Academic literature on the topic 'Nineteen eleven, A.D'
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Journal articles on the topic "Nineteen eleven, A.D"
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Di Bari, Virginia, Gina Gualano, Maria Musso, Raffaella Libertone, Carla Nisii, Stefania Ianniello, Silvia Mosti, et al. "Increased Association of Pulmonary Thromboembolism and Tuberculosis during COVID-19 Pandemic: Data from an Italian Infectious Disease Referral Hospital." Antibiotics 11, no. 3 (March 16, 2022): 398. http://dx.doi.org/10.3390/antibiotics11030398.
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Pulmonary thromboembolism (PTE) has been associated with tuberculosis (TB), but the true incidence is unknown. The aim of our study was to retrospectively evaluate the PTE prevalence in TB patients hospitalized at the National Institute for Infectious Diseases L. Spallanzani during the January 2016–December 2021 period. Retrospective data collection and evaluation were conducted. Among 1801 TB patients, 29 (1.61%) exhibited PTE. Twenty (69%) had comorbidities; eleven (37.9%) had predisposing factors for PTE. Nineteen (65.5%) had extensive TB disease. The commonest respiratory symptoms were cough (37.9%), dyspnea (31%), chest pain (10.3%), and hemoptysis (6.9%). Twenty-five (86.2%) had elevated serum D-dimer levels. An increased prevalence of PTE from 0.6% in the pre-COVID-19 pandemic period to 4.6% in the pandemic period was found. Acute respiratory failure and extensive TB disease increased significantly in the pandemic period. The increase in PTE could be explained by the increased severity of TB in patients in the pandemic period and by increased clinical suspicion and, consequently, increased requests for D-dimer testing, including in patients with non-COVID-19 pneumonia. Patients with extensive pulmonary disease are at high risk of developing PTE. Clinicians should be aware of this potentially life-threatening complication of TB, and patients should receive a thromboembolism risk assessment.
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Lightowler, Helen J., and G. Jill Davies. "Iodine intake and iodine deficiency in vegans as assessed by the duplicate-portion technique and urinary iodine excretion." British Journal of Nutrition 80, no. 6 (December 1998): 529–35. http://dx.doi.org/10.1017/s0007114598001627.
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I intake and I deficiency were investigated in thirty vegans (eleven males and nineteen females) consuming their habitual diet. I intake was estimated using the chemical analysis of 4 d weighed duplicate diet collections. The probability of I-deficiency disorders (IDD) was judged from the measurement of urinary I excretion in 24 h urine specimens during the 4 d. There was wide variation in I intake. Mean I intake in males was lower than the reference nutrient intake (RNI; Department of Health, 1991) and mean intake in females was above the RNI, although 36% males and 63% females had I intakes below the lower RNI. Mean I intake in subjects who consumed seaweed (n 3) was in excess of the RNI, and approached the provisional maximum tolerable daily intake (World Health Organization/Food and Agriculture Organization Joint Expert Committee on Food Additives, 1989). The probability of IDD in the group investigated was moderate to severe: three of five subgroups were classified as moderate and two subgroups were classified as severe IDD possibility. The findings highlight that vegans are an ‘at risk’ group for I deficiency. The I status of vegans and the subclinical effects of low I intakes and infrequent high I intakes on thyroid function in this group should be further studied. Our work has also raised the question of adequate I intakes in groups where cow's milk is not consumed, and has exposed a need for more research in this area.
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Bauer, Brigitte L. M. "Multiplication, addition, and subtraction in numerals: formal variation in Latin’s decads+ from an Indo-European perspective." Journal of Latin Linguistics 22, no. 1 (May 1, 2023): 1–56. http://dx.doi.org/10.1515/joll-2023-2001.
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Abstract While formal variation in Latin’s numerals is generally acknowledged, little is known about (relative) incidence, distribution, context, or linguistic productivity. Addressing this lacuna, this article examines “decads+” in Latin, which convey the numbers between the full decads: the teens (‘eleven’ through ‘nineteen’) as well as the numerals between the higher decads starting at ‘twenty-one’ through ‘ninety-nine’. Latin’s decads+ are compounds and prone to variation. The data, which are drawn from a variety of sources, reveal (a) substantial formal variation in Latin, both internally and typologically; (b) co-existence of several types of formation; (c) productivity of potential borrowings; (d) resilience of early formations; (e) patterns in structure and incidence that anticipate the Romance numerals; and (f) historical trends. From a typological and general linguistic perspective as well, Latin’s decads+ are most relevant because their formal variation involves sequence, connector, and arithmetical operations and because their historical depth shows a gradual shift away from widespread formal variation, eventually resulting in the relatively rigid system found in Romance. Moreover, the combined system attested in decads+ in Latin – based on a combination of inherited, innovative and borrowed patterns and reflecting different stages of development – presents a number of typological inconsistencies that require further assessment.
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Bell, Lucinda K., Gilly A. Hendrie, Jo Hartley, and Rebecca K. Golley. "Impact of a nutrition award scheme on the food and nutrient intakes of 2- to 4-year-olds attending long day care." Public Health Nutrition 18, no. 14 (January 28, 2015): 2634–42. http://dx.doi.org/10.1017/s1368980014003127.
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AbstractObjectiveEarly childhood settings are promising avenues to intervene to improve children’s nutrition. Previous research has shown that a nutrition award scheme, Start Right – Eat Right (SRER), improves long day care centre policies, menus and eating environments. Whether this translates into improvements in children’s dietary intake is unknown. The present study aimed to determine whether SRER improves children’s food and nutrient intakes.DesignPre–post cohort study.SettingTwenty long day care centres in metropolitan Adelaide, South Australia, Australia.SubjectsChildren aged 2–4 years (n 236 at baseline, n 232 at follow-up).MethodsDietary intake (morning tea, lunch, afternoon tea) was assessed pre- and post-SRER implementation using the plate wastage method. Centre nutrition policies, menus and environments were evaluated as measures of intervention fidelity. Comparisons between baseline and follow-up were made using t tests.ResultsAt follow-up, 80 % of centres were fully compliant with the SRER award criteria, indicating high scheme implementation and adoption. Intake increased for all core food groups (range: 0·2–0·4 servings/d, P<0·001) except for vegetable intake. Energy intake increased and improvements in intakes of eleven out of the nineteen nutrients evaluated were observed.ConclusionsSRER is effective in improving children’s food and nutrient intakes at a critical time point when dietary habits and preferences are established and can inform future public health nutrition interventions in this setting.
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Bailey, H., J. Kolesar, T. Fass, J. Weiss, J. Heideman, D. Alberti, and S. Morgan-Meadow. "A phase I study of LR-103 (1,24α(OH)2D2) in patients with refractory malignancies." Journal of Clinical Oncology 24, no. 18_suppl (June 20, 2006): 14608. http://dx.doi.org/10.1200/jco.2006.24.18_suppl.14608.
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14608 Background: Preclinical studies of calcitriol and vitamin D analogs demonstrate potent growth inhibition of tumor cell lines. The clinical development of calcitriol and other analogs have been hindered by hypercalcemia. 1α (OH)D2 is a Vitamin D analog which has produced objective responses in advanced androgen-independent prostate cancer patients and can be administered daily at 10mcg. LR103 is an active metabolite of 1α (OH)D2 with equivalent anti-tumor activity and significantly less calcemic effects in preclinical studies. This phase I study explores the maximal tolerated dose and toxicity of LR-103. Methods: LR-103 was administered daily beginning at a dose of 5 μg/day with a cycle length of 14 to 28 days. Dose escalation proceeded in two stages. In step A, intra-patient dose escalation (starting dose of 5mcg daily) was allowed based on degree of toxicity regardless of attribution. Step A escalation continued until 2 patients had ≥ grade 2 toxicity at a dose level. Step B is a standard, inter-patient only, dose-escalation trial (starting dose based on Step A) with cohorts of three. Dose limiting toxicity is defined as ≥ grade 3 toxicity. Results: Nineteen patients have enrolled between May and December 2005, eight to step A and eleven to step B. During step A escalation, two patients at 15 μg/day experienced severe toxicity (grade 4 hyperuricemia and grade 3 alkaline phosphatase) and two patients at 15 μg/day experienced grade 1 hypercalcemia. Hypercalciuria has been common. No hypercalcemia ≥ grade 2 has been observed. Step B enrollment continues at 30 μg/day without hypercalcemia. Conclusions: Daily administration of LR-103 has not resulted in significant hypercalcemia to date. Dose escalation continues. No significant financial relationships to disclose.
