. "Pilot Study for Aging Classification Criteria of Fledged Juvenile Eastern White-winged Doves." Journal of Fish and Wildlife Management 4, no. 2 (August 1, 2013): 290–97. http://dx.doi.org/10.3996/062012-jfwm-050.
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Abstract Nineteen eastern white-winged doves Zenaida asiatica asiatica were hatched and raised in captivity and used to develop an aging key that 1) quickly identifies juveniles based on a series of morphological features, and 2) provides estimates of juvenile age based on primary feather replacement. Birds were photographed every three days from 17 to 170 d posthatch to determine sequence of primary flight feather replacement; persistence of juvenile secondary coverts; and development of blue eye ring, black neck bars, and leg color. Eleven birds exhibited adult features such as absence of buffy-tipped primary coverts, blue eye-ring color, complete black neck bar, and red leg color at day 170 posthatch; two birds had these features as early as day 122. Replacement of primary feathers was variable among individuals beyond day 35 beginning with the third primary. Primary feather (primary notation P1–P10) replacement occurred gradually. By day 170, 2 of 17 birds had replaced all primary feathers, 3 birds had fully molted P9 but not P10, 8 birds had begun molting P9 but not P10, and 4 birds did not molt either P9 or P10. Increased variability in primary feather replacement occurred as juveniles progressed toward adulthood; this precluded accurate age estimates of older juveniles based exclusively on primary replacement. The present study provides a better understanding of the molting process that wildlife managers, biologists, and researchers can use at hunter check stations or during trapping and banding operations to separate age classes, which is necessary to establish hunting frameworks and to assess the population effects of harvest and other mortality factors. This pilot study provides the foundation needed for further investigations into developmental patterns of fledged juvenile white-winged doves and provides an aging key that represents an improvement over previous white-winged dove aging keys or reliance on aging keys of closely related species.
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Ji, Jie, Tian Dong, Pu Kuang, Zhigang Liu, Jiazhuo Liu, Li Zhang, Ting Niu, and Ting Liu. "Chidamide-Containing Conditioning Allogenic Hematopoietic Stem Cell Transplantation Improves Prognosis of Acute Lymphoblastic Leukemia with Pre-Transplant Response Less Than Complete Remission." Blood 132, Supplement 1 (November 29, 2018): 3366. http://dx.doi.org/10.1182/blood-2018-99-114763.
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Abstract Background: Allogeneic hematopoietic stem cell transplantation (HSCT) is a curative option currently offered to patients with high-risk or relapsed acute lymphoblastic leukemia (ALL). However, active disease or minimal residual disease (MRD) prior to HSCT is associated with early relapse and poor prognosis with long-term survival less than 30%. We have confirmed that chidamide, a selective histone deacetylase inhibitor (HDACi), work synergistically with cytotoxic agents such as combination of cladribine, gemcitabine and busulfan as conditioning therapy against lymphocytic malignancies. Here, we conducted a clinical trial to evaluate the efficacy of chidamide containing conditioning allo-HSCT in patients with these high-risk ALLs. Methods: Patients with active ALL or MRD received a myeloablative conditioning consisting of chidamide, fludarabine, cytarabine and busulfan (ChiFAB), followed by infusion of peripheral blood hematopoietic stem cells from related or unrelated donors. The ChiFAB was administered as following: chidamide was given orally at 20 mg twice weekly started from D-7 for 3 weeks; fludarabine was given intravenously at 30 mg/m2 D-6 to D-2; cytarabine was given 4 hours after the finish of fludarabine at 1 g/m2 D-6 to D-2; and busulfan was given intravenously once daily at 3.2 mg/kg D-6 to -3. Prophylaxis of acute graft-versus-host-disease were posttransplant cyclophosphamide plus cyclosporine for matched donor transplants, and additional post-transplant anti-thymocyte globulin and mycophenolate mofetil for haplo-HSCT. Donor lymphocyte infusion was not routinely administered in this trial. Results: Twenty-four patients were enrolled with median age of 24.5 (16-61 years). Male to female ratio was 3:1. Six (25%) had a diagnosis of Philadelphia positive acute B cell lymphoblastic leukemia (Ph+B-ALL), 8 (33.3%) had Ph-B-ALL, and 10 (41.7%) had T-ALL. Nineteen (79.2%) patients were MRD positive (blast cells <5% in the bone marrow), while five (20.8%) were with active disease (blast cells ≥5%). Eleven (45.8%) patients underwent matched sibling donor transplant, 4 (16.7%) underwent matched unrelated donor transplant, and 9 (37.5%) received haplo-HSCT. Neutrophils and platelets engrafted at a median of 14 days (12-20 days) and 16 days (12-46 days) post-transplant, respectively. Twenty (83.3%) patients reached MRD negative at 30 days. The median follow-up time of the whole cohort was 9.2 months (2-43.8), estimated 1-year progression free survival (PFS) and overall survival (OS) are 53.1% and 59.4% (Figure-1 A&B). For patients with MRD or active disease, estimated 1-year PFS are 67% and 0% (Figure-1 C), and estimated 1-year OS of these 2 groups of patients are 67.7% and 30% (Figure-1D), respectively. Only one patient (4.2%) developed II° aGvHD within 100 days post-transplant (Figure-1 E). The incidence of non-relapse mortality is 24.6% (Figure -1 F). Conclusions: Chidamide-containing conditioning allo-HSCT may improve the prognosis of ALL with MRD. Figure 1. Figure 1. Disclosures Liu: West China Hospital of Sichuan University: Employment.
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IIJIMA, KAZUMOTO, KIYOSHI HAMAHIRA, AKIKO KOBAYASHI, HAJIME NAKAMURA, and NORISHIGE YOSHIKAWA. "Immunohistochemical Analysis of Renin Activity in Chronic Cyclosporine Nephropathy in Childhood Nephrotic Syndrome." Journal of the American Society of Nephrology 11, no. 12 (December 2000): 2265–71. http://dx.doi.org/10.1681/asn.v11122265.
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Abstract. Although the pivotal role of activation of the intrarenal renin-angiotensin system (RAS) has been demonstrated in the rat model of chronic cyclosporine (CyA) nephropathy, it is still unclear whether intrarenal RAS activation is responsible for chronic CyA nephropathy in humans. Therefore, the distribution of renin in formalin-fixed, paraffin-embedded renal biopsy specimens obtained from 26 children who had idiopathic nephrotic syndrome (NS) and who were treated with long-term moderate-dose CyA was examined with the use of immunohistochemistry with rabbit polyclonal anti-human renin antibody. Nineteen patients had steroid-dependent NS, and 7 had steroid-resistant NS. However, CyA treatment led all of the latter patients into complete remission. All of the patients underwent renal biopsies at the start and the end of CyA treatment. In the pre-CyA specimens, immunoreactivity to renin was detected mainly in those parts of arterioles within the anatomically well-defined juxtaglomerular apparatus. In the post-CyA specimens, it was also detected in those parts of the vessels upstream from the juxtaglomerular apparatus. Moreover, the ratio of the number of renin-positive cells to the number of glomeruli (histologic renin index) increased significantly with long-term CyA treatment (from 1.26 ± 0.24 to 4.30 ± 0.40, P < 0.0001). Eleven of the post-CyA specimens showed mild or moderate CyA-associated arteriolopathy (CAA), whereas 15 showed no CAA. The histologic renin index was significantly higher in specimens with CAA than in those without CAA (5.16 ± 0.59 versus 3.67 ± 0.48, P = 0.031). Seven CAA-positive patients underwent repeat biopsies 6 to 12 mo after discontinuing the CyA. Their specimens showed an improvement in the CAA and significantly lower histologic renin index compared with the post-CyA (from 4.18 ± 0.69 to 2.10 ± 0.25, P = 0.018). Eleven of the post-CyA specimens showed mild to moderate interstitial fibrosis, and 15 showed no fibrosis. There was no significant difference in immunoreactivity to renin between the specimens with interstitial fibrosis and those without. However, patients with interstitial fibrosis had significantly longer periods of heavy proteinuria during CyA therapy, because of either steroid-resistant NS or frequent relapses of NS (83 ± 18 versus 35 ± 12 d, P = 0.030). These findings indicate that long-term CyA treatment for idiopathic NS in children may stimulate renin production in arterioles. They also suggest that CyA-stimulated intrarenal RAS activation is responsible for the development of CAA and that CyA-induced interstitial fibrosis is potentiated by long-term heavy proteinuria and is at least partly independent of CyA-stimulated intrarenal RAS activation.