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Stephen, Alison M., H. S. Wiggins, H. N. Englyst, T. J. Cole, B. J. Wayman, and J. H. Cummings. "The effect of age, sex and level of intake of dietary fibre from wheat on large-bowel function in thirty healthy subjects." British Journal of Nutrition 56, no. 2 (September 1986): 349–61. http://dx.doi.org/10.1079/bjn19860116.
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1. To evaluate the effect of age, sex and level of intake on the colonic response to wheat fibre, thirty healthy volunteers aged 17–62 years (nineteen men, eleven women) recruited from a local industry, were divided into four groups and given a controlled diet for two 3-week periods. The diet contained white bread during one period or one of four different amounts of bran-enriched wholemeal bread during the other (30, 60, 110, 170 g/d).2. Wide variation was observed between subjects in stool weight on the basal diet and in response to wheat fibre. Stepwise regression analysis showed that the variation in stool weight was significantly related to sex (t4.0, P <0.001) but not to age, height, weight or energy:fibre intakes on the basal diet. Stool weight in men (162(SE 11) g/d) was approximately double that in women (83(SE 11) g/d). Transit time and stool weight were closely related and the effect of sex on stool weight could be explained entirely by differences in transit.4. Faecal carbohydrate excretion increased with the addition of bran mainly due to increased amounts of cellulose and pentose (arabinose+xylose), whilst digestibility of dietary non-starch polysaccharide fell from 77.6 (SE 2.3)% on the white bread diet to 65.6 (SE 2.4)% with the added bran (t 7.4, P < 0.01, n26).5. Faecal pH was more acid in men than in women and was related to methane production. Methane producers had higher faecal pH than non-producers (7.06 (SE 0.1 1) v. 6.65 (SE O.1)), lower stool weight (g/d; 93 (SE 12) v. 156 (SE 13)) and slower transit times (h; 84.6 (SE 11.7) v. 48.6 (SE 6.6)).6. These studies show that, when on similar diets, women have much lower stool weights and slower transit times than men. Furthermore, within the range of amounts of wheat fibre used in this and other published work, stool weight increases in linear proportion to the dose of fibre added to the diet. Methane excretion in breath is associated in this group of subjects with slow transit time and high faecal pH.
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Jo, Ki Hun, So Yeon Lee, Jae Hwan Kwon, and Jooyeon Kim. "Sequential Assessment of External Nasal Deviation Angle Changes in Patients With a Deviated Nose Who Underwent Bilateral Osteotomy." Journal of Craniofacial Surgery 35, no. 4 (June 2024): 1231–35. http://dx.doi.org/10.1097/scs.0000000000010262.
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Objective: A deviated nose is traditionally classified as bony, cartilaginous, or combined deviation. Osteotomy is commonly used to correct bony deviation, and accurate surgical techniques and postoperative patient management are important for favorable outcomes. The authors investigated the change in the external nasal deviation angle over time using sequential clinical photographs to identify the optimal postoperative follow-up duration. Methods: Medical records and sequential standardized clinical photographs of 22 patients who underwent bilateral medial and lateral osteotomies without dorsal augmentation from January 1, 2014 to May 31, 2021, were retrospectively reviewed. Clinical photographs were classified into 4 periods: “a” preoperative, “b” postoperative day (POD) ≤3 weeks, “c” POD ≤9 weeks, and “d” POD >9 weeks. The angle of deviation (AoD) was measured in both frontal and chin-on-chest views for each period. Differences in AoD between temporally adjacent periods were analyzed. Results: Nineteen men and 3 women (mean age: 28.8 y) were included. Thirteen patients showed rightward deviation, whereas 9 showed leftward deviation. Eleven patients underwent surgery through an endonasal approach, whereas the other 11 underwent surgery through an external approach. In the frontal view, AoD differences (mean ± SD) between periods “a” and “b,” “b” and “c,” and “c” and “d” were 5.79 ± 3.36 degrees (P < 0.001), 1.44 ± 1.14 degrees (P < 0.001), and 1.07 ± 1.24 degrees (P < 0.05), respectively. In the chin-on-chest view, the values were 5.17 ± 2.69 degrees (P < 0.001), 2.06 ± 2.63 degrees (P < 0.001), and 1.46 ± 1.31 degrees (P < 0.001), respectively. No statistically significant difference in AoD differences was observed between the two approaches. Conclusions: Angle of deviation can change even 9 weeks after bilateral osteotomy. Thus, long-term follow-up using sequential clinical photographs is mandatory. If needed, close follow-up with early postoperative interventions may be required. The chin-on-chest view showed better sensitivity for assessing AoD than the frontal view.
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Creemers, G. J., G. Bolis, M. Gore, G. Scarfone, A. J. Lacave, J. P. Guastalla, R. Despax, et al. "Topotecan, an active drug in the second-line treatment of epithelial ovarian cancer: results of a large European phase II study." Journal of Clinical Oncology 14, no. 12 (December 1996): 3056–61. http://dx.doi.org/10.1200/jco.1996.14.12.3056.
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PURPOSE Topotecan is a topoisomerase I inhibitor with preclinical activity against various tumor types. We conducted a large multicenter phase II study with topotecan in ovarian cancer in patients who had failed to respond to one prior cisplatin-based chemotherapeutic regimen. PATIENTS AND METHODS Topotecan 1.5 mg/m2/d was administered intravenously by 30-minute infusion for 5 days repeated every 3 weeks. As the cisplatin-free interval relates to response in subsequent treatment, patients were stratified in subgroups, ie, cisplatin-refractory, cisplatin-resistant, and cisplatin-sensitive. RESULTS One-hundred eleven patients entered the study. Nineteen patients were considered to be ineligible; 92 patients were assessable for response. A total of 552 courses were given (median, four per patient; range, one to 17). The major toxicities were leukocytopenia and neutropenia, which were grade 3 to 4 in 54.2% and 69.1% of courses, respectively, but with only 4.3% of these being grade 4 neutropenia plus fever or infectious complications. Prophylactic granulocyte colony-stimulating factor (G-CSF) was given in 20.5% of courses to maintain dose-intensity. Other relatively frequent side effects were alopecia (82%), nausea (36.4%), and vomiting (17.5%). The overall response rate was 16.3%, with one complete response (CR) and 14 partial responses (PRs). In the cisplatin-refractory, cisplatin-resistant, and cisplatin-sensitive strata, the response rates were 5.9%, 17.8%, and 26.7%, respectively. The median duration of time of documented response was 21.7 weeks (range, 4.6 to 41.9). CONCLUSION Topotecan in a daily-times-five schedule is an effective regimen as second-line treatment in ovarian cancer. Further investigations of topotecan in ovarian cancer, including first-line use and combination with other active agents, are indicated.
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GIBBS, JASON. "Revision of the metallic species of Lasioglossum (Dialictus) in Canada (Hymenoptera, Halictidae, Halictini)." Zootaxa 2591, no. 1 (August 31, 2010): 1. http://dx.doi.org/10.11646/zootaxa.2591.1.1.