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Pérez-Alvarez, Lucía, Rocío Carmona, Mercedes Muñoz, Elena Delgado, Michael M. Thomson, Gerardo Contreras, José D. Pedreira, et al. "High Incidence of Non-B and Recombinant HIV-1 Strains in Newly Diagnosed Patients in Galicia, Spain: Study of Genotypic Resistance." Antiviral Therapy 8, no. 4 (May 1, 2002): 355–60. http://dx.doi.org/10.1177/135965350300800413.
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The objectives of this study are to describe the incidence of non-B and recombinant HIV-1 strains in newly diagnosed HIV-1 infections in Galicia, northwest of Spain, during a 2-year period (May 2000 to June 2002), and the frequency of resistance-associated mutations in reverse transcriptase (RT) and protease (PR) genes, analysing the polymorphisms more frequently detected in non-B and recombinant viruses. All newly diagnosed HIV-1-infected patients attending the nine public hospitals of the seven main cities of Galicia were included in this study. RT, PR and V3 regions from HIV-1 RNA plasma were amplified and sequenced, being the corrected sequences sent to the Stanford HIV RT and Protease Sequence Database. Nineteen of 85 patients (22.3%) were infected by non-B or recombinant viruses: three subtype C, two G, one F1, one Dpol/A1V3, five CRF02_AG, one CRF14_BG, five BGpol/BV3 and one UKpol/UV3 (U, unknown fragment). Eleven of these 19 patients (57.9%) were foreign individuals living in Galicia infected through heterosexual contact, and the other eight (42.1%) were Spanish intravenous drug users who had shared injection equipment. Five of 85 patients (5.9%), all infected with B subtype viruses, showed resistance-associated mutations in RT (M184V, M41L, L210W, T215Y/D and K219Q). In one patient (1.2%) infected with a subtype G strain, resistance-associated mutations in PR (K20I+M36I+M46I+V82I) were detected. In subtype B viruses resistance mutations in PR were not detected. Several polymorphisms in RT: D123S, Q174K, D177E, T200A, V245Q, and PR: I13V, K20I, M36I, R41K, H69K, L89M were detected more frequently in non-B and recombinants than in B strains ( P<0.01 to P<0.001). This study reports a high incidence (22.3%) of newly diagnosed patients infected by different non-B and recombinant HIV-1 strains, in a geographical area of Spain, showing also a high frequency of polymorphisms in RT and PR genes.
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Yang, Wenrui, Bing Han, Hong Chang, Bingyi Wu, Fankai Meng, Dexiang Ji, Yingmei Li, et al. "Real-World Effectiveness and Safety of Eltrombopag in Patients with Aplastic Anemia: A Chinese Nationwide Survey." Blood 134, Supplement_1 (November 13, 2019): 5020. http://dx.doi.org/10.1182/blood-2019-126441.
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Immunosuppressive therapy (IST) based on antithymoglobin (ATG) and cyclosporin (CsA) is the first-line treatment for severe aplastic anemia (SAA) patients who are unfit for transplantation,and the overall response rate (ORR) is about 70%.The utility of eltrombopag (EPAG),a TPO receptor agonist, achieved robust hematologic response in refractory and treatment-naïve SAA patients in clinical trials and some other studies. However, only a few data came from Asia countries where higher incidence of AA has been reported. A retrospective study on the use of EPAG in AA was conducted in mainland China. Aplastic anemia (transfusion dependent non-severe, severe, and very severe) patients who started eltrombopag before Feb 2019 and continued for at least 3 months either as first-line treatment or as rescue treatment, were enrolled. The maximum daily dosage of EPAG used continuously for at least 2 weeks is defined as the stable dosage. Response criteria were referred to that used in previous reports (Townsley DM, NEJM 2017; BCSH, BJH 2016). Fifty-six patients from eleven centers were enrolled in this study, including 26 males and 30 females at the median age of 39 (7-80) years. All patients were transfusion-dependent by the time of EPAG administration, and there were 14 VSAA, 24 SAA and 18 transfusion dependent non-severe aplastic anemia (TD-NSAA). Nineteen treatment-naïve patients received EPAG and IST (ATG+CsA, n=10; CsA/CsA+androgen, n=9) as first-line treatment. Thirty-seven patients were refractory to IST. Eltrombopag was administered at a median dose of 75 (25-150) mg per day for 7 (3-31) month. The median follow-up time was 9 (3-40) months. The overall response rate in patients receiving EPAG as first-line therapy was 78.9% (15/19), and most patients achieved complete response (CR) (10/15). Among the 10 patients receiving ATG+CsA, 6 patients achieved hematologic response (HR) at 3 months post-treatment, including 3 CR. Six patients were diagnosed as VSAA and three achieved HR. For the 9 patients treated with CsA/CsA+androgen, 8 achieved HR (88.9%) and 4 were CR (44.4%) at 3 months. By last follow-up, the cumulative HR rate was 70% in ATG+CsA group and 89% in CsA/CsA+ androgen group. Among the 14 responders, 11 patients receiving EPAG at a stable dosage ≤75mg/d and achieved HR at 3 months. The overall response rate in IST-refractory patients was 46% (17/37), with trilineage response in 27% patients at 3 months. For the 18 ATG+CsA refractory SAA patients,trilineage HR occurred in 4 patients (22.2%, 4/18), bi-lineage HR in one patient and single lineage HR in one patient. Thus, the total HR was 33.3% (6/18) at 3 months and increased to 44% (8/18) by last follow-up. Among the 19 CsA/CsA+ androgen refractory patients, 6 (31.5%, 6/19) achieved trilineage HR, one achieved bi-lineage HR and 4 achieved single lineage response. Total HR rate was 57.9% (11/19) at 3 months after EPAG initiation and 68% (13/19) by last follow-up, including 9 patients with trilineage HR. Among 17 responders, 13 received a stable EPAG dose of≤75mg/d. Most patients tolerated EPAG well. Adverse events occurred in 29 patients (52%) and most were mild to moderate, including gastrointestinal symptom (n=15, e.g. abdominal pain, nausea), impaired liver function (n=5), skin changes (n=7, e.g. skin pruritus and rash) and musculoskeletal pain (n=6), and venous thrombus (n=2). Eltrombopag dosage was reduced in 2 patients due to severe digestive symptoms at 100 mg/d and discontinued in one patient who suffered from upper limb venous thrombus. In conclusion, EPAG is effective and safe in treating Chinese AA patients at a daily dose of 75mg and less. The real-world result of EPAG in Chinese patients is similar to those reported in Western countries. Disclosures No relevant conflicts of interest to declare.
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Cabrera, Cristina Calderón, Jose F. Falantes, Marina Gómez, Rocío Parody, Francisco J. Márquez Malaver, María L. Martino, José González, Isabel Montero, Ildefonso Espigado, and Jose Antonio Pérez-Simón. "Azacitidine Alone Or The Combination With Valproic Acid As a Bridge Therapy For Acute Myeloid Leukemia and Higher-Risk Myelodysplastic Syndromes Before Transplantation." Blood 122, no. 21 (November 15, 2013): 2812. http://dx.doi.org/10.1182/blood.v122.21.2812.2812.
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Abstract Introduction Intensive chemotherapy (IC) followed by allogeneic stem cell transplantation (AlloSCT) is standard of care for intermediate and high-risk acute myeloid leukemia (AML) and high-risk myelodysplastic syndromes (MDS). However, morbidity and lack of response are common with IC. Retrospective data have shown similar outcomes with azacitidine (AZA) when compared to IC. Moreover, the combination of AZA with other epigenetic modifiers such as HDAC inhibitors seems to improve quality of responses. Aim Evaluate response, toxicity and feasibility of AlloSCT after AZA alone or the combination with valproic acid (VPA) as a bridge strategy in MDS and AML. Patients Nineteen consecutive patients (pts) receiving azacitidine alone (n=11) or in combination with valproic acid (VPA) (n=8) were analyzed. Median age of the cohort was 57 years (18-67). Diagnosis by WHO classification included: RAEB-2 (n=10/19; 52.6%), RAEB-1 (n=2; 10.5%), RCMD (n=2; 10.5%) and AML (n=5; 26.3%). Four out of 5 AML pts had bone marrow blast count >30% at diagnosis. In MDS patients, according to International Prognostic Scoring System (IPSS): 1 intermediate-1 (7%), 3 intermediate-2 (21.5%) and 10 high-risk (71.5%) and by IPSS-revised (IPSS-R): 1 intermediate (7%), 4 high (29%) and 9 very high (64%). Regarding karyotype, in MDS: 5 good (35.7%), 2 intermediate (14.3%), 6 poor (43%) and 1 insufficient metaphases (7%) whereas in AML Patients 1 intermediate (20%) and 4 adverse (80%). Eleven out of 19 pts (58%) received AZA as frontline therapy. The remaining 8 pts experienced disease relapse after intensive chemotherapy (IC) or had primary refractory AML, and subsequently received AZA plus VPA as salvage therapy. Median courses of previous IC were 2 (1-4). For pts receiving AZA/VPA, median bone marrow blast % and leukocyte were 31% (2-60) and 1.9x10e9/L (0.3-4.2) when therapy started. Most of these pts had refractory or relapsed disease (n=6/8; 75%) with 4 pts displaying poor karyotype. Treatment schema was AZA (75 mg/m2, 7d/4w) and VPA (20-25 mg/kg/d, 10 days). Results At analysis, 17/19 pts are evaluable for response. Median courses of AZA: 5 (2-53). Overall response (ORR) at 4 courses: 59% (CR=4/17; 23.5%, CRm=5/17; 29.5% and PR=1/17; 6%). For pts receiving AZA/VPA (Table 1, n=8), ORR: 83% (CR=1/6; 17% and CRm=4/6, 66%) in 6 evaluable pts. Median courses to response were 2. Among pts achieving CR/CRm/PR/SD at 4 courses (n=12), 2 pts lost response prior to AlloSCT. Most frequent toxicity was hematological (58% grade 3-4) with no treatment related mortality attributable to AZA/VPA. Eleven out of 19 pts (58%) received AlloSCT (matched related=5, matched unrelated=5, haploidentical=1). Causes for not proceeding to AlloSCT: Disease progression (n=4; 50%), infection (n=1; 12.5%), pending evaluation after 2 courses (n=2; 25%) and 1 pt (12.5%) scheduled for matched unrelated AlloSCT. Conditioning regimen: Reduced intensity (9/11) and myeloablative (2/11). Tacrolimus/sirolimus (50%) and cyclosporine/MMF (40%) as GVHD prophylaxis. With a median follow-up of 4 months after AlloSCT (1-26), only 1 pt developed acute GVHD, 1 had early relapse postransplant and 9 patients continue in CR at last follow up. Conclusions AZA alone and particularly the combination AZA/VPA prior to AlloSCT is a well-tolerated and highly effective schema even in pts with poor prognostic features and refractory to prior IC. Adequate selection of pts (leukocyte <10x10e9/L) and larger prospective studies are needed to assess the role of this strategy. AML; Acute myeloid leukemia, RAEB-2; Refractory anemia with excess blasts type 2, RAEB-1; Refractory anemia with excess blasts type 1, IM; Insufficient metaphases, IC; Intensive chemotherapy, CR; Complete response, CRm; marrow CR, NA; Not assessable (pending bone marrow evaluation). 1Refractory to IC. 2Relapsed after IC. aBone marrow evaluation after 2 and 4 courses of therapy Disclosures: No relevant conflicts of interest to declare.
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Zeisig, Deniz T., Claudia B. Bittner, Bernd B. Zeisig, Maria-Paz García-Cuéllar, Jay L. Hess, and Robert K. Slany. "The eleven-nineteen-leukemia protein ENL connects nuclear MLL fusion partners with chromatin." Oncogene 24, no. 35 (April 25, 2005): 5525–32. http://dx.doi.org/10.1038/sj.onc.1208699.
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Verma, Jyoti, Prakash Nautiyal, and Prateek Srivastava. "Diatoms of the Cymbella sensu lato species of the two different eco-regions of the Indian Mountain Rivers." Annals of Plant Sciences 6, no. 10 (October 1, 2017): 1705. http://dx.doi.org/10.21746/aps.2017.6.10.4.
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This paper describes Cymbella sensu lato (Cymbopleura, Delicata, Encyonema, Encyonopsis and Reimeria) species from two different ecoregions of India. In the present study, twenty-six diatom taxa belonging to the genus Cymbella sensu lato were identified. In the flora nineteen species were recorded from the Vindhya region while eleven from the Himalaya. All of them were first records for the Vindhyan rivers. Seven taxa were new records for the Himalayan river.
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DEAN, HARLAN K., IVÁN HERNÁNDEZ-ÁVILA, and EDWARD B. CUTLER. "Sipunculans of the Caribbean coast of Venezuela and Curaçao." Zootaxa 1431, no. 1 (March 26, 2007): 45–54. http://dx.doi.org/10.11646/zootaxa.1431.1.2.
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All sipunculan species currently known to occur on the Caribbean coast of Venezuela and Curaçao are reviewed. Included are species previously reported in the primary literature and those collected by Cutler (EBC) in 1987/1988 and Hernández-Ávila (IHA) in 2003/2004. Nineteen species of sipunculans belonging to eleven genera are known from this region. Most specious is the genus Aspidosiphon with seven species and the genus Phascolosoma with three species.
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Suzuki, Atsuo, Yuhri Miyawaki, Eriko Okuyama, Moe Murata, Ando Yumi, Io Kato, Yuki Takagi, et al. "Ribavirin-Induced Intracellular GTP Depletion Upregulates Factor VII Expression." Blood 120, no. 21 (November 16, 2012): 1113. http://dx.doi.org/10.1182/blood.v120.21.1113.1113.