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The bee subgenus Dialictus (Hymenoptera: Halictidae: Lasioglossum) comprises the most commonly collected bees in North America and have the most diverse social systems of any equivalent group of insects. Despite their importance, as pollinators and as model organisms for studying the evolution of social behaviour, Dialictus remain one of the greatest challenges in bee taxonomy. A taxonomic revision of the metallic species of Canadian Dialictus has been completed which resolves many of the difficulties of these bees. Complete species descriptions with illustrations are provided for 84 metallic Dialictus in Canada along with keys to identify males and females. The following nineteen new species are described: Lasioglossum (Dialictus) abundipunctum new species, L. (D.) atwoodi new species, L. (D.) dashwoodi new species, L. (D.) ebmerellum new species, L. (D.) ephialtum new species, L. (D.) imbrex new species, L. (D.) knereri new species, L. (D.) lilliputense new species, L. (D.) macroprosopum new species, L. (D.) packeri new species, L. (D.) prasinogaster new species, L. (D.) reasbeckae new species, L. (D.) sablense new species, L. (D.) sandhousiellum new species, L. (D.) sheffieldi new species, L. (D.) sitocleptum new species, L. (D.) taylorae new species, L. (D.) timothyi new species, and L. (D.) yukonae Gibbs, new species. Lasioglossum (D.) mitchelli is proposed as a replacement name for L. atlanticum (Mitchell) due to secondary homonymy with Halictus interruptus atlanticus Cockerell, a junior subjective synonym of L. interruptum (Panzer).The following forty-three new synonymies are proposed: L. (D.) admirandum (Sandhouse) (= D. perspicuus Knerer and Atwood); L. (D.) albipenne (Robertson) (= Halictus palustris Robertson, = H. (Chloralictus) lactineus Sandhouse, = H. (C.) basilicus Sandhouse); L. (D.) albohirtum (Crawford) (= H. pilosellus Cockerell); L. (D.) brunneiventre (Crawford) (= H. pilosicaudus Cockerell); L. cattellae (Ellis) (=D. alternatus Mitchell); L. connexum (Cresson) (= H. (C.) politissi-mus Cockerell); L. (D.) cressonii (Robertson) (= D. delectatus Mitchell); L. floridanum (Robertson) (= D. intrepidus Mitchell); L. (D.) foveolatum (Robertson) (= D. supraclypeatus Mitchell); L. (D.) imitatum (Smith) (= H. (C.) insolitus Sandhouse, = D. lectus Mitchell); L. (D.) incompletum (Crawford) (= D. ornduffi Hurd); L. (D.) laevissimum (Smith) (= H. (C.) astutus Sandhouse, = H. (C.) abundus Sandhouse, = H. (C.) jamesae Cockerell, = H. (C.) phaceliarum Cockerell, = H. (C.) praepes Sandhouse, = D. solidaginis Mitchell, = H. (C.) tranquillus Sandhouse); L. (D.) lineatulum (Crawford) (= H. (C.) latus Sandhouse); L. (D.) nigroviride (Graenicher) (= H. (C.) richardsoni Cockerell); L. (D.) obscurum (Robertson) (= D. orbitatus Mitchell); L. (D.) occidentale (Crawford) (= D. theodori Crawford); L. (D). oceanicum (Cockerell) (= D. advertus Mitchell); L. (D.) pavoninum (Ellis) (= H. (C.) evestigatus Sandhouse, = H. (C.) pikei Sandhouse, = H. (C.) abietum Michener); L. (D.) perpunctatum (Ellis) (= D. highlandicus Mitchell, = D. junaluskensis Mitchell); L. (D.) sagax (Sandhouse) (= Halictus (C.) accentus Sandhouse); L. (D.) semibrunneum (Cockerell) (= Halictus oleosus Cockerell); L. (D.) semicaeruleum (Cockerell) (= H. pruinosiformis Crawford, = H. (C.) actuarius Sandhouse); L. (D.) subversans (Mitchell) (= D. perpunctatulus Knerer and Atwood); L. (D.) tenax (Sandhouse) (= H. (C.) meritus Sandhouse, = D. disabanci Knerer and Atwood); L. (D.) versans (Lovell) (= H. (C.) brevibasis Cockerell); L. (D.) versatum (Robertson) (= H. (C.) apertus Sandhouse, = H. (C.) genuinus Sandhouse, = H. subconnexus rohweri Ellis); L. (D.) zephyrum (Smith) (= H. (C.) academicus Sandhouse). Halictus (C.) unicus Sandhouse is again treated as a junior synonym of L. lineatulum. Eleven subgeneric names recently proposed by Pesenko are treated as synonymies of Dialictus. Some species names are used here in a sense different from those of most previous authors (e.g. H. nymphaearus, H. versatus). Names have often been misapplied in past usage sometimes subsuming multiple species. In some cases, even paratypes do not correspond to the same species as the name bearing type. The following three species are resurrected from synonymy: L. (D.) leucocomum (Lovell) new combinaton, L. (D.) oceanicum (Cockerell) new combination, and L. (D.) planatum. The species L. (D.) atriventre (Crawford) is considered a nomen dubium. The following twelve new records for Canada are reported: L. (D.) achilleae (Mitchell), L. (D.) brunneiventre (Crawford), L. (D.) callidum (Sandhouse), L. (D.) incompletum (Crawford), L. (D.) hudsoniellum (Cockerell), L. (D.) marinense (Michener), L. (D.) pacatum (Sandhouse), L. (D.) pallidellum (Ellis), L. (D.) punctatoventre (Crawford), L. (D). sagax (Sandhouse), L. (D.) weemsi (Mitchell) and L. (D.) zophops (Ellis). The Canadian records of two species, L. (D.) disparile (Cresson) and L. (D.) ceanothi (Mitchell), do not seem reliable and these species are not included in the revision. Two species, L. testaceum (Robertson) and L. rufulipes (Cockerell), are transferred from the L. (Dialictus) to L. (Evylaeus) sensu stricto.
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Soverini, Simona, Giovanni Martinelli, Gianantonio Rosti, Simona Bassi, Marilina Amabile, Angela Poerio, Barbara Giannini5, et al. "ABL Mutations in Late-Chronic Phase Chronic Myeloid Leukemia Patients with Cytogenetic Refractoriness to Imatinib Are Associated with a Greater Likelihood of Progression to Blast Crisis and Shorter Survival. on behalf of the GIMEMA Working Party on Chronic Myeloid Leukemia." Blood 104, no. 11 (November 16, 2004): 1005. http://dx.doi.org/10.1182/blood.v104.11.1005.1005.