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Abstract Abstract 1113 In this study, we investigated the molecular basis of upregulation of factor VII (FVII) gene expression by ribavirin, and found that intracellular GTP depletion induced by ribavirin activated FVII gene transcription and modulated transcription elongation. In 2006, Yamamoto et al. reported that anti-hepatitis C virus (HCV) agent ribavirin elevated the activity of FVII in HCV-infected hemophilia patients; however, the precise mechanisms were still unknown. In addition, the anti-HCV mechanisms of ribavirin were not yet fully elucidated, although the extended studies have been done. We investigated the effects of ribavirin in vitro and confirmed the approximately 4-fold upregulation of FVII mRNA by ribavirin treatment in HepG2 cells. FVII mRNA was increased in a dose-dependent manner up to 100μg/mL of ribavirin at a lower concentration than therapeutic concentration of 150μg/mL. FVII mRNA induction by ribavirin was also observed in a time-dependent manner from 24 h to 72 h after treatment. Ribavirin metabolite ribavirin 5'-monophosphate is one of the IMP dehydrogenase (IMPDH) inhibitors, and the other IMPDH inhibitors mycophenolic acid (MPA) and 6-mercaptupurine (6-MP) also induced FVII upregulation. It is well known that inhibition of IMPDH causes intracellular GTP depletion, and guanosine supplementation to salvage GTP could reverse FVII mRNA increase in ribavirin-treated cells. These results indicated that cellular GTP reduction associated with FVII gene upregulation. The mechanisms of gene upregulation by GTP depletion were not elucidated. The promoter activities and mRNA stability of FVII were analyzed under ribavirin treatment. The FVII gene promoter activity was enhanced up to 1.5-fold by ribavirin treatment; however the activation did not reach 4-fold induction of FVII mRNA increase. There was no significant change of FVII mRNA half-life in ribavirin-treated cells. Since the promoter activation might display transcription initiation capacity, the contribution of transcription elongation stage was further investigated. Transcription elongation was regulated by phosphorylation of carbo-terminal domain (CTD) of RNA polymerase II (PolII). Transcription elongation factor P-TEFb (positive-transcription elongation factor b), which consists as a complex of CDK9 and cyclin T, phosphorylates Ser of PolII CTD. The kinase activity of P-TEFb could be inhibited by 5,6-dichlorobenzimidazole 1-b-D-ribofuranoside (DRB). In FVII gene upregulation, DRB completely canceled ribavirin-induced FVII mRNA increase. We also performed nuclear run-on assay to verify the potential transcription elongation capacity of paused PolII, and observed a dramatic increase of FVII mRNA in ribavirin-treated cells. These results suggested that ribavirin-induced FVII gene upregulation was caused not only by transcription initiation but also by accelerated transcription elongation rate. There are various transcription factor associated with transcription elongation in addition to P-TEFb, such as elongin, ELL (eleven nineteen-lysine rich leukemia). We found that ELL3, a member of ELL family protein, was upregulated by ribavirin treatment. A ELL3 mRNA increase occurred prior to FVII mRNA upregulation, and the ELL3 upregulation was also canceled by guanosine supplementation. These results indicated ELL3 induction by ribavirin was also a response to cellular GTP depletion. To confirm the contribution of ELL3 protein to FVII gene transcription elongation, we used siRNAs specific to ELL3 and as expected, knockdown of ELL3 resulted in diminished FVII upregulation. A chromatin immunoprecipitation (ChIP) revealed ELL3 recruitment to the FVII gene, and the recruitments of PolII and CDK9 were also enhanced by ribavirin treatment. Taken together, FVII gene upregulation by ribavirin was associated with intracellular GTP depletion. The GTP reduction mainly modulates transcription elongation rate rather than transcription initiation, though the relationships between cellular GTP depletion and enhanced transcription elongation must be investigated. This study uncovered candidate mechanisms of ribavirin and the other IMPDH inhibitors and highlights a development of novel pharmaceutical therapies for hemophilia. Disclosures: No relevant conflicts of interest to declare.
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Pfeifer, Heike, Barbara Wassmann, Andreas Käbisch, Michael Lübbert, Lothar Leimer, Aristoteles Giagounidis, Dieter Hoelzer, and Oliver G. Ottmann. "Imatinib and Interferon-Alpha Maintenance Therapy for Patients with Philadelphia-Positive Acute Lymphoblastic Leukemia (Ph+ALL) Ineligible for Allogeneic Stem Cell Transplantation (SCT)." Blood 114, no. 22 (November 20, 2009): 2042. http://dx.doi.org/10.1182/blood.v114.22.2042.2042.
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Abstract Abstract 2042 Poster Board II-19 Introduction: The tyrosine kinase inhibitor imatinib (IM), alone or in combination with chemotherapy, has become the mainstay of front-line treatment for Ph+ ALL. We recently demonstrated that IM in combination with intensive consolidation chemotherapy of approximately one year duration is feasible in elderly patients with de novo Ph+ ALL, but is associated with a high relapse rate. Allogeneic SCT (alloSCT) is potentially curative but may not be feasible in most elderly or comorbid patients. Maintenance therapy (MT) in such patients is conceptually attractive, but data on whether any type of MT facilitates long-term leukemia-free survival of patients with Ph+ALL in first CR is lacking. Based on data suggesting that interferon-alpha (IFN-a) possesses anti-leukemic activity in patients with Ph+ALL, we conducted a phase II study to determine the feasibility and efficacy of MT consisting of imatinib in combination with low-dose (LD) IFN-a in elderly patients with Ph+ALL who were not eligible for SCT. In addition, we examined whether bcr-abl transcript levels and mutation status were predictive of relapse and remission duration. Methods: Nineteen elderly patients (median age 66 yrs; [60-75 yrs.]) who had received IM-based remission induction and consolidation therapy as reported previously (Ottmann et al., Cancer 109:2068-76, 2007) were enrolled in a clinical trial of IM 400 mg daily in combination with LD-IFNa with a target dose of 3 Mio IU/week. At the time of enrollment, the majority of patients (n=12) had received five (n=3) or six (n=9) consolidation cycles, the remaining patients had discontinued intensive front-line therapy after four (n=2), three (n=1), two (n=1), and one (n=1) consolidation cycles, 2 patients were switched to MT after induction. The median number of cycles of consolidation chemotherapy given concurrently with IM was six. Minimal residual disease (MRD) was serially assessed by quantitative RT-PCR, mutational analyses was performed by D-HPLC and direct sequencing. Results: The median overall duration of MT is 26 mos. (range 3-92 mos.). Seven of 19 pts. (37 %) are in ongoing CR, with a median remission duration from start of maintenance of 76.7 mos. (54-91 mos.). Median overall survival of all pts. is 61 mos. (range: 20-99 mos.). Eleven of 18 evaluable pts. experienced side effects which lead to a dose reduction of IFN. 9 pts. suffered from moderate depressions or fatigue. Hematologic toxicity was mild: only 2 pts. developed grade 3 cytopenia during MT. Remission duration was independent of the number of previous cycles of intensive chemotherapy, of the MRD response during the first 6 mos. of intensive front-line therapy (16 mos. vs. 26 mos.) and of achievement of PCR negativity at any time during intial therapy. Surprisingly, the bcr-abl transcript level at the start of MT likewise had no impact on time to disease recurrence. Conclusions: In elderly Ph+ALL pts. ineligible for allogeneic SCT, maintenance with imatinib in combination with low-dose IFN-a results in long-term sustained remissions in a substantial proportion of patients, with acceptable side effects. Surprisingly, the MRD response and mutation status prior to MT were not significantly predictive of remission duration. Likewise, greater intensity of prior chemotherapy as determined by the number of administered consolidation cycles had no significant benefit with respect to remission duration during MT. More extensive evaluation of tyrosine kinase inhibitors in combination with LD IFNa as MT for Ph+ALL is warrented. Disclosures: Ottmann: Novartis: Honoraria, Membership on an entity's Board of Directors or advisory committees; BMS: Honoraria.
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Holmes, Jeremy. "A Study of Brief Psychotherapy: D. H. Malan." British Journal of Psychiatry 154, no. 06 (June 1989): 891–93. http://dx.doi.org/10.1017/s0007125000176548.
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Paraphrasing Philip Larkin (1974), it might be said that British psychotherapy research ‘began/In nineteen sixty three’ – the year of publication of A Study of Brief Psychotherapy – ‘Between the end of the Chatterly ban/And the Beatles' first LP’.
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Holmes, Jeremy. "A Study of Brief Psychotherapy: D. H. Malan." British Journal of Psychiatry 154, no. 6 (June 1989): 891–93. http://dx.doi.org/10.1192/s0007125000176548.
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Paraphrasing Philip Larkin (1974), it might be said that British psychotherapy research ‘began/In nineteen sixty three’ – the year of publication of A Study of Brief Psychotherapy – ‘Between the end of the Chatterly ban/And the Beatles' first LP’.