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Abstract Using a novel denaturing-high performance liquid chromatography (D-HPLC)-based screening method, we investigated the frequency and prognostic relevance of ABL mutations in 47 CML patients who never achieved a major cytogenetic response in 12 months of Imatinib therapy. Seven patients were enrolled in the CML/011/STI571 trial (early-CP patients treated with Imatinib 400 mg/d and peghilated-interferon) while the remaining 40 were enrolled in the CML/002/STI571 trial (late-CP patients resistant/refractory to α-interferon, treated with Imatinib 400 mg/d). For each patient, a longitudinal analysis was done on all the available samples collected from Imatinib start up to the twelfth month of therapy. A nested RT-PCR was set up and, for each sample, two fragments of 393 and 482 bp spanning the ABL kinase domain were analysed. Two out of 7 (29%) early-CP patients had mutations, resulting in both cases in novel aminoacid substitutions (F311I, E355D). Mutations were already detectable at 6 and 9 months, respectively, from Imatinib start. Nineteen out of 40 (48%) late-CP patients had mutations. Eleven patients showed mutations falling in close proximity (M244V) or within (G250E, Y253F, Y253H, E255K, E255V) the P-loop. Eight patients showed mutations outside the P-loop (F311L, F317L, M351, E355G, F359V, H396R and a silent mutation at codon 298). Mutations were already detectable after a median of 3 months (range, 1–6) from onset therapy. At the time of mutation detection, all patients but four had sustained hematologic response. Presence of a missense mutation was significantly associated with a greater likelihood of subsequent progression to accelerated phase/blast crisis (AP/BC)(P=0.0002) and shorter survival (P=0.001). Patients with mutations falling in close proximity or within the P-loop had a particularly poor outcome in terms of time to progression to AP/BC with respect to the remaining mutated patients (P=0.03). Our results indicate that: i) ABL kinase domain mutations may be found also in the setting of early-CP CML patients, even though they are not the predominant mechanisms of resistance; ii) as many as 50% of late-CP patients who fail to achieve cytogenetic control of the disease in the first 6 months of therapy already have evidence of a mutation by D-HPLC analysis; iii) within cytogenetic nonresponders, presence of ABL mutations may identify a subset of patients with particularly poor prognosis. Thus, irrespective of the hematologic response, regular monitoring for emerging mutations in the first months of Imatinib administration may play a crucial role in detecting patients for whom a revision of the therapeutic strategy should be considered.
Dissertations / Theses on the topic "Nineteen eleven, A.D"
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Alexander, Lou-Ella M. m. "Characterization of the Transcriptional Elongation Factor ELL3 in B cells and Its Role in B-cell Lymphoma Proliferation and Survival." Scholar Commons, 2018. http://scholarcommons.usf.edu/etd/7119.
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The studies presented in this dissertation establish the dynamics of Eleven nineteen Lysine-rich leukemia (ELL) family of elongation factors during B cell differentiation and provide a description of ELL3 function in B cells.
The transition from a mature naïve B cells into an activated B cell is dependent on a large increase in transcriptional output, which is followed by focused expression on secreted immunoglobulin upon terminal differentiation into plasma cell. While ELL family members have previously been implicated in alternative splicing at the immunoglobulin heavy chain locus in plasma cells, their presence and function prior to differentiation is currently not known. However, the use of elongation factors has been implied by the finding of mostly paused RNA polymerase II in the genome of naïve B cells.
In the first study, the expression of transcriptional elongation factor ELL3 is shown to be restricted to activated B cells and B cell lymphomas. All three family members were characterized in B cell lymphoma cell lines, genome wide expression, microarray analysis and primary B cell stimulus. The expression of ELL3 was induced upon activation of B cells concurrently with family member ELL. In addition, the abundant expression of ELL3 was restricted to GC derived B cell lymphoma cell lines. While the expression of ELL is maintained, the expression of ELL3 is diminished and ELL2 is up-regulated in terminally differentiated plasma cells.
The expression of master regulator of terminal plasma cell differentiation PRDM1 was inverse correlated with that of ELL3. To further establish PRDM1s role in regulating the ELL family member dynamics, global binding was assessed in plasma cell lines. Chromatin immunoprecipitation followed by quantitative PCR was utilized to identify direct association of PRDM1 at exclusively the ELL3 loci. Ectopic expression of PRDM1 in B cells down regulated the expression of ELL3. Furthermore, two consensus PRDM1 binding sites were defined at the ELL3 loci, which mediate significant repression of the promoter activity. Collectively, these experiments indicate that PRDM1 mediates the switch from ELL3 in B cells to ELL2 in plasma cells.
The data presented in the final chapter aimed at defining a function for ELL3 in the cells that express it most abundantly, which are B cell lymphoma cell lines. Transient depletion of ELL3 in a Burkitt’s lymphoma cell line resulted in a diminished proliferation rate due to a severe disruption of DNA replication and its regulators minichromosome maintenance proteins. Additionally, compromised cell division and mitotic regulators were observed along with increased DNA damage and cell death.
The data presented here demonstrate a key role for ELL3 in the proliferation and survival of B cell lymphomas and positions ELL3 as an attractive therapeutic target against B cell lymphoma’s with a germinal center origin.
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Abdelrahman, Hamdan [Verfasser]. "Spinal infections: analysis of 600 patients over eleven years / Hamdan Abdelrahman." Gießen : Universitätsbibliothek, 2018. http://d-nb.info/1155722272/34.
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Zimmermann, Heiner [Verfasser]. "Mutationen und aberrantes alternatives Spleißen von Ten-Eleven Translocation 2 (TET2) in myeloproliferativen Neoplasien / Heiner Zimmermann." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2013. http://d-nb.info/1038211409/34.
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Hassinger, Sebastian [Verfasser], and J. [Akademischer Betreuer] Kämper. "Das Num1-Protein stabilisiert den Spleißosom-assoziierten NineTeen-Komplex und erfüllt zusätzliche Funktionen in Ustilago maydis / Sebastian Hassinger. Betreuer: J. Kämper." Karlsruhe : KIT-Bibliothek, 2015. http://d-nb.info/1071893971/34.
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Mayakrishnan, Ravikumar [Verfasser], George [Gutachter] Coupland, and Martin [Gutachter] Hülskamp. "Modulation of transcription and alternative splicing by spliceosome-activating nineteen complex (NTC) in Arabidopsis thaliana / Ravikumar Mayakrishnan ; Gutachter: George Coupland, Martin Hülskamp." Köln : Universitäts- und Stadtbibliothek Köln, 2018. http://d-nb.info/1185632824/34.
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Zhang, Peng [Verfasser], M. Cristina [Akademischer Betreuer] Cardoso, and Beatrix [Akademischer Betreuer] Süß. "The regulation of Ten-eleven translocation proteins (methylcytosine modifiers) by methyl-CpG binding domain proteins (methylcytosine readers) / Peng Zhang ; M. Cristina Cardoso, Beatrix Süß." Darmstadt : Universitäts- und Landesbibliothek Darmstadt, 2016. http://d-nb.info/1115333046/34.
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Roady, Peter. "The National Security State That Wasn’t: Liberals, Conservatives, and the Fight to Define the Government’s Responsibilities in the 1930s and 1940s." Thesis, 2021. https://doi.org/10.7916/d8-fpjt-z463.
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“National security” is one of the most powerful terms in the American vocabulary. It commands wide deference and almost unlimited resources, and what counts as a national security matter determines many of the government’s priorities and responsibilities. It is surprising, therefore, that we know so little about how national security came to be defined in the way Americans have understood it for the last 75 years. The problem is one of perspective. Almost everything written about the history of national security approaches the topic with a present-day understanding of the term’s meaning in mind and uses the term instrumentally to explain something else—most often some aspect of American foreign policy. Most of these works assume that national security refers principally to physical security, that national security policymaking is a foreign policy matter, and that it has always been thus.
This dissertation historicizes the term national security. Rather than tracing the present-day conception of national security backwards in time, as has been the norm, it looks forward from the past. This shift in perspective reveals a history of national security that challenges the prevailing assumption that national security has always been a matter of physical security and foreign policy. When Franklin Roosevelt first put national security at the center of American political discourse in the 1930s, he equated it with individual economic security and considered domestic policy the primary domain for national security policymaking. Roosevelt also articulated a broad vision for the government’s national security responsibilities in the final years of his presidency that included economic, social, and physical security to be delivered through a mix of domestic and foreign policy. These findings raise a big question about American political development: why did the United States end up with separate “national security” and “welfare” states rather than the comprehensive national security state Roosevelt envisioned?
To answer that question, this dissertation focuses on the interactions between political language, public opinion, and the institutional development of the American state. Combining traditional historical research methods with text mining, network analysis, and data visualization, this dissertation charts the movement of policy areas into and out of the national security frame. Franklin Roosevelt succeeded in placing domestic policy into the national security frame in the mid-1930s, thereby justifying the expansion of the government’s domestic responsibilities. But this success catalyzed the nascent conservative movement, which launched a public persuasion campaign to limit the further expansion of the government’s domestic responsibilities by removing domestic policy from the national security frame. Roosevelt’s subsequent success putting foreign policy into the national security frame at the end of the 1930s created a powerful foreign policy establishment that claimed the mantle of national security exclusively for its work. The exclusion of domestic policy from the purview of national security policymaking was therefore largely an ironic result of Roosevelt’s two successes using the language of security to expand the government’s responsibilities.
Books on the topic "Nineteen eleven, A.D"
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Meara, Seán Ó. Gus d' aon turas. Baile Átha Cliath: Coiscéim, 2010.
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Ganzorig, Pu̇rėvsu̇rėngiĭn. "Khėlmėgdsėn u̇eiĭnkhėn", bui︠u︡u, 1990-d ony tȯgsȯgchid. Ulaanbaatar khot: Soëmbo Printing, 2020.
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Oda, Eiichirō. One piece: The eleven supernovas. San Francisco, Calif: VIZ Media, 2010.
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Duboscq, Geneviève. My longest night: An eleven-years-old French girl's memories of D-Day. Bath: Chivers, 1986.
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National Science Foundation (U.S.). Division of Science Resources Studies, ed. Real increase in 1988 national R&D funds estimated at lowest rate in eleven years. Washington, D.C: National Science Foundation, 1988.
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Board, Edmonton School, ed. Souvenir of the Edmonton schools: Issued at the opening of the high school, May ninth, nineteen hundred and eleven. [Edmonton?: s.n., 1997.
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Children's Books, Nineteen Eleven to Nineteen Eighty-Six. New York Public Library, 1988.
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Devers, Vernon. Ninety-Eight Years Eleven Months Nineteen Days. Two Sisters Writing & Publishing LLC, 2023.
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Liam Gillick: From Nineteen Ninety a to Nineteen Ninety D. JRP Ringier Kunstverlag AG, 2015.
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E, Ambrose Stephen. D-Day, June Sixth, Nineteen Forty-Four. Econo-Clad Books, 2002.
Find full textBook chapters on the topic "Nineteen eleven, A.D"
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"Extra Eleven-Nineteen Gene." In Encyclopedia of Cancer, 1361. Berlin, Heidelberg: Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-16483-5_2065.
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"Eleven-d im ensional su p erg rav ity." In The World in Eleven Dimensions, 13–72. CRC Press, 1999. http://dx.doi.org/10.1201/9781482268737-6.
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Syme, Ronald. "Dux." In The Roman revolution, 294–312. Oxford University PressNew York, NY, 2002. http://dx.doi.org/10.1093/oso/9780192803207.003.0021.
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Abstract HE adversary spent the winter in Greece, ready in his preparations of army and fleet, but not perhaps as resolute as he might appear. Antonius now had to stand beside Cleopatrathere could be no turning back. Patrae at the mouth of the Gulf of Corinth was his head-quarters. His forces, fed by corn-ships from Egypt, were strung out in a long line from Corcyra and Epirus to the south-western extremity of Peloponnesus. The land army under the command of Canidius comprised nineteen of his legions: the other eleven made up the garrison of Egypt, Cyrene, Syria and Macedonia.
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Mesthrie, Rajend. "Transcending the colonial?" In Colonial and Decolonial Linguistics, 46–61. Oxford University Press, 2020. http://dx.doi.org/10.1093/oso/9780198793205.003.0003.
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This chapter revisits the Linguistic Survey of India (Sir George Grierson, ed. 1903–28, eleven volumes in nineteen parts) in the context of its times, as well as from the hindsights of colonial linguistics. It reviews the motivation for the project, its intentions and practices, and adopts a critical perspective in also considering its interface with local rather than colonial concerns. In some ways the LSI is a product of its times, especially in terms of occasional stereotypes and prescriptive remarks. In most ways, however, it transcends Western “orientalist” preconceptions in terms of its field methods, data presentation, and discursive commentaries. Grierson could well be considered the first modern or even postmodern dialectologist. The chapter concludes by considering the application of the work to modern postcolonial contexts, such as post-plantation Indian communities in Trinidad and South Africa.
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Zingg, Alexandra, Laura Carter, Deevakar Rogith, Amy Franklin, Sudhakar Selvaraj, Jerrie Refuerzo, and Sahiti Myneni. "Digital Technology Needs in Maternal Mental Health: A Qualitative Inquiry." In Studies in Health Technology and Informatics. IOS Press, 2021. http://dx.doi.org/10.3233/shti210324.
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Digital technologies offer many opportunities to improve mental healthcare management for women seeking pre- and-postnatal care. They provide a discrete, practical medium that is well-suited for the sensitive nature of mental health. Women who are more prone to experiencing peripartum depression (PPD), such as those of low-socioeconomic background or in high-risk pregnancies, can benefit the most from such technologies. However, current digital interventions directed towards this population provide suboptimal support, and their responsiveness to end user needs is quite limited. Our objective is to understand the digital terrain of information needs for low-socioeconomic status women with high-risk pregnancies, specifically within the management of their mental health. This qualitative study consists of semi-structured focus groups and interviews with a sample of nineteen patients. A total of eleven core themes emerged from participant comments. Resulting themes highlighted the need for digital technologies that promote personalized care, a sense of community, and improved provider communication.
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Keller, E. F. "Coming of Age." In Literature, Science, Psychoanalysis, 1830-1970, 233–42. Oxford University PressOxford, 2003. http://dx.doi.org/10.1093/oso/9780199266678.003.0015.
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Abstract If Schroedinger’s ‘What is Life?’ was widely read in the 1950s by scientists interested in biology, J. D. Watson’s account of his and Francis Crick’s epochal achievement, The Double Helix, has, it seems, been read by virtually everyone. Since its original publication in 1968, it has been reissued eleven times (in English alone)-including a 1980 appearance in a Norton Critical Edition; it has sold many thousands of copies, and promises to remain a strong seller for some time to come. In 2002, 34 years after its first appearance, eleven English language editions were still in print.
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Hartley”, Trevor C. "Matrimonial (MARITAL) Property Rights in Conflict of Laws: a Reconsideration." In Reform and Development of Private International Law, 215–36. Oxford University PressOxford, 2002. http://dx.doi.org/10.1093/oso/9780199250080.003.0010.
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Abstract Matrimonial property rights may be definl:’d as propnty rights n;,sulting from marriage. Thi es ay i concerned with their international dimension, the choice-of:Jav,, problem that arise when a foreign element impinges on che situation. The leading cases almost all date from the nineteenth century. They arc based on social attitudes so at odds with chose of today chat the legalmlcs laid down may no longer be acceptable. We shall reconsider rhem in rhe lighr of modern values. Such reconsideration is also necessary in view of the enormous changes that have taken place in the substantive law. Purthermore, academic discussion ha hitherto been limited to disputes benveen the husband and the wift’ (or between one of them and the children claiming through the other). We shall consider whether the same rules should apply where creditors arc involved.
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"Eleven. The Fifties: The Incredible 3-D Wide-Screen Technicolor Stereophonic-Sound Ballyhoo Parade." In Cinema Houston, 195–202. University of Texas Press, 2007. http://dx.doi.org/10.7560/717008-014.
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Sukhachev, Nikolay L. "Notes from Underground in the Reception by Rumanian Readers." In “Notes from Underground” by F.M. Dostoevsky in the Culture of Europe and America, 371–77. A.M. Gorky Institute of World Literature of the Russian Academy of Sciences, 2021. http://dx.doi.org/10.22455/978-5-9208-0668-0-371-377.