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Heidenreich, David, Moses Moustakim, Jurema Schmidt, Daniel Merk, Paul E. Brennan, Oleg Fedorov, Apirat Chaikuad, and Stefan Knapp. "Structure-Based Approach toward Identification of Inhibitory Fragments for Eleven-Nineteen-Leukemia Protein (ENL)." Journal of Medicinal Chemistry 61, no. 23 (November 8, 2018): 10929–34. http://dx.doi.org/10.1021/acs.jmedchem.8b01457.
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Chattopadhyay, Surajit, and Goutami Chattopadhyay. "Identification of the best hidden layer size for three-layered neural net in predicting monsoon rainfall in India." Journal of Hydroinformatics 10, no. 2 (March 1, 2008): 181–88. http://dx.doi.org/10.2166/hydro.2008.017.
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In the present research, long-range prediction of average summer monsoon rainfall over India has been attempted through three layered artificial neural network models. The study is based on the summer monsoon data pertaining to the years 1871–1999. Nineteen neural network models have been developed with variable hidden layer size. Total rainfall amounts in the summer monsoon months of a given year have been used as input and the average summer monsoon rainfall of the following year has been used as the desired output to execute a supervised backpropagation learning procedure. After a thorough training and test procedure, a neural network with eleven nodes in the hidden layer is found to be the most proficient in forecasting the average summer monsoon rainfall of a given year with the said predictors. Finally, the performance of the eleven-hidden-nodes three-layered neural network has been compared with the performance of the asymptotic regression technique. Ultimately it has been established that the eleven-hidden-nodes three-layered neural network has more efficacy than asymptotic regression in the present forecasting task.
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Figueroa-O’Farrill, José. "Symmetric M-theory backgrounds." Open Physics 11, no. 1 (January 1, 2013): 1–36. http://dx.doi.org/10.2478/s11534-012-0160-6.
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AbstractWe classify symmetric backgrounds of eleven-dimensional supergravity up to local isometry. In other words, we classify triples (M, g, F), where (M,g) is an eleven-dimensional lorentzian locally symmetric space and F is an invariant 4-form, satisfying the equations of motion of eleven-dimensional supergravity. The possible (M,g) are given either by (not necessarily nondegenerate) Cahen-Wallach spaces or by products AdSd × M11−d for 2 ⩽ d ⩽ 7 and M11−d a not necessarily irreducible riemannian symmetric space. In most cases we determine the corresponding F-moduli spaces.
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Baćak, Valerio, and Sigrún Ólafsdóttir. "Gender and validity of self-rated health in nineteen European countries." Scandinavian Journal of Public Health 45, no. 6 (July 4, 2017): 647–53. http://dx.doi.org/10.1177/1403494817717405.
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Aims: The aims of this study were to: (1) examine the concurrent validity of self-rated health for mental and physical health in Europe; and (2) evaluate whether self-rated health predicts health problems differentially by gender. Methods: Data are from 19 European countries surveyed in the 2014 European Social Survey. We applied ordinary least squares regression to examine the association between self-rated health and summary indicators of physical and mental health problems. Results: We observed an association between self-rated health and both physical and mental health problems in all countries. Gender differences in the concurrent validity of self-rated health were documented in eleven out of 19 countries. Conclusions: Self-rated health is a valid and efficient measure of physical and mental health across the European continent, with significantly greater concurrent validity among women.
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Khusniati, Tatik. "PRESERVATION OF MILKS WITH ADDITION OF ANTIBACTERIAL AND AROMATIC SUPPLEMENTS PRODUCED IN JAPAN." ASEAN Journal on Science and Technology for Development 25, no. 1 (November 19, 2017): 1–13. http://dx.doi.org/10.29037/ajstd.225.
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The good antibacterial and aromatic supplements produced in Japan for preservation of milks at storage was investigated. Nineteen sweet and herb materials were made juices as supplements to preserve the milks. Bacterial counts, pH, protease activities and lipase activities of supplemented milks, and antibacterial activities of supplements were detected by total plate counts, glass electrode pH meter, azocasein, modified Dole extraction and turbidity methods. Eleven of nineteen milks added 10% of honey, garlic, ginger, horseradish, “sansho”, “yuzu”, green perilla, “nira”, green tea, bamboo leaf and “yomogi” were selected as good supplemented milks based on pH of these milks closed to pH of milks, the lower bacterial counts, protease activities and lipase activities of these milks than that without supplements, at 5 days before up to 10 days after use by date (P<0.05), consumed materials and antibacterial activities of these supplements in inhibiting Pseudomonas fluorescens P. 33 in the nutrient media.
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Lozano, Y. "Eleven dimensions from the massive D-2-brane." Physics Letters B 414, no. 1-2 (November 1997): 52–57. http://dx.doi.org/10.1016/s0370-2693(97)01143-x.
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Willis, Michael G., and David S. Treves. "Isolation and Characterization of Halotolerant 2,4- Dichlorophenoxyacetic Acid Degrading Bacteria From Sulfidic, Low Salinity Salt Springs." Fine Focus 1, no. 1 (December 1, 2014): 39–50. http://dx.doi.org/10.33043/ff.1.1.39-50.
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The bacterial communities at two sulfidic, low salinity springs with no history of herbicide contamination were screened for their ability to grow on 2,4-dichlorophenoxyacetic acid (2,4-D). Nineteen isolates, closely matching the genera Bacillus, Halobacillus, Halomonas, Georgenia and Kocuria, showed diverse growth strategies on NaCl-supplemented and NaCl-free 2,4-D medium. The majority of isolates were halotolerant, growing best on nutrient rich broth with 0% or 5% NaCl; none of the isolates thrived in medium with 20% NaCl. The tfdA gene, which codes for an a – ketoglutarate dioxygenase and catalyzes the first step in 2,4-D degradation, was detected in nine of the salt spring isolates. The tfdAa gene, which shows ~60% identity to tfdA, was present in all nineteen isolates. Many of the bacteria described here were not previously associated with 2,4-D degradation suggesting these salt springs may contain microbial communities of interest for bioremediation.
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Arumemi, Fortuna, and Christine Milcarek. "Determination of protein-protein interactions of human eleven-nineteen lysine-rich leukemia protein ELL2 (176.8)." Journal of Immunology 188, no. 1_Supplement (May 1, 2012): 176.8. http://dx.doi.org/10.4049/jimmunol.188.supp.176.8.
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Abstract Eleven-nineteen lysine-rich leukemia (ELL) genes produce protein factors that aid in transcription elongation. ELL1 was originally found as a fusion partner with MLL in some multiple lineage leukemias. ELL2 mRNA and protein are induced 6-fold in plasma cells. ELL1 and ELL2 are very similar except for 2 regions between amino acids 352 - 443 and 473 - 516, indicating that they may have different sets of interacting proteins. Yeast two-hybrid (Y2H) assays were performed to determine what proteins might interact with each ELL. ELL2, was subcloned into four main sections (A1, A2, B, and C) to determine specific locations of interaction. The C portion of ELL2, aa 516 to 640, autoactivated transcription in the Y2H and was not further analyzed. Meanwhile, the A1 region interacted with CEP192 (regulator of pericentriolar material recruitment, centrosome maturation, and centriole duplication in mammalian cells); the A2 region interacted with RP3 gene (XLRP gene 3), FIGNLI (new subfamily member of ATPases associated with diverse cellular activities); and the B region interacted with HIFIA (transcription factor found in mammalian cells under reduced oxygen tension that plays an essential role in hypoxia) and SEC63 (a translocation protein). Further mapping of the interactions of the ELLs may help us to clarify their functions in gene regulation and plasma cell development.
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Parikh, S., E. Dawe, C. Lee, T. Whitehead-Clarke, C. Smith, and S. Bendall. "A cadaveric study showing the anatomical variations in the branches of the dorsalis pedis artery at the level of the ankle joint and its clinical implication in ankle arthroscopy." Annals of The Royal College of Surgeons of England 99, no. 4 (April 2017): 286–88. http://dx.doi.org/10.1308/rcsann.2016.0288.
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Introduction Pseudoaneurysm formation following ankle arthroscopy is a rare but potentially catastrophic complication. The placement of anterior ankle portals carries inherent risk to the superficial and deep peroneal nerves, as well as to the dorsalis pedis artery. Anatomical variations in the dorsalis pedis and the presence of branches at the joint line may increase the risk of vascular injury and pseudoaneurysm formation during arthroscopy. There is limited anatomical evidence available regarding the branches of the dorsalis pedis artery, which occur at the point at which they cross the ankle joint. Objectives The objective of the study was to describe the frequency and direction of branches of the dorsalis pedis crossing the ankle joint. Materials and Methods Nineteen cadaveric feet were carefully dissected to explore the course of the dorsalis pedis artery, noting in particular the branching pattern at the joint line. Results Eleven of the nineteen feet had a branch of the dorsalis pedis artery that crossed the level of the ankle joint. Out of these, six were lateral, four medial and one bilateral. Eight of the eleven specimens had one branch at, or just before, the level of the joint. Two specimens had two branches and one had three branches crossing the ankle, which were all in the same direction, crossing laterally to the main trunk of the dorsalis pedis. Conclusions Our study demonstrated high rates of branching of the dorsalis pedis artery at the level of the ankle joint. The role of these branches in pseudoaneurysm formation during anterior hindfoot surgery remains unclear.
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Staub, Jack E., Vladimir Meglic, and James D. McCreight. "Inheritance and Linkage Relationships of Melon (Cucumis melo L.) Isozymes." Journal of the American Society for Horticultural Science 123, no. 2 (March 1998): 264–72. http://dx.doi.org/10.21273/jashs.123.2.264.
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Nineteen polymorphic and eleven monomorphic isozyme loci were identified in thirteen enzyme systems in a survey of four-hundred melon (Cucumis melo L.) accessions. Segregation of allozymes in F2 and backcross (BC) families for isozyme loci agreed with the expected 1:2:1 and 1:1 segregation ratios (P <0.01). Eleven isozyme loci were linked and were integrated to form a map containing two linkage groups spanning 98 cM with a mean linkage distance of ≈9 cM. Linkage groups (A and B) contain the following loci in the order: A Fdp-2, Pgd, Pgm, Mpi-1, Idh, and Ac, and B Pep-gl, Mdh-2, Mdh-4, Mdh-5, Mdh-6. The remaining eight loci (Acp-1, Acp-4, Ak-4, Fdp-1, Gpi, Mpi-2, Pep-la, and Pep-pap) segregated independently. The isozyme map constructed in this study provides genomic information for future linkage studies with economically important traits and concensus map construction through map merging.
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Prado, G. Fernandes do, L. B. C. Carvalho, A. Baptista da Silva, and J. G. C. Lima. "EEG and dementia indicators in AIDS patients' Rorschach test." Arquivos de Neuro-Psiquiatria 52, no. 3 (September 1994): 314–19. http://dx.doi.org/10.1590/s0004-282x1994000300005.
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We studied the EEG and Rorschach test (RT) of nineteen AIDS patients and eight normal people in the same age group. Eight patients presented slow alpha rhythms (8 to 9 Hz); three, not-slow alpha rhythms (>9 to 13Hz); and eight, beta rhythms in background activity. Paroxystic activity, characterized by diffuse theta or delta waves, was present in eleven patients. We observed Oberholzer syndrome (organic dementia diagnosed by RT) in ten patients and Piotrowski syndrome (organic dementia diagnosed by RT) in eleven patients; six presented both. When considering only the group of AIDS patients, we did not observe a significant relation among slow alpha rhythm, not-slow alpha rhythm and the presence of paroxystic activity with the above-mentioned syndromes. AIDS patients with slow alpha rhythms showed a significantly greater number of Piotrowski syndrome dementia indicators when compared to normal individuals or those with slow alpha rhythms. We did not observe the same with Oberholzer syndrome.
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Correa, Juan Andrés González, Sandra Liliana Sánchez Castañeda, Deisy Aydee Velandia Quintero, and Germán Eduardo Giraldo. "Identification and Analysis of Project Management Success Factors in Information Technology SMEs." International Journal of Information Technology Project Management 9, no. 4 (October 2018): 73–90. http://dx.doi.org/10.4018/ijitpm.2018100105.
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This article identifies and analyses the success factors involved in project management through an exploratory study that encompasses nineteen interviews, fifty-seven surveys and one session with a focus group of project managers, department managers who have taken the role of project managers and general managers of small and medium-sized enterprises (SMEs) of the information technology (IT) sector in Bogota, Colombia. After analyzing the information, the authors identified eleven factors for the achievement of project management goals in these organizations. These comprise managerial, organizational and sector aspects that influence the resource management and leadership in projects of SMEs of information technology.
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Müller, Frank. "New bryophyte records for West and Central African countries." Acta Biologica Plantarum Agriensis 11, no. 1 (2023): 90–106. http://dx.doi.org/10.21406/abpa.2023.11.1.90.
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Nineteen new country records for Liberia, eleven for Ivory Coast, two for the Democratic Republic of the Congo, and three from Equatorial Guinea (Bioko) are presented. The following new combination is proposed: Entosthodon cam eruniae (Dixon) N.Wilding ex Frank Müll., comb. nov. (Basionym: Funaria cam eruniae Dixon). Figure plates are presented for Entosthodon cam eruniae and Trachypodopsis normandii. The latter one, an endemic of mountainous areas of West Africa and hitherto only known from Fouta Djallon in Guinea and the Loma Mountains in Sierra Leone could be the first record for the Nimba Mountains of Liberia.
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Hawramy, Omran, Waleed Al-Obidee, and Nisreen Aziz. "Campanian-Maastrichtian Ostracods (Crustacea) From the Shiranish Formation, Dukan Area, Kurdistan Province, Northern Iraq." Iraqi Geological Journal 56, no. 1C (March 31, 2023): 74–93. http://dx.doi.org/10.46717/igj.56.1c.6ms-2023-3-17.
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The present study represents a detailed systematic study of obtained ostracods in sixty three samples from an outcrop section of the Shiranish Formation (Campanian – Maastrichtian), Dukan area, Kurdistan, northern Iraq. Thirty ostracod species belonging to twenty one genera are found, whereas nineteen species are previously recorded. Eleven new described species are detected, which three new species represented in Bairdia dukanensis sp. nov., Bairdoppilata shiranishensis sp. nov. and Hornibrookella nudosa sp. nov. are newly renamed by the authors according to the scientific roles of nomenclature, and nine species are systemacilly described as (sp.) due to the lack of satisfied specimens.
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Al-Hamamy, Hayder R., Husam Ali Salman, and Nawar A. Abdulsattar. "Treatment of Plane Warts with a Low-Dose Oral Isotretinoin." ISRN Dermatology 2012 (December 12, 2012): 1–3. http://dx.doi.org/10.5402/2012/163929.
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Objective. To assess the efficacy of a low-dose oral isotretinoin in the treatment of plane warts. Patients and Methods. Thirty-one patients with recalcitrant facial plane warts were enrolled. A cumulative dose of 30 mg/kg for two months of treatment was calculated; this was equal to a mean of 0.5 mg/kg/day. Each patient was seen every two weeks during the treatment period. Response to treatment was either complete or no response. Patients with complete response were followed up monthly for four months to record the relapse rate. Results. Twenty-six patients completed the study; their ages range from 5 to 35 with a mean ± SD years. Fifteen (57.69%) patients were females and eleven (42.30%) were males. Nineteen (73.07%) patients showed complete response and seven (26.92%) patients showed no response at the end of two months of therapy. The difference was statistically significant; P value . Fifteen (78.94%) out of nineteen patients, who had complete response, were still free from warts at the end of four-month followup. Conclusion. Oral isotretinoin is effective in the treatment of recalcitrant facial plane warts.