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The article deals with the reception of F.M. Dostoevsky’s Notes from Underground in Romania. Particular attention is paid to translations of the story, the publication of Notes from Underground in the eleven-volume collected works of Dostoevsky in Romanian, as well as monographs by A. Covács, D. Cuşmerenco, I. Ianoşi.
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Hatfield, Mary. "Conclusion." In Growing Up in Nineteenth-Century Ireland, 218–26. Oxford University Press, 2019. http://dx.doi.org/10.1093/oso/9780198843429.003.0006.
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In 1860, nineteen-year-old James Armour, a Presbyterian from north Antrim, wrote a letter to his friend James Megaw with his opinion of the intellectual atmosphere at Queen’s University Belfast. He criticized the lack of religious fervour among students of divinity who he felt were attracted by the social prestige rather than the spiritual vocation of a ministerial career. He stated, ‘Many choose it [the church] from a desire of show and of having a respectable position in society; others for the sake of the L. S. D., others again for the sake of being called great but the greater number from the ambition of their parents.’...
Conference papers on the topic "Nineteen eleven, A.D"
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Wakano, Clay, Temesgen D. Fufa, Timothy J. Stasevich, Taara A. Avery, James G. McNally, and Kevin Gardner. "Abstract 4975: Dynamicin vivointeractions of the eleven-nineteen lysine-rich leukemia protein (ELL) in the mammalian nucleus." In Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1538-7445.am10-4975.
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Pavesi, G., G. Ardizzon, and G. Cavazzini. "Numerical and Experimental Investigations on a Centrifugal Pump With and Without a Vaned Diffuser." In ASME 2004 International Mechanical Engineering Congress and Exposition. ASMEDC, 2004. http://dx.doi.org/10.1115/imece2004-59544.
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Extensive research on centrifugal pumps was designed to investigate the impact of a diffuser on flow field instabilities and the noise generated by these instabilities. Activity was based upon a coupled use of measurements and 3D fully-viscous, unsteady computations. The test model was a seven-blade pump-turbine, used as a pump. Fitted with a vaneless diffuser, and two vaned diffusers with twenty-two adjustable, guide-diffuser vanes, and a return channel with eleven continuous vanes. Diffusers were equipped with eight pressure sensors in the adjustable guide-diffuser vanes, and nineteen pressure taps in the continuous vanes. To establish a link between the flow field structure and acoustic radiation, flow velocity was measured in the vaneless part of the diffuser. Piezoelectric transducers, placed flush with the wall, were used to measure pressure fluctuation inside the blade channels. Signal analysis was carried out in the frequency domain. Results showed the jet-wake flow pattern induced an unstable vortex, which influenced flow discharging from the adjacent passage, and destabilized jet-wake flow in the passage. This instability caused a periodic fluctuation at the discharge of the impeller. Fluctuations were found to be coherent from blade to blade, and to possess a rich harmonic content. Numerical analyses did not fully confirm these results.
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Packard, Nathan O., David Japikse, R. Daniel Maynes, and Steven E. Gorrell. "Numerical Characterization of the Inlet Flow for Eleven Radial Turbomachines." In ASME Turbo Expo 2010: Power for Land, Sea, and Air. ASMEDC, 2010. http://dx.doi.org/10.1115/gt2010-22366.
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Successful modeling of a turbomachine stage requires attention to many details, including a realistic understanding of the inlet flow field. Various levels of modeling, from 1-D to 3-D viscous, plus various levels of measurement, from a simple inlet shroud pressure tap to complex inlet surveys, are considered in design and development work. In this study, a careful review is made of measurement and calculation options for inlet modeling. Historical practice places a static pressure tap on the shroud just upstream of the impeller leading edge for experimental characterization of centrifugal turbomachines. Previously developed statistics based meanline models rely in part on this measured data. However, the location of the tap may be vulnerable to high gradients which would decrease the dependability of the developed models. Computational Fluid Dynamics (CFD) and Multi-Stream Tube (MST) analyses were performed to test the appropriateness of the historically placed static pressure tap location and to characterize the inlet flow of typical radial flow turbomachines. Eleven ConceptsNREC machines were chosen for investigation to provide a wide variety of inlet geometric and flow conditions. The results derived from the CFD and MST analyses suggest that the historically placed static pressure tap location is an inappropriate anchor point for model development. While the focus of this work is not intended to reveal why the inlet behaves as it does, it does reveal that for a wide variety of inlet configurations and impeller sizes, the presumed inlet tap location should no longer be used in experimental work. Steep gradients in the static pressure indicate that a relatively minor movement of the static pressure tap would significantly alter the experimental measurements and generate noise in statistical modeling. While large variations in the pressure field are apparent near the impeller leading edge for all machines considered, the study results show that the flow field is uniform and very predictable when well upstream of the impeller leading edge. A point approximately 3 blade heights upstream from the impeller leading edge appears to be a sound location to anchor 1-D meanline model development, as well as for future experimental investigation.
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Montag, Ethan, and Robert M. Boynton. "Rod influence in dichromatic surface color perception." In OSA Annual Meeting. Washington, D.C.: Optica Publishing Group, 1986. http://dx.doi.org/10.1364/oam.1986.my2.
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By means of monolexemic color naming of the 424 primary samples of the OSA Uniform Color Scales set, it is possible to establish the centroid location in that space of the eleven basic surface colors originally described by Berlin and Kay. For normals, this results in a meaningful 3-D configuration of the centroids of categorically distinct colors. An extension of this work with dichromat viewing fields subtending ~3° produced a configuration of centroids remarkably similar to that of normal controls, it was hypothesized that the dichromatic observers might be using information derived from rod excitation to supplement their remaining yellow-blue color discrimination. By the use of foveally fixated small fields or bleaching of the rods, this hypothesis was confirmed by a collapse of the 3-D array of centroids into a plane defined by yellow-blue and lightness variations.
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Rondon, Andres, and Sukru Guzey. "Evaluation of the Design Pressure and Failure Modes for the API 12F Shop Welded Flat Bottom Tanks for Oil Storage." In ASME 2016 Pressure Vessels and Piping Conference. American Society of Mechanical Engineers, 2016. http://dx.doi.org/10.1115/pvp2016-63714.
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This study aims to determine the failure modes of the eleven API 12F shop welded tanks plus two proposed new sizes through finite element and stress analysis of more than 350 different models. Four separate analysis where carried out throughout this investigation. An elastic stress analysis considering non-linear deformations was performed to determine the yielding pressure of the tanks and maximum design pressure. An elastic buckling mode analysis evaluated the potential buckling pressure as a failure mode of the tanks. The redistribution of stresses due to inelastic deformations and plastic collapse were evaluated through an elastic-plastic stress analysis. Finally, a wind load analysis was developed to study the stress levels and uplift deformation of the API 12F tank with greatest aspect ratio (H/D). The presented research provides meaningful engineering calculations to evaluate the current design and capacity of the API 12F flat bottom tanks guaranteeing a safe performance of the equipments.
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Chu, Tai-Ming. "Measurement of Stress Distribution in Various Ankle-Foot Orthoses." In ASME 1998 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 1998. http://dx.doi.org/10.1115/imece1998-0142.