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Prata, Pedro H., Matthieu Resche-Rigon, Didier Blaise, Gérard Socié, Pierre Simon Rohrlich, Noel-Jean Milpied, Pascal Turlure, et al. "Outcomes of Salvage Haploidentical Transplant with Post-Transplant Cyclophosphamide for Rescuing Primary Graft Failure Patients : A Report By the SFGM-TC." Blood 132, Supplement 1 (November 29, 2018): 4663. http://dx.doi.org/10.1182/blood-2018-99-111610.
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Abstract Prognosis of graft failure patients is dismal, and another transplant is the sole option for long-term survival. Currently, there is no consensus concerning the best option for treating patients undergoing primary graft failure and finding a new donor within an acceptable delay is challenging. In the last years, haploidentical transplants with post-transplant cyclophosphamide (PT-Cy) have shown acceptable results in the treatment of many hematological diseases, including some cases of graft failure. To address the interest of haploidentical transplants as a salvage option in this context, we retrospectively collected and analyzed data from 26 primary graft failure (PGF) patients transplanted between 2011 and 2017 in 15 centers belonging to the Francophone Society for Bone Marrow Transplantation and Cellular Therapy (SFGM-TC). Inclusion criteria were the occurrence of PGF defined as non-achievement of a minimum absolute neutrophil count of 500/μL without evidence of disease relapse at D+28 after transplantation and the use of a haploidentical transplantation with PT-Cy as graft-versus-host-disease (GvHD) prophylaxis. Continuous variables are presented as medians and inter-quartile range. They were compared between groups using the Wilcoxon rank sum. Categorical variables are presented with counts and percentages and were compared using the Fisher exact test. All tests were 2-sided, and a p-value below 0.05 was considered to be significant. Analyses were performed using the R statistical platform (version 3.4.1). This study was performed according to the Declaration of Helsinki and was approved by the SFGM-TC scientific council. Nineteen patients had a diagnosis of myeloid malignancy (8 acute myeloid leukemias, 4 myelodysplastic syndromes, 4 myeloproliferative neoplasms, 1 unclassified myeloid disorder), 3 had a lymphoid neoplasm, and 4 had a bone marrow failure syndrome (2 acquired and 2 congenital). Twenty-four patients had previously received an allogeneic transplantation, and 2 had already failed two previous allogeneic transplants. Male/female ratio was 2.25. Median age at haploidentical transplant was 42 years (2-58). Fifteen patients received peripheral blood as stem cell source, and 11 received bone marrow. Eleven transplants were female to male. Twelve patients received an ABO-matched graft, 6 had a major ABO-incompatibility, 7 a minor incompatibility and one missing data. The median number of infused CD34+ cells was 5.2 x106/kg (1.2 - 12.5). There was no ex-vivomanipulation of cells. CMV matching was available for 22 transplantations, of which 6 were high-risk (seropositive recipient with a seronegative donor). Fludarabine-based reduced intensity conditioning was used in all but one patient who received clofarabine + 4Gy TBI. Twenty patients received TBI 2Gy. Three patients received ATG. Fourteen patients received the Baltimore regimen (53%). The median delay between the previous and the salvage transplantation was 77 days (39-1161). All patients received PT-Cy associated with cyclosporine, and 24 patients also received MMF for GvHD prophylaxis. Median follow up was 487 (16-2010) days. The cumulative incidence (CI) of neutrophil recovery at day 30 was 81%, and the median time to neutrophil engraftment was 19 (13-34) days. Four patients (15%) presented primary graft failure and died within a median time of 5 (3-8) weeks after transplantation of infectious complications. Cumulative incidence of grade II-IV aGvHD at day-100 was 13%, and 1-year CI of cGvHD was 32%. One-year CI of relapse was 16%. Overall survival was 58% at 1 year (Figure 1; confidence interval: 39-85). Among the 22 patients who engrafted, 6 patients died. HSCT complications accounted for 80% of the causes of deaths (4 multiorgan failure, 1 GvHD, 1 interstitial pneumonitis, 1 bacterial infection, 1 post-transplant lymphoproliferative disorder). To the best of our knowledge, this is the first cohort describing the outcomes of haploidentical transplants with PT-Cy rescuing patients with primary graft failure. Our cohort presents promising outcomes in a particularly challenging situation, suggesting that haploidentical transplants with PT-Cy might appear as a valid salvage strategy for patients with PGF. Prospective well-designed trials are urgently needed before the inclusion of Haplo-PT-Cy in the treatment strategy of patients with PGF. Figure 1. Figure 1. Disclosures Mohty: MaaT Pharma: Consultancy, Honoraria. Peffault De Latour:Pfizer Inc.: Consultancy, Honoraria, Research Funding; Alexion Pharmaceuticals, Inc.: Consultancy, Honoraria, Research Funding; Amgen Inc.: Research Funding; Novartis: Consultancy, Honoraria, Research Funding.
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Vanniasegaram, Sithparran. "Le Her with s Suits and d Denominations." Journal of Applied Probability 43, no. 1 (March 2006): 1–15. http://dx.doi.org/10.1239/jap/1143936239.
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In 2002, Benjamin and Goldman gave a complete solution to a variant of the two-player card game Le Her. We extend their result by giving optimal strategies for the authentic version played with a deck consisting of arbitrary numbers of suits and denominations. Additionally, we show that the player who has the advantage in the game when one standard deck is used does not have the advantage if nineteen or more standard decks are used.
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Vanniasegaram, Sithparran. "Le Her with s Suits and d Denominations." Journal of Applied Probability 43, no. 01 (March 2006): 1–15. http://dx.doi.org/10.1017/s0021900200001327.
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In 2002, Benjamin and Goldman gave a complete solution to a variant of the two-player card game Le Her. We extend their result by giving optimal strategies for the authentic version played with a deck consisting of arbitrary numbers of suits and denominations. Additionally, we show that the player who has the advantage in the game when one standard deck is used does not have the advantage if nineteen or more standard decks are used.
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Tosic, Snezana, Aleksandra Pavlovic, Ivana Dimitrijevic, Ivana Zlatanovic, Violeta Mitic, and Gordana Stojanovic. "Elemental composition of selected lichen species growing on the Balkan Peninsula." Journal of the Serbian Chemical Society, no. 00 (2022): 49. http://dx.doi.org/10.2298/jsc220223049t.
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The amount of nineteen elements in eleven different lichen species, six fruticose (Bryoria capillaris, Bryoria fuscescens, Cladonia rangiformis, Rama-lina capitata, Usnea chaetophora and Evernia prunastri) and five foliose (Hypogymnia tubulosa, Lobaria pulmonaria, Peltigera horizontalis, Umbilicaria cylindrica and Umbilicaria crustulosa) from five natural areas of the Balkan Peninsula (Serbia and Bulgaria) were determined by using inductively coupled plasma optical emission spectrometry (ICP-OES). The most common major elements were Ca and K and the least common ones were Mg and Na. Fe, Mn, Zn and Ba were the most common trace elements while Cd and Co were the least common. The obtained results were statistically processed.
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Bazaoui, Ahmed El, My Ahmed Bellimam, Ibn Toumert Lançar, and Abdelmajid Soulaymani. "Gas-Liquid Chromatography-Mass Spectrometry Investigation of Tropane Alkaloids in Hyoscyamus albus L. from Morocco." Zeitschrift für Naturforschung C 67, no. 9-10 (October 1, 2012): 461–65. http://dx.doi.org/10.1515/znc-2012-9-1003.
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Thirty-four alkaloids were identified in the organs of Hyoscyamus albus L. by gas-liquid chromatography-mass spectrometry (GLC-MS). Eight new compounds for the roots, eleven for the stems, twelve for the leaves, nineteen for the flowers, and seven for the seeds were detected. The alkaloids 5-(2-oxopropyl)-hygrine (8) and phygrine (20) are new for this species and 3-(hydroxyacetoxy)tropane (9), 6,7-dehydro-3-phenylacetoxytropane (15), 3-(2’-phenylpropionyloxy) tropane (17), 6,7-dehydro-3-apotropoyloxytropane (18), 3-(3’-methoxytropoyloxy)tropane (23), and aponorscopolamine (25) are described for the first time for the genus Hyoscyamus. Hyoscyamine was the main alkaloid in the plant organs
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Saab, Maysa, and Eman Shaaban. "The Impact of Modeling and Role Play on Grade Eleven Students’ Achievement and Motivation While Teaching Krebs Cycle in Biology." International Journal of Research in Education and Science 8, no. 2 (May 22, 2022): 219–42. http://dx.doi.org/10.46328/ijres.2692.
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This study investigated the effect of applying “participant modeling” followed by a role play on grade eleven scientific students’ achievement and motivation in biology. Students usually face problems in understanding difficult biology concepts like Krebs cycle which is composed of a series of biochemical reactions with many molecules and compounds involved. The researcher designed t-shirts with information about the molecules and the reactions of Krebs cycle and students were asked to wear them throughout the teaching/learning process. Implementing participant modeling helped students to memorize the names of the molecules, their role. Then a role play was applied after modeling to relate the chemical reactions together. Nineteen students with ages ranging between 16 and 17 (N=19) enrolled in grade eleven scientific participated in this study. Data was collected using pre and post-achievement tests, and a motivation test that was implemented before and after the intervention. Results showed a significant enhancement in achievement, but no significant change occurred at the level of motivation. Ultimately, recommendations related to both methodology and future researches are offered.
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Ahmed, Parveen, Abu Ishaque, Tanveen Isaque, Murshida Yeasmin, and AKM Mazharul Islam. "Fetal Renal Obstruction is Early Detected during Pregnancy by Ultrasonography at Urban Hospital (Naraynganj)." Medicine Today 28, no. 2 (June 13, 2017): 72–74. http://dx.doi.org/10.3329/medtoday.v28i2.32930.
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Over the last 3years (September 2012 to September 2015) for the period of 36 months after searching of all gravid uterus ultrasonography report only 40 patients having hydronephrosis detected during antenatal checkup both Naraynganj General Hospital Radiology and Imaging department and Private Clinic, primary finding is oligo hydraminos between 10 weeks to 16 weeks of gestation. All the patients of our study population were subjected to imaging by ultrasonography. This was a prospective study. Out of 40 fetus hydronephrosis were graded according to sonographic grading system. There were two fetus of grade 0, eight fetus of grade-1, eleven fetus grade-2, are nineteen fetus of grade 3 hydronephrosis on advance pregnancyMedicine Today 2016 Vol.28(2): 72-74
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Ferreira Freitas, Sara. "KAYAPÓ KUKRÃDJÀ." Revista Gênero e Interdisciplinaridade 4, no. 04 (September 5, 2023): 544–56. http://dx.doi.org/10.51249/gei.v4i04.1545.
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The present work aims to gather data and characteristics regarding the Kayapó indigenous peoples, proposing to observe the mythical, the symbolic, the meaning present in the culture, customs and politics of the Mebengokrê. Based on this assumption, we sought to understand the relationship with the conservation of indigenous territories, their cultural manifestations, rituals, cuisine and the artistic image as a means of expression, as well as body painting and indigenous artifacts that permeate their social life. Belonging to the Jê linguistic family, they are consolidated into 19 (nineteen) communities, occupying a territory of 11 (eleven) million hectares between the states of Mato Grosso and Pará, in the heart of the Brazilian Amazon forest
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Pascual-Le Tallec, Laurent, Federico Simone, Say Viengchareun, Geri Meduri, Michael J. Thirman, and Marc Lombès. "The Elongation Factor ELL (Eleven-Nineteen Lysine-Rich Leukemia) Is a Selective Coregulator for Steroid Receptor Functions." Molecular Endocrinology 19, no. 5 (May 1, 2005): 1158–69. http://dx.doi.org/10.1210/me.2004-0331.
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DISNEY, R. H. L. "Three new species and a new key to the Diplonevra Lioy (Diptera: Phoridae) from Australia." Zootaxa 2792, no. 1 (March 16, 2011): 41. http://dx.doi.org/10.11646/zootaxa.2792.1.4.
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Rogerio, Kamilla Rodrigues, Cedric Stephan Graebin, Luiza Helena Pinto Domingues, Luana Santos Oliveira, Vitoria de Souza Fernandes da Silva, Claudio Tadeu Daniel-Ribeiro, Leonardo J. M. Carvalho, and Nubia Boechat. "Novel Quinolinyl-pyrrolo[3,4-d]pyrimidine-2,5-dione Derivatives Against Chloroquine-resistant Plasmodium falciparum." Current Topics in Medicinal Chemistry 20, no. 2 (February 19, 2020): 99–110. http://dx.doi.org/10.2174/1568026619666191019100711.
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Introduction: In this work DHPMs were combined with the quinoline nucleus to obtain new quinolinyl-pyrrolo[3,4-d]pyrimidine-2,5-dione compounds with improved antiplasmodial activity as well as decreased cytotoxicity. Nineteen quinolinyl-pyrrolo[3,4-d]pyrimidine-2,5-dione derivatives connected by a linker group to quinolone ring moieties with different substituents were synthesized and assayed against P. falciparum. Materials and Methods: Nineteen quinolinyl-pyrrolo[3,4-d]pyrimidine-2,5-dione derivatives connected by a linker group to quinoline ring moieties with different substituents were synthesized and assayed against chloroquine-resistant Plasmodium falciparum, along with the reference drug chloroquine. Among these compounds, the derivatives with two methylene carbon spacers showed the best activity accompanied by low cytotoxicity. Results: The derivative without substituents on the aromatic ring (2a) and the derivative with a chlorine group at position 4 (2d) provided the best results, with IC50 = 1.15 µM and 1.5 µM, respectively. Conclusion: Compared to the parent drugs, these compounds presented marked decreases in cytotoxicity, with MDL50 values over 1,000 µM and selectivity indexes of >869.5 and >666.6, respectively. The quinolinyl-pyrrolo[3,4-d]pyrimidine-2,5-dione framework appears to be promising for further studies as an antimalarial for overcoming the burden of resistance in P. falciparum.
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Hawkins, Sarah, and Jonathan Midgley. "Formant frequencies of RP monophthongs in four age groups of speakers." Journal of the International Phonetic Association 35, no. 2 (December 2005): 183–99. http://dx.doi.org/10.1017/s0025100305002124.
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This study describes the frequencies of the first two formants of monophthongs produced by male RP speakers in four age groups: aged 20–25, 35–40, 50–55, and 65–73 years in 2001. The eleven monophthongs were spoken in /hVd/ contexts by five men in each age group. The eleven words, together with nineteen filler words chosen to distract attention from the purpose of the experiment, were randomized four times and read by each speaker in citation form, for a total of 880 items. F1 and F2 frequencies were measured in Hz and ERB-rate. As expected, in younger compared with older speakers, F1 is higher in /ε/ and especially /æ/, and F2 is higher in /u:/ and /υ/. Other vowels varied in overall dispersion of F1 or F2, but no other differences between age groups were observed. There is evidence that the oldest age group to show change in a vowel's quality has particularly large differences between individuals, so that, collectively, members of that group span much of the quality range from ‘conservative’ (older groups) to ‘progressive’ (younger groups). Such so-called ‘break groups’ have implications for theoretical explanations of sound change.