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Abstract An Ankle-Foot Orthosis (AFO) is a rehabilitation device that supports and aligns the ankle and the foot to improve the functions of the ankle and foot (Wu, 1990). In today’s orthotic industry, polypropylene (PP, a Colyene™ Co-polymer plus Fleshtones and Colors) is used as a major orthotic plastic due to its high weight-strength ratio, high fatigue resistance, light weight, and excellent molding characteristics (1990). However, earlier failure and improper geometry design bring inconvenience in mobility and discomfort to many patients. A literature search shows several investigations have been conducted. A 3-D Finite Element Model (FEM) was developed by Chu, et al. (1995). The analysis includes the computation of the stress level and the determination of locations of stress concentration. Although the 3-D model provided useful information, limited dynamic results were obtained. Yamamoto, et al. (1993) made a comparative study on the mechanical characteristics of plastic AFOs. Eleven AFOs were tested with the motion of dorsiflexion/plantarflexion and inversion/eversion using a muscle-training machine. The objective of this experimental study is to understand the performance of five AFOs used during walking and the resulting deformation developed while under loads. It is intended that the design parameters of AFOs can be evaluated and modified.
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Boynton, Robert M. "Color naming and large color differences." In OSA Annual Meeting. Washington, D.C.: Optica Publishing Group, 1988. http://dx.doi.org/10.1364/oam.1988.mh2.
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Color perception is categorical. Although many words for describing colors have been invented and used, there are only eleven basic color terms that are unambiguously employed to describe more than a million discriminably different colors. The 424 samples of the OSA Uniform Color Scales set are intended to sample 3-D subjective color space uniformly. A given distance in this space is, therefore, intended to represent the same number of discriminable steps of color difference, whatever the starting point or direction of measurement. Each basic color term describes a region of subjective color space, with variable exactness rather than a point. Using systematic monolexemic color naming of the OSA samples, we have confirmed the special status of the basic colors and have determined the locations of their centroids and the extents of overlapping regions in standard conditions. The method, which has the dual advantages of requiring no training of subjects or use of comparison stimuli, has been used successfully to examine color constancy, color rendering, color blindness, cultural differences, and color perception in very young children.
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Barzegar, Sadegh, Mohammad Banae, Mohammad Ali Hamed, and Mohammad Qaheri Badr. "Physical Model Test of Water Intake Including Huge Pump Station and Drum Screen." In ASME 2008 27th International Conference on Offshore Mechanics and Arctic Engineering. ASMEDC, 2008. http://dx.doi.org/10.1115/omae2008-58007.
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A physical model, built at an undistorted scale of 1:15 tested the original design of the six drum screen and nineteen cooling water pump intake connected to header bay. The capacity of origin water intake including huge pump station and drum screen is 400,000 m3/hr. The study objectives were to evaluate as-designed screen bay and pump bay performance and to propose design modifications to optimize intake flow conditions with respect to head-losses, uniformity of the approach flow, evenness of pump throat velocity distribution, and free and subsurface vortex formation. The model was built and operated in accordance with froude-number similitude. It allowed accurate representation of complex flow patterns caused by the physical geometry of the approach bay and pump bays. The major factors that can affect the selection of a concept and design development for a water intake are: a) The occurrence of dead water zones, flow separation or reverse flow b) Vortex building and air entrainment in the pump compartments c) Submerged vortices building in the pump compartments d) Low velocity area e) Strong rotational flow f) Strong cross flow appear in front of pump units g) Pre rotation in the pump suction lines. Dye injection was used to examine the stratified flow behavior along water. The existing design of the pump bays was found to produce a uniform, symmetrical flow distribution in the approach flow, weak but persistent floor and side-wall-attached submerged vortices, avoiding cross flow and reverse flow in front of the pumps and negligible swirling motion in the pump suction. Modified design includes (i) profiling low velocity area (ii) adding flow deflectors along inner walls (iii) infill area of low velocity (iv) adding suspended baffle in front of drum screens (v) adding diffuser block in front of pumps (vi) provision of floating booms in front of pumps.
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Nava Castro, Rau´l, Wilbert E. Koh Cambranis, and Paul Baerenwald. "Vertical and Horizontal Migration of Gas Through the Marine Sediments of the Gulf of Mexico." In ASME 2011 30th International Conference on Ocean, Offshore and Arctic Engineering. ASMEDC, 2011. http://dx.doi.org/10.1115/omae2011-49073.
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Since petroleum exploitation began activity in the Gulf of Mexico, geophysical studies have been carried out to detect geological hazards and features, which can affect the design or installation of platforms or pipelines. In some of the studies it was noted that shallow gas accumulations increase their size and number through time. This paper presents a comparison of three geophysical studies which were carried out in 1978 [1], 1997 [2] and 2002 [3]. The comparison is complemented with results obtained from geotechnical studies performed in 2002 [4–7] to evaluate the influence of the gas on the properties of the foundation zone soils. In the 1997 geophysical study, there were more detected gas accumulations than in 1978. The existing gas accumulations (originally detected in 1978) also increased in size over the nineteen-year period. The same phenomenon was also identified in the geophysical study of 2002, when the results were compared with the study performed in 1997, it appeared that the shallow gas accumulations increased both their size and number considerably over a period of only five years. The only explanation found for this phenomenon was that gas migrates vertically from the reservoir along a major geological fault that crosses the entire area, forming a chimney. Once the gas reached the shallow strata, the gas spread laterally, saturating the area around the geological fault with gas. Sand Strata A, B, C and D (identified in the geotechnical investigation) were the primary gas-charged strata, that is, the gas migrates laterally within these strata until encountering soils that can not confine the pressure developed by the gas accumulation [8] or until the gas finds a route to escape upwards. As a consequence, a sudden or gradual emanation occurs, altering the initial characteristics of the foundation zone soils and/or possibly damaging marine structures, resulting in economic loss.
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Sayman, Ozan, Kelsey Jones, Ryan Hale, Eduardo Pereyra, and Cem Sarica. "Application of a Mechanistic PAGL Simulation Tool to San Juan Field Operations." In SPE Artificial Lift Conference and Exhibition - Americas. SPE, 2022. http://dx.doi.org/10.2118/209760-ms.
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Abstract A mechanistic plunger lift tool was developed to estimate cycle mechanics, liquid unloading, and avoid well integrity issues. The study focuses on the plunger-assisted gas lift (PAGL) wells operated with the two-piece plunger under low tubing wellhead pressure conditions. The fall and upstroke stages of two-piece plungers were analyzed for eleven wells from San Juan Basin. The fall velocity estimation for plunger parts was modeled for; shut-in, transitional and multiphase flow conditions. Fall and upstroke velocities were estimated using drag-based models that feature drag coefficient, wall factor, and two-phase correction. The field data up to three years from each well was compared with the PAGL Tool estimations. The downhole pressure gauge data was analyzed and compared with plunger liquid slug estimations for two wells. Plunger inspection data and shut-in, afterflow time effects on liquid loading and plunger cycle time were investigated. The PAGL Tool estimations for full-cycle times were in fair agreement with daily production and plunger lift data of 10 of the 11 wells. The field data and tools estimations for 2- 7/8 in tubing show that two-piece plungers can fall against 600 STB/d liquid and 2 mmscf/d gas production rates with little to no shut-in times, and lower operational boundary for surfacing can be as low as 300 mscf/d without requiring a pressure buildup. The lower gas production being sufficient for upstroke movement increases the operational range of PAGL. The main reason was the low wellhead pressure, which causes gas expansion and higher gas velocity along the well to increase drag force hence the upstroke capability of PAGL with lower gas production rates. The downhole pressure data was compared with multiphase flow simulation with plunger hydrostatic pressure removal. Higher afterflow time settings were shown to be increasing the arrival time data, which suggests a growth of the liquid accumulation at the bottom hole. Field data shows that plunger lift operation is not limited to wells with marginal production, and it can be used before liquid loading conditions. The hydrostatic pressure removal with plunger lift is shown with field data analysis and plunger lift tool estimations. The study presents that the continuous flow plunger lift operational range can be extended to lower production rates if lower wellhead pressure is achieved.
Reports on the topic "Nineteen eleven, A.D"
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Cram, Jana, Mary Levandowski, Kaci Fitzgibbon, and Andrew Ray. Water resources summary for the Snake River and Jackson Lake Reservoir in Grand Teton National Park and John D. Rockefeller, Jr. Memorial Parkway: Preliminary analysis of 2016 data. National Park Service, June 2021. http://dx.doi.org/10.36967/nrr-2285179.
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This report summarizes discharge and water quality monitoring data for the Snake River and Jackson Lake reservoir levels in Grand Teton National Park and John D. Rockefeller, Jr. Memorial Parkway for calendar year 2016. Annual and long-term discharge summaries and an evaluation of chemical conditions relative to state and federal water quality standards are presented. These results are considered provisional, and may be subject to change. River Discharge: Hydrographs for the Snake River at Flagg Ranch, WY, and Moose, WY, exhibit a general pattern of high early summer flows and lower baseflows occurring in late summer and fall. During much of 2016, flows at the Flagg Ranch monitoring location were similar to the 25th percentile of daily flows at that site. Peak flows at Flagg Ranch were similar to average peak flow from 1983 to 2015 but occurred eleven days earlier in the year compared to the long-term average. Peak flows and daily flows at the Moose monitoring station were below the long-term average. Peak flows occurred four days later than the long-term average. During summer months, the unnatural hydro-graph at the Moose monitoring location exhibited signs of flow regulation associated with the management of Jackson Lake. Water Quality Monitoring in the Snake River: Water quality in the Snake River exhibited seasonal variability over the sampling period. Specifically, total iron peaked during high flows. In contrast, chloride, sulfate, sodium, magnesium, and calcium levels were at their annual minimum during high flows. Jackson Lake Reservoir: Reservoir storage dynamics in Jackson Lake exhibit a pattern of spring filling associated with early snowmelt runoff reaching maximum storage in mid-summer (on or near July 1). During 2016, filling water levels and reservoir storage began to increase in Jackson Lake nearly two weeks earlier than the long-term average and coincident with increases in runoff-driven flows in the Snake River. Although peak storage in Jackson Lake was larger and occurred earlier than the long-term average, minimum storage levels were similar to the long-term average.
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Padhye, Suyash, Isaiah Mwamba, Kyubyung Kang, Samuel Labi, and Makarand Hastak. Safety, Mobility, and Cost Benefits of Closing One Direction of the Interstate in Rural Areas During Construction Work. Purdue University, 2021. http://dx.doi.org/10.5703/1288284317345.
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With specific regard to interstates in the rural area, Indiana Department of Transportation (INDOT) has expressed a need for research that sheds light on this Maintenance of Traffic (MOT) issue so the agency [INDOT and the contractor] can make informed decisions regarding the crossover sections versus the closure in one direction with detour roads. A number of studies have investigated the advantages and disadvantages of various MOT strategies; however, there is no specific study that can help INDOT traffic engineers and design engineers make decisions by comparing direct and indirect benefits of crossovers and detours (full lane closures). This research examined the advantages and disadvantages of entirely closing one direction of traffic over traditional work zone techniques (such as partial lane closure through median crossover) from the perspectives of the agency, road users, and the community. In the case of full closure, the study (a) examined the alternative MOT strategies and best practices through an extensive literature review and survey of agencies (b) investigated risk, benefit, and costs associated with selected detour routes (c) validated the identified critical factors through case studies in Indiana and at other states, and (d) implemented best practices in an expected project to evaluate the safety, mobility, and cost benefits of closing one direction. Through the literature review and four case studies, eleven KPIs for MOT strategy developments were identified. This study prioritized these KPIs through the survey questionnaire. The top five KPIs are (1) safety, (2) mobility, (3) budget constraint, (4) project duration, (5) complexity of project sites. Based on these KPIs and other findings presented in Section 4.3.3, this study has proposed a comparison tool for predetermined MOT strategies in the form of a flow-chart. This tool is followed by the scores or weights associated with each KPI. These scores are normalized—i.e., the most important KPI which is safety, has the maximum weightage 1 and rest of the KPIs are weighed relatively. INDOT has a set of editable documents which are references for making MOT decisions. This proposed flow-chart tool will “walk” the INDOT team through the use of these spreadsheets corresponding to the identified KPIs through this study. It will be at the discretion of the INDOT team as to which KPIs are relevant to the situation at hand. Therefore, the flow-chart tool is flexible to incorporate the dynamic nature of MOT strategy selection.
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Cytryn, Eddie, Mark R. Liles, and Omer Frenkel. Mining multidrug-resistant desert soil bacteria for biocontrol activity and biologically-active compounds. United States Department of Agriculture, January 2014. http://dx.doi.org/10.32747/2014.7598174.bard.
Full textAbstract:
Control of agro-associated pathogens is becoming increasingly difficult due to increased resistance and mounting restrictions on chemical pesticides and antibiotics. Likewise, in veterinary and human environments, there is increasing resistance of pathogens to currently available antibiotics requiring discovery of novel antibiotic compounds. These drawbacks necessitate discovery and application of microorganisms that can be used as biocontrol agents (BCAs) and the isolation of novel biologically-active compounds. This highly-synergistic one year project implemented an innovative pipeline aimed at detecting BCAs and associated biologically-active compounds, which included: (A) isolation of multidrug-resistant desert soil bacteria and root-associated bacteria from medicinal plants; (B) invitro screening of bacterial isolates against known plant, animal and human pathogens; (C) nextgeneration sequencing of isolates that displayed antagonistic activity against at least one of the model pathogens and (D) in-planta screening of promising BCAs in a model bean-Sclerotiumrolfsii system. The BCA genome data were examined for presence of: i) secondary metabolite encoding genes potentially linked to the anti-pathogenic activity of the isolates; and ii) rhizosphere competence-associated genes, associated with the capacity of microorganisms to successfully inhabit plant roots, and a prerequisite for the success of a soil amended BCA. Altogether, 56 phylogenetically-diverse isolates with bioactivity against bacterial, oomycete and fungal plant pathogens were identified. These strains were sent to Auburn University where bioassays against a panel of animal and human pathogens (including multi-drug resistant pathogenic strains such as A. baumannii 3806) were conducted. Nineteen isolates that showed substantial antagonistic activity against at least one of the screened pathogens were sequenced, assembled and subjected to bioinformatics analyses aimed at identifying secondary metabolite-encoding and rhizosphere competence-associated genes. The genome size of the bacteria ranged from 3.77 to 9.85 Mbp. All of the genomes were characterized by a plethora of secondary metabolite encoding genes including non-ribosomal peptide synthase, polyketidesynthases, lantipeptides, bacteriocins, terpenes and siderophores. While some of these genes were highly similar to documented genes, many were unique and therefore may encode for novel antagonistic compounds. Comparative genomic analysis of root-associated isolates with similar strains not isolated from root environments revealed genes encoding for several rhizospherecompetence- associated traits including urea utilization, chitin degradation, plant cell polymerdegradation, biofilm formation, mechanisms for iron, phosphorus and sulfur acquisition and antibiotic resistance. Our labs are currently writing a continuation of this feasibility study that proposes a unique pipeline for the detection of BCAs and biopesticides that can be used against phytopathogens. It will combine i) metabolomic screening of strains from our collection that contain unique secondary metabolite-encoding genes, in order to isolate novel antimicrobial compounds; ii) model plant-based experiments to assess the antagonistic capacities of selected BCAs toward selected phytopathogens; and iii) an innovative next-generation-sequencing based method to monitor the relative abundance and distribution of selected BCAs in field experiments in order to assess their persistence in natural agro-environments. We believe that this integrated approach will enable development of novel strains and compounds that can be used in large-scale operations